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Conserved domains on  [gi|767973123|ref|XP_011536184|]
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leucine-rich repeat serine/threonine-protein kinase 2 isoform X10 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1000960)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK15370 super family cl33128
type III secretion system effector E3 ubiquitin transferase SlrP;
1015-1257 2.72e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


The actual alignment was detected with superfamily member PRK15370:

Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 80.90  E-value: 2.72e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1015 KLELHQNALTSFPQQLCEtlkSLTHLDLHSNKFTSFPSYLlkMSCIANLDVSRNDIG--PSVVLDptvkcpTLKQFNLSY 1092
Cdd:PRK15370  182 ELRLKILGLTTIPACIPE---QITTLILDNNELKSLPENL--QGNIKTLYANSNQLTsiPATLPD------TIQEMELSI 250
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1093 NQLSFVPENLTDVvekLEQLILEGNKISgiCSPLRL-KELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMpfL 1171
Cdd:PRK15370  251 NRITELPERLPSA---LQSLDLFHNKIS--CLPENLpEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPET--L 323
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1172 PPSMTILKLSQNKFSCIPEAIlnLPHLRSLDMSSNDIQYLPgpahwKSL--NLRELLFSHNqiSILDLSEKayLWSRVEK 1249
Cdd:PRK15370  324 PPGLKTLEAGENALTSLPASL--PPELQVLDVSKNQITVLP-----ETLppTITTLDVSRN--ALTNLPEN--LPAALQI 392

                  ....*...
gi 767973123 1250 LHLSHNKL 1257
Cdd:PRK15370  393 MQASRNNL 400
 
Name Accession Description Interval E-value
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
1015-1257 2.72e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 80.90  E-value: 2.72e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1015 KLELHQNALTSFPQQLCEtlkSLTHLDLHSNKFTSFPSYLlkMSCIANLDVSRNDIG--PSVVLDptvkcpTLKQFNLSY 1092
Cdd:PRK15370  182 ELRLKILGLTTIPACIPE---QITTLILDNNELKSLPENL--QGNIKTLYANSNQLTsiPATLPD------TIQEMELSI 250
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1093 NQLSFVPENLTDVvekLEQLILEGNKISgiCSPLRL-KELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMpfL 1171
Cdd:PRK15370  251 NRITELPERLPSA---LQSLDLFHNKIS--CLPENLpEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPET--L 323
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1172 PPSMTILKLSQNKFSCIPEAIlnLPHLRSLDMSSNDIQYLPgpahwKSL--NLRELLFSHNqiSILDLSEKayLWSRVEK 1249
Cdd:PRK15370  324 PPGLKTLEAGENALTSLPASL--PPELQVLDVSKNQITVLP-----ETLppTITTLDVSRN--ALTNLPEN--LPAALQI 392

                  ....*...
gi 767973123 1250 LHLSHNKL 1257
Cdd:PRK15370  393 MQASRNNL 400
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1012-1262 2.23e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 227223 [Multi-domain]  Cd Length: 394  Bit Score: 67.30  E-value: 2.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1012 HLEKLELHQNALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYL----LKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQ 1087
Cdd:COG4886    41 NLESVAVNRLALNLSSNTLLLLPSSLSRLLSLDLLSPSGISSLdgseNLLNLLPLPSLDLNLNRLRSNISELLELTNLTS 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1088 FNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLR-LKELKILNLSKNHISSLSENFLEacpkvesfsarmnfla 1166
Cdd:COG4886   121 LDLDNNNITDIPPLIGLLKSNLKELDLSDNKIESLPSPLRnLPNLKNLDLSFNDLSDLPKLLSN---------------- 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1167 ampflPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPgPAHWKSLNLRELLFSHNQisILDLSEKAYLWSR 1246
Cdd:COG4886   185 -----LSNLNNLDLSGNKISDLPPEIELLSALEELDLSNNSIIELL-SSLSNLKNLSGLELSNNK--LEDLPESIGNLSN 256
                         250
                  ....*....|....*.
