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Conserved domains on  [gi|966926509|ref|XP_014986035|]
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protein ABHD14B isoform X2 [Macaca mulatta]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 8-209 3.16e-24

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 95.07  E-value: 3.16e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966926509   8 HEGTIQVQGQALFFREARPSsGQAhfsVLLLHGIRFSSETWQNLgtLHRLAqAGYQAVAIDLPGLGHSKEAAAPVPIGEL 87
Cdd:COG0596    3 TPRFVTVDGVRLHYREAGPD-GPP---VVLLHGLPGSSYEWRPL--IPALA-AGYRVIAPDLRGHGRSDKPAGGYTLDDL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966926509  88 ApgSFLAAVVDALELGPPVVISPSLSGMYSLPF------------------------LTAPGSQLRGYVPVAPICTDKIN 143
Cdd:COG0596   76 A--DDLAALLDALGLERVVLVGHSMGGMVALELaarhpervaglvlvdevlaalaepLRRPGLAPEALAALLRALARTDL 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966926509 144 AANYASVKTPALIVYGDQDPMG--QSSFEHLKQLPNHRVLIMKGAGHPCYLDKPEEWHTGLLDFLQGL 209
Cdd:COG0596  154 RERLARITVPTLVIWGEKDPIVppALARRLAELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 8-209 3.16e-24

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 95.07  E-value: 3.16e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966926509   8 HEGTIQVQGQALFFREARPSsGQAhfsVLLLHGIRFSSETWQNLgtLHRLAqAGYQAVAIDLPGLGHSKEAAAPVPIGEL 87
Cdd:COG0596    3 TPRFVTVDGVRLHYREAGPD-GPP---VVLLHGLPGSSYEWRPL--IPALA-AGYRVIAPDLRGHGRSDKPAGGYTLDDL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966926509  88 ApgSFLAAVVDALELGPPVVISPSLSGMYSLPF------------------------LTAPGSQLRGYVPVAPICTDKIN 143
Cdd:COG0596   76 A--DDLAALLDALGLERVVLVGHSMGGMVALELaarhpervaglvlvdevlaalaepLRRPGLAPEALAALLRALARTDL 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966926509 144 AANYASVKTPALIVYGDQDPMG--QSSFEHLKQLPNHRVLIMKGAGHPCYLDKPEEWHTGLLDFLQGL 209
Cdd:COG0596  154 RERLARITVPTLVIWGEKDPIVppALARRLAELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
PLN02298 PLN02298
hydrolase, alpha/beta fold family protein
 7-142 1.15e-04

hydrolase, alpha/beta fold family protein


Pssm-ID: 165939 [Multi-domain]  Cd Length: 330  Bit Score: 42.07  E-value: 1.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966926509   7 QHEGTIQVQGQALFFREARPSSGQAHFSVLLL-HGI-RFSSETWQNLGTLhrLAQAGYQAVAIDLPGLGHSKEAAAPVPI 84
Cdd:PLN02298  33 SKSFFTSPRGLSLFTRSWLPSSSSPPRALIFMvHGYgNDISWTFQSTAIF--LAQMGFACFALDLEGHGRSEGLRAYVPN 110

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966926509  85 GELAPG---SFLAAVVDALELG--PPVVISPSLSGMYSLPFLTAPGSQLRGYVPVAPIC--TDKI 142
Cdd:PLN02298 111 VDLVVEdclSFFNSVKQREEFQglPRFLYGESMGGAICLLIHLANPEGFDGAVLVAPMCkiSDKI 175
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 35-118 4.73e-04

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 39.76  E-value: 4.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966926509   35 VLLLHGirfsseTWQNLGTLHRLAQAGYQAVAIDLPGLGHSKEAAAPVPigelAPGSFLAAVVDALELGPPVVISPSLSG 114
Cdd:pfam12697   1 VVLVHG------AGLSAAPLAALLAAGVAVLAPDLPGHGSSSPPPLDLA----DLADLAALLDELGAARPVVLVGHSLGG 70


                  ....
gi 966926509  115 MYSL 118
Cdd:pfam12697  71 AVAL 74
menH_SHCHC TIGR03695
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; This protein catalyzes the ...
 35-100 1.07e-03

