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Conserved domains on  [gi|767936479|ref|XP_011541925|]
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ankyrin repeat and death domain-containing protein 1B isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
55-244 9.30e-34

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 126.99  E-value: 9.30e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479  55 EDTAVAGHELPERGHVEMIEKLTFLNLHTSEKDKGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNG 134
Cdd:COG0666   52 ALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 135 HASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCD 214
Cdd:COG0666  132 NLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD 211

                        170       180       190
                 ....*....|....*....|....*....|
gi 767936479 215 LKAVDKQGKTALAVASRSNHSLVVGMLIKA 244
Cdd:COG0666  212 VNAKDNDGKTALDLAAENGNLEIVKLLLEA 241
Death super family cl47563
Death domain;
295-365 6.43e-03

Death domain;


The actual alignment was detected with superfamily member pfam00531:

Pssm-ID: 459845 [Multi-domain]  Cd Length: 86  Bit Score: 35.42  E-value: 6.43e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767936479  295 NEWQRLARSWNFTDDQIRAIEEQwsgNESFREHGHRALLIWlhgtLMTQGDPA--KQLYEELVHAGFPKLAEK 365
Cdd:pfam00531  16 KDWRELARKLGLSENEIDEIESE---NPRLRSQTYELLRLW----EQREGKNAtvGTLLEALRKLGRRDAAEK 81
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
55-244 9.30e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 126.99  E-value: 9.30e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479  55 EDTAVAGHELPERGHVEMIEKLTFLNLHTSEKDKGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNG 134
Cdd:COG0666   52 ALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 135 HASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCD 214
Cdd:COG0666  132 NLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD 211

                        170       180       190
                 ....*....|....*....|....*....|
gi 767936479 215 LKAVDKQGKTALAVASRSNHSLVVGMLIKA 244
Cdd:COG0666  212 VNAKDNDGKTALDLAAENGNLEIVKLLLEA 241
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 62-243 5.12e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 82.02  E-value: 5.12e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479  62 HELPERGHVEMIEKLTFLNLHTSEKDKGGNTALHLAAKHGHS-----PAVQVLLAQWQDINEMNELNISSLQIA--TRNG 134
Cdd:PHA03100  40 YLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPLLYAisKKSN 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 135 HASLVNFLLSENVDLHQKVEPKESPLHLVVINNHI------------------TVVNSLLSAQHDIDILNQKQQTPLHVA 196
Cdd:PHA03100 120 SYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIdlkilkllidkgvdinakNRVNYLLSYGVPINIKDVYGFTPLHYA 199

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 767936479 197 ADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 243
Cdd:PHA03100 200 VYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLN 246
Ank_2 pfam12796
Ankyrin repeats (3 copies);
127-219 2.16e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 73.61  E-value: 2.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479  127 LQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVnSLLSAQHDIDILNQkQQTPLHVAADRGNVELVE 206
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIV-KLLLEHADVNLKDN-GRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 767936479  207 TLLKAGCDLKAVD 219
Cdd:pfam12796  79 LLLEKGADINVKD 91
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 81-226 5.83e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.55  E-value: 5.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479  81 LHTSEKDKGGNTALHLAAKHGHSPAVQVLLAQWQ-DINEMNELNISSLQIATRNGHASLVNFLLSE-----NV----DLH 150
Cdd:cd22192    8 LHLLQQKRISESPLLLAAKENDVQAIKKLLKCPScDLFQRGALGETALHVAALYDNLEAAVVLMEAapelvNEpmtsDLY 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 151 QKvepkESPLHLVVINNHITVVNSLLSAQHDID---------ILNQKQ-----QTPLHVAADRGNVELVETLLKAGCDLK 216
Cdd:cd22192   88 QG----ETALHIAVVNQNLNLVRELIARGADVVspratgtffRPGPKNliyygEHPLSFAACVGNEEIVRLLIEHGADIR 163

