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Conserved domains on  [gi|1622915381|ref|XP_014981099|]
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MHC class II transactivator isoform X8 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 804-1129 3.08e-78

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


:

Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 259.98  E-value: 3.08e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  804 LARYLKRLQPGTLRARQLLELLHCAheaEEAGIWQHVVQELpaRLSFLGTRLTPP--DAHVLGKALEAAGqdfalDLRST 881
Cdd:cd00116      1 LQLSLKGELLKTERATELLPKLLCL---QVLRLEGNTLGEE--AAKALASALRPQpsLKELCLSLNETGR-----IPRGL 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  882 GIDPSGLGSLVGLSCVTHFRAALS-DTVALWESLRQ---HGETELLQAAEEKfTIEPFKAKSLKDV-EDLGKLVQTQRTR 956
Cdd:cd00116     71 QSLLQGLTKGCGLQELDLSDNALGpDGCGVLESLLRsssLQELKLNNNGLGD-RGLRLLAKGLKDLpPALEKLVLGRNRL 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  957 S--SSEDTAGELPAVRDLKKLEFALGPIsGPQAFPKLVRILTAFSSLQHLDLDalsENKIGDEGVSQLSATFPQLKSLET 1034
Cdd:cd00116    150 EgaSCEALAKALRANRDLKELNLANNGI-GDAGIRALAEGLKANCNLEVLDLN---NNGLTDEGASALAETLASLKSLEV 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381 1035 LNLSQNSITDLGAYKLAEGLPSLAASLLRLSLYNNCICDMGAESLARVLPDMVSLRVMDVQYNKFTAAGaQQLAASLRKC 1114
Cdd:cd00116    226 LNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEG-AQLLAESLLE 304

                          330
                   ....*....|....*
gi 1622915381 1115 PHVETLAMWTPTIPF 1129
Cdd:cd00116    305 PGNELESLWVKDDSF 319
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 429-598 4.04e-49

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


:

Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 171.72  E-value: 4.04e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  429 QVIAMLGKAGQGKSYWAGAVSRAWACGRLPQY-DFVFSVPCHCLNRPGDVYRLQDLLFSLGPRPLVAADEVFSHIVKRPD 507
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGfDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  508 RILLILDAFEELEAQDGFLHStcgpalaePCSLRGLLAGLFQKKLLRGCTLLLTARPRGR--LVQSLSKADaLFELSGFS 585
Cdd:pfam05729   81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEPR-YLEVRGFS 151

                          170
                   ....*....|...
gi 1622915381  586 MEQAQAYVMRYFE 598
Cdd:pfam05729  152 ESDRKQYVRKYFS 164
NLRC4_HD2 super family cl39284
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ...
 728-833 8.34e-05

NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.


The actual alignment was detected with superfamily member pfam17776:

Pssm-ID: 465499 [Multi-domain]  Cd Length: 122  Bit Score: 43.43  E-value: 8.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  728 LQCFLGALWLALSGEIKDKELPQYLaLTPRKKRPYDNWLEGVP-----------RFLTGLIFQPRARCLGALVGPSATAf 796
Cdd:pfam17776    4 FQEFFAALFYVLSFKEEKSNPLKEF-FGLRKRESLKSLLDKALksknghldlflRFLFGLLNEENQRLLEGLLGCKLSS- 81

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1622915381  797 adRKQKVLARYLKRLQPGTLRARQLLELLHCAHEAEE 833
Cdd:pfam17776   82 --EIKQELLQWIKSLIQKELSSERFLNLFHCLYELQD 116
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 804-1129 3.08e-78

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 259.98  E-value: 3.08e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  804 LARYLKRLQPGTLRARQLLELLHCAheaEEAGIWQHVVQELpaRLSFLGTRLTPP--DAHVLGKALEAAGqdfalDLRST 881
Cdd:cd00116      1 LQLSLKGELLKTERATELLPKLLCL---QVLRLEGNTLGEE--AAKALASALRPQpsLKELCLSLNETGR-----IPRGL 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  882 GIDPSGLGSLVGLSCVTHFRAALS-DTVALWESLRQ---HGETELLQAAEEKfTIEPFKAKSLKDV-EDLGKLVQTQRTR 956
Cdd:cd00116     71 QSLLQGLTKGCGLQELDLSDNALGpDGCGVLESLLRsssLQELKLNNNGLGD-RGLRLLAKGLKDLpPALEKLVLGRNRL 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  957 S--SSEDTAGELPAVRDLKKLEFALGPIsGPQAFPKLVRILTAFSSLQHLDLDalsENKIGDEGVSQLSATFPQLKSLET 1034
Cdd:cd00116    150 EgaSCEALAKALRANRDLKELNLANNGI-GDAGIRALAEGLKANCNLEVLDLN---NNGLTDEGASALAETLASLKSLEV 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381 1035 LNLSQNSITDLGAYKLAEGLPSLAASLLRLSLYNNCICDMGAESLARVLPDMVSLRVMDVQYNKFTAAGaQQLAASLRKC 1114
Cdd:cd00116    226 LNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEG-AQLLAESLLE 304

