NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|768032528|ref|XP_011543841|]
View 

phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform X1 [Homo sapiens]

Protein Classification

glycosyltransferase family protein( domain architecture ID 56)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Glycosyltransferase_GTB-type super family cl10013
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 2-201 8.53e-114

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


The actual alignment was detected with superfamily member cd03796:

Pssm-ID: 471961 [Multi-domain]  Cd Length: 398  Bit Score: 331.90  E-value: 8.53e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528   2 KLSLREGIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLVQGHIFLNTSLTE 81
Cdd:cd03796  201 RLVYRKGIDLLVGIIPRICKKHPNVRFIIGGDGPKRIELEEMREKYQLQDRVELLGAVPHEEVRDVLVQGHIFLNTSLTE 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528  82 AFCMAIVEAASCGLQVVSTRVGGIPEVLPENLIILCEPSVKSLCEGLEKAIFQLKSGTlPAPENIHNIVKTFYTWRNVAE 161
Cdd:cd03796  281 AFCIAIVEAASCGLLVVSTRVGGIPEVLPPDMILLAEPDPEDIVRKLEEAISILRTGK-HDPWSFHNRVKKMYSWEDVAR 359

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 768032528 162 RTEKVYDRVSVEAVLPMDKRLdRLISHCGPVTGYIFALLA 201
Cdd:cd03796  360 RTEKVYDRILSTPNRPFLERL-KRYYNCGPIAGKIFCLLA 398
 
Name Accession Description Interval E-value
GT4_PIG-A-like cd03796
phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This ...
 2-201 8.53e-114

phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Phosphatidylinositol glycan-class A (PIG-A), an X-linked gene in humans, is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate in glycosyl phosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is an important cellular structure that facilitates the attachment of many proteins to cell surfaces. Somatic mutations in PIG-A have been associated with Paroxysmal Nocturnal Hemoglobinuria (PNH), an acquired hematological disorder.


Pssm-ID: 340827 [Multi-domain]  Cd Length: 398  Bit Score: 331.90  E-value: 8.53e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528   2 KLSLREGIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLVQGHIFLNTSLTE 81
Cdd:cd03796  201 RLVYRKGIDLLVGIIPRICKKHPNVRFIIGGDGPKRIELEEMREKYQLQDRVELLGAVPHEEVRDVLVQGHIFLNTSLTE 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528  82 AFCMAIVEAASCGLQVVSTRVGGIPEVLPENLIILCEPSVKSLCEGLEKAIFQLKSGTlPAPENIHNIVKTFYTWRNVAE 161
Cdd:cd03796  281 AFCIAIVEAASCGLLVVSTRVGGIPEVLPPDMILLAEPDPEDIVRKLEEAISILRTGK-HDPWSFHNRVKKMYSWEDVAR 359

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 768032528 162 RTEKVYDRVSVEAVLPMDKRLdRLISHCGPVTGYIFALLA 201
Cdd:cd03796  360 RTEKVYDRILSTPNRPFLERL-KRYYNCGPIAGKIFCLLA 398
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
6-132 4.14e-22

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 88.72  E-value: 4.14e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528    6 REGIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVREryqLHDRVRLLGALEhkDVRNVLVQGHIFLNTSLTEAFCM 85
Cdd:pfam13692  14 VKGVDYLLEAVPLLRKRDNDVRLVIVGDGPEEELEELAAG---LEDRVIFTGFVE--DLAELLAAADVFVLPSLYEGFGL 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 768032528   86 AIVEAASCGLQVVSTRVGGIPEVLPENLIILCEP-SVKSLCEGLEKAI 132
Cdd:pfam13692  89 KLLEAMAAGLPVVATDVGGIPELVDGENGLLVPPgDPEALAEAILRLL 136
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 72-170 5.45e-15

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 69.25  E-value: 5.45e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528  72 HIFLNTSLTEAFCMAIVEAASCGLQVVSTRVGGIPEVLPENLI-ILCEP-SVKSLCEGLEKAifqLKSGTLPA--PENIH 147
Cdd:COG0438   22 DVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETgLLVPPgDPEALAEAILRL---LEDPELRRrlGEAAR 98

                         90       100
                 ....*....|....*....|...
gi 768032528 148 NIVKTFYTWRNVAERTEKVYDRV 170
Cdd:COG0438   99 ERAEERFSWEAIAERLLALYEEL 121
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
81-166 2.96e-05

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 44.40  E-value: 2.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528  81 EAFCMAIVEAASCGLQVVSTRVGGIPEVLPENLI--ILCEP-SVKSLCEGLEKAIfqLKSGTLPAPENIHNIVKTFYTWR 157
Cdd:PRK15484 288 EAFCMVAVEAMAAGKPVLASTKGGITEFVLEGITgyHLAEPmTSDSIISDINRTL--ADPELTQIAEQAKDFVFSKYSWE 365


                 ....*....
gi 768032528 158 NVAERTEKV 166
Cdd:PRK15484 366 GVTQRFEEQ 374
 
Name Accession Description Interval E-value
GT4_PIG-A-like cd03796
phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This ...
 2-201 8.53e-114

phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Phosphatidylinositol glycan-class A (PIG-A), an X-linked gene in humans, is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate in glycosyl phosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is an important cellular structure that facilitates the attachment of many proteins to cell surfaces. Somatic mutations in PIG-A have been associated with Paroxysmal Nocturnal Hemoglobinuria (PNH), an acquired hematological disorder.


Pssm-ID: 340827 [Multi-domain]  Cd Length: 398  Bit Score: 331.90  E-value: 8.53e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528   2 KLSLREGIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLVQGHIFLNTSLTE 81
Cdd:cd03796  201 RLVYRKGIDLLVGIIPRICKKHPNVRFIIGGDGPKRIELEEMREKYQLQDRVELLGAVPHEEVRDVLVQGHIFLNTSLTE 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528  82 AFCMAIVEAASCGLQVVSTRVGGIPEVLPENLIILCEPSVKSLCEGLEKAIFQLKSGTlPAPENIHNIVKTFYTWRNVAE 161
Cdd:cd03796  281 AFCIAIVEAASCGLLVVSTRVGGIPEVLPPDMILLAEPDPEDIVRKLEEAISILRTGK-HDPWSFHNRVKKMYSWEDVAR 359

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 768032528 162 RTEKVYDRVSVEAVLPMDKRLdRLISHCGPVTGYIFALLA 201
Cdd:cd03796  360 RTEKVYDRILSTPNRPFLERL-KRYYNCGPIAGKIFCLLA 398
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 3-167 3.39e-25

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 101.85  E-value: 3.39e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528   3 LSLREGIDLLSGIIPELCQKYPDLNF-IIGGEGPKRiilEEVRER-YQLHDRVRLLGALEHKDVRNVLVQGHIFLNTSLT 80
Cdd:cd03801  201 LSPRKGVDLLLEALAKLLRRGPDVRLvIVGGDGPLR---AELEELeLGLGDRVRFLGFVPDEELPALYAAADVFVLPSRY 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528  81 EAFCMAIVEAASCGLQVVSTRVGGIPEVLP--ENLIILCEPSVKSLCEGLEKAifqLKSGTLPAP--ENIHNIVKTFYTW 156
Cdd:cd03801  278 EGFGLVVLEAMAAGLPVVATDVGGLPEVVEdgEGGLVVPPDDVEALADALLRL---LADPELRARlgRAARERVAERFSW 354

                        170
                 ....*....|.
gi 768032528 157 RNVAERTEKVY 167
Cdd:cd03801  355 ERVAERLLDLY 365
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
6-132 4.14e-22

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 88.72  E-value: 4.14e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528    6 REGIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVREryqLHDRVRLLGALEhkDVRNVLVQGHIFLNTSLTEAFCM 85
Cdd:pfam13692  14 VKGVDYLLEAVPLLRKRDNDVRLVIVGDGPEEELEELAAG---LEDRVIFTGFVE--DLAELLAAADVFVLPSLYEGFGL 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 768032528   86 AIVEAASCGLQVVSTRVGGIPEVLPENLIILCEP-SVKSLCEGLEKAI 132
Cdd:pfam13692  89 KLLEAMAAGLPVVATDVGGIPELVDGENGLLVPPgDPEALAEAILRLL 136
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 3-132 6.37e-21

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 86.17  E-value: 6.37e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528    3 LSLREGIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLVQGHIFLNTSLTEA 82
Cdd:pfam00534  11 LEPEKGLDLLIKAFALLKEKNPNLKLVIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIADVFVLPSRYEG 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 768032528   83 FCMAIVEAASCGLQVVSTRVGGIPEVLPENLI-ILCEP-SVKSLCEGLEKAI 132
Cdd:pfam00534  91 FGIVLLEAMACGLPVIASDVGGPPEVVKDGETgFLVKPnNAEALAEAIDKLL 142
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 6-170 2.15e-20

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 88.98  E-value: 2.15e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528   6 REGIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLVQGHIFLNTSLTEAFCM 85
Cdd:cd03798  212 RKGIDLLLEAFARLAKARPDVVLLIVGDGPLREALRALAEDLGLGDRVTFTGRLPHEQVPAYYRACDVFVLPSRHEGFGL 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528  86 AIVEAASCGLQVVSTRVGGIPEVL-PENLIILCEP-SVKSLCEGLEKAIfqLKSGTLPAPENIHNIVKTFYTWRNVAERT 163
Cdd:cd03798  292 VLLEAMACGLPVVATDVGGIPEVVgDPETGLLVPPgDADALAAALRRAL--AEPYLRELGEAARARVAERFSWVKAADRI 369


                 ....*..
gi 768032528 164 EKVYDRV 170
Cdd:cd03798  370 AAAYRDV 376
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 19-132 3.58e-18

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 82.36  E-value: 3.58e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528  19 LCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGalEHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVV 98
Cdd:cd03807  215 LVETHPDLRLLLVGRGPERPNLERLLLELGLEDRVHLLG--ERSDVPALLPAMDIFVLSSRTEGFPNALLEAMACGLPVV 292

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 768032528  99 STRVGGIPEVLPENLIILCEP-SVKSLCEGLEKAI 132
Cdd:cd03807  293 ATDVGGAAELVDDGTGFLVPAgDPQALADAIRALL 327
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 3-112 9.16e-18

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 79.76  E-value: 9.16e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528   3 LSLREGIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLVQG-HIFLNTSLTE 81
Cdd:cd01635  119 LVPEKGIDLLLEALALLKARLPDLVLVLVGGGGEREEEEALAAALGLLERVVIIGGLVDDEVLELLLAAaDVFVLPSRSE 198

                         90       100       110
                 ....*....|....*....|....*....|.
gi 768032528  82 AFCMAIVEAASCGLQVVSTRVGGIPEVLPEN 112
Cdd:cd01635  199 GFGLVLLEAMAAGKPVIATDVGGIPEFVVDG 229
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 3-136 2.28e-16

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 77.40  E-value: 2.28e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528   3 LSLREGIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGalEHKDVRNVLVQGHIFLNTSLTEA 82
Cdd:cd03811  197 LDPQKGHDLLIEAFAKLRKKYPDVKLVILGDGPLREELEKLAKELGLAERVIFLG--FQSNPYPYLKKADLFVLSSRYEG 274

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 768032528  83 FCMAIVEAASCGLQVVSTRVGGIPEVLPENL-IILCEPSVKSLCEGLEKAIFQLK 136
Cdd:cd03811  275 FPNVLLEAMALGTPVVSTDCPGPREILDDGEnGLLVPDGDAAALAGILAALLQKK 329
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 72-170 5.45e-15

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 69.25  E-value: 5.45e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528  72 HIFLNTSLTEAFCMAIVEAASCGLQVVSTRVGGIPEVLPENLI-ILCEP-SVKSLCEGLEKAifqLKSGTLPA--PENIH 147
Cdd:COG0438   22 DVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETgLLVPPgDPEALAEAILRL---LEDPELRRrlGEAAR 98

                         90       100
                 ....*....|....*....|...
gi 768032528 148 NIVKTFYTWRNVAERTEKVYDRV 170
Cdd:COG0438   99 ERAEERFSWEAIAERLLALYEEL 121
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 3-132 3.00e-14

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 71.09  E-value: 3.00e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528   3 LSLREGIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGalEHKDVRNVLVQGHIFLNTSLTEA 82
Cdd:cd03808  198 LLKDKGIDELIEAAKILKKKGPNVRFLLVGDGELENPSEILIEKLGLEGRIEFLG--FRSDVPELLAESDVFVLPSYREG 275

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 768032528  83 FCMAIVEAASCGLQVVSTRVGGIPE-VLPENLIILCEP-SVKSLCEGLEKAI 132
Cdd:cd03808  276 LPRSLLEAMAAGRPVITTDVPGCRElVIDGVNGFLVPPgDVEALADAIEKLI 327
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 8-99 4.91e-14

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 70.73  E-value: 4.91e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528   8 GIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGALehKDVRNVLVQGHIFLNTSLTEAFCMAI 87
Cdd:cd03820  195 GFDLLIEAWALIAKKHPDWKLRIYGDGPEREELEKLIDKLGLEDRVKLLGPT--KNIAEEYANSSIFVLSSRYEGFPMVL 272

                         90
                 ....*....|..
gi 768032528  88 VEAASCGLQVVS 99
Cdd:cd03820  273 LEAMAYGLPIIS 284
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 8-119 1.17e-13

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 69.31  E-value: 1.17e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528   8 GIDLLSGIIPELcQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGAleHKDVRNVLVQGHIFLNTSLTEAFCMAI 87
Cdd:cd03819  196 GWLLLVDAAAEL-KDEPDFRLLVAGDGPERDEIRRLVERLGLRDRVTFTGF--REDVPAALAASDVVVLPSLHEEFGRVA 272

                         90       100       110
                 ....*....|....*....|....*....|..
gi 768032528  88 VEAASCGLQVVSTRVGGIPEVLPENLIILCEP 119
Cdd:cd03819  273 LEAMACGTPVVATDVGGAREIVVHGRTGLLVP 304
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
 2-113 1.37e-13

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 69.40  E-value: 1.37e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528   2 KLSLREGIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLVQGHIFLNTSLT- 80
Cdd:cd03799  182 RLTEKKGLEYAIEAVAKLAQKYPNIEYQIIGDGDLKEQLQQLIQELNIGDCVKLLGWKPQEEIIEILDEADIFIAPSVTa 261

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 768032528  81 -----EAFCMAIVEAASCGLQVVSTRVGGIPEVLPENL 113
Cdd:cd03799  262 adgdqDGPPNTLKEAMAMGLPVISTEHGGIPELVEDGV 299
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 32-112 1.90e-13

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 68.92  E-value: 1.90e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528  32 GEGPKRIILEEVRERYQLHDRVRLLGALEHkdVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVSTRVGGIPEVLPE 111
Cdd:cd04962  233 GDGPERVPAEELARELGVEDRVLFLGKQDD--VEELLSIADLFLLPSEKESFGLAALEAMACGVPVVSSNAGGIPEVVKH 310


                 .
gi 768032528 112 N 112
Cdd:cd04962  311 G 311
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 6-164 1.97e-13

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 69.19  E-value: 1.97e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528   6 REGIDLL---SGIIPELCQkypDLNFIIGGeGPKRIILEEVRE-------RYQLHDRVRLLGALEHKDVRNVLVQGHIFL 75
Cdd:cd03800  232 RKGIDTLvraFAQLPELRE---LANLVLVG-GPSDDPLSMDREelaelaeELGLIDRVRFPGRVSRDDLPELYRAADVFV 307

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528  76 NTSLTEAFCMAIVEAASCGLQVVSTRVGGIPE-VLPENLIILCEP-SVKSLCEGLEKaIFQLKSGTLPAPENIHNIVKTF 153
Cdd:cd03800  308 VPSLYEPFGLTAIEAMACGTPVVATAVGGLQDiVRDGRTGLLVDPhDPEALAAALRR-LLDDPALWQRLSRAGLERARAH 386

                        170
                 ....*....|.
gi 768032528 154 YTWRNVAERTE 164
Cdd:cd03800  387 YTWESVADQLL 397
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
 16-115 3.46e-13

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 68.24  E-value: 3.46e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528  16 IPELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGAleHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGL 95
Cdd:cd04951  210 ISELILSKNDFKLLIAGDGPLRNELERLICNLNLVDRVILLGQ--ISNISEYYNAADLFVLSSEWEGFGLVVAEAMACER 287

                         90       100
                 ....*....|....*....|.
gi 768032528  96 QVVSTRVGGIPEVL-PENLII 115
Cdd:cd04951  288 PVVATDAGGVAEVVgDHNYVV 308
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 9-170 1.16e-12

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 66.53  E-value: 1.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528   9 IDLLSGIIPELCQKyPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLVQGHIFLNTSLTEAFCMAIV 88
Cdd:cd03817  216 IDFLLRAFAELKKE-PNIKLVIVGDGPEREELKELARELGLADKVIFTGFVPREELPEYYKAADLFVFASTTETQGLVYL 294

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528  89 EAASCGLQVVSTRVGGIPEVLpENLI--ILCEPSVKSLCEGLEKAIFQLKSGTLPApENIHNIVKTFytwrNVAERTEKV 166
Cdd:cd03817  295 EAMAAGLPVVAAKDPAASELV-EDGEngFLFEPNDETLAEKLLHLRENLELLRKLS-KNAEISAREF----AFAKSVEKL 368


                 ....
gi 768032528 167 YDRV 170
Cdd:cd03817  369 YEEV 372
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
 6-107 1.82e-12

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 65.94  E-value: 1.82e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528   6 REGIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVRERYqlhDRVRLLGALEHKDVRNVLVQGHIFLNTSLT----- 80
Cdd:cd05844  201 KKGCDVLIEAFRRLAARHPTARLVIAGDGPLRPALQALAAAL---GRVRFLGALPHAEVQDWMRRAEIFCLPSVTaasgd 277

                         90       100
                 ....*....|....*....|....*...
gi 768032528  81 -EAFCMAIVEAASCGLQVVSTRVGGIPE 107
Cdd:cd05844  278 sEGLGIVLLEAAACGVPVVSSRHGGIPE 305
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 6-164 2.07e-12

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 65.85  E-value: 2.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528   6 REGIDLLSGIIPELCQKYPDLNFIIGGEGPKriiLEEVRERYQ----LHDRVRLLGALEHKDVRNVLVQGHIFLNTSLTE 81
Cdd:cd03821  216 KKGLDLLIRAARKLAEQGRDWHLVIAGPDDG---AYPAFLQLQsslgLGDRVTFTGPLYGEAKWALYASADLFVLPSYSE 292

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528  82 AFCMAIVEAASCGLQVVSTRVGGIPEVLPENLIILCEPSVKSLCEGLEKAIfQLKSGTLPAPENIHNIVKT--FYTWRNV 159
Cdd:cd03821  293 NFGNVVAEALACGLPVVITDKCGLSELVEAGCGVVVDPNVSSLAEALAEAL-RDPADRKRLGEMARRARQVeeNFSWEAV 371


                 ....*
gi 768032528 160 AERTE 164
Cdd:cd03821  372 AGQLG 376
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 22-165 8.07e-12

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 64.31  E-value: 8.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528  22 KYPDLN-FIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVST 100
Cdd:cd03809  220 QGGDLKlVIVGGKGWEDEELLDLVKKLGLGGRVRFLGYVSDEDLPALYRGARAFVFPSLYEGFGLPVLEAMACGTPVIAS 299

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 768032528 101 RVGGIPEVLPENlIILCEP-SVKSLCEGLEKAIFQlKSGTLPAPENIHNIVKTFyTWRNVAERTEK 165
Cdd:cd03809  300 NISVLPEVAGDA-ALYFDPlDPESIADAILRLLED-PSLREELIRKGLERAKKF-SWEKTAEKTLE 362
GT4_AmsK-like cd04946
amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most ...
 9-132 5.30e-10

amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose to a lipid-linked amylovoran-subunit precursor. The members of this family are found mainly in bacteria and Archaea.


Pssm-ID: 340854 [Multi-domain]  Cd Length: 401  Bit Score: 59.01  E-value: 5.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528   9 IDLLSGIIPELCQKYPDLNFI---IGGeGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLVQG--HIFLNTSLTEAF 83
Cdd:cd04946  239 IDLIIETLNSLCVAHPSICISwthIGG-GPLKERLEKLAENKLENVKVNFTGEVSNKEVKQLYKENdvDVFVNVSESEGI 317

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 768032528  84 CMAIVEAASCGLQVVSTRVGGIPEVLpEN----LIILCEPSVKSLCEGLEKAI 132
Cdd:cd04946  318 PVSIMEAISFGIPVIATNVGGTREIV-ENetngLLLDKDPTPNEIVSSIMKFY 369
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 3-111 1.05e-09

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 58.07  E-value: 1.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528   3 LSLREGIDLLSGIIPELCQKYPdLNFIIGGEGPKRiilEEVRERYqlhDRVRLLGALEHKDVRNVLVQGHIFLNTSLTEA 82
Cdd:cd03814  207 LAPEKNLEALLDADLPLAASPP-VRLVVVGDGPAR---AELEARG---PDVIFTGFLTGEELARAYASADVFVFPSRTET 279

                         90       100
                 ....*....|....*....|....*....
gi 768032528  83 FCMAIVEAASCGLQVVSTRVGGIPEVLPE 111
Cdd:cd03814  280 FGLVVLEAMASGLPVVAADAGGPRDIVRP 308
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 8-167 4.37e-08

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 53.10  E-value: 4.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528   8 GIDLLSgiipELCQKYPDLN--FIIGGEGPKRIIleevrERYQLHDRVRLLGALEHKDVRNVLVQGHIFLNTSL-TEAFC 84
Cdd:cd03823  205 GIDLLV----EAFKRLPREDieLVIAGHGPLSDE-----RQIEGGRRIAFLGRVPTDDIKDFYEKIDVLVVPSIwPEPFG 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528  85 MAIVEAASCGLQVVSTRVGGIPE-VLPENLIILCEPSVKslcEGLEKAIFQL-KSGTLPAPENIHNIVKTFYTWRnvAER 162
Cdd:cd03823  276 LVVREAIAAGLPVIASDLGGIAElIQPGVNGLLFAPGDA---EDLAAAMRRLlTDPALLERLRAGAEPPRSTESQ--AEE 350


                 ....*
gi 768032528 163 TEKVY 167
Cdd:cd03823  351 YLKLY 355
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 22-104 5.05e-08

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 52.66  E-value: 5.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528  22 KYPDLNFIIGGEGPKRIILEEVRErYQLHDRVRLLGALEHKDVRNVLVQGHIFLNTSL--TEAFCMAIVEAASCGLQVVS 99
Cdd:cd03795  214 QYLNYPIVIGGEGPLKPDLEAQIE-LNLLDNVKFLGRVDDEEKVIYLHLCDVFVFPSVlrSEAFGIVLLEAMMCGKPVIS 292


                 ....*
gi 768032528 100 TRVGG 104
Cdd:cd03795  293 TNIGT 297
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
 2-102 1.91e-07

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 51.15  E-value: 1.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528   2 KLSLREGIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGAleHKDVRNVLVQGHIFLNTSLTE 81
Cdd:cd04949  168 RLAPEKQLDHLIEAVAKAVKKVPEITLDIYGYGEEREKLKKLIEELHLEDNVFLKGY--HSNLDQEYQDAYLSLLTSQME 245

                         90       100
                 ....*....|....*....|.
gi 768032528  82 AFCMAIVEAASCGLQVVSTRV 102
Cdd:cd04949  246 GFGLTLMEAIGHGLPVVSYDV 266
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 24-109 3.53e-07

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 50.41  E-value: 3.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528  24 PDLNF-IIGGEGPKRIILEEVRERYQ---LHDRVRLLGaleHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVS 99
Cdd:cd03813  323 PDAEGwLIGPEDEDPEYAQECKRLVAslgLENKVKFLG---FQNIKEYYPKLGLLVLTSISEGQPLVILEAMASGVPVVA 399

                         90
                 ....*....|
gi 768032528 100 TRVGGIPEVL 109
Cdd:cd03813  400 TDVGSCRELI 409
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
81-166 2.96e-05

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 44.40  E-value: 2.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528  81 EAFCMAIVEAASCGLQVVSTRVGGIPEVLPENLI--ILCEP-SVKSLCEGLEKAIfqLKSGTLPAPENIHNIVKTFYTWR 157
Cdd:PRK15484 288 EAFCMVAVEAMAAGKPVLASTKGGITEFVLEGITgyHLAEPmTSDSIISDINRTL--ADPELTQIAEQAKDFVFSKYSWE 365


                 ....*....
gi 768032528 158 NVAERTEKV 166
Cdd:PRK15484 366 GVTQRFEEQ 374
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
 18-111 9.57e-05

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 43.16  E-value: 9.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528  18 ELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHdrvrLLGALEHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQV 97
Cdd:PLN02871 283 RVMERLPGARLAFVGDGPYREELEKMFAGTPTV----FTGMLQGDELSQAYASGDVFVMPSESETLGFVVLEAMASGVPV 358

                         90
                 ....*....|....
gi 768032528  98 VSTRVGGIPEVLPE 111
Cdd:PLN02871 359 VAARAGGIPDIIPP 372
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 29-129 1.40e-04

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 42.32  E-value: 1.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528  29 IIGGEGPKRIILE-EVRERYQLHDRVRLlgalehkdvRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVSTRVGGIPE 107
Cdd:cd03825  230 VFGKNDPQIVILPfDIISLGYIDDDEQL---------VDIYSAADLFVHPSLADNLPNTLLEAMACGTPVVAFDTGGSPE 300

                         90       100
                 ....*....|....*....|....
gi 768032528 108 VL--PENLIILCEPSVKSLCEGLE 129
Cdd:cd03825  301 IVqhGVTGYLVPPGDVQALAEAIE 324
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
 51-170 1.50e-04

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 42.27  E-value: 1.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528  51 DRVRLLGALEHKDVRNVLVQGHIFLNTSL-TEAFCMAIVEAASCGLQVVSTRVGGIPEVLPENLI-ILCEPSvkslcEGL 128
Cdd:cd03802  220 PRIEFIGEVGHDEKQELLGGARALLFPINwDEPFGLVMIEAMACGTPVIAYRRGGLPEVIQHGETgFLVDSV-----EEM 294

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 768032528 129 EKAIfqLKSGTLPaPENIHNIVKTFYTWRNVAERTEKVYDRV 170
Cdd:cd03802  295 AEAI--ANIDRID-RAACRRYAEDRFSAARMADRYEALYRKV 333
PRK15179 PRK15179
Vi polysaccharide biosynthesis protein TviE; Provisional
 18-113 2.24e-04

Vi polysaccharide biosynthesis protein TviE; Provisional


Pssm-ID: 185101 [Multi-domain]  Cd Length: 694  Bit Score: 42.33  E-value: 2.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528  18 ELCQKY----PDLNFIIGGEGPkriILEEVRE---RYQLHDRVRLLGALEHkdVRNVLVQGHIFLNTSLTEAFCMAIVEA 90
Cdd:PRK15179 537 EAAQRFaashPKVRFIMVGGGP---LLESVREfaqRLGMGERILFTGLSRR--VGYWLTQFNAFLLLSRFEGLPNVLIEA 611

                         90       100
                 ....*....|....*....|...
gi 768032528  91 ASCGLQVVSTRVGGIPEVLPENL 113
Cdd:PRK15179 612 QFSGVPVVTTLAGGAGEAVQEGV 634
GT4_CapH-like cd03812
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ...
 15-98 1.12e-03

capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).


Pssm-ID: 340840 [Multi-domain]  Cd Length: 357  Bit Score: 39.58  E-value: 1.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528  15 IIPELCQKYPDLNFIIGGEGPKRI-ILEEVRERyQLHDRVRLLGalEHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASC 93
Cdd:cd03812  212 IFEELKKKNPNVKLVLVGEGELKEkIKEKVKEL-GLEDKVIFLG--FRNDVSEILSAMDVFLFPSLYEGLPLVAVEAQAS 288


                 ....*
gi 768032528  94 GLQVV 98
Cdd:cd03812  289 GLPCL 293
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 7-164 1.62e-03

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 39.25  E-value: 1.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528   7 EGIDLLSGIIPELcQKYPDLNFIIGGEGPKRIILEEVRERYQLhDRVRLLGALEHKDVRNVLVQGHIFLNTSLTEAFCMA 86
Cdd:cd03794  230 QGLETLLEAAERL-KRRPDIRFLFVGDGDEKERLKELAKARGL-DNVTFLGRVPKEEVPELLSAADVGLVPLKDNPANRG 307

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528  87 IV-----EAASCGLQVVSTRVGGIPE-VLPENLIILCEP-SVKSLCEGLEKAIFQLKSGTLPApENIHNIVKTFYTWRNV 159
Cdd:cd03794  308 SSpsklfEYMAAGKPILASDDGGSDLaVEINGCGLVVEPgDPEALADAILELLDDPELRRAMG-ENGRELAEEKFSREKL 386


                 ....*
gi 768032528 160 AERTE 164
Cdd:cd03794  387 ADRLL 391
GT4_trehalose_phosphorylase cd03792
trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly ...
 18-106 4.65e-03

trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose, and the subsequent synthesis of trehalose. This family is most closely related to the GT4 family of glycosyltransferases.


Pssm-ID: 340823 [Multi-domain]  Cd Length: 378  Bit Score: 37.69  E-value: 4.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528  18 ELCQKYPDLNFIIGGEGPKR-----IILEEVRERYQLHDRVRLLGALEHKDVRNVLVQG-HIFLNTSLTEAFCMAIVEAA 91
Cdd:cd03792  221 LFKRRAEEPQLVICGHGAVDdpegsVVYEEVMEYAGDDHDIHVLRLPPSDQEINALQRAaTVVLQLSTREGFGLTVSEAL 300

                         90
                 ....*....|....*
gi 768032528  92 SCGLQVVSTRVGGIP 106
Cdd:cd03792  301 WKGKPVIATPAGGIP 315
PRK15490 PRK15490
Vi polysaccharide biosynthesis glycosyltransferase TviE;
21-113 7.04e-03

Vi polysaccharide biosynthesis glycosyltransferase TviE;


Pssm-ID: 185387 [Multi-domain]  Cd Length: 578  Bit Score: 37.37  E-value: 7.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768032528  21 QKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGAleHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVST 100
Cdd:PRK15490 425 QHHPATRFVLVGDGDLRAEAQKRAEQLGILERILFVGA--SRDVGYWLQKMNVFILFSRYEGLPNVLIEAQMVGVPVIST 502

                         90
                 ....*....|...
gi 768032528 101 RVGGIPEVLPENL 113
Cdd:PRK15490 503 PAGGSAECFIEGV 515
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH