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Conserved domains on  [gi|928153611|ref|XP_013974533|]
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interferon regulatory factor 5 isoform X1 [Canis lupus familiaris]

Protein Classification

interferon regulatory factor( domain architecture ID 10457095)

interferon regulatory factor (IRF) is a transcriptional regulator that is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IRF-3 pfam10401
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 353-537 1.77e-92

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


:

Pssm-ID: 463076  Cd Length: 180  Bit Score: 282.22  E-value: 1.77e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928153611  353 LTDLEIKFQYRGRPPRALTISNPQGCRLFYsqlEPTQDQVELFGPVSLEQVRFPSPEDIPSDKQRFYTNQLLDVLDRGLI 432
Cdd:pfam10401   1 DTDLEITFFYRGRLVLELTVSSPEGCRLSY---GPPDPQVALYGPVALQQVRFPDPDGIPDERQREYTRRLLNVLERGLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928153611  433 LQLQGQDLYAIRLCQCKVFWSGPCASaHGSHPNPIQREVKTKLFSLEHFLNELILFQKGQTnTPPPFEIFFCFGEEWPDR 512
Cdd:pfam10401  78 LWVAGQGLYAKRLCQSRVFWSGPEAP-GGDKPNKLERDATVKLFDLAKFLRELILFQEGRG-RSPDYTITLCFGEEWPDD 155

                         170       180
                  ....*....|....*....|....*
gi 928153611  513 KPREKKLITVQVVPVAARLLLEMFS 537
Cdd:pfam10401 156 KPREKKLITVQVVPLFARQLLEMAS 180
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 102-207 4.24e-60

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


:

Pssm-ID: 459863  Cd Length: 106  Bit Score: 195.09  E-value: 4.24e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928153611  102 RLKPWLVAQVNSCQYPGLQWVNGERKFFCIPWRHATRHGPSQEGDNTIFKAWAKETGKYTEGVDEADPAKWKANLRCALN 181
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNQEEDAAIFKAWAVHTGKYREGVDKPDPATWKTNFRCALN 80

                          90       100
                  ....*....|....*....|....*.
gi 928153611  182 KSRDFRLIYDGPRDMPPQPYKIYEVC 207
Cdd:pfam00605  81 KLPDFEEVKDRSKDDGSDPYKVYRIL 106
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 257-414 9.39e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 9.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928153611  257 PSLSITEAVQPGPPMAPYSLPKEDVKWPPTLQPPVvlgPPAPDPSLLGPTPGNPAGfgELLPEVLPSLQPGPLAASLPPT 336
Cdd:PHA03247 2889 PAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQP---PPPPQPQPPPPPPPRPQP--PLAPTTDPAGAGEPSGAVPQPW 2963

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928153611  337 GEQLLPDLLISPHML---PLTDLEIKfqyrGRPPRALTISNPQGCRLFYSQLEPTQDQVElfGPVSLEQVRFPSPEDIPS 413
Cdd:PHA03247 2964 LGALVPGRVAVPRFRvpqPAPSREAP----ASSTPPLTGHSLSRVSSWASSLALHEETDP--PPVSLKQTLWPPDDTEDS 3037


                  .
gi 928153611  414 D 414
Cdd:PHA03247 3038 D 3038
 
Name Accession Description Interval E-value
IRF-3 pfam10401
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 353-537 1.77e-92

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


Pssm-ID: 463076  Cd Length: 180  Bit Score: 282.22  E-value: 1.77e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928153611  353 LTDLEIKFQYRGRPPRALTISNPQGCRLFYsqlEPTQDQVELFGPVSLEQVRFPSPEDIPSDKQRFYTNQLLDVLDRGLI 432
Cdd:pfam10401   1 DTDLEITFFYRGRLVLELTVSSPEGCRLSY---GPPDPQVALYGPVALQQVRFPDPDGIPDERQREYTRRLLNVLERGLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928153611  433 LQLQGQDLYAIRLCQCKVFWSGPCASaHGSHPNPIQREVKTKLFSLEHFLNELILFQKGQTnTPPPFEIFFCFGEEWPDR 512
Cdd:pfam10401  78 LWVAGQGLYAKRLCQSRVFWSGPEAP-GGDKPNKLERDATVKLFDLAKFLRELILFQEGRG-RSPDYTITLCFGEEWPDD 155