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; This protein catalyzes the formation of SHCHC, or (1 R,6 R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, by elmination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Note that SHCHC synthase activity previously was attributed to MenD, which in fact is SEPHCHC synthase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 274729 [Multi-domain]  Cd Length: 252  Bit Score: 38.74  E-value: 1.07e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966926509   35 VLLLHGIRFSSETWQNLgtLHRLAQaGYQAVAIDLPGLGHSKEaaapvpIGELAPGSFLAAVVDAL 100
Cdd:TIGR03695   5 LVFLHGFLGSGADWQAL--IEALGP-HFRCLAIDLPGHGSSQS------PSDIERYDFEEAAQLLL 61
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 8-209 3.16e-24

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 95.07  E-value: 3.16e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966926509   8 HEGTIQVQGQALFFREARPSsGQAhfsVLLLHGIRFSSETWQNLgtLHRLAqAGYQAVAIDLPGLGHSKEAAAPVPIGEL 87
Cdd:COG0596    3 TPRFVTVDGVRLHYREAGPD-GPP---VVLLHGLPGSSYEWRPL--IPALA-AGYRVIAPDLRGHGRSDKPAGGYTLDDL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966926509  88 ApgSFLAAVVDALELGPPVVISPSLSGMYSLPF------------------------LTAPGSQLRGYVPVAPICTDKIN 143
Cdd:COG0596   76 A--DDLAALLDALGLERVVLVGHSMGGMVALELaarhpervaglvlvdevlaalaepLRRPGLAPEALAALLRALARTDL 153

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966926509 144 AANYASVKTPALIVYGDQDPMG--QSSFEHLKQLPNHRVLIMKGAGHPCYLDKPEEWHTGLLDFLQGL 209
Cdd:COG0596  154 RERLARITVPTLVIWGEKDPIVppALARRLAELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
16-207 2.54e-15

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 71.57  E-value: 2.54e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966926509  16 GQALFFREARPSsGQAHFSVLLLHGIRFSSETWQNLGtlHRLAQAGYQAVAIDLPGLGHSKEAAAPVP-IGELApgSFLA 94
Cdd:COG2267   13 GLRLRGRRWRPA-GSPRGTVVLVHGLGEHSGRYAELA--EALAAAGYAVLAFDLRGHGRSDGPRGHVDsFDDYV--DDLR 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966926509  95 AVVDALEL---GPPVVISPSLSGMYSLPFLTAPGSQLRGYVPVAP-ICTDKIN------------AANYASVKTPALIVY 158
Cdd:COG2267   88 AALDALRArpgLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAPaYRADPLLgpsarwlralrlAEALARIDVPVLVLH 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 966926509 159 GDQDPMGqsSFEHLKQL-----PNHRVLIMKGAGHPCYLDKP-EEWHTGLLDFLQ 207
Cdd:COG2267  168 GGADRVV--PPEAARRLaarlsPDVELVLLPGARHELLNEPArEEVLAAILAWLE 220
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
24-188 1.19e-09

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 56.13  E-value: 1.19e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966926509  24 ARPSSGQAHFSVLLLHGIRFSSEtwQNLGTLHRLAQAGYQAVAIDL--PGLGHSKEAAAPVPIGELAPGSFLA---AVVD 98
Cdd:COG0412   21 ARPAGGGPRPGVVVLHEIFGLNP--HIRDVARRLAAAGYVVLAPDLygRGGPGDDPDEARALMGALDPELLAAdlrAALD 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966926509  99 ALELGPPVVISP------SLSGMYSLpFLTAPGSQLRGYVPVAPICTDKINAANYASVKTPALIVYGDQDPMgqSSFEHL 172
Cdd:COG0412   99 WLKAQPEVDAGRvgvvgfCFGGGLAL-LAAARGPDLAAAVSFYGGLPADDLLDLAARIKAPVLLLYGEKDPL--VPPEQV 175

                        170       180
                 ....*....|....*....|....
gi 966926509 173 KQL--------PNHRVLIMKGAGH 188
Cdd:COG0412  176 AALeaalaaagVDVELHVYPGAGH 199
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
35-209 8.49e-07

