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Conserved domains on  [gi|767969487|ref|XP_011540857|]
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transcriptional coactivator YAP1 isoform X5 [Homo sapiens]

Protein Classification

WW domain-containing protein( domain architecture ID 10078884)

WW domain-containing protein; the WW domain mediates protein-protein interaction via proline-rich motifs, such as PPxY; similar to mammalian Yes-associated protein 1 (YAP1) which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis

CATH:  2.20.70.10
Gene Ontology:  GO:0005515
PubMed:  22201747|9029943
SCOP:  3001621

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 53-85 9.49e-11

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


:

Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 56.07  E-value: 9.49e-11
                           10        20        30
                   ....*....|....*....|....*....|...
gi 767969487    53 PLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRL 85
Cdd:smart00456   1 PLPPGWEERKDPDGRPYYYNHETKETQWEKPRE 33
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 1-25 7.36e-06

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


:

Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 42.13  E-value: 7.36e-06
                         10        20
                 ....*....|....*....|....*
gi 767969487   1 MAKTSSGQRYFLNHIDQTTTWQDPR 25
Cdd:cd00201    6 ERWDPDGRVYYYNHNTKETQWEDPR 30
 
Name Accession Description Interval E-value
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 53-85 9.49e-11

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 56.07  E-value: 9.49e-11
                           10        20        30
                   ....*....|....*....|....*....|...
gi 767969487    53 PLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRL 85
Cdd:smart00456   1 PLPPGWEERKDPDGRPYYYNHETKETQWEKPRE 33
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 54-83 1.58e-10

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 55.20  E-value: 1.58e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 767969487   54 LPDGWEQAMTQDGEIYYINHKNKTTSWLDP 83
Cdd:pfam00397   1 LPPGWEERWDPDGRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 55-85 2.20e-10

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 54.84  E-value: 2.20e-10
                         10        20        30
                 ....*....|....*....|....*....|.
gi 767969487  55 PDGWEQAMTQDGEIYYINHKNKTTSWLDPRL 85
Cdd:cd00201    1 PPGWEERWDPDGRVYYYNHNTKETQWEDPRE 31
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 1-25 7.36e-06

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 42.13  E-value: 7.36e-06
                         10        20
                 ....*....|....*....|....*
gi 767969487   1 MAKTSSGQRYFLNHIDQTTTWQDPR 25
Cdd:cd00201    6 ERWDPDGRVYYYNHNTKETQWEDPR 30
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 1-25 1.31e-04

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 38.74  E-value: 1.31e-04
                           10        20
                   ....*....|....*....|....*
gi 767969487     1 MAKTSSGQRYFLNHIDQTTTWQDPR 25
Cdd:smart00456   8 ERKDPDGRPYYYNHETKETQWEKPR 32
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 1-24 5.42e-04

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 36.71  E-value: 5.42e-04
                          10        20
                  ....*....|....*....|....
gi 767969487    1 MAKTSSGQRYFLNHIDQTTTWQDP 24
Cdd:pfam00397   7 ERWDPDGRVYYYNHETGETQWEKP 30
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
4-90 5.76e-04

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 41.68  E-value: 5.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969487   4 TSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDP 83
Cdd:COG5021  397 EDLGQFLFSDFLTSSSTYEDLRREQLGRESDESFYVASNVQQQRASREGPLLSGWKTRLNNLYRFYFVEHRKKTLTKNDS 476


                 ....*..
gi 767969487  84 RLDPRFG 90
Cdd:COG5021  477 RLGSFIS 483
 
Name Accession Description Interval E-value
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 53-85 9.49e-11

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 56.07  E-value: 9.49e-11
                           10        20        30
                   ....*....|....*....|....*....|...
gi 767969487    53 PLPDGWEQAMTQDGEIYYINHKNKTTSWLDPRL 85
Cdd:smart00456   1 PLPPGWEERKDPDGRPYYYNHETKETQWEKPRE 33
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 54-83 1.58e-10

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 55.20  E-value: 1.58e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 767969487   54 LPDGWEQAMTQDGEIYYINHKNKTTSWLDP 83
Cdd:pfam00397   1 LPPGWEERWDPDGRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 55-85 2.20e-10

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 54.84  E-value: 2.20e-10
                         10        20        30
                 ....*....|....*....|....*....|.
gi 767969487  55 PDGWEQAMTQDGEIYYINHKNKTTSWLDPRL 85
Cdd:cd00201    1 PPGWEERWDPDGRVYYYNHNTKETQWEDPRE 31
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 1-25 7.36e-06

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 42.13  E-value: 7.36e-06
                         10        20
                 ....*....|....*....|....*
gi 767969487   1 MAKTSSGQRYFLNHIDQTTTWQDPR 25
Cdd:cd00201    6 ERWDPDGRVYYYNHNTKETQWEDPR 30
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 1-25 1.31e-04

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 38.74  E-value: 1.31e-04
                           10        20
                   ....*....|....*....|....*
gi 767969487     1 MAKTSSGQRYFLNHIDQTTTWQDPR 25
Cdd:smart00456   8 ERKDPDGRPYYYNHETKETQWEKPR 32
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 1-24 5.42e-04

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 36.71  E-value: 5.42e-04
                          10        20
                  ....*....|....*....|....
gi 767969487    1 MAKTSSGQRYFLNHIDQTTTWQDP 24
Cdd:pfam00397   7 ERWDPDGRVYYYNHETGETQWEKP 30
HUL4 COG5021
Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];
4-90 5.76e-04

Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227354 [Multi-domain]  Cd Length: 872  Bit Score: 41.68  E-value: 5.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767969487   4 TSSGQRYFLNHIDQTTTWQDPRKAMLSQMNVTAPTSPPVQQNMMNSASGPLPDGWEQAMTQDGEIYYINHKNKTTSWLDP 83
Cdd:COG5021  397 EDLGQFLFSDFLTSSSTYEDLRREQLGRESDESFYVASNVQQQRASREGPLLSGWKTRLNNLYRFYFVEHRKKTLTKNDS 476


                 ....*..
gi 767969487  84 RLDPRFG 90
Cdd:COG5021  477 RLGSFIS 483
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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