                        170
                 ....*....|
gi 767936479 217 AVDKQGKTAL 226
Cdd:cd22192  164 AQDSLGNTVL 173
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 97-217 1.52e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 43.92  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479   97 AAKHGHSPAVQVLLAQWQ--DINEMNELNISSLQ-IATRNGHASLVNFLLSENvdlhQKVEPKESPLHLVViNNHITVVN 173
Cdd:TIGR00870  24 AAERGDLASVYRDLEEPKklNINCPDRLGRSALFvAAIENENLELTELLLNLS----CRGAVGDTLLHAIS-LEYVDAVE 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767936479  174 SLLS--AQHDIDILN------------QKQQTPLHVAADRGNVELVETLLKAGCDLKA 217
Cdd:TIGR00870  99 AILLhlLAAFRKSGPlelandqytsefTPGITALHLAAHRQNYEIVKLLLERGASVPA 156
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 191-215 6.18e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 6.18e-04
                           10        20
                   ....*....|....*....|....*
gi 767936479   191 TPLHVAADRGNVELVETLLKAGCDL 215
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADI 28
Death pfam00531
Death domain;
295-365 6.43e-03

Death domain;


Pssm-ID: 459845 [Multi-domain]  Cd Length: 86  Bit Score: 35.42  E-value: 6.43e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767936479  295 NEWQRLARSWNFTDDQIRAIEEQwsgNESFREHGHRALLIWlhgtLMTQGDPA--KQLYEELVHAGFPKLAEK 365
Cdd:pfam00531  16 KDWRELARKLGLSENEIDEIESE---NPRLRSQTYELLRLW----EQREGKNAtvGTLLEALRKLGRRDAAEK 81
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
55-244 9.30e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 126.99  E-value: 9.30e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479  55 EDTAVAGHELPERGHVEMIEKLTFLNLHTSEKDKGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNG 134
Cdd:COG0666   52 ALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNG 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 135 HASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCD 214
Cdd:COG0666  132 NLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD 211

                        170       180       190
                 ....*....|....*....|....*....|
gi 767936479 215 LKAVDKQGKTALAVASRSNHSLVVGMLIKA 244
Cdd:COG0666  212 VNAKDNDGKTALDLAAENGNLEIVKLLLEA 241
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
56-244 1.30e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 118.52  E-value: 1.30e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479  56 DTAVAGHELPERGHVEMIEKLTFLNLHTSEKDKGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGH 135
Cdd:COG0666   20 LLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGD 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 136 ASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDL 215
Cdd:COG0666  100 LEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADV 179

                        170       180
                 ....*....|....*....|....*....
gi 767936479 216 KAVDKQGKTALAVASRSNHSLVVGMLIKA 244
Cdd:COG0666  180 NARDNDGETPLHLAAENGHLEIVKLLLEA 208
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
66-244 1.27e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 110.43  E-value: 1.27e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479  66 ERGHVEMIEKLTFLNLHTSEKDKGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSE 145
Cdd:COG0666   96 RNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEA 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 146 NVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTA 225
Cdd:COG0666  176 GADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTA 255

                        170
                 ....*....|....*....
gi 767936479 226 LAVASRSNHSLVVGMLIKA 244
Cdd:COG0666  256 LLLAAAAGAALIVKLLLLA 274
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
70-244 1.25e-21

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 93.87  E-value: 1.25e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479  70 VEMIEKLTFLNLHTSEKDKGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDL 149
Cdd:COG0666    1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 150 HQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVA 229
Cdd:COG0666   81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160

                        170
                 ....*....|....*
gi 767936479 230 SRSNHSLVVGMLIKA 244
Cdd:COG0666  161 AANGNLEIVKLLLEA 175
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
66-226 4.30e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 86.55  E-value: 4.30e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479  66 ERGHVEMIEKLTFLNLHTSEKDKGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSE 145
Cdd:COG0666  129 YNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEA 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 146 NVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTA 225
Cdd:COG0666  209 GADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288