                          330
                   ....*....|....*
gi 1622915381 1115 PHVETLAMWTPTIPF 1129
Cdd:cd00116    305 PGNELESLWVKDDSF 319
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 429-598 4.04e-49

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 171.72  E-value: 4.04e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  429 QVIAMLGKAGQGKSYWAGAVSRAWACGRLPQY-DFVFSVPCHCLNRPGDVYRLQDLLFSLGPRPLVAADEVFSHIVKRPD 507
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGfDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  508 RILLILDAFEELEAQDGFLHStcgpalaePCSLRGLLAGLFQKKLLRGCTLLLTARPRGR--LVQSLSKADaLFELSGFS 585
Cdd:pfam05729   81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEPR-YLEVRGFS 151

                          170
                   ....*....|...
gi 1622915381  586 MEQAQAYVMRYFE 598
Cdd:pfam05729  152 ESDRKQYVRKYFS 164
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 999-1120 7.32e-12

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 69.05  E-value: 7.32e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  999 SSLQHLDLdalSENKIGDEGVSQLSATFPQLKSLETLNLSQNSITDLGAYKLAEGLPSLAASLLRLSLYNNcICDMGAES 1078
Cdd:COG5238    264 TTVETLYL---SGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNG-IGAQGAIA 339

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1622915381 1079 LARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRKCPHVETL 1120
Cdd:COG5238    340 LAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLREL 381
NLRC4_HD2 pfam17776
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ...
 728-833 8.34e-05

NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.


Pssm-ID: 465499 [Multi-domain]  Cd Length: 122  Bit Score: 43.43  E-value: 8.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  728 LQCFLGALWLALSGEIKDKELPQYLaLTPRKKRPYDNWLEGVP-----------RFLTGLIFQPRARCLGALVGPSATAf 796
Cdd:pfam17776    4 FQEFFAALFYVLSFKEEKSNPLKEF-FGLRKRESLKSLLDKALksknghldlflRFLFGLLNEENQRLLEGLLGCKLSS- 81

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1622915381  797 adRKQKVLARYLKRLQPGTLRARQLLELLHCAHEAEE 833
Cdd:pfam17776   82 --EIKQELLQWIKSLIQKELSSERFLNLFHCLYELQD 116
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
1029-1054 9.74e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 37.39  E-value: 9.74e-04
                            10        20
                    ....*....|....*....|....*.
gi 1622915381  1029 LKSLETLNLSQNSITDLGAYKLAEGL 1054
Cdd:smart00368    1 NPSLRELDLSNNKLGDEGARALAEAL 26
LRR_8 pfam13855
Leucine rich repeat;
999-1045 8.71e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 8.71e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1622915381  999 SSLQHLDLDAlseNKIgdEGVSQlsATFPQLKSLETLNLSQNSITDL 1045
Cdd:pfam13855    1 PNLRSLDLSN---NRL--TSLDD--GAFKGLSNLKVLDLSNNLLTTL 40
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 804-1129 3.08e-78

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 259.98  E-value: 3.08e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  804 LARYLKRLQPGTLRARQLLELLHCAheaEEAGIWQHVVQELpaRLSFLGTRLTPP--DAHVLGKALEAAGqdfalDLRST 881
Cdd:cd00116      1 LQLSLKGELLKTERATELLPKLLCL---QVLRLEGNTLGEE--AAKALASALRPQpsLKELCLSLNETGR-----IPRGL 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  882 GIDPSGLGSLVGLSCVTHFRAALS-DTVALWESLRQ---HGETELLQAAEEKfTIEPFKAKSLKDV-EDLGKLVQTQRTR 956
Cdd:cd00116     71 QSLLQGLTKGCGLQELDLSDNALGpDGCGVLESLLRsssLQELKLNNNGLGD-RGLRLLAKGLKDLpPALEKLVLGRNRL 149

