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Conserved domains on  [gi|971385975|ref|XP_015133571|]
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lysocardiolipin acyltransferase 1 isoform X3 [Gallus gallus]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 10870651)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

EC:  2.3.1.-
Gene Ontology:  GO:0016746|GO:0008654|GO:0016020
PubMed:  18287005|18931347|18718904

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 55-248 9.25e-90

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


:

Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 268.34  E-value: 9.25e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975  55 VALLEMVFGAKVVVTGDGFI-PGERSVIIMNHRTRMDWMFLWNCLLRYSYLRLEKICLKSSLKSIPGFGWAMQVAAFIFI 133
Cdd:cd07990    1 VFLFEWLSGVKVVVYGDEPKlPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975 134 QRKWEDDKSHFENMLHYFCDIHEPLQLLIFPEGTDLTANTKARSNDFAEKNGLRKYEYVLHPRTTGFTFVVECLREGNnl 213
Cdd:cd07990   81 KRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDAV-- 158

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 971385975 214 DAIHDITVAYPQNIPQTEKHLLNGNFPKEIHFHVQ 248
Cdd:cd07990  159 DAVYDVTIAYPDGKPPSEQRLLLGGKPREVHVHVR 193
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 233-307 8.43e-21

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


:

Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 85.32  E-value: 8.43e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 971385975  233 HLLNGnFPKEIHFHVQRYPIETVPTSKEELQLWCQKRWEEKEERLRRFYEGGkCFDETGQSIIPPCKSELRVLAV 307
Cdd:pfam16076   1 SLLNG-KPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYETG-TFFPGKEHIIPRRLKSLLVFIF 73
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 55-248 9.25e-90

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 268.34  E-value: 9.25e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975  55 VALLEMVFGAKVVVTGDGFI-PGERSVIIMNHRTRMDWMFLWNCLLRYSYLRLEKICLKSSLKSIPGFGWAMQVAAFIFI 133
Cdd:cd07990    1 VFLFEWLSGVKVVVYGDEPKlPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975 134 QRKWEDDKSHFENMLHYFCDIHEPLQLLIFPEGTDLTANTKARSNDFAEKNGLRKYEYVLHPRTTGFTFVVECLREGNnl 213
Cdd:cd07990   81 KRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDAV-- 158

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 971385975 214 DAIHDITVAYPQNIPQTEKHLLNGNFPKEIHFHVQ 248
Cdd:cd07990  159 DAVYDVTIAYPDGKPPSEQRLLLGGKPREVHVHVR 193
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 5-318 1.36e-63

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 207.63  E-value: 1.36e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975   5 KGIYFVVALFLGSFFGSIFmLGP---FLPLMFiSPAWYRWITDRIVATWLTLPVALLEMVFGAKVVVTGDGFIPGERSVI 81
Cdd:PLN02510  19 RGLICLLVLLSTAFMMLVY-LAPvsaVLLRLF-SVHYSRKATSFFFGSWLALWPFLFEKINKTKVVFSGDKVPPEERVLL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975  82 IMNHRTRMDWMFLWNCLLRYSYLRLEKICLKSSLKSIPGFGWAMQVAAFIFIQRKWEDDKSHFENMLHYFCDIHEPLQLL 161
Cdd:PLN02510  97 IANHRTEVDWMYLWDLALRKGCLGYIKYVLKSSLMKLPVFGWAFHIFEFIPVERKWEVDEPNIRQMLSSFKDPRDPLWLA 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975 162 IFPEGTDLTANTKARSNDFAEKNGLRKYEYVLHPRTTGFTFVVECLRegNNLDAIHDITVAYPQNIPQtekhLLNGNF-- 239
Cdd:PLN02510 177 LFPEGTDYTEAKCQRSQKFAAEHGLPILNNVLLPKTKGFVSCLQELR--CSLDAVYDVTIGYKHRCPS----FLDNVFgi 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975 240 -PKEIHFHVQRYPIETVPTSKEELQLWCQKRWEEKEERLRRFYEGGKCFDETGQSIIPPCKSELRVLAVKCIS--LLYWT 316
Cdd:PLN02510 251 dPSEVHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFYAQGHFPNEGTEGELSTLKCLANFLAVIALTtvFTYLT 330


