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Conserved domains on  [gi|966947025|ref|XP_014995567|]
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interleukin-31 receptor subunit alpha [Macaca mulatta]

Protein Classification

FN3 domain-containing protein( domain architecture ID 10705451)

FN3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 421-501 7.03e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


:

Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.31  E-value: 7.03e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947025   421 PSKGPETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYGLESLKRKTSYTVRVMASTSA 500
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   .
gi 966947025   501 G 501
Cdd:smart00060  81 G 81
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 123-222 5.88e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 5.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947025 123 EPPEIFSVKPVlgIKRMIRIEWIKPElAPVSSDLKYALRFRTVNSTSWMEVNfakNRKDTNQTYNLMGLQAFTEYVVALR 202
Cdd:cd00063    2 SPPTNLRVTDV--TSTSVTLSWTPPE-DDGGPITGYVVEYREKGSGDWKEVE---VTPGSETSYTLTGLKPGTEYEFRVR 75

                         90       100
                 ....*....|....*....|
gi 966947025 203 CavKESKFWSDWSQEKMGMT 222
Cdd:cd00063   76 A--VNGGGESPPSESVTVTT 93
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 21-113 3.65e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam09067:

Pssm-ID: 473895  Cd Length: 104  Bit Score: 40.48  E-value: 3.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947025   21 LPAKPENISCVYYYRKNLTCTWSPGKETSYTQytakrTYAFGKKHDN-----C---TTSSSTSENRASCSFFLPRITIPD 92
Cdd:pfam09067   7 LPEKPEDIKCFSREKEDFTCFWEEEEDGGLPT-----TYSFSYAYENetvkeCplySTSGANSTRLFICFFPKNDVSLFV 81

                          90       100
                  ....*....|....*....|.
gi 966947025   93 NYTIEVEAENGDGVIKSDMTC 113
Cdd:pfam09067  82 PLHITVVATNTNGTRYSRELS 102
 
Name Accession Description Interval E-value
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 421-501 7.03e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.31  E-value: 7.03e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947025   421 PSKGPETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYGLESLKRKTSYTVRVMASTSA 500
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   .
gi 966947025   501 G 501
Cdd:smart00060  81 G 81
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 421-512 5.28e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 5.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947025 421 PSKGPETKVENIGVKTVTITWKeiPKSERKGIICNYTIFYQAEGGKGFSK--TVNSSILQYGLESLKRKTSYTVRVMAST 498
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWT--PPEDDGGPITGYVVEYREKGSGDWKEveVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                         90
                 ....*....|....*
gi 966947025 499 SAG-GINGTSINFKT 512
Cdd:cd00063   79 GGGeSPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 123-222 5.88e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 5.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947025 123 EPPEIFSVKPVlgIKRMIRIEWIKPElAPVSSDLKYALRFRTVNSTSWMEVNfakNRKDTNQTYNLMGLQAFTEYVVALR 202
Cdd:cd00063    2 SPPTNLRVTDV--TSTSVTLSWTPPE-DDGGPITGYVVEYREKGSGDWKEVE---VTPGSETSYTLTGLKPGTEYEFRVR 75

                         90       100
                 ....*....|....*....|
gi 966947025 203 CavKESKFWSDWSQEKMGMT 222
Cdd:cd00063   76 A--VNGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
428-501 3.76e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 42.79  E-value: 3.76e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966947025  428 KVENIGVKTVTITWKeiPKSERKGIICNYTIFYQAEGGKG--FSKTVNSSILQYGLESLKRKTSYTVRVMASTSAG 501
Cdd:pfam00041   7 TVTDVTSTSLTVSWT--PPPDGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 21-113 3.65e-04

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 40.48  E-value: 3.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947025   21 LPAKPENISCVYYYRKNLTCTWSPGKETSYTQytakrTYAFGKKHDN-----C---TTSSSTSENRASCSFFLPRITIPD 92
Cdd:pfam09067   7 LPEKPEDIKCFSREKEDFTCFWEEEEDGGLPT-----TYSFSYAYENetvkeCplySTSGANSTRLFICFFPKNDVSLFV 81

                          90       100
                  ....*....|....*....|.
gi 966947025   93 NYTIEVEAENGDGVIKSDMTC 113
Cdd:pfam09067  82 PLHITVVATNTNGTRYSRELS 102
 
Name Accession Description Interval E-value
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 421-501 7.03e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.31  E-value: 7.03e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947025   421 PSKGPETKVENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYGLESLKRKTSYTVRVMASTSA 500
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   .
gi 966947025   501 G 501
Cdd:smart00060  81 G 81
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 421-512 5.28e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 5.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947025 421 PSKGPETKVENIGVKTVTITWKeiPKSERKGIICNYTIFYQAEGGKGFSK--TVNSSILQYGLESLKRKTSYTVRVMAST 498
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWT--PPEDDGGPITGYVVEYREKGSGDWKEveVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                         90
                 ....*....|....*
gi 966947025 499 SAG-GINGTSINFKT 512
Cdd:cd00063   79 GGGeSPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 123-222 5.88e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.18  E-value: 5.88e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947025 123 EPPEIFSVKPVlgIKRMIRIEWIKPElAPVSSDLKYALRFRTVNSTSWMEVNfakNRKDTNQTYNLMGLQAFTEYVVALR 202
Cdd:cd00063    2 SPPTNLRVTDV--TSTSVTLSWTPPE-DDGGPITGYVVEYREKGSGDWKEVE---VTPGSETSYTLTGLKPGTEYEFRVR 75

                         90       100
                 ....*....|....*....|
gi 966947025 203 CavKESKFWSDWSQEKMGMT 222
Cdd:cd00063   76 A--VNGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
428-501 3.76e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 42.79  E-value: 3.76e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966947025  428 KVENIGVKTVTITWKeiPKSERKGIICNYTIFYQAEGGKG--FSKTVNSSILQYGLESLKRKTSYTVRVMASTSAG 501
Cdd:pfam00041   7 TVTDVTSTSLTVSWT--PPPDGNGPITGYEVEYRPKNSGEpwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 21-113 3.65e-04

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 40.48  E-value: 3.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947025   21 LPAKPENISCVYYYRKNLTCTWSPGKETSYTQytakrTYAFGKKHDN-----C---TTSSSTSENRASCSFFLPRITIPD 92
Cdd:pfam09067   7 LPEKPEDIKCFSREKEDFTCFWEEEEDGGLPT-----TYSFSYAYENetvkeCplySTSGANSTRLFICFFPKNDVSLFV 81

                          90       100
                  ....*....|....*....|.
gi 966947025   93 NYTIEVEAENGDGVIKSDMTC 113
Cdd:pfam09067  82 PLHITVVATNTNGTRYSRELS 102
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 27-109 5.05e-04

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 39.70  E-value: 5.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947025   27 NISCVYYYRKNLTCTWSPGKETSY-TQYTAKRTYAFGKKHDNCTTSSSTSENRASCSFFLPRITIPDNY--TIEVEAENG 103
Cdd:pfam09240   1 DLTCFIHNPSNLSCEWKPGPNAPPdTNYVLYVRKSPLGPVLQCQYYIRDDGTRIGCQFDDLEGLSSSFHqvYICVNGSSS 80


                  ....*.
gi 966947025  104 DGVIKS 109
Cdd:pfam09240  81 AGPIRS 86
IL2RB_N1 pfam18707
Interleukin-2 receptor subunit beta N-terminal domain 1; IL-2Rbeta is a member of the class I ...
 27-110 4.72e-03

Interleukin-2 receptor subunit beta N-terminal domain 1; IL-2Rbeta is a member of the class I cytokine receptor superfamily. It carries a cytokine-binding homology region, which is divided in two fibronectin type-III (FN-III) domains termed D1 and D2. Each domain contains seven beta-strands that form a sandwich of two antiparallel beta-sheets. The N-terminal D1 domain of IL-2Rbeta includes two highly conserved disulfide bridges. This entry describes D1 of the N-terminal region of IL2Rbeta.


Pssm-ID: 465844  Cd Length: 92  Bit Score: 36.99  E-value: 4.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966947025   27 NISCVYYYRKNLTCTWSPGKETSYT--QYTAKRTYAFGKKHdnCTTSSSTSENRaSCSFFL-----PRITIPDNYTIEV- 98
Cdd:pfam18707   2 SLTCFYNSRANISCVWSHDGTLQVTscHLHAKSNIRSWNKS--CELIPVEPASW-SCNLILgspnsQKFTSADTLDLSVm 78

                          90
                  ....*....|....
gi 966947025   99 --EAENGDGVIKSD 110
Cdd:pfam18707  79 csEGEEWRGVKTQD 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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