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  957 S--SSEDTAGELPAVRDLKKLEFALGPIsGPQAFPKLVRILTAFSSLQHLDLDalsENKIGDEGVSQLSATFPQLKSLET 1034
Cdd:cd00116    150 EgaSCEALAKALRANRDLKELNLANNGI-GDAGIRALAEGLKANCNLEVLDLN---NNGLTDEGASALAETLASLKSLEV 225

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381 1035 LNLSQNSITDLGAYKLAEGLPSLAASLLRLSLYNNCICDMGAESLARVLPDMVSLRVMDVQYNKFTAAGaQQLAASLRKC 1114
Cdd:cd00116    226 LNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEG-AQLLAESLLE 304

                          330
                   ....*....|....*
gi 1622915381 1115 PHVETLAMWTPTIPF 1129
Cdd:cd00116    305 PGNELESLWVKDDSF 319
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 429-598 4.04e-49

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 171.72  E-value: 4.04e-49
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  429 QVIAMLGKAGQGKSYWAGAVSRAWACGRLPQY-DFVFSVPCHCLNRPGDVYRLQDLLFSLGPRPLVAADEVFSHIVKRPD 507
Cdd:pfam05729    1 RTVILQGEAGSGKTTLLQKLALLWAQGKLPQGfDFVFFLPCRELSRSGNARSLADLLFSQWPEPAAPVSEVWAVILELPE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  508 RILLILDAFEELEAQDGFLHStcgpalaePCSLRGLLAGLFQKKLLRGCTLLLTARPRGR--LVQSLSKADaLFELSGFS 585
Cdd:pfam05729   81 RLLLILDGLDELVSDLGQLDG--------PCPVLTLLSSLLRKKLLPGASLLLTVRPDALrdLRRGLEEPR-YLEVRGFS 151

                          170
                   ....*....|...
gi 1622915381  586 MEQAQAYVMRYFE 598
Cdd:pfam05729  152 ESDRKQYVRKYFS 164
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 999-1120 7.32e-12

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 69.05  E-value: 7.32e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  999 SSLQHLDLdalSENKIGDEGVSQLSATFPQLKSLETLNLSQNSITDLGAYKLAEGLPSLAASLLRLSLYNNcICDMGAES 1078
Cdd:COG5238    264 TTVETLYL---SGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNG-IGAQGAIA 339

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1622915381 1079 LARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRKCPHVETL 1120
Cdd:COG5238    340 LAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLREL 381
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 1002-1137 1.10e-11

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 68.28  E-value: 1.10e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381 1002 QHLDLDALSENKIGDEGVSQLSATFPQLKSLETLNLSQNSITDLGAYKLAEGLpSLAASLLRLSLYNNCICDMGAESLAR 1081
Cdd:COG5238    180 NSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEAL-KGNKSLTTLDLSNNQIGDEGVIALAE 258

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381 1082 VLPDMVSLRVMDVQYNKFTAAGAQQLAASLRKCPHVETLAMWTPTIPF----SVQEHLQQ 1137
Cdd:COG5238    259 ALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDegaiALAEGLQG 318
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 991-1142 2.04e-11

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 67.51  E-value: 2.04e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  991 LVRILTAFSSLQHLDLdalSENKIGDEGVSQLSATFPQLKSLETLNLSQNSITDLGAYKLAEGLpSLAASLLRLSLYNNC 1070
Cdd:COG5238    284 LAKALQGNTTLTSLDL---SVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKAL-QENTTLHSLDLSDNQ 359

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622915381 1071 ICDMGAESLARVLPDMVSLRVMDVQYNKFTAAGAQQLAASLRKcPHVETLAMWTPTIPFSVQEHLQQQDSRI 1142
Cdd:COG5238    360 IGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQT-NRLHTLILDGNLIGAEAQQRLEQLLERI 430
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
316-1010 1.49e-08

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 59.05  E-value: 1.49e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  316 PEPALISRANMTEHKTSPTQRQAAGEVSNKLPKWPESVEQFYRSLQDTYRAEPTGPDGILMEVDLVQARLERSSSKSLER 395
Cdd:COG5635     63 SRSALSAAALLARALSALLLVLLLLESLLLLLLLLLLLAEALLALLELAALLKAVLLSLSGGSDLVLLLSESDLLLALLI 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  396 ELATPDWAERQLAQGGLAEGLLAAKEHRRPRET-----QVIAMLGKAGQGKS----YWAgavSRAWACGRLPQYDFVFSV 466
Cdd:COG5635    143 LLLDADGLLVSLDDLYVPLNLLERIESLKRLELleakkKRLLILGEPGSGKTtllrYLA---LELAERYLDAEDPIPILI 219