gi 767973123 1247 VEKLHLSHNKLKEVSS 1262
Cdd:COG4886   257 LETLDLSNNQISSISS 272
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
984-1169 2.16e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.11  E-value: 2.16e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123  984 ITSLDLSANELRDIDALSQkCCisvhleHLEKLELHQNALTSFPQqlCETLKSLTHLDLHSNKFTSFPSyLLKMSCIANL 1063
Cdd:cd21340     4 ITHLYLNDKNITKIDNLSL-CK------NLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKL 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1064 DVSRNDIgpSVV--LDptvKCPTLKQFNLSYNQL------SFVPENLTDVVEKLEQLILEGNKISGIcSPLR-LKELKIL 1134
Cdd:cd21340    74 YLGGNRI--SVVegLE---NLTNLEELHIENQRLppgeklTFDPRSLAALSNSLRVLNISGNNIDSL-EPLApLRNLEQL 147
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 767973123 1135 NLSKNHISSLSE--NFLEACPKVESFSARMNFLAAMP 1169
Cdd:cd21340   148 DASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
985-1047 1.11e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 1.11e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767973123   985 TSLDLSANELRDIDALSqkcciSVHLEHLEKLELHQNALTSFPQQLCETLKSLTHLDLHSNKF 1047
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGA-----FKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
1015-1257 2.72e-15

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 80.90  E-value: 2.72e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1015 KLELHQNALTSFPQQLCEtlkSLTHLDLHSNKFTSFPSYLlkMSCIANLDVSRNDIG--PSVVLDptvkcpTLKQFNLSY 1092
Cdd:PRK15370  182 ELRLKILGLTTIPACIPE---QITTLILDNNELKSLPENL--QGNIKTLYANSNQLTsiPATLPD------TIQEMELSI 250
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1093 NQLSFVPENLTDVvekLEQLILEGNKISgiCSPLRL-KELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMpfL 1171
Cdd:PRK15370  251 NRITELPERLPSA---LQSLDLFHNKIS--CLPENLpEELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPET--L 323
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1172 PPSMTILKLSQNKFSCIPEAIlnLPHLRSLDMSSNDIQYLPgpahwKSL--NLRELLFSHNqiSILDLSEKayLWSRVEK 1249
Cdd:PRK15370  324 PPGLKTLEAGENALTSLPASL--PPELQVLDVSKNQITVLP-----ETLppTITTLDVSRN--ALTNLPEN--LPAALQI 392

                  ....*...
gi 767973123 1250 LHLSHNKL 1257
Cdd:PRK15370  393 MQASRNNL 400
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
982-1200 1.25e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 75.50  E-value: 1.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123  982 EYITSLDLSANELR--------DIDALS----QKCCISVHL-EHLEKLELHQNALTSFPQQLCETLKSlthLDLHSNKFT 1048
Cdd:PRK15370  199 EQITTLILDNNELKslpenlqgNIKTLYansnQLTSIPATLpDTIQEMELSINRITELPERLPSALQS---LDLFHNKIS 275
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1049 SFPSYLLKMscIANLDVSRNDIGPSVVLDPTvkcpTLKQFNLSYNQLSFVPENLTdvvEKLEQLILEGNKISgiCSPLRL 1128
Cdd:PRK15370  276 CLPENLPEE--LRYLSVYDNSIRTLPAHLPS----GITHLNVQSNSLTALPETLP---PGLKTLEAGENALT--SLPASL 344
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767973123 1129 -KELKILNLSKNHISSLSENFleaCPKVESFSARMNFLAAMP-FLPPSMTILKLSQNKFSCIPEAilnLPHLRS 1200
Cdd:PRK15370  345 pPELQVLDVSKNQITVLPETL---PPTITTLDVSRNALTNLPeNLPAALQIMQASRNNLVRLPES---LPHFRG 412
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1012-1262 2.23e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 227223 [Multi-domain]  Cd Length: 394  Bit Score: 67.30  E-value: 2.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1012 HLEKLELHQNALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYL----LKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQ 1087
Cdd:COG4886    41 NLESVAVNRLALNLSSNTLLLLPSSLSRLLSLDLLSPSGISSLdgseNLLNLLPLPSLDLNLNRLRSNISELLELTNLTS 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1088 FNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLR-LKELKILNLSKNHISSLSENFLEacpkvesfsarmnfla 1166
Cdd:COG4886   121 LDLDNNNITDIPPLIGLLKSNLKELDLSDNKIESLPSPLRnLPNLKNLDLSFNDLSDLPKLLSN---------------- 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1167 ampflPPSMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPgPAHWKSLNLRELLFSHNQisILDLSEKAYLWSR 1246
Cdd:COG4886   185 -----LSNLNNLDLSGNKISDLPPEIELLSALEELDLSNNSIIELL-SSLSNLKNLSGLELSNNK--LEDLPESIGNLSN 256
                         250
                  ....*....|....*.
gi 767973123 1247 VEKLHLSHNKLKEVSS 1262
Cdd:COG4886   257 LETLDLSNNQISSISS 272
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
980-1244 1.67e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 227223 [Multi-domain]  Cd Length: 394  Bit Score: 64.60  E-value: 1.67e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123  980 EREYITSLDL---SANELRDIDALSqkccisvhLEHLEKLELHQNALTSFPQQLcETLKSLTHLDLHSNKFTSFPSYLLK 1056
Cdd:COG4886   114 ELTNLTSLDLdnnNITDIPPLIGLL--------KSNLKELDLSDNKIESLPSPL-RNLPNLKNLDLSFNDLSDLPKLLSN 184
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1057 MSCIANLDVSRNDIgpSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDvVEKLEQLILEGNKISGICSPL-RLKELKILN 1135
Cdd:COG4886   185 LSNLNNLDLSGNKI--SDLPPEIELLSALEELDLSNNSIIELLSSLSN-LKNLSGLELSNNKLEDLPESIgNLSNLETLD 261
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1136 LSKNHISSLSenfleacpkveSFSARMNFlaampflppsmTILKLSQNKFSCIPEAILNLPHLRSLDmSSNDIQYLPGPA 1215
Cdd:COG4886   262 LSNNQISSIS-----------SLGSLTNL-----------RELDLSGNSLSNALPLIALLLLLLELL-LNLLLTLKALEL 318
                         250       260       270
                  ....*....|....*....|....*....|...
gi 767973123 1216 H----WKSLNLRELLFSHNQISILDLSEKAYLW 1244
Cdd:COG4886   319 KlnsiLLNNNILSNGETSSPEALSILESLNNLW 351
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
984-1169 2.16e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.11  E-value: 2.16e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123  984 ITSLDLSANELRDIDALSQkCCisvhleHLEKLELHQNALTSFPQqlCETLKSLTHLDLHSNKFTSFPSyLLKMSCIANL 1063
Cdd:cd21340     4 ITHLYLNDKNITKIDNLSL-CK------NLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKL 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1064 DVSRNDIgpSVV--LDptvKCPTLKQFNLSYNQL------SFVPENLTDVVEKLEQLILEGNKISGIcSPLR-LKELKIL 1134
Cdd:cd21340    74 YLGGNRI--SVVegLE---NLTNLEELHIENQRLppgeklTFDPRSLAALSNSLRVLNISGNNIDSL-EPLApLRNLEQL 147
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 767973123 1135 NLSKNHISSLSE--NFLEACPKVESFSARMNFLAAMP 1169
Cdd:cd21340   148 DASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
984-1206 6.01e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.17  E-value: 6.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123  984 ITSLDLSANELRdidalSQKCCISVHLEHLEKLELHQNALT-SFPQQLCETLKSLTHLDLHSNKFT-SFPSYLLkmSCIA 1061
Cdd:PLN00113   71 VVSIDLSGKNIS-----GKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSI--PNLE 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1062 NLDVSRNDIGPSVVLDPTVkCPTLKQFNLSYNQLS-FVPENLTDVVeKLEQLILEGNKISG-ICSPL-RLKELKILNLSK 1138
Cdd:PLN00113  144 TLDLSNNMLSGEIPNDIGS-FSSLKVLDLGGNVLVgKIPNSLTNLT-SLEFLTLASNQLVGqIPRELgQMKSLKWIYLGY 221
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767973123 1139 NHISSLSENFLEACPKVESFSARMNFLAAMpfLPPSMTILK------LSQNKFS-CIPEAILNLPHLRSLDMSSN 1206
Cdd:PLN00113  222 NNLSGEIPYEIGGLTSLNHLDLVYNNLTGP--IPSSLGNLKnlqylfLYQNKLSgPIPPSIFSLQKLISLDLSDN 294