                         170       180
                  ....*....|....*....|....*
gi 928153611  513 KPREKKLITVQVVPVAARLLLEMFS 537
Cdd:pfam10401 156 KPREKKLITVQVVPLFARQLLEMAS 180
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 102-207 4.24e-60

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


Pssm-ID: 459863  Cd Length: 106  Bit Score: 195.09  E-value: 4.24e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928153611  102 RLKPWLVAQVNSCQYPGLQWVNGERKFFCIPWRHATRHGPSQEGDNTIFKAWAKETGKYTEGVDEADPAKWKANLRCALN 181
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNQEEDAAIFKAWAVHTGKYREGVDKPDPATWKTNFRCALN 80

                          90       100
                  ....*....|....*....|....*.
gi 928153611  182 KSRDFRLIYDGPRDMPPQPYKIYEVC 207
Cdd:pfam00605  81 KLPDFEEVKDRSKDDGSDPYKVYRIL 106
IRF smart00348
interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad ...
 102-208 1.71e-51

interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad repeat


Pssm-ID: 128642  Cd Length: 107  Bit Score: 172.52  E-value: 1.71e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928153611   102 RLKPWLVAQVNSCQYPGLQWVNGERKFFCIPWRHATRHGPSQEGDNTIFKAWAKETGKYTEGVDEADPAKWKANLRCALN 181
Cdd:smart00348   1 RLRPWLVEQVESGQYPGLCWEDEEKTRFRIPWKHAGRSGFDEERDAEIFKAYCVARGIYQPGGRSPDPKTWKARLRCALR 80

                           90       100
                   ....*....|....*....|....*..
gi 928153611   182 KSRDFRLIYDGPRDmPPQPYKIYEVCS 208
Cdd:smart00348  81 KSRDFEEIKDASTD-PPDPYRVYRLLP 106
IRF cd00103
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF ...
 101-208 4.78e-44

Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Viral IRFs bind to cellular IRFs; block type I and II interferons and host IRF-mediated transcriptional activation.


Pssm-ID: 238051  Cd Length: 107  Bit Score: 152.45  E-value: 4.78e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928153611 101 VRLKPWLVAQVNSCQYPGLQWVNGERKFFCIPWRHATRHGpSQEGDNTIFKAWAKETGKYTEGVDEaDPAKWKANLRCAL 180
Cdd:cd00103    2 MRLRPWLVEQVDSGTYPGLIWLDEEKTIFRIPWKHAARHD-VQEADAKIFKAWAVERGIYQPGGTP-DPAEWKARLLCAL 79

                         90       100
                 ....*....|....*....|....*...
gi 928153611 181 NKSRDFRLIYDGPRDMPPQPYKIYEVCS 208
Cdd:cd00103   80 RSSRGFEEVKDKSKDTPGDPHRVYRLLP 107
PHA03247 PHA03247
large tegument protein UL36; Provisional
 257-414 9.39e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 9.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928153611  257 PSLSITEAVQPGPPMAPYSLPKEDVKWPPTLQPPVvlgPPAPDPSLLGPTPGNPAGfgELLPEVLPSLQPGPLAASLPPT 336
Cdd:PHA03247 2889 PAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQP---PPPPQPQPPPPPPPRPQP--PLAPTTDPAGAGEPSGAVPQPW 2963

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928153611  337 GEQLLPDLLISPHML---PLTDLEIKfqyrGRPPRALTISNPQGCRLFYSQLEPTQDQVElfGPVSLEQVRFPSPEDIPS 413
Cdd:PHA03247 2964 LGALVPGRVAVPRFRvpqPAPSREAP----ASSTPPLTGHSLSRVSSWASSLALHEETDP--PPVSLKQTLWPPDDTEDS 3037


                  .
gi 928153611  414 D 414
Cdd:PHA03247 3038 D 3038
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 207-412 1.33e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.06  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928153611  207 CSNGSAPAESQPSEDYTFGAGEEEEEEEEDVSSGPFLAASACTDVLQRMLPSLSIteaVQPGPPMAPYSLPKEdvkwppt 286
Cdd:pfam03154 176 AQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTL---IQQTPTLHPQRLPSP------- 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928153611  287 lQPPVVLGPPAPDPSLLGPTPGNPAGFGELLPEVLPSLQPGP--LAASLPPTGEQLLPDLLISP-HMLPLTDLEIKFQYR 363
Cdd:pfam03154 246 -HPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPshMQHPVPPQPFPLTPQSSQSQvPPGPSPAAPGQSQQR 324

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 928153611  364 GRPPRALTISNPQgcrlfysqlEPTQDQVELFGPVSLEQVRFPSPEDIP 412
Cdd:pfam03154 325 IHTPPSQSQLQSQ---------QPPREQPLPPAPLSMPHIKPPPTTPIP 364
 
Name Accession Description Interval E-value
IRF-3 pfam10401
Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the ...
 353-537 1.77e-92

Interferon-regulatory factor 3; This is the interferon-regulatory factor 3 chain of the hetero-dimeric structure which also contains the shorter chain CREB-binding protein. These two subunits make up the DRAF1 (double-stranded RNA-activated factor 1). Viral dsRNA produced during viral transcription or replication leads to the activation of DRAF1. The DNA-binding specificity of DRAF1 correlates with transcriptional induction of ISG (interferon-alpha,beta-stimulated gene). IRF-3 preexists in the cytoplasm of uninfected cells and translocates to the nucleus following viral infection. Translocation of IRF-3 is accompanied by an increase in serine and threonine phosphorylation, and association with the CREB coactivator occurs only after infection.


Pssm-ID: 463076  Cd Length: 180  Bit Score: 282.22  E-value: 1.77e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928153611  353 LTDLEIKFQYRGRPPRALTISNPQGCRLFYsqlEPTQDQVELFGPVSLEQVRFPSPEDIPSDKQRFYTNQLLDVLDRGLI 432
Cdd:pfam10401   1 DTDLEITFFYRGRLVLELTVSSPEGCRLSY---GPPDPQVALYGPVALQQVRFPDPDGIPDERQREYTRRLLNVLERGLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928153611  433 LQLQGQDLYAIRLCQCKVFWSGPCASaHGSHPNPIQREVKTKLFSLEHFLNELILFQKGQTnTPPPFEIFFCFGEEWPDR 512
Cdd:pfam10401  78 LWVAGQGLYAKRLCQSRVFWSGPEAP-GGDKPNKLERDATVKLFDLAKFLRELILFQEGRG-RSPDYTITLCFGEEWPDD 155

                         170       180
                  ....*....|....*....|....*
gi 928153611  513 KPREKKLITVQVVPVAARLLLEMFS 537
Cdd:pfam10401 156 KPREKKLITVQVVPLFARQLLEMAS 180
IRF pfam00605
Interferon regulatory factor transcription factor; This family of transcription factors are ...
 102-207 4.24e-60

Interferon regulatory factor transcription factor; This family of transcription factors are important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. Three of the five conserved tryptophan residues bind to DNA.


Pssm-ID: 459863  Cd Length: 106  Bit Score: 195.09  E-value: 4.24e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928153611  102 RLKPWLVAQVNSCQYPGLQWVNGERKFFCIPWRHATRHGPSQEGDNTIFKAWAKETGKYTEGVDEADPAKWKANLRCALN 181
Cdd:pfam00605   1 RLRPWLVEQIDSGKYPGLEWLDEEKTIFRIPWKHASRQDWNQEEDAAIFKAWAVHTGKYREGVDKPDPATWKTNFRCALN 80

                          90       100
                  ....*....|....*....|....*.
gi 928153611  182 KSRDFRLIYDGPRDMPPQPYKIYEVC 207
Cdd:pfam00605  81 KLPDFEEVKDRSKDDGSDPYKVYRIL 106
IRF smart00348
interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad ...
 102-208 1.71e-51

interferon regulatory factor; interferon regulatory factor, also known as trytophan pentad repeat