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  467 PCHCLNRPGDvyrLQDLLFSLGPRPLVAADEVFSHIVKRpDRILLILDAFEELEAQDGFLHstcgpalaepcsLRGLLAG 546
Cdd:COG5635    220 ELRDLAEEAS---LEDLLAEALEKRGGEPEDALERLLRN-GRLLLLLDGLDEVPDEADRDE------------VLNQLRR 283

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  547 LFQKklLRGCTLLLTARPRGRLVQSLSKADAlFELSGFSMEQAQAYVMRYFECsgMTEHQDRALALLRDRPFLLSHSHSP 626
Cdd:COG5635    284 FLER--YPKARVIITSRPEGYDSSELEGFEV-LELAPLSDEQIEEFLKKWFEA--TERKAERLLEALEENPELRELARNP 358

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  627 TLCQAVCQLsealleLGEDAELPSTLTGLYVGLL---------GRAALNGPPGALAE----LAKLAWELgrrHQStlQEN 693
Cdd:COG5635    359 LLLTLLALL------LRERGELPDTRAELYEQFVelllerwdeQRGLTIYRELSREElrelLSELALAM---QEN--GRT 427

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  694 QFPSADVRTWAMAKGLVQHPPGATESELAFPSFLLQC---------------FLGALWLAlsgeikdkELPQYLALTPRK 758
Cdd:COG5635    428 EFAREELEEILREYLGRRKDAEALLDELLLRTGLLVErgegrysfahrsfqeYLAARALV--------EELDEELLELLA 499

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  759 KRPYDNWLEGVPRFLTGLIFQPRARCL---GALVGPSATAFADRKQKVLARYLKRLQPGTLRARQLLELLHCAHEAEEAG 835
Cdd:COG5635    500 EHLEDPRWREVLLLLAGLLDDVKQIKElidALLARDDAAALALAAALLLALLLALALLALLALLLLLRLLLALLALLLLA 579

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  836 IWQHVVQELPARLSFLGTRLTPPDAHVLGKALEAAGQDFALDLRSTGIDPSGLGSLVGL--SCVTHFRAALSDTVALWES 913
Cdd:COG5635    580 LLLLLLLALLLALLALDLGLAALLLLLLLLLLLLLLLALALLLALLLLLLLLLLAELLLlaLLALVLLSLLLASRLLLIT 659

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  914 LRQHGETELLQAAEEKFTIEPFKAKSLKDVEDLGKLVQTQRTRSSSEDTAGELPAVRDLKKLEFALGPISGPQAFPKLVR 993
Cdd:COG5635    660 LLLLAAASAALLLLLLLLLAELLLALLALASLLLLLLLALALALALLLLAVLLAAALDLLLLLVLLLALLLVLALALSLL 739

                          730
                   ....*....|....*..
gi 1622915381  994 ILTAFSSLQHLDLDALS 1010
Cdd:COG5635    740 LLALALLLAGALLLESS 756
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
995-1120 1.86e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.39  E-value: 1.86e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  995 LTAFSSLQHLDLdalSENKIGDegvsqLSATFPQLKSLETLNLSQNSITDLGAY-----KLAE-GLpslaasllrlslYN 1068
Cdd:COG4886    109 LSNLTNLESLDL---SGNQLTD-----LPEELANLTNLKELDLSNNQLTDLPEPlgnltNLKSlDL------------SN 168

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1622915381 1069 NCIcdmgaESLARVLPDMVSLRVMDVQYNKFTAagaqqLAASLRKCPHVETL 1120
Cdd:COG4886    169 NQL-----TDLPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEEL 210
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 820-1054 2.67e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 47.86  E-value: 2.67e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  820 QLLELLHCAHEAEEAGIWQHVVQELPARLSFLGT-RLTPPDAHVLGKALEAAGQDFALDLRSTGIDPSGLGSLV----GL 894
Cdd:COG5238    156 VHLLGLAARLGLLAAISMAKALQNNSVETVYLGCnQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAealkGN 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  895 SCVTHFRaaLSDT-------VALWESLRQHGETELLQAAEEKFTIEPFK--AKSLKDVEDLGKLV--QTQRTRSSSEDTA 963
Cdd:COG5238    236 KSLTTLD--LSNNqigdegvIALAEALKNNTTVETLYLSGNQIGAEGAIalAKALQGNTTLTSLDlsVNRIGDEGAIALA 313

