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Conserved domains on  [gi|971404011|ref|XP_015144615|]
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fibronectin isoform X2 [Gallus gallus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 418-466 2.63e-23

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


:

Pssm-ID: 128373  Cd Length: 49  Bit Score: 94.67  E-value: 2.63e-23
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 971404011    418 GNSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTENYDADQKFGFC 466
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 358-406 5.73e-23

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


:

Pssm-ID: 128373  Cd Length: 49  Bit Score: 93.52  E-value: 5.73e-23
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 971404011    358 GNSDGEACVLPFTYNGRTFYSCTTEGRTDGHLWCSTTSNFEQDRRYSFC 406
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
fn3 pfam00041
Fibronectin type III domain;
1544-1625 7.75e-20

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 85.93  E-value: 7.75e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  1544 DVPRDLEVNPTSPTSLEISWDAPAV---TVRYYRITYGETGGSSPVQEFTVPGTMSRATITGLKPGVDYTITVYAVTGRG 1620
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 971404011  1621 DSPAS 1625
Cdd:pfam00041   81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
1454-1534 2.68e-18

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 81.69  E-value: 2.68e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  1454 DSPTGLDFSDITANSFTVHWIAPR---ATITGYKIRHHPEHGVGRPKEDRVPPSRNSITLTNLLPGTEYVVSIIAVNGRE 1530
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 971404011  1531 ESVP 1534
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
1363-1444 5.38e-17

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 77.84  E-value: 5.38e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  1363 PPPTDLRFTNVGPDTMRVTWTAPT--SIVLSSFLVRYSPVKKEEDVAELTISPSDNVVVLTNLLPGTEYLVRVYSVAEQH 1440
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 971404011  1441 ESAP 1444
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
1638-1718 9.37e-17

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 77.07  E-value: 9.37e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  1638 DTPSQMQVTDVQDNSISIRWLPS---SSPVTGYRVTAVPKKGHGPTKTKNVPPDQTQVTIEGLQPTVEYMVSVYAQNQNG 1714
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 971404011  1715 ESLP 1718
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1065-1633 2.95e-16

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 85.05  E-value: 2.95e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1065 EYTVYLVAVKEDLQSARETGVFTTYQPVGSVPPFNTEVTETSIVITWTPAPRIGFKLGVRPSQGGEAPREVISDSGSIVI 1144
Cdd:COG3401    21 TAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGS 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1145 SGLTPGVEYTYSLTVLMDGQERETPIIRRVTTPLSPPTN--LRLEPNPDTGILIVSWDRSTTPGISGYRVTTAPTNGQQG 1222
Cdd:COG3401   101 GSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGtyALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAV 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1223 STLEEVVGADQTSCTFENLNPGVEYNVSVYAVKDDQESIP---ISKTITQEVPQL-TDLSFVDITDSSIGLRWTPLNAST 1298
Cdd:COG3401   181 ATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPsneVSVTTPTTPPSApTGLTATADTPGSVTLSWDPVTESD 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1299 IIGYRI--TVVAAGESVPIfedfVDSSVGYYTVTGLEPGIDYDISVITLINGG-ESAP----TTLTQQTAVPPPTDLRFT 1371
Cdd:COG3401   261 ATGYRVyrSNSGDGPFTKV----ATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPsnvvSVTTDLTPPAAPSGLTAT 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1372 NVGPDTMRVTWTAPTSIVLSSFLVrYSPVKKEEDVAELTISPSDNVVVLTNLLPGTEYLVRVYSV-AEQHESAP------ 1444
Cdd:COG3401   337 AVGSSSITLSWTASSDADVTGYNV-YRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdAAGNESAPseevsa 415

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1445 --LSGIQKTGLDSPTGLDFSDITANSFTVHWIAPRATITGYKIRHhpeHGVGRPKEDRVPPSRNSITLTNLLPGTEYVVS 1522
Cdd:COG3401   416 ttASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLAD---GGDTGNAVPFTTTSSTVTATTTDTTTANLSVT 492

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1523 IIAVNGREESVPLVGQQTTVSDVPRDLEVNPTSPTSLEISWDAPAVTVRYYRITYGETGGSSPVQEFTVPGTMSRATITG 1602
Cdd:COG3401   493 TGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSGAGLGSGNLY 572

                         570       580       590
                  ....*....|....*....|....*....|.
gi 971404011 1603 LKPGVDYTITVYAVTGRGDSPASSKPVTVTY 1633
Cdd:COG3401   573 LITTLGGSLLTTTSTNTNDVAGVHGGTLLVL 603
fn3 pfam00041
Fibronectin type III domain;
1818-1898 4.32e-16

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 75.14  E-value: 4.32e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  1818 PPPTNLKFTQVTPTSLTVNWNAP---NVRLTGYRVRVNPKEKTGPMKEINLSPDSTSAVVSGLMVATKYEVSVYALKDSL 1894
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 971404011  1895 TSRP 1898
Cdd:pfam00041   81 EGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 188-232 1.96e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 72.00  E-value: 1.96e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 971404011    188 CYDNTAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNR 232
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
2258-2297 2.34e-15

Fibronectin type I domain;


:

Pssm-ID: 459644  Cd Length: 40  Bit Score: 71.58  E-value: 2.34e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 971404011  2258 CYDTYTGSFYSIGEEWERLSETGFKLWCQCLGFGSGHFRC 2297
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2303-2345 4.28e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 71.23  E-value: 4.28e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 971404011   2303 CHDN--GVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFKCEPHET 2345
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2000-2080 5.48e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 72.53  E-value: 5.48e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 2000 DAPSNLRFLTTTTNSLLASWQPPR---AKITGYIIRYDKPGSPAKELLPRPRPGTTEATITGLEPGTEYTIYIIAVKNNQ 2076
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 971404011 2077 KSEP 2080
Cdd:cd00063    82 ESPP 85
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 566-608 6.32e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 70.46  E-value: 6.32e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 971404011    566 CQDSETRTFYQIGDSWEK-YVHGVRYQCYCYGRGIGEWHCQPLQ 608
Cdd:smart00058    1 CFDEETGTTYRVGDTWERpYEGGHVLQCTCLGGGRGEWKCDPVP 44
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 475-513 1.73e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.30  E-value: 1.73e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 971404011    475 CTTND-GIMYRVGDQWDKQHDMGHMMRCTCVGNGRGEWTC 513
Cdd:smart00058    1 CFDEEtGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKC 40
fn1 pfam00039
Fibronectin type I domain;
233-272 3.11e-14

Fibronectin type I domain;


:

Pssm-ID: 459644  Cd Length: 40  Bit Score: 68.49  E-value: 3.11e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 971404011   233 CNDQDTKTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKC 272
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
fn3 pfam00041
Fibronectin type III domain;
1002-1081 3.40e-14

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.75  E-value: 3.40e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  1002 DAPTNLRFINTTEHSVLVLWTRPR---AIISGYRLTAGPTRGGQP-RTYNVGPSATKYLLRNLQPGTEYTVYLVAVKEDL 1077
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 971404011  1078 QSAR 1081
Cdd:pfam00041   81 EGPP 84
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
728-1118 2.19e-13

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 75.81  E-value: 2.19e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  728 TSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGEQNLIL 807
Cdd:COG3401    53 GTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVA 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  808 STSQTTAPdAPPEHSVESVDDTSIVISWSRPQAPITGYRIVYTPSVEG-SSTELNLPDTATSVTLSDLMPGVQYNISIYA 886
Cdd:COG3401   133 GGAATAGT-YALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAvATTSLTVTSTTLVDGGGDIEPGTTYYYRVAA 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  887 VEEHQESTPVfiqQETTGVPRTDEVPSPKDLQFVEVSDVKVTIMWTPPQSQ-VSGYRVEaipvNRPGQHGQRLPITRSSF 965
Cdd:COG3401   212 TDTGGESAPS---NEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVY----RSNSGDGPFTKVATVTT 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  966 AEVVD--LLPGTTYLFKIFAV-SHGRESKP---LTGE-QTTKLDAPTNLRFINTTEHSVLVLWT-RPRAIISGYRLTAGP 1037
Cdd:COG3401   285 TSYTDtgLTNGTTYYYRVTAVdAAGNESAPsnvVSVTtDLTPPAAPSGLTATAVGSSSITLSWTaSSDADVTGYNVYRST 364

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1038 TRGGQPRTYNVGPSATKYLLRNLQPGTEYTVYLVAVKED-LQSARETGVFTTYQPVGSVPPFNTEVTETSIVITWTPAPR 1116
Cdd:COG3401   365 SGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAgNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAA 444


                  ..
gi 971404011 1117 IG 1118
Cdd:COG3401   445 AS 446
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 527-565 2.51e-13

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 66.22  E-value: 2.51e-13
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 971404011    527 GITYDVNQTFHKRHDEGHMLNCTCFGQGRGRWKCDPVDQ 565
Cdd:smart00058    7 GTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
99-137 8.33e-13

Fibronectin type I domain;


:

Pssm-ID: 459644  Cd Length: 40  Bit Score: 64.26  E-value: 8.33e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 971404011    99 CFDKYTGSTYRVGETYERPKDS-MIWDCTCIGAGRGRISC 137
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRgHVLQCTCLGNGGGEIRC 40
fn3 pfam00041
Fibronectin type III domain;
1910-1990 8.49e-13

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 8.49e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  1910 SPPRRARVTDATETTITITWRTKTE---TITGFQIDAIPAASGQNPIQRTISPDVRTYTITGLQPGNDYKIYLYTLNENA 1986
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 971404011  1987 RSSP 1990
Cdd:pfam00041   81 EGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 143-186 8.77e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


:

Pssm-ID: 214494  Cd Length: 45  Bit Score: 61.60  E-value: 8.77e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 971404011    143 CHEG--GKSYKIGDTWRRPHEtGGYLLECVCLGNGKGEWTCKPLAE 186
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYE-GGHVLQCTCLGGGRGEWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
616-693 2.36e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 2.36e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011   616 PVQVIITESTnqPNSHPIQWNAPKT--SHISKYILRWRPKISGRHWKEATIPGHLNSYTISGLKPGVVYEGQLISVQQHG 693
Cdd:pfam00041    3 PSNLTVTDVT--STSLTVSWTPPPDgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1728-1815 1.39e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.82  E-value: 1.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1728 DRPKGLTFTEVDVDSIKIAWESPQ---GQVTRYRVTYSSPEDGIHELLPAPGGEEDTAELHGLRPGSEYTINIVAIYDDM 1804
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 971404011 1805 ESLPLTGTQST 1815
Cdd:cd00063    82 ESPPSESVTVT 92
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 53-91 4.11e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


:

Pssm-ID: 238018  Cd Length: 43  Bit Score: 56.96  E-value: 4.11e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 971404011   53 TCFDN--GRYYQINQQWERIYLGNTLVCTCYGGSRGFNCES 91
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDP 42
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2346-2385 6.63e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


:

Pssm-ID: 238018  Cd Length: 43  Bit Score: 56.19  E-value: 6.63e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 971404011 2346 TCYDD--GKMYQVGEQWQKEYFGAICSCTCYGGQQGWRCDNC 2385
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDPV 43
fn3 pfam00041
Fibronectin type III domain;
2172-2230 6.28e-06

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 46.25  E-value: 6.28e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 971404011  2172 TISWRPLLES----TEYIISCQPVSQDEDTLQFRVPGTSSSATLTGLTRGATYNIIVEALKDH 2230
Cdd:pfam00041   17 TVSWTPPPDGngpiTGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 312-349 2.12e-04

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


:

Pssm-ID: 238018  Cd Length: 43  Bit Score: 40.78  E-value: 2.12e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 971404011  312 HCVTD-NGVVYSLGMQWLKTQGSQQMLCTCLGN--GVSCQE 349
Cdd:cd00061     2 KCFDPqTGVFYRVGETWERPSEGHVLQCTCLGNrgEARCDP 42
 
Name Accession Description Interval E-value
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 418-466 2.63e-23

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 94.67  E-value: 2.63e-23
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 971404011    418 GNSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTENYDADQKFGFC 466
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 358-406 5.73e-23

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 93.52  E-value: 5.73e-23
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 971404011    358 GNSDGEACVLPFTYNGRTFYSCTTEGRTDGHLWCSTTSNFEQDRRYSFC 406
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 419-466 2.26e-22

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 91.98  E-value: 2.26e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 971404011  419 NSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTENYDADQKFGFC 466
Cdd:cd00062     1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 359-406 3.89e-21

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 88.52  E-value: 3.89e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 971404011  359 NSDGEACVLPFTYNGRTFYSCTTEGRTDGHLWCSTTSNFEQDRRYSFC 406
Cdd:cd00062     1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
fn3 pfam00041
Fibronectin type III domain;
1544-1625 7.75e-20

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 85.93  E-value: 7.75e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  1544 DVPRDLEVNPTSPTSLEISWDAPAV---TVRYYRITYGETGGSSPVQEFTVPGTMSRATITGLKPGVDYTITVYAVTGRG 1620
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 971404011  1621 DSPAS 1625
Cdd:pfam00041   81 EGPPS 85
fn2 pfam00040
Fibronectin type II domain;
425-466 1.40e-19

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 83.77  E-value: 1.40e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 971404011   425 CHFPFLYNNRNYTDCTSEGRRDNMKWCGTTENYDADQKFGFC 466
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn2 pfam00040
Fibronectin type II domain;
365-406 2.13e-19

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 83.39  E-value: 2.13e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 971404011   365 CVLPFTYNGRTFYSCTTEGRTDGHLWCSTTSNFEQDRRYSFC 406
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn3 pfam00041
Fibronectin type III domain;
1454-1534 2.68e-18

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 81.69  E-value: 2.68e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  1454 DSPTGLDFSDITANSFTVHWIAPR---ATITGYKIRHHPEHGVGRPKEDRVPPSRNSITLTNLLPGTEYVVSIIAVNGRE 1530
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 971404011  1531 ESVP 1534
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
1363-1444 5.38e-17

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 77.84  E-value: 5.38e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  1363 PPPTDLRFTNVGPDTMRVTWTAPT--SIVLSSFLVRYSPVKKEEDVAELTISPSDNVVVLTNLLPGTEYLVRVYSVAEQH 1440
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 971404011  1441 ESAP 1444
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
1638-1718 9.37e-17

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 77.07  E-value: 9.37e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  1638 DTPSQMQVTDVQDNSISIRWLPS---SSPVTGYRVTAVPKKGHGPTKTKNVPPDQTQVTIEGLQPTVEYMVSVYAQNQNG 1714
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 971404011  1715 ESLP 1718
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1065-1633 2.95e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 85.05  E-value: 2.95e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1065 EYTVYLVAVKEDLQSARETGVFTTYQPVGSVPPFNTEVTETSIVITWTPAPRIGFKLGVRPSQGGEAPREVISDSGSIVI 1144
Cdd:COG3401    21 TAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGS 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1145 SGLTPGVEYTYSLTVLMDGQERETPIIRRVTTPLSPPTN--LRLEPNPDTGILIVSWDRSTTPGISGYRVTTAPTNGQQG 1222
Cdd:COG3401   101 GSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGtyALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAV 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1223 STLEEVVGADQTSCTFENLNPGVEYNVSVYAVKDDQESIP---ISKTITQEVPQL-TDLSFVDITDSSIGLRWTPLNAST 1298
Cdd:COG3401   181 ATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPsneVSVTTPTTPPSApTGLTATADTPGSVTLSWDPVTESD 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1299 IIGYRI--TVVAAGESVPIfedfVDSSVGYYTVTGLEPGIDYDISVITLINGG-ESAP----TTLTQQTAVPPPTDLRFT 1371
Cdd:COG3401   261 ATGYRVyrSNSGDGPFTKV----ATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPsnvvSVTTDLTPPAAPSGLTAT 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1372 NVGPDTMRVTWTAPTSIVLSSFLVrYSPVKKEEDVAELTISPSDNVVVLTNLLPGTEYLVRVYSV-AEQHESAP------ 1444
Cdd:COG3401   337 AVGSSSITLSWTASSDADVTGYNV-YRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdAAGNESAPseevsa 415

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1445 --LSGIQKTGLDSPTGLDFSDITANSFTVHWIAPRATITGYKIRHhpeHGVGRPKEDRVPPSRNSITLTNLLPGTEYVVS 1522
Cdd:COG3401   416 ttASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLAD---GGDTGNAVPFTTTSSTVTATTTDTTTANLSVT 492

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1523 IIAVNGREESVPLVGQQTTVSDVPRDLEVNPTSPTSLEISWDAPAVTVRYYRITYGETGGSSPVQEFTVPGTMSRATITG 1602
Cdd:COG3401   493 TGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSGAGLGSGNLY 572

                         570       580       590
                  ....*....|....*....|....*....|.
gi 971404011 1603 LKPGVDYTITVYAVTGRGDSPASSKPVTVTY 1633
Cdd:COG3401   573 LITTLGGSLLTTTSTNTNDVAGVHGGTLLVL 603
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1544-1632 3.01e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 76.00  E-value: 3.01e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1544 DVPRDLEVNPTSPTSLEISWDAPAVT---VRYYRITYGETGGSSPVQEFTVPGTMSRATITGLKPGVDYTITVYAVTGRG 1620
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 971404011 1621 DSPASSKPVTVT 1632
Cdd:cd00063    82 ESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
1818-1898 4.32e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 75.14  E-value: 4.32e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  1818 PPPTNLKFTQVTPTSLTVNWNAP---NVRLTGYRVRVNPKEKTGPMKEINLSPDSTSAVVSGLMVATKYEVSVYALKDSL 1894
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 971404011  1895 TSRP 1898
Cdd:pfam00041   81 EGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 188-232 1.96e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 72.00  E-value: 1.96e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 971404011    188 CYDNTAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNR 232
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
2258-2297 2.34e-15

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 71.58  E-value: 2.34e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 971404011  2258 CYDTYTGSFYSIGEEWERLSETGFKLWCQCLGFGSGHFRC 2297
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2258-2302 3.52e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 71.23  E-value: 3.52e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 971404011   2258 CYDTYTGSFYSIGEEWERLSETGFKLWCQCLGFGSGHFRCDSSKW 2302
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2303-2345 4.28e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 71.23  E-value: 4.28e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 971404011   2303 CHDN--GVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFKCEPHET 2345
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2000-2080 5.48e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 72.53  E-value: 5.48e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 2000 DAPSNLRFLTTTTNSLLASWQPPR---AKITGYIIRYDKPGSPAKELLPRPRPGTTEATITGLEPGTEYTIYIIAVKNNQ 2076
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 971404011 2077 KSEP 2080
Cdd:cd00063    82 ESPP 85
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 566-608 6.32e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 70.46  E-value: 6.32e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 971404011    566 CQDSETRTFYQIGDSWEK-YVHGVRYQCYCYGRGIGEWHCQPLQ 608
Cdd:smart00058    1 CFDEETGTTYRVGDTWERpYEGGHVLQCTCLGGGRGEWKCDPVP 44
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1498-1938 6.77e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 80.82  E-value: 6.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1498 EDRVPPSRNSITLTNLLPGTEYVVSIIAVNGREESVPLVGQQTTVSDVPRDLEVNPTSPTSLEISWDAPAVTVRYYRITY 1577
Cdd:COG3401    94 LTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPD 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1578 GETGGSSPVQEFTVPGTMSRATITGLKPGVDYTITVYAVTGRGDSPASsKPVTVTYKTEI-DTPSQMQVTDVQDNSISIR 1656
Cdd:COG3401   174 TSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPS-NEVSVTTPTTPpSAPTGLTATADTPGSVTLS 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1657 WLPSSSP-VTGYRVTAVPKKGHGPTKTKNVppDQTQVTIEGLQPTVEYMVSVYAQNQNGESLPLVETAVTNIDR-----P 1730
Cdd:COG3401   253 WDPVTESdATGYRVYRSNSGDGPFTKVATV--TTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVSVTTDLtppaaP 330

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1731 KGLTFTEVDVDSIKIAWE-SPQGQVTRYRVTYSSPEDGIHELLpAPGGEEDTAELHGLRPGSEYTINIVAIYDD-MESLP 1808
Cdd:COG3401   331 SGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGTYTKI-AETVTTTSYTDTGLTPGTTYYYKVTAVDAAgNESAP 409

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1809 LTGTQSTAIPPPTNLKFTQVTPTSLTVNWNAPNVRLTGYRVRVNPKEKTGPMKEI-NLSPDSTSAVVSGLMVATKYEVSV 1887
Cdd:COG3401   410 SEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTgNAVPFTTTSSTVTATTTDTTTANL 489

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 971404011 1888 YALKDSLTSRPAQGVVTTLENVSPPRRARVTDATETTITITWRTKTETITG 1938
Cdd:COG3401   490 SVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGA 540
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 475-513 1.73e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.30  E-value: 1.73e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 971404011    475 CTTND-GIMYRVGDQWDKQHDMGHMMRCTCVGNGRGEWTC 513
Cdd:smart00058    1 CFDEEtGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKC 40
fn3 pfam00041
Fibronectin type III domain;
2000-2080 2.72e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.14  E-value: 2.72e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  2000 DAPSNLRFLTTTTNSLLASWQPPR---AKITGYIIRY---DKPGSPAKELLPRPrpgTTEATITGLEPGTEYTIYIIAVK 2073
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYrpkNSGEPWNEITVPGT---TTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*..
gi 971404011  2074 NNQKSEP 2080
Cdd:pfam00041   78 GGGEGPP 84
fn1 pfam00039
Fibronectin type I domain;
233-272 3.11e-14

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 68.49  E-value: 3.11e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 971404011   233 CNDQDTKTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKC 272
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
fn1 pfam00039
Fibronectin type I domain;
188-227 3.39e-14

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 68.49  E-value: 3.39e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 971404011   188 CYDNTAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITC 227
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
fn3 pfam00041
Fibronectin type III domain;
1002-1081 3.40e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.75  E-value: 3.40e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  1002 DAPTNLRFINTTEHSVLVLWTRPR---AIISGYRLTAGPTRGGQP-RTYNVGPSATKYLLRNLQPGTEYTVYLVAVKEDL 1077
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 971404011  1078 QSAR 1081
Cdd:pfam00041   81 EGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 233-277 5.97e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 67.76  E-value: 5.97e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 971404011    233 CNDQDTKTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTS 277
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1363-1442 1.31e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 68.02  E-value: 1.31e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011   1363 PPPTDLRFTNVGPDTMRVTWTAPTSIVLSSFLVRYSPVKKEED--VAELTISPSDNVVVLTNLLPGTEYLVRVYSVAEQH 1440
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGseWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 971404011   1441 ES 1442
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1638-1725 1.55e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.29  E-value: 1.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1638 DTPSQMQVTDVQDNSISIRWLPSS---SPVTGYRVTAVPKKGHGPTKTKNVPPDQTQVTIEGLQPTVEYMVSVYAQNQNG 1714
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 971404011 1715 ESLPLVETAVT 1725
Cdd:cd00063    82 ESPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1454-1534 2.18e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.91  E-value: 2.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1454 DSPTGLDFSDITANSFTVHWIAPRAT---ITGYKIRHHPEHGVGRPKEDRVPPSRNSITLTNLLPGTEYVVSIIAVNGRE 1530
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 971404011 1531 ESVP 1534
Cdd:cd00063    82 ESPP 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
728-1118 2.19e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 75.81  E-value: 2.19e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  728 TSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGEQNLIL 807
Cdd:COG3401    53 GTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVA 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  808 STSQTTAPdAPPEHSVESVDDTSIVISWSRPQAPITGYRIVYTPSVEG-SSTELNLPDTATSVTLSDLMPGVQYNISIYA 886
Cdd:COG3401   133 GGAATAGT-YALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAvATTSLTVTSTTLVDGGGDIEPGTTYYYRVAA 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  887 VEEHQESTPVfiqQETTGVPRTDEVPSPKDLQFVEVSDVKVTIMWTPPQSQ-VSGYRVEaipvNRPGQHGQRLPITRSSF 965
Cdd:COG3401   212 TDTGGESAPS---NEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVY----RSNSGDGPFTKVATVTT 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  966 AEVVD--LLPGTTYLFKIFAV-SHGRESKP---LTGE-QTTKLDAPTNLRFINTTEHSVLVLWT-RPRAIISGYRLTAGP 1037
Cdd:COG3401   285 TSYTDtgLTNGTTYYYRVTAVdAAGNESAPsnvVSVTtDLTPPAAPSGLTATAVGSSSITLSWTaSSDADVTGYNVYRST 364

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1038 TRGGQPRTYNVGPSATKYLLRNLQPGTEYTVYLVAVKED-LQSARETGVFTTYQPVGSVPPFNTEVTETSIVITWTPAPR 1116
Cdd:COG3401   365 SGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAgNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAA 444


                  ..
gi 971404011 1117 IG 1118
Cdd:COG3401   445 AS 446
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 527-565 2.51e-13

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 66.22  E-value: 2.51e-13
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 971404011    527 GITYDVNQTFHKRHDEGHMLNCTCFGQGRGRWKCDPVDQ 565
Cdd:smart00058    7 GTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
816-887 2.91e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.05  E-value: 2.91e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 971404011   816 DAPPEHSVESVDDTSIVISWSRP---QAPITGYRIVYTPSVEGS-STELNLPDTATSVTLSDLMPGVQYNISIYAV 887
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
fn1 pfam00039
Fibronectin type I domain;
566-604 2.96e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 65.80  E-value: 2.96e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 971404011   566 CQDSETRTFYQIGDSWEK-YVHGVRYQCYCYGRGIGEWHC 604
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERpSQRGHVLQCTCLGNGGGEIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 815-903 3.79e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.14  E-value: 3.79e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  815 PDAPPEHSVESVDDTSIVISWSRPQ---APITGYRIVYTPSVEGSSTELNLPD-TATSVTLSDLMPGVQYNISIYAVEEH 890
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 971404011  891 QESTPVFIQQETT 903
Cdd:cd00063    81 GESPPSESVTVTT 93
fn1 pfam00039
Fibronectin type I domain;
475-513 3.89e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 65.41  E-value: 3.89e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 971404011   475 CTTND-GIMYRVGDQWDKQHDMGHMMRCTCVGNGRGEWTC 513
Cdd:pfam00039    1 CYDPQtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
fn1 pfam00039
Fibronectin type I domain;
99-137 8.33e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 64.26  E-value: 8.33e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 971404011    99 CFDKYTGSTYRVGETYERPKDS-MIWDCTCIGAGRGRISC 137
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRgHVLQCTCLGNGGGEIRC 40
fn3 pfam00041
Fibronectin type III domain;
1910-1990 8.49e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 8.49e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  1910 SPPRRARVTDATETTITITWRTKTE---TITGFQIDAIPAASGQNPIQRTISPDVRTYTITGLQPGNDYKIYLYTLNENA 1986
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 971404011  1987 RSSP 1990
Cdd:pfam00041   81 EGPP 84
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2256-2300 8.97e-13

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 64.28  E-value: 8.97e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 971404011 2256 DTCYDTYTGSFYSIGEEWERLSEtGFKLWCQCLGfGSGHFRCDSS 2300
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDPV 43
fn3 pfam00041
Fibronectin type III domain;
1272-1354 9.45e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 9.45e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  1272 PQLTDLSFVDITDSSIGLRWTPLNA--STIIGYRITVVAAGESVPIFEDFVDSSVGYYTVTGLEPGIDYDISVITLINGG 1349
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 971404011  1350 ESAPT 1354
Cdd:pfam00041   81 EGPPS 85
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 564-607 1.12e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 64.28  E-value: 1.12e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 971404011  564 DQCQDSETRTFYQIGDSWEKYVHGVRYQCYCYGrGIGEWHCQPL 607
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCDPV 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1363-1449 1.65e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 65.21  E-value: 1.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1363 PPPTDLRFTNVGPDTMRVTWTAPTSI--VLSSFLVRYSPVKKEEDVAELTISPSDNVVVLTNLLPGTEYLVRVYSVAEQH 1440
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....*....
gi 971404011 1441 ESAPLSGIQ 1449
Cdd:cd00063    82 ESPPSESVT 90
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1818-1905 1.70e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 65.21  E-value: 1.70e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1818 PPPTNLKFTQVTPTSLTVNWNAP---NVRLTGYRVRVNPKEKTGPMKEINLSPDSTSAVVSGLMVATKYEVSVYALKDSL 1894
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 971404011 1895 TSRPAQGVVTT 1905
Cdd:cd00063    82 ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1546-1622 2.85e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.56  E-value: 2.85e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011   1546 PRDLEVNPTSPTSLEISWDAPAVT-----VRYYRITYGETGGSspVQEFTVPGTMSRATITGLKPGVDYTITVYAVTGRG 1620
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSE--WKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 971404011   1621 DS 1622
Cdd:smart00060   82 EG 83
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 99-142 3.64e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 62.75  E-value: 3.64e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 971404011     99 CFDKYTGSTYRVGETYERPKDS-MIWDCTCIGAGRGRISCTIANR 142
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGgHVLQCTCLGGGRGEWKCDPVPV 45
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 815-893 4.55e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.79  E-value: 4.55e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011    815 PDAPPEHSVESVDDTSIVISWSRPQ-----APITGYRIVYTPSvEGSSTELNLPDTATSVTLSDLMPGVQYNISIYAVEE 889
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREE-GSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 971404011    890 HQES 893
Cdd:smart00060   80 AGEG 83
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 143-186 8.77e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 61.60  E-value: 8.77e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 971404011    143 CHEG--GKSYKIGDTWRRPHEtGGYLLECVCLGNGKGEWTCKPLAE 186
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYE-GGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1002-1088 1.07e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.90  E-value: 1.07e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1002 DAPTNLRFINTTEHSVLVLWTRPR---AIISGYRLTAGPTRGGQPRTYNVGP-SATKYLLRNLQPGTEYTVYLVAVKEDL 1077
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 971404011 1078 QSAR-ETGVFTT 1088
Cdd:cd00063    82 ESPPsESVTVTT 93
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 186-229 1.51e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 60.81  E-value: 1.51e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 971404011  186 ERCYDNTAGTSYVVGETWEKPYQGwMMVDCTCLGeGSGRITCTS 229
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEG-HVLQCTCLG-NRGEARCDP 42
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 97-138 1.57e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 60.81  E-value: 1.57e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 971404011   97 ETCFDKYTGSTYRVGETYERPKDSMIWDCTCIGaGRGRISCT 138
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCD 41
fn1 pfam00039
Fibronectin type I domain;
2303-2340 2.01e-11

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 60.41  E-value: 2.01e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 971404011  2303 CHDN--GVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFKC 2340
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
fn3 pfam00041
Fibronectin type III domain;
616-693 2.36e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 2.36e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011   616 PVQVIITESTnqPNSHPIQWNAPKT--SHISKYILRWRPKISGRHWKEATIPGHLNSYTISGLKPGVVYEGQLISVQQHG 693
Cdd:pfam00041    3 PSNLTVTDVT--STSLTVSWTPPPDgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1454-1532 2.39e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.86  E-value: 2.39e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011   1454 DSPTGLDFSDITANSFTVHWIAP-RATITGYKIRHHPEHGVGRPKEDRV--PPSRNSITLTNLLPGTEYVVSIIAVNGRE 1530
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 971404011   1531 ES 1532
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1179-1269 4.32e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.36  E-value: 4.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1179 SPPTNLRLEPNPDTGILiVSWDRSTTPG--ISGYRVTTAPTNGQQGSTLEEVVGaDQTSCTFENLNPGVEYNVSVYAVKD 1256
Cdd:cd00063     2 SPPTNLRVTDVTSTSVT-LSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVTPG-SETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|...
gi 971404011 1257 DQESIPISKTITQ 1269
Cdd:cd00063    80 GGESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2000-2078 5.32e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.71  E-value: 5.32e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011   2000 DAPSNLRFLTTTTNSLLASWQPP-----RAKITGYIIRYDKPGSPAKELlpRPRPGTTEATITGLEPGTEYTIYIIAVKN 2074
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEV--NVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 971404011   2075 NQKS 2078
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1638-1716 6.92e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.32  E-value: 6.92e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011   1638 DTPSQMQVTDVQDNSISIRWLPSS-----SPVTGYRVtaVPKKGHGPTKTKNVPPDQTQVTIEGLQPTVEYMVSVYAQNQ 1712
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRV--EYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 971404011   1713 NGES 1716
Cdd:smart00060   80 AGEG 83
fn1 pfam00039
Fibronectin type I domain;
529-560 1.09e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 58.48  E-value: 1.09e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 971404011   529 TYDVNQTFHKRHDEGHMLNCTCFGQGRGRWKC 560
Cdd:pfam00039    9 FYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1728-1815 1.39e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.82  E-value: 1.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1728 DRPKGLTFTEVDVDSIKIAWESPQ---GQVTRYRVTYSSPEDGIHELLPAPGGEEDTAELHGLRPGSEYTINIVAIYDDM 1804
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 971404011 1805 ESLPLTGTQST 1815
Cdd:cd00063    82 ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1818-1889 2.21e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 59.17  E-value: 2.21e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 971404011   1818 PPPTNLKFTQVTPTSLTVNWNAPNV-RLTGYRV--RVNPKEKTGPMKEINLSPDSTSAVVSGLMVATKYEVSVYA 1889
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDdGITGYIVgyRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 53-91 4.11e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 56.96  E-value: 4.11e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 971404011   53 TCFDN--GRYYQINQQWERIYLGNTLVCTCYGGSRGFNCES 91
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDP 42
fn3 pfam00041
Fibronectin type III domain;
1728-1808 4.59e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.20  E-value: 4.59e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  1728 DRPKGLTFTEVDVDSIKIAWESP---QGQVTRYRVTYS---SPEDGIHELLPapgGEEDTAELHGLRPGSEYTINIVAIY 1801
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRpknSGEPWNEITVP---GTTTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*..
gi 971404011  1802 DDMESLP 1808
Cdd:pfam00041   78 GGGEGPP 84
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2346-2385 6.63e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 56.19  E-value: 6.63e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 971404011 2346 TCYDD--GKMYQVGEQWQKEYFGAICSCTCYGGQQGWRCDNC 2385
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
143-181 8.42e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 55.78  E-value: 8.42e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 971404011   143 CHE--GGKSYKIGDTWRRPHETGgYLLECVCLGNGKGEWTC 181
Cdd:pfam00039    1 CYDpqTGRFYQVGETWERPSQRG-HVLQCTCLGNGGGEIRC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 473-513 9.44e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 55.80  E-value: 9.44e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 971404011  473 EICTTND-GIMYRVGDQWDKQHDmGHMMRCTCVGNgRGEWTC 513
Cdd:cd00061     1 EKCFDPQtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2302-2343 9.91e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 55.80  E-value: 9.91e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 971404011 2302 WCHDN--GVNYKIGEKWDRQGEnGQMMSCTCLGNgKGEFKCEPH 2343
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1179-1260 1.29e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.85  E-value: 1.29e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011   1179 SPPTNLRLEPNPDTGILiVSWDRSTTPGISGYRVTTAPTNGQQGSTLEEV-VGADQTSCTFENLNPGVEYNVSVYAVKDD 1257
Cdd:smart00060    2 SPPSNLRVTDVTSTSVT-LSWEPPPDDGITGYIVGYRVEYREEGSEWKEVnVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 971404011   1258 QES 1260
Cdd:smart00060   81 GEG 83
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 231-275 6.24e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 53.49  E-value: 6.24e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 971404011  231 NRCNDQDTKTSYRIGDTWSKKDNrGNLLQCICTGNgRGEWKCERH 275
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1002-1073 1.40e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.77  E-value: 1.40e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 971404011   1002 DAPTNLRFINTTEHSVLVLWTRP-----RAIISGYRLTAGPTrGGQPRTYNVGPSATKYLLRNLQPGTEYTVYLVAV 1073
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREE-GSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 521-563 2.02e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 51.95  E-value: 2.02e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 971404011  521 DQCIVD--GITYDVNQTFHKRHdEGHMLNCTCFGqGRGRWKCDPV 563
Cdd:cd00061     1 EKCFDPqtGVFYRVGETWERPS-EGHVLQCTCLG-NRGEARCDPV 43
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2347-2387 2.47e-08

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 51.97  E-value: 2.47e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 971404011   2347 CYDD--GKMYQVGEQWQKEY-FGAICSCTCYGGQQG-WRCDNCRR 2387
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYeGGHVLQCTCLGGGRGeWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 141-184 3.49e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 51.56  E-value: 3.49e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 971404011  141 NRCHEG--GKSYKIGDTWRRPHEtgGYLLECVCLGNgKGEWTCKPL 184
Cdd:cd00061     1 EKCFDPqtGVFYRVGETWERPSE--GHVLQCTCLGN-RGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
54-89 6.43e-08

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 50.78  E-value: 6.43e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 971404011    54 CFDN--GRYYQINQQWERIYL-GNTLVCTCYGGSRG-FNC 89
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1910-1991 1.37e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 1.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1910 SPPRRARVTDATETTITITW---RTKTETITGFQIDAIPAASGQNPIQRTISPDVRTYTITGLQPGNDYKIYLYTLNENA 1986
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWtppEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....*
gi 971404011 1987 RSSPV 1991
Cdd:cd00063    82 ESPPS 86
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 54-94 1.95e-07

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 49.27  E-value: 1.95e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 971404011     54 CFDN--GRYYQINQQWERIYL-GNTLVCTCYGGSRG-FNCESKPE 94
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
2347-2382 3.98e-07

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 48.46  E-value: 3.98e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 971404011  2347 CYDD--GKMYQVGEQWQKEY-FGAICSCTCYGGQQG-WRC 2382
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSqRGHVLQCTCLGNGGGeIRC 40
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1730-1806 9.84e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.76  E-value: 9.84e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011   1730 PKGLTFTEVDVDSIKIAWESPQ-----GQVTRYRVTYSSPEDGIHELLPAPGgeEDTAELHGLRPGSEYTINIVAIYDDM 1804
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPS--STSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 971404011   1805 ES 1806
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
2172-2230 6.28e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 46.25  E-value: 6.28e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 971404011  2172 TISWRPLLES----TEYIISCQPVSQDEDTLQFRVPGTSSSATLTGLTRGATYNIIVEALKDH 2230
Cdd:pfam00041   17 TVSWTPPPDGngpiTGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 616-694 8.63e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.07  E-value: 8.63e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011    616 PVQVIITESTnqPNSHPIQWNAPKTSHISKYILRWRPKI--SGRHWKEATIPGHLNSYTISGLKPGVVYEGQLISVQQHG 693
Cdd:smart00060    4 PSNLRVTDVT--STSVTLSWEPPPDDGITGYIVGYRVEYreEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    .
gi 971404011    694 P 694
Cdd:smart00060   82 E 82
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1910-1985 1.75e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.30  E-value: 1.75e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 971404011   1910 SPPRRARVTDATETTITITW-RTKTETITGFQIDAIPAASGQNPIQRTI--SPDVRTYTITGLQPGNDYKIYLYTLNEN 1985
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWePPPDDGITGYIVGYRVEYREEGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 616-694 4.31e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.41  E-value: 4.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  616 PVQVIITESTnqPNSHPIQWNAPKT--SHISKYILRWRPKISGRHWKEATIPGHLNSYTISGLKPGVVYEGQLISVQQHG 693
Cdd:cd00063     4 PTNLRVTDVT--STSVTLSWTPPEDdgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  .
gi 971404011  694 P 694
Cdd:cd00063    82 E 82
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 312-349 2.12e-04

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 40.78  E-value: 2.12e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 971404011  312 HCVTD-NGVVYSLGMQWLKTQGSQQMLCTCLGN--GVSCQE 349
Cdd:cd00061     2 KCFDPqTGVFYRVGETWERPSEGHVLQCTCLGNrgEARCDP 42
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 313-352 3.16e-04

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 40.41  E-value: 3.16e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 971404011    313 CVTD-NGVVYSLGMQWLKT-QGSQQMLCTCLGNG---VSCQEIAV 352
Cdd:smart00058    1 CFDEeTGTTYRVGDTWERPyEGGHVLQCTCLGGGrgeWKCDPVPV 45
 
Name Accession Description Interval E-value
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 418-466 2.63e-23

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 94.67  E-value: 2.63e-23
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 971404011    418 GNSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTENYDADQKFGFC 466
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 smart00059
Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, ...
 358-406 5.73e-23

Fibronectin type 2 domain; One of three types of internal repeat within the plasma protein, fibronectin. Also occurs in coagulation factor XII, 2 type IV collagenases, PDC-109, and cation-independent mannose-6-phosphate and secretory phospholipase A2 receptors. In fibronectin, PDC-109, and the collagenases, this domain contributes to collagen-binding function.


Pssm-ID: 128373  Cd Length: 49  Bit Score: 93.52  E-value: 5.73e-23
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 971404011    358 GNSDGEACVLPFTYNGRTFYSCTTEGRTDGHLWCSTTSNFEQDRRYSFC 406
Cdd:smart00059    1 GNSDGEPCVFPFIYNGKKYHDCTSEGRSDGMLWCSTTPNYDRDGKWGFC 49
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 419-466 2.26e-22

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 91.98  E-value: 2.26e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 971404011  419 NSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTENYDADQKFGFC 466
Cdd:cd00062     1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
FN2 cd00062
Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to ...
 359-406 3.89e-21

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.


Pssm-ID: 238019  Cd Length: 48  Bit Score: 88.52  E-value: 3.89e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 971404011  359 NSDGEACVLPFTYNGRTFYSCTTEGRTDGHLWCSTTSNFEQDRRYSFC 406
Cdd:cd00062     1 NSDGAPCVFPFIYRGKWYHDCTTEGSNDGKLWCSTTPNYDRDGKWGYC 48
fn3 pfam00041
Fibronectin type III domain;
1544-1625 7.75e-20

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 85.93  E-value: 7.75e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  1544 DVPRDLEVNPTSPTSLEISWDAPAV---TVRYYRITYGETGGSSPVQEFTVPGTMSRATITGLKPGVDYTITVYAVTGRG 1620
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 971404011  1621 DSPAS 1625
Cdd:pfam00041   81 EGPPS 85
fn2 pfam00040
Fibronectin type II domain;
425-466 1.40e-19

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 83.77  E-value: 1.40e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 971404011   425 CHFPFLYNNRNYTDCTSEGRRDNMKWCGTTENYDADQKFGFC 466
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn2 pfam00040
Fibronectin type II domain;
365-406 2.13e-19

Fibronectin type II domain;


Pssm-ID: 459645  Cd Length: 42  Bit Score: 83.39  E-value: 2.13e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 971404011   365 CVLPFTYNGRTFYSCTTEGRTDGHLWCSTTSNFEQDRRYSFC 406
Cdd:pfam00040    1 CVFPFKYKGKWYHTCTTDGRRSGRLWCATTANYDGDGKWGYC 42
fn3 pfam00041
Fibronectin type III domain;
1454-1534 2.68e-18

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 81.69  E-value: 2.68e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  1454 DSPTGLDFSDITANSFTVHWIAPR---ATITGYKIRHHPEHGVGRPKEDRVPPSRNSITLTNLLPGTEYVVSIIAVNGRE 1530
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 971404011  1531 ESVP 1534
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
1363-1444 5.38e-17

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 77.84  E-value: 5.38e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  1363 PPPTDLRFTNVGPDTMRVTWTAPT--SIVLSSFLVRYSPVKKEEDVAELTISPSDNVVVLTNLLPGTEYLVRVYSVAEQH 1440
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 971404011  1441 ESAP 1444
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
1638-1718 9.37e-17

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 77.07  E-value: 9.37e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  1638 DTPSQMQVTDVQDNSISIRWLPS---SSPVTGYRVTAVPKKGHGPTKTKNVPPDQTQVTIEGLQPTVEYMVSVYAQNQNG 1714
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 971404011  1715 ESLP 1718
Cdd:pfam00041   81 EGPP 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1065-1633 2.95e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 85.05  E-value: 2.95e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1065 EYTVYLVAVKEDLQSARETGVFTTYQPVGSVPPFNTEVTETSIVITWTPAPRIGFKLGVRPSQGGEAPREVISDSGSIVI 1144
Cdd:COG3401    21 TAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGS 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1145 SGLTPGVEYTYSLTVLMDGQERETPIIRRVTTPLSPPTN--LRLEPNPDTGILIVSWDRSTTPGISGYRVTTAPTNGQQG 1222
Cdd:COG3401   101 GSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGtyALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAV 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1223 STLEEVVGADQTSCTFENLNPGVEYNVSVYAVKDDQESIP---ISKTITQEVPQL-TDLSFVDITDSSIGLRWTPLNAST 1298
Cdd:COG3401   181 ATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPsneVSVTTPTTPPSApTGLTATADTPGSVTLSWDPVTESD 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1299 IIGYRI--TVVAAGESVPIfedfVDSSVGYYTVTGLEPGIDYDISVITLINGG-ESAP----TTLTQQTAVPPPTDLRFT 1371
Cdd:COG3401   261 ATGYRVyrSNSGDGPFTKV----ATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPsnvvSVTTDLTPPAAPSGLTAT 336

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1372 NVGPDTMRVTWTAPTSIVLSSFLVrYSPVKKEEDVAELTISPSDNVVVLTNLLPGTEYLVRVYSV-AEQHESAP------ 1444
Cdd:COG3401   337 AVGSSSITLSWTASSDADVTGYNV-YRSTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVdAAGNESAPseevsa 415

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1445 --LSGIQKTGLDSPTGLDFSDITANSFTVHWIAPRATITGYKIRHhpeHGVGRPKEDRVPPSRNSITLTNLLPGTEYVVS 1522
Cdd:COG3401   416 ttASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLAD---GGDTGNAVPFTTTSSTVTATTTDTTTANLSVT 492

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1523 IIAVNGREESVPLVGQQTTVSDVPRDLEVNPTSPTSLEISWDAPAVTVRYYRITYGETGGSSPVQEFTVPGTMSRATITG 1602
Cdd:COG3401   493 TGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVSGAGLGSGNLY 572

                         570       580       590
                  ....*....|....*....|....*....|.
gi 971404011 1603 LKPGVDYTITVYAVTGRGDSPASSKPVTVTY 1633
Cdd:COG3401   573 LITTLGGSLLTTTSTNTNDVAGVHGGTLLVL 603
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1544-1632 3.01e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 76.00  E-value: 3.01e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1544 DVPRDLEVNPTSPTSLEISWDAPAVT---VRYYRITYGETGGSSPVQEFTVPGTMSRATITGLKPGVDYTITVYAVTGRG 1620
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 971404011 1621 DSPASSKPVTVT 1632
Cdd:cd00063    82 ESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
1818-1898 4.32e-16

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 75.14  E-value: 4.32e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  1818 PPPTNLKFTQVTPTSLTVNWNAP---NVRLTGYRVRVNPKEKTGPMKEINLSPDSTSAVVSGLMVATKYEVSVYALKDSL 1894
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 971404011  1895 TSRP 1898
Cdd:pfam00041   81 EGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 188-232 1.96e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 72.00  E-value: 1.96e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 971404011    188 CYDNTAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNR 232
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
2258-2297 2.34e-15

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 71.58  E-value: 2.34e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 971404011  2258 CYDTYTGSFYSIGEEWERLSETGFKLWCQCLGFGSGHFRC 2297
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2258-2302 3.52e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 71.23  E-value: 3.52e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 971404011   2258 CYDTYTGSFYSIGEEWERLSETGFKLWCQCLGFGSGHFRCDSSKW 2302
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2303-2345 4.28e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 71.23  E-value: 4.28e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 971404011   2303 CHDN--GVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFKCEPHET 2345
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2000-2080 5.48e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 72.53  E-value: 5.48e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 2000 DAPSNLRFLTTTTNSLLASWQPPR---AKITGYIIRYDKPGSPAKELLPRPRPGTTEATITGLEPGTEYTIYIIAVKNNQ 2076
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 971404011 2077 KSEP 2080
Cdd:cd00063    82 ESPP 85
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 566-608 6.32e-15

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 70.46  E-value: 6.32e-15
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 971404011    566 CQDSETRTFYQIGDSWEK-YVHGVRYQCYCYGRGIGEWHCQPLQ 608
Cdd:smart00058    1 CFDEETGTTYRVGDTWERpYEGGHVLQCTCLGGGRGEWKCDPVP 44
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1498-1938 6.77e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 80.82  E-value: 6.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1498 EDRVPPSRNSITLTNLLPGTEYVVSIIAVNGREESVPLVGQQTTVSDVPRDLEVNPTSPTSLEISWDAPAVTVRYYRITY 1577
Cdd:COG3401    94 LTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPD 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1578 GETGGSSPVQEFTVPGTMSRATITGLKPGVDYTITVYAVTGRGDSPASsKPVTVTYKTEI-DTPSQMQVTDVQDNSISIR 1656
Cdd:COG3401   174 TSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPS-NEVSVTTPTTPpSAPTGLTATADTPGSVTLS 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1657 WLPSSSP-VTGYRVTAVPKKGHGPTKTKNVppDQTQVTIEGLQPTVEYMVSVYAQNQNGESLPLVETAVTNIDR-----P 1730
Cdd:COG3401   253 WDPVTESdATGYRVYRSNSGDGPFTKVATV--TTTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVVSVTTDLtppaaP 330

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1731 KGLTFTEVDVDSIKIAWE-SPQGQVTRYRVTYSSPEDGIHELLpAPGGEEDTAELHGLRPGSEYTINIVAIYDD-MESLP 1808
Cdd:COG3401   331 SGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGTYTKI-AETVTTTSYTDTGLTPGTTYYYKVTAVDAAgNESAP 409

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1809 LTGTQSTAIPPPTNLKFTQVTPTSLTVNWNAPNVRLTGYRVRVNPKEKTGPMKEI-NLSPDSTSAVVSGLMVATKYEVSV 1887
Cdd:COG3401   410 SEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTgNAVPFTTTSSTVTATTTDTTTANL 489

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 971404011 1888 YALKDSLTSRPAQGVVTTLENVSPPRRARVTDATETTITITWRTKTETITG 1938
Cdd:COG3401   490 SVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGA 540
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1174-1655 1.05e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 80.05  E-value: 1.05e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1174 VTTPLSPPTNLRLEPNPDTGILIVSWDRSTTPGISGYRVTTAPTNGQQGSTLeevVGADQTSCTFENLNPGVEYNVSVYA 1253
Cdd:COG3401    40 LAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTA---TGLTTLTGSGSVGGATNTGLTSSDE 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1254 VKDDQESIPISKTITQEVPQLTDLSFVDITDSSIGLRWTPLNASTIIGYRITVVA----AGESVPIFEDFVDSSVGYYTV 1329
Cdd:COG3401   117 VPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSpdtsATAAVATTSLTVTSTTLVDGG 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1330 TGLEPGIDYDISVITLINGGESAPT---TLTQQTAVP-PPTDLRFTNVGPDTMRVTWTAPTSIVLSSFLVRYSPVKKE-- 1403
Cdd:COG3401   197 GDIEPGTTYYYRVAATDTGGESAPSnevSVTTPTTPPsAPTGLTATADTPGSVTLSWDPVTESDATGYRVYRSNSGDGpf 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1404 EDVAELTispsDNVVVLTNLLPGTEYLVRVYSVAEQHESAPLSGI-----QKTGLDSPTGLDFSDITANSFTVHWIAPRA 1478
Cdd:COG3401   277 TKVATVT----TTSYTDTGLTNGTTYYYRVTAVDAAGNESAPSNVvsvttDLTPPAAPSGLTATAVGSSSITLSWTASSD 352

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1479 T-ITGYKIRHHPEHGVGRPKEDRVPPSrNSITLTNLLPGTE--YVVSIIAVNGREE--SVPLVGQQTTVSDVPRDLEVNP 1553
Cdd:COG3401   353 AdVTGYNVYRSTSGGGTYTKIAETVTT-TSYTDTGLTPGTTyyYKVTAVDAAGNESapSEEVSATTASAASGESLTASVD 431

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1554 TSPTSLEISWDAPAVTVRYYRITYGETGGSSPVQEFTVPGTMSRATITGLKPGVDYTITVYAVTGRGDSPASSKPVTVTY 1633
Cdd:COG3401   432 AVPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSV 511

                         490       500
                  ....*....|....*....|..
gi 971404011 1634 KTEIDTPSQMQVTDVQDNSISI 1655
Cdd:COG3401   512 IGASAAAAVGGAPDGTPNVTGA 533
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 475-513 1.73e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 69.30  E-value: 1.73e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 971404011    475 CTTND-GIMYRVGDQWDKQHDMGHMMRCTCVGNGRGEWTC 513
Cdd:smart00058    1 CFDEEtGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKC 40
fn3 pfam00041
Fibronectin type III domain;
2000-2080 2.72e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.14  E-value: 2.72e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  2000 DAPSNLRFLTTTTNSLLASWQPPR---AKITGYIIRY---DKPGSPAKELLPRPrpgTTEATITGLEPGTEYTIYIIAVK 2073
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYrpkNSGEPWNEITVPGT---TTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*..
gi 971404011  2074 NNQKSEP 2080
Cdd:pfam00041   78 GGGEGPP 84
fn1 pfam00039
Fibronectin type I domain;
233-272 3.11e-14

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 68.49  E-value: 3.11e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 971404011   233 CNDQDTKTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKC 272
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
fn1 pfam00039
Fibronectin type I domain;
188-227 3.39e-14

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 68.49  E-value: 3.39e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 971404011   188 CYDNTAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITC 227
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
fn3 pfam00041
Fibronectin type III domain;
1002-1081 3.40e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.75  E-value: 3.40e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  1002 DAPTNLRFINTTEHSVLVLWTRPR---AIISGYRLTAGPTRGGQP-RTYNVGPSATKYLLRNLQPGTEYTVYLVAVKEDL 1077
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPwNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 971404011  1078 QSAR 1081
Cdd:pfam00041   81 EGPP 84
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 233-277 5.97e-14

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 67.76  E-value: 5.97e-14
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 971404011    233 CNDQDTKTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTS 277
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1363-1442 1.31e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 68.02  E-value: 1.31e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011   1363 PPPTDLRFTNVGPDTMRVTWTAPTSIVLSSFLVRYSPVKKEED--VAELTISPSDNVVVLTNLLPGTEYLVRVYSVAEQH 1440
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGseWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 971404011   1441 ES 1442
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1638-1725 1.55e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 68.29  E-value: 1.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1638 DTPSQMQVTDVQDNSISIRWLPSS---SPVTGYRVTAVPKKGHGPTKTKNVPPDQTQVTIEGLQPTVEYMVSVYAQNQNG 1714
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 971404011 1715 ESLPLVETAVT 1725
Cdd:cd00063    82 ESPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1454-1534 2.18e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.91  E-value: 2.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1454 DSPTGLDFSDITANSFTVHWIAPRAT---ITGYKIRHHPEHGVGRPKEDRVPPSRNSITLTNLLPGTEYVVSIIAVNGRE 1530
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....
gi 971404011 1531 ESVP 1534
Cdd:cd00063    82 ESPP 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
728-1118 2.19e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 75.81  E-value: 2.19e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  728 TSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGEQNLIL 807
Cdd:COG3401    53 GTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGTATTATAVA 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  808 STSQTTAPdAPPEHSVESVDDTSIVISWSRPQAPITGYRIVYTPSVEG-SSTELNLPDTATSVTLSDLMPGVQYNISIYA 886
Cdd:COG3401   133 GGAATAGT-YALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAvATTSLTVTSTTLVDGGGDIEPGTTYYYRVAA 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  887 VEEHQESTPVfiqQETTGVPRTDEVPSPKDLQFVEVSDVKVTIMWTPPQSQ-VSGYRVEaipvNRPGQHGQRLPITRSSF 965
Cdd:COG3401   212 TDTGGESAPS---NEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVY----RSNSGDGPFTKVATVTT 284

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  966 AEVVD--LLPGTTYLFKIFAV-SHGRESKP---LTGE-QTTKLDAPTNLRFINTTEHSVLVLWT-RPRAIISGYRLTAGP 1037
Cdd:COG3401   285 TSYTDtgLTNGTTYYYRVTAVdAAGNESAPsnvVSVTtDLTPPAAPSGLTATAVGSSSITLSWTaSSDADVTGYNVYRST 364

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1038 TRGGQPRTYNVGPSATKYLLRNLQPGTEYTVYLVAVKED-LQSARETGVFTTYQPVGSVPPFNTEVTETSIVITWTPAPR 1116
Cdd:COG3401   365 SGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAgNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAA 444


                  ..
gi 971404011 1117 IG 1118
Cdd:COG3401   445 AS 446
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 527-565 2.51e-13

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 66.22  E-value: 2.51e-13
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 971404011    527 GITYDVNQTFHKRHDEGHMLNCTCFGQGRGRWKCDPVDQ 565
Cdd:smart00058    7 GTTYRVGDTWERPYEGGHVLQCTCLGGGRGEWKCDPVPV 45
fn3 pfam00041
Fibronectin type III domain;
816-887 2.91e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.05  E-value: 2.91e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 971404011   816 DAPPEHSVESVDDTSIVISWSRP---QAPITGYRIVYTPSVEGS-STELNLPDTATSVTLSDLMPGVQYNISIYAV 887
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
fn1 pfam00039
Fibronectin type I domain;
566-604 2.96e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 65.80  E-value: 2.96e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 971404011   566 CQDSETRTFYQIGDSWEK-YVHGVRYQCYCYGRGIGEWHC 604
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERpSQRGHVLQCTCLGNGGGEIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 815-903 3.79e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.14  E-value: 3.79e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  815 PDAPPEHSVESVDDTSIVISWSRPQ---APITGYRIVYTPSVEGSSTELNLPD-TATSVTLSDLMPGVQYNISIYAVEEH 890
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 971404011  891 QESTPVFIQQETT 903
Cdd:cd00063    81 GESPPSESVTVTT 93
fn1 pfam00039
Fibronectin type I domain;
475-513 3.89e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 65.41  E-value: 3.89e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 971404011   475 CTTND-GIMYRVGDQWDKQHDMGHMMRCTCVGNGRGEWTC 513
Cdd:pfam00039    1 CYDPQtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
fn1 pfam00039
Fibronectin type I domain;
99-137 8.33e-13

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 64.26  E-value: 8.33e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 971404011    99 CFDKYTGSTYRVGETYERPKDS-MIWDCTCIGAGRGRISC 137
Cdd:pfam00039    1 CYDPQTGRFYQVGETWERPSQRgHVLQCTCLGNGGGEIRC 40
fn3 pfam00041
Fibronectin type III domain;
1910-1990 8.49e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 8.49e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  1910 SPPRRARVTDATETTITITWRTKTE---TITGFQIDAIPAASGQNPIQRTISPDVRTYTITGLQPGNDYKIYLYTLNENA 1986
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 971404011  1987 RSSP 1990
Cdd:pfam00041   81 EGPP 84
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2256-2300 8.97e-13

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 64.28  E-value: 8.97e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 971404011 2256 DTCYDTYTGSFYSIGEEWERLSEtGFKLWCQCLGfGSGHFRCDSS 2300
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLG-NRGEARCDPV 43
fn3 pfam00041
Fibronectin type III domain;
1272-1354 9.45e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.90  E-value: 9.45e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  1272 PQLTDLSFVDITDSSIGLRWTPLNA--STIIGYRITVVAAGESVPIFEDFVDSSVGYYTVTGLEPGIDYDISVITLINGG 1349
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 971404011  1350 ESAPT 1354
Cdd:pfam00041   81 EGPPS 85
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 564-607 1.12e-12

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 64.28  E-value: 1.12e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 971404011  564 DQCQDSETRTFYQIGDSWEKYVHGVRYQCYCYGrGIGEWHCQPL 607
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCDPV 43
fn3 pfam00041
Fibronectin type III domain;
1179-1262 1.60e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.13  E-value: 1.60e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  1179 SPPTNLRLEPNPDTGiLIVSWDRSTTPG--ISGYRVTTAPTNGQQGSTlEEVVGADQTSCTFENLNPGVEYNVSVYAVKD 1256
Cdd:pfam00041    1 SAPSNLTVTDVTSTS-LTVSWTPPPDGNgpITGYEVEYRPKNSGEPWN-EITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78


                   ....*.
gi 971404011  1257 DQESIP 1262
Cdd:pfam00041   79 GGEGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1363-1449 1.65e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 65.21  E-value: 1.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1363 PPPTDLRFTNVGPDTMRVTWTAPTSI--VLSSFLVRYSPVKKEEDVAELTISPSDNVVVLTNLLPGTEYLVRVYSVAEQH 1440
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDggPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....*....
gi 971404011 1441 ESAPLSGIQ 1449
Cdd:cd00063    82 ESPPSESVT 90
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1818-1905 1.70e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 65.21  E-value: 1.70e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1818 PPPTNLKFTQVTPTSLTVNWNAP---NVRLTGYRVRVNPKEKTGPMKEINLSPDSTSAVVSGLMVATKYEVSVYALKDSL 1894
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 971404011 1895 TSRPAQGVVTT 1905
Cdd:cd00063    82 ESPPSESVTVT 92
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1700-2072 1.82e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 72.73  E-value: 1.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1700 TVEYMVSVYAQNQNGESLPLVETAVTNIDRPKGLTFTEVDVDSIKIAWESPQGQVTRY-----RVTYSSPEDGIHELLPA 1774
Cdd:COG3401    21 TAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGvaavaVAAAPPTATGLTTLTGS 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1775 PGGEEDTAELHGLRPGSEYTINIVAIYDDMESLPLTGTQSTAipPPTNLKFTQVTPTSLTVNWNAPNVRLTGYRVRVNPK 1854
Cdd:COG3401   101 GSVGGATNTGLTSSDEVPSPAVGTATTATAVAGGAATAGTYA--LGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATA 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1855 EKTGPMKEINlsPDSTSAVVSGLMVATKYEVSVYALKDSLTSRPAQGV--VTTLENVSPPRRARVTDATETTITITWRTK 1932
Cdd:COG3401   179 AVATTSLTVT--STTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVsvTTPTTPPSAPTGLTATADTPGSVTLSWDPV 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1933 TET-ITGFQIDAIPAASGQ-NPIQRTISPdvrTYTITGLQPGNDYKIYLYTLNENARSSP--VVIDASTAI---DAPSNL 2005
Cdd:COG3401   257 TESdATGYRVYRSNSGDGPfTKVATVTTT---SYTDTGLTNGTTYYYRVTAVDAAGNESApsNVVSVTTDLtppAAPSGL 333

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 971404011 2006 RFLTTTTNSLLASWQPPR-AKITGYIIRYDKPGSPAKELLPRPrPGTTEATITGLEPGTEYTIYIIAV 2072
Cdd:COG3401   334 TATAVGSSSITLSWTASSdADVTGYNVYRSTSGGGTYTKIAET-VTTTSYTDTGLTPGTTYYYKVTAV 400
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1546-1622 2.85e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 64.56  E-value: 2.85e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011   1546 PRDLEVNPTSPTSLEISWDAPAVT-----VRYYRITYGETGGSspVQEFTVPGTMSRATITGLKPGVDYTITVYAVTGRG 1620
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSE--WKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 971404011   1621 DS 1622
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
731-802 3.29e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 64.36  E-value: 3.29e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 971404011   731 SVTEITASSFVVSW---VSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGE 802
Cdd:pfam00041    7 TVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGE 81
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 99-142 3.64e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 62.75  E-value: 3.64e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 971404011     99 CFDKYTGSTYRVGETYERPKDS-MIWDCTCIGAGRGRISCTIANR 142
Cdd:smart00058    1 CFDEETGTTYRVGDTWERPYEGgHVLQCTCLGGGRGEWKCDPVPV 45
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 815-893 4.55e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 63.79  E-value: 4.55e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011    815 PDAPPEHSVESVDDTSIVISWSRPQ-----APITGYRIVYTPSvEGSSTELNLPDTATSVTLSDLMPGVQYNISIYAVEE 889
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREE-GSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 971404011    890 HQES 893
Cdd:smart00060   80 AGEG 83
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 143-186 8.77e-12

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 61.60  E-value: 8.77e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 971404011    143 CHEG--GKSYKIGDTWRRPHEtGGYLLECVCLGNGKGEWTCKPLAE 186
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYE-GGHVLQCTCLGGGRGEWKCDPVPV 45
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1002-1088 1.07e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.90  E-value: 1.07e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1002 DAPTNLRFINTTEHSVLVLWTRPR---AIISGYRLTAGPTRGGQPRTYNVGP-SATKYLLRNLQPGTEYTVYLVAVKEDL 1077
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|..
gi 971404011 1078 QSAR-ETGVFTT 1088
Cdd:cd00063    82 ESPPsESVTVTT 93
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 186-229 1.51e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 60.81  E-value: 1.51e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 971404011  186 ERCYDNTAGTSYVVGETWEKPYQGwMMVDCTCLGeGSGRITCTS 229
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEG-HVLQCTCLG-NRGEARCDP 42
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 97-138 1.57e-11

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 60.81  E-value: 1.57e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 971404011   97 ETCFDKYTGSTYRVGETYERPKDSMIWDCTCIGaGRGRISCT 138
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSEGHVLQCTCLG-NRGEARCD 41
fn1 pfam00039
Fibronectin type I domain;
2303-2340 2.01e-11

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 60.41  E-value: 2.01e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 971404011  2303 CHDN--GVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFKC 2340
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
fn3 pfam00041
Fibronectin type III domain;
616-693 2.36e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 2.36e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011   616 PVQVIITESTnqPNSHPIQWNAPKT--SHISKYILRWRPKISGRHWKEATIPGHLNSYTISGLKPGVVYEGQLISVQQHG 693
Cdd:pfam00041    3 PSNLTVTDVT--STSLTVSWTPPPDgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1454-1532 2.39e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.86  E-value: 2.39e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011   1454 DSPTGLDFSDITANSFTVHWIAP-RATITGYKIRHHPEHGVGRPKEDRV--PPSRNSITLTNLLPGTEYVVSIIAVNGRE 1530
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpDDGITGYIVGYRVEYREEGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 971404011   1531 ES 1532
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1179-1269 4.32e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.36  E-value: 4.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1179 SPPTNLRLEPNPDTGILiVSWDRSTTPG--ISGYRVTTAPTNGQQGSTLEEVVGaDQTSCTFENLNPGVEYNVSVYAVKD 1256
Cdd:cd00063     2 SPPTNLRVTDVTSTSVT-LSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVTPG-SETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|...
gi 971404011 1257 DQESIPISKTITQ 1269
Cdd:cd00063    80 GGESPPSESVTVT 92
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
715-1053 4.85e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 68.11  E-value: 4.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  715 VSGETTLLPPMVATSESVTEITASSFVVSWVSASDT-VSGFRVEYELSEEGdEPQYLDlPSTATSVNIPDLLPGRKY--- 790
Cdd:COG3401   224 VSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDG-PFTKVA-TVTTTSYTDTGLTNGTTYyyr 301

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  791 IVNVYQISEEGEQNLILS-TSQTTAPDAPPEHSVESVDDTSIVISWS-RPQAPITGYRIVYTPSVEGSSTELNLPDTATS 868
Cdd:COG3401   302 VTAVDAAGNESAPSNVVSvTTDLTPPAAPSGLTATAVGSSSITLSWTaSSDADVTGYNVYRSTSGGGTYTKIAETVTTTS 381

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  869 VTLSDLMPGVQYNISIYAV----EEHQESTPVFIQQETTGVPRTDEVPSPKDLQFVEVSDVKVTIMWTPPQSQVSGYRVE 944
Cdd:COG3401   382 YTDTGLTPGTTYYYKVTAVdaagNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADG 461

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  945 AIPVNRPgqhgqrlPITRSSFAEVVDLLPGTTYLFKIFAVSH--GRESKPLTGEQTTKLDAPTNLRFINTTEHSVLVLWT 1022
Cdd:COG3401   462 GDTGNAV-------PFTTTSSTVTATTTDTTTANLSVTTGSLvgGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGAS 534

                         330       340       350
                  ....*....|....*....|....*....|.
gi 971404011 1023 RPRAIISGYRLTAGPTRGGQPRTYNVGPSAT 1053
Cdd:COG3401   535 PVTVGASTGDVLITDLVSLTTSASSSVSGAG 565
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2000-2078 5.32e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.71  E-value: 5.32e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011   2000 DAPSNLRFLTTTTNSLLASWQPP-----RAKITGYIIRYDKPGSPAKELlpRPRPGTTEATITGLEPGTEYTIYIIAVKN 2074
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEV--NVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 971404011   2075 NQKS 2078
Cdd:smart00060   80 AGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1638-1716 6.92e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 60.32  E-value: 6.92e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011   1638 DTPSQMQVTDVQDNSISIRWLPSS-----SPVTGYRVtaVPKKGHGPTKTKNVPPDQTQVTIEGLQPTVEYMVSVYAQNQ 1712
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRV--EYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 971404011   1713 NGES 1716
Cdd:smart00060   80 AGEG 83
fn3 pfam00041
Fibronectin type III domain;
912-992 6.98e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.51  E-value: 6.98e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011   912 PSPKDLQFVEVSDVKVTIMWTPP---QSQVSGYRVEAIPVNRpGQHGQRLPITRS-SFAEVVDLLPGTTYLFKIFAVSHG 987
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNS-GEPWNEITVPGTtTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*
gi 971404011   988 RESKP 992
Cdd:pfam00041   80 GEGPP 84
fn1 pfam00039
Fibronectin type I domain;
529-560 1.09e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 58.48  E-value: 1.09e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 971404011   529 TYDVNQTFHKRHDEGHMLNCTCFGQGRGRWKC 560
Cdd:pfam00039    9 FYQVGETWERPSQRGHVLQCTCLGNGGGEIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1728-1815 1.39e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 59.82  E-value: 1.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1728 DRPKGLTFTEVDVDSIKIAWESPQ---GQVTRYRVTYSSPEDGIHELLPAPGGEEDTAELHGLRPGSEYTINIVAIYDDM 1804
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 971404011 1805 ESLPLTGTQST 1815
Cdd:cd00063    82 ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1818-1889 2.21e-10

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 59.17  E-value: 2.21e-10
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 971404011   1818 PPPTNLKFTQVTPTSLTVNWNAPNV-RLTGYRV--RVNPKEKTGPMKEINLSPDSTSAVVSGLMVATKYEVSVYA 1889
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDdGITGYIVgyRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 53-91 4.11e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 56.96  E-value: 4.11e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 971404011   53 TCFDN--GRYYQINQQWERIYLGNTLVCTCYGGSRGFNCES 91
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDP 42
fn3 pfam00041
Fibronectin type III domain;
1728-1808 4.59e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.20  E-value: 4.59e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  1728 DRPKGLTFTEVDVDSIKIAWESP---QGQVTRYRVTYS---SPEDGIHELLPapgGEEDTAELHGLRPGSEYTINIVAIY 1801
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRpknSGEPWNEITVP---GTTTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*..
gi 971404011  1802 DDMESLP 1808
Cdd:pfam00041   78 GGGEGPP 84
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2346-2385 6.63e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 56.19  E-value: 6.63e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 971404011 2346 TCYDD--GKMYQVGEQWQKEYFGAICSCTCYGGQQGWRCDNC 2385
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSEGHVLQCTCLGNRGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
143-181 8.42e-10

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 55.78  E-value: 8.42e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 971404011   143 CHE--GGKSYKIGDTWRRPHETGgYLLECVCLGNGKGEWTC 181
Cdd:pfam00039    1 CYDpqTGRFYQVGETWERPSQRG-HVLQCTCLGNGGGEIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1275-1360 8.62e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.51  E-value: 8.62e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1275 TDLSFVDITDSSIGLRWTP--LNASTIIGYRITVVAAGESVPIFEDFVDSSVGYYTVTGLEPGIDYDISVITLINGGESA 1352
Cdd:cd00063     5 TNLRVTDVTSTSVTLSWTPpeDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESP 84


                  ....*...
gi 971404011 1353 PTTLTQQT 1360
Cdd:cd00063    85 PSESVTVT 92
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 473-513 9.44e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 55.80  E-value: 9.44e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 971404011  473 EICTTND-GIMYRVGDQWDKQHDmGHMMRCTCVGNgRGEWTC 513
Cdd:cd00061     1 EKCFDPQtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARC 40
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 2302-2343 9.91e-10

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 55.80  E-value: 9.91e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 971404011 2302 WCHDN--GVNYKIGEKWDRQGEnGQMMSCTCLGNgKGEFKCEPH 2343
Cdd:cd00061     2 KCFDPqtGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1179-1260 1.29e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.85  E-value: 1.29e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011   1179 SPPTNLRLEPNPDTGILiVSWDRSTTPGISGYRVTTAPTNGQQGSTLEEV-VGADQTSCTFENLNPGVEYNVSVYAVKDD 1257
Cdd:smart00060    2 SPPSNLRVTDVTSTSVT-LSWEPPPDDGITGYIVGYRVEYREEGSEWKEVnVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 971404011   1258 QES 1260
Cdd:smart00060   81 GEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 914-999 2.57e-09

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 56.35  E-value: 2.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  914 PKDLQFVEVSDVKVTIMWTPPQ---SQVSGYRVEAIPVNRPGQHGQRLPITRSSFAEVVDLLPGTTYLFKIFAVSHGRES 990
Cdd:cd00063     4 PTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGES 83


                  ....*....
gi 971404011  991 KPLTGEQTT 999
Cdd:cd00063    84 PPSESVTVT 92
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 231-275 6.24e-09

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 53.49  E-value: 6.24e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 971404011  231 NRCNDQDTKTSYRIGDTWSKKDNrGNLLQCICTGNgRGEWKCERH 275
Cdd:cd00061     1 EKCFDPQTGVFYRVGETWERPSE-GHVLQCTCLGN-RGEARCDPV 43
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1002-1073 1.40e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.77  E-value: 1.40e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 971404011   1002 DAPTNLRFINTTEHSVLVLWTRP-----RAIISGYRLTAGPTrGGQPRTYNVGPSATKYLLRNLQPGTEYTVYLVAV 1073
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREE-GSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 521-563 2.02e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 51.95  E-value: 2.02e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 971404011  521 DQCIVD--GITYDVNQTFHKRHdEGHMLNCTCFGqGRGRWKCDPV 563
Cdd:cd00061     1 EKCFDPqtGVFYRVGETWERPS-EGHVLQCTCLG-NRGEARCDPV 43
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 2347-2387 2.47e-08

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 51.97  E-value: 2.47e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 971404011   2347 CYDD--GKMYQVGEQWQKEY-FGAICSCTCYGGQQG-WRCDNCRR 2387
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYeGGHVLQCTCLGGGRGeWKCDPVPV 45
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 141-184 3.49e-08

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 51.56  E-value: 3.49e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 971404011  141 NRCHEG--GKSYKIGDTWRRPHEtgGYLLECVCLGNgKGEWTCKPL 184
Cdd:cd00061     1 EKCFDPqtGVFYRVGETWERPSE--GHVLQCTCLGN-RGEARCDPV 43
fn1 pfam00039
Fibronectin type I domain;
54-89 6.43e-08

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 50.78  E-value: 6.43e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 971404011    54 CFDN--GRYYQINQQWERIYL-GNTLVCTCYGGSRG-FNC 89
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSQrGHVLQCTCLGNGGGeIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1910-1991 1.37e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 1.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1910 SPPRRARVTDATETTITITW---RTKTETITGFQIDAIPAASGQNPIQRTISPDVRTYTITGLQPGNDYKIYLYTLNENA 1986
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWtppEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  ....*
gi 971404011 1987 RSSPV 1991
Cdd:cd00063    82 ESPPS 86
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1826-2072 1.75e-07

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 56.88  E-value: 1.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1826 TQVTPTSLTVNWNAPNVRLTGYRVRVNPKEKTGPM-KEINLSPDSTSAVVsglMVATKYEVSVYALKDS--LTSRPAQGV 1902
Cdd:COG4733   456 QSVAGRTLTVSTAYSETPEAGAVWAFGPDELETQLfRVVSIEENEDGTYT---ITAVQHAPEKYAAIDAgaFDDVPPQWP 532

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1903 VTTLEnVSPPRRARVTDATETTITITWRTKTETITgFQIDAIPAASGQNPIQRTISPdvrTYTITGLQPGnDYKIYLYTL 1982
Cdd:COG4733   533 PVNVT-TSESLSVVAQGTAVTTLTVSWDAPAGAVA-YEVEWRRDDGNWVSVPRTSGT---SFEVPGIYAG-DYEVRVRAI 606

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1983 NENARSSPVVIDASTAI----DAPSNLRFLTTTTNSLLA--SW-QPPRAKITGYIIRYDKPGSPAKELLPRPRPGTTEAT 2055
Cdd:COG4733   607 NALGVSSAWAASSETTVtgktAPPPAPTGLTATGGLGGItlSWsFPVDADTLRTEIRYSTTGDWASATVAQALYPGNTYT 686

                         250
                  ....*....|....*..
gi 971404011 2056 ITGLEPGTEYTIYIIAV 2072
Cdd:COG4733   687 LAGLKAGQTYYYRARAV 703
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 54-94 1.95e-07

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 49.27  E-value: 1.95e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 971404011     54 CFDN--GRYYQINQQWERIYL-GNTLVCTCYGGSRG-FNCESKPE 94
Cdd:smart00058    1 CFDEetGTTYRVGDTWERPYEgGHVLQCTCLGGGRGeWKCDPVPV 45
fn1 pfam00039
Fibronectin type I domain;
2347-2382 3.98e-07

Fibronectin type I domain;


Pssm-ID: 459644  Cd Length: 40  Bit Score: 48.46  E-value: 3.98e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 971404011  2347 CYDD--GKMYQVGEQWQKEY-FGAICSCTCYGGQQG-WRC 2382
Cdd:pfam00039    1 CYDPqtGRFYQVGETWERPSqRGHVLQCTCLGNGGGeIRC 40
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 731-813 3.98e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 3.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  731 SVTEITASSFVVSWVSASDT---VSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEEGEQNLIL 807
Cdd:cd00063     8 RVTDVTSTSVTLSWTPPEDDggpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSE 87


                  ....*.
gi 971404011  808 STSQTT 813
Cdd:cd00063    88 SVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 912-990 6.47e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.15  E-value: 6.47e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011    912 PSPKDLQFVEVSDVKVTIMWTPPQSQVS-GYRVEAIPVNRPGQHGQR--LPITRSSFAEVVDLLPGTTYLFKIFAVSHGR 988
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGItGYIVGYRVEYREEGSEWKevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 971404011    989 ES 990
Cdd:smart00060   82 EG 83
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
723-903 8.21e-07

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 54.57  E-value: 8.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  723 PPMVATSESVTEIT----ASSFVVSWVSASDTVSgfrveYELSEEGDEPQYLDLPST-ATSVNIPDLLPGRkYIVNVYQI 797
Cdd:COG4733   533 PVNVTTSESLSVVAqgtaVTTLTVSWDAPAGAVA-----YEVEWRRDDGNWVSVPRTsGTSFEVPGIYAGD-YEVRVRAI 606

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  798 SEEGEQNLILSTSQTT------APDAPPEHSVESVDDtSIVISWSRPQ-APITGYRIVYTPSVEGSSTELNLPD-TATSV 869
Cdd:COG4733   607 NALGVSSAWAASSETTvtgktaPPPAPTGLTATGGLG-GITLSWSFPVdADTLRTEIRYSTTGDWASATVAQALyPGNTY 685

                         170       180       190
                  ....*....|....*....|....*....|....
gi 971404011  870 TLSDLMPGVQYNISIYAVEEHQESTPVFIQQETT 903
Cdd:COG4733   686 TLAGLKAGQTYYYRARAVDRSGNVSAWWVSGQAS 719
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1730-1806 9.84e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 48.76  E-value: 9.84e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011   1730 PKGLTFTEVDVDSIKIAWESPQ-----GQVTRYRVTYSSPEDGIHELLPAPGgeEDTAELHGLRPGSEYTINIVAIYDDM 1804
Cdd:smart00060    4 PSNLRVTDVTSTSVTLSWEPPPddgitGYIVGYRVEYREEGSEWKEVNVTPS--STSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 971404011   1805 ES 1806
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1275-1351 2.47e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.61  E-value: 2.47e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 971404011   1275 TDLSFVDITDSSIGLRWTPLNASTIIGYRITVVAAGESVPIFEDFVDSSVGY--YTVTGLEPGIDYDISVITLINGGES 1351
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSStsYTLTGLKPGTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
1096-1158 2.61e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.41  E-value: 2.61e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 971404011  1096 PPFN---TEVTETSIVITWTPAPR-----IGFKLGVRPSQGGEAPREVI--SDSGSIVISGLTPGVEYTYSLT 1158
Cdd:pfam00041    2 APSNltvTDVTSTSLTVSWTPPPDgngpiTGYEVEYRPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQ 74
fn3 pfam00041
Fibronectin type III domain;
2172-2230 6.28e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 46.25  E-value: 6.28e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 971404011  2172 TISWRPLLES----TEYIISCQPVSQDEDTLQFRVPGTSSSATLTGLTRGATYNIIVEALKDH 2230
Cdd:pfam00041   17 TVSWTPPPDGngpiTGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 731-795 8.46e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.07  E-value: 8.46e-06
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 971404011    731 SVTEITASSFVVSW-VSASDTVSGFRVEYELSEEGDEPQYLDLPSTA--TSVNIPDLLPGRKYIVNVY 795
Cdd:smart00060    8 RVTDVTSTSVTLSWePPPDDGITGYIVGYRVEYREEGSEWKEVNVTPssTSYTLTGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 616-694 8.63e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.07  E-value: 8.63e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011    616 PVQVIITESTnqPNSHPIQWNAPKTSHISKYILRWRPKI--SGRHWKEATIPGHLNSYTISGLKPGVVYEGQLISVQQHG 693
Cdd:smart00060    4 PSNLRVTDVT--STSVTLSWEPPPDDGITGYIVGYRVEYreEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    .
gi 971404011    694 P 694
Cdd:smart00060   82 E 82
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
568-886 1.36e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 50.39  E-value: 1.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  568 DSETRTFYQIGDSWEKYVHGVRYQCY--CYGRGIGEWHCQPLQAYAGATGPVQVI-ITESTNQPNSHPIQWNAPKTSHIS 644
Cdd:COG3401   183 TSLTVTSTTLVDGGGDIEPGTTYYYRvaATDTGGESAPSNEVSVTTPTTPPSAPTgLTATADTPGSVTLSWDPVTESDAT 262

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  645 KYILRWRPKISGRHWKEATIPGhlNSYTISGLKPGVVYEGQLISVQQHGpkevtrfdftttsTTAVTSNTVSGETTLLPP 724
Cdd:COG3401   263 GYRVYRSNSGDGPFTKVATVTT--TSYTDTGLTNGTTYYYRVTAVDAAG-------------NESAPSNVVSVTTDLTPP 327

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  725 MVATSESVTEITASSFVVSWVSASDT-VSGFRVEYELSEEGdEPQYLDLPSTATSVNIPDLLPGRKY---IVNVYQISEE 800
Cdd:COG3401   328 AAPSGLTATAVGSSSITLSWTASSDAdVTGYNVYRSTSGGG-TYTKIAETVTTTSYTDTGLTPGTTYyykVTAVDAAGNE 406

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  801 GEQNLILSTSQTTAPDAPPEHSVESVDDTSIVISWSRPQAPITGYRIV-YTPSVEGSSTELNLPDTATSVTLSDLMPGVQ 879
Cdd:COG3401   407 SAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSaAVLADGGDTGNAVPFTTTSSTVTATTTDTTT 486


                  ....*..
gi 971404011  880 YNISIYA 886
Cdd:COG3401   487 ANLSVTT 493
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1910-1985 1.75e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.30  E-value: 1.75e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 971404011   1910 SPPRRARVTDATETTITITW-RTKTETITGFQIDAIPAASGQNPIQRTI--SPDVRTYTITGLQPGNDYKIYLYTLNEN 1985
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWePPPDDGITGYIVGYRVEYREEGSEWKEVnvTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1464-1622 2.23e-05

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 49.94  E-value: 2.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1464 ITANSFTVHWIAPRATITgYKIRHHPEHGVGRPKEDRvppSRNSITLTNLLPGTeYVVSIIAVNGRE-ESVPLVGQQTTV 1542
Cdd:COG4733   549 TAVTTLTVSWDAPAGAVA-YEVEWRRDDGNWVSVPRT---SGTSFEVPGIYAGD-YEVRVRAINALGvSSAWAASSETTV 623

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1543 SDvprdLEVNPTSPTSLE---------ISWDAPA-VTVRYYRITYGETGGSSPVQEFTVPGTMSRATITGLKPGVDYTIT 1612
Cdd:COG4733   624 TG----KTAPPPAPTGLTatgglggitLSWSFPVdADTLRTEIRYSTTGDWASATVAQALYPGNTYTLAGLKAGQTYYYR 699

                         170
                  ....*....|
gi 971404011 1613 VYAVTGRGDS 1622
Cdd:COG4733   700 ARAVDRSGNV 709
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 616-694 4.31e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.41  E-value: 4.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  616 PVQVIITESTnqPNSHPIQWNAPKT--SHISKYILRWRPKISGRHWKEATIPGHLNSYTISGLKPGVVYEGQLISVQQHG 693
Cdd:cd00063     4 PTNLRVTDVT--STSVTLSWTPPEDdgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                  .
gi 971404011  694 P 694
Cdd:cd00063    82 E 82
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1096-1159 1.26e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.60  E-value: 1.26e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 971404011   1096 PPFN---TEVTETSIVITWTP-------APRIGFKLGVRPSQGGEAPREVISDSGSIVISGLTPGVEYTYSLTV 1159
Cdd:smart00060    3 PPSNlrvTDVTSTSVTLSWEPppddgitGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
943-1443 1.62e-04

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 47.25  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011  943 VEAIPVNRPGQHGQR--------LPITRS-SFA---EVVDLLPGTtylfkIFAVSHGRESKPLTG-------EQTTKLDA 1003
Cdd:COG4733   356 LTAPGCTSRGQAQREgrwalltnRYRTRTvTFSvglDGLVATPGD-----VIAVADDVLAGRRIGgrvssvdGRVVTLDR 430

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1004 PT---------NLRFINTTEHSVLVLWTRPRAIISGYRLTAGPTRGGqprTYNVGPSATK---YLLRNLQPGTEYTVYLV 1071
Cdd:COG4733   431 PVtmeagdrylRVRLPDGTSVARTVQSVAGRTLTVSTAYSETPEAGA---VWAFGPDELEtqlFRVVSIEENEDGTYTIT 507

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1072 AVK--EDLQSARETGVFTtyqPVGSVPPFNTEVT------------ETSIVITWTPAP-RIGFKLGVRPSQGG--EAPRe 1134
Cdd:COG4733   508 AVQhaPEKYAAIDAGAFD---DVPPQWPPVNVTTseslsvvaqgtaVTTLTVSWDAPAgAVAYEVEWRRDDGNwvSVPR- 583

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1135 viSDSGSIVISGLTPGveyTYSLTV---LMDGQERETPIIRRVT-----TPLSPPTNLRLEPNPDtGILIvSWDRSTTPG 1206
Cdd:COG4733   584 --TSGTSFEVPGIYAG---DYEVRVraiNALGVSSAWAASSETTvtgktAPPPAPTGLTATGGLG-GITL-SWSFPVDAD 656

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1207 ISGYRVTTAPTNGQQGSTLEEVVGAdQTSCTFENLNPGVEYNVSVYAVKD--DQESIPISKTITQEVPQLTDLSFVDITD 1284
Cdd:COG4733   657 TLRTEIRYSTTGDWASATVAQALYP-GNTYTLAGLKAGQTYYYRARAVDRsgNVSAWWVSGQASADAAGILDAITGQILE 735

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1285 SSIG--LRWTPLNAS---TIIGYRITVVAAGESVPIFEDFVDSSVGY-----YTVTGLEPGIDYDISVITLINGGESAPT 1354
Cdd:COG4733   736 TELGqeLDAIIQNATvaeVVAATVTDVTAQIDTAVLFAGVATAAAIGaearvAATVAESATAAAATGTAADAAGDASGGV 815

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1355 TLTQ-QTAVPPPTDLRFTNVGPDTMRVTWTAPTSIVLSSflVRYSPVKKEEDVAELTISPSDNVVVLTNLLPGTEYLVRV 1433
Cdd:COG4733   816 TAGTsGTTGAGDTAASTTRVAAAVVLAGVVVYGDAIIES--GNTGDIVATGDIASAAAGAVATTVSGTTAADVSAVADST 893

                         570
                  ....*....|
gi 971404011 1434 YSVAEQHESA 1443
Cdd:COG4733   894 AASLTAIVIA 903
FN1 cd00061
Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. ...
 312-349 2.12e-04

Fibronectin type 1 domain, approximately 40 residue long with two conserved disulfide bridges. FN1 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. FN1 domains also found in coagulation factor XII, HGF activator, and tissue-type plasminogen activator. In tissue plasminogen activator, FN1 domains may form functional fibrin-binding units with EGF-like domains C-terminal to FN1.


Pssm-ID: 238018  Cd Length: 43  Bit Score: 40.78  E-value: 2.12e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 971404011  312 HCVTD-NGVVYSLGMQWLKTQGSQQMLCTCLGN--GVSCQE 349
Cdd:cd00061     2 KCFDPqTGVFYRVGETWERPSEGHVLQCTCLGNrgEARCDP 42
FN1 smart00058
Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, ...
 313-352 3.16e-04

Fibronectin type 1 domain; One of three types of internal repeat within the plasma protein, fibronectin. Found also in coagulation factor XII, HGF activator and tissue-type plasminogen activator. In t-PA and fibronectin, this domain type contributes to fibrin-binding.


Pssm-ID: 214494  Cd Length: 45  Bit Score: 40.41  E-value: 3.16e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 971404011    313 CVTD-NGVVYSLGMQWLKT-QGSQQMLCTCLGNG---VSCQEIAV 352
Cdd:smart00058    1 CFDEeTGTTYRVGDTWERPyEGGHVLQCTCLGGGrgeWKCDPVPV 45
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1786-2009 1.07e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 44.55  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1786 GLRPGSEYTINIVAIYDDMESLPLTGTQSTAIPPPTNLkFTQVTP-------------TSLTVNWNAPNVRlTGYRVRVn 1852
Cdd:COG4733   495 SIEENEDGTYTITAVQHAPEKYAAIDAGAFDDVPPQWP-PVNVTTseslsvvaqgtavTTLTVSWDAPAGA-VAYEVEW- 571

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1853 pkeKTGPMKEINLSPDSTSAVVSGLMVATKYEVSVYAL-KDSLTSRPAQGVVTTLE-NVSPPrrARVTDATETT----IT 1926
Cdd:COG4733   572 ---RRDDGNWVSVPRTSGTSFEVPGIYAGDYEVRVRAInALGVSSAWAASSETTVTgKTAPP--PAPTGLTATGglggIT 646

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1927 ITWRTKTET-ITGFQIDAIPAASGQNPIQRTISPDVRTYTITGLQPGNDYKIYLYTLNENARSSPVVIDASTAIDAPSNL 2005
Cdd:COG4733   647 LSWSFPVDAdTLRTEIRYSTTGDWASATVAQALYPGNTYTLAGLKAGQTYYYRARAVDRSGNVSAWWVSGQASADAAGIL 726


                  ....
gi 971404011 2006 RFLT 2009
Cdd:COG4733   727 DAIT 730
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1540-1728 1.32e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 44.17  E-value: 1.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1540 TTVSDVPRDLEVNPTSPTSLEISWDAPAVTVRYYrITYgETGGSSPVQEFTVPGTmsRATITGLKPGvDYTITVYAVT-- 1617
Cdd:COG4733   535 NVTTSESLSVVAQGTAVTTLTVSWDAPAGAVAYE-VEW-RRDDGNWVSVPRTSGT--SFEVPGIYAG-DYEVRVRAINal 609

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1618 GRGDSPASSKPVTVTYKteIDTPSQMQ--VTDVQDNSISIRW-LPSSSPVTGYRVTAVPKKGHGPTKTKNVPPDQTQVTI 1694
Cdd:COG4733   610 GVSSAWAASSETTVTGK--TAPPPAPTglTATGGLGGITLSWsFPVDADTLRTEIRYSTTGDWASATVAQALYPGNTYTL 687

                         170       180       190
                  ....*....|....*....|....*....|....
gi 971404011 1695 EGLQPTVEYMVSVYAQNQNGESLPLVETAVTNID 1728
Cdd:COG4733   688 AGLKAGQTYYYRARAVDRSGNVSAWWVSGQASAD 721
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1100-1158 2.76e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.02  E-value: 2.76e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 971404011 1100 TEVTETSIVITWTP-----APRIGFKLGVRPSQGGEaPREV---ISDSGSIVISGLTPGVEYTYSLT 1158
Cdd:cd00063    10 TDVTSTSVTLSWTPpeddgGPITGYVVEYREKGSGD-WKEVevtPGSETSYTLTGLKPGTEYEFRVR 75
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1297-1671 2.86e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 43.01  E-value: 2.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1297 STIIGYRITVVAAGESVPIFEDFV-----DSSVGYYTVTGLEP---------GIDYDISVITLINGGesaptTLTQQTAV 1362
Cdd:COG4733   456 QSVAGRTLTVSTAYSETPEAGAVWafgpdELETQLFRVVSIEEnedgtytitAVQHAPEKYAAIDAG-----AFDDVPPQ 530

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1363 PPPTDLRFT--------NVGPDTMRVTWTAPTSIVlsSFLVRYSPVKKEEDVAELTISPSDNVvvlTNLLPGTeYLVRVY 1434
Cdd:COG4733   531 WPPVNVTTSeslsvvaqGTAVTTLTVSWDAPAGAV--AYEVEWRRDDGNWVSVPRTSGTSFEV---PGIYAGD-YEVRVR 604

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1435 SVAEQHESAPLS---GIQKTGLDS----PTGLDFSDITaNSFTVHW-IAPRATITGYKIRHHPEHGVGRPKEDRVPPSRN 1506
Cdd:COG4733   605 AINALGVSSAWAassETTVTGKTApppaPTGLTATGGL-GGITLSWsFPVDADTLRTEIRYSTTGDWASATVAQALYPGN 683

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1507 SITLTNLLPGTEYVVSIIAVN--GREESVPLVGQQTTVSDVPRD--LEVNPTSPTSLEISWDAPAVTVRYYRITYGETGG 1582
Cdd:COG4733   684 TYTLAGLKAGQTYYYRARAVDrsGNVSAWWVSGQASADAAGILDaiTGQILETELGQELDAIIQNATVAEVVAATVTDVT 763

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1583 SSPVQEFTVPGTMSRATITGLKPGVDYTITVYAVTGRGDSPASSKPVTVTYKTEIDTPSQmQVTDVQDNSISIRWLPSSS 1662
Cdd:COG4733   764 AQIDTAVLFAGVATAAAIGAEARVAATVAESATAAAATGTAADAAGDASGGVTAGTSGTT-GAGDTAASTTRVAAAVVLA 842


                  ....*....
gi 971404011 1663 PVTGYRVTA 1671
Cdd:COG4733   843 GVVVYGDAI 851
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
1516-2001 2.96e-03

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 43.01  E-value: 2.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1516 GTEYVVSIIAVNGREESVPlvgqqTTVSDVPRDLEVnptsptsleISWDAPAVTVRYYRITygetgGSSPVQEFTVpgtm 1595
Cdd:COG4733   448 GTSVARTVQSVAGRTLTVS-----TAYSETPEAGAV---------WAFGPDELETQLFRVV-----SIEENEDGTY---- 504

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1596 sraTITGLK--PGVDYTITVYAVTGRGDSPAsskPVTVTYKTEIDTPSQMQVTdvqdNSISIRWLPSSSpVTGYRVTAvp 1673
Cdd:COG4733   505 ---TITAVQhaPEKYAAIDAGAFDDVPPQWP---PVNVTTSESLSVVAQGTAV----TTLTVSWDAPAG-AVAYEVEW-- 571

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1674 KKGHGptkTKNVPPDQTQVTIEGLQPTV-EYMVSVYAQNQNGESLPLVETAVTNID-------RPKGLTfTEVDVDSIKI 1745
Cdd:COG4733   572 RRDDG---NWVSVPRTSGTSFEVPGIYAgDYEVRVRAINALGVSSAWAASSETTVTgktapppAPTGLT-ATGGLGGITL 647

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1746 AWESPQG-QVTRYRVTYSSPEDGIHELLPAPGGEEDTAELHGLRPGSEYTINIVAIYD--DMESLPLTGTQSTAIPPPTN 1822
Cdd:COG4733   648 SWSFPVDaDTLRTEIRYSTTGDWASATVAQALYPGNTYTLAGLKAGQTYYYRARAVDRsgNVSAWWVSGQASADAAGILD 727

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1823 LKFTQVTPTSLTVN--WNAPNVRLTGYRVRVNPKEKTGPMKEINLSPDSTSAVVSGLMVATKYEVSVYAlKDSLTSRPAQ 1900
Cdd:COG4733   728 AITGQILETELGQEldAIIQNATVAEVVAATVTDVTAQIDTAVLFAGVATAAAIGAEARVAATVAESAT-AAAATGTAAD 806

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971404011 1901 GVVTTLENVSPPRRARVTDATETTITITWRTKTETITGFQIDAIPAASGQNPIQRTISPDVRTYTITGLQPGN---DYKI 1977
Cdd:COG4733   807 AAGDASGGVTAGTSGTTGAGDTAASTTRVAAAVVLAGVVVYGDAIIESGNTGDIVATGDIASAAAGAVATTVSgttAADV 886

                         490       500
                  ....*....|....*....|....
gi 971404011 1978 YLYTLNENARSSPVVIDASTAIDA 2001
Cdd:COG4733   887 SAVADSTAASLTAIVIAATTIIDA 910
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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