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Conserved domains on  [gi|1034560279|ref|XP_016857322|]
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prospero homeobox protein 1 isoform X2 [Homo sapiens]

Protein Classification

homeo-prospero domain-containing protein( domain architecture ID 19868209)

homeo-prospero domain (HPD)-containing protein similar to Drosophila melanogaster homeobox protein prospero, a homeodomain protein that controls neuronal identity

CATH:  1.10.10.500
Gene Ontology:  GO:0003677|GO:0003700
PubMed:  12429095|15837198

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
HPD pfam05044
Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is ...
579-732 9.73e-113

Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos. It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. homologs of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain. However, the structure shows that these two regions form a single stable structural domain as defined here. This homeo-prospero domain binds to DNA.


:

Pssm-ID: 461534  Cd Length: 154  Bit Score: 337.48  E-value: 9.73e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034560279 579 GLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRD 658
Cdd:pfam05044   1 GLTPMHLKKAKLMFFYTRYPSSNVLKTYFPDVKFNRCNTSQLIKWFSNFREFYYIQMEKFARQALSEGVTDAEDLLVSRD 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034560279 659 CELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQ 732
Cdd:pfam05044  81 SELFRVLNLHYNKNNDFEVPDRFLEVVQLTLREFFNAIQAGKDSDPSWKKAIYKVICKLDSEVPEIFKSPNFLE 154
HEC1 super family cl34933
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
136-444 8.69e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG5185:

Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 42.64  E-value: 8.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034560279 136 SPPECLSPFGRPTMSQFDMDRLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQ 215
Cdd:COG5185   230 NIEEALKGFQDPESELEDLAQTSDKLEKLVEQNTDLRLEKLGENAESSKRLNENANNLIKQFENTKEKIAEYTKSIDIKK 309
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034560279 216 QQQQSFQQLVSARKEQKREER------------RQLKQQLEDMQKQLRQLQEKFYQIYDSTD----SENDEDGNLSEDSM 279
Cdd:COG5185   310 ATESLEEQLAAAEAEQELEESkretetgiqnltAEIEQGQESLTENLEAIKEEIENIVGEVElsksSEELDSFKDTIEST 389
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034560279 280 RSEILDARA-------------QDSVGRSDNEMCELDpGQfIDRARALIREQEMAENKPKREGNNKERDHGPNS---LQP 343
Cdd:COG5185   390 KESLDEIPQnqrgyaqeilatlEDTLKAADRQIEELQ-RQ-IEQATSSNEEVSKLLNELISELNKVMREADEESqsrLEE 467
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034560279 344 EGKHLAETLKQELNTAMSQVVDTVVKVFSAKPSRQVPQVFPPLQIPQARFAVNGENHNFHTANQRLQCFGDVIIPN--PL 421
Cdd:COG5185   468 AYDEINRSVRSKKEDLNEELTQIESRVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLKDFMRARGYAHILALENliPA 547
                         330       340
                  ....*....|....*....|...
gi 1034560279 422 DTFGNVQMASSTDQTEALPLVVR 444
Cdd:COG5185   548 SELIQASNAKTDGQAANLRTAVI 570
 
Name Accession Description Interval E-value
HPD pfam05044
Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is ...
579-732 9.73e-113

Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos. It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. homologs of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain. However, the structure shows that these two regions form a single stable structural domain as defined here. This homeo-prospero domain binds to DNA.


Pssm-ID: 461534  Cd Length: 154  Bit Score: 337.48  E-value: 9.73e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034560279 579 GLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRD 658
Cdd:pfam05044   1 GLTPMHLKKAKLMFFYTRYPSSNVLKTYFPDVKFNRCNTSQLIKWFSNFREFYYIQMEKFARQALSEGVTDAEDLLVSRD 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034560279 659 CELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQ 732
Cdd:pfam05044  81 SELFRVLNLHYNKNNDFEVPDRFLEVVQLTLREFFNAIQAGKDSDPSWKKAIYKVICKLDSEVPEIFKSPNFLE 154
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
136-444 8.69e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 42.64  E-value: 8.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034560279 136 SPPECLSPFGRPTMSQFDMDRLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQ 215
Cdd:COG5185   230 NIEEALKGFQDPESELEDLAQTSDKLEKLVEQNTDLRLEKLGENAESSKRLNENANNLIKQFENTKEKIAEYTKSIDIKK 309
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034560279 216 QQQQSFQQLVSARKEQKREER------------RQLKQQLEDMQKQLRQLQEKFYQIYDSTD----SENDEDGNLSEDSM 279
Cdd:COG5185   310 ATESLEEQLAAAEAEQELEESkretetgiqnltAEIEQGQESLTENLEAIKEEIENIVGEVElsksSEELDSFKDTIEST 389
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034560279 280 RSEILDARA-------------QDSVGRSDNEMCELDpGQfIDRARALIREQEMAENKPKREGNNKERDHGPNS---LQP 343
Cdd:COG5185   390 KESLDEIPQnqrgyaqeilatlEDTLKAADRQIEELQ-RQ-IEQATSSNEEVSKLLNELISELNKVMREADEESqsrLEE 467
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034560279 344 EGKHLAETLKQELNTAMSQVVDTVVKVFSAKPSRQVPQVFPPLQIPQARFAVNGENHNFHTANQRLQCFGDVIIPN--PL 421
Cdd:COG5185   468 AYDEINRSVRSKKEDLNEELTQIESRVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLKDFMRARGYAHILALENliPA 547
                         330       340
                  ....*....|....*....|...
gi 1034560279 422 DTFGNVQMASSTDQTEALPLVVR 444
Cdd:COG5185   548 SELIQASNAKTDGQAANLRTAVI 570
 
Name Accession Description Interval E-value
HPD pfam05044
Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is ...
579-732 9.73e-113

Homeo-prospero domain; Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos. It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. homologs of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain. However, the structure shows that these two regions form a single stable structural domain as defined here. This homeo-prospero domain binds to DNA.


Pssm-ID: 461534  Cd Length: 154  Bit Score: 337.48  E-value: 9.73e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034560279 579 GLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRD 658
Cdd:pfam05044   1 GLTPMHLKKAKLMFFYTRYPSSNVLKTYFPDVKFNRCNTSQLIKWFSNFREFYYIQMEKFARQALSEGVTDAEDLLVSRD 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034560279 659 CELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQ 732
Cdd:pfam05044  81 SELFRVLNLHYNKNNDFEVPDRFLEVVQLTLREFFNAIQAGKDSDPSWKKAIYKVICKLDSEVPEIFKSPNFLE 154
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
136-444 8.69e-04

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 42.64  E-value: 8.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034560279 136 SPPECLSPFGRPTMSQFDMDRLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQ 215
Cdd:COG5185   230 NIEEALKGFQDPESELEDLAQTSDKLEKLVEQNTDLRLEKLGENAESSKRLNENANNLIKQFENTKEKIAEYTKSIDIKK 309
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034560279 216 QQQQSFQQLVSARKEQKREER------------RQLKQQLEDMQKQLRQLQEKFYQIYDSTD----SENDEDGNLSEDSM 279
Cdd:COG5185   310 ATESLEEQLAAAEAEQELEESkretetgiqnltAEIEQGQESLTENLEAIKEEIENIVGEVElsksSEELDSFKDTIEST 389
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034560279 280 RSEILDARA-------------QDSVGRSDNEMCELDpGQfIDRARALIREQEMAENKPKREGNNKERDHGPNS---LQP 343
Cdd:COG5185   390 KESLDEIPQnqrgyaqeilatlEDTLKAADRQIEELQ-RQ-IEQATSSNEEVSKLLNELISELNKVMREADEESqsrLEE 467
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034560279 344 EGKHLAETLKQELNTAMSQVVDTVVKVFSAKPSRQVPQVFPPLQIPQARFAVNGENHNFHTANQRLQCFGDVIIPN--PL 421
Cdd:COG5185   468 AYDEINRSVRSKKEDLNEELTQIESRVSTLKATLEKLRAKLERQLEGVRSKLDQVAESLKDFMRARGYAHILALENliPA 547
                         330       340
                  ....*....|....*....|...
gi 1034560279 422 DTFGNVQMASSTDQTEALPLVVR 444
Cdd:COG5185   548 SELIQASNAKTDGQAANLRTAVI 570
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
225-289 6.93e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 39.61  E-value: 6.93e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034560279 225 VSARKEQKREERRQLKQQLEDMQKQLRQLQEK---FYQIYDSTDSENDEDGNLSE-DSMRSEILDARAQ 289
Cdd:COG3206   166 LELRREEARKALEFLEEQLPELRKELEEAEAAleeFRQKNGLVDLSEEAKLLLQQlSELESQLAEARAE 234
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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