                 .
gi 767936479 226 L 226
Cdd:COG0666  289 L 289
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 62-243 5.12e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 82.02  E-value: 5.12e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479  62 HELPERGHVEMIEKLTFLNLHTSEKDKGGNTALHLAAKHGHS-----PAVQVLLAQWQDINEMNELNISSLQIA--TRNG 134
Cdd:PHA03100  40 YLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPLLYAisKKSN 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 135 HASLVNFLLSENVDLHQKVEPKESPLHLVVINNHI------------------TVVNSLLSAQHDIDILNQKQQTPLHVA 196
Cdd:PHA03100 120 SYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIdlkilkllidkgvdinakNRVNYLLSYGVPINIKDVYGFTPLHYA 199

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 767936479 197 ADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 243
Cdd:PHA03100 200 VYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLN 246
Ank_2 pfam12796
Ankyrin repeats (3 copies);
127-219 2.16e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 73.61  E-value: 2.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479  127 LQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVnSLLSAQHDIDILNQkQQTPLHVAADRGNVELVE 206
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIV-KLLLEHADVNLKDN-GRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 767936479  207 TLLKAGCDLKAVD 219
Cdd:pfam12796  79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
160-243 1.87e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.22  E-value: 1.87e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479  160 LHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKaGCDLKAVDkQGKTALAVASRSNHSLVVG 239
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78


                  ....
gi 767936479  240 MLIK 243
Cdd:pfam12796  79 LLLE 82
Ank_2 pfam12796
Ankyrin repeats (3 copies);
94-186 4.20e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 67.45  E-value: 4.20e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479   94 LHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLsENVDLhQKVEPKESPLHLVVINNHITVVN 173
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADV-NLKDNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 767936479  174 SLLSAQHDIDILN 186
Cdd:pfam12796  79 LLLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 66-221 1.25e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 68.54  E-value: 1.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479  66 ERGHVEMIEKLTFLNLHTSEKDKGGNTALHLAAKHGH--SPAVQVLLAQWQDINEMNElnisslqiatrnghaslVNFLL 143
Cdd:PHA03100 117 KSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDINAKNR-----------------VNYLL 179

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767936479 144 SENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQ 221
Cdd:PHA03100 180 SYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIET 257
PHA03095 PHA03095
ankyrin-like protein; Provisional
 70-243 8.08e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 66.20  E-value: 8.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479  70 VEMIEKLTFLNLHTSEKDKGGNTALH--LAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHAS--LVNFLLSE 145
Cdd:PHA03095  97 LDVIKLLIKAGADVNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNANveLLRLLIDA 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 146 NVD-----------LHQ-KVEPKES-----------------------PLHLVVINNHI--TVVNSLLSAQHDIDILNQK 188
Cdd:PHA03095 177 GADvyavddrfrslLHHhLQSFKPRarivreliragcdpaatdmlgntPLHSMATGSSCkrSLVLPLLIAGISINARNRY 256

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767936479 189 QQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 243
Cdd:PHA03095 257 GQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALA 311
Ank_2 pfam12796
Ankyrin repeats (3 copies);
66-152 1.07e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.51  E-value: 1.07e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479   66 ERGHVEMIEKLTFLNLHTSEKDKGGNTALHLAAKHGHSPAVQVLLAQWqDINEMNELNiSSLQIATRNGHASLVNFLLSE 145
Cdd:pfam12796   6 KNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHA-DVNLKDNGR-TALHYAARSGHLEIVKLLLEK 83


                  ....*..
gi 767936479  146 NVDLHQK 152
Cdd:pfam12796  84 GADINVK 90
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 72-242 2.71e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 65.08  E-value: 2.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479  72 MIEKLTFLNLHTSEKDKGGNTALHLAAKHGH-SPAVQVLLAQWQDINEMNELNISSL-QIATRNGHASLVNFLLSENVDL 149
Cdd:PHA02876 289 LVPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLhQASTLDRNKDIVITLLELGANV 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 150 HQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVEL-VETLLKAGCDLKAVDKQGKTALAV 228
Cdd:PHA02876 369 NARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPYMsVKTLIDRGANVNSKNKDLSTPLHY 448