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 48.01  E-value: 8.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966926509  35 VLLLHGIRFSSETWQNLGtlHRLAQAGYQAVAIDLPGLGHSKEAAAPVPIGElapgsFLAAVVDALE------------- 101
Cdd:COG1647   18 VLLLHGFTGSPAEMRPLA--EALAKAGYTVYAPRLPGHGTSPEDLLKTTWED-----WLEDVEEAYEilkagydkvivig 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966926509 102 --LG-----------PPV----VISPSLS----GMYSLPFLT--------------APGSQLRGY--VPVAPICT----D 140
Cdd:COG1647   91 lsMGgllalllaaryPDVaglvLLSPALKiddpSAPLLPLLKylarslrgigsdieDPEVAEYAYdrTPLRALAElqrlI 170

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966926509 141 KINAANYASVKTPALIVYGDQDPM-----GQSSFEHLKQlPNHRVLIMKGAGHPCYLDK-PEEWHTGLLDFLQGL 209
Cdd:COG1647  171 REVRRDLPKITAPTLIIQSRKDEVvppesARYIYERLGS-PDKELVWLEDSGHVITLDKdREEVAEEILDFLERL 244
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 35-207 2.90e-06

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 46.45  E-value: 2.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966926509  35 VLLLHGIRFSSETWQNLGtlHRLAQAGYQAVAIDLPGLGHSkeAAAPVPIGELAPGSFLAAV--------VDALELGppv 106
Cdd:COG1073   40 VVVAHGNGGVKEQRALYA--QRLAELGFNVLAFDYRGYGES--EGEPREEGSPERRDARAAVdylrtlpgVDPERIG--- 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966926509 107 VISPSLSGMYSL----------------PF----------------LTAPGSQLRGYVPVAPICTDKINAANYAS-VKTP 153
Cdd:COG1073  113 LLGISLGGGYALnaaatdprvkavildsPFtsledlaaqrakeargAYLPGVPYLPNVRLASLLNDEFDPLAKIEkISRP 192

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 966926509 154 ALIVYGDQDP-----MGQSSFEHLKQlpNHRVLIMKGAGH-PCYLDKPEEWHTGLLDFLQ 207
Cdd:COG1073  193 LLFIHGEKDEavpfyMSEDLYEAAAE--PKELLIVPGAGHvDLYDRPEEEYFDKLAEFFK 250
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
35-206 5.29e-05

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 42.70  E-value: 5.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966926509  35 VLLLHGIRFSSEtWQNLGTLHRLAQAGYQAVAIDLPGLGHSKEAAAPVPIGELApgsflaAVVDALELGPPV------VI 108
Cdd:COG1506   26 VVYVHGGPGSRD-DSFLPLAQALASRGYAVLAPDYRGYGESAGDWGGDEVDDVL------AAIDYLAARPYVdpdrigIY 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966926509 109 SPSLSGMYSLPFLTAPGSQLRGYVPVAPICT--------------------------DKINAANYA-SVKTPALIVYGDQ 161
Cdd:COG1506   99 GHSYGGYMALLAAARHPDRFKAAVALAGVSDlrsyygttreyterlmggpwedpeayAARSPLAYAdKLKTPLLLIHGEA 178

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 966926509 162 D---PMGQSS--FEHLKQL-PNHRVLIMKGAGHPCYLDKPEEWHTGLLDFL 206
Cdd:COG1506  179 DdrvPPEQAErlYEALKKAgKPVELLVYPGEGHGFSGAGAPDYLERILDFL 229
PLN02298 PLN02298
hydrolase, alpha/beta fold family protein
 7-142 1.15e-04

hydrolase, alpha/beta fold family protein


Pssm-ID: 165939 [Multi-domain]  Cd Length: 330  Bit Score: 42.07  E-value: 1.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966926509   7 QHEGTIQVQGQALFFREARPSSGQAHFSVLLL-HGI-RFSSETWQNLGTLhrLAQAGYQAVAIDLPGLGHSKEAAAPVPI 84
Cdd:PLN02298  33 SKSFFTSPRGLSLFTRSWLPSSSSPPRALIFMvHGYgNDISWTFQSTAIF--LAQMGFACFALDLEGHGRSEGLRAYVPN 110

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 966926509  85 GELAPG---SFLAAVVDALELG--PPVVISPSLSGMYSLPFLTAPGSQLRGYVPVAPIC--TDKI 142
Cdd:PLN02298 111 VDLVVEdclSFFNSVKQREEFQglPRFLYGESMGGAICLLIHLANPEGFDGAVLVAPMCkiSDKI 175
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 35-80 1.49e-04

