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Conserved domains on  [gi|1034661683|ref|XP_016869372|]
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solute carrier organic anion transporter family member 5A1 isoform X2 [Homo sapiens]

Protein Classification

solute carrier organic anion transporter( domain architecture ID 13024461)

solute carrier organic anion transporter is a major facilitator superfamily (MFS) transporter that mediates the Na(+)-independent high affinity transport of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, and the thyroid hormones thyroxine and triiodothyronine, among others

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
128-674 0e+00

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 665.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 128 RCFLVCMCFLTFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGGLLIAF 207
Cdd:cd17404     1 KAFLVCMCLLIFIQSALSSGYLNSVITTIEKRYSLKSSESGLIVSSYEIGSLLTVVFVSYFGGRGHRPRWIAVGGVLIAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 208 GAALFALPHFisppyqiqelnasapndglcqggnstatleppacpkdsggnnhwvyvalFICAQILIGMGSTPIYTLGPT 287
Cdd:cd17404    81 GSFLFSLPHF-------------------------------------------------FILAQILIGMGGTPIFTLGTT 111
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 288 YLDDNVKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFYVDPRN-PVHLDQNDPRFIGNWWSGFLLCAIAMFLVIFPMF 366
Cdd:cd17404   112 YLDDHVKKESSSLYLAIMYVMGALGPAAGFLLGGLLINFYVDPLStPPDISPGDPRWIGAWWGGFLLCGIALLLVAFPFF 191
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 367 TFpkklpprhkkkkkkkfsvdavsdddvlkeksnnseqadkkvssmgfgkdvrdlPRaavrilsnMTFLFVSLSYTAESA 446
Cdd:cd17404   192 TF-----------------------------------------------------PK--------MTFLVVSLGYCMELA 210
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 447 IVTAFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFSTLFIVGC 526
Cdd:cd17404   211 IVSGFITFLPKYLETQFGIPASNANIFTGVIAVPGAGIGIVLGGYILKRFKLGPKGAAKLALICNFLSLLLFLTLFFLGC 290
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 527 ESINLGGINIPYTTGPSLTMPH-RNLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCVNSGNLSTGIRNYTECTCVQ 605
Cdd:cd17404   291 ESIKLAGITIPYTTGPSLSSTHgRNLTSECNVNCGCSINEYEPVCGSDGITYFSPCLAGCTSVGNTSTGIRNYTNCACLQ 370
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034661683 606 SRQVITPPTVGQRSQLRVvivktylnengyavsGKCKRTCNTLIPFLVFLFIVTFITACAQPSAIIVTL 674
Cdd:cd17404   371 SRSSISPPTVGQGSQLQA---------------GPCSRTCNTLIPFLILLFIVTLITACAQMPALMITL 424
 
Name Accession Description Interval E-value
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
128-674 0e+00

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 665.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 128 RCFLVCMCFLTFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGGLLIAF 207
Cdd:cd17404     1 KAFLVCMCLLIFIQSALSSGYLNSVITTIEKRYSLKSSESGLIVSSYEIGSLLTVVFVSYFGGRGHRPRWIAVGGVLIAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 208 GAALFALPHFisppyqiqelnasapndglcqggnstatleppacpkdsggnnhwvyvalFICAQILIGMGSTPIYTLGPT 287
Cdd:cd17404    81 GSFLFSLPHF-------------------------------------------------FILAQILIGMGGTPIFTLGTT 111
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 288 YLDDNVKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFYVDPRN-PVHLDQNDPRFIGNWWSGFLLCAIAMFLVIFPMF 366
Cdd:cd17404   112 YLDDHVKKESSSLYLAIMYVMGALGPAAGFLLGGLLINFYVDPLStPPDISPGDPRWIGAWWGGFLLCGIALLLVAFPFF 191
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 367 TFpkklpprhkkkkkkkfsvdavsdddvlkeksnnseqadkkvssmgfgkdvrdlPRaavrilsnMTFLFVSLSYTAESA 446
Cdd:cd17404   192 TF-----------------------------------------------------PK--------MTFLVVSLGYCMELA 210
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 447 IVTAFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFSTLFIVGC 526
Cdd:cd17404   211 IVSGFITFLPKYLETQFGIPASNANIFTGVIAVPGAGIGIVLGGYILKRFKLGPKGAAKLALICNFLSLLLFLTLFFLGC 290
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 527 ESINLGGINIPYTTGPSLTMPH-RNLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCVNSGNLSTGIRNYTECTCVQ 605
Cdd:cd17404   291 ESIKLAGITIPYTTGPSLSSTHgRNLTSECNVNCGCSINEYEPVCGSDGITYFSPCLAGCTSVGNTSTGIRNYTNCACLQ 370
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034661683 606 SRQVITPPTVGQRSQLRVvivktylnengyavsGKCKRTCNTLIPFLVFLFIVTFITACAQPSAIIVTL 674
Cdd:cd17404   371 SRSSISPPTVGQGSQLQA---------------GPCSRTCNTLIPFLILLFIVTLITACAQMPALMITL 424
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
129-674 1.20e-161

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 427161 [Multi-domain]  Cd Length: 526  Bit Score: 475.54  E-value: 1.20e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 129 CFLVCMCFLTFIQAlMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGGLLIAFG 208
Cdd:pfam03137   1 GFLVFLSLLGLAQA-LVSGYFNSSITTIEKRFGLPSSLSGLISSSYDIGNLLLILFVSYFGGKGHRPRWIGVGSLLMGLG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 209 AALFALPHFISppyqiqelnasapndglcqggnstatleppacpkdsggnnhwvyvalFICAQILIGMGSTPIYTLGPTY 288
Cdd:pfam03137  80 SLLFALPHFLS-----------------------------------------------FFLGQLLLGIGGTPLYTLGISY 112
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 289 LDDNVKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFYVDP-RNPVHLDQNDPRFIGNWWSGFLLCAIAMFLVIFPMFT 367
Cdd:pfam03137 113 IDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIgSVSLTLTPKDPRWVGAWWLGFLIAGLLLLLTAIPFFF 192
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 368 FPKKLPPRhkkkkkkkfsvdAVSDDDVLKEKSNNSEQADKKVSSMGFGKDVRDLPRAAVRILSNMTFLFVSLSYTAESAI 447
Cdd:pfam03137 193 FPKSLPGT------------AKRRAEKKKEPESHSIKDSEKTKSLKLGKSLKDFPRALKRLLKNPVYMLLTLASVSEFLL 260
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 448 VTAFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFSTLFIVGCE 527
Cdd:pfam03137 261 IAGYATFLPKYIETQFGLSASTANLLTGVVLIPGAALGILLGGLIIKKFKLSAKGLAKFNLITSLVSLLLSLLLFFLGCP 340
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 528 SINLGGINIPYTTGPSLTmphRNLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCVNSGNLSTGIRNYTECTCvqsr 607
Cdd:pfam03137 341 NSPVAGITVPYGGTQQLS---GNLTASCNSNCSCSTSFYSPVCGSDGIGYTSPCPCGAGCSSSSGAGKSTYNCSCC---- 413
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034661683 608 qvitpptvgqrsqlrVVIVKTYLNENGYAVSGKCKRTC-NTLIPFLVFLFIVTFITACAQPSAIIVTL 674
Cdd:pfam03137 414 ---------------CSCGSSTSGGNGSATPGKCPSDCsNKLPLFLALLFLASFFSSLSSTPGTLIIL 466
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
118-674 4.55e-113

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 354.04  E-value: 4.55e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 118 RCLYVVLTDSRCFLVCmCFLTFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLW 197
Cdd:TIGR00805  22 RCLQSLFSKIKMFSLL-LTCARLQGLLVNGLVNSMLTSIERRFKIPTSRSGFINGSYEIGNLLLIIFVSYFGTKLHRPIV 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 198 LAVGGLLIAFGAALFALPHFISPPYQ-----IQELNASAPNDGLCQGgNSTATLEPPACPKDSGGNNHWVYVALFICAQI 272
Cdd:TIGR00805 101 IGAGCAIMGLGSLLSSLPHFLMGRYSysttvSSTGNLSSANSFLCME-NLTQTLRPTQDPSECQKQHKSLMWLLFLVSNI 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 273 LIGMGSTPIYTLGPTYLDDNVKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFYVD----PRNPVHLDQNDPRFIGNWW 348
Cdd:TIGR00805 180 LRGIGATPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDtgsvNTEDLIITPTDPRWIGAWW 259
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 349 SGFLLCAIAMFLVIFPMFTFPKKLPPRHKkkkkkkfsvdAVSDDDVLKEKSNNSEQADKKVSSMgfgkDVRDLPRAAVRI 428
Cdd:TIGR00805 260 IGFLVCGFVALLTSIPLFFFPKTLPKEGK----------RVNVDVHEAEKLEKSRGEDRKKNSG----ITKDFPKFIKRL 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 429 LSNMTFLFVSLSYTAESAIVTAFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAM 508
Cdd:TIGR00805 326 LCNKIYMLVILAQVIDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAYFAI 405
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 509 ICSGVSLLCFSTLFIVGCESINLGGINIPYTTGPSltmpHRNLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCVNS 588
Cdd:TIGR00805 406 CLSTLEYLLYSPKFLITCESAPVAGVNNPSNDQPL----YVENRTDCNRQCSCDSSIWDPVCGDNGLAYLSPCHAGCRMS 481
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 589 GNLSTGIrNYTECTCVQSrqvitpptvgqrsqlrvvivktylNENGYAVSGKCKRTC-NTLIPFLVFLFIVTFITACAQP 667
Cdd:TIGR00805 482 VGTGSNM-VFTNCSCIQT------------------------PGNSSAKKGLCDPPCaTSLQYFLILFIPLSFIYFITAV 536

                  ....*..
gi 1034661683 668 SAIIVTL 674
Cdd:TIGR00805 537 PGYMVLL 543
KAZAL smart00280
Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...
565-592 2.22e-04

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.


Pssm-ID: 197624  Cd Length: 46  Bit Score: 39.20  E-value: 2.22e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1034661683  565 EYEPVCGSDGITYFNPC---LAGCVNSGNLS 592
Cdd:smart00280   9 EYDPVCGSDGVTYSNEChlcKAACESGKSIE 39
 
Name Accession Description Interval E-value
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
128-674 0e+00

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 665.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 128 RCFLVCMCFLTFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGGLLIAF 207
Cdd:cd17404     1 KAFLVCMCLLIFIQSALSSGYLNSVITTIEKRYSLKSSESGLIVSSYEIGSLLTVVFVSYFGGRGHRPRWIAVGGVLIAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 208 GAALFALPHFisppyqiqelnasapndglcqggnstatleppacpkdsggnnhwvyvalFICAQILIGMGSTPIYTLGPT 287
Cdd:cd17404    81 GSFLFSLPHF-------------------------------------------------FILAQILIGMGGTPIFTLGTT 111
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 288 YLDDNVKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFYVDPRN-PVHLDQNDPRFIGNWWSGFLLCAIAMFLVIFPMF 366
Cdd:cd17404   112 YLDDHVKKESSSLYLAIMYVMGALGPAAGFLLGGLLINFYVDPLStPPDISPGDPRWIGAWWGGFLLCGIALLLVAFPFF 191
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 367 TFpkklpprhkkkkkkkfsvdavsdddvlkeksnnseqadkkvssmgfgkdvrdlPRaavrilsnMTFLFVSLSYTAESA 446
Cdd:cd17404   192 TF-----------------------------------------------------PK--------MTFLVVSLGYCMELA 210
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 447 IVTAFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFSTLFIVGC 526
Cdd:cd17404   211 IVSGFITFLPKYLETQFGIPASNANIFTGVIAVPGAGIGIVLGGYILKRFKLGPKGAAKLALICNFLSLLLFLTLFFLGC 290
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 527 ESINLGGINIPYTTGPSLTMPH-RNLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCVNSGNLSTGIRNYTECTCVQ 605
Cdd:cd17404   291 ESIKLAGITIPYTTGPSLSSTHgRNLTSECNVNCGCSINEYEPVCGSDGITYFSPCLAGCTSVGNTSTGIRNYTNCACLQ 370
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034661683 606 SRQVITPPTVGQRSQLRVvivktylnengyavsGKCKRTCNTLIPFLVFLFIVTFITACAQPSAIIVTL 674
Cdd:cd17404   371 SRSSISPPTVGQGSQLQA---------------GPCSRTCNTLIPFLILLFIVTLITACAQMPALMITL 424
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
129-674 1.20e-161

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 427161 [Multi-domain]  Cd Length: 526  Bit Score: 475.54  E-value: 1.20e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 129 CFLVCMCFLTFIQAlMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGGLLIAFG 208
Cdd:pfam03137   1 GFLVFLSLLGLAQA-LVSGYFNSSITTIEKRFGLPSSLSGLISSSYDIGNLLLILFVSYFGGKGHRPRWIGVGSLLMGLG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 209 AALFALPHFISppyqiqelnasapndglcqggnstatleppacpkdsggnnhwvyvalFICAQILIGMGSTPIYTLGPTY 288
Cdd:pfam03137  80 SLLFALPHFLS-----------------------------------------------FFLGQLLLGIGGTPLYTLGISY 112
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 289 LDDNVKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFYVDP-RNPVHLDQNDPRFIGNWWSGFLLCAIAMFLVIFPMFT 367
Cdd:pfam03137 113 IDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIgSVSLTLTPKDPRWVGAWWLGFLIAGLLLLLTAIPFFF 192
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 368 FPKKLPPRhkkkkkkkfsvdAVSDDDVLKEKSNNSEQADKKVSSMGFGKDVRDLPRAAVRILSNMTFLFVSLSYTAESAI 447
Cdd:pfam03137 193 FPKSLPGT------------AKRRAEKKKEPESHSIKDSEKTKSLKLGKSLKDFPRALKRLLKNPVYMLLTLASVSEFLL 260
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 448 VTAFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFSTLFIVGCE 527
Cdd:pfam03137 261 IAGYATFLPKYIETQFGLSASTANLLTGVVLIPGAALGILLGGLIIKKFKLSAKGLAKFNLITSLVSLLLSLLLFFLGCP 340
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 528 SINLGGINIPYTTGPSLTmphRNLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCVNSGNLSTGIRNYTECTCvqsr 607
Cdd:pfam03137 341 NSPVAGITVPYGGTQQLS---GNLTASCNSNCSCSTSFYSPVCGSDGIGYTSPCPCGAGCSSSSGAGKSTYNCSCC---- 413
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034661683 608 qvitpptvgqrsqlrVVIVKTYLNENGYAVSGKCKRTC-NTLIPFLVFLFIVTFITACAQPSAIIVTL 674
Cdd:pfam03137 414 ---------------CSCGSSTSGGNGSATPGKCPSDCsNKLPLFLALLFLASFFSSLSSTPGTLIIL 466
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
128-674 6.03e-143

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 423.19  E-value: 6.03e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 128 RCFLVCMCFLTFIQAlMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGGLLIAF 207
Cdd:cd17336     2 KVFVVLLCLLGLLQG-AVVSYFVSTITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 208 GAALFALPHFisppyqiqelnasapndglcqggnstatleppacpkdsggnnhwvyvalFICAQILIGMGSTPIYTLGPT 287
Cdd:cd17336    81 GCFLLALPHF-------------------------------------------------LFVGQFLLGIGSSPLYTLGIT 111
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 288 YLDDNVKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFYVDP-RNPVHLDQNDPRFIGNWWSGFLLCAIAMFLVIFPMF 366
Cdd:cd17336   112 YIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGSFLLRIYVDFsRVPLGITPDDPRWIGAWWLGFLILGILLLIVSIPLF 191
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 367 TFpkklpprhkkkkkkkfsvdavsdddvlkeksnnseqadkkvssmgfgkdvrdlPRaavrilsnmTFLFVSLSYTAESA 446
Cdd:cd17336   192 FF-----------------------------------------------------PP---------IFILLLLAIVFESF 209
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 447 IVTAFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFSTLFIVGC 526
Cdd:cd17336   210 AISGFSTFLPKYLETQFRLSASLASLLTGLILVPGAALGILLGGLIIKKFKLTARGLAKFVLILSLLSVILYISLFFLGC 289
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 527 ESINLGGINIPYTTGPSltmphrNLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCVNSgNLSTGIRNYTECTCVQS 606
Cdd:cd17336   290 DNPPIAGVTTPYGSSSS------PITSSCNSDCNCSDSSFSPVCGSDGITYFSPCHAGCTSS-DAGNGTKTYSNCSCINS 362
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034661683 607 RQVITPPTVGQRSQlrvvivktylnengyavsgkCKRTCNTLIPFLVFLFIVTFITACAQPSAIIVTL 674
Cdd:cd17336   363 GTATSSGCPPDCSV--------------------APNCCSKLIPFLAVLFLSSFLLSLSIVPSTMITL 410
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
127-674 4.85e-129

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 387.76  E-value: 4.85e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 127 SRCFLVCMCFLTFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGGLLIA 206
Cdd:cd17403     1 PKGFLFFLCIFAFLQGMVVNGFVNVSITTIEKRFGLTSTQTGLIASSYDIASVLLLLFVSYFGGRGHKPRWLGIGAFIMG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 207 FGAALFALPHFIsppyqiqelnasapndglcqggnstatleppacpkdsggnnhwvyvaLFICAQILIGMGSTPIYTLGP 286
Cdd:cd17403    81 IGSLVFALPHFT-----------------------------------------------VFILAQLLHGAGATPLYTLGV 113
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 287 TYLDDNVKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFYVD---PRNPVHLDQNDPRFIGNWWSGFLLCAIAMFLVIF 363
Cdd:cd17403   114 TYLDENVSTKMSPLYIGIFYAMAILGPAIGYVLGGFLLNLYTDidqVDSELGLTPDDPRWVGAWWLGFLISGALALIIAF 193
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 364 PMFtfpkklpprhkkkkkkkfsvdavsdddvlkeksnnseqadkkvssmGFGKdvrdlpraavrilsnmTFLFVSLSYTA 443
Cdd:cd17403   194 PLL----------------------------------------------GFPP----------------TFMFLNLAGAS 211
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 444 ESAIVTAFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCfSTLFI 523
Cdd:cd17403   212 EGMLLAGFATFLPKLIESQFSLSASLAALLVGVVVVPGGILGTFLGGLIVKKLKLKCKGILKFCIVCSIVAFLF-SFILL 290
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 524 VGCESINLGGINIPYTTGPSLTMPhrNLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCVNSGNLStGIRNYTECTC 603
Cdd:cd17403   291 IYCPNAPFAGVTVPYGNSPLEGTS--NLTSTCNADCHCSEDFYDPVCGSDGVTYYSPCHAGCTTSHGDD-GQKVYSNCSC 367
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034661683 604 VQSRQVITpptvgqrsqlrvvivktylNENGYAVSGKCKRTCNTLIPFLVFLFIVTFITACAQPSAIIVTL 674
Cdd:cd17403   368 IQSNSSKT-------------------STAATGKACPCETCCQKLYLFLAVFFLLIVFTFMSSTPALSATL 419
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
118-674 4.55e-113

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 354.04  E-value: 4.55e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 118 RCLYVVLTDSRCFLVCmCFLTFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLW 197
Cdd:TIGR00805  22 RCLQSLFSKIKMFSLL-LTCARLQGLLVNGLVNSMLTSIERRFKIPTSRSGFINGSYEIGNLLLIIFVSYFGTKLHRPIV 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 198 LAVGGLLIAFGAALFALPHFISPPYQ-----IQELNASAPNDGLCQGgNSTATLEPPACPKDSGGNNHWVYVALFICAQI 272
Cdd:TIGR00805 101 IGAGCAIMGLGSLLSSLPHFLMGRYSysttvSSTGNLSSANSFLCME-NLTQTLRPTQDPSECQKQHKSLMWLLFLVSNI 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 273 LIGMGSTPIYTLGPTYLDDNVKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFYVD----PRNPVHLDQNDPRFIGNWW 348
Cdd:TIGR00805 180 LRGIGATPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDtgsvNTEDLIITPTDPRWIGAWW 259
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 349 SGFLLCAIAMFLVIFPMFTFPKKLPPRHKkkkkkkfsvdAVSDDDVLKEKSNNSEQADKKVSSMgfgkDVRDLPRAAVRI 428
Cdd:TIGR00805 260 IGFLVCGFVALLTSIPLFFFPKTLPKEGK----------RVNVDVHEAEKLEKSRGEDRKKNSG----ITKDFPKFIKRL 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 429 LSNMTFLFVSLSYTAESAIVTAFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAM 508
Cdd:TIGR00805 326 LCNKIYMLVILAQVIDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAYFAI 405
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 509 ICSGVSLLCFSTLFIVGCESINLGGINIPYTTGPSltmpHRNLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCVNS 588
Cdd:TIGR00805 406 CLSTLEYLLYSPKFLITCESAPVAGVNNPSNDQPL----YVENRTDCNRQCSCDSSIWDPVCGDNGLAYLSPCHAGCRMS 481
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 589 GNLSTGIrNYTECTCVQSrqvitpptvgqrsqlrvvivktylNENGYAVSGKCKRTC-NTLIPFLVFLFIVTFITACAQP 667
Cdd:TIGR00805 482 VGTGSNM-VFTNCSCIQT------------------------PGNSSAKKGLCDPPCaTSLQYFLILFIPLSFIYFITAV 536

                  ....*..
gi 1034661683 668 SAIIVTL 674
Cdd:TIGR00805 537 PGYMVLL 543
MFS_SLCO4A_OATP4A cd17462
Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of ...
127-674 1.28e-95

Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4A (SLCO4A), also called Organic anion-transporting polypeptide 4A (OATP4A), subfamily has one mammalian member, OATP4A1 (encoded by SLCO4A1). It is ubiquitously expressed and it mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4A1 is the most abundantly expressed transporter colorectal cancer (CRC) and its role in the transport of estrone sulfate, which is used in hormone replacement therapy (HRT), affects the outcome of the treatment. The SLCO4A/OATP4A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341020 [Multi-domain]  Cd Length: 427  Bit Score: 301.75  E-value: 1.28e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 127 SRCFLVCMCFLTFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGGLLIA 206
Cdd:cd17462     1 PKGVLFFLCAASFLQGMTVNGFINTVITSIERRFDLRSYQSGLIASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLIMG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 207 FGAALFALPHFisppyqiqelnasapndglcqggnstatleppacpkdsggnnhwvyvALFICAQILIGMGSTPIYTLGP 286
Cdd:cd17462    81 LGSLVFALPHF-----------------------------------------------TVFMLGQFLHGIGATPLYTLGV 113
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 287 TYLDDNVKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFYVDPRNPVHLDQNDPRFIGNWWSGFLLCAIAMFLVIFPMF 366
Cdd:cd17462   114 TYLDENVKSNYSPVYIGIFYTAAIVGPAAGYLLGGFFLNIYTEIGRQTELTPENPLWVGAWWIGFLGAGAAALLIALPIL 193
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 367 TFpkklpprhkkkkkkkfsvdavsdddvlkeksnnseqadkkvssmgfgkdvrdlPRAAVRILSNMTFLFVSLSYTAESA 446
Cdd:cd17462   194 GY-----------------------------------------------------PRQLPGLLKNPTFIFLCLAGATEAT 220
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 447 IVTAFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFsTLFIVGC 526
Cdd:cd17462   221 LIAGMSTFGPKFLESQFSLSASEAATLFGYLVVPAGGGGTFLGGFIVNKLKLRCSGIIKFCLICTVVSLLAI-FIFSLHC 299
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 527 ESINLGGINIPYtTGPSLTMPHRNLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCVN-SGNLSTGIRNYTECTCVQ 605
Cdd:cd17462   300 PNVPMAGVTASY-RGSVLPEGSLNLTALCNADCRCLEEIYSPVCGADGLMYYSPCHAGCSEaYSDIRNGQKVYQDCSCVA 378
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034661683 606 srqvitpptvgqrsqlrvvivKTYLNENGYAVSGKCKRTCNTLIPFLVFLFIVTFITACAQPSAIIVTL 674
Cdd:cd17462   379 ---------------------GNLSVGFGEASAGKCTSNCNHMPLLLAFVFLVILFTFLCSIPALTATL 426
MFS_SLCO2B_OATP2B cd17460
Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of ...
130-672 7.76e-95

Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2B (SLCO2B), also called Organic anion-transporting polypeptide 2B (OATP2B), subfamily has one mammalian member, OATP2B1 (encoded by SLCO2B1). It mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. It also mediates the transport of endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). SLCO2B1 variations result in differential expression and uptake of DHEAS, which impacts subsequent resistance to androgen-deprivation therapy (ADT), the primary treatment of metastatic prostate cancer. The SLCO2B/OATP2B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341018 [Multi-domain]  Cd Length: 479  Bit Score: 301.69  E-value: 7.76e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 130 FLVCMCFLTFIQaLMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGGLLIAFGA 209
Cdd:cd17460     4 FVLCHGLLQLSQ-LLVSGYLKSSISTIEKRFGLSSQTSGLLASFNEVGNTVLIVFVSYFGSRVHRPRFIGCGAILVSLAG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 210 ALFALPHFISPPYQiqelnasapndglcqggnstatleppacpkdsggnnhwvYVALFIcAQILIGMGSTPIYTLGPTYL 289
Cdd:cd17460    83 FLMALPHFISEPYE---------------------------------------YGILFL-GQLLLGIGGVPIQPFGISYI 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 290 DDNVKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFYVD----PRNPVHLDQNDPRFIGNWWSGFLLCAIAMFLVIFPM 365
Cdd:cd17460   123 DDFASESNSPLYLGILFAVTVLGPGFGFMLGSAMLRFYVDidkmSEDEISLEIGDPRWVGAWWLGFLIAATLVALSAVPY 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 366 FTFPKKLPPRHKKKKKkkfsVDAVSDDDVLKEKSNNSEQAdKKVSSMGFgkdVRDLPRAAVRILSNMTFLFVSLSYTAES 445
Cdd:cd17460   203 FFFPREMPKEVVELQP----REKKLAKTMLKKLKSLSDIL-QNLSLLQF---IKKFPRILLRTLRNPIYLLVVLAQVNLS 274
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 446 AIVTAFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFSTLFIVG 525
Cdd:cd17460   275 AMVAGLATFMGKFLERQFSITASFANLMIGGLNIPSAMVGIVVGGVILKRLQLTVRGCGAMCVLGMLLCLFFALPLLFIG 354
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 526 CESINLGGINIPYTTGPSLTmphrnLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGC--VNSGNLSTGIRNYTECTC 603
Cdd:cd17460   355 CSTQKIAGITHRTSSSPGLE-----LSSQCSEACSCPPEAFNPVCGSDGVEYISPCHAGCksVNVQALDNSVVNYTDCSC 429
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034661683 604 VQSRQVITPptvgqrsqlrvvivktylnengyAVSGKCKRTC-NTLIPFLVFLFIVTFITACAQ-PSAIIV 672
Cdd:cd17460   430 VSEGGPVGA-----------------------ASPGTCGSGCsHLLVPFMLLVSLGGFLASLSHtPSFMLI 477
MFS_SLCO4C_OATP4C cd17463
Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of ...
130-671 1.45e-92

Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4C (SLCO4C), also called Organic anion-transporting polypeptide 4C (OATP4C), subfamily has one mammalian member, OATP4C1 (encoded by SLCO4C1). It is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. It is the only OATP expressed at the basolateral side of proximal tubular cells in human kidney and it mediates the excretion of uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs) and cause further progression of renal damage and cardiovascular diseases. Overexpression of human SLCO4C1 in rat kidney promotes the renal excretion of uremic toxins and reduces hypertension, cardiomegaly, and renal inflammation in renal failure. The SLCO4C/OATP4C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341021 [Multi-domain]  Cd Length: 429  Bit Score: 293.96  E-value: 1.45e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 130 FLVCMCFLTFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGGLLIAFGA 209
Cdd:cd17463     4 YLLFYSLLAVVQGIVVNGLVNISISTIEKRYELSSSLTGLISSSYDISFCLLSLFVSFYGERGHKPRWLAFSAFMIGLGS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 210 ALFALPHFIsppyqiqelnasapndglcqggnstatleppacpkdsggnnhwvyvaLFICAQILIGMGSTPIYTLGPTYL 289
Cdd:cd17463    84 LVFSLPHFF-----------------------------------------------VFILGQLLLGVGGTPLYTLGTAYI 116
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 290 DDNVKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFYVDPRNP--VHLDQNDPRFIGNWWSGFLLCAIAMFLVIFPMFT 367
Cdd:cd17463   117 DDSVPTHKSSLYIGIGYGMSVLGPAIGYLLGGQLLNIYIDVNKGqsVDLTEEDPRWLGAWWIGFLMCWLIAWCLIAPFSC 196
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 368 FpkklpprhkkkkkkkfsvdavsdddvlkeksnnseqadkkvssmgfgkdvrdlPRAAVRILSNMTFLFVSLSYTAESAI 447
Cdd:cd17463   197 F-----------------------------------------------------PKHLPGLLKNPVFMCLTISSCSEALI 223
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 448 VTAFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFSTLFIVGCE 527
Cdd:cd17463   224 TTGFATFLPKFIENQFGQTSSFAAILGGLVLIPGAAIGQILGGIIVSKFKLKCKNMIKFAIITTTVSLLLLSVFIFAKCG 303
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 528 SINLGGINIPYTTgpslTMPHRNLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCVNSgNLSTGIRNYTECTCVQSR 607
Cdd:cd17463   304 NDPFAGVSETYNG----TGKIGNLTAPCNANCSCLSSFYYPVCGADGVQYFSPCFAGCTNE-NLHDKKKVYYNCSCIGNF 378
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034661683 608 QVITPPTVGQrsqlrvvivktylnenGYAVsGKCKRTCNTLIPFLVFLFIV---TFITACAQPSAII 671
Cdd:cd17463   379 TEEFSANTTK----------------CEEG-KKCETTCKNLPIFLCFFFFVvifTFMTSTPITVAIL 428
MFS_SLCO3_OATP3 cd17402
Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of ...
128-672 4.07e-82

Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 3 (SLCO3) or Organic anion transporting polypeptide 3 (OATP3) family contains only one subfamily, OATP3A, which contains only one mammalian member OATP3A1 (encoded by SLCO3A1). It mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate, prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123, and vasopressin. SLCO3A1 has been identified as a Crohn's disease (CD)-associated gene, which mediates inflammatory processes in intestinal epithelial cells through NF-kappaB transcription activation, resulting in a higher incidence of bowel perforation in CD patients. The SLCO3/OATP3 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340960 [Multi-domain]  Cd Length: 444  Bit Score: 267.18  E-value: 4.07e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 128 RCFLVCMCFLTFIQAlMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGGLLIAF 207
Cdd:cd17402     2 KIFLVSECALMLAQG-TVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 208 GAALFALPHFISPPYQiqelnasapndglcqggnstatleppacpkdsggnNHWVYVaLFICAQILIGMGSTPIYTLGPT 287
Cdd:cd17402    81 GALLSALPEFLTHQYK-----------------------------------TNMMYL-LLIGAQVLLGIGATPVQPLGVS 124
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 288 YLDDNVKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFYVDP----RNPVHLDQNDPRFIGNWWSGFLLCAIAMFLVIF 363
Cdd:cd17402   125 YIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAvfidTSKLDITPDDPRWIGAWWGGFLLCGALLFFSAL 204
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 364 PMFTFPKKLpprhkkkkkkkfsvdavsdddvlkeksnnseqadkkvssmgfgKDVRDLPRAAVRILSNMTFLFVSLSYTA 443
Cdd:cd17402   205 LMFGFPQSL-------------------------------------------QQLRVIPKVTKHLLSNPVFTCIVLAACM 241
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 444 ESAIVTAFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFSTLFI 523
Cdd:cd17402   242 EIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLF 321
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 524 VGCESINLGGINIPYTtgpSLTMPHRNLT--GSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCVNSgnlstgirNYTEC 601
Cdd:cd17402   322 LGCDTGPVAGVTVPYG---NDTAPGSSLDpyAPCNSNCECQTDSFSPVCGADGITYLSACFAGCSST--------NLSGC 390
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034661683 602 TCVQsrqvitpptvgqrsqlrvvivkTYLNENGYAVSGKCKRT-C-NTLIPFLVFLFIVTFITACAQPSAIIV 672
Cdd:cd17402   391 ACLS----------------------SVPAENATVVPGKCPSPgCqEAFLTFLCVMCVCSMIGAMAQTPSVII 441
MFS_SLCO2A_OATP2A cd17461
Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of ...
128-605 7.49e-80

Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2A (SLCO2A), also called Organic anion-transporting polypeptide 2A (OATP2A), subfamily has one mammalian member, OATP2A1 (encoded by SLCO2A1), which is also called prostaglandin transporter. It is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Mutations in SLCO2A1 can cause primary hypertrophic osteoarthropathy (PHO), a rare multi-organic disease characterized by digital clubbing, pachydermia and periosteal reaction. The SLCO2A/OATP2A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341019 [Multi-domain]  Cd Length: 474  Bit Score: 262.05  E-value: 7.49e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 128 RCFLVCMCFLTFIQaLMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGGLLIAF 207
Cdd:cd17461     3 KVFVLCHGLLQLSQ-LLYSAYFKSSLTTIEKRFGLSSLSSGLISSLHEIGNAVLIIFVSYFGSRVHRPRLIGIGGLLLAL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 208 GAALFALPHFISPPYQIqelnasapndglcqggnstatleppacpkdsggnNHWVyvaLFICAQILIGMGSTPIYTLGPT 287
Cdd:cd17461    82 GAFLLTLPHFLSEPYQY----------------------------------SMWV---LMVVAQLLAGIGTVPIQPFGIS 124
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 288 YLDDNVKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFYVD----PRNPVHLDQNDPRFIGNWWSGFLLCAIAMFLVIF 363
Cdd:cd17461   125 YVDDFAEPSNSPLYIAILFAISVFGPAFGYLLGSVVLRIFVDigrvNTATVELTPADPRWIGAWWLGLLISSGLLVLTSL 204
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 364 PMFTFPKKLPPRHkkkkkkkfsvDAVSDDDVLKEKSnnsEQADKKVSSMGFgkdVRDLPRAAVRILSNMTFLFVSLSYTA 443
Cdd:cd17461   205 PYFFFPREMLVGK----------KPSPEGDMLRKKE---DEKKEEGSLLDF---IKRFPKMFVKLLLNPLFMLLVLAQCT 268
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 444 ESAIVTAFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFSTLFI 523
Cdd:cd17461   269 FSSVIAGLSTFLNKFLEKQYGASASYANFLIGAVNLPAAALGMLLGGIIMKRFGFSLRAIPRFSVVILSISIMLCVPLFF 348
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 524 VGCESINLGGINIPYTtgPSLTMPHRNltgsCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCVNSGNLSTG--IRNYTEC 601
Cdd:cd17461   349 MGCSTQDVAGVYPKTS--NSSDGPHLS----CSANCSCPESAFNPVCGENGIEYISPCHAGCTNSNMDSSTyrQQIYSNC 422

                  ....
gi 1034661683 602 TCVQ 605
Cdd:cd17461   423 SCIP 426
MFS_SLCO2_OATP2 cd17401
Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of ...
130-664 1.13e-77

Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2 (SLCO2) or Organic anion transporting polypeptide 2 (OATP2) family contains two subfamilies: OATP2A and OATP2B, each containing one mammalian member, OATP2A1 and OATP2B1, respectively. OATP2A1 (encoded by SLCO2A1) is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. OATP2B1 (encoded by SLCO2B1) mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost, as well as endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). The SLCO2/OATP2 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340959 [Multi-domain]  Cd Length: 440  Bit Score: 255.16  E-value: 1.13e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 130 FLVCMCFLTFIQaLMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGGLLIAFGA 209
Cdd:cd17401     4 FVLCHGLLQLCQ-LLYSGYLKSSITTIEKRFGLSSSSSGLLASFNEVGNTILIVFVSYFGSRVHRPRLIGIGGLFLAAGA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 210 ALFALPHFISPPYQiqelnasapndglcqggnstatleppacpkdsggnnhwvyVALFICAQILIGMGSTPIYTLGPTYL 289
Cdd:cd17401    83 FLLTLPHFISEPYQ----------------------------------------YGIMVVAQLLLGIGGVPIQPFGISYI 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 290 DDNVKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFYVD----PRNPVHLDQNDPRFIGNWWSGFLLCAIAMFLVIFPM 365
Cdd:cd17401   123 DDFAEPSNSPLYLGILFAVTVFGPAFGYLLGSVMLRLYVDigrmNTAAVNLVPGDPRWIGAWWLGFLIAAALLVLTSFPY 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 366 FTFPkklpprhkkkkkkkfsvdavsdddvlkeksnnseqadkkvssmgfgKDVRDLPRAAVRILSNMTFLFVSLSYTAES 445
Cdd:cd17401   203 FFFP----------------------------------------------RFIKRFPCIFLRTLRNPIFLLVVLAQVTLS 236
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 446 AIVTAFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFSTLFIVG 525
Cdd:cd17401   237 SMIAGLATFLNKFLEKQFGTTASYANFLIGAVNLPSAALGILFGGVLMKRLVLSLQAIPAICTTIITISMIFCVPLFFIG 316
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 526 CESINLGGINIPYTTGPSLTmphrnLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCVNSgNLSTGIRN----YTEC 601
Cdd:cd17401   317 CSTPTIAGVYPPSSSSSIHP-----QSPACRRDCSCPDSIFNPVCGDNGVEYLSPCHAGCSNI-NMSTSATSkqviYTNC 390
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034661683 602 TCVQSrqvitpptvgqrsqlrvvivktylnENGYAVSGKCKRTC-NTLIPFLVFLFIVTFItAC 664
Cdd:cd17401   391 SCVTG-------------------------GSASAKTGSCPSPCsHLLLPFIFLISLVSLI-AC 428
MFS_SLCO1A_OATP1A cd17458
Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of ...
137-674 4.71e-74

Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1A (SLCO1A), also called Organic anion-transporting polypeptide 1A (OATP1A), subfamily is composed of one human member OATP1A2 (encoded by SLCO1A2) and several rodent proteins encoded by the Slco1a1, Slco1a3, Slco1a4, Slco1a5, and Slco1a6 genes. OATP1A2, also known as human OATP-A or OATP1, shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). It is expressed in the brain, kidney, intestine, liver, lung, testes, and the eye (ciliary body). The SLCO1A/OATP1A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341016 [Multi-domain]  Cd Length: 527  Bit Score: 248.23  E-value: 4.71e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 137 LTFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGGLLIAFGAALFALPH 216
Cdd:cd17458    11 YAYVAKTLSGAYMNSMITQIERRFNIPSSLVGIINGSFEIGNLLVIAFVSYFGAKLHRPKVIGLGCLIMSLGCFLASLPH 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 217 FISPPYQIQELNASAPNDG----LC---QGGNSTATLEPPACPKDSGgNNHWVYValfICAQILIGMGSTPIYTLGPTYL 289
Cdd:cd17458    91 FLMGRYEYESTVSTTSNSSsrvpLClanQSLSHNVTQLPSECEKESM-SLMWIFV---LVGNLLRGIGETPVMPLGISYI 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 290 DDNVKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFYVD----PRNPVHLDQNDPRFIGNWWSGFLLCAIAMFLVIFPM 365
Cdd:cd17458   167 DDFSKKENSPFYIGCLHTATIVGPLLGLLLASFCAQLYVDlgsvNADDLTITPTDIRWVGAWWLGFLICAGVNFLAGLPF 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 366 FTFPKKLPPRHKKKKKKKFSVDAVSDDDvlkeksnnSEQADKKVSSMGFGKDVRDLPRAAVRILSNMTFLFVS-LSYTAe 444
Cdd:cd17458   247 WFLPKSLPKEGEENETEPSKTLTVELEE--------NKGQETKQEMYEIAKDFLPFLKSLFRNPIYMLFIIVTvLQFNA- 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 445 saiVTAFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFSTLFIV 524
Cdd:cd17458   318 ---FSGMISFMPKYLEQQYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKKFKINTYQAAHIGFWVSLLEYLLYFSAFWM 394
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 525 GCESINLGGINIPYTTGPSLTMPHRNLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCVNSgnLSTGIRN-YTECTC 603
Cdd:cd17458   395 GCDNSPVAGLTVSYEGIDQDSYYENTLLADCNRDCDCPLKVWDPVCGNNGLTYVSACLAGCKAS--VGTGKNMvFQNCSC 472
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034661683 604 VQSRQvitpptvgqrsqlrvvivktyLNENGYAVSGKCKR--TCNT-LIPFLVFLFIVTFITACAQPSAIIVTL 674
Cdd:cd17458   473 VAASG---------------------FPSQNSSAVGQCDKgeTCDKmLQYFLILSLVCSFIFSLAAMPGYMVLI 525
MFS_SLCO1C_OATP1C cd17459
Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of ...
130-663 5.35e-74

Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1C (SLCO1C), also called Organic anion-transporting polypeptide 1C (OATP1C), subfamily contains one mammalian member, OATP1C1 (encoded by SLCO1C1), which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine), as well as organic anions such as 17-beta-glucuronosyl estradiol, estrone-3-sulfate, and sulfobromophthalein (BSP), which are transported with much lower efficiency. The SLCO1C/OATP1C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341017 [Multi-domain]  Cd Length: 498  Bit Score: 247.37  E-value: 5.35e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 130 FLVCMCFLTFIQALmVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGGLLIAFGA 209
Cdd:cd17459     4 FLAALSFAYFAKAL-SGSYMKSTITQIERRFDIPSSLIGVIDGSFEMGNLLVIAFVSYFGAKLHRPRIIGAGCLLMAIGT 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 210 ALFALPHFISPPYQIQELNASAPNDGLCQGGNSTATLEPPA------------CPKDSgGNNHWVYVALficAQILIGMG 277
Cdd:cd17459    83 FLIALPHFFMGRYKYETAIQSSSNSTVSISPCSLEPSPQLHsiessdsktgtgCEKEP-GSSMWIYVFL---GNLLRGIG 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 278 STPIYTLGPTYLDDNVKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFYVD----PRNPVHLDQNDPRFIGNWWSGFLL 353
Cdd:cd17459   159 ETPVQPLGISYIDDFAKEENAAFYIGCVQTIAIIGPVFGFLLGSLCAKLYVDigfvNLDSITITPKDARWVGAWWLGYLI 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 354 CAIAMFLVIFPMFTFPkklpprhkkkkkkkfsvdavsdddvlkeksnnseqadkkvssmgfgkdvRDLPR----AAVRIL 429
Cdd:cd17459   239 AGVITLLSAVPFWFLP-------------------------------------------------KSLPKdflpSLKNLL 269
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 430 SN-MTFLFVSLSYTAESAIVtAFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAM 508
Cdd:cd17459   270 GNpVYFLYLCTSILQFNSLI-GMVTYKPKYIEQQYGQSASKANFLIGLINIPAVAIGIFSGGLLMKKFKLSVIGAAKLSF 348
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 509 ICSGVSLLCFSTLFIVGCESINLGGINIPYTTGPSLTMPHRNLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCVNS 588
Cdd:cd17459   349 GTSFFGYLLLLSFFAMGCENSDVAGLTVSYNGTKQVSYADRSLFSQCNADCKCSQKDWDPVCGENGITYVSPCLAGCKAS 428
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034661683 589 GNLSTGIRnYTECTCVQsrqvITPPTVGqrsqlrvvivktylneNGYAVSGKCKRT--CNTLIP-FLVFLFIVTFITA 663
Cdd:cd17459   429 NGSGKNTV-FHNCSCIG----IPSSASG----------------SSSAILGQCPKGnaCARMFLyFLAISVISSFTLS 485
MFS_SLCO1B_OATP1B cd17457
Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of ...
128-606 3.47e-68

Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1B (SLCO1B), also called organic anion-transporting polypeptide 1B (OATP1B), subfamily is composed of two human proteins, OATP1B1 (encoded by SLCO1B1) and OATP1B3 (encoded by SLCO1B3), and one rodent member, OATP1B2 (encoded by Slco1b2). OATP1B1 and OATP1B3 are almost exclusively expressed on the basal side of hepatocytes in normal human organs. They both can accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). Loss-of-function mutations in both SLCO1B1 and SLCO1B3 genes result in the Rotor syndrome, a hereditary hyperbilirubinemia. The SLCO1B/OATP1B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341015 [Multi-domain]  Cd Length: 455  Bit Score: 230.50  E-value: 3.47e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 128 RCFLVCMCFLTFIQALMVSgYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGGLLIAF 207
Cdd:cd17457     2 KMFLAALSFSYFAKALSGI-IMKSSITQIERRFDISSSTVGFIDGSFEIGNLLVIAFVSYFGAKLHRPKLIAAGCFIMGL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 208 GAALFALPHFISPPYQIqelnasapndglcqggnstatleppACPKDSGgNNHWVYVALficAQILIGMGSTPIYTLGPT 287
Cdd:cd17457    81 GSVLTALPHFFMGYYKY-------------------------GCLKESG-SYMWVYVLM---GNMLRGIGETPIVPLGIS 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 288 YLDDNVKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFYVD----PRNPVHLDQNDPRFIGNWWSGFLLCAIAMFLVIF 363
Cdd:cd17457   132 YLDDFAKEENSPLYLACLHTIAMIGPMIGFTLGSLFAKLYVDigfvDLSTIRITPQDSRWVGAWWLGFLVSGLFSIISAI 211
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 364 PMFTFPkklpprhkkkkkkkfsvdavsdddvlkeksnnseqadkkvssmGFGKDVRdlpraavRILSNMTF-LFVSLSYT 442
Cdd:cd17457   212 PFFFLP-------------------------------------------GFFQSLK-------SILTNRLYvMFVCLTLL 241
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 443 AESAIVtAFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFSTLF 522
Cdd:cd17457   242 QVSSFI-GFFTYKPKYMEQQYGQSSSKANFLLGVITLPIFASGMFLGGYIMKKYKLNTVGAAKFACFTSVMALSFYLLYF 320
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 523 IVGCESINLGGINIPYTTGPSLTMPHRNLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCVNSGNLSTGIRnYTECT 602
Cdd:cd17457   321 FIGCENKSVAGITMTYDGNNPVTSHRDVILSYCNSDCNCDESQWDPVCGNNGITYISACLAGCKSSSGNGKPIV-FHNCS 399

                  ....
gi 1034661683 603 CVQS 606
Cdd:cd17457   400 CLEV 403
MFS_SLCO1_OATP1 cd17400
Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of ...
132-605 5.57e-65

Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1 (SLCO1) or Organic anion transporting polypeptide 1 (OATP1) family contains three subfamilies: OATP1A, OATP1B, and OATP1C. OATP1A contains one human member, OATP1A2, which shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). OATP1B contains two human proteins, OATP1B1 and OATP1B3, which can both accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). OATP1C contains one mammalian member, OATP1C1, which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine). The SLCO1/OATP1 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340958 [Multi-domain]  Cd Length: 436  Bit Score: 221.24  E-value: 5.57e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 132 VCMCFLTFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGGLLIAFGAAL 211
Cdd:cd17400     5 LLALSCAFVAKTLSGSYMKSMITQIERRFNIPSSLVGFIDGSFEIGNLLVIIFVSYFGTKLHRPKMIGIGCVIMGLGCFL 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 212 FALPHFISPPYQIQELnasapndglcqggnstatleppacpkdsggnnhWVYVALficAQILIGMGSTPIYTLGPTYLDD 291
Cdd:cd17400    85 KALPHFFMNQYEYSLM---------------------------------WIYVFV---GNILRGIGETPILPLGISYIDD 128
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 292 NVKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFYVDPrNPVHLDQ-----NDPRFIGNWWSGFLLCAIAMFLVIFPMF 366
Cdd:cd17400   129 FAKEENSPLYIGLVETGAIIGPIIGFLLGSLCAKVYVDI-GFVNLDDiiitpTDTRWVGAWWLGFLICGGVSVLTAIPFF 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 367 tfpkklpprhkkkkkkkfsvdavsdddvlkeksnnseqadkkvssmgfgkdvrdlpraavrILSNMTFLFVSLSYTAESA 446
Cdd:cd17400   208 -------------------------------------------------------------FLPPIYMLFILVSVIQFNS 226
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 447 IVTAFiTFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFSTLFIVGC 526
Cdd:cd17400   227 FVGMI-TYMPKYLEQQYGQSSSDANFLMGIINIPPIAIGYFIGGLIMKKFKITVKGAAKIGCWLSVLEYLLYLLSFLMTC 305
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034661683 527 ESINLGGINIPYTTGPSLTMPHRNLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCVNSGNLSTGIRNYTeCTCVQ 605
Cdd:cd17400   306 ENSSVAGLTTSYEGIPPVLYHENDIFSDCNSDCNCPEKIWEPVCGNNGITYLSACLAGCETSIGTGKNIVFYN-CSCIQ 383
MFS_SLCO6_OATP6 cd17405
Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of ...
128-673 3.22e-50

Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 6 (SLCO6) or Organic anion transporting polypeptide 6 (OATP6) family contains only one subfamily, OATP6A, which contains only one human member OATP6A1 (encoded by SLCO6A1). The OATP6 family is the most diverged of the OATPs. OATP6A1 is also called cancer/testis antigen 48 (CT48) or gonad-specific transporter. It is strongly expressed only in normal testis, and weakly in spleen, brain, fetal brain, and placenta. It is found in tumor samples (lung, bladder, and esophageal) and cancer cell lines (lung), and may be of potential use as a target for therapy for a variety of tumor types. The SLCO6/OATP6 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340963 [Multi-domain]  Cd Length: 428  Bit Score: 180.81  E-value: 3.22e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 128 RCFLVCMCFLTFIQALmVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGGLLIAF 207
Cdd:cd17405     2 DGFMILYCILVLIQGA-VFGLVDMSIGIFQVQFSLTRTEKYLLDFSYDISSFLVAIIIAHYGSRGNRTRWIAASCFLMGL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 208 GAALFALPhfisppyqiqelnasapndglcqggnstatleppacpkdsggnnhwvYVALFICAQILIGMGSTPIYTLGPT 287
Cdd:cd17405    81 GSMLFAFP-----------------------------------------------FFTFHIAGQCIQGIAGMPIYILGIT 113
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 288 YLDDNVKKENSSLYLAI---MYVMG-ALGPAVGYLLGGLLIGFYVDPRNPvhlDQNDPRFIGNWWSGFLLCAIAMFLVIF 363
Cdd:cd17405   114 FIFDNIPTSSAGIYLGIahsAYLIGyLLGYVGGLPNFQPPPNEKSVEIEV---NKVYQLWQSGWWKTFLIAAAIAWCTSF 190
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 364 PMFTFpkklpprhkkkkkkkfsvdavsdddvlkeksnnseqadkkvssmgfgkdvrdlPRAAVRILSNMTFLFVSLSYTA 443
Cdd:cd17405   191 PLVCF-----------------------------------------------------PTSLPGLLKNPLLLCQAICKAT 217
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 444 ESAIVTAFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIKKLKLGARESAKLAMICSGVSLLCFSTLFI 523
Cdd:cd17405   218 EYLTFIGALEFLPHYLENQFLLTPGIASLLTGAFLIPGGAIGHFLGGLIVSRLEMSCKNKMRFILVTSVISLGLFVLIFF 297
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 524 VGCESINLGGINIPYTTGPSLTmphrNLTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCVNSGNLSTGiRNYTECTC 603
Cdd:cd17405   298 VECQTVTFAGINEDYDGYGQLG----NLTAPCNEYCDCTSSLYTSICGRDEIEYFSPCFAGCKASKVSNTE-KTYYNCSC 372
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034661683 604 VQsRQVITPPTVGQRSQlrvvivktylnengyAVSGKCKRTCNTLIPFLVFLFIVT-FITACAQPSAIIVT 673
Cdd:cd17405   373 IK-EGLAAADDEGDFID---------------AIAGKCDSKCYKLPLFFAFYFSATvFSNMCSIPIILIIL 427
KAZAL_SLC21 cd01330
The kazal-type serine protease inhibitor domain has been detected in an extracellular loop ...
551-605 2.54e-22

The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a member of the superfamily of kazal-like proteinase inhibitors and follistatin-like proteins.


Pssm-ID: 238650 [Multi-domain]  Cd Length: 54  Bit Score: 90.44  E-value: 2.54e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1034661683 551 LTGSCNVNCGCKIHEYEPVCGSDGITYFNPCLAGCVNSgNLSTGIRNYTECTCVQ 605
Cdd:cd01330     1 LTSSCNSNCSCSESAYSPVCGENGITYFSPCHAGCTNS-TGSGGSKIYTNCSCVG 54
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
131-526 6.00e-12

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 67.84  E-value: 6.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 131 LVCMCFLTFIQALMVSGYLssviTTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGGLLIAFGAA 210
Cdd:cd06174     1 LLLGFFLTGLARGLISPLL----PALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGAL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 211 LFALPHfisppyqiqelnasapndglcqggnstatleppacpkdsggnnhwvYVALFICAQILIGMGSTPIYTLGPTYLD 290
Cdd:cd06174    77 LFAFAP----------------------------------------------SFWLLLLGRFLLGLGSGLIDPAVLALIA 110
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 291 DNVKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFyvdprnpvhldqndprFIGNWWSGFLLCAIAMFLVIFPMFTFpk 370
Cdd:cd06174   111 DLFPERERGRALGLLQAFGSVGGILGPLLGGILASS----------------LGFGWRAVFLIAAALALLAAILLLLV-- 172
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 371 klpprhkkkkkkkfsvdavsdddvLKEKSNNSEQADKKVSSMGFGKDVRdlpraavRILSNMTFLFVSLSYTAESAIVTA 450
Cdd:cd06174   173 ------------------------VPDPPESARAKNEEASSKSVLKLLK-------RVLKNPGLWLLLLAIFLVNLAYYS 221
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034661683 451 FITFIPKFIESQFGIPASNASIYTGVIIVPSAgVGIVLGGYIIKKLKLGAResakLAMICSGVSLLCFSTLFIVGC 526
Cdd:cd06174   222 FSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGA-LGSLLLGLLSDRLIGRKP----LLLIGLLLMALGLALLLLAPS 292
Kazal_2 pfam07648
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
556-603 7.59e-12

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.


Pssm-ID: 400135  Cd Length: 50  Bit Score: 60.58  E-value: 7.59e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1034661683 556 NVNCGCKIHEYEPVCGSDGITYFNPC---LAGCVNSGNLStGIRNYTECTC 603
Cdd:pfam07648   1 NCNCQCPKTEYEPVCGSDGVTYPSPCalcAAGCKLGKEVK-EEKVKYDGSC 50
KAZAL_FS cd00104
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...
565-603 2.00e-10

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the cognate enzyme as substrate. The reactive site peptide bond is a combining loop which has an identical conformation in all Kazal inhibitors and in all enzyme/inhibitor complexes. These Kazal domains (small hydrophobic core of alpha/beta structure with 3 to 4 disulfide bonds) often occur in tandem arrays. Similar domains are also present in follistatin (FS) and follistatin-like family members, which play an important role in tissue specific regulation. The FS domain consists of an N-terminal beta hairpin (FOLN/EGF-like domain) and a Kazal-like domain and has five disulfide bonds. Although the Kazal-like FS substructure is similar to Kazal proteinase inhibitors, no FS domain has yet been shown to be a proteinase inhibitor. Follistatin-like family members include SPARC, also known as, BM-40 or osteonectin, the Gallus gallus Flik protein, as well as, agrin which has a long array of FS domains. The kazal-type inhibitor domain has also been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