                        170
                 ....*....|....*
gi 767936479 229 ASRSNHSL-VVGMLI 242
Cdd:PHA02876 449 ACKKNCKLdVIEMLL 463
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 68-247 4.64e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 63.83  E-value: 4.64e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479  68 GHVEMIEKL-----TFLNLHTSEKdkggNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFL 142
Cdd:PHA02874  12 GDIEAIEKIiknkgNCINISVDET----TTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 143 LSENVDlhqkvepkESPLHLVVINNHItvVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQG 222
Cdd:PHA02874  88 IDNGVD--------TSILPIPCIEKDM--IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNG 157

                        170       180
                 ....*....|....*....|....*
gi 767936479 223 KTALAVASRSNHSLVVGMLIKAERY 247
Cdd:PHA02874 158 CYPIHIAIKHNFFDIIKLLLEKGAY 182
PHA03095 PHA03095
ankyrin-like protein; Provisional
 72-243 3.68e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 61.19  E-value: 3.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479  72 MIEKLTFLNLhtseKDKGGNTALHLAAKHGHS-PAVQVLLAQWQDINEMNELNISSLQI--ATRNGHASLVNFLLSENVD 148
Cdd:PHA03095  69 LLEAGADVNA----PERCGFTPLHLYLYNATTlDVIKLLIKAGADVNAKDKVGRTPLHVylSGFNINPKVIRLLLRKGAD 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 149 LHQKVEPKESPLHLVVINNHITV--VNSLLSAQHDIDILNQKQQTPLHVAAD--RGNVELVETLLKAGCDLKAVDKQGKT 224
Cdd:PHA03095 145 VNALDLYGMTPLAVLLKSRNANVelLRLLIDAGADVYAVDDRFRSLLHHHLQsfKPRARIVRELIRAGCDPAATDMLGNT 224

                        170       180
                 ....*....|....*....|..
gi 767936479 225 AL---AVASRSNHSLVVGMLIK 243
Cdd:PHA03095 225 PLhsmATGSSCKRSLVLPLLIA 246
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 70-243 6.63e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 60.39  E-value: 6.63e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479  70 VEMIEKLTFLNLHTSEKDKGGNTALHLAAKHGHSPAVQVLLAQWQDINEM-NELNISSLQIATRNGHASLVNFLLSENVD 148
Cdd:PHA02875  48 SEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVfYKDGMTPLHLATILKKLDIMKLLIARGAD 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 149 LHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGK-TALA 227
Cdd:PHA02875 128 PDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCvAALC 207

                        170
                 ....*....|....*.
gi 767936479 228 VASRSNHSLVVGMLIK 243
Cdd:PHA02875 208 YAIENNKIDIVRLFIK 223
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 142-264 8.64e-09

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 57.19  E-value: 8.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 142 LLSENVDLHQKVEPKESPLHLVVINNHiTVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQ 221
Cdd:PLN03192 512 LLGDNGGEHDDPNMASNLLTVASTGNA-ALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDAN 590

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 767936479 222 GKTALAVASRSNHSLVVGMLikaeryyawreEHHESIRDPSTG 264
Cdd:PLN03192 591 GNTALWNAISAKHHKIFRIL-----------YHFASISDPHAA 622
Ank_5 pfam13857
Ankyrin repeats (many copies);
181-229 9.28e-09

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 51.19  E-value: 9.28e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 767936479  181 DIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVA 229
Cdd:pfam13857   8 DLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
90-143 8.86e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.42  E-value: 8.86e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767936479   90 GNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLL 143
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 68-242 2.02e-07