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 39.81  E-value: 1.49e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 966926509  35 VLLLHGIRFSSETWQNLGtlHRLAQAGYQAVAIDLPGLGHSKEAAA 80
Cdd:COG1075    8 VVLVHGLGGSAASWAPLA--PRLRAAGYPVYALNYPSTNGSIEDSA 51
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 11-114 1.56e-04

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 41.85  E-value: 1.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966926509  11 TIQVQGQALFFREARPSSGQAhfsVLLLHGirFSSE--TWqnLGTLHRLAqAGYQAVAIDLPGLGHSKEAAAPVPIGELA 88
Cdd:PRK14875 113 KARIGGRTVRYLRLGEGDGTP---VVLIHG--FGGDlnNW--LFNHAALA-AGRPVIALDLPGHGASSKAVGAGSLDELA 184

                         90       100
                 ....*....|....*....|....*.
gi 966926509  89 pgSFLAAVVDALELGPPVVISPSLSG 114
Cdd:PRK14875 185 --AAVLAFLDALGIERAHLVGHSMGG 208
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 35-118 4.73e-04

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 39.76  E-value: 4.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966926509   35 VLLLHGirfsseTWQNLGTLHRLAQAGYQAVAIDLPGLGHSKEAAAPVPigelAPGSFLAAVVDALELGPPVVISPSLSG 114
Cdd:pfam12697   1 VVLVHG------AGLSAAPLAALLAAGVAVLAPDLPGHGSSSPPPLDLA----DLADLAALLDELGAARPVVLVGHSLGG 70


                  ....
gi 966926509  115 MYSL 118
Cdd:pfam12697  71 AVAL 74
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 35-115 5.01e-04

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 39.80  E-value: 5.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966926509   35 VLLLHGIRFSSETWQNLGTLhrLAQAGYQAVAIDLPGLGHSKEAAAPVPIGELAPGSFLAAVVDALELGPPVVISPSLSG 114
Cdd:pfam00561   3 VLLLHGLPGSSDLWRKLAPA--LARDGFRVIALDLRGFGKSSRPKAQDDYRTDDLAEDLEYILEALGLEKVNLVGHSMGG 80


                  .
gi 966926509  115 M 115
Cdd:pfam00561  81 L 81
menH_SHCHC TIGR03695
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; This protein catalyzes the ...
 35-100 1.07e-03

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; This protein catalyzes the formation of SHCHC, or (1 R,6 R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, by elmination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Note that SHCHC synthase activity previously was attributed to MenD, which in fact is SEPHCHC synthase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 274729 [Multi-domain]  Cd Length: 252  Bit Score: 38.74  E-value: 1.07e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966926509   35 VLLLHGIRFSSETWQNLgtLHRLAQaGYQAVAIDLPGLGHSKEaaapvpIGELAPGSFLAAVVDAL 100
Cdd:TIGR03695   5 LVFLHGFLGSGADWQAL--IEALGP-HFRCLAIDLPGHGSSQS------PSDIERYDFEEAAQLLL 61
PLN02679 PLN02679
hydrolase, alpha/beta fold family protein
 150-209 3.88e-03

hydrolase, alpha/beta fold family protein


Pssm-ID: 178283 [Multi-domain]  Cd Length: 360  Bit Score: 37.51  E-value: 3.88e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966926509 150 VKTPALIVYGDQD-------PMGQSSFEHLKQLPNHRVLIMKGAGHPCYLDKPEEWHTGLLDFLQGL 209
Cdd:PLN02679 291 ISLPILVLWGDQDpftpldgPVGKYFSSLPSQLPNVTLYVLEGVGHCPHDDRPDLVHEKLLPWLAQL 357
YheT COG0429
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
35-105 8.39e-03

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


Pssm-ID: 440198 [Multi-domain]  Cd Length: 323  Bit Score: 36.27  E-value: 8.39e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 966926509  35 VLLLHGIRFSSETWQNLGTLHRLAQAGYQAVAIDLPglGHSKEAaapvpigELAPGSF-------LAAVVDAL-ELGPP 105
Cdd:COG0429   64 VVLLHGLEGSSDSHYARGLARALYARGWDVVRLNFR--GCGGEP-------NLLPRLYhsgdtedLVWVLAHLrARYPY 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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