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Conserved domains on  [gi|767961685|ref|XP_011537617|]
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lipase member J isoform X1 [Homo sapiens]

Protein Classification

lipase family protein( domain architecture ID 706631)

lipase family protein that may function as a lipase, catalyzing the hydrolysis of ester bonds of insoluble substrates such a triglycerides

EC:  3.1.1.-
Gene Ontology:  GO:0016298|GO:0016788|GO:0006629

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PLN02872 super family cl28691
triacylglycerol lipase
4-359 3.07e-51

triacylglycerol lipase


The actual alignment was detected with superfamily member PLN02872:

Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 175.44  E-value: 3.07e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961685   4 SQIISYWGYPDEEYDIVTEDGYILGLYRIpywrTDNNKNLAQRV--VVYLQHGLLTSASSWISNLPNNSLGFILADAGYD 81
Cdd:PLN02872  34 AQLIHPAGYSCTEHTIQTKDGYLLALQRV----SSRNPRLGSQRgpPVLLQHGLFMAGDAWFLNSPEQSLGFILADHGFD 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961685  82 VWMGNSRGNTWSRKHLYLETSSKEFWAFSFDEMAKYDLPASIDFtVKQTRQEEIFYVGHSQGTTIGFITFsTISKIAERI 161
Cdd:PLN02872 110 VWVGNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHY-VYSITNSKIFIVGHSQGTIMSLAAL-TQPNVVEMV 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961685 162 KIFFALAPVFSTKYLKSPLI-RMTY-KWKSIVMAFSgnkdfLPKTSFKKFIGSKLcplqiFDKIC---LNILFMMFGYDP 236
Cdd:PLN02872 188 EAAALLCPISYLDHVTAPLVlRMVFmHLDQMVVAMG-----IHQLNFRSDVLVKL-----LDSICeghMDCNDLLTSITG 257
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961685 237 KN--LNMSRLDVYFSHNPAGTSVQNMLHWSQLLNSTHLKAYDWGSPDlNLVHYNQTTSPLYNMTNMNVATAIW--NGKSD 312
Cdd:PLN02872 258 TNccFNASRIDYYLEYEPHPSSVKNLRHLFQMIRKGTFAHYDYGIFK-NLKLYGQVNPPAFDLSLIPKSLPLWmgYGGTD 336
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 767961685 313 LLADPEDVNILHSEITNHIYYKTISYYNHIDSLFGLDVYDQVYHEII 359
Cdd:PLN02872 337 GLADVTDVEHTLAELPSKPELLYLENYGHIDFLLSTSAKEDVYNHMI 383
 
Name Accession Description Interval E-value
PLN02872 PLN02872
triacylglycerol lipase
4-359 3.07e-51

triacylglycerol lipase


Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 175.44  E-value: 3.07e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961685   4 SQIISYWGYPDEEYDIVTEDGYILGLYRIpywrTDNNKNLAQRV--VVYLQHGLLTSASSWISNLPNNSLGFILADAGYD 81
Cdd:PLN02872  34 AQLIHPAGYSCTEHTIQTKDGYLLALQRV----SSRNPRLGSQRgpPVLLQHGLFMAGDAWFLNSPEQSLGFILADHGFD 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961685  82 VWMGNSRGNTWSRKHLYLETSSKEFWAFSFDEMAKYDLPASIDFtVKQTRQEEIFYVGHSQGTTIGFITFsTISKIAERI 161
Cdd:PLN02872 110 VWVGNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHY-VYSITNSKIFIVGHSQGTIMSLAAL-TQPNVVEMV 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961685 162 KIFFALAPVFSTKYLKSPLI-RMTY-KWKSIVMAFSgnkdfLPKTSFKKFIGSKLcplqiFDKIC---LNILFMMFGYDP 236
Cdd:PLN02872 188 EAAALLCPISYLDHVTAPLVlRMVFmHLDQMVVAMG-----IHQLNFRSDVLVKL-----LDSICeghMDCNDLLTSITG 257
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961685 237 KN--LNMSRLDVYFSHNPAGTSVQNMLHWSQLLNSTHLKAYDWGSPDlNLVHYNQTTSPLYNMTNMNVATAIW--NGKSD 312
Cdd:PLN02872 258 TNccFNASRIDYYLEYEPHPSSVKNLRHLFQMIRKGTFAHYDYGIFK-NLKLYGQVNPPAFDLSLIPKSLPLWmgYGGTD 336
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 767961685 313 LLADPEDVNILHSEITNHIYYKTISYYNHIDSLFGLDVYDQVYHEII 359
Cdd:PLN02872 337 GLADVTDVEHTLAELPSKPELLYLENYGHIDFLLSTSAKEDVYNHMI 383
Abhydro_lipase pfam04083
Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an ...
3-66 2.81e-23

Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an alpha/beta hydrolase domain.


