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Conserved domains on  [gi|847135186|ref|XP_012820104|]
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zinc finger E-box-binding homeobox 1 isoform X1 [Xenopus tropicalis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
937-962 2.73e-07

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 47.75  E-value: 2.73e-07
                           10        20
                   ....*....|....*....|....*.
gi 847135186   937 HLIEHMRLHSGEKPYQCDKCGKRFSH 962
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
257-280 3.42e-07

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 47.37  E-value: 3.42e-07
                           10        20
                   ....*....|....*....|....
gi 847135186   257 HLKEHLRIHSGEKPYECPNCKKRF 280
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 243-265 1.67e-06

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 45.37  E-value: 1.67e-06
                           10        20
                   ....*....|....*....|...
gi 847135186   243 FKCPECGKAFKYKHHLKEHLRIH 265
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
GET2 super family cl07347
GET complex subunit GET2; This family corresponds to the GET complex subunit GET2. The GET ...
 61-173 7.88e-05

GET complex subunit GET2; This family corresponds to the GET complex subunit GET2. The GET complex is involved in the retrieval of ER resident proteins from the Golgi. It forms a complex with GET1 and constitutes the ER membrane receptor for GET3. It facilitates the release of tail- anchored (TA) proteins from GET3 and mediates the subsequent entry into the ER membrane.


The actual alignment was detected with superfamily member pfam08690:

Pssm-ID: 400847  Cd Length: 308  Bit Score: 45.86  E-value: 7.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847135186    61 DLPTDQTVLPEGSESAKGSGKTCWEDEEGADCSDEILGPEAEADELGCTVKDEECDsdleneqNQDPNVEEFLQQSDTAv 140
Cdd:pfam08690   45 DEPAAPSTTPASTTASSSPSADEHDDPEIVDISEIASQPKKTASVPKKPPSSEESD-------PENPQLDQMFKQLLGQ- 116

                           90       100       110
                   ....*....|....*....|....*....|...
gi 847135186   141 iypeapeddQRQGTPEAVGQDENGTPDAFSQLL 173
Cdd:pfam08690  117 ---------QQQGGGENGQPAGSSTPDLFSQMM 140
zf-H2C2_2 pfam13465
Zinc-finger double domain;
909-934 1.45e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.45e-04
                           10        20
                   ....*....|....*....|....*.
gi 847135186   909 SLLRHKYEHTGKRPHECGICAKAFKH 934
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
Homeodomain super family cl47488
Homeodomain;
580-633 1.65e-04

Homeodomain;


The actual alignment was detected with superfamily member pfam00046:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 40.56  E-value: 1.65e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 847135186   580 NLTPSQpplknlLSLLKAYYALNAQPSSEELSKIADSVNLPLDVVKDWFekmQN 633
Cdd:pfam00046    6 TFTPEQ------LEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWF---QN 50
zf-H2C2_2 pfam13465
Zinc-finger double domain;
218-254 1.73e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.73e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 847135186   218 LDRHMTSHKsgkdqrhvtqsgGNRKFKCPECGKAFKY 254
Cdd:pfam13465    2 LKRHMRTHT------------GEKPYKCPECGKSFKS 26
ZnF_C2H2 smart00355
zinc finger;
203-225 7.36e-03

zinc finger;


:

Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.13  E-value: 7.36e-03
                            10        20
                    ....*....|....*....|...
gi 847135186    203 FSCSMCSYTFAYRTQLDRHMTSH 225
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
937-962 2.73e-07

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 47.75  E-value: 2.73e-07
                           10        20
                   ....*....|....*....|....*.
gi 847135186   937 HLIEHMRLHSGEKPYQCDKCGKRFSH 962
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
257-280 3.42e-07

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 47.37  E-value: 3.42e-07
                           10        20
                   ....*....|....*....|....
gi 847135186   257 HLKEHLRIHSGEKPYECPNCKKRF 280
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 243-265 1.67e-06

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 45.37  E-value: 1.67e-06
                           10        20
                   ....*....|....*....|...
gi 847135186   243 FKCPECGKAFKYKHHLKEHLRIH 265
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
GET2 pfam08690
GET complex subunit GET2; This family corresponds to the GET complex subunit GET2. The GET ...
 61-173 7.88e-05

GET complex subunit GET2; This family corresponds to the GET complex subunit GET2. The GET complex is involved in the retrieval of ER resident proteins from the Golgi. It forms a complex with GET1 and constitutes the ER membrane receptor for GET3. It facilitates the release of tail- anchored (TA) proteins from GET3 and mediates the subsequent entry into the ER membrane.


Pssm-ID: 400847  Cd Length: 308  Bit Score: 45.86  E-value: 7.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847135186    61 DLPTDQTVLPEGSESAKGSGKTCWEDEEGADCSDEILGPEAEADELGCTVKDEECDsdleneqNQDPNVEEFLQQSDTAv 140
Cdd:pfam08690   45 DEPAAPSTTPASTTASSSPSADEHDDPEIVDISEIASQPKKTASVPKKPPSSEESD-------PENPQLDQMFKQLLGQ- 116

                           90       100       110
                   ....*....|....*....|....*....|...
gi 847135186   141 iypeapeddQRQGTPEAVGQDENGTPDAFSQLL 173
Cdd:pfam08690  117 ---------QQQGGGENGQPAGSSTPDLFSQMM 140
zf-H2C2_2 pfam13465
Zinc-finger double domain;
909-934 1.45e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.45e-04
                           10        20
                   ....*....|....*....|....*.
gi 847135186   909 SLLRHKYEHTGKRPHECGICAKAFKH 934
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
Homeodomain pfam00046
Homeodomain;
580-633 1.65e-04

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 40.56  E-value: 1.65e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 847135186   580 NLTPSQpplknlLSLLKAYYALNAQPSSEELSKIADSVNLPLDVVKDWFekmQN 633
Cdd:pfam00046    6 TFTPEQ------LEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWF---QN 50
ZnF_C2H2 smart00355
zinc finger;
243-265 1.72e-04

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 39.76  E-value: 1.72e-04
                            10        20
                    ....*....|....*....|...
gi 847135186    243 FKCPECGKAFKYKHHLKEHLRIH 265
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
218-254 1.73e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.73e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 847135186   218 LDRHMTSHKsgkdqrhvtqsgGNRKFKCPECGKAFKY 254
Cdd:pfam13465    2 LKRHMRTHT------------GEKPYKCPECGKSFKS 26
ZnF_C2H2 smart00355
zinc finger;
923-945 6.41e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.13  E-value: 6.41e-03
                            10        20
                    ....*....|....*....|...
gi 847135186    923 HECGICAKAFKHKHHLIEHMRLH 945
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
ZnF_C2H2 smart00355
zinc finger;
203-225 7.36e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.13  E-value: 7.36e-03
                            10        20
                    ....*....|....*....|...
gi 847135186    203 FSCSMCSYTFAYRTQLDRHMTSH 225
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
937-962 2.73e-07

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 47.75  E-value: 2.73e-07
                           10        20
                   ....*....|....*....|....*.
gi 847135186   937 HLIEHMRLHSGEKPYQCDKCGKRFSH 962
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
257-280 3.42e-07

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 47.37  E-value: 3.42e-07
                           10        20
                   ....*....|....*....|....
gi 847135186   257 HLKEHLRIHSGEKPYECPNCKKRF 280
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 243-265 1.67e-06

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 45.37  E-value: 1.67e-06
                           10        20
                   ....*....|....*....|...
gi 847135186   243 FKCPECGKAFKYKHHLKEHLRIH 265
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
GET2 pfam08690
GET complex subunit GET2; This family corresponds to the GET complex subunit GET2. The GET ...
 61-173 7.88e-05

GET complex subunit GET2; This family corresponds to the GET complex subunit GET2. The GET complex is involved in the retrieval of ER resident proteins from the Golgi. It forms a complex with GET1 and constitutes the ER membrane receptor for GET3. It facilitates the release of tail- anchored (TA) proteins from GET3 and mediates the subsequent entry into the ER membrane.


Pssm-ID: 400847  Cd Length: 308  Bit Score: 45.86  E-value: 7.88e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 847135186    61 DLPTDQTVLPEGSESAKGSGKTCWEDEEGADCSDEILGPEAEADELGCTVKDEECDsdleneqNQDPNVEEFLQQSDTAv 140
Cdd:pfam08690   45 DEPAAPSTTPASTTASSSPSADEHDDPEIVDISEIASQPKKTASVPKKPPSSEESD-------PENPQLDQMFKQLLGQ- 116

                           90       100       110
                   ....*....|....*....|....*....|...
gi 847135186   141 iypeapeddQRQGTPEAVGQDENGTPDAFSQLL 173
Cdd:pfam08690  117 ---------QQQGGGENGQPAGSSTPDLFSQMM 140
zf-H2C2_2 pfam13465
Zinc-finger double domain;
909-934 1.45e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.45e-04
                           10        20
                   ....*....|....*....|....*.
gi 847135186   909 SLLRHKYEHTGKRPHECGICAKAFKH 934
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
Homeodomain pfam00046
Homeodomain;
580-633 1.65e-04

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 40.56  E-value: 1.65e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 847135186   580 NLTPSQpplknlLSLLKAYYALNAQPSSEELSKIADSVNLPLDVVKDWFekmQN 633
Cdd:pfam00046    6 TFTPEQ------LEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWF---QN 50
ZnF_C2H2 smart00355
zinc finger;
243-265 1.72e-04

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 39.76  E-value: 1.72e-04
                            10        20
                    ....*....|....*....|...
gi 847135186    243 FKCPECGKAFKYKHHLKEHLRIH 265
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 923-945 2.30e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.21  E-value: 2.30e-04
                           10        20
                   ....*....|....*....|...
gi 847135186   923 HECGICAKAFKHKHHLIEHMRLH 945
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 243-265 1.66e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 36.85  E-value: 1.66e-03
                           10        20
                   ....*....|....*....|...
gi 847135186   243 FKCPECGKAFKYKHHLKEHLRIH 265
Cdd:pfam13894    1 FKCPICGKSFSSKKSLKRHLKTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
218-254 1.73e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.73e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 847135186   218 LDRHMTSHKsgkdqrhvtqsgGNRKFKCPECGKAFKY 254
Cdd:pfam13465    2 LKRHMRTHT------------GEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 951-971 3.88e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 3.88e-03
                           10        20
                   ....*....|....*....|.
gi 847135186   951 YQCDKCGKRFSHSGSYSQHMN 971
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLR 21
ZnF_C2H2 smart00355
zinc finger;
923-945 6.41e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.13  E-value: 6.41e-03
                            10        20
                    ....*....|....*....|...
gi 847135186    923 HECGICAKAFKHKHHLIEHMRLH 945
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
ZnF_C2H2 smart00355
zinc finger;
203-225 7.36e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 35.13  E-value: 7.36e-03
                            10        20
                    ....*....|....*....|...
gi 847135186    203 FSCSMCSYTFAYRTQLDRHMTSH 225
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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