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 52.95  E-value: 2.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479  68 GHVEMIEKLTFLNLHTSEKDKGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLsenv 147
Cdd:PLN03192 536 GNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY---- 611

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 148 dlhqkvepkesplHLVVINNHitvvnsllSAQHDIdilnqkqqtpLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALA 227
Cdd:PLN03192 612 -------------HFASISDP--------HAAGDL----------LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQ 660

                        170
                 ....*....|....*
gi 767936479 228 VASRSNHSLVVGMLI 242
Cdd:PLN03192 661 VAMAEDHVDMVRLLI 675
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 62-272 2.51e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 52.57  E-value: 2.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479  62 HELPERGHVEMIEKLTFLNLHTSEKDKGGNTALHLAAKHGHSPAVQVLLA---------QWQDINEM------------- 119
Cdd:PHA02878  42 HQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRsinkcsvfyTLVAIKDAfnnrnveifkiil 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 120 -----NELNISSLQIATRNG----HASLVNFLLSENVDLHQKVEPK-ESPLHLVVINNHITVVNSLLSAQHDIDILNQKQ 189
Cdd:PHA02878 122 tnrykNIQTIDLVYIDKKSKddiiEAEITKLLLSYGADINMKDRHKgNTALHYATENKDQRLTELLLSYGANVNIPDKTN 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 190 QTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVV-------GMLIKAERYYAWREEHHESIRDPS 262
Cdd:PHA02878 202 NSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYCKDYDIlklllehGVDVNAKSYILGLTALHSSIKSER 281

                        250
                 ....*....|.
gi 767936479 263 -TGFTLTFKQD 272
Cdd:PHA02878 282 kLKLLLEYGAD 292
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 66-229 2.59e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 52.27  E-value: 2.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479  66 ERGHVEMIEKLTFLNLHTSEKDKGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSE 145
Cdd:PHA02874 133 KKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDH 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 146 NVDLHQKVEPKESPLHLVVINNHITVvnSLLSAQHDIDILNQKQQTPLHVAADRG-NVELVETLLKAGCDLKAVDKQGKT 224
Cdd:PHA02874 213 GNHIMNKCKNGFTPLHNAIIHNRSAI--ELLINNASINDQDIDGSTPLHHAINPPcDIDIIDILLYHKADISIKDNKGEN 290


                 ....*
gi 767936479 225 ALAVA 229
Cdd:PHA02874 291 PIDTA 295
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 175-243 2.98e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 52.21  E-value: 2.98e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767936479 175 LLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLIK 243
Cdd:PTZ00322 101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 81-226 5.83e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 51.55  E-value: 5.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479  81 LHTSEKDKGGNTALHLAAKHGHSPAVQVLLAQWQ-DINEMNELNISSLQIATRNGHASLVNFLLSE-----NV----DLH 150
Cdd:cd22192    8 LHLLQQKRISESPLLLAAKENDVQAIKKLLKCPScDLFQRGALGETALHVAALYDNLEAAVVLMEAapelvNEpmtsDLY 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 151 QKvepkESPLHLVVINNHITVVNSLLSAQHDID---------ILNQKQ-----QTPLHVAADRGNVELVETLLKAGCDLK 216
Cdd:cd22192   88 QG----ETALHIAVVNQNLNLVRELIARGADVVspratgtffRPGPKNliyygEHPLSFAACVGNEEIVRLLIEHGADIR 163

                        170
                 ....*....|
gi 767936479 217 AVDKQGKTAL 226
Cdd:cd22192  164 AQDSLGNTVL 173
PHA03095 PHA03095
ankyrin-like protein; Provisional
 90-244 6.24e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 51.18  E-value: 6.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479  90 GNTALHLAAKHGHSP---AVQVLLAQWQDINEMNELNISSLQIATRNGH-ASLVNFLLSENVDLHQKVEPKESPLH--LV 163
Cdd:PHA03095  47 GKTPLHLYLHYSSEKvkdIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLHvyLS 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 164 VINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGN--VELVETLLKAGCDLKAVDKQGKTAL---AVASRSNHSlVV 238
Cdd:PHA03095 127 GFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNanVELLRLLIDAGADVYAVDDRFRSLLhhhLQSFKPRAR-IV 205


                 ....*.
gi 767936479 239 GMLIKA 244
Cdd:PHA03095 206 RELIRA 211
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 86-260 6.40e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 51.22  E-value: 6.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479  86 KDKGGNTALHLAAKHGHSPAVQVLLAQWQDIN------------EMNELNISSLQIATRN------GHASLVNFLlsENV 147
Cdd:PHA02876 174 KDIYCITPIHYAAERGNAKMVNLLLSYGADVNiialddlsvlecAVDSKNIDTIKAIIDNrsninkNDLSLLKAI--RNE 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 148 DLHQKV-------------EPKESPLHLVVINNHIT-VVNSLLSAQHDIDILNQKQQTPLHVAADRG-NVELVETLLKAG 212
Cdd:PHA02876 252 DLETSLllydagfsvnsidDCKNTPLHHASQAPSLSrLVPKLLERGADVNAKNIKGETPLYLMAKNGyDTENIRTLIMLG 331

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767936479 213 CDLKAVDKQGKTALAVASR--SNHSLVVGML-----IKAERYYAWREEHHESIRD 260
Cdd:PHA02876 332 ADVNAADRLYITPLHQASTldRNKDIVITLLelganVNARDYCDKTPIHYAAVRN 386
PHA03095 PHA03095
ankyrin-like protein; Provisional
 106-244 9.21e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.41  E-value: 9.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 106 VQVLLAQWQDINEMNELNISSLQIATRNGH---ASLVNFLLSENVDLHQKVEPKESPLHLVVIN-NHITVVNSLLSAQHD 181
Cdd:PHA03095  30 VRRLLAAGADVNFRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNaTTLDVIKLLIKAGAD 109

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767936479 182 IDILNQKQQTPLHV--AADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRS-NHSL-VVGMLIKA 244
Cdd:PHA03095 110 VNAKDKVGRTPLHVylSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSrNANVeLLRLLIDA 176
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 70-242 2.08e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 49.22  E-value: 2.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479  70 VEMIEKLTFLNLHTSEK--DKG---------GNTALHLAAKHGHSPAVQvLLAQWQDINEMNELNISS-LQIATRNGHAS 137
Cdd:PHA02875   4 VALCDAILFGELDIARRllDIGinpnfeiydGISPIKLAMKFRDSEAIK-LLMKHGAIPDVKYPDIESeLHDAVEEGDVK 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 138 LVNFLLSENVDLHQKVEPK-ESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLK 216
Cdd:PHA02875  83 AVEELLDLGKFADDVFYKDgMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLD 162

                        170       180
                 ....*....|....*....|....*.
gi 767936479 217 AVDKQGKTALAVASRSNHSLVVGMLI 242
Cdd:PHA02875 163 IEDCCGCTPLIIAMAKGDIAICKMLL 188
Ank_4 pfam13637
Ankyrin repeats (many copies);
191-242 2.88e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.19  E-value: 2.88e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767936479  191 TPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLI 242
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_2 pfam12796
Ankyrin repeats (3 copies);
66-120 6.11e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 44.34  E-value: 6.11e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767936479   66 ERGHVEMIEKLtfLNLHTSEKDKGGNTALHLAAKHGHSPAVQVLLAQWQDINEMN 120
Cdd:pfam12796  39 KNGHLEIVKLL--LEHADVNLKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
Ank_4 pfam13637
Ankyrin repeats (many copies);
158-209 1.08e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.26  E-value: 1.08e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 767936479  158 SPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLL 209
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 116-242 1.34e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 46.98  E-value: 1.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 116 INEMNELNISSLQIATRNGHAS-LVNFLLSENVDLHQKVEPKESPLHLVVINNHITV-VNSLLSAQHDIDILNQKQQTPL 193
Cdd:PHA02876 266 VNSIDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAKNIKGETPLYLMAKNGYDTEnIRTLIMLGADVNAADRLYITPL 345

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767936479 194 HVAA--DRgNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLVVGMLI 242
Cdd:PHA02876 346 HQAStlDR-NKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLL 395
Ank_5 pfam13857
Ankyrin repeats (many copies);
86-130 1.40e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 42.33  E-value: 1.40e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 767936479   86 KDKGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIA 130
Cdd:pfam13857  12 LDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 87-196 3.58e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 45.64  E-value: 3.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479  87 DKGGNTALHLAAKHGHSPAVQVLLAQWQDINEMNELNISSLQIAT-RNGHASLVNFLLSENVDLHQKVEPKE-SPLHLVV 164
Cdd:PHA02878 198 DKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVgYCKDYDILKLLLEHGVDVNAKSYILGlTALHSSI 277

                         90       100       110
                 ....*....|....*....|....*....|..
gi 767936479 165 INNHITvvNSLLSAQHDIDILNQKQQTPLHVA 196
Cdd:PHA02878 278 KSERKL--KLLLEYGADINSLNSYKLTPLSSA 307
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 106-242 3.93e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 45.34  E-value: 3.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 106 VQVLLAQWQDINEMNELNISSLQIATRNGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDIL 185
Cdd:PHA02874 107 IKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVK 186

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767936479 186 NQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSlVVGMLI 242
Cdd:PHA02874 187 DNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRS-AIELLI 242
Ank_4 pfam13637
Ankyrin repeats (many copies);
62-110 8.80e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 8.80e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 767936479   62 HELPERGHVEMIEKLTFLNLHTSEKDKGGNTALHLAAKHGHSPAVQVLL 110
Cdd:pfam13637   6 HAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 190-220 9.64e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.19  E-value: 9.64e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 767936479  190 QTPLHVAADR-GNVELVETLLKAGCDLKAVDK 220
Cdd:pfam00023   3 NTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 97-217 1.52e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 43.92  E-value: 1.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479   97 AAKHGHSPAVQVLLAQWQ--DINEMNELNISSLQ-IATRNGHASLVNFLLSENvdlhQKVEPKESPLHLVViNNHITVVN 173
Cdd:TIGR00870  24 AAERGDLASVYRDLEEPKklNINCPDRLGRSALFvAAIENENLELTELLLNLS----CRGAVGDTLLHAIS-LEYVDAVE 98

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767936479  174 SLLS--AQHDIDILN------------QKQQTPLHVAADRGNVELVETLLKAGCDLKA 217
Cdd:TIGR00870  99 AILLhlLAAFRKSGPlelandqytsefTPGITALHLAAHRQNYEIVKLLLERGASVPA 156
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 133-210 2.05e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 43.35  E-value: 2.05e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767936479 133 NGHASLVNFLLSENVDLHQKVEPKESPLHLVVINNHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLK 210
Cdd:PTZ00322  92 SGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 191-215 6.18e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 6.18e-04
                           10        20
                   ....*....|....*....|....*
gi 767936479   191 TPLHVAADRGNVELVETLLKAGCDL 215
Cdd:smart00248   4 TPLHLAAENGNLEVVKLLLDKGADI 28
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 90-118 8.39e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.47  E-value: 8.39e-04
                          10        20
                  ....*....|....*....|....*....
gi 767936479   90 GNTALHLAAKHGHSPAVQVLLAQWQDINE 118
Cdd:pfam13606   2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 190-217 1.33e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.08  E-value: 1.33e-03
                          10        20
                  ....*....|....*....|....*...
gi 767936479  190 QTPLHVAADRGNVELVETLLKAGCDLKA 217
Cdd:pfam13606   3 NTPLHLAARNGRLEIVKLLLENGADINA 30
PHA02791 PHA02791
ankyrin-like protein; Provisional
 158-251 2.14e-03

ankyrin-like protein; Provisional


Pssm-ID: 165154 [Multi-domain]  Cd Length: 284  Bit Score: 39.64  E-value: 2.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 158 SPLHLVVINNHITVVNSLLSAQHDIDILnqKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNHSLV 237
Cdd:PHA02791  32 SALYYAIADNNVRLVCTLLNAGALKNLL--ENEFPLHQAATLEDTKIVKILLFSGMDDSQFDDKGNTALYYAVDSGNMQT 109

                         90
                 ....*....|....
gi 767936479 238 VGMLIKAEryyaWR 251
Cdd:PHA02791 110 VKLFVKKN----WR 119
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 106-237 2.27e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 40.11  E-value: 2.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 106 VQVLLAQWQDINEMNEL-NISSLQIATRNG----HASLVNFLLSENVDLHQKVEPKESPL------HLVVINNHITVVNS 174
Cdd:PHA02989 163 IKILLSFGVNLFEKTSLyGLTPMNIYLRNDidviSIKVIKYLIKKGVNIETNNNGSESVLesfldnNKILSKKEFKVLNF 242

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767936479 175 LLSaQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVA-SRSNHSLV 237
Cdd:PHA02989 243 ILK-YIKINKKDKKGFNPLLISAKVDNYEAFNYLLKLGDDIYNVSKDGDTVLTYAiKHGNIDML 305
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 116-226 2.28e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 39.03  E-value: 2.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936479 116 INEMNELNISSLQIATRNGHASL--VNFLLSENVDLHQKVEPKE-SPLH-LVVINNHIT--VVNSLLSAQHDIDILNQKQ 189
Cdd:PHA02859  44 VNDCNDLYETPIFSCLEKDKVNVeiLKFLIENGADVNFKTRDNNlSALHhYLSFNKNVEpeILKILIDSGSSITEEDEDG 123

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 767936479 190 QTPLHVAADRGNV--ELVETLLKAGCDLKAVDKQGKTAL 226
Cdd:PHA02859 124 KNLLHMYMCNFNVriNVIKLLIDSGVSFLNKDFDNNNIL 162
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 167-234 3.13e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 39.66  E-value: 3.13e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767936479 167 NHITVVNSLLSAQHDIDILNQKQQTPLHVAADRGNVELVETLLKAGCDLKAVDKQGKTALAVASRSNH 234
Cdd:PHA02876 156 DELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKN 223
Death pfam00531
Death domain;
295-365 6.43e-03

Death domain;


Pssm-ID: 459845 [Multi-domain]  Cd Length: 86  Bit Score: 35.42  E-value: 6.43e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767936479  295 NEWQRLARSWNFTDDQIRAIEEQwsgNESFREHGHRALLIWlhgtLMTQGDPA--KQLYEELVHAGFPKLAEK 365
Cdd:pfam00531  16 KDWRELARKLGLSENEIDEIESE---NPRLRSQTYELLRLW----EQREGKNAtvGTLLEALRKLGRRDAAEK 81
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 90-121 8.06e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 33.80  E-value: 8.06e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 767936479   90 GNTALHLAAKH-GHSPAVQVLLAQWQDINEMNE 121
Cdd:pfam00023   2 GNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
PHA02736 PHA02736
Viral ankyrin protein; Provisional
 158-212 8.49e-03

Viral ankyrin protein; Provisional


Pssm-ID: 165103 [Multi-domain]  Cd Length: 154  Bit Score: 36.78  E-value: 8.49e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767936479 158 SPLHLVVINNHITVVNSLLSA-QHDIDILNQKQQTPLHVAADRGNVELVETLLKAG 212
Cdd:PHA02736  94 TPLHIAVYTQNYELATWLCNQpGVNMEILNYAFKTPYYVACERHDAKMMNILRAKG 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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