Pssm-ID: 461162 [Multi-domain]  Cd Length: 63  Bit Score: 91.45  E-value: 2.81e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767961685    3 ISQIISYWGYPDEEYDIVTEDGYILGLYRIPYWRTdNNKNLAQRVVVYLQHGLLTSASSWISNL 66
Cdd:pfam04083   1 VSEIIRYYGYPVEEHEVTTEDGYILTLHRIPAGRN-NSNGKGGKPVVLLQHGLLASSDNWVTNG 63
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
13-187 2.38e-08

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 53.85  E-value: 2.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961685  13 PDEEYDIVTEDGYilglyRIPYWRTDNNKNlAQRVVVYLqHGLLTSASSWisnlpnNSLGFILADAGYDVWMGNSRGNTW 92
Cdd:COG2267    2 TRRLVTLPTRDGL-----RLRGRRWRPAGS-PRGTVVLV-HGLGEHSGRY------AELAEALAAAGYAVLAFDLRGHGR 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961685  93 SRKHLYLETSskefwafsFDEMAKyDLPASIDFtVKQTRQEEIFYVGHSQGttiGFITFSTISKIAERIKiffALApVFS 172
Cdd:COG2267   69 SDGPRGHVDS--------FDDYVD-DLRAALDA-LRARPGLPVVLLGHSMG---GLIALLYAARYPDRVA---GLV-LLA 131
                        170
                 ....*....|....*
gi 767961685 173 TKYLKSPLIRMTYKW 187
Cdd:COG2267  132 PAYRADPLLGPSARW 146
 
Name Accession Description Interval E-value
PLN02872 PLN02872
triacylglycerol lipase
4-359 3.07e-51

triacylglycerol lipase


Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 175.44  E-value: 3.07e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961685   4 SQIISYWGYPDEEYDIVTEDGYILGLYRIpywrTDNNKNLAQRV--VVYLQHGLLTSASSWISNLPNNSLGFILADAGYD 81
Cdd:PLN02872  34 AQLIHPAGYSCTEHTIQTKDGYLLALQRV----SSRNPRLGSQRgpPVLLQHGLFMAGDAWFLNSPEQSLGFILADHGFD 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961685  82 VWMGNSRGNTWSRKHLYLETSSKEFWAFSFDEMAKYDLPASIDFtVKQTRQEEIFYVGHSQGTTIGFITFsTISKIAERI 161
Cdd:PLN02872 110 VWVGNVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHY-VYSITNSKIFIVGHSQGTIMSLAAL-TQPNVVEMV 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961685 162 KIFFALAPVFSTKYLKSPLI-RMTY-KWKSIVMAFSgnkdfLPKTSFKKFIGSKLcplqiFDKIC---LNILFMMFGYDP 236
Cdd:PLN02872 188 EAAALLCPISYLDHVTAPLVlRMVFmHLDQMVVAMG-----IHQLNFRSDVLVKL-----LDSICeghMDCNDLLTSITG 257
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961685 237 KN--LNMSRLDVYFSHNPAGTSVQNMLHWSQLLNSTHLKAYDWGSPDlNLVHYNQTTSPLYNMTNMNVATAIW--NGKSD 312
Cdd:PLN02872 258 TNccFNASRIDYYLEYEPHPSSVKNLRHLFQMIRKGTFAHYDYGIFK-NLKLYGQVNPPAFDLSLIPKSLPLWmgYGGTD 336
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 767961685 313 LLADPEDVNILHSEITNHIYYKTISYYNHIDSLFGLDVYDQVYHEII 359
Cdd:PLN02872 337 GLADVTDVEHTLAELPSKPELLYLENYGHIDFLLSTSAKEDVYNHMI 383
Abhydro_lipase pfam04083
Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an ...
3-66 2.81e-23

Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an alpha/beta hydrolase domain.