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
1010-1257 7.33e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 53.70  E-value: 7.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1010 LEHLEKLELHQNALTSFPQQLCETLKSLTHLDLHSNKFT-------------------------SFPSYLLKMSCIANLD 1064
Cdd:PLN00113  283 LQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgkipvaltslprlqvlqlwsnkfsgEIPKNLGKHNNLTVLD 362
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1065 VSRNDIGPSVvldPTVKCPTLKQFNL---SYNQLSFVPENLTDvVEKLEQLILEGNKISGICSP--LRLKELKILNLSKN 1139
Cdd:PLN00113  363 LSTNNLTGEI---PEGLCSSGNLFKLilfSNSLEGEIPKSLGA-CRSLRRVRLQDNSFSGELPSefTKLPLVYFLDISNN 438
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1140 HISSLSENFLEACPKVESFS-ARMNFLAAMP--FLPPSMTILKLSQNKFS-CIPEAILNLPHLRSLDMSSNDIQYLPgPA 1215
Cdd:PLN00113  439 NLQGRINSRKWDMPSLQMLSlARNKFFGGLPdsFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGEI-PD 517
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 767973123 1216 HWKSL-NLRELLFSHNQIS---ILDLSEKAYLwsrvEKLHLSHNKL 1257
Cdd:PLN00113  518 ELSSCkKLVSLDLSHNQLSgqiPASFSEMPVL----SQLDLSQNQL 559
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
1034-1255 1.26e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.55  E-value: 1.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1034 LKSLTHLDLHSNKFTSfpsyllkmscIANLDVsrndigpsvvldptvkCPTLKQFNLSYNQLSFVP--ENLTdvveKLEQ 1111
Cdd:cd21340     1 LKRITHLYLNDKNITK----------IDNLSL----------------CKNLKVLYLYDNKITKIEnlEFLT----NLTH 50
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1112 LILEGNKISGICSPLRLKELKILNLSKNHISSLsENfLEACPKVESFS-ARMNflaampfLPPSMTILklsqnkFSciPE 1190
Cdd:cd21340    51 LYLQNNQIEKIENLENLVNLKKLYLGGNRISVV-EG-LENLTNLEELHiENQR-------LPPGEKLT------FD--PR 113
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767973123 1191 AILNL-PHLRSLDMSSNDIQYLPGPAHWKslNLRELLFSHNQIS-ILDLSEKAYLWSRVEKLHLSHN 1255
Cdd:cd21340   114 SLAALsNSLRVLNISGNNIDSLEPLAPLR--NLEQLDASNNQISdLEELLDLLSSWPSLRELDLTGN 178
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
986-1208 5.31e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.05  E-value: 5.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123  986 SLDLSANELRDIDALSqkccISVHLEHLEKLELHQNALT-SFPQQLCETL---KSLTHLDLHSNKFTSFP-------SYL 1054
Cdd:cd00116     2 QLSLKGELLKTERATE----LLPKLLCLQVLRLEGNTLGeEAAKALASALrpqPSLKELCLSLNETGRIPrglqsllQGL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1055 LKMSCIANLDVSRNDIGP--SVVLDPTVKCPTLKQFNLSYNQLS-----FVPENLTDVVEKLEQLILEGNKISGICSPLR 1127
Cdd:cd00116    78 TKGCGLQELDLSDNALGPdgCGVLESLLRSSSLQELKLNNNGLGdrglrLLAKGLKDLPPALEKLVLGRNRLEGASCEAL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1128 LKE------LKILNLSKNHIS-----SLSENFLEACpKVESFSARMN--------FLAAMPFLPPSMTILKLSQNKFS-- 1186
Cdd:cd00116   158 AKAlranrdLKELNLANNGIGdagirALAEGLKANC-NLEVLDLNNNgltdegasALAETLASLKSLEVLNLGDNNLTda 236
                         250       260
                  ....*....|....*....|....*.
