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Conserved domains on  [gi|2024404317|ref|XP_015131875|]
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protocadherin Fat 4 [Gallus gallus]

Protein Classification

Cadherin_repeat and LamG domain-containing protein( domain architecture ID 10876546)

protein containing domains Cadherin_repeat, EGF_CA, LamG, and Laminin_G_2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2195-2290 1.85e-36

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 134.75  E-value: 1.85e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2195 YRVELEENTLTGTDLIQVLATDGDEGTNGQVRYSIVSGDTGNQFRIDSVTGVITVAKPLDREKKPSYMLTVQSSDRGSSP 2274
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*.
gi 2024404317 2275 RTDTTTVNIVLKDVND 2290
Cdd:cd11304     82 LSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3131-3228 1.66e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 126.27  E-value: 1.66e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3131 HMSVTIPESHSVGAVIRTVSARDRDAAMNGLIRYNISSGNEAGNFAINTTTGTLTLAKPLDFELCQKHELIVTATDGGWV 3210
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024404317 3211 SRTGFCSVTINVIDVNDN 3228
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1357-1452 1.85e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 126.27  E-value: 1.85e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1357 SVDVLENMRVGELVSSVTATDSDSGDNADLHYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPR 1436
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 2024404317 1437 SSTMSVVIYVRDFNDN 1452
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3446-3544 5.80e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 124.73  E-value: 5.80e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3446 TYNVQISEGVPPGTHVTFVSAFDSDSvPSWSRFSYFIGSGNDNSAFSINPQTGQVTVTAELDRETLPVYNLSVLAIDSGT 3525
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDS-GENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 2024404317 3526 PSATGSASLLVTLEDINDN 3544
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1251-1347 6.39e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 124.73  E-value: 6.39e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1251 YQATISELAANLTQVLRVSASDVDEGTNGLIHYSVIKGNEEKQFAIDSSTGQVTLVGKLDHEATASYSLVIQAVDSGAVS 1330
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 2024404317 1331 LSSTCTLSIDVLDENDN 1347
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2711-2807 1.27e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.58  E-value: 1.27e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2711 PFIAEIVENLSP-RKLLTVAAVDRDSGLNGQLIYEIIEGNTENSFSINRATGEIRSVRPLDREKLSRYTLTIKASDKGTP 2789
Cdd:cd11304      1 SYEVSVPENAPPgTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024404317 2790 LQSTTVKVIINVLDENDN 2807
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2093-2186 1.43e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.58  E-value: 1.43e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2093 TYIPENTPIDTIVFKAQATDPDSGPNSYIEYSLLRP-LGNKFSIGTIDGEVRLIGELDREAVSNYTLTVVATDKGQPSLS 2171
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGnEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....*
gi 2024404317 2172 SSTDVVVIVLDINDN 2186
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2405-2500 6.20e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.65  E-value: 6.20e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2405 YSATVPEDAPTGTDILLVNSSDADASRNAVISYRLTGGNSQ--FTINPSTGQIITSALLDRETRENYTLIVVASDGGYPR 2482
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*...
gi 2024404317 2483 aLSSSTSVLVAVADVNDN 2500
Cdd:cd11304     82 -LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 242-345 1.75e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.50  E-value: 1.75e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  242 YQARVPEDAPVGASVLQVAAADADEGTNADIRYRLEGGDGGGgegasslPFEVDPESGVIRIRERLDYELCQQYSLTVQA 321
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-------LFSIDPSTGEITTAKPLDREEQSSYTLTVTA 74

                           90       100
                   ....*....|....*....|....
gi 2024404317  322 TDRGVPALSGRAEALIRLLDVNDN 345
Cdd:cd11304     75 TDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 729-825 1.97e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.50  E-value: 1.97e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  729 QYFAHIQENEPAGTYVTTVSATDPDMGPNGTVKYSISAGDTSR-FQVHGKTGIITTKIALDREEKTAYQLQIVATDGGHL 807
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024404317  808 QSQNQAIVTITVLDTQDN 825
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 613-721 2.93e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 119.73  E-value: 2.93e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  613 YQVSLAENSPSGTELLVLSAVDGDLGDNGTIRFSLqeaepavvavgpSSVTPRQVFRLDPVSGKLSTISQLDREEQAHFS 692
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI------------VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYT 69

                           90       100
                   ....*....|....*....|....*....
gi 2024404317  693 LQVLATDLGSPPLSSVARVNVSLLDVNDN 721
Cdd:cd11304     70 LTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1036-1132 6.20e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.96  E-value: 6.20e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1036 SYEITILESEPVNSRFFKVHATDKDSGVNGEIAYSIIEGNAGDAFGIFPD-GQLYIKSELDRELQERYILLVVASDRAVE 1114
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024404317 1115 PLNATVNITVILEDVNDN 1132
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1984-2082 2.05e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.41  E-value: 2.05e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1984 SYSTSLMENLAPGSAILNFSVTDADDGSNSQLSFSIASGDSMGHFGID-NSGVLSTQQPLDRESQSFYSLVVQVHDMAPL 2062
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90       100
                   ....*....|....*....|
gi 2024404317 2063 PASrytSTAQVSIILLDVND 2082
Cdd:cd11304     81 PLS---STATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 490-603 3.43e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 116.64  E-value: 3.43e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  490 VYRVNISEEVPLGSYVRGLTATDRDSGLNANLRYSIVSGNELGWFHISEHSGLVttagpgggtaghaggaSVTSGLDRET 569
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEI----------------TTAKPLDREE 64

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2024404317  570 TSQVVLNISARDQGVQPKFSYAQLVVTILDINDN 603
Cdd:cd11304     65 QSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1881-1976 1.30e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 115.10  E-value: 1.30e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1881 VYSFDIPEDATPGSLVAAILATDDDSGINGEITYTVSEDDEEGMFFLNPVTGVFNLTRALDYEAQQYYILTIRAEDGGG- 1959
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                           90
                   ....*....|....*...
gi 2024404317 1960 -QFATIRVYFNILDINDN 1976
Cdd:cd11304     81 pLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3237-3331 2.25e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 2.25e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3237 YFPNVLENAPSGTTVIRLNASDADSGPNAVIAYAIQSSDSD-LFVIDPNTGTITTQGFLDYETKQSYHLTIKAFNVPDEE 3315
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*.
gi 2024404317 3316 RCSFASVNIQLEGTNE 3331
Cdd:cd11304     82 LSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2814-2906 3.11e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.47  E-value: 3.11e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2814 IFSASVPENAPLGFTVTRVTTSDEDIGMNAISRYSIR--DTSLPFVINPSTGDITVSRLLNREDTDRYRIRVSAHDSG-- 2889
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGgp 80

                           90
                   ....*....|....*...
gi 2024404317 2890 -WTVSTDVTVFVTDVNDN 2906
Cdd:cd11304     81 pLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1783-1873 3.74e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.47  E-value: 3.74e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1783 LTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDS-FHVDPESGDLIATKRLDRERRSKYSLLVRADDG---LQS 1858
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggpPLS 83

                           90
                   ....*....|....*
gi 2024404317 1859 SDMRINITVSDVNDH 1873
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3552-3648 3.89e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.39  E-value: 3.89e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3552 QGEVMENNRAGTLVMTLQSSDPDLPPNqGPFTYYLLStGPATSYFSL-STAGVLTTTREIDREQISDFYLSVITRDSGIP 3630
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGEN-GEVTYSIVS-GNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024404317 3631 QMSSTGTVQIKVIDQNDN 3648
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 935-1028 7.60e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.62  E-value: 7.60e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  935 SVNVVENWKAGHTIFQAKALDPDEGVNGMVLYSL-KQNPKGLFSINEQTGAISLIGQLDINA-GTYQVEILASDMGVPQL 1012
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEqSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 2024404317 1013 SSTFVLTVSVHDVNDN 1028
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1464-1561 5.36e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.31  E-value: 5.36e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1464 SIIENIPVGSSVISVTANDSDADINGQLTYAIIQQTPrGNHFRIDEVRGTIFTNAEIDREFANLFELTVKATDQAVPves 1543
Cdd:cd11304      5 SVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP--- 80

                           90
                   ....*....|....*...
gi 2024404317 1544 RRFALKNVTILVMDQNDN 1561
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 4015-4178 5.37e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 100.96  E-value: 5.37e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 4015 SYGFEELSYMEFPSMDP--NNNYIYIKFATIKRNALMLYNydnQTGERAEFLALEIIEGRLRFSYNLGSGTYKLTTTKKV 4092
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAprTRLSISFSFRTTSPNGLLLYA---GSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 4093 SDGQFHTVIARRAGMAASLTVDSCSedqepgycTVSNVAVSTDWTLDVQPNrLTVGGirsVEPILQRRGQVESHDFVGCI 4172
Cdd:cd00110     78 NDGQWHSVSVERNGRSVTLSVDGER--------VVESGSPGGSALLNLDGP-LYLGG---LPEDLKSPGLPVSPGFVGCI 145


                   ....*.
gi 2024404317 4173 MEFAVN 4178
Cdd:cd00110    146 RDLKVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3341-3438 1.30e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.15  E-value: 1.30e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3341 YYFEVSEAASEGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQIDERSGQIYVSGPLDREKEERISLKVLAKNFGSir 3420
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG-- 79

                           90
                   ....*....|....*...
gi 2024404317 3421 GADIDEVTVNITILDAND 3438
Cdd:cd11304     80 PPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2914-3017 2.15e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.38  E-value: 2.15e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2914 SYYLECPELPGIGLKVTQVSATDPDEGSNGHVFYFIKSQSE--FFRINATTGEIFNKQYLRYQNssgssnvnINRHSFIV 2991
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREE--------QSSYTLTV 72

                           90       100
                   ....*....|....*....|....*.
gi 2024404317 2992 TSSDRGSPPLLSETTVTINIVDSNDN 3017
Cdd:cd11304     73 TATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2611-2703 2.28e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.38  E-value: 2.28e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2611 TFTFPENQAVGTLVTTISGSSA---RGGSLSYYIASGNLGNTFIVDQVTGQLSVGQALDFEAIQKYVVWIEARDTGFPPF 2687
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 2024404317 2688 SSYKKLEVTVVDVNDN 2703
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1141-1242 2.22e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.69  E-value: 2.22e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1141 YVFYFEEEQSGGSYVGKINAVDKDFGPNGEVRYSF--EHMQPDFELNTITGEIRSTHQFDREALmrqrgaAVFSLTVIAT 1218
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQ------SSYTLTVTAT 75

                           90       100
                   ....*....|....*....|....
gi 2024404317 1219 DQGLPkPLKDQATVQIYMKDINDN 1242
Cdd:cd11304     76 DGGGP-PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 126-233 3.15e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 3.15e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  126 SIVVTFKEDTGSGRQLILDTATDADSGTNGvdHSSYRIVSGNEEGRFRLNITlnpSGEgaflhLVSQGGLDREATPSYQL 205
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSIDPS---TGE-----ITTAKPLDREEQSSYTL 70

                           90       100
                   ....*....|....*....|....*...
gi 2024404317  206 LVQVEDKGEPRRRGYLQVNVTVQDINDN 233
Cdd:cd11304     71 TVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2299-2396 4.60e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.53  E-value: 4.60e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2299 PYNVNVPENLEtLPKVILQVVARDDDQGLNSKLTYVLVSGNEEGAFIL-SASGELRLVQSLDRERKEQYVLLITAADSGS 2377
Cdd:cd11304      1 SYEVSVPENAP-PGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 2024404317 2378 PALTGTGTITVTVDDVNDN 2396
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 834-925 5.75e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.53  E-value: 5.75e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  834 YGFVVFENVALGYHVGTVFASTMDLNTN--ISYLITTGDQRGMFAINKVTGQITTASIIDREEQAFYQLKVVASGGAV-- 909
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 2024404317  910 -TGDTIVNITVKDLNDN 925
Cdd:cd11304     82 lSSTATVTITVLDVNDN 98
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 4288-4411 1.41e-20

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 90.56  E-value: 1.41e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 4288 FRTRSENGILFHI-QESSNFTTVKIRAGKVHYISDAGiAGKVERNIPEVYTADGQWHSVRIEKNGSTTVLSVDKTHKRDI 4366
Cdd:pfam02210    1 FRTRQPNGLLLYAgGGGSDFLALELVNGRLVLRYDLG-SGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 2024404317 4367 lHVTQDFGGLNVLT-ISLGGIPPNQPFKSTV--AGFDGCISYIKYGGE 4411
Cdd:pfam02210   80 -LPPGESLLLNLNGpLYLGGLPPLLLLPALPvrAGFVGCIRDVRVNGE 126
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3026-3121 3.25e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.52  E-value: 3.25e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3026 YFTPVTKNVRAGTNLIKVTAVDdKDFGLNSEVEYFVSDESKTNKFRLDRSTGWISVSSSLMADLNKKFLFKVKAKDKGNP 3105
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATD-PDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*.
gi 2024404317 3106 PLSSEVAVEIVVTEEN 3121
Cdd:cd11304     81 PLSSTATVTITVLDVN 96
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 360-482 3.62e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.14  E-value: 3.62e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  360 FASVDENAAPGTVVALLTVSDADSPaANGNISVSILAGNEQRHFEVHsskvPNLSLIKVAAALDRERIPAYNLTVAVADn 439
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSG-ENGEVTYSIVSGNEDGLFSID----PSTGEITTAKPLDREEQSSYTLTVTATD- 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2024404317  440 yGASPPppgfptsslspdgvaatpvsRSSVASLVIFVNDINDH 482
Cdd:cd11304     77 -GGGPP--------------------LSSTATVTITVLDVNDN 98
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3900-3936 2.30e-16

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 75.37  E-value: 2.30e-16
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2024404317 3900 DIDECL-PSPCHNDGTCHNLVGGFSCSCPDGFTGMACE 3936
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1579-1661 9.60e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 9.60e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1579 IGSILTTIIAADPDEGANGEVEYEIINGDT-KTFIVDRYSGDLRVASAL-VPSQLIYNLIVSATDLGPERRKSTTEMTII 1656
Cdd:cd11304     12 PGTVVLTVSATDPDSGENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLdREEQSSYTLTVTATDGGGPPLSSTATVTIT 91


                   ....*
gi 2024404317 1657 LQGVD 1661
Cdd:cd11304     92 VLDVN 96
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2508-2595 9.88e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.43  E-value: 9.88e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2508 PYVTHVPSPTTSGSFVFAVTVTDADAGSNAELHYSLMGKNA-EKFHIDSARGAILAANELSGE--SEVTISVHVRDGGRY 2584
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDREeqSSYTLTVTATDGGGP 80

                           90
                   ....*....|.
gi 2024404317 2585 PKTDSTTVTVR 2595
Cdd:cd11304     81 PLSSTATVTIT 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1670-1772 2.13e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 74.66  E-value: 2.13e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1670 YITILKEGEPIGTNVISIEASSP-RGSEAQVEYYIVSvrcedKSLGRLFTIGRHTGVIQTAAILDREQgVRLYLVDVYAI 1748
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPdSGENGEVTYSIVS-----GNEDGLFSIDPSTGEITTAKPLDREE-QSSYTLTVTAT 75

                           90       100
                   ....*....|....*....|....
gi 2024404317 1749 EkSSVLPRTQRAEVEITLQDINDN 1772
Cdd:cd11304     76 D-GGGPPLSSTATVTITVLDVNDN 98
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3938-3973 1.51e-13

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 67.28  E-value: 1.51e-13
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2024404317 3938 DVNECLS-NPCKNGAACQNFPGTFNCICKTGYTGKTC 3973
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 35-118 2.03e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 57.71  E-value: 2.03e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317   35 VFQVLEEQPAGTWVGTI-AT------RPGFTYRLSEHHA--LFSINATSGALHTRASIDRESLASdvVDLVVL-----SS 100
Cdd:cd11304      3 EVSVPENAPPGTVVLTVsATdpdsgeNGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSS--YTLTVTatdggGP 80

                           90
                   ....*....|....*...
gi 2024404317  101 QPTYPSEVRVLVLDLNDN 118
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4467-4500 2.76e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.64  E-value: 2.76e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2024404317 4467 CAS-SPCQNGGSCEPGPqASFTCSCPESYVGQRCE 4500
Cdd:cd00054      5 CASgNPCQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3977-4012 2.10e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 2.10e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2024404317 3977 VNYCE-CNPCFNGGSCQSGLEGYYCHCPFGVFGNHCE 4012
Cdd:cd00054      2 IDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4204-4236 1.55e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 1.55e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2024404317 4204 CTT-SPCQHGGTCTDHWSWQQCQCKDGLTGDHCE 4236
Cdd:cd00054      5 CASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2195-2290 1.85e-36

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 134.75  E-value: 1.85e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2195 YRVELEENTLTGTDLIQVLATDGDEGTNGQVRYSIVSGDTGNQFRIDSVTGVITVAKPLDREKKPSYMLTVQSSDRGSSP 2274
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*.
gi 2024404317 2275 RTDTTTVNIVLKDVND 2290
Cdd:cd11304     82 LSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3131-3228 1.66e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 126.27  E-value: 1.66e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3131 HMSVTIPESHSVGAVIRTVSARDRDAAMNGLIRYNISSGNEAGNFAINTTTGTLTLAKPLDFELCQKHELIVTATDGGWV 3210
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024404317 3211 SRTGFCSVTINVIDVNDN 3228
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1357-1452 1.85e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 126.27  E-value: 1.85e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1357 SVDVLENMRVGELVSSVTATDSDSGDNADLHYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPR 1436
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 2024404317 1437 SSTMSVVIYVRDFNDN 1452
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3446-3544 5.80e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 124.73  E-value: 5.80e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3446 TYNVQISEGVPPGTHVTFVSAFDSDSvPSWSRFSYFIGSGNDNSAFSINPQTGQVTVTAELDRETLPVYNLSVLAIDSGT 3525
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDS-GENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 2024404317 3526 PSATGSASLLVTLEDINDN 3544
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1251-1347 6.39e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 124.73  E-value: 6.39e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1251 YQATISELAANLTQVLRVSASDVDEGTNGLIHYSVIKGNEEKQFAIDSSTGQVTLVGKLDHEATASYSLVIQAVDSGAVS 1330
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 2024404317 1331 LSSTCTLSIDVLDENDN 1347
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2711-2807 1.27e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.58  E-value: 1.27e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2711 PFIAEIVENLSP-RKLLTVAAVDRDSGLNGQLIYEIIEGNTENSFSINRATGEIRSVRPLDREKLSRYTLTIKASDKGTP 2789
Cdd:cd11304      1 SYEVSVPENAPPgTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024404317 2790 LQSTTVKVIINVLDENDN 2807
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2093-2186 1.43e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.58  E-value: 1.43e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2093 TYIPENTPIDTIVFKAQATDPDSGPNSYIEYSLLRP-LGNKFSIGTIDGEVRLIGELDREAVSNYTLTVVATDKGQPSLS 2171
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGnEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....*
gi 2024404317 2172 SSTDVVVIVLDINDN 2186
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2405-2500 6.20e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.65  E-value: 6.20e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2405 YSATVPEDAPTGTDILLVNSSDADASRNAVISYRLTGGNSQ--FTINPSTGQIITSALLDRETRENYTLIVVASDGGYPR 2482
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*...
gi 2024404317 2483 aLSSSTSVLVAVADVNDN 2500
Cdd:cd11304     82 -LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 242-345 1.75e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.50  E-value: 1.75e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  242 YQARVPEDAPVGASVLQVAAADADEGTNADIRYRLEGGDGGGgegasslPFEVDPESGVIRIRERLDYELCQQYSLTVQA 321
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-------LFSIDPSTGEITTAKPLDREEQSSYTLTVTA 74

                           90       100
                   ....*....|....*....|....
gi 2024404317  322 TDRGVPALSGRAEALIRLLDVNDN 345
Cdd:cd11304     75 TDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 729-825 1.97e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.50  E-value: 1.97e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  729 QYFAHIQENEPAGTYVTTVSATDPDMGPNGTVKYSISAGDTSR-FQVHGKTGIITTKIALDREEKTAYQLQIVATDGGHL 807
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024404317  808 QSQNQAIVTITVLDTQDN 825
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 613-721 2.93e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 119.73  E-value: 2.93e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  613 YQVSLAENSPSGTELLVLSAVDGDLGDNGTIRFSLqeaepavvavgpSSVTPRQVFRLDPVSGKLSTISQLDREEQAHFS 692
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI------------VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYT 69

                           90       100
                   ....*....|....*....|....*....
gi 2024404317  693 LQVLATDLGSPPLSSVARVNVSLLDVNDN 721
Cdd:cd11304     70 LTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1036-1132 6.20e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.96  E-value: 6.20e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1036 SYEITILESEPVNSRFFKVHATDKDSGVNGEIAYSIIEGNAGDAFGIFPD-GQLYIKSELDRELQERYILLVVASDRAVE 1114
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024404317 1115 PLNATVNITVILEDVNDN 1132
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1984-2082 2.05e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.41  E-value: 2.05e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1984 SYSTSLMENLAPGSAILNFSVTDADDGSNSQLSFSIASGDSMGHFGID-NSGVLSTQQPLDRESQSFYSLVVQVHDMAPL 2062
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90       100
                   ....*....|....*....|
gi 2024404317 2063 PASrytSTAQVSIILLDVND 2082
Cdd:cd11304     81 PLS---STATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 490-603 3.43e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 116.64  E-value: 3.43e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  490 VYRVNISEEVPLGSYVRGLTATDRDSGLNANLRYSIVSGNELGWFHISEHSGLVttagpgggtaghaggaSVTSGLDRET 569
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEI----------------TTAKPLDREE 64

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2024404317  570 TSQVVLNISARDQGVQPKFSYAQLVVTILDINDN 603
Cdd:cd11304     65 QSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1881-1976 1.30e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 115.10  E-value: 1.30e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1881 VYSFDIPEDATPGSLVAAILATDDDSGINGEITYTVSEDDEEGMFFLNPVTGVFNLTRALDYEAQQYYILTIRAEDGGG- 1959
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                           90
                   ....*....|....*...
gi 2024404317 1960 -QFATIRVYFNILDINDN 1976
Cdd:cd11304     81 pLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2730-2809 1.91e-29

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 113.98  E-value: 1.91e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  2730 AVDRDSGLNGQLIYEIIEGNTENSFSINRATGEIRSVRPLDREKLSRYTLTIKASDKGTPLQSTTVKVIINVLDENDNAP 2809
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
2195-2285 3.05e-28

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 110.85  E-value: 3.05e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2195 YRVELEENTLTGTDLIQVLATDGDEGTNGQVRYSIVSGDTGNQFRIDSVTGVITVAKPLDREKKPSYMLTVQSSDRGSSP 2274
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 2024404317 2275 RTDTTTVNIVL 2285
Cdd:pfam00028   81 LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2214-2293 4.72e-28

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 110.13  E-value: 4.72e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  2214 ATDGDEGTNGQVRYSIVSGDTGNQFRIDSVTGVITVAKPLDREKKPSYMLTVQSSDRGSSPRTDTTTVNIVLKDVNDYVP 2293
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1374-1454 4.82e-27

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 107.05  E-value: 4.82e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  1374 TATDSDSGDNADLHYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIYVRDFNDNP 1453
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024404317  1454 P 1454
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3150-3230 6.98e-27

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 106.66  E-value: 6.98e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  3150 SARDRDAAMNGLIRYNISSGNEAGNFAINTTTGTLTLAKPLDFELCQKHELIVTATDGGWVSRTGFCSVTINVIDVNDNS 3229
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024404317  3230 P 3230
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3237-3331 2.25e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 2.25e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3237 YFPNVLENAPSGTTVIRLNASDADSGPNAVIAYAIQSSDSD-LFVIDPNTGTITTQGFLDYETKQSYHLTIKAFNVPDEE 3315
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*.
gi 2024404317 3316 RCSFASVNIQLEGTNE 3331
Cdd:cd11304     82 LSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1269-1349 3.06e-26

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 104.74  E-value: 3.06e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  1269 SASDVDEGTNGLIHYSVIKGNEEKQFAIDSSTGQVTLVGKLDHEATASYSLVIQAVDSGAVSLSSTCTLSIDVLDENDNS 1348
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024404317  1349 P 1349
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2814-2906 3.11e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.47  E-value: 3.11e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2814 IFSASVPENAPLGFTVTRVTTSDEDIGMNAISRYSIR--DTSLPFVINPSTGDITVSRLLNREDTDRYRIRVSAHDSG-- 2889
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGgp 80

                           90
                   ....*....|....*...
gi 2024404317 2890 -WTVSTDVTVFVTDVNDN 2906
Cdd:cd11304     81 pLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1783-1873 3.74e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.47  E-value: 3.74e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1783 LTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDS-FHVDPESGDLIATKRLDRERRSKYSLLVRADDG---LQS 1858
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggpPLS 83

                           90
                   ....*....|....*
gi 2024404317 1859 SDMRINITVSDVNDH 1873
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2712-2802 3.71e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 102.38  E-value: 3.71e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2712 FIAEIVENLSP-RKLLTVAAVDRDSGLNGQLIYEIIEGNTENSFSINRATGEIRSVRPLDREKLSRYTLTIKASDKGTPL 2790
Cdd:pfam00028    1 YSASVPENAPVgTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 2024404317 2791 QSTTVKVIINVL 2802
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3552-3648 3.89e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.39  E-value: 3.89e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3552 QGEVMENNRAGTLVMTLQSSDPDLPPNqGPFTYYLLStGPATSYFSL-STAGVLTTTREIDREQISDFYLSVITRDSGIP 3630
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGEN-GEVTYSIVS-GNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024404317 3631 QMSSTGTVQIKVIDQNDN 3648
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1357-1446 4.64e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 101.99  E-value: 4.64e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1357 SVDVLENMRVGELVSSVTATDSDSGDNADLHYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPR 1436
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|
gi 2024404317 1437 SSTMSVVIYV 1446
Cdd:pfam00028   82 SSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 935-1028 7.60e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.62  E-value: 7.60e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  935 SVNVVENWKAGHTIFQAKALDPDEGVNGMVLYSL-KQNPKGLFSINEQTGAISLIGQLDINA-GTYQVEILASDMGVPQL 1012
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEqSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 2024404317 1013 SSTFVLTVSVHDVNDN 1028
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
3133-3223 1.18e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 100.84  E-value: 1.18e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3133 SVTIPESHSVGAVIRTVSARDRDAAMNGLIRYNISSGNEAGNFAINTTTGTLTLAKPLDFELCQKHELIVTATDGGWVSR 3212
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|.
gi 2024404317 3213 TGFCSVTINVI 3223
Cdd:pfam00028   82 SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2109-2188 3.35e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 98.96  E-value: 3.35e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  2109 QATDPDSGPNSYIEYSLLR-PLGNKFSIGTIDGEVRLIGELDREAVSNYTLTVVATDKGQPSLSSSTDVVVIVLDINDNN 2187
Cdd:smart00112    1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024404317  2188 P 2188
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
2095-2181 3.54e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 99.30  E-value: 3.54e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2095 IPENTPIDTIVFKAQATDPDSGPNSYIEYSLLR-PLGNKFSIGTIDGEVRLIGELDREAVSNYTLTVVATDKGQPSLSSS 2173
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGgGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                   ....*...
gi 2024404317 2174 TDVVVIVL 2181
Cdd:pfam00028   85 ATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1464-1561 5.36e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.31  E-value: 5.36e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1464 SIIENIPVGSSVISVTANDSDADINGQLTYAIIQQTPrGNHFRIDEVRGTIFTNAEIDREFANLFELTVKATDQAVPves 1543
Cdd:cd11304      5 SVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP--- 80

                           90
                   ....*....|....*...
gi 2024404317 1544 RRFALKNVTILVMDQNDN 1561
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 4015-4178 5.37e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 100.96  E-value: 5.37e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 4015 SYGFEELSYMEFPSMDP--NNNYIYIKFATIKRNALMLYNydnQTGERAEFLALEIIEGRLRFSYNLGSGTYKLTTTKKV 4092
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAprTRLSISFSFRTTSPNGLLLYA---GSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 4093 SDGQFHTVIARRAGMAASLTVDSCSedqepgycTVSNVAVSTDWTLDVQPNrLTVGGirsVEPILQRRGQVESHDFVGCI 4172
Cdd:cd00110     78 NDGQWHSVSVERNGRSVTLSVDGER--------VVESGSPGGSALLNLDGP-LYLGG---LPEDLKSPGLPVSPGFVGCI 145


                   ....*.
gi 2024404317 4173 MEFAVN 4178
Cdd:cd00110    146 RDLKVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3341-3438 1.30e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.15  E-value: 1.30e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3341 YYFEVSEAASEGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQIDERSGQIYVSGPLDREKEERISLKVLAKNFGSir 3420
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG-- 79

                           90
                   ....*....|....*...
gi 2024404317 3421 GADIDEVTVNITILDAND 3438
Cdd:cd11304     80 PPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2425-2502 1.52e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 97.42  E-value: 1.52e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  2425 SDADASRNAVISYRLTGGN--SQFTINPSTGQIITSALLDRETRENYTLIVVASDGGYPRaLSSSTSVLVAVADVNDNPP 2502
Cdd:smart00112    3 TDADSGENGKVTYSILSGNddGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP-LSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2914-3017 2.15e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.38  E-value: 2.15e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2914 SYYLECPELPGIGLKVTQVSATDPDEGSNGHVFYFIKSQSE--FFRINATTGEIFNKQYLRYQNssgssnvnINRHSFIV 2991
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREE--------QSSYTLTV 72

                           90       100
                   ....*....|....*....|....*.
gi 2024404317 2992 TSSDRGSPPLLSETTVTINIVDSNDN 3017
Cdd:cd11304     73 TATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2611-2703 2.28e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.38  E-value: 2.28e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2611 TFTFPENQAVGTLVTTISGSSA---RGGSLSYYIASGNLGNTFIVDQVTGQLSVGQALDFEAIQKYVVWIEARDTGFPPF 2687
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 2024404317 2688 SSYKKLEVTVVDVNDN 2703
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
242-340 2.86e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 96.99  E-value: 2.86e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  242 YQARVPEDAPVGASVLQVAAADADEGTNADIRYRLEGGDggggegaSSLPFEVDPESGVIRIRERLDYELCQQYSLTVQA 321
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGG-------PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEA 73

                           90
                   ....*....|....*....
gi 2024404317  322 TDRGVPALSGRAEALIRLL 340
Cdd:pfam00028   74 TDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3465-3546 3.64e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 96.26  E-value: 3.64e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  3465 SAFDSDSVPSWsRFSYFIGSGNDNSAFSINPQTGQVTVTAELDRETLPVYNLSVLAIDSGTPSATGSASLLVTLEDINDN 3544
Cdd:smart00112    1 SATDADSGENG-KVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 2024404317  3545 GP 3546
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 509-605 4.25e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.88  E-value: 4.25e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317   509 TATDRDSGLNANLRYSIVSGNELGWFHISEHSGLVttagpgggtaghaggaSVTSGLDRETTSQVVLNISARDQGVQPKF 588
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEI----------------TTTKPLDREEQPEYTLTVEATDGGGPPLS 64

                            90
                    ....*....|....*..
gi 2024404317   589 SYAQLVVTILDINDNKP 605
Cdd:smart00112   65 STATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
491-598 4.84e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 96.22  E-value: 4.84e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  491 YRVNISEEVPLGSYVRGLTATDRDSGLNANLRYSIVSGNELGWFHISEHSGLVttagpgggtaghaggaSVTSGLDRETT 570
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDI----------------STTKPLDRESI 64

                           90       100
                   ....*....|....*....|....*...
gi 2024404317  571 SQVVLNISARDQGVQPKFSYAQLVVTIL 598
Cdd:pfam00028   65 GEYELTVEATDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
613-716 5.71e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.83  E-value: 5.71e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  613 YQVSLAENSPSGTELLVLSAVDGDLGDNGTIRFSLqeaepavvavgpSSVTPRQVFRLDPVSGKLSTISQLDREEQAHFS 692
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI------------LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYE 68

                           90       100
                   ....*....|....*....|....
gi 2024404317  693 LQVLATDLGSPPLSSVARVNVSLL 716
Cdd:pfam00028   69 LTVEATDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
3447-3539 7.35e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.83  E-value: 7.35e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3447 YNVQISEGVPPGTHVTFVSAFDSDSVPSWsRFSYFIGSGNDNSAFSINPQTGQVTVTAELDRETLPVYNLSVLAIDSGTP 3526
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNG-RIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 2024404317 3527 SATGSASLLVTLE 3539
Cdd:pfam00028   80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1251-1342 9.10e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.45  E-value: 9.10e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1251 YQATISELAANLTQVLRVSASDVDEGTNGLIHYSVIKGNEEKQFAIDSSTGQVTLVGKLDHEATASYSLVIQAVDSGAVS 1330
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 2024404317 1331 LSSTCTLSIDVL 1342
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1141-1242 2.22e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.69  E-value: 2.22e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1141 YVFYFEEEQSGGSYVGKINAVDKDFGPNGEVRYSF--EHMQPDFELNTITGEIRSTHQFDREALmrqrgaAVFSLTVIAT 1218
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQ------SSYTLTVTAT 75

                           90       100
                   ....*....|....*....|....
gi 2024404317 1219 DQGLPkPLKDQATVQIYMKDINDN 1242
Cdd:cd11304     76 DGGGP-PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
730-820 2.41e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 94.29  E-value: 2.41e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  730 YFAHIQENEPAGTYVTTVSATDPDMGPNGTVKYSISAGDTSR-FQVHGKTGIITTKIALDREEKTAYQLQIVATDGGHLQ 808
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 2024404317  809 SQNQAIVTITVL 820
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 126-233 3.15e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 3.15e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  126 SIVVTFKEDTGSGRQLILDTATDADSGTNGvdHSSYRIVSGNEEGRFRLNITlnpSGEgaflhLVSQGGLDREATPSYQL 205
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSIDPS---TGE-----ITTAKPLDREEQSSYTL 70

                           90       100
                   ....*....|....*....|....*...
gi 2024404317  206 LVQVEDKGEPRRRGYLQVNVTVQDINDN 233
Cdd:cd11304     71 TVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2299-2396 4.60e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.53  E-value: 4.60e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2299 PYNVNVPENLEtLPKVILQVVARDDDQGLNSKLTYVLVSGNEEGAFIL-SASGELRLVQSLDRERKEQYVLLITAADSGS 2377
Cdd:cd11304      1 SYEVSVPENAP-PGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 2024404317 2378 PALTGTGTITVTVDDVNDN 2396
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2405-2494 4.90e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 93.52  E-value: 4.90e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2405 YSATVPEDAPTGTDILLVNSSDADASRNAVISYRLTGGNS--QFTINPSTGQIITSALLDRETRENYTLIVVASDGGYPr 2482
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPggNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP- 79

                           90
                   ....*....|..
gi 2024404317 2483 ALSSSTSVLVAV 2494
Cdd:pfam00028   80 PLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 834-925 5.75e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.53  E-value: 5.75e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  834 YGFVVFENVALGYHVGTVFASTMDLNTN--ISYLITTGDQRGMFAINKVTGQITTASIIDREEQAFYQLKVVASGGAV-- 909
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 2024404317  910 -TGDTIVNITVKDLNDN 925
Cdd:cd11304     82 lSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 631-723 6.67e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.41  E-value: 6.67e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317   631 SAVDGDLGDNGTIRFSLqeaepavvavgpSSVTPRQVFRLDPVSGKLSTISQLDREEQAHFSLQVLATDLGSPPLSSVAR 710
Cdd:smart00112    1 SATDADSGENGKVTYSI------------LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTAT 68

                            90
                    ....*....|...
gi 2024404317   711 VNVSLLDVNDNSP 723
Cdd:smart00112   69 VTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 261-347 7.00e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.41  E-value: 7.00e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317   261 AADADEGTNADIRYRLEGGDGgggegasSLPFEVDPESGVIRIRERLDYELCQQYSLTVQATDRGVPALSGRAEALIRLL 340
Cdd:smart00112    2 ATDADSGENGKVTYSILSGND-------DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                    ....*..
gi 2024404317   341 DVNDNEP 347
Cdd:smart00112   75 DVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2003-2085 8.84e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.03  E-value: 8.84e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  2003 SVTDADDGSNSQLSFSIASGDSMGHFGID-NSGVLSTQQPLDRESQSFYSLVVQVHDMAPLPASrytSTAQVSIILLDVN 2081
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDpETGEITTTKPLDREEQPEYTLTVEATDGGGPPLS---STATVTITVLDVN 77


                    ....
gi 2024404317  2082 DSPP 2085
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1055-1134 8.84e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.03  E-value: 8.84e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  1055 HATDKDSGVNGEIAYSIIEGNAGDAFGIFPD-GQLYIKSELDRELQERYILLVVASDRAVEPLNATVNITVILEDVNDNR 1133
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024404317  1134 P 1134
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
1985-2078 1.21e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 92.36  E-value: 1.21e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1985 YSTSLMENLAPGSAILNFSVTDADDGSNSQLSFSIASGDSMGHFGID-NSGVLSTQQPLDRESQSFYSLVVQVHDMAPLP 2063
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDpDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|....*
gi 2024404317 2064 ASrytSTAQVSIILL 2078
Cdd:pfam00028   81 LS---STATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 748-827 1.34e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 91.64  E-value: 1.34e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317   748 SATDPDMGPNGTVKYSISAGDTSR-FQVHGKTGIITTKIALDREEKTAYQLQIVATDGGHLQSQNQAIVTITVLDTQDNP 826
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGlFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024404317   827 P 827
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
1037-1125 1.68e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 91.98  E-value: 1.68e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1037 YEITILESEPVNSRFFKVHATDKDSGVNGEIAYSIIEGNAGDAFGIFPD-GQLYIKSELDRELQERYILLVVASDRAVEP 1115
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 2024404317 1116 L--NATVNITVI 1125
Cdd:pfam00028   81 LssTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1901-1978 2.53e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.87  E-value: 2.53e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  1901 ATDDDSGINGEITYTVSEDDEEGMFFLNPVTGVFNLTRALDYEAQQYYILTIRAEDGGGQ--FATIRVYFNILDINDNPP 1978
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPplSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
1882-1971 3.02e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 91.21  E-value: 3.02e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1882 YSFDIPEDATPGSLVAAILATDDDSGINGEITYTVSEDDEEGMFFLNPVTGVFNLTRALDYEAQQYYILTIRAEDGG--G 1959
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgpP 80

                           90
                   ....*....|..
gi 2024404317 1960 QFATIRVYFNIL 1971
Cdd:pfam00028   81 LSSTATVTITVL 92
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 4288-4411 1.41e-20

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 90.56  E-value: 1.41e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 4288 FRTRSENGILFHI-QESSNFTTVKIRAGKVHYISDAGiAGKVERNIPEVYTADGQWHSVRIEKNGSTTVLSVDKTHKRDI 4366
Cdd:pfam02210    1 FRTRQPNGLLLYAgGGGSDFLALELVNGRLVLRYDLG-SGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 2024404317 4367 lHVTQDFGGLNVLT-ISLGGIPPNQPFKSTV--AGFDGCISYIKYGGE 4411
Cdd:pfam02210   80 -LPPGESLLLNLNGpLYLGGLPPLLLLPALPvrAGFVGCIRDVRVNGE 126
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1799-1875 1.84e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.56  E-value: 1.84e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  1799 TAMDADEGANALVTYTIISGADDS-FHVDPESGDLIATKRLDRERRSKYSLLVRADDG---LQSSDMRINITVSDVNDHI 1874
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGlFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVNDNA 80


                    .
gi 2024404317  1875 P 1875
Cdd:smart00112   81 P 81
LamG smart00282
Laminin G domain;
4283-4411 2.64e-20

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 89.71  E-value: 2.64e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  4283 SLEVKFRTRSENGILFHIQES--SNFTTVKIRAGKVHYISDAGIAGKVERNIPEVYtADGQWHSVRIEKNGSTTVLSVDK 4360
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKggGDYLALELRDGRLVLRYDLGSGPARLTSDPTPL-NDGQWHRVAVERNGRSVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2024404317  4361 THKRDIlHVTQDFGGLNVLT-ISLGGIPPNQ--PFKSTVAGFDGCISYIKYGGE 4411
Cdd:smart00282   80 GNRVSG-ESPGGLTILNLDGpLYLGGLPEDLklPPLPVTPGFRGCIRNLKVNGK 132
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3026-3121 3.25e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.52  E-value: 3.25e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3026 YFTPVTKNVRAGTNLIKVTAVDdKDFGLNSEVEYFVSDESKTNKFRLDRSTGWISVSSSLMADLNKKFLFKVKAKDKGNP 3105
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATD-PDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*.
gi 2024404317 3106 PLSSEVAVEIVVTEEN 3121
Cdd:cd11304     81 PLSSTATVTITVLDVN 96
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 360-482 3.62e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.14  E-value: 3.62e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  360 FASVDENAAPGTVVALLTVSDADSPaANGNISVSILAGNEQRHFEVHsskvPNLSLIKVAAALDRERIPAYNLTVAVADn 439
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSG-ENGEVTYSIVSGNEDGLFSID----PSTGEITTAKPLDREEQSSYTLTVTATD- 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2024404317  440 yGASPPppgfptsslspdgvaatpvsRSSVASLVIFVNDINDH 482
Cdd:cd11304     77 -GGGPP--------------------LSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
3241-3327 5.17e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.74  E-value: 5.17e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3241 VLENAPSGTTVIRLNASDADSGPNAVIAYAIQSSDSD-LFVIDPNTGTITTQGFLDYETKQSYHLTIKAFNVPDEERCSF 3319
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                   ....*...
gi 2024404317 3320 ASVNIQLE 3327
Cdd:pfam00028   85 ATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 145-235 6.79e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.02  E-value: 6.79e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317   145 TATDADSGTNGvdHSSYRIVSGNEEGRFRLNITlnpSGEgaflhLVSQGGLDREATPSYQLLVQVEDKGEPRRRGYLQVN 224
Cdd:smart00112    1 SATDADSGENG--KVTYSILSGNDDGLFSIDPE---TGE-----ITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVT 70

                            90
                    ....*....|.
gi 2024404317   225 VTVQDINDNPP 235
Cdd:smart00112   71 ITVLDVNDNAP 81
LamG smart00282
Laminin G domain;
4035-4180 7.82e-20

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 88.55  E-value: 7.82e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  4035 YIYIKFATIKRNALMLYNYDNQTGEraeFLALEIIEGRLRFSYNLGSGTYKLT-TTKKVSDGQFHTVIARRAGMAASLTV 4113
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGD---YLALELRDGRLVLRYDLGSGPARLTsDPTPLNDGQWHRVAVERNGRSVTLSV 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024404317  4114 DSCSEdqepgyctVSNVAVSTDWTLDVqPNRLTVGGirsVEPILQRRGQVESHDFVGCIMEFAVNGR 4180
Cdd:smart00282   78 DGGNR--------VSGESPGGLTILNL-DGPLYLGG---LPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 952-1030 8.92e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 86.63  E-value: 8.92e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317   952 KALDPDEGVNGMVLYSLKQ-NPKGLFSINEQTGAISLIGQLD-INAGTYQVEILASDMGVPQLSSTFVLTVSVHDVNDNP 1029
Cdd:smart00112    1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDrEEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024404317  1030 P 1030
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
3551-3643 1.63e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.20  E-value: 1.63e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3551 RQGEVMENNRAGTLVMTLQSSDPDLPPNQGPFtyYLLSTGPATSYFSLSTA-GVLTTTREIDREQISDFYLSVITRDSGI 3629
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIF--YSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 2024404317 3630 PQMSSTGTVQIKVI 3643
Cdd:pfam00028   79 PPLSSTATVTITVL 92
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 4275-4404 1.75e-19

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 88.24  E-value: 1.75e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 4275 SPGPLNVDSLEVKFRTRSENGILFHI--QESSNFTTVKIRAGKVHYISDAGIAGKVERNIPEVytADGQWHSVRIEKNGS 4352
Cdd:cd00110     15 LPAPRTRLSISFSFRTTSPNGLLLYAgsQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPL--NDGQWHSVSVERNGR 92

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2024404317 4353 TTVLSVDKTHKRDILHVTQDFGGLNVLTISLGGIPPN--QPFKSTVAGFDGCIS 4404
Cdd:cd00110     93 SVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDlkSPGLPVSPGFVGCIR 146
Cadherin pfam00028
Cadherin domain;
1784-1867 6.87e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 84.27  E-value: 6.87e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1784 TVEENIGDGSKIMQLTAMDADEGANALVTYTIISG-ADDSFHVDPESGDLIATKRLDRERRSKYSLLVRADDGL---QSS 1859
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgppLSS 83


                   ....*...
gi 2024404317 1860 DMRINITV 1867
Cdd:pfam00028   84 TATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2933-3019 1.30e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.17  E-value: 1.30e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  2933 SATDPDEGSNGHVFYFIKSQSE--FFRINATTGEIFNKQYLRYQNssgssnvnINRHSFIVTSSDRGSPPLLSETTVTIN 3010
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDdgLFSIDPETGEITTTKPLDREE--------QPEYTLTVEATDGGGPPLSSTATVTIT 72


                    ....*....
gi 2024404317  3011 IVDSNDNAP 3019
Cdd:smart00112   73 VLDVNDNAP 81
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 4040-4180 2.04e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 84.39  E-value: 2.04e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 4040 FATIKRNALMLYNydnqTGERAEFLALEIIEGRLRFSYNLGSGTYKLT-TTKKVSDGQFHTVIARRAGMAASLTVDSCSe 4118
Cdd:pfam02210    1 FRTRQPNGLLLYA----GGGGSDFLALELVNGRLVLRYDLGSGPESLLsSGKNLNDGQWHSVRVERNGNTLTLSVDGQT- 75

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024404317 4119 dqepgyctvSNVAVSTDWTLDVQPNR-LTVGGIRSVEPIlqrRGQVESHDFVGCIMEFAVNGR 4180
Cdd:pfam02210   76 ---------VVSSLPPGESLLLNLNGpLYLGGLPPLLLL---PALPVRAGFVGCIRDVRVNGE 126
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2635-2705 5.64e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.24  E-value: 5.64e-18
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024404317  2635 GSLSYYIASGNLGNTFIVDQVTGQLSVGQALDFEAIQKYVVWIEARDTGFPPFSSYKKLEVTVVDVNDNAP 2705
Cdd:smart00112   11 GKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1159-1244 9.19e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.86  E-value: 9.19e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  1159 NAVDKDFGPNGEVRYSF--EHMQPDFELNTITGEIRSTHQFDREALmrqrgaAVFSLTVIATDQGLPkPLKDQATVQIYM 1236
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTKPLDREEQ------PEYTLTVEATDGGGP-PLSSTATVTITV 73


                    ....*...
gi 2024404317  1237 KDINDNAP 1244
Cdd:smart00112   74 LDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2833-2908 1.15e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.47  E-value: 1.15e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  2833 TTSDEDIGMNAISRYSI--RDTSLPFVINPSTGDITVSRLLNREDTDRYRIRVSAHDSG---WTVSTDVTVFVTDVNDNA 2907
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGgppLSSTATVTITVLDVNDNA 80


                    .
gi 2024404317  2908 P 2908
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
1464-1540 3.61e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.65  E-value: 3.61e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024404317 1464 SIIENIPVGSSVISVTANDSDADINGQLTYAIIQQtPRGNHFRIDEVRGTIFTNAEIDREFANLFELTVKATDQAVP 1540
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG-GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79
Cadherin pfam00028
Cadherin domain;
2611-2697 4.79e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.27  E-value: 4.79e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2611 TFTFPENQAVGTLVTTISGS---SARGGSLSYYIASGNLGNTFIVDQVTGQLSVGQALDFEAIQKYVVWIEARDTGFPPF 2687
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATdpdLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|
gi 2024404317 2688 SSYKKLEVTV 2697
Cdd:pfam00028   82 SSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1479-1563 5.05e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.55  E-value: 5.05e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  1479 TANDSDADINGQLTYAIIQQTPrGNHFRIDEVRGTIFTNAEIDREFANLFELTVKATDQAVPvesRRFALKNVTILVMDQ 1558
Cdd:smart00112    1 SATDADSGENGKVTYSILSGND-DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP---PLSSTATVTITVLDV 76


                    ....*
gi 2024404317  1559 NDNVP 1563
Cdd:smart00112   77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3571-3649 2.29e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.62  E-value: 2.29e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  3571 SDPDLPPNqGPFTYYLLStGPATSYFSL-STAGVLTTTREIDREQISDFYLSVITRDSGIPQMSSTGTVQIKVIDQNDNP 3649
Cdd:smart00112    3 TDADSGEN-GKVTYSILS-GNDDGLFSIdPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3900-3936 2.30e-16

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 75.37  E-value: 2.30e-16
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2024404317 3900 DIDECL-PSPCHNDGTCHNLVGGFSCSCPDGFTGMACE 3936
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3255-3334 2.89e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.62  E-value: 2.89e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  3255 NASDADSGPNAVIAYAI-QSSDSDLFVIDPNTGTITTQGFLDYETKQSYHLTIKAFNVPDEERCSFASVNIQLEGTNEYV 3333
Cdd:smart00112    1 SATDADSGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024404317  3334 P 3334
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3360-3440 3.58e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.23  E-value: 3.58e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  3360 ASDRDLGTDGEVHYLIFGNSRKKGFQIDERSGQIYVSGPLDREKEERISLKVLAKNFGSIRgaDIDEVTVNITILDANDP 3439
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP--LSSTATVTITVLDVNDN 79


                    .
gi 2024404317  3440 P 3440
Cdd:smart00112   80 A 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 859-927 8.36e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.08  E-value: 8.36e-16
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024404317   859 NTNISYLITTGDQRGMFAINKVTGQITTASIIDREEQAFYQLKVVASGGAV---TGDTIVNITVKDLNDNSP 927
Cdd:smart00112   10 NGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGpplSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1579-1661 9.60e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 9.60e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1579 IGSILTTIIAADPDEGANGEVEYEIINGDT-KTFIVDRYSGDLRVASAL-VPSQLIYNLIVSATDLGPERRKSTTEMTII 1656
Cdd:cd11304     12 PGTVVLTVSATDPDSGENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLdREEQSSYTLTVTATDGGGPPLSSTATVTIT 91


                   ....*
gi 2024404317 1657 LQGVD 1661
Cdd:cd11304     92 VLDVN 96
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2508-2595 9.88e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.43  E-value: 9.88e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2508 PYVTHVPSPTTSGSFVFAVTVTDADAGSNAELHYSLMGKNA-EKFHIDSARGAILAANELSGE--SEVTISVHVRDGGRY 2584
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDREeqSSYTLTVTATDGGGP 80

                           90
                   ....*....|.
gi 2024404317 2585 PKTDSTTVTVR 2595
Cdd:cd11304     81 PLSSTATVTIT 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1670-1772 2.13e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 74.66  E-value: 2.13e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1670 YITILKEGEPIGTNVISIEASSP-RGSEAQVEYYIVSvrcedKSLGRLFTIGRHTGVIQTAAILDREQgVRLYLVDVYAI 1748
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPdSGENGEVTYSIVS-----GNEDGLFSIDPSTGEITTAKPLDREE-QSSYTLTVTAT 75

                           90       100
                   ....*....|....*....|....
gi 2024404317 1749 EkSSVLPRTQRAEVEITLQDINDN 1772
Cdd:cd11304     76 D-GGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2815-2901 2.47e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 2.47e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2815 FSASVPENAPLGFTVTRVTTSDEDIGMNAISRYSIR--DTSLPFVINPSTGDITVSRLLNREDTDRYRIRVSAHDSG--- 2889
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgpp 80

                           90
                   ....*....|..
gi 2024404317 2890 WTVSTDVTVFVT 2901
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
3341-3434 2.75e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 2.75e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3341 YYFEVSEAASEGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQIDERSGQIYVSGPLDREKEERISLKVLAKNfGSIR 3420
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD-SGGP 79

                           90
                   ....*....|....
gi 2024404317 3421 GADiDEVTVNITIL 3434
Cdd:pfam00028   80 PLS-STATVTITVL 92
EGF_CA smart00179
Calcium-binding EGF-like domain;
3900-3936 3.90e-15

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 71.89  E-value: 3.90e-15
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2024404317  3900 DIDECL-PSPCHNDGTCHNLVGGFSCSCPDGFT-GMACE 3936
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2319-2398 3.97e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.15  E-value: 3.97e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  2319 VARDDDQGLNSKLTYVLVSGNEEGAF-ILSASGELRLVQSLDRERKEQYVLLITAADSGSPALTGTGTITVTVDDVNDNV 2397
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFsIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024404317  2398 P 2398
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
834-919 4.34e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.49  E-value: 4.34e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  834 YGFVVFENVALGYHVGTVFASTMDL--NTNISYLITTGDQRGMFAINKVTGQITTASIIDREEQAFYQLKVVAS---GGA 908
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLgpNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATdsgGPP 80

                           90
                   ....*....|.
gi 2024404317  909 VTGDTIVNITV 919
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
2300-2380 4.74e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.49  E-value: 4.74e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2300 YNVNVPENLETLPKViLQVVARDDDQGLNSKLTYVLVSGNEEGAFIL-SASGELRLVQSLDRERKEQYVLLITAADSGSP 2378
Cdd:pfam00028    1 YSASVPENAPVGTEV-LTVTATDPDLGPNGRIFYSILGGGPGGNFRIdPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79


                   ..
gi 2024404317 2379 AL 2380
Cdd:pfam00028   80 PL 81
Cadherin pfam00028
Cadherin domain;
2915-3011 4.74e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.49  E-value: 4.74e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2915 YYLECPELPGIGLKVTQVSATDPDEGSNGHVFYFIKSQSE--FFRINATTGEIFNKQYLRYQnssgssnvNINRHSFIVT 2992
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPggNFRIDPDTGDISTTKPLDRE--------SIGEYELTVE 72

                           90
                   ....*....|....*....
gi 2024404317 2993 SSDRGSPPLLSETTVTINI 3011
Cdd:pfam00028   73 ATDSGGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
935-1023 6.47e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.10  E-value: 6.47e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  935 SVNVVENWKAGHTIFQAKALDPDEGVNGMVLYS-LKQNPKGLFSINEQTGAISLIGQLDINA-GTYQVEILASDMGVPQL 1012
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRESiGEYELTVEATDSGGPPL 81

                           90
                   ....*....|.
gi 2024404317 1013 SSTFVLTVSVH 1023
Cdd:pfam00028   82 SSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
361-446 9.19e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 72.72  E-value: 9.19e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  361 ASVDENAAPGTVVALLTVSDADSPaANGNISVSILAGNEQRHFEVHsskvPNLSLIKVAAALDRERIPAYNLTVAVADNy 440
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLG-PNGRIFYSILGGGPGGNFRID----PDTGDISTTKPLDRESIGEYELTVEATDS- 76


                   ....*.
gi 2024404317  441 gASPPP 446
Cdd:pfam00028   77 -GGPPL 81
Cadherin pfam00028
Cadherin domain;
1141-1234 7.18e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.02  E-value: 7.18e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1141 YVFYFEEEQSGGSYVGKINAVDKDFGPNGEVRYSF--EHMQPDFELNTITGEIRSTHQFDREALmrqrgaAVFSLTVIAT 1218
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIDPDTGDISTTKPLDRESI------GEYELTVEAT 74

                           90
                   ....*....|....*.
gi 2024404317 1219 DQGLPkPLKDQATVQI 1234
Cdd:pfam00028   75 DSGGP-PLSSTATVTI 89
Cadherin pfam00028
Cadherin domain;
127-228 1.41e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 1.41e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  127 IVVTFKEDTGSGRQLILDTATDADSGTNGVDhsSYRIVSGNEEGRFRLNITlnpSGEgaflhLVSQGGLDREATPSYQLL 206
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRI--FYSILGGGPGGNFRIDPD---TGD-----ISTTKPLDRESIGEYELT 70

                           90       100
                   ....*....|....*....|..
gi 2024404317  207 VQVEDKGEPRRRGYLQVNVTVQ 228
Cdd:pfam00028   71 VEATDSGGPPLSSTATVTITVL 92
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3938-3973 1.51e-13

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 67.28  E-value: 1.51e-13
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2024404317 3938 DVNECLS-NPCKNGAACQNFPGTFNCICKTGYTGKTC 3973
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3048-3125 1.65e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 1.65e-13
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2024404317  3048 DKDFGLNSEVEYFVSDESKTNKFRLDRSTGWISVSSSLMADLNKKFLFKVKAKDKGNPPLSSEVAVEIVVTEENYHTP 3125
Cdd:smart00112    4 DADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 377-484 4.36e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.37  E-value: 4.36e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317   377 TVSDADSPAaNGNISVSILAGNEQRHFEVHsskvPNLSLIKVAAALDRERIPAYNLTVAVADnyGASPPppgfptsslsp 456
Cdd:smart00112    1 SATDADSGE-NGKVTYSILSGNDDGLFSID----PETGEITTTKPLDREEQPEYTLTVEATD--GGGPP----------- 62

                            90       100
                    ....*....|....*....|....*...
gi 2024404317   457 dgvaatpvsRSSVASLVIFVNDINDHPP 484
Cdd:smart00112   63 ---------LSSTATVTITVLDVNDNAP 81
EGF_CA smart00179
Calcium-binding EGF-like domain;
3938-3974 2.70e-12

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 63.81  E-value: 2.70e-12
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2024404317  3938 DVNECLS-NPCKNGAACQNFPGTFNCICKTGYT-GKTCD 3974
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
Cadherin pfam00028
Cadherin domain;
1579-1658 1.01e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.86  E-value: 1.01e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1579 IGSILTTIIAADPDEGANGEVEYEIINGDTK-TFIVDRYSGDLRVASAL-VPSQLIYNLIVSATDLGPERRKSTTEMTII 1656
Cdd:pfam00028   11 VGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTTKPLdRESIGEYELTVEATDSGGPPLSSTATVTIT 90


                   ..
gi 2024404317 1657 LQ 1658
Cdd:pfam00028   91 VL 92
Cadherin pfam00028
Cadherin domain;
3026-3118 1.36e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.47  E-value: 1.36e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3026 YFTPVTKNVRAGTNLIKVTAVDdKDFGLNSEVEYFVSDESKTNKFRLDRSTGWISVSSSLMADLNKKFLFKVKAKDKGNP 3105
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATD-PDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 2024404317 3106 PLSSEVAVEIVVT 3118
Cdd:pfam00028   80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1588-1661 8.81e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.83  E-value: 8.81e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024404317  1588 AADPDEGANGEVEYEIINGDTKT-FIVDRYSGDLRVASAL-VPSQLIYNLIVSATDLGPERRKSTTEMTIILQGVD 1661
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGlFSIDPETGEITTTKPLdREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1693-1774 2.34e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 59.67  E-value: 2.34e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  1693 RGSEAQVEYYIVSvrcedKSLGRLFTIGRHTGVIQTAAILDREQGVRlYLVDVYAIEKSSVlPRTQRAEVEITLQDINDN 1772
Cdd:smart00112    7 SGENGKVTYSILS-----GNDDGLFSIDPETGEITTTKPLDREEQPE-YTLTVEATDGGGP-PLSSTATVTITVLDVNDN 79


                    ..
gi 2024404317  1773 PP 1774
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
2509-2594 3.29e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 59.62  E-value: 3.29e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2509 YVTHVPSPTTSGSFVFAVTVTDADAGSNAELHYSLMGKNAE-KFHIDSARGAILAANELSGE--SEVTISVHVRDGGRYP 2585
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTTKPLDREsiGEYELTVEATDSGGPP 80


                   ....*....
gi 2024404317 2586 KTDSTTVTV 2594
Cdd:pfam00028   81 LSSTATVTI 89
EGF_CA pfam07645
Calcium-binding EGF domain;
3900-3929 1.17e-09

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 56.09  E-value: 1.17e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2024404317 3900 DIDECL--PSPCHNDGTCHNLVGGFSCSCPDG 3929
Cdd:pfam07645    1 DVDECAtgTHNCPANTVCVNTIGSFECRCPDG 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 3942-3972 1.31e-09

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 56.24  E-value: 1.31e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2024404317 3942 CLSNPCKNGAACQNFPGTFNCICKTGYTGKT 3972
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 35-118 2.03e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 57.71  E-value: 2.03e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317   35 VFQVLEEQPAGTWVGTI-AT------RPGFTYRLSEHHA--LFSINATSGALHTRASIDRESLASdvVDLVVL-----SS 100
Cdd:cd11304      3 EVSVPENAPPGTVVLTVsATdpdsgeNGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSS--YTLTVTatdggGP 80

                           90
                   ....*....|....*...
gi 2024404317  101 QPTYPSEVRVLVLDLNDN 118
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1670-1767 1.79e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 54.61  E-value: 1.79e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1670 YITILKEGEPIGTNVISIEASSP-RGSEAQVEYYIVSvrcedKSLGRLFTIGRHTGVIQTAAILDREQgVRLYLVDVYAI 1748
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPdLGPNGRIFYSILG-----GGPGGNFRIDPDTGDISTTKPLDRES-IGEYELTVEAT 74

                           90
                   ....*....|....*....
gi 2024404317 1749 EKSSVlPRTQRAEVEITLQ 1767
Cdd:pfam00028   75 DSGGP-PLSSTATVTITVL 92
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4467-4500 2.76e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.64  E-value: 2.76e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2024404317 4467 CAS-SPCQNGGSCEPGPqASFTCSCPESYVGQRCE 4500
Cdd:cd00054      5 CASgNPCQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3977-4012 2.10e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 2.10e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2024404317 3977 VNYCE-CNPCFNGGSCQSGLEGYYCHCPFGVFGNHCE 4012
Cdd:cd00054      2 IDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 57-120 5.58e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.04  E-value: 5.58e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024404317    57 FTYRLS--EHHALFSINATSGALHTRASIDRESLasDVVDLVVL-----SSQPTYPSEVRVLVLDLNDNAP 120
Cdd:smart00112   13 VTYSILsgNDDGLFSIDPETGEITTTKPLDREEQ--PEYTLTVEatdggGPPLSSTATVTITVLDVNDNAP 81
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4204-4236 1.55e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 1.55e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2024404317 4204 CTT-SPCQHGGTCTDHWSWQQCQCKDGLTGDHCE 4236
Cdd:cd00054      5 CASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
3977-4012 2.56e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 2.56e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 2024404317  3977 VNYCE-CNPCFNGGSCQSGLEGYYCHCPFG-VFGNHCE 4012
Cdd:smart00179    2 IDECAsGNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 3980-4010 2.67e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 46.61  E-value: 2.67e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2024404317 3980 CECNPCFNGGSCQSGLEGYYCHCPFGVFGNH 4010
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
4467-4500 2.91e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 2.91e-06
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2024404317  4467 CAS-SPCQNGGSCEPGPqASFTCSCPESYV-GQRCE 4500
Cdd:smart00179    5 CASgNPCQNGGTCVNTV-GSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 4467-4498 5.35e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 45.84  E-value: 5.35e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2024404317 4467 CASSPCQNGGSCEPGPQaSFTCSCPESYVGQR 4498
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPG-GYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 4204-4234 3.48e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.53  E-value: 3.48e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2024404317 4204 CTTSPCQHGGTCTDHWSWQQCQCKDGLTGDH 4234
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 2470-2639 2.12e-04

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 48.11  E-value: 2.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2470 TLIVVASDGgyprALSSSTSVLVAVADVNdnppkfqHHPYVTHVPSPTT-SGSFV-FAVTVTDADAGSNAELHYSLMGKN 2547
Cdd:NF038112  1349 TFTLTVSDG----TASATDTVTVTVRNVN-------RAPVANAGADQTVdERSTVtLSGSATDPDGDALTYAWTQTAGPT 1417

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2548 AEKFHIDSARgAILAANELSGESEVTISVHVRDGGRYPKTDSTTVTVRFVNRAefPQVQAeQETFTFPENQAVgTLVTti 2627
Cdd:NF038112  1418 VTLTGADTAT-ASFTAPEVAADTELTFQLTVSADGQASADVTVTVTVRNVNRA--PVAHA-GESITVDEGSTV-TLDA-- 1490

                          170
                   ....*....|..
gi 2024404317 2628 SGSSARGGSLSY 2639
Cdd:NF038112  1491 SATDPDGDTLTY 1502
EGF_CA smart00179
Calcium-binding EGF-like domain;
4204-4236 2.53e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 2.53e-04
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 2024404317  4204 CTT-SPCQHGGTCTDHWSWQQCQCKDGLT-GDHCE 4236
Cdd:smart00179    5 CASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
Cadherin pfam00028
Cadherin domain;
34-113 1.07e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 41.13  E-value: 1.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317   34 QVFQVLEEQPAGTWVGTIATRP-------GFTYRLSEHHA--LFSINATSGALHTRASIDRESLASDVVDLVVLSSQP-- 102
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDpdlgpngRIFYSILGGGPggNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGpp 80

                           90
                   ....*....|..
gi 2024404317  103 -TYPSEVRVLVL 113
Cdd:pfam00028   81 lSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2195-2290 1.85e-36

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 134.75  E-value: 1.85e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2195 YRVELEENTLTGTDLIQVLATDGDEGTNGQVRYSIVSGDTGNQFRIDSVTGVITVAKPLDREKKPSYMLTVQSSDRGSSP 2274
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*.
gi 2024404317 2275 RTDTTTVNIVLKDVND 2290
Cdd:cd11304     82 LSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3131-3228 1.66e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 126.27  E-value: 1.66e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3131 HMSVTIPESHSVGAVIRTVSARDRDAAMNGLIRYNISSGNEAGNFAINTTTGTLTLAKPLDFELCQKHELIVTATDGGWV 3210
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024404317 3211 SRTGFCSVTINVIDVNDN 3228
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1357-1452 1.85e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 126.27  E-value: 1.85e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1357 SVDVLENMRVGELVSSVTATDSDSGDNADLHYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPR 1436
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 2024404317 1437 SSTMSVVIYVRDFNDN 1452
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3446-3544 5.80e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 124.73  E-value: 5.80e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3446 TYNVQISEGVPPGTHVTFVSAFDSDSvPSWSRFSYFIGSGNDNSAFSINPQTGQVTVTAELDRETLPVYNLSVLAIDSGT 3525
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDS-GENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 2024404317 3526 PSATGSASLLVTLEDINDN 3544
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1251-1347 6.39e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 124.73  E-value: 6.39e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1251 YQATISELAANLTQVLRVSASDVDEGTNGLIHYSVIKGNEEKQFAIDSSTGQVTLVGKLDHEATASYSLVIQAVDSGAVS 1330
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*..
gi 2024404317 1331 LSSTCTLSIDVLDENDN 1347
Cdd:cd11304     82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2711-2807 1.27e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.58  E-value: 1.27e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2711 PFIAEIVENLSP-RKLLTVAAVDRDSGLNGQLIYEIIEGNTENSFSINRATGEIRSVRPLDREKLSRYTLTIKASDKGTP 2789
Cdd:cd11304      1 SYEVSVPENAPPgTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024404317 2790 LQSTTVKVIINVLDENDN 2807
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2093-2186 1.43e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.58  E-value: 1.43e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2093 TYIPENTPIDTIVFKAQATDPDSGPNSYIEYSLLRP-LGNKFSIGTIDGEVRLIGELDREAVSNYTLTVVATDKGQPSLS 2171
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGnEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....*
gi 2024404317 2172 SSTDVVVIVLDINDN 2186
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2405-2500 6.20e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 121.65  E-value: 6.20e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2405 YSATVPEDAPTGTDILLVNSSDADASRNAVISYRLTGGNSQ--FTINPSTGQIITSALLDRETRENYTLIVVASDGGYPR 2482
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*...
gi 2024404317 2483 aLSSSTSVLVAVADVNDN 2500
Cdd:cd11304     82 -LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 242-345 1.75e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.50  E-value: 1.75e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  242 YQARVPEDAPVGASVLQVAAADADEGTNADIRYRLEGGDGGGgegasslPFEVDPESGVIRIRERLDYELCQQYSLTVQA 321
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDG-------LFSIDPSTGEITTAKPLDREEQSSYTLTVTA 74

                           90       100
                   ....*....|....*....|....
gi 2024404317  322 TDRGVPALSGRAEALIRLLDVNDN 345
Cdd:cd11304     75 TDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 729-825 1.97e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.50  E-value: 1.97e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  729 QYFAHIQENEPAGTYVTTVSATDPDMGPNGTVKYSISAGDTSR-FQVHGKTGIITTKIALDREEKTAYQLQIVATDGGHL 807
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024404317  808 QSQNQAIVTITVLDTQDN 825
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 613-721 2.93e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 119.73  E-value: 2.93e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  613 YQVSLAENSPSGTELLVLSAVDGDLGDNGTIRFSLqeaepavvavgpSSVTPRQVFRLDPVSGKLSTISQLDREEQAHFS 692
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI------------VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYT 69

                           90       100
                   ....*....|....*....|....*....
gi 2024404317  693 LQVLATDLGSPPLSSVARVNVSLLDVNDN 721
Cdd:cd11304     70 LTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1036-1132 6.20e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.96  E-value: 6.20e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1036 SYEITILESEPVNSRFFKVHATDKDSGVNGEIAYSIIEGNAGDAFGIFPD-GQLYIKSELDRELQERYILLVVASDRAVE 1114
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPStGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024404317 1115 PLNATVNITVILEDVNDN 1132
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1984-2082 2.05e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.41  E-value: 2.05e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1984 SYSTSLMENLAPGSAILNFSVTDADDGSNSQLSFSIASGDSMGHFGID-NSGVLSTQQPLDRESQSFYSLVVQVHDMAPL 2062
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDpSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90       100
                   ....*....|....*....|
gi 2024404317 2063 PASrytSTAQVSIILLDVND 2082
Cdd:cd11304     81 PLS---STATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 490-603 3.43e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 116.64  E-value: 3.43e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  490 VYRVNISEEVPLGSYVRGLTATDRDSGLNANLRYSIVSGNELGWFHISEHSGLVttagpgggtaghaggaSVTSGLDRET 569
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEI----------------TTAKPLDREE 64

                           90       100       110
                   ....*....|....*....|....*....|....
gi 2024404317  570 TSQVVLNISARDQGVQPKFSYAQLVVTILDINDN 603
Cdd:cd11304     65 QSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1881-1976 1.30e-29

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 115.10  E-value: 1.30e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1881 VYSFDIPEDATPGSLVAAILATDDDSGINGEITYTVSEDDEEGMFFLNPVTGVFNLTRALDYEAQQYYILTIRAEDGGG- 1959
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                           90
                   ....*....|....*...
gi 2024404317 1960 -QFATIRVYFNILDINDN 1976
Cdd:cd11304     81 pLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2730-2809 1.91e-29

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 113.98  E-value: 1.91e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  2730 AVDRDSGLNGQLIYEIIEGNTENSFSINRATGEIRSVRPLDREKLSRYTLTIKASDKGTPLQSTTVKVIINVLDENDNAP 2809
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
2195-2285 3.05e-28

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 110.85  E-value: 3.05e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2195 YRVELEENTLTGTDLIQVLATDGDEGTNGQVRYSIVSGDTGNQFRIDSVTGVITVAKPLDREKKPSYMLTVQSSDRGSSP 2274
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 2024404317 2275 RTDTTTVNIVL 2285
Cdd:pfam00028   81 LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2214-2293 4.72e-28

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 110.13  E-value: 4.72e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  2214 ATDGDEGTNGQVRYSIVSGDTGNQFRIDSVTGVITVAKPLDREKKPSYMLTVQSSDRGSSPRTDTTTVNIVLKDVNDYVP 2293
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1374-1454 4.82e-27

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 107.05  E-value: 4.82e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  1374 TATDSDSGDNADLHYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIYVRDFNDNP 1453
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024404317  1454 P 1454
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3150-3230 6.98e-27

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 106.66  E-value: 6.98e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  3150 SARDRDAAMNGLIRYNISSGNEAGNFAINTTTGTLTLAKPLDFELCQKHELIVTATDGGWVSRTGFCSVTINVIDVNDNS 3229
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024404317  3230 P 3230
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3237-3331 2.25e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 2.25e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3237 YFPNVLENAPSGTTVIRLNASDADSGPNAVIAYAIQSSDSD-LFVIDPNTGTITTQGFLDYETKQSYHLTIKAFNVPDEE 3315
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDgLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*.
gi 2024404317 3316 RCSFASVNIQLEGTNE 3331
Cdd:cd11304     82 LSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1269-1349 3.06e-26

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 104.74  E-value: 3.06e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  1269 SASDVDEGTNGLIHYSVIKGNEEKQFAIDSSTGQVTLVGKLDHEATASYSLVIQAVDSGAVSLSSTCTLSIDVLDENDNS 1348
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024404317  1349 P 1349
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2814-2906 3.11e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.47  E-value: 3.11e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2814 IFSASVPENAPLGFTVTRVTTSDEDIGMNAISRYSIR--DTSLPFVINPSTGDITVSRLLNREDTDRYRIRVSAHDSG-- 2889
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGgp 80

                           90
                   ....*....|....*...
gi 2024404317 2890 -WTVSTDVTVFVTDVNDN 2906
Cdd:cd11304     81 pLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1783-1873 3.74e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.47  E-value: 3.74e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1783 LTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDS-FHVDPESGDLIATKRLDRERRSKYSLLVRADDG---LQS 1858
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGlFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGggpPLS 83

                           90
                   ....*....|....*
gi 2024404317 1859 SDMRINITVSDVNDH 1873
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2712-2802 3.71e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 102.38  E-value: 3.71e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2712 FIAEIVENLSP-RKLLTVAAVDRDSGLNGQLIYEIIEGNTENSFSINRATGEIRSVRPLDREKLSRYTLTIKASDKGTPL 2790
Cdd:pfam00028    1 YSASVPENAPVgTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 2024404317 2791 QSTTVKVIINVL 2802
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3552-3648 3.89e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.39  E-value: 3.89e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3552 QGEVMENNRAGTLVMTLQSSDPDLPPNqGPFTYYLLStGPATSYFSL-STAGVLTTTREIDREQISDFYLSVITRDSGIP 3630
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGEN-GEVTYSIVS-GNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 2024404317 3631 QMSSTGTVQIKVIDQNDN 3648
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1357-1446 4.64e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 101.99  E-value: 4.64e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1357 SVDVLENMRVGELVSSVTATDSDSGDNADLHYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPR 1436
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|
gi 2024404317 1437 SSTMSVVIYV 1446
Cdd:pfam00028   82 SSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 935-1028 7.60e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 101.62  E-value: 7.60e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  935 SVNVVENWKAGHTIFQAKALDPDEGVNGMVLYSL-KQNPKGLFSINEQTGAISLIGQLDINA-GTYQVEILASDMGVPQL 1012
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEqSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 2024404317 1013 SSTFVLTVSVHDVNDN 1028
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
3133-3223 1.18e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 100.84  E-value: 1.18e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3133 SVTIPESHSVGAVIRTVSARDRDAAMNGLIRYNISSGNEAGNFAINTTTGTLTLAKPLDFELCQKHELIVTATDGGWVSR 3212
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|.
gi 2024404317 3213 TGFCSVTINVI 3223
Cdd:pfam00028   82 SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2109-2188 3.35e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 98.96  E-value: 3.35e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  2109 QATDPDSGPNSYIEYSLLR-PLGNKFSIGTIDGEVRLIGELDREAVSNYTLTVVATDKGQPSLSSSTDVVVIVLDINDNN 2187
Cdd:smart00112    1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024404317  2188 P 2188
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
2095-2181 3.54e-24

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 99.30  E-value: 3.54e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2095 IPENTPIDTIVFKAQATDPDSGPNSYIEYSLLR-PLGNKFSIGTIDGEVRLIGELDREAVSNYTLTVVATDKGQPSLSSS 2173
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGgGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                   ....*...
gi 2024404317 2174 TDVVVIVL 2181
Cdd:pfam00028   85 ATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1464-1561 5.36e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 99.31  E-value: 5.36e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1464 SIIENIPVGSSVISVTANDSDADINGQLTYAIIQQTPrGNHFRIDEVRGTIFTNAEIDREFANLFELTVKATDQAVPves 1543
Cdd:cd11304      5 SVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP--- 80

                           90
                   ....*....|....*...
gi 2024404317 1544 RRFALKNVTILVMDQNDN 1561
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 4015-4178 5.37e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 100.96  E-value: 5.37e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 4015 SYGFEELSYMEFPSMDP--NNNYIYIKFATIKRNALMLYNydnQTGERAEFLALEIIEGRLRFSYNLGSGTYKLTTTKKV 4092
Cdd:cd00110      1 GVSFSGSSYVRLPTLPAprTRLSISFSFRTTSPNGLLLYA---GSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 4093 SDGQFHTVIARRAGMAASLTVDSCSedqepgycTVSNVAVSTDWTLDVQPNrLTVGGirsVEPILQRRGQVESHDFVGCI 4172
Cdd:cd00110     78 NDGQWHSVSVERNGRSVTLSVDGER--------VVESGSPGGSALLNLDGP-LYLGG---LPEDLKSPGLPVSPGFVGCI 145


                   ....*.
gi 2024404317 4173 MEFAVN 4178
Cdd:cd00110    146 RDLKVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3341-3438 1.30e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.15  E-value: 1.30e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3341 YYFEVSEAASEGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQIDERSGQIYVSGPLDREKEERISLKVLAKNFGSir 3420
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG-- 79

                           90
                   ....*....|....*...
gi 2024404317 3421 GADIDEVTVNITILDAND 3438
Cdd:cd11304     80 PPLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2425-2502 1.52e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 97.42  E-value: 1.52e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  2425 SDADASRNAVISYRLTGGN--SQFTINPSTGQIITSALLDRETRENYTLIVVASDGGYPRaLSSSTSVLVAVADVNDNPP 2502
Cdd:smart00112    3 TDADSGENGKVTYSILSGNddGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP-LSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2914-3017 2.15e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.38  E-value: 2.15e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2914 SYYLECPELPGIGLKVTQVSATDPDEGSNGHVFYFIKSQSE--FFRINATTGEIFNKQYLRYQNssgssnvnINRHSFIV 2991
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREE--------QSSYTLTV 72

                           90       100
                   ....*....|....*....|....*.
gi 2024404317 2992 TSSDRGSPPLLSETTVTINIVDSNDN 3017
Cdd:cd11304     73 TATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2611-2703 2.28e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.38  E-value: 2.28e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2611 TFTFPENQAVGTLVTTISGSSA---RGGSLSYYIASGNLGNTFIVDQVTGQLSVGQALDFEAIQKYVVWIEARDTGFPPF 2687
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPdsgENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 2024404317 2688 SSYKKLEVTVVDVNDN 2703
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
242-340 2.86e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 96.99  E-value: 2.86e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  242 YQARVPEDAPVGASVLQVAAADADEGTNADIRYRLEGGDggggegaSSLPFEVDPESGVIRIRERLDYELCQQYSLTVQA 321
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGG-------PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEA 73

                           90
                   ....*....|....*....
gi 2024404317  322 TDRGVPALSGRAEALIRLL 340
Cdd:pfam00028   74 TDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3465-3546 3.64e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 96.26  E-value: 3.64e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  3465 SAFDSDSVPSWsRFSYFIGSGNDNSAFSINPQTGQVTVTAELDRETLPVYNLSVLAIDSGTPSATGSASLLVTLEDINDN 3544
Cdd:smart00112    1 SATDADSGENG-KVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 2024404317  3545 GP 3546
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 509-605 4.25e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.88  E-value: 4.25e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317   509 TATDRDSGLNANLRYSIVSGNELGWFHISEHSGLVttagpgggtaghaggaSVTSGLDRETTSQVVLNISARDQGVQPKF 588
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEI----------------TTTKPLDREEQPEYTLTVEATDGGGPPLS 64

                            90
                    ....*....|....*..
gi 2024404317   589 SYAQLVVTILDINDNKP 605
Cdd:smart00112   65 STATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
491-598 4.84e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 96.22  E-value: 4.84e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  491 YRVNISEEVPLGSYVRGLTATDRDSGLNANLRYSIVSGNELGWFHISEHSGLVttagpgggtaghaggaSVTSGLDRETT 570
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDI----------------STTKPLDRESI 64

                           90       100
                   ....*....|....*....|....*...
gi 2024404317  571 SQVVLNISARDQGVQPKFSYAQLVVTIL 598
Cdd:pfam00028   65 GEYELTVEATDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
613-716 5.71e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.83  E-value: 5.71e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  613 YQVSLAENSPSGTELLVLSAVDGDLGDNGTIRFSLqeaepavvavgpSSVTPRQVFRLDPVSGKLSTISQLDREEQAHFS 692
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI------------LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYE 68

                           90       100
                   ....*....|....*....|....
gi 2024404317  693 LQVLATDLGSPPLSSVARVNVSLL 716
Cdd:pfam00028   69 LTVEATDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
3447-3539 7.35e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.83  E-value: 7.35e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3447 YNVQISEGVPPGTHVTFVSAFDSDSVPSWsRFSYFIGSGNDNSAFSINPQTGQVTVTAELDRETLPVYNLSVLAIDSGTP 3526
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNG-RIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 2024404317 3527 SATGSASLLVTLE 3539
Cdd:pfam00028   80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1251-1342 9.10e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.45  E-value: 9.10e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1251 YQATISELAANLTQVLRVSASDVDEGTNGLIHYSVIKGNEEKQFAIDSSTGQVTLVGKLDHEATASYSLVIQAVDSGAVS 1330
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 2024404317 1331 LSSTCTLSIDVL 1342
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1141-1242 2.22e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.69  E-value: 2.22e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1141 YVFYFEEEQSGGSYVGKINAVDKDFGPNGEVRYSF--EHMQPDFELNTITGEIRSTHQFDREALmrqrgaAVFSLTVIAT 1218
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQ------SSYTLTVTAT 75

                           90       100
                   ....*....|....*....|....
gi 2024404317 1219 DQGLPkPLKDQATVQIYMKDINDN 1242
Cdd:cd11304     76 DGGGP-PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
730-820 2.41e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 94.29  E-value: 2.41e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  730 YFAHIQENEPAGTYVTTVSATDPDMGPNGTVKYSISAGDTSR-FQVHGKTGIITTKIALDREEKTAYQLQIVATDGGHLQ 808
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 2024404317  809 SQNQAIVTITVL 820
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 126-233 3.15e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 94.30  E-value: 3.15e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  126 SIVVTFKEDTGSGRQLILDTATDADSGTNGvdHSSYRIVSGNEEGRFRLNITlnpSGEgaflhLVSQGGLDREATPSYQL 205
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENG--EVTYSIVSGNEDGLFSIDPS---TGE-----ITTAKPLDREEQSSYTL 70

                           90       100
                   ....*....|....*....|....*...
gi 2024404317  206 LVQVEDKGEPRRRGYLQVNVTVQDINDN 233
Cdd:cd11304     71 TVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2299-2396 4.60e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.53  E-value: 4.60e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2299 PYNVNVPENLEtLPKVILQVVARDDDQGLNSKLTYVLVSGNEEGAFIL-SASGELRLVQSLDRERKEQYVLLITAADSGS 2377
Cdd:cd11304      1 SYEVSVPENAP-PGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIdPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 2024404317 2378 PALTGTGTITVTVDDVNDN 2396
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2405-2494 4.90e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 93.52  E-value: 4.90e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2405 YSATVPEDAPTGTDILLVNSSDADASRNAVISYRLTGGNS--QFTINPSTGQIITSALLDRETRENYTLIVVASDGGYPr 2482
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPggNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP- 79

                           90
                   ....*....|..
gi 2024404317 2483 ALSSSTSVLVAV 2494
Cdd:pfam00028   80 PLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 834-925 5.75e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.53  E-value: 5.75e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  834 YGFVVFENVALGYHVGTVFASTMDLNTN--ISYLITTGDQRGMFAINKVTGQITTASIIDREEQAFYQLKVVASGGAV-- 909
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENgeVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGpp 81

                           90
                   ....*....|....*..
gi 2024404317  910 -TGDTIVNITVKDLNDN 925
Cdd:cd11304     82 lSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 631-723 6.67e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.41  E-value: 6.67e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317   631 SAVDGDLGDNGTIRFSLqeaepavvavgpSSVTPRQVFRLDPVSGKLSTISQLDREEQAHFSLQVLATDLGSPPLSSVAR 710
Cdd:smart00112    1 SATDADSGENGKVTYSI------------LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTAT 68

                            90
                    ....*....|...
gi 2024404317   711 VNVSLLDVNDNSP 723
Cdd:smart00112   69 VTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 261-347 7.00e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.41  E-value: 7.00e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317   261 AADADEGTNADIRYRLEGGDGgggegasSLPFEVDPESGVIRIRERLDYELCQQYSLTVQATDRGVPALSGRAEALIRLL 340
Cdd:smart00112    2 ATDADSGENGKVTYSILSGND-------DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                    ....*..
gi 2024404317   341 DVNDNEP 347
Cdd:smart00112   75 DVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2003-2085 8.84e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.03  E-value: 8.84e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  2003 SVTDADDGSNSQLSFSIASGDSMGHFGID-NSGVLSTQQPLDRESQSFYSLVVQVHDMAPLPASrytSTAQVSIILLDVN 2081
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDpETGEITTTKPLDREEQPEYTLTVEATDGGGPPLS---STATVTITVLDVN 77


                    ....
gi 2024404317  2082 DSPP 2085
Cdd:smart00112   78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1055-1134 8.84e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.03  E-value: 8.84e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  1055 HATDKDSGVNGEIAYSIIEGNAGDAFGIFPD-GQLYIKSELDRELQERYILLVVASDRAVEPLNATVNITVILEDVNDNR 1133
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPEtGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024404317  1134 P 1134
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
1985-2078 1.21e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 92.36  E-value: 1.21e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1985 YSTSLMENLAPGSAILNFSVTDADDGSNSQLSFSIASGDSMGHFGID-NSGVLSTQQPLDRESQSFYSLVVQVHDMAPLP 2063
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDpDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|....*
gi 2024404317 2064 ASrytSTAQVSIILL 2078
Cdd:pfam00028   81 LS---STATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 748-827 1.34e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 91.64  E-value: 1.34e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317   748 SATDPDMGPNGTVKYSISAGDTSR-FQVHGKTGIITTKIALDREEKTAYQLQIVATDGGHLQSQNQAIVTITVLDTQDNP 826
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGlFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024404317   827 P 827
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
1037-1125 1.68e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 91.98  E-value: 1.68e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1037 YEITILESEPVNSRFFKVHATDKDSGVNGEIAYSIIEGNAGDAFGIFPD-GQLYIKSELDRELQERYILLVVASDRAVEP 1115
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 2024404317 1116 L--NATVNITVI 1125
Cdd:pfam00028   81 LssTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1901-1978 2.53e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.87  E-value: 2.53e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  1901 ATDDDSGINGEITYTVSEDDEEGMFFLNPVTGVFNLTRALDYEAQQYYILTIRAEDGGGQ--FATIRVYFNILDINDNPP 1978
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPplSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
1882-1971 3.02e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 91.21  E-value: 3.02e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1882 YSFDIPEDATPGSLVAAILATDDDSGINGEITYTVSEDDEEGMFFLNPVTGVFNLTRALDYEAQQYYILTIRAEDGG--G 1959
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgpP 80

                           90
                   ....*....|..
gi 2024404317 1960 QFATIRVYFNIL 1971
Cdd:pfam00028   81 LSSTATVTITVL 92
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 4288-4411 1.41e-20

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 90.56  E-value: 1.41e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 4288 FRTRSENGILFHI-QESSNFTTVKIRAGKVHYISDAGiAGKVERNIPEVYTADGQWHSVRIEKNGSTTVLSVDKTHKRDI 4366
Cdd:pfam02210    1 FRTRQPNGLLLYAgGGGSDFLALELVNGRLVLRYDLG-SGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 2024404317 4367 lHVTQDFGGLNVLT-ISLGGIPPNQPFKSTV--AGFDGCISYIKYGGE 4411
Cdd:pfam02210   80 -LPPGESLLLNLNGpLYLGGLPPLLLLPALPvrAGFVGCIRDVRVNGE 126
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1799-1875 1.84e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.56  E-value: 1.84e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  1799 TAMDADEGANALVTYTIISGADDS-FHVDPESGDLIATKRLDRERRSKYSLLVRADDG---LQSSDMRINITVSDVNDHI 1874
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGlFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVNDNA 80


                    .
gi 2024404317  1875 P 1875
Cdd:smart00112   81 P 81
LamG smart00282
Laminin G domain;
4283-4411 2.64e-20

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 89.71  E-value: 2.64e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  4283 SLEVKFRTRSENGILFHIQES--SNFTTVKIRAGKVHYISDAGIAGKVERNIPEVYtADGQWHSVRIEKNGSTTVLSVDK 4360
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKggGDYLALELRDGRLVLRYDLGSGPARLTSDPTPL-NDGQWHRVAVERNGRSVTLSVDG 79

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2024404317  4361 THKRDIlHVTQDFGGLNVLT-ISLGGIPPNQ--PFKSTVAGFDGCISYIKYGGE 4411
Cdd:smart00282   80 GNRVSG-ESPGGLTILNLDGpLYLGGLPEDLklPPLPVTPGFRGCIRNLKVNGK 132
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3026-3121 3.25e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.52  E-value: 3.25e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3026 YFTPVTKNVRAGTNLIKVTAVDdKDFGLNSEVEYFVSDESKTNKFRLDRSTGWISVSSSLMADLNKKFLFKVKAKDKGNP 3105
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATD-PDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*.
gi 2024404317 3106 PLSSEVAVEIVVTEEN 3121
Cdd:cd11304     81 PLSSTATVTITVLDVN 96
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 360-482 3.62e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 88.14  E-value: 3.62e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  360 FASVDENAAPGTVVALLTVSDADSPaANGNISVSILAGNEQRHFEVHsskvPNLSLIKVAAALDRERIPAYNLTVAVADn 439
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSG-ENGEVTYSIVSGNEDGLFSID----PSTGEITTAKPLDREEQSSYTLTVTATD- 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 2024404317  440 yGASPPppgfptsslspdgvaatpvsRSSVASLVIFVNDINDH 482
Cdd:cd11304     77 -GGGPP--------------------LSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
3241-3327 5.17e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.74  E-value: 5.17e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3241 VLENAPSGTTVIRLNASDADSGPNAVIAYAIQSSDSD-LFVIDPNTGTITTQGFLDYETKQSYHLTIKAFNVPDEERCSF 3319
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                   ....*...
gi 2024404317 3320 ASVNIQLE 3327
Cdd:pfam00028   85 ATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 145-235 6.79e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 87.02  E-value: 6.79e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317   145 TATDADSGTNGvdHSSYRIVSGNEEGRFRLNITlnpSGEgaflhLVSQGGLDREATPSYQLLVQVEDKGEPRRRGYLQVN 224
Cdd:smart00112    1 SATDADSGENG--KVTYSILSGNDDGLFSIDPE---TGE-----ITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVT 70

                            90
                    ....*....|.
gi 2024404317   225 VTVQDINDNPP 235
Cdd:smart00112   71 ITVLDVNDNAP 81
LamG smart00282
Laminin G domain;
4035-4180 7.82e-20

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 88.55  E-value: 7.82e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  4035 YIYIKFATIKRNALMLYNYDNQTGEraeFLALEIIEGRLRFSYNLGSGTYKLT-TTKKVSDGQFHTVIARRAGMAASLTV 4113
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGD---YLALELRDGRLVLRYDLGSGPARLTsDPTPLNDGQWHRVAVERNGRSVTLSV 77

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024404317  4114 DSCSEdqepgyctVSNVAVSTDWTLDVqPNRLTVGGirsVEPILQRRGQVESHDFVGCIMEFAVNGR 4180
Cdd:smart00282   78 DGGNR--------VSGESPGGLTILNL-DGPLYLGG---LPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 952-1030 8.92e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 86.63  E-value: 8.92e-20
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317   952 KALDPDEGVNGMVLYSLKQ-NPKGLFSINEQTGAISLIGQLD-INAGTYQVEILASDMGVPQLSSTFVLTVSVHDVNDNP 1029
Cdd:smart00112    1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDrEEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024404317  1030 P 1030
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
3551-3643 1.63e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 86.20  E-value: 1.63e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3551 RQGEVMENNRAGTLVMTLQSSDPDLPPNQGPFtyYLLSTGPATSYFSLSTA-GVLTTTREIDREQISDFYLSVITRDSGI 3629
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIF--YSILGGGPGGNFRIDPDtGDISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 2024404317 3630 PQMSSTGTVQIKVI 3643
Cdd:pfam00028   79 PPLSSTATVTITVL 92
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 4275-4404 1.75e-19

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 88.24  E-value: 1.75e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 4275 SPGPLNVDSLEVKFRTRSENGILFHI--QESSNFTTVKIRAGKVHYISDAGIAGKVERNIPEVytADGQWHSVRIEKNGS 4352
Cdd:cd00110     15 LPAPRTRLSISFSFRTTSPNGLLLYAgsQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPL--NDGQWHSVSVERNGR 92

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2024404317 4353 TTVLSVDKTHKRDILHVTQDFGGLNVLTISLGGIPPN--QPFKSTVAGFDGCIS 4404
Cdd:cd00110     93 SVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDlkSPGLPVSPGFVGCIR 146
Cadherin pfam00028
Cadherin domain;
1784-1867 6.87e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 84.27  E-value: 6.87e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1784 TVEENIGDGSKIMQLTAMDADEGANALVTYTIISG-ADDSFHVDPESGDLIATKRLDRERRSKYSLLVRADDGL---QSS 1859
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgppLSS 83


                   ....*...
gi 2024404317 1860 DMRINITV 1867
Cdd:pfam00028   84 TATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2933-3019 1.30e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 83.17  E-value: 1.30e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  2933 SATDPDEGSNGHVFYFIKSQSE--FFRINATTGEIFNKQYLRYQNssgssnvnINRHSFIVTSSDRGSPPLLSETTVTIN 3010
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDdgLFSIDPETGEITTTKPLDREE--------QPEYTLTVEATDGGGPPLSSTATVTIT 72


                    ....*....
gi 2024404317  3011 IVDSNDNAP 3019
Cdd:smart00112   73 VLDVNDNAP 81
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 4040-4180 2.04e-18

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 84.39  E-value: 2.04e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 4040 FATIKRNALMLYNydnqTGERAEFLALEIIEGRLRFSYNLGSGTYKLT-TTKKVSDGQFHTVIARRAGMAASLTVDSCSe 4118
Cdd:pfam02210    1 FRTRQPNGLLLYA----GGGGSDFLALELVNGRLVLRYDLGSGPESLLsSGKNLNDGQWHSVRVERNGNTLTLSVDGQT- 75

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024404317 4119 dqepgyctvSNVAVSTDWTLDVQPNR-LTVGGIRSVEPIlqrRGQVESHDFVGCIMEFAVNGR 4180
Cdd:pfam02210   76 ---------VVSSLPPGESLLLNLNGpLYLGGLPPLLLL---PALPVRAGFVGCIRDVRVNGE 126
Laminin_G_1 pfam00054
Laminin G domain;
4040-4183 4.23e-18

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 83.52  E-value: 4.23e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 4040 FATIKRNALMLYNydnQTGERAEFLALEIIEGRLRFSYNLGSGTYKLTTTKKVSDGQFHTVIARRAGMAASLTVDSCsed 4119
Cdd:pfam00054    1 FRTTEPSGLLLYN---GTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGE--- 74

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024404317 4120 QEPGYCTVSnvavSTDWTLDVqPNRLTVGGIrsvePIL--QRRGQVESHDFVGCIMEFAVNGRPLE 4183
Cdd:pfam00054   75 ARPTGESPL----GATTDLDV-DGPLYVGGL----PSLgvKKRRLAISPSFDGCIRDVIVNGKPLD 131
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2635-2705 5.64e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 81.24  E-value: 5.64e-18
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024404317  2635 GSLSYYIASGNLGNTFIVDQVTGQLSVGQALDFEAIQKYVVWIEARDTGFPPFSSYKKLEVTVVDVNDNAP 2705
Cdd:smart00112   11 GKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1159-1244 9.19e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.86  E-value: 9.19e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  1159 NAVDKDFGPNGEVRYSF--EHMQPDFELNTITGEIRSTHQFDREALmrqrgaAVFSLTVIATDQGLPkPLKDQATVQIYM 1236
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTKPLDREEQ------PEYTLTVEATDGGGP-PLSSTATVTITV 73


                    ....*...
gi 2024404317  1237 KDINDNAP 1244
Cdd:smart00112   74 LDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2833-2908 1.15e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.47  E-value: 1.15e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  2833 TTSDEDIGMNAISRYSI--RDTSLPFVINPSTGDITVSRLLNREDTDRYRIRVSAHDSG---WTVSTDVTVFVTDVNDNA 2907
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGgppLSSTATVTITVLDVNDNA 80


                    .
gi 2024404317  2908 P 2908
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
1464-1540 3.61e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.65  E-value: 3.61e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 2024404317 1464 SIIENIPVGSSVISVTANDSDADINGQLTYAIIQQtPRGNHFRIDEVRGTIFTNAEIDREFANLFELTVKATDQAVP 1540
Cdd:pfam00028    4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG-GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79
Cadherin pfam00028
Cadherin domain;
2611-2697 4.79e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 79.27  E-value: 4.79e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2611 TFTFPENQAVGTLVTTISGS---SARGGSLSYYIASGNLGNTFIVDQVTGQLSVGQALDFEAIQKYVVWIEARDTGFPPF 2687
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATdpdLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|
gi 2024404317 2688 SSYKKLEVTV 2697
Cdd:pfam00028   82 SSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1479-1563 5.05e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.55  E-value: 5.05e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  1479 TANDSDADINGQLTYAIIQQTPrGNHFRIDEVRGTIFTNAEIDREFANLFELTVKATDQAVPvesRRFALKNVTILVMDQ 1558
Cdd:smart00112    1 SATDADSGENGKVTYSILSGND-DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP---PLSSTATVTITVLDV 76


                    ....*
gi 2024404317  1559 NDNVP 1563
Cdd:smart00112   77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3571-3649 2.29e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.62  E-value: 2.29e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  3571 SDPDLPPNqGPFTYYLLStGPATSYFSL-STAGVLTTTREIDREQISDFYLSVITRDSGIPQMSSTGTVQIKVIDQNDNP 3649
Cdd:smart00112    3 TDADSGEN-GKVTYSILS-GNDDGLFSIdPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3900-3936 2.30e-16

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 75.37  E-value: 2.30e-16
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2024404317 3900 DIDECL-PSPCHNDGTCHNLVGGFSCSCPDGFTGMACE 3936
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3255-3334 2.89e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.62  E-value: 2.89e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  3255 NASDADSGPNAVIAYAI-QSSDSDLFVIDPNTGTITTQGFLDYETKQSYHLTIKAFNVPDEERCSFASVNIQLEGTNEYV 3333
Cdd:smart00112    1 SATDADSGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024404317  3334 P 3334
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3360-3440 3.58e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 76.23  E-value: 3.58e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  3360 ASDRDLGTDGEVHYLIFGNSRKKGFQIDERSGQIYVSGPLDREKEERISLKVLAKNFGSIRgaDIDEVTVNITILDANDP 3439
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPP--LSSTATVTITVLDVNDN 79


                    .
gi 2024404317  3440 P 3440
Cdd:smart00112   80 A 80
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 859-927 8.36e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 75.08  E-value: 8.36e-16
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024404317   859 NTNISYLITTGDQRGMFAINKVTGQITTASIIDREEQAFYQLKVVASGGAV---TGDTIVNITVKDLNDNSP 927
Cdd:smart00112   10 NGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGpplSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1579-1661 9.60e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.81  E-value: 9.60e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1579 IGSILTTIIAADPDEGANGEVEYEIINGDT-KTFIVDRYSGDLRVASAL-VPSQLIYNLIVSATDLGPERRKSTTEMTII 1656
Cdd:cd11304     12 PGTVVLTVSATDPDSGENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLdREEQSSYTLTVTATDGGGPPLSSTATVTIT 91


                   ....*
gi 2024404317 1657 LQGVD 1661
Cdd:cd11304     92 VLDVN 96
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2508-2595 9.88e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.43  E-value: 9.88e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2508 PYVTHVPSPTTSGSFVFAVTVTDADAGSNAELHYSLMGKNA-EKFHIDSARGAILAANELSGE--SEVTISVHVRDGGRY 2584
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdGLFSIDPSTGEITTAKPLDREeqSSYTLTVTATDGGGP 80

                           90
                   ....*....|.
gi 2024404317 2585 PKTDSTTVTVR 2595
Cdd:cd11304     81 PLSSTATVTIT 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1670-1772 2.13e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 74.66  E-value: 2.13e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1670 YITILKEGEPIGTNVISIEASSP-RGSEAQVEYYIVSvrcedKSLGRLFTIGRHTGVIQTAAILDREQgVRLYLVDVYAI 1748
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPdSGENGEVTYSIVS-----GNEDGLFSIDPSTGEITTAKPLDREE-QSSYTLTVTAT 75

                           90       100
                   ....*....|....*....|....
gi 2024404317 1749 EkSSVLPRTQRAEVEITLQDINDN 1772
Cdd:cd11304     76 D-GGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
2815-2901 2.47e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 2.47e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2815 FSASVPENAPLGFTVTRVTTSDEDIGMNAISRYSIR--DTSLPFVINPSTGDITVSRLLNREDTDRYRIRVSAHDSG--- 2889
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgpp 80

                           90
                   ....*....|..
gi 2024404317 2890 WTVSTDVTVFVT 2901
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
3341-3434 2.75e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.26  E-value: 2.75e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3341 YYFEVSEAASEGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQIDERSGQIYVSGPLDREKEERISLKVLAKNfGSIR 3420
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD-SGGP 79

                           90
                   ....*....|....
gi 2024404317 3421 GADiDEVTVNITIL 3434
Cdd:pfam00028   80 PLS-STATVTITVL 92
EGF_CA smart00179
Calcium-binding EGF-like domain;
3900-3936 3.90e-15

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 71.89  E-value: 3.90e-15
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2024404317  3900 DIDECL-PSPCHNDGTCHNLVGGFSCSCPDGFT-GMACE 3936
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2319-2398 3.97e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.15  E-value: 3.97e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  2319 VARDDDQGLNSKLTYVLVSGNEEGAF-ILSASGELRLVQSLDRERKEQYVLLITAADSGSPALTGTGTITVTVDDVNDNV 2397
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFsIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 2024404317  2398 P 2398
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
834-919 4.34e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.49  E-value: 4.34e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  834 YGFVVFENVALGYHVGTVFASTMDL--NTNISYLITTGDQRGMFAINKVTGQITTASIIDREEQAFYQLKVVAS---GGA 908
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLgpNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATdsgGPP 80

                           90
                   ....*....|.
gi 2024404317  909 VTGDTIVNITV 919
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
2300-2380 4.74e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.49  E-value: 4.74e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2300 YNVNVPENLETLPKViLQVVARDDDQGLNSKLTYVLVSGNEEGAFIL-SASGELRLVQSLDRERKEQYVLLITAADSGSP 2378
Cdd:pfam00028    1 YSASVPENAPVGTEV-LTVTATDPDLGPNGRIFYSILGGGPGGNFRIdPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79


                   ..
gi 2024404317 2379 AL 2380
Cdd:pfam00028   80 PL 81
Cadherin pfam00028
Cadherin domain;
2915-3011 4.74e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.49  E-value: 4.74e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2915 YYLECPELPGIGLKVTQVSATDPDEGSNGHVFYFIKSQSE--FFRINATTGEIFNKQYLRYQnssgssnvNINRHSFIVT 2992
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPggNFRIDPDTGDISTTKPLDRE--------SIGEYELTVE 72

                           90
                   ....*....|....*....
gi 2024404317 2993 SSDRGSPPLLSETTVTINI 3011
Cdd:pfam00028   73 ATDSGGPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
935-1023 6.47e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.10  E-value: 6.47e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  935 SVNVVENWKAGHTIFQAKALDPDEGVNGMVLYS-LKQNPKGLFSINEQTGAISLIGQLDINA-GTYQVEILASDMGVPQL 1012
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRESiGEYELTVEATDSGGPPL 81

                           90
                   ....*....|.
gi 2024404317 1013 SSTFVLTVSVH 1023
Cdd:pfam00028   82 SSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
361-446 9.19e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 72.72  E-value: 9.19e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  361 ASVDENAAPGTVVALLTVSDADSPaANGNISVSILAGNEQRHFEVHsskvPNLSLIKVAAALDRERIPAYNLTVAVADNy 440
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLG-PNGRIFYSILGGGPGGNFRID----PDTGDISTTKPLDRESIGEYELTVEATDS- 76


                   ....*.
gi 2024404317  441 gASPPP 446
Cdd:pfam00028   77 -GGPPL 81
Cadherin pfam00028
Cadherin domain;
1141-1234 7.18e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.02  E-value: 7.18e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1141 YVFYFEEEQSGGSYVGKINAVDKDFGPNGEVRYSF--EHMQPDFELNTITGEIRSTHQFDREALmrqrgaAVFSLTVIAT 1218
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSIlgGGPGGNFRIDPDTGDISTTKPLDRESI------GEYELTVEAT 74

                           90
                   ....*....|....*.
gi 2024404317 1219 DQGLPkPLKDQATVQI 1234
Cdd:pfam00028   75 DSGGP-PLSSTATVTI 89
Cadherin pfam00028
Cadherin domain;
127-228 1.41e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 1.41e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  127 IVVTFKEDTGSGRQLILDTATDADSGTNGVDhsSYRIVSGNEEGRFRLNITlnpSGEgaflhLVSQGGLDREATPSYQLL 206
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRI--FYSILGGGPGGNFRIDPD---TGD-----ISTTKPLDRESIGEYELT 70

                           90       100
                   ....*....|....*....|..
gi 2024404317  207 VQVEDKGEPRRRGYLQVNVTVQ 228
Cdd:pfam00028   71 VEATDSGGPPLSSTATVTITVL 92
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3938-3973 1.51e-13

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 67.28  E-value: 1.51e-13
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2024404317 3938 DVNECLS-NPCKNGAACQNFPGTFNCICKTGYTGKTC 3973
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 3048-3125 1.65e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.53  E-value: 1.65e-13
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 2024404317  3048 DKDFGLNSEVEYFVSDESKTNKFRLDRSTGWISVSSSLMADLNKKFLFKVKAKDKGNPPLSSEVAVEIVVTEENYHTP 3125
Cdd:smart00112    4 DADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 377-484 4.36e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.37  E-value: 4.36e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317   377 TVSDADSPAaNGNISVSILAGNEQRHFEVHsskvPNLSLIKVAAALDRERIPAYNLTVAVADnyGASPPppgfptsslsp 456
Cdd:smart00112    1 SATDADSGE-NGKVTYSILSGNDDGLFSID----PETGEITTTKPLDREEQPEYTLTVEATD--GGGPP----------- 62

                            90       100
                    ....*....|....*....|....*...
gi 2024404317   457 dgvaatpvsRSSVASLVIFVNDINDHPP 484
Cdd:smart00112   63 ---------LSSTATVTITVLDVNDNAP 81
EGF_CA smart00179
Calcium-binding EGF-like domain;
3938-3974 2.70e-12

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 63.81  E-value: 2.70e-12
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 2024404317  3938 DVNECLS-NPCKNGAACQNFPGTFNCICKTGYT-GKTCD 3974
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
Cadherin pfam00028
Cadherin domain;
1579-1658 1.01e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.86  E-value: 1.01e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1579 IGSILTTIIAADPDEGANGEVEYEIINGDTK-TFIVDRYSGDLRVASAL-VPSQLIYNLIVSATDLGPERRKSTTEMTII 1656
Cdd:pfam00028   11 VGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTTKPLdRESIGEYELTVEATDSGGPPLSSTATVTIT 90


                   ..
gi 2024404317 1657 LQ 1658
Cdd:pfam00028   91 VL 92
Cadherin pfam00028
Cadherin domain;
3026-3118 1.36e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.47  E-value: 1.36e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3026 YFTPVTKNVRAGTNLIKVTAVDdKDFGLNSEVEYFVSDESKTNKFRLDRSTGWISVSSSLMADLNKKFLFKVKAKDKGNP 3105
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATD-PDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 2024404317 3106 PLSSEVAVEIVVT 3118
Cdd:pfam00028   80 PLSSTATVTITVL 92
Laminin_G_1 pfam00054
Laminin G domain;
4288-4413 2.38e-11

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 64.26  E-value: 2.38e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 4288 FRTRSENGILFHI--QESSNFTTVKIRAGKVHYISDAGIAGKVERNIPEVytADGQWHSVRIEKNGSTTVLSVDKThkrD 4365
Cdd:pfam00054    1 FRTTEPSGLLLYNgtQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKL--NDGKWHSVELERNGRSGTLSVDGE---A 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024404317 4366 ILHVTQDFGGLNVL----TISLGGIPPN---QPFKSTVAGFDGCISYIKYGGESL 4413
Cdd:pfam00054   76 RPTGESPLGATTDLdvdgPLYVGGLPSLgvkKRRLAISPSFDGCIRDVIVNGKPL 130
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 3903-3936 6.11e-11

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 59.80  E-value: 6.11e-11
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2024404317 3903 EC-LPSPCHNDGTCHNLVGGFSCSCPDGFTGMA-CE 3936
Cdd:cd00053      1 ECaASNPCSNGGTCVNTPGSYRCVCPPGYTGDRsCE 36
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1588-1661 8.81e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.83  E-value: 8.81e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2024404317  1588 AADPDEGANGEVEYEIINGDTKT-FIVDRYSGDLRVASAL-VPSQLIYNLIVSATDLGPERRKSTTEMTIILQGVD 1661
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGlFSIDPETGEITTTKPLdREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1693-1774 2.34e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 59.67  E-value: 2.34e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317  1693 RGSEAQVEYYIVSvrcedKSLGRLFTIGRHTGVIQTAAILDREQGVRlYLVDVYAIEKSSVlPRTQRAEVEITLQDINDN 1772
Cdd:smart00112    7 SGENGKVTYSILS-----GNDDGLFSIDPETGEITTTKPLDREEQPE-YTLTVEATDGGGP-PLSSTATVTITVLDVNDN 79


                    ..
gi 2024404317  1773 PP 1774
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
2509-2594 3.29e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 59.62  E-value: 3.29e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2509 YVTHVPSPTTSGSFVFAVTVTDADAGSNAELHYSLMGKNAE-KFHIDSARGAILAANELSGE--SEVTISVHVRDGGRYP 2585
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGgNFRIDPDTGDISTTKPLDREsiGEYELTVEATDSGGPP 80


                   ....*....
gi 2024404317 2586 KTDSTTVTV 2594
Cdd:pfam00028   81 LSSTATVTI 89
EGF_CA pfam07645
Calcium-binding EGF domain;
3900-3929 1.17e-09

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 56.09  E-value: 1.17e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2024404317 3900 DIDECL--PSPCHNDGTCHNLVGGFSCSCPDG 3929
Cdd:pfam07645    1 DVDECAtgTHNCPANTVCVNTIGSFECRCPDG 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 3942-3972 1.31e-09

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 56.24  E-value: 1.31e-09
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2024404317 3942 CLSNPCKNGAACQNFPGTFNCICKTGYTGKT 3972
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 35-118 2.03e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 57.71  E-value: 2.03e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317   35 VFQVLEEQPAGTWVGTI-AT------RPGFTYRLSEHHA--LFSINATSGALHTRASIDRESLASdvVDLVVL-----SS 100
Cdd:cd11304      3 EVSVPENAPPGTVVLTVsATdpdsgeNGEVTYSIVSGNEdgLFSIDPSTGEITTAKPLDREEQSS--YTLTVTatdggGP 80

                           90
                   ....*....|....*...
gi 2024404317  101 QPTYPSEVRVLVLDLNDN 118
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 3904-3932 9.13e-09

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 53.54  E-value: 9.13e-09
                           10        20
                   ....*....|....*....|....*....
gi 2024404317 3904 CLPSPCHNDGTCHNLVGGFSCSCPDGFTG 3932
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF smart00181
Epidermal growth factor-like domain;
3903-3936 1.58e-08

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 53.29  E-value: 1.58e-08
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2024404317  3903 ECLP-SPCHNdGTCHNLVGGFSCSCPDGFTGMA-CE 3936
Cdd:smart00181    1 ECASgGPCSN-GTCINTPGSYTCSCPPGYTGDKrCE 35
Cadherin pfam00028
Cadherin domain;
1670-1767 1.79e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 54.61  E-value: 1.79e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1670 YITILKEGEPIGTNVISIEASSP-RGSEAQVEYYIVSvrcedKSLGRLFTIGRHTGVIQTAAILDREQgVRLYLVDVYAI 1748
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPdLGPNGRIFYSILG-----GGPGGNFRIDPDTGDISTTKPLDRES-IGEYELTVEAT 74

                           90
                   ....*....|....*....
gi 2024404317 1749 EKSSVlPRTQRAEVEITLQ 1767
Cdd:pfam00028   75 DSGGP-PLSSTATVTITVL 92
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4467-4500 2.76e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.64  E-value: 2.76e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2024404317 4467 CAS-SPCQNGGSCEPGPqASFTCSCPESYVGQRCE 4500
Cdd:cd00054      5 CASgNPCQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 3941-3973 7.12e-08

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 51.32  E-value: 7.12e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2024404317 3941 EC-LSNPCKNGAACQNFPGTFNCICKTGYTG-KTC 3973
Cdd:cd00053      1 ECaASNPCSNGGTCVNTPGSYRCVCPPGYTGdRSC 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 3977-4012 2.10e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 2.10e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2024404317 3977 VNYCE-CNPCFNGGSCQSGLEGYYCHCPFGVFGNHCE 4012
Cdd:cd00054      2 IDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 57-120 5.58e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 50.04  E-value: 5.58e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024404317    57 FTYRLS--EHHALFSINATSGALHTRASIDRESLasDVVDLVVL-----SSQPTYPSEVRVLVLDLNDNAP 120
Cdd:smart00112   13 VTYSILsgNDDGLFSIDPETGEITTTKPLDREEQ--PEYTLTVEatdggGPPLSSTATVTITVLDVNDNAP 81
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 4204-4236 1.55e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 1.55e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2024404317 4204 CTT-SPCQHGGTCTDHWSWQQCQCKDGLTGDHCE 4236
Cdd:cd00054      5 CASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
3977-4012 2.56e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 2.56e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 2024404317  3977 VNYCE-CNPCFNGGSCQSGLEGYYCHCPFG-VFGNHCE 4012
Cdd:smart00179    2 IDECAsGNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 3980-4010 2.67e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 46.61  E-value: 2.67e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2024404317 3980 CECNPCFNGGSCQSGLEGYYCHCPFGVFGNH 4010
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
4467-4500 2.91e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 2.91e-06
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2024404317  4467 CAS-SPCQNGGSCEPGPqASFTCSCPESYV-GQRCE 4500
Cdd:smart00179    5 CASgNPCQNGGTCVNTV-GSYRCECPPGYTdGRNCE 39
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 3906-3932 2.99e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 46.82  E-value: 2.99e-06
                           10        20
                   ....*....|....*....|....*..
gi 2024404317 3906 PSPCHNDGTCHNLVGGFSCSCPDGFTG 3932
Cdd:pfam12947    5 NGGCHPNATCTNTGGSFTCTCNDGYTG 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 4467-4500 3.73e-06

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 46.32  E-value: 3.73e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2024404317 4467 CA-SSPCQNGGSCEPGPqASFTCSCPESYVGQ-RCE 4500
Cdd:cd00053      2 CAaSNPCSNGGTCVNTP-GSYRCVCPPGYTGDrSCE 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 4467-4498 5.35e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 45.84  E-value: 5.35e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2024404317 4467 CASSPCQNGGSCEPGPQaSFTCSCPESYVGQR 4498
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPG-GYTCICPEGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 4204-4236 6.98e-06

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 45.55  E-value: 6.98e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2024404317 4204 CTTS-PCQHGGTCTDHWSWQQCQCKDGLTGD-HCE 4236
Cdd:cd00053      2 CAASnPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
EGF_CA pfam07645
Calcium-binding EGF domain;
3938-3967 9.55e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 45.31  E-value: 9.55e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2024404317 3938 DVNECLS--NPCKNGAACQNFPGTFNCICKTG 3967
Cdd:pfam07645    1 DVDECATgtHNCPANTVCVNTIGSFECRCPDG 32
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 3909-3930 9.70e-06

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 45.02  E-value: 9.70e-06
                           10        20
                   ....*....|....*....|..
gi 2024404317 3909 CHNDGTCHNLVGGFSCSCPDGF 3930
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF smart00181
Epidermal growth factor-like domain;
3941-3973 1.11e-05

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 45.20  E-value: 1.11e-05
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 2024404317  3941 ECLS-NPCKNGAaCQNFPGTFNCICKTGYTG-KTC 3973
Cdd:smart00181    1 ECASgGPCSNGT-CINTPGSYTCSCPPGYTGdKRC 34
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 3981-4012 1.61e-05

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 44.77  E-value: 1.61e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2024404317 3981 EC---NPCFNGGSCQSGLEGYYCHCPFGVFGN-HCE 4012
Cdd:cd00053      1 ECaasNPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1782-1873 2.10e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 46.18  E-value: 2.10e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 1782 DLTVEENIGDGSKIMQLTAmdaDEGANALVTYTIISGADDS----FHVDPESGDLIATKRLDRERRSKY---SLLVRADD 1854
Cdd:cd00031      3 DGSAVEGRSRGSFRVSIPT---DLIASSGEIIKISAAGKEAlpswLHWEPHSGILEGLEKLDREDKGVHyisVSAASLGA 79

                           90
                   ....*....|....*....
gi 2024404317 1855 GLQSSDMRINITVSDVNDH 1873
Cdd:cd00031     80 NVPQTSSVFSIEVYDENDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 3455-3544 2.38e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 46.18  E-value: 2.38e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 3455 VPPGTHV------TFVSAFDSDSVPSWSRFSYFIGSGNDN--SAFSINPQTGQVTVTAELDRETLPVYNLSVLAIDSGTP 3526
Cdd:cd00031      1 IPDGSAVegrsrgSFRVSIPTDLIASSGEIIKISAAGKEAlpSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGAN 80

                           90
                   ....*....|....*...
gi 2024404317 3527 SATGSASLLVTLEDINDN 3544
Cdd:cd00031     81 VPQTSSVFSIEVYDENDN 98
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 3942-3973 2.77e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 43.74  E-value: 2.77e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2024404317 3942 CLSNP--CKNGAACQNFPGTFNCICKTGYT--GKTC 3973
Cdd:pfam12947    1 CSDNNggCHPNATCTNTGGSFTCTCNDGYTgdGVTC 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 4204-4234 3.48e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.53  E-value: 3.48e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2024404317 4204 CTTSPCQHGGTCTDHWSWQQCQCKDGLTGDH 4234
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 2470-2639 2.12e-04

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 48.11  E-value: 2.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2470 TLIVVASDGgyprALSSSTSVLVAVADVNdnppkfqHHPYVTHVPSPTT-SGSFV-FAVTVTDADAGSNAELHYSLMGKN 2547
Cdd:NF038112  1349 TFTLTVSDG----TASATDTVTVTVRNVN-------RAPVANAGADQTVdERSTVtLSGSATDPDGDALTYAWTQTAGPT 1417

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2548 AEKFHIDSARgAILAANELSGESEVTISVHVRDGGRYPKTDSTTVTVRFVNRAefPQVQAeQETFTFPENQAVgTLVTti 2627
Cdd:NF038112  1418 VTLTGADTAT-ASFTAPEVAADTELTFQLTVSADGQASADVTVTVTVRNVNRA--PVAHA-GESITVDEGSTV-TLDA-- 1490

                          170
                   ....*....|..
gi 2024404317 2628 SGSSARGGSLSY 2639
Cdd:NF038112  1491 SATDPDGDTLTY 1502
EGF_CA smart00179
Calcium-binding EGF-like domain;
4204-4236 2.53e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 2.53e-04
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 2024404317  4204 CTT-SPCQHGGTCTDHWSWQQCQCKDGLT-GDHCE 4236
Cdd:smart00179    5 CASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
Cadherin pfam00028
Cadherin domain;
34-113 1.07e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 41.13  E-value: 1.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317   34 QVFQVLEEQPAGTWVGTIATRP-------GFTYRLSEHHA--LFSINATSGALHTRASIDRESLASDVVDLVVLSSQP-- 102
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDpdlgpngRIFYSILGGGPggNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGpp 80

                           90
                   ....*....|..
gi 2024404317  103 -TYPSEVRVLVL 113
Cdd:pfam00028   81 lSSTATVTITVL 92
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 3947-3968 1.76e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 38.47  E-value: 1.76e-03
                           10        20
                   ....*....|....*....|..
gi 2024404317 3947 CKNGAACQNFPGTFNCICKTGY 3968
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2611-2703 2.46e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 40.41  E-value: 2.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024404317 2611 TFTFPENQAVGTLVTTIS----GSSARGGSLSyyiASGN--LGNTFIVDQVTGQLSVGQALDFEAIQKYVVWIEARDTGF 2684
Cdd:cd00031      3 DGSAVEGRSRGSFRVSIPtdliASSGEIIKIS---AAGKeaLPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGA 79

                           90
                   ....*....|....*....
gi 2024404317 2685 PPFSSYKKLEVTVVDVNDN 2703
Cdd:cd00031     80 NVPQTSSVFSIEVYDENDN 98
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 3985-4003 2.66e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 38.08  E-value: 2.66e-03
                           10
                   ....*....|....*....
gi 2024404317 3985 CFNGGSCQSGLEGYYCHCP 4003
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCP 19
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 664-721 3.82e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 40.02  E-value: 3.82e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2024404317  664 PRQVFRLDPVSGKLSTISQLDREEQAHFSLQVLATDLGSPPLSSVARVNVSLLDVNDN 721
Cdd:cd00031     41 LPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDENDN 98
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 4209-4229 4.01e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 37.70  E-value: 4.01e-03
                           10        20
                   ....*....|....*....|.
gi 2024404317 4209 CQHGGTCTDHWSWQQCQCKDG 4229
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPG 21
EGF smart00181
Epidermal growth factor-like domain;
4467-4500 4.89e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.50  E-value: 4.89e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2024404317  4467 CAS-SPCQNGgSCEPGPQaSFTCSCPESYVGQ-RCE 4500
Cdd:smart00181    2 CASgGPCSNG-TCINTPG-SYTCSCPPGYTGDkRCE 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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