Pssm-ID: 461162 [Multi-domain]  Cd Length: 63  Bit Score: 91.45  E-value: 2.81e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767961685    3 ISQIISYWGYPDEEYDIVTEDGYILGLYRIPYWRTdNNKNLAQRVVVYLQHGLLTSASSWISNL 66
Cdd:pfam04083   1 VSEIIRYYGYPVEEHEVTTEDGYILTLHRIPAGRN-NSNGKGGKPVVLLQHGLLASSDNWVTNG 63
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
48-347 3.02e-14

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 71.77  E-value: 3.02e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961685   48 VVYLQHGLLTSASSWISNLPNnslgfiLADAGYDVWMGNSRGNTWSRKHLYLETsskefwaFSFDEMAKYdlpasIDFTV 127
Cdd:pfam00561   2 PVLLLHGLPGSSDLWRKLAPA------LARDGFRVIALDLRGFGKSSRPKAQDD-------YRTDDLAED-----LEYIL 63
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961685  128 KQTRQEEIFYVGHSQGTTIGFITFstiSKIAERIKIFFALAPVfstkylkSPLIRMTYKWKSIVMAFSGNKDFLPKTSFK 207
Cdd:pfam00561  64 EALGLEKVNLVGHSMGGLIALAYA---AKYPDRVKALVLLGAL-------DPPHELDEADRFILALFPGFFDGFVADFAP 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961685  208 KFIGSKLCPLQIFDKICLNILFMMfgyDPKNLNMSRLDVYFSHNPAGTSVQNMLHWSQLLNSthlKAYDWGSPDlnlvhy 287
Cdd:pfam00561 134 NPLGRLVAKLLALLLLRLRLLKAL---PLLNKRFPSGDYALAKSLVTGALLFIETWSTELRA---KFLGRLDEP------ 201
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961685  288 nqttsplynmtnmnvaTAIWNGKSDLLADPEDVNILHsEITNHIYYKTISYYNHIDSLFG 347
Cdd:pfam00561 202 ----------------TLIIWGDQDPLVPPQALEKLA-QLFPNARLVVIPDAGHFAFLEG 244
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
13-187 2.38e-08

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 53.85  E-value: 2.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961685  13 PDEEYDIVTEDGYilglyRIPYWRTDNNKNlAQRVVVYLqHGLLTSASSWisnlpnNSLGFILADAGYDVWMGNSRGNTW 92
Cdd:COG2267    2 TRRLVTLPTRDGL-----RLRGRRWRPAGS-PRGTVVLV-HGLGEHSGRY------AELAEALAAAGYAVLAFDLRGHGR 68
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961685  93 SRKHLYLETSskefwafsFDEMAKyDLPASIDFtVKQTRQEEIFYVGHSQGttiGFITFSTISKIAERIKiffALApVFS 172
Cdd:COG2267   69 SDGPRGHVDS--------FDDYVD-DLRAALDA-LRARPGLPVVLLGHSMG---GLIALLYAARYPDRVA---GLV-LLA 131
                        170
                 ....*....|....*
gi 767961685 173 TKYLKSPLIRMTYKW 187
Cdd:COG2267  132 PAYRADPLLGPSARW 146
COG4757 COG4757
Predicted alpha/beta hydrolase [General function prediction only];
13-143 2.59e-03

Predicted alpha/beta hydrolase [General function prediction only];


Pssm-ID: 443790 [Multi-domain]  Cd Length: 289  Bit Score: 39.10  E-value: 2.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767961685  13 PDEEYDIVTEDGYILGLYRipyWRTDNnknlAQRVVVYLQHGLLTSAS------SWisnlpnnslgfiLADAGYDVWMGN 86
Cdd:COG4757    6 SPESVTITAADGYPLAARL---FPPAG----PPRAVVLINPATGVPQRfyrpfaRY------------LAERGFAVLTYD 66
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767961685  87 SRGNTWSRKhlyleTSSKEFwAFSFDEMAKYDLPASIDFTVKQTRQEEIFYVGHSQG 143
Cdd:COG4757   67 YRGIGLSRP-----GSLRGF-DAGYRDWGELDLPAVLDALRARFPGLPLLLVGHSLG 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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