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Conserved domains on  [gi|767975995|ref|XP_011537316|]
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electroneutral sodium bicarbonate exchanger 1 isoform X5 [Homo sapiens]

Protein Classification

sodium bicarbonate transporter family protein( domain architecture ID 10469757)

sodium bicarbonate transporter family protein similar to Homo sapiens sodium bicarbonate transporter-like protein 11 that plays an important role in sodium-mediated fluid transport in different organs

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
HCO3_cotransp pfam00955
HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange ...
1-487 0e+00

HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.


:

Pssm-ID: 425961  Cd Length: 497  Bit Score: 775.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995    1 MSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQALTILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLW 80
Cdd:pfam00955  41 LSPAITFGGLLGDATDGYIGVSESILSTAIGGIIFALFSGQPLTILGSTGPLLVFEKILYSFCKDNGLDYLSFRVWIGLW 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995   81 TAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQldhlslYYCRCTLPENPNNHTL 160
Cdd:pfam00955 121 LAFFLLLLVAFDASFLVRYITRFTEEIFALLISLIFIYEAFKKLFKIFKKYPLYYNYN------CTCVPPDNNNTTNSTL 194
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995  161 QYWKDHNivtaEVHWAN-LTVSEC-QEMHGEFMGSACGhhgpYTPDVLFWSCILFFTTFILSSTLKTFKTSRYFPTRVRS 238
Cdd:pfam00955 195 SLSTENS----EINWSSlLTNSECtGSYGGTLVGSGCG----YVPDTALLSLILFLGTFWLAYFLKNFKNSPFFPTKVRR 266
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995  239 MVSDFAVFLTIFTMVIIDFLIGVPSPKLQVPSVFKPTRDDRGWIINPIGPNPWWTVIAAIIPALLCTILIFMDQQITAVI 318
Cdd:pfam00955 267 LISDFAVPIAILIMVLVDYFLGVYTPKLQVPSGFKPTDPDRGWLINPFGKNPWWLIFAAALPALLVTILIFMDQQITAVI 346
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995  319 INRKEHKLKKGCGYHLDLLMVAIMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFV 398
Cdd:pfam00955 347 VNRKENKLKKGSGYHLDLLVVAILNGICSLFGLPWMVAATVRSITHVNSLKVESETVAPGEKPKILGVREQRVTGLLVFI 426
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995  399 LMGCSVFMTAILKFIPMPVLYGVFLYMGVSSLQGIqsqfpflsrgngvtylseQFFDRLKLFGMPAKHQPDFIYLRHVPL 478
Cdd:pfam00955 427 LIGLSVFMTPVLKLIPMPVLYGVFLYMGVTSLNGI------------------QFFDRILLLFMPQKHQPDTHYLRHVPL 488

                  ....*....
gi 767975995  479 RKVHLFTLI 487
Cdd:pfam00955 489 RKVHLFTLI 497
 
Name Accession Description Interval E-value
HCO3_cotransp pfam00955
HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange ...
1-487 0e+00

HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.


Pssm-ID: 425961  Cd Length: 497  Bit Score: 775.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995    1 MSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQALTILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLW 80
Cdd:pfam00955  41 LSPAITFGGLLGDATDGYIGVSESILSTAIGGIIFALFSGQPLTILGSTGPLLVFEKILYSFCKDNGLDYLSFRVWIGLW 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995   81 TAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQldhlslYYCRCTLPENPNNHTL 160
Cdd:pfam00955 121 LAFFLLLLVAFDASFLVRYITRFTEEIFALLISLIFIYEAFKKLFKIFKKYPLYYNYN------CTCVPPDNNNTTNSTL 194
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995  161 QYWKDHNivtaEVHWAN-LTVSEC-QEMHGEFMGSACGhhgpYTPDVLFWSCILFFTTFILSSTLKTFKTSRYFPTRVRS 238
Cdd:pfam00955 195 SLSTENS----EINWSSlLTNSECtGSYGGTLVGSGCG----YVPDTALLSLILFLGTFWLAYFLKNFKNSPFFPTKVRR 266
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995  239 MVSDFAVFLTIFTMVIIDFLIGVPSPKLQVPSVFKPTRDDRGWIINPIGPNPWWTVIAAIIPALLCTILIFMDQQITAVI 318
Cdd:pfam00955 267 LISDFAVPIAILIMVLVDYFLGVYTPKLQVPSGFKPTDPDRGWLINPFGKNPWWLIFAAALPALLVTILIFMDQQITAVI 346
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995  319 INRKEHKLKKGCGYHLDLLMVAIMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFV 398
Cdd:pfam00955 347 VNRKENKLKKGSGYHLDLLVVAILNGICSLFGLPWMVAATVRSITHVNSLKVESETVAPGEKPKILGVREQRVTGLLVFI 426
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995  399 LMGCSVFMTAILKFIPMPVLYGVFLYMGVSSLQGIqsqfpflsrgngvtylseQFFDRLKLFGMPAKHQPDFIYLRHVPL 478
Cdd:pfam00955 427 LIGLSVFMTPVLKLIPMPVLYGVFLYMGVTSLNGI------------------QFFDRILLLFMPQKHQPDTHYLRHVPL 488

                  ....*....
gi 767975995  479 RKVHLFTLI 487
Cdd:pfam00955 489 RKVHLFTLI 497
ae TIGR00834
anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein ...
1-534 0e+00

anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein members of the AE family are found only in animals.They preferentially catalyze anion exchange (antiport) reactions, typically acting as HCO3-:Cl- antiporters, but also transporting a range of other inorganic and organic anions. Additionally, renal Na+:HCO3- cotransporters have been found to be members of the AE family. They catalyze the reabsorption of HCO3- in the renal proximal tubule. [Transport and binding proteins, Anions]


Pssm-ID: 273290 [Multi-domain]  Cd Length: 900  Bit Score: 645.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995    1 MSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQALTILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLW 80
Cdd:TIGR00834 383 LSPAITFGGLLGEKTRNMMGVSELLISTAVQGVLFALLAAQPLLVVGFSGPLLVFEEAFFSFCESNGLEYLVGRVWIGLW 462
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995   81 TAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSqlDHLslyYCRCTLPENPNNHTL 160
Cdd:TIGR00834 463 LVLLVLLLVATEGSFLVRYISRFTQEIFSFLISLIFIYETFSKLIKIFQEHPLQVFY--NTL---FCVPPKPQGPSVSAL 537
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995  161 qywkdhnivtaevhwanlTVSECQEMHGEFMGSACGhhgpYTPDVLFWSCILFFTTFILSSTLKTFKTSRYFPTRVRSMV 240
Cdd:TIGR00834 538 ------------------LEKDCSKLGGTLGGNNCR----FQPNTALLSLVLMLGTFFLAMFLRKFKNSRYFPGKARRLI 595
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995  241 SDFAVFLTIFTMVIIDFLIG-VPSPKLQVPSVFKPTR-DDRGWIINPIG---PNPWWTVIAAIIPALLCTILIFMDQQIT 315
Cdd:TIGR00834 596 GDFGVPISILIMVLVDIFIGdTYTQKLSVPSGLKVTNpSARGWFIPPLGenrPFPWWMMFAAALPALLVFILIFMEQQIT 675
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995  316 AVIINRKEHKLKKGCGYHLDLLMVAIMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLM 395
Cdd:TIGR00834 676 TLIVSKKERKLKKGSGFHLDLLLVVGMGGVAALFGLPWLSAATVRSVTHANALTVMSKASAPGEKAQIQEVREQRVTGLL 755
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995  396 IFVLMGCSVFMTAILKFIPMPVLYGVFLYMGVSSLQGIqsqfpflsrgngvtylseQFFDRLKLFGMPAKHQPDFIYLRH 475
Cdd:TIGR00834 756 VAVLVGLSILMEPILKRIPLAVLFGIFLYMGVTSLSGI------------------QLFDRLLLLLMPPKYHPDVPYVRR 817
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995  476 VPLRKVHLFTLIQLTCLVLLWVIKASPAAIVFPMMVLALVFVRKVMD-LCFSKRELSWLD 534
Cdd:TIGR00834 818 VKTWRMHLFTAIQILCLALLWVVKSTPASLAFPFVLILTVPLRRLLLpRLFTERELKCLD 877
 
Name Accession Description Interval E-value
HCO3_cotransp pfam00955
HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange ...
1-487 0e+00

HCO3- transporter family; This family contains Band 3 anion exchange proteins that exchange CL-/HCO3-. This family also includes cotransporters of Na+/HCO3-.


Pssm-ID: 425961  Cd Length: 497  Bit Score: 775.16  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995    1 MSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQALTILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLW 80
Cdd:pfam00955  41 LSPAITFGGLLGDATDGYIGVSESILSTAIGGIIFALFSGQPLTILGSTGPLLVFEKILYSFCKDNGLDYLSFRVWIGLW 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995   81 TAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQldhlslYYCRCTLPENPNNHTL 160
Cdd:pfam00955 121 LAFFLLLLVAFDASFLVRYITRFTEEIFALLISLIFIYEAFKKLFKIFKKYPLYYNYN------CTCVPPDNNNTTNSTL 194
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995  161 QYWKDHNivtaEVHWAN-LTVSEC-QEMHGEFMGSACGhhgpYTPDVLFWSCILFFTTFILSSTLKTFKTSRYFPTRVRS 238
Cdd:pfam00955 195 SLSTENS----EINWSSlLTNSECtGSYGGTLVGSGCG----YVPDTALLSLILFLGTFWLAYFLKNFKNSPFFPTKVRR 266
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995  239 MVSDFAVFLTIFTMVIIDFLIGVPSPKLQVPSVFKPTRDDRGWIINPIGPNPWWTVIAAIIPALLCTILIFMDQQITAVI 318
Cdd:pfam00955 267 LISDFAVPIAILIMVLVDYFLGVYTPKLQVPSGFKPTDPDRGWLINPFGKNPWWLIFAAALPALLVTILIFMDQQITAVI 346
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995  319 INRKEHKLKKGCGYHLDLLMVAIMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFV 398
Cdd:pfam00955 347 VNRKENKLKKGSGYHLDLLVVAILNGICSLFGLPWMVAATVRSITHVNSLKVESETVAPGEKPKILGVREQRVTGLLVFI 426
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995  399 LMGCSVFMTAILKFIPMPVLYGVFLYMGVSSLQGIqsqfpflsrgngvtylseQFFDRLKLFGMPAKHQPDFIYLRHVPL 478
Cdd:pfam00955 427 LIGLSVFMTPVLKLIPMPVLYGVFLYMGVTSLNGI------------------QFFDRILLLFMPQKHQPDTHYLRHVPL 488

                  ....*....
gi 767975995  479 RKVHLFTLI 487
Cdd:pfam00955 489 RKVHLFTLI 497
ae TIGR00834
anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein ...
1-534 0e+00

anion exchange protein; The Anion Exchanger (AE) Family (TC 2.A.31)Characterized protein members of the AE family are found only in animals.They preferentially catalyze anion exchange (antiport) reactions, typically acting as HCO3-:Cl- antiporters, but also transporting a range of other inorganic and organic anions. Additionally, renal Na+:HCO3- cotransporters have been found to be members of the AE family. They catalyze the reabsorption of HCO3- in the renal proximal tubule. [Transport and binding proteins, Anions]


Pssm-ID: 273290 [Multi-domain]  Cd Length: 900  Bit Score: 645.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995    1 MSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQALTILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLW 80
Cdd:TIGR00834 383 LSPAITFGGLLGEKTRNMMGVSELLISTAVQGVLFALLAAQPLLVVGFSGPLLVFEEAFFSFCESNGLEYLVGRVWIGLW 462
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995   81 TAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSqlDHLslyYCRCTLPENPNNHTL 160
Cdd:TIGR00834 463 LVLLVLLLVATEGSFLVRYISRFTQEIFSFLISLIFIYETFSKLIKIFQEHPLQVFY--NTL---FCVPPKPQGPSVSAL 537
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995  161 qywkdhnivtaevhwanlTVSECQEMHGEFMGSACGhhgpYTPDVLFWSCILFFTTFILSSTLKTFKTSRYFPTRVRSMV 240
Cdd:TIGR00834 538 ------------------LEKDCSKLGGTLGGNNCR----FQPNTALLSLVLMLGTFFLAMFLRKFKNSRYFPGKARRLI 595
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995  241 SDFAVFLTIFTMVIIDFLIG-VPSPKLQVPSVFKPTR-DDRGWIINPIG---PNPWWTVIAAIIPALLCTILIFMDQQIT 315
Cdd:TIGR00834 596 GDFGVPISILIMVLVDIFIGdTYTQKLSVPSGLKVTNpSARGWFIPPLGenrPFPWWMMFAAALPALLVFILIFMEQQIT 675
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995  316 AVIINRKEHKLKKGCGYHLDLLMVAIMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLM 395
Cdd:TIGR00834 676 TLIVSKKERKLKKGSGFHLDLLLVVGMGGVAALFGLPWLSAATVRSVTHANALTVMSKASAPGEKAQIQEVREQRVTGLL 755
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995  396 IFVLMGCSVFMTAILKFIPMPVLYGVFLYMGVSSLQGIqsqfpflsrgngvtylseQFFDRLKLFGMPAKHQPDFIYLRH 475
Cdd:TIGR00834 756 VAVLVGLSILMEPILKRIPLAVLFGIFLYMGVTSLSGI------------------QLFDRLLLLLMPPKYHPDVPYVRR 817
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767975995  476 VPLRKVHLFTLIQLTCLVLLWVIKASPAAIVFPMMVLALVFVRKVMD-LCFSKRELSWLD 534
Cdd:TIGR00834 818 VKTWRMHLFTAIQILCLALLWVVKSTPASLAFPFVLILTVPLRRLLLpRLFTERELKCLD 877
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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