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  964 GELPAVRDLKKLEFALGPISGPQAFPkLVRILTAFSSLQHLDLdalSENKIGDEGVSQLsATFPQL-KSLETLNLSQNSI 1042
Cdd:COG5238    314 EGLQGNKTLHTLNLAYNGIGAQGAIA-LAKALQENTTLHSLDL---SDNQIGDEGAIAL-AKYLEGnTTLRELNLGKNNI 388

                          250
                   ....*....|..
gi 1622915381 1043 TDLGAYKLAEGL 1054
Cdd:COG5238    389 GKQGAEALIDAL 400
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
995-1045 4.02e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.62  E-value: 4.02e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1622915381  995 LTAFSSLQHLDLdalSENKIGDegvsqLSATFPQLKSLETLNLSQNSITDL 1045
Cdd:COG4886    201 LGNLTNLEELDL---SGNQLTD-----LPEPLANLTNLETLDLSNNQLTDL 243
NLRC4_HD2 pfam17776
NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein ...
 728-833 8.34e-05

NLRC4 helical domain HD2; This entry represents a helical domain found in the NLRC4 protein and NOD2 protein.


Pssm-ID: 465499 [Multi-domain]  Cd Length: 122  Bit Score: 43.43  E-value: 8.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381  728 LQCFLGALWLALSGEIKDKELPQYLaLTPRKKRPYDNWLEGVP-----------RFLTGLIFQPRARCLGALVGPSATAf 796
Cdd:pfam17776    4 FQEFFAALFYVLSFKEEKSNPLKEF-FGLRKRESLKSLLDKALksknghldlflRFLFGLLNEENQRLLEGLLGCKLSS- 81

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1622915381  797 adRKQKVLARYLKRLQPGTLRARQLLELLHCAHEAEE 833
Cdd:pfam17776   82 --EIKQELLQWIKSLIQKELSSERFLNLFHCLYELQD 116
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 1009-1120 1.72e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.55  E-value: 1.72e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622915381 1009 LSENKIGDEGVSQLS-ATFPQLKSLETLNLSQNSITDLGAYKLAEGLPSLAASLLRLSLyNNCICDMGAESLARVLPDMV 1087
Cdd:COG5238    158 LLGLAARLGLLAAISmAKALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLK-RNPIGDEGAEILAEALKGNK 236

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1622915381 1088 SLRVMDVQYNKFTAAGAQQLAASLRKCPHVETL 1120
Cdd:COG5238    237 SLTTLDLSNNQIGDEGVIALAEALKNNTTVETL 269
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
972-1047 2.10e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.31  E-value: 2.10e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622915381  972 LKKLEFALGPISG-PQAFPKLvriltafSSLQHLDLdalSENKIGDegvsqLSATFPQLKSLETLNLSQNSITDLGA 1047
Cdd:COG4886    161 LKSLDLSNNQLTDlPEELGNL-------TNLKELDL---SNNQITD-----LPEPLGNLTNLEELDLSGNQLTDLPE 222
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
1029-1054 9.74e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 37.39  E-value: 9.74e-04
                            10        20
                    ....*....|....*....|....*.
gi 1622915381  1029 LKSLETLNLSQNSITDLGAYKLAEGL 1054
Cdd:smart00368    1 NPSLRELDLSNNKLGDEGARALAEAL 26
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
1088-1112 1.01e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 37.39  E-value: 1.01e-03
                            10        20
                    ....*....|....*....|....*
gi 1622915381  1088 SLRVMDVQYNKFTAAGAQQLAASLR 1112
Cdd:smart00368    3 SLRELDLSNNKLGDEGARALAEALK 27
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 993-1045 6.24e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 6.24e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1622915381  993 RILTAFS-SLQHLDLdalSENKIGDegVSQLSAtfpqLKSLETLNLSQNSITDL 1045
Cdd:cd21340    113 RSLAALSnSLRVLNI---SGNNIDS--LEPLAP----LRNLEQLDASNNQISDL 157
LRR_8 pfam13855
Leucine rich repeat;
999-1045 8.71e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 8.71e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1622915381  999 SSLQHLDLDAlseNKIgdEGVSQlsATFPQLKSLETLNLSQNSITDL 1045
Cdd:pfam13855    1 PNLRSLDLSN---NRL--TSLDD--GAFKGLSNLKVLDLSNNLLTTL 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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