gi 767973123 1187 CIPEAILNLPH----LRSLDMSSNDI 1208
Cdd:cd00116   237 GAAALASALLSpnisLLTLSLSCNDI 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
970-1115 1.96e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 227223 [Multi-domain]  Cd Length: 394  Bit Score: 48.43  E-value: 1.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123  970 HSDSISSLASEREYITSLDLSANELRDIDALSQKCCisvhleHLEKLELHQNALTSFPQQLcETLKSLTHLDLHSNKFTS 1049
Cdd:COG4886   174 DLSDLPKLLSNLSNLNNLDLSGNKISDLPPEIELLS------ALEELDLSNNSIIELLSSL-SNLKNLSGLELSNNKLED 246
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767973123 1050 FPSYLLKMSCIANLDVSRNDIgpsVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILE 1115
Cdd:COG4886   247 LPESIGNLSNLETLDLSNNQI---SSISSLGSLTNLRELDLSGNSLSNALPLIALLLLLLELLLNL 309
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
972-1208 2.94e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 48.62  E-value: 2.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123  972 DSISSLASEREYITSLDLSANELRDIDALS----QKCCISVHLEHLE-------KLELHQNALTSFPQqLCETLKSLTHL 1040
Cdd:PRK15387  232 NNLTSLPALPPELRTLEVSGNQLTSLPVLPpgllELSIFSNPLTHLPalpsglcKLWIFGNQLTSLPV-LPPGLQELSVS 310
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1041 DLHSNKFTSFPSYLLKMSCIANLDVSRndigpsvvldPTVkcPT-LKQFNLSYNQLSFVPEnltdVVEKLEQLILEGNKI 1119
Cdd:PRK15387  311 DNQLASLPALPSELCKLWAYNNQLTSL----------PTL--PSgLQELSVSDNQLASLPT----LPSELYKLWAYNNRL 374
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1120 SGICS-PLRLKELKIlnlSKNHISSLSenfleACP-KVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEAILNLPH 1197
Cdd:PRK15387  375 TSLPAlPSGLKELIV---SGNRLTSLP-----VLPsELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIHLSS 446
                         250
                  ....*....|.
gi 767973123 1198 LRSLDMSSNDI 1208
Cdd:PRK15387  447 ETTVNLEGNPL 457
LRR_8 pfam13855
Leucine rich repeat;
985-1047 1.11e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 1.11e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767973123   985 TSLDLSANELRDIDALSqkcciSVHLEHLEKLELHQNALTSFPQQLCETLKSLTHLDLHSNKF 1047
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGA-----FKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
1108-1261 2.20e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.01  E-value: 2.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1108 KLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLsENfLEACPKVESFSARMNFLAAMPFLP--PSMTILKLSQNKF 1185
Cdd:cd21340     3 RITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKI-EN-LEFLTNLTHLYLQNNQIEKIENLEnlVNLKKLYLGGNRI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1186 SCIpEAILNLPHLRSLDMSSNDI----QYLPGPAHWKSL--NLRELLFSHNQISilDLSEKAYLwSRVEKLHLSHNKLKE 1259
Cdd:cd21340    81 SVV-EGLENLTNLEELHIENQRLppgeKLTFDPRSLAALsnSLRVLNISGNNID--SLEPLAPL-RNLEQLDASNNQISD 156

                  ..
gi 767973123 1260 VS 1261
Cdd:cd21340   157 LE 158
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
1010-1260 3.11e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 3.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1010 LEHLEKLELHQNALT-SFPQQLCEtLKSLTHLDLHSNKFT-SFPSYLLKMSCIANLDVSRNDIG---PSVVLdptvKCPT 1084
Cdd:PLN00113  235 LTSLNHLDLVYNNLTgPIPSSLGN-LKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgeiPELVI----QLQN 309
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1085 LKQFNLSYNQLS-FVPENLTDVvEKLEQLILEGNKISG-ICSPL-RLKELKILNLSKNHISS-LSENFLEA--CPKVESF 1158
Cdd:PLN00113  310 LEILHLFSNNFTgKIPVALTSL-PRLQVLQLWSNKFSGeIPKNLgKHNNLTVLDLSTNNLTGeIPEGLCSSgnLFKLILF 388
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1159 SarmNFLAAMpfLPPSMTI------LKLSQNKFSC-IPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQ 1231
Cdd:PLN00113  389 S---NSLEGE--IPKSLGAcrslrrVRLQDNSFSGeLPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNK 463
                         250       260       270
                  ....*....|....*....|....*....|.
gi 767973123 1232 IS--ILDLSEKaylwSRVEKLHLSHNKLKEV 1260
Cdd:PLN00113  464 FFggLPDSFGS----KRLENLDLSRNQFSGA 490
LRR_8 pfam13855
Leucine rich repeat;
1130-1208 3.37e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 3.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123  1130 ELKILNLSKNHISSLSenfleacpkVESFSArmnflaampflPPSMTILKLSQNKFSCI-PEAILNLPHLRSLDMSSNDI 1208
Cdd:pfam13855    2 NLRSLDLSNNRLTSLD---------DGAFKG-----------LSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
984-1206 3.50e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 3.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123  984 ITSLDLSANELRDidALSQKCCISvhlEHLEKLELHQNALTS-FPQQLcETLKSLTHLDLHSNKFT-SFPSYLLKMSCIA 1061
Cdd:PLN00113  358 LTVLDLSTNNLTG--EIPEGLCSS---GNLFKLILFSNSLEGeIPKSL-GACRSLRRVRLQDNSFSgELPSEFTKLPLVY 431
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1062 NLDVSRNDIG----------PSVV------------LDPTVKCPTLKQFNLSYNQLS-FVPENLTDVVEkLEQLILEGNK 1118
Cdd:PLN00113  432 FLDISNNNLQgrinsrkwdmPSLQmlslarnkffggLPDSFGSKRLENLDLSRNQFSgAVPRKLGSLSE-LMQLKLSENK 510
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1119 ISGICsPLRL---KELKILNLSKNHISSlsenfleACPkvESFSarmnflaAMPFLppsmTILKLSQNKFSC-IPEAILN 1194
Cdd:PLN00113  511 LSGEI-PDELsscKKLVSLDLSHNQLSG-------QIP--ASFS-------EMPVL----SQLDLSQNQLSGeIPKNLGN 569
                         250
                  ....*....|..
gi 767973123 1195 LPHLRSLDMSSN 1206
Cdd:PLN00113  570 VESLVQVNISHN 581
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
976-1064 3.70e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.24  E-value: 3.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123  976 SLASEREYITSLDLSANELRDIDALSqkccisvHLEHLEKLELHQNALTSFpQQLCETLKS---LTHLDLHSNKFTSFPS 1052
Cdd:cd21340   114 SLAALSNSLRVLNISGNNIDSLEPLA-------PLRNLEQLDASNNQISDL-EELLDLLSSwpsLRELDLTGNPVCKKPK 185
                          90
                  ....*....|....*.
gi 767973123 1053 Y----LLKMSCIANLD 1064
Cdd:cd21340   186 YrdkiILASKSLEVLD 201
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
1084-1267 4.19e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 227223 [Multi-domain]  Cd Length: 394  Bit Score: 44.19  E-value: 4.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1084 TLKQFNLSYNQLSFVPENLTDVVekLEQLILEGNKISGICSPLRLKELKILNLSKNHISSLSENfleacpkvESFSARMN 1163
Cdd:COG4886    19 EVLSSNTYHTTPQSINLNFPDSN--LESVAVNRLALNLSSNTLLLLPSSLSRLLSLDLLSPSGI--------SSLDGSEN 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123 1164 FLAAMPflppsMTILKLSQNKFSCIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDlSEKAYL 1243
Cdd:COG4886    89 LLNLLP-----LPSLDLNLNRLRSNISELLELTNLTSLDLDNNNITDIPPLIGLLKSNLKELDLSDNKIESLP-SPLRNL 162
                         170       180
                  ....*....|....*....|....
gi 767973123 1244 wSRVEKLHLSHNKLKEVSSTAIKK 1267
Cdd:COG4886   163 -PNLKNLDLSFNDLSDLPKLLSNL 185
LRR_8 pfam13855
Leucine rich repeat;
1012-1070 2.25e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 2.25e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767973123  1012 HLEKLELHQNALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLL-KMSCIANLDVSRNDI 1070
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFsGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
1173-1232 4.10e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 4.10e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767973123  1173 PSMTILKLSQNKFSCI-PEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQI 1232
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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