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Conserved domains on  [gi|1387209611|ref|XP_015330292|]
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DEP domain-containing protein 7 isoform X1 [Bos taurus]

Protein Classification

DEP and RhoGAP_BRCC3-like domain-containing protein( domain architecture ID 10241509)

DEP and RhoGAP_BRCC3-like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 115-348 1.13e-107

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239870  Cd Length: 235  Bit Score: 317.73  E-value: 1.13e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387209611 115 LSPQVINEVWQEETIGRLLQLIDLPLLDSLLKRQEMIPKVSQPKRQLDLVNNrNYLDRGILKAYSDSQEDEWLSSAIDCL 194
Cdd:cd04405     1 LSPEVVEEIWKEQTLIRLLQLVGLPLLEELLDPALVNPKHISYNMDPDVYTS-NYLDREVVKLFSKSQLDHWLLSAMDCL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387209611 195 EYLPDQMVVDISRNFPEQPDRIDLVKELLFDAISKYYSS-REPLL-NHLSDVHNGIAELLVNGKTEIALEATQLFLKLLD 272
Cdd:cd04405    80 ANWPDQLVVDVSRPLYSQHDMLSGFKRLLFKTIAKYYGQlKEPLLtFHLFDIFVGILELLGNGKEEVALEALQLCLLLLP 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1387209611 273 SQNREEFRRLLYFMAVAAHPSEFKLQQESDNRMVVKRMFSKAIVHNKNLSKGKTDLLVLFLMDHQRDVFKIPGTLH 348
Cdd:cd04405   160 PASRRELRRLLRFMARAAKNDMPRLHKEIENRMLVKQTFSRAILCSKDLDEGLADLLVLFLMDHHQDIFKVPGSLH 235
DEP super family cl02442
DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first ...
 1-54 1.43e-27

DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is present. New studies show that the DEP domain of Sst2, a yeast RGS protein is necessary and sufficient for receptor interaction.


The actual alignment was detected with superfamily member cd04446:

Pssm-ID: 470580  Cd Length: 95  Bit Score: 105.14  E-value: 1.43e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1387209611   1 MQNKYFGDVDIPRAKVVRVCQALMDYKVFEAVPTKVFGKDKKPTFEDSSCSLYR 54
Cdd:cd04446    42 MQNKYFGDVDVPRAKAVRLCQALMDCRVFEAVGTKVFKKKKRAVFEDSSSSLYR 95
 
Name Accession Description Interval E-value
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 115-348 1.13e-107

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239870  Cd Length: 235  Bit Score: 317.73  E-value: 1.13e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387209611 115 LSPQVINEVWQEETIGRLLQLIDLPLLDSLLKRQEMIPKVSQPKRQLDLVNNrNYLDRGILKAYSDSQEDEWLSSAIDCL 194
Cdd:cd04405     1 LSPEVVEEIWKEQTLIRLLQLVGLPLLEELLDPALVNPKHISYNMDPDVYTS-NYLDREVVKLFSKSQLDHWLLSAMDCL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387209611 195 EYLPDQMVVDISRNFPEQPDRIDLVKELLFDAISKYYSS-REPLL-NHLSDVHNGIAELLVNGKTEIALEATQLFLKLLD 272
Cdd:cd04405    80 ANWPDQLVVDVSRPLYSQHDMLSGFKRLLFKTIAKYYGQlKEPLLtFHLFDIFVGILELLGNGKEEVALEALQLCLLLLP 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1387209611 273 SQNREEFRRLLYFMAVAAHPSEFKLQQESDNRMVVKRMFSKAIVHNKNLSKGKTDLLVLFLMDHQRDVFKIPGTLH 348
Cdd:cd04405   160 PASRRELRRLLRFMARAAKNDMPRLHKEIENRMLVKQTFSRAILCSKDLDEGLADLLVLFLMDHHQDIFKVPGSLH 235
DEP_DEPDC4 cd04446
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a ...
 1-54 1.43e-27

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a DEP domain containing protein of unknown function.


Pssm-ID: 239893  Cd Length: 95  Bit Score: 105.14  E-value: 1.43e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1387209611   1 MQNKYFGDVDIPRAKVVRVCQALMDYKVFEAVPTKVFGKDKKPTFEDSSCSLYR 54
Cdd:cd04446    42 MQNKYFGDVDVPRAKAVRLCQALMDCRVFEAVGTKVFKKKKRAVFEDSSSSLYR 95
DEP smart00049
Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in ...
 11-57 6.13e-04

Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in signalling proteins that contain PH, rasGEF, rhoGEF, rhoGAP, RGS, PDZ domains. DEP domain in Drosophila dishevelled is essential to rescue planar polarity defects and induce JNK signalling (Cell 94, 109-118).


Pssm-ID: 214489  Cd Length: 77  Bit Score: 38.42  E-value: 6.13e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1387209611   11 IPRAKVVRVCQALMDYKVFEAVPTkvfgkDKKPTFEDSSCsLYRFTT 57
Cdd:smart00049  37 IDREEAVHLGQLLLDEGLIHHVNG-----PNKHTFKDSKA-LYRFTT 77
 
Name Accession Description Interval E-value
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 115-348 1.13e-107

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239870  Cd Length: 235  Bit Score: 317.73  E-value: 1.13e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387209611 115 LSPQVINEVWQEETIGRLLQLIDLPLLDSLLKRQEMIPKVSQPKRQLDLVNNrNYLDRGILKAYSDSQEDEWLSSAIDCL 194
Cdd:cd04405     1 LSPEVVEEIWKEQTLIRLLQLVGLPLLEELLDPALVNPKHISYNMDPDVYTS-NYLDREVVKLFSKSQLDHWLLSAMDCL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387209611 195 EYLPDQMVVDISRNFPEQPDRIDLVKELLFDAISKYYSS-REPLL-NHLSDVHNGIAELLVNGKTEIALEATQLFLKLLD 272
Cdd:cd04405    80 ANWPDQLVVDVSRPLYSQHDMLSGFKRLLFKTIAKYYGQlKEPLLtFHLFDIFVGILELLGNGKEEVALEALQLCLLLLP 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1387209611 273 SQNREEFRRLLYFMAVAAHPSEFKLQQESDNRMVVKRMFSKAIVHNKNLSKGKTDLLVLFLMDHQRDVFKIPGTLH 348
Cdd:cd04405   160 PASRRELRRLLRFMARAAKNDMPRLHKEIENRMLVKQTFSRAILCSKDLDEGLADLLVLFLMDHHQDIFKVPGSLH 235
DEP_DEPDC4 cd04446
DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a ...
 1-54 1.43e-27

DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in DEPDC4-like proteins. DEPDC4 is a DEP domain containing protein of unknown function.


Pssm-ID: 239893  Cd Length: 95  Bit Score: 105.14  E-value: 1.43e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1387209611   1 MQNKYFGDVDIPRAKVVRVCQALMDYKVFEAVPTKVFGKDKKPTFEDSSCSLYR 54
Cdd:cd04446    42 MQNKYFGDVDVPRAKAVRLCQALMDCRVFEAVGTKVFKKKKRAVFEDSSSSLYR 95
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 235-347 4.86e-04

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 41.29  E-value: 4.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387209611 235 EPLLNHLS-DVHNGIAELLVN---GKTEIA------LEATQLFLKLLDSQNREEFR---RLLYFMAvaahpsefklQQES 301
Cdd:cd04392    77 EPLLTHAHyPAHLQIADLCQFdekGNKTSApdkerlLEALQLLLLLLPEENRNLLKlilDLLYQTA----------KHED 146

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1387209611 302 DNRMV---VKRMFSKAIVHNKNLSKG-------KTDLLVLFLMDHQRDVFKIPGTL 347
Cdd:cd04392   147 KNKMSadnLALLFTPHLICPRNLTPEdlhenaqKLNSIVTFMIKHSQKLFKAPAYL 202
DEP smart00049
Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in ...
 11-57 6.13e-04

Domain found in Dishevelled, Egl-10, and Pleckstrin; Domain of unknown function present in signalling proteins that contain PH, rasGEF, rhoGEF, rhoGAP, RGS, PDZ domains. DEP domain in Drosophila dishevelled is essential to rescue planar polarity defects and induce JNK signalling (Cell 94, 109-118).


Pssm-ID: 214489  Cd Length: 77  Bit Score: 38.42  E-value: 6.13e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1387209611   11 IPRAKVVRVCQALMDYKVFEAVPTkvfgkDKKPTFEDSSCsLYRFTT 57
Cdd:smart00049  37 IDREEAVHLGQLLLDEGLIHHVNG-----PNKHTFKDSKA-LYRFTT 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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