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Conserved domains on  [gi|861500000|ref|XP_012923056|]
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lipoma HMGIC fusion partner-like 2 protein [Heterocephalus glaber]

Protein Classification

LHFPL tetraspan protein( domain architecture ID 10563002)

LHFPL (lipoma HMGIC fusion partner-like) tetraspan protein similar to human LHFPL5 that may be a component of hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
L_HMGIC_fpl pfam10242
Lipoma HMGIC fusion partner-like protein; This is a group of proteins expressed from a series ...
9-203 1.66e-64

Lipoma HMGIC fusion partner-like protein; This is a group of proteins expressed from a series of genes referred to as Lipoma HMGIC fusion partner-like. The proteins carry four highly conserved transmembrane domains in this entry. In certain instances, eg in LHFPL5, mutations cause deafness in humans and hypospadias, and LHFPL1 is transcribed in six liver tumor cell lines.


:

Pssm-ID: 431166  Cd Length: 180  Bit Score: 197.94  E-value: 1.66e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861500000    9 RSMLWTLLSIVVAFAELIAFMSADWLIGKAksrgggaestaggaPEPPHPTLGIYARCIRNPGlqhvpRDTLCGPYAESF 88
Cdd:pfam10242   1 VGVLWALLTICFAVLSVVAFVQPYWLGGSV--------------SSPKAGSFGLYSRCKGMDQ-----MELTCGGYALDF 61
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861500000   89 GEIASGFWQATAIFLAVGILILCLVALVSVFTMCVQSIMKKSIFNVCGLLQGIAGLFLILGLILYPAGWGCQKAIDYCGH 168
Cdd:pfam10242  62 LAIPSSAWQAAMFFVGLGTFLLLSIACLSLFTCCRQSIISKSVFKICGWLQLVAGLCLMLGCLLYPLGWDSPEVRRLCGP 141
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 861500000  169 YASAYKPGDCSLGWAFYTAI----GGTVLTFICAVFSAQ 203
Cdd:pfam10242 142 ESGPYSLGLCSIGWAYYLAIigilDALLLTFLAFVLSLR 180
 
Name Accession Description Interval E-value
L_HMGIC_fpl pfam10242
Lipoma HMGIC fusion partner-like protein; This is a group of proteins expressed from a series ...
9-203 1.66e-64

Lipoma HMGIC fusion partner-like protein; This is a group of proteins expressed from a series of genes referred to as Lipoma HMGIC fusion partner-like. The proteins carry four highly conserved transmembrane domains in this entry. In certain instances, eg in LHFPL5, mutations cause deafness in humans and hypospadias, and LHFPL1 is transcribed in six liver tumor cell lines.


Pssm-ID: 431166  Cd Length: 180  Bit Score: 197.94  E-value: 1.66e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861500000    9 RSMLWTLLSIVVAFAELIAFMSADWLIGKAksrgggaestaggaPEPPHPTLGIYARCIRNPGlqhvpRDTLCGPYAESF 88
Cdd:pfam10242   1 VGVLWALLTICFAVLSVVAFVQPYWLGGSV--------------SSPKAGSFGLYSRCKGMDQ-----MELTCGGYALDF 61
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861500000   89 GEIASGFWQATAIFLAVGILILCLVALVSVFTMCVQSIMKKSIFNVCGLLQGIAGLFLILGLILYPAGWGCQKAIDYCGH 168
Cdd:pfam10242  62 LAIPSSAWQAAMFFVGLGTFLLLSIACLSLFTCCRQSIISKSVFKICGWLQLVAGLCLMLGCLLYPLGWDSPEVRRLCGP 141
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 861500000  169 YASAYKPGDCSLGWAFYTAI----GGTVLTFICAVFSAQ 203
Cdd:pfam10242 142 ESGPYSLGLCSIGWAYYLAIigilDALLLTFLAFVLSLR 180
 
Name Accession Description Interval E-value
L_HMGIC_fpl pfam10242
Lipoma HMGIC fusion partner-like protein; This is a group of proteins expressed from a series ...
9-203 1.66e-64

Lipoma HMGIC fusion partner-like protein; This is a group of proteins expressed from a series of genes referred to as Lipoma HMGIC fusion partner-like. The proteins carry four highly conserved transmembrane domains in this entry. In certain instances, eg in LHFPL5, mutations cause deafness in humans and hypospadias, and LHFPL1 is transcribed in six liver tumor cell lines.


Pssm-ID: 431166  Cd Length: 180  Bit Score: 197.94  E-value: 1.66e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861500000    9 RSMLWTLLSIVVAFAELIAFMSADWLIGKAksrgggaestaggaPEPPHPTLGIYARCIRNPGlqhvpRDTLCGPYAESF 88
Cdd:pfam10242   1 VGVLWALLTICFAVLSVVAFVQPYWLGGSV--------------SSPKAGSFGLYSRCKGMDQ-----MELTCGGYALDF 61
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 861500000   89 GEIASGFWQATAIFLAVGILILCLVALVSVFTMCVQSIMKKSIFNVCGLLQGIAGLFLILGLILYPAGWGCQKAIDYCGH 168
Cdd:pfam10242  62 LAIPSSAWQAAMFFVGLGTFLLLSIACLSLFTCCRQSIISKSVFKICGWLQLVAGLCLMLGCLLYPLGWDSPEVRRLCGP 141
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 861500000  169 YASAYKPGDCSLGWAFYTAI----GGTVLTFICAVFSAQ 203
Cdd:pfam10242 142 ESGPYSLGLCSIGWAYYLAIigilDALLLTFLAFVLSLR 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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