                 ..
gi 971385975 317 VF 318
Cdd:PLN02510 331 LF 332
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 233-307 8.43e-21

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 85.32  E-value: 8.43e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 971385975  233 HLLNGnFPKEIHFHVQRYPIETVPTSKEELQLWCQKRWEEKEERLRRFYEGGkCFDETGQSIIPPCKSELRVLAV 307
Cdd:pfam16076   1 SLLNG-KPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYETG-TFFPGKEHIIPRRLKSLLVFIF 73
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 80-170 9.18e-18

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 78.55  E-value: 9.18e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975    80 VIIMNHRTRMDWMFLWNCLLRYsyLRLEKICLKSSLKSIPGFGWAMQVAAFIFIQRKWEDDKSHfeNMLHYFCDIHEPLQ 159
Cdd:smart00563   2 LVVANHQSFLDPLVLSALLPRK--LGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARA--ALREAVELLKEGEW 77

                           90
                   ....*....|.
gi 971385975   160 LLIFPEGTDLT 170
Cdd:smart00563  78 LLIFPEGTRSR 88
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 65-223 1.13e-15

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 73.08  E-value: 1.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975   65 KVVVTGDGFIP-GERSVIIMNHRTRMDWMFLWNCLlrYSYLRLEKICLKSSLKSIPGFGWAMQVAAFIFIQRKWEDDKSH 143
Cdd:pfam01553   1 RIEVHGLENLPrGGPAIVVANHQSYLDVLLLSLAL--YKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975  144 FENMLHYFcdIHEPLQLLIFPEGTdltantkarsndfaeknglRKYEYVLHPRTTGFTFVVECLRegnnldaIHDITVAY 223
Cdd:pfam01553  79 TLEYLVEL--LREGKLVVIFPEGT-------------------RSREGELLPFKKGAFRLAIEAG-------VPIVPVAI 130
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 31-167 8.55e-14

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 69.65  E-value: 8.55e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975  31 LMFISPAWYRWITDRIVATWLTLpvallemvFGAKVVVTGDGFIPGERSVIIM-NHRTRMDWMFLWNCL-LRYSYLrlek 108
Cdd:COG0204    4 LFLLLRRFRYRLVRLWARLLLRL--------LGVRVRVEGLENLPADGPVLIVaNHQSWLDILLLLAALpRPVRFV---- 71

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975 109 icLKSSLKSIPGFGWAMQVAAFIFIQRKwedDKSHFENMLHYFCD-IHEPLQLLIFPEGT 167
Cdd:COG0204   72 --AKKELFKIPLLGWLLRALGAIPVDRS---KRRAALRALRQAVEaLKAGESLVIFPEGT 126
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 63-167 1.74e-06

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 46.96  E-value: 1.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975   63 GAKVVVTGDGFIPGERSVIIM-NHRTRMDWMFLwncllRYSYLRLEKICLKSSLKSIPGFGWAMQVAAFIFIQRkwEDDK 141
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVaNHQSNLDPLTL-----SAAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDR--ENIR 73

                          90       100       110
                  ....*....|....*....|....*....|...
gi 971385975  142 SHfENMLhyfcdiHEPLQLL-------IFPEGT 167
Cdd:TIGR00530  74 AI-ATAL------KAAIEVLkqgrsigVFPEGT 99
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 55-248 9.25e-90

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 268.34  E-value: 9.25e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975  55 VALLEMVFGAKVVVTGDGFI-PGERSVIIMNHRTRMDWMFLWNCLLRYSYLRLEKICLKSSLKSIPGFGWAMQVAAFIFI 133
Cdd:cd07990    1 VFLFEWLSGVKVVVYGDEPKlPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975 134 QRKWEDDKSHFENMLHYFCDIHEPLQLLIFPEGTDLTANTKARSNDFAEKNGLRKYEYVLHPRTTGFTFVVECLREGNnl 213
Cdd:cd07990   81 KRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDAV-- 158

