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Conserved domains on  [gi|1034660937|ref|XP_016869134|]
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gasdermin-C isoform X6 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Gasdermin_C pfam17708
Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion ...
164-333 8.36e-76

Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


:

Pssm-ID: 407590  Cd Length: 174  Bit Score: 231.48  E-value: 8.36e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660937 164 WQNFKHLQEEVFQKIKTLAQLSKDVQDVMFYSILAMLRDRGALQDLMNMLEL----DSSGHLDGPGGAILKKLQQDSNHA 239
Cdd:pfam17708   1 HGDFSVLKKEVERQFQPLAKLPKDLQRALFSSLLALLRDEEALQALEDMLEDlcggGELGPLDGPDGAILLELVGDSGLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660937 240 WFNPKDPILYLLEAIMVLSDFQHDLLACSMEKRILLQQQELVRSILEPNFRYPWSIPFTLKPELLAPLQSEGLAITYGLL 319
Cdd:pfam17708  81 SQELADAILYLLSALAELSDTQLVLLATCCELQILPAQLELVESILEQNFLYQENIPFSLPPPLLAPLQDEELAITQRLL 160
                         170
                  ....*....|....
gi 1034660937 320 EECGLRMELDNPRS 333
Cdd:pfam17708 161 ESCGLELELDSPKA 174
Gasdermin super family cl20270
Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion ...
20-91 8.87e-13

Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


The actual alignment was detected with superfamily member pfam04598:

Pssm-ID: 398339  Cd Length: 240  Bit Score: 67.00  E-value: 8.87e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660937  20 KKETVGSRAIISEG-----VPEERGqpGQGQGESLRVKKKALTLQKGMVMAYKRKQLVIKEKA---ILISDDDEQRTFQD 91
Cdd:pfam04598 163 TQEVVLTEHSQVEGsgkgmLPGTKT--VQGSGQGHKDKKVAVTIPKGTVLAYRVIQLVIKSDGqweILLLDDDKQGTFEP 240
 
Name Accession Description Interval E-value
Gasdermin_C pfam17708
Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion ...
164-333 8.36e-76

Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


Pssm-ID: 407590  Cd Length: 174  Bit Score: 231.48  E-value: 8.36e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660937 164 WQNFKHLQEEVFQKIKTLAQLSKDVQDVMFYSILAMLRDRGALQDLMNMLEL----DSSGHLDGPGGAILKKLQQDSNHA 239
Cdd:pfam17708   1 HGDFSVLKKEVERQFQPLAKLPKDLQRALFSSLLALLRDEEALQALEDMLEDlcggGELGPLDGPDGAILLELVGDSGLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660937 240 WFNPKDPILYLLEAIMVLSDFQHDLLACSMEKRILLQQQELVRSILEPNFRYPWSIPFTLKPELLAPLQSEGLAITYGLL 319
Cdd:pfam17708  81 SQELADAILYLLSALAELSDTQLVLLATCCELQILPAQLELVESILEQNFLYQENIPFSLPPPLLAPLQDEELAITQRLL 160
                         170
                  ....*....|....
gi 1034660937 320 EECGLRMELDNPRS 333
Cdd:pfam17708 161 ESCGLELELDSPKA 174
Gasdermin pfam04598
Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion ...
20-91 8.87e-13

Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


Pssm-ID: 398339  Cd Length: 240  Bit Score: 67.00  E-value: 8.87e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660937  20 KKETVGSRAIISEG-----VPEERGqpGQGQGESLRVKKKALTLQKGMVMAYKRKQLVIKEKA---ILISDDDEQRTFQD 91
Cdd:pfam04598 163 TQEVVLTEHSQVEGsgkgmLPGTKT--VQGSGQGHKDKKVAVTIPKGTVLAYRVIQLVIKSDGqweILLLDDDKQGTFEP 240
 
Name Accession Description Interval E-value
Gasdermin_C pfam17708
Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion ...
164-333 8.36e-76

Gasdermin PUB domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


Pssm-ID: 407590  Cd Length: 174  Bit Score: 231.48  E-value: 8.36e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660937 164 WQNFKHLQEEVFQKIKTLAQLSKDVQDVMFYSILAMLRDRGALQDLMNMLEL----DSSGHLDGPGGAILKKLQQDSNHA 239
Cdd:pfam17708   1 HGDFSVLKKEVERQFQPLAKLPKDLQRALFSSLLALLRDEEALQALEDMLEDlcggGELGPLDGPDGAILLELVGDSGLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660937 240 WFNPKDPILYLLEAIMVLSDFQHDLLACSMEKRILLQQQELVRSILEPNFRYPWSIPFTLKPELLAPLQSEGLAITYGLL 319
Cdd:pfam17708  81 SQELADAILYLLSALAELSDTQLVLLATCCELQILPAQLELVESILEQNFLYQENIPFSLPPPLLAPLQDEELAITQRLL 160
                         170
                  ....*....|....
gi 1034660937 320 EECGLRMELDNPRS 333
Cdd:pfam17708 161 ESCGLELELDSPKA 174
Gasdermin pfam04598
Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion ...
20-91 8.87e-13

Gasdermin pore forming domain; The precise function of this protein is unknown. A deletion/insertion mutation is associated with an autosomal dominant non-syndromic hearing impairment form. In addition, this protein has also been found to contribute to acquired etoposide resistance in melanoma cells. This family also includes the gasdermin protein


Pssm-ID: 398339  Cd Length: 240  Bit Score: 67.00  E-value: 8.87e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660937  20 KKETVGSRAIISEG-----VPEERGqpGQGQGESLRVKKKALTLQKGMVMAYKRKQLVIKEKA---ILISDDDEQRTFQD 91
Cdd:pfam04598 163 TQEVVLTEHSQVEGsgkgmLPGTKT--VQGSGQGHKDKKVAVTIPKGTVLAYRVIQLVIKSDGqweILLLDDDKQGTFEP 240
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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