Pssm-ID: 128642  Cd Length: 107  Bit Score: 172.52  E-value: 1.71e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928153611   102 RLKPWLVAQVNSCQYPGLQWVNGERKFFCIPWRHATRHGPSQEGDNTIFKAWAKETGKYTEGVDEADPAKWKANLRCALN 181
Cdd:smart00348   1 RLRPWLVEQVESGQYPGLCWEDEEKTRFRIPWKHAGRSGFDEERDAEIFKAYCVARGIYQPGGRSPDPKTWKARLRCALR 80

                           90       100
                   ....*....|....*....|....*..
gi 928153611   182 KSRDFRLIYDGPRDmPPQPYKIYEVCS 208
Cdd:smart00348  81 KSRDFEEIKDASTD-PPDPYRVYRLLP 106
IRF cd00103
Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF ...
 101-208 4.78e-44

Interferon Regulatory Factor (IRF); also known as tryptophan pentad repeat. The family of IRF transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Viral IRFs bind to cellular IRFs; block type I and II interferons and host IRF-mediated transcriptional activation.


Pssm-ID: 238051  Cd Length: 107  Bit Score: 152.45  E-value: 4.78e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928153611 101 VRLKPWLVAQVNSCQYPGLQWVNGERKFFCIPWRHATRHGpSQEGDNTIFKAWAKETGKYTEGVDEaDPAKWKANLRCAL 180
Cdd:cd00103    2 MRLRPWLVEQVDSGTYPGLIWLDEEKTIFRIPWKHAARHD-VQEADAKIFKAWAVERGIYQPGGTP-DPAEWKARLLCAL 79

                         90       100
                 ....*....|....*....|....*...
gi 928153611 181 NKSRDFRLIYDGPRDMPPQPYKIYEVCS 208
Cdd:cd00103   80 RSSRGFEEVKDKSKDTPGDPHRVYRLLP 107
PHA03247 PHA03247
large tegument protein UL36; Provisional
 257-414 9.39e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 9.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928153611  257 PSLSITEAVQPGPPMAPYSLPKEDVKWPPTLQPPVvlgPPAPDPSLLGPTPGNPAGfgELLPEVLPSLQPGPLAASLPPT 336
Cdd:PHA03247 2889 PAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQP---PPPPQPQPPPPPPPRPQP--PLAPTTDPAGAGEPSGAVPQPW 2963

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928153611  337 GEQLLPDLLISPHML---PLTDLEIKfqyrGRPPRALTISNPQGCRLFYSQLEPTQDQVElfGPVSLEQVRFPSPEDIPS 413
Cdd:PHA03247 2964 LGALVPGRVAVPRFRvpqPAPSREAP----ASSTPPLTGHSLSRVSSWASSLALHEETDP--PPVSLKQTLWPPDDTEDS 3037


                  .
gi 928153611  414 D 414
Cdd:PHA03247 3038 D 3038
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 207-412 1.33e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.06  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928153611  207 CSNGSAPAESQPSEDYTFGAGEEEEEEEEDVSSGPFLAASACTDVLQRMLPSLSIteaVQPGPPMAPYSLPKEdvkwppt 286
Cdd:pfam03154 176 AQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTL---IQQTPTLHPQRLPSP------- 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 928153611  287 lQPPVVLGPPAPDPSLLGPTPGNPAGFGELLPEVLPSLQPGP--LAASLPPTGEQLLPDLLISP-HMLPLTDLEIKFQYR 363
Cdd:pfam03154 246 -HPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPshMQHPVPPQPFPLTPQSSQSQvPPGPSPAAPGQSQQR 324

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 928153611  364 GRPPRALTISNPQgcrlfysqlEPTQDQVELFGPVSLEQVRFPSPEDIP 412
Cdd:pfam03154 325 IHTPPSQSQLQSQ---------QPPREQPLPPAPLSMPHIKPPPTTPIP 364
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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