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 971385975 214 DAIHDITVAYPQNIPQTEKHLLNGNFPKEIHFHVQ 248
Cdd:cd07990  159 DAVYDVTIAYPDGKPPSEQRLLLGGKPREVHVHVR 193
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 5-318 1.36e-63

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 207.63  E-value: 1.36e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975   5 KGIYFVVALFLGSFFGSIFmLGP---FLPLMFiSPAWYRWITDRIVATWLTLPVALLEMVFGAKVVVTGDGFIPGERSVI 81
Cdd:PLN02510  19 RGLICLLVLLSTAFMMLVY-LAPvsaVLLRLF-SVHYSRKATSFFFGSWLALWPFLFEKINKTKVVFSGDKVPPEERVLL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975  82 IMNHRTRMDWMFLWNCLLRYSYLRLEKICLKSSLKSIPGFGWAMQVAAFIFIQRKWEDDKSHFENMLHYFCDIHEPLQLL 161
Cdd:PLN02510  97 IANHRTEVDWMYLWDLALRKGCLGYIKYVLKSSLMKLPVFGWAFHIFEFIPVERKWEVDEPNIRQMLSSFKDPRDPLWLA 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975 162 IFPEGTDLTANTKARSNDFAEKNGLRKYEYVLHPRTTGFTFVVECLRegNNLDAIHDITVAYPQNIPQtekhLLNGNF-- 239
Cdd:PLN02510 177 LFPEGTDYTEAKCQRSQKFAAEHGLPILNNVLLPKTKGFVSCLQELR--CSLDAVYDVTIGYKHRCPS----FLDNVFgi 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975 240 -PKEIHFHVQRYPIETVPTSKEELQLWCQKRWEEKEERLRRFYEGGKCFDETGQSIIPPCKSELRVLAVKCIS--LLYWT 316
Cdd:PLN02510 251 dPSEVHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFYAQGHFPNEGTEGELSTLKCLANFLAVIALTtvFTYLT 330


                 ..
gi 971385975 317 VF 318
Cdd:PLN02510 331 LF 332
PLN02380 PLN02380
1-acyl-sn-glycerol-3-phosphate acyltransferase
 14-313 1.73e-35

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178006 [Multi-domain]  Cd Length: 376  Bit Score: 133.33  E-value: 1.73e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975  14 FLGSFFGSIFMLGPFLPLMFISPAWYRWItDRIVAT--WLTLpVALLEMVFGAKVVVTGDG----FIPGERSVIIMNHRT 87
Cdd:PLN02380  17 LLSGLIVNLIQAVCFILVRPLSKSLYRRI-NRAVAEllWLEL-IWLVDWWAGVKVQLYADEetfeLMGKEHALVISNHRS 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975  88 RMDWMFLWNCLLRYSYLRLEKICLKSSLKSIPGFGWAMQVAAFIFIQRKWEDDKSHFENMLHYFCDIHEPLQLLIFPEGT 167
Cdd:PLN02380  95 DIDWLVGWILAQRSGCLGSALAVMKKSSKFLPVIGWSMWFSEYVFLERSWAKDENTLKSGFQRLKDFPRPFWLALFVEGT 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975 168 DLTANTKARSNDFAEKNGLRKYEYVLHPRTTGFTFVVECLREgnNLDAIHDITVAYPQNIPQ-TEKHLLNGNfPKEIHFH 246
Cdd:PLN02380 175 RFTQAKLLAAQEYAASRGLPVPRNVLIPRTKGFVSAVSNMRS--FVPAIYDVTVAVPKGQPApTMLRIFRGQ-SSVVHVH 251

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 971385975 247 VQRYPIETVPTSKEELQLWCQKRWEEKEERLRRFYEGGKCFDETGQSIIPPCKSELRVLAVKCISLL 313
Cdd:PLN02380 252 IKRHSMKELPETDDGIAQWCKDVFVAKDALLDKHFAEDTFGDQEYQDIGRPKKSLIVVISWACLLIL 318
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 233-307 8.43e-21

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 85.32  E-value: 8.43e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 971385975  233 HLLNGnFPKEIHFHVQRYPIETVPTSKEELQLWCQKRWEEKEERLRRFYEGGkCFDETGQSIIPPCKSELRVLAV 307
Cdd:pfam16076   1 SLLNG-KPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYETG-TFFPGKEHIIPRRLKSLLVFIF 73
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 80-170 9.18e-18

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 78.55  E-value: 9.18e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975    80 VIIMNHRTRMDWMFLWNCLLRYsyLRLEKICLKSSLKSIPGFGWAMQVAAFIFIQRKWEDDKSHfeNMLHYFCDIHEPLQ 159
Cdd:smart00563   2 LVVANHQSFLDPLVLSALLPRK--LGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGRKARA--ALREAVELLKEGEW 77

                           90
                   ....*....|.
gi 971385975   160 LLIFPEGTDLT 170
Cdd:smart00563  78 LLIFPEGTRSR 88
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 65-223 1.13e-15

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 73.08  E-value: 1.13e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975   65 KVVVTGDGFIP-GERSVIIMNHRTRMDWMFLWNCLlrYSYLRLEKICLKSSLKSIPGFGWAMQVAAFIFIQRKWEDDKSH 143
Cdd:pfam01553   1 RIEVHGLENLPrGGPAIVVANHQSYLDVLLLSLAL--YKRGRPLVFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975  144 FENMLHYFcdIHEPLQLLIFPEGTdltantkarsndfaeknglRKYEYVLHPRTTGFTFVVECLRegnnldaIHDITVAY 223
Cdd:pfam01553  79 TLEYLVEL--LREGKLVVIFPEGT-------------------RSREGELLPFKKGAFRLAIEAG-------VPIVPVAI 130
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
 65-248 2.75e-15

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 73.60  E-value: 2.75e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975  65 KVVVTGDGFIPGERSVIIM-NHRTRMDWMFLWnCLLRYSYLRLEKICLK-SSLKSIPGFGWamqvAAFIFIQRKW-EDDK 141
Cdd:cd06551   13 RLEVKGPPPPPGGGPVLFVsNHSSWWDGLILF-LLLERGLRRDVYGLMDeELLERYPFFTR----LGAFSVDRDSpRSAA 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975 142 SHFENMLHYFCDIHEplQLLIFPEGTDLTantkarsndfAEKNGLRKYEYVLHP-RTTGFTFVVECLREGNNL-DAIHDI 219
Cdd:cd06551   88 KSLKYVARLLSKPGS--VVWIFPEGTRTR----------RDKRPLQFKPGVAHLaEKAGVPIVPVALRYTFELfEQFPEI 155

                        170       180       190
                 ....*....|....*....|....*....|..
gi 971385975 220 TVAYPQNIPQTEKH---LLNGNFPKEIHFHVQ 248
Cdd:cd06551  156 FVRIGPPIPYAETAlgeELAAELANRLTRLLD 187
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 31-167 8.55e-14

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 69.65  E-value: 8.55e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975  31 LMFISPAWYRWITDRIVATWLTLpvallemvFGAKVVVTGDGFIPGERSVIIM-NHRTRMDWMFLWNCL-LRYSYLrlek 108
Cdd:COG0204    4 LFLLLRRFRYRLVRLWARLLLRL--------LGVRVRVEGLENLPADGPVLIVaNHQSWLDILLLLAALpRPVRFV---- 71

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975 109 icLKSSLKSIPGFGWAMQVAAFIFIQRKwedDKSHFENMLHYFCD-IHEPLQLLIFPEGT 167
Cdd:COG0204   72 --AKKELFKIPLLGWLLRALGAIPVDRS---KRRAALRALRQAVEaLKAGESLVIFPEGT 126
PRK14014 PRK14014
putative acyltransferase; Provisional
 7-277 4.11e-11

putative acyltransferase; Provisional


Pssm-ID: 237584 [Multi-domain]  Cd Length: 301  Bit Score: 63.33  E-value: 4.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975   7 IYFVVALFLGSFfgsIFMLGPFLPLMFISPAWYR--WITDRIVATWLTLPVALLEMVFGAKVVVTGD-GFIPGERSVIIM 83
Cdd:PRK14014  17 LLILNTLFWSVP---IIILGLLKLLLPIPAIRRAcsRLLNFIAEAWISINNVILRLLPRTQWDVEGLeGLSKKGWYLVIS 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975  84 NHRTRMDWMFLwnCLLRYSYLRLEKICLKSSLKSIP--GFG-WAMQvaaFIFIQR------------KWEDDKS------ 142
Cdd:PRK14014  94 NHQSWVDILVL--QYVFNRRIPMLKFFLKQELIWVPflGLAwWALD---FPFMKRyskaylaknpelKGKDLETtrrace 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975 143 HFENMlhyfcdihePLQLLIFPEGTDLTANTKARSNDfaeknglrKYEYVLHPRTTGFTFVVECLreGNNLDAIHDITVA 222
Cdd:PRK14014 169 KFKRM---------PTTIVNFVEGTRFTPEKHQQQQS--------PYQHLLKPKAGGIAFALNAM--GEQFDGLLDVTIV 229

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 971385975 223 YPQNIPqTEKHLLNGNfPKEIHFHVQRYPIETV--------PTSKEELQLWCQKRWEEKEERL 277
Cdd:PRK14014 230 YPDGRP-SFWDLLSGR-VKKIVVHVRLLPIPEEligdyfndKEFRRRFQQWLNQLWQEKDQLI 290
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 61-167 7.97e-11

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 60.36  E-value: 7.97e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975  61 VFGAKVVVTGDGFIPGERSVIIM-NHRTRMDWMFLWNCLLRY-SYLrlekicLKSSLKSIPGFGWAMQVAAFIFIQR-KW 137
Cdd:cd07989    7 LLGVRVRVEGLENLPPKGPVIIVaNHQSYLDPLVLGAALPRPiRFV------AKKELFKIPFLGWLLRLLGAIPIDRgNG 80

                         90       100       110
                 ....*....|....*....|....*....|
gi 971385975 138 EDDKSHFENMLHYfcdIHEPLQLLIFPEGT 167
Cdd:cd07989   81 RSAREALREAIEA---LKEGESVVIFPEGT 107
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 63-167 1.74e-06

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 46.96  E-value: 1.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975   63 GAKVVVTGDGFIPGERSVIIM-NHRTRMDWMFLwncllRYSYLRLEKICLKSSLKSIPGFGWAMQVAAFIFIQRkwEDDK 141
Cdd:TIGR00530   1 GLKVEVVGPENLPAKSPVLVVaNHQSNLDPLTL-----SAAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFIDR--ENIR 73

                          90       100       110
                  ....*....|....*....|....*....|...
gi 971385975  142 SHfENMLhyfcdiHEPLQLL-------IFPEGT 167
Cdd:TIGR00530  74 AI-ATAL------KAAIEVLkqgrsigVFPEGT 99
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 80-167 1.42e-04

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 42.59  E-value: 1.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971385975  80 VIIMNHRTRMDWMFLWNCLLrYSYLRlekiclKSSLKSIPGFGWAMQVAAFIFIQRKWEDDKSHFENMLHYFCDIHEPLQ 159
Cdd:cd07991   27 IIVANHTSFIDPLILFSDLF-PSIVA------KKELGKLPFIGTILRALGCIFVDRSEPKDRKKVVEEIKERATDPNWPP 99


                 ....*...
gi 971385975 160 LLIFPEGT 167
Cdd:cd07991  100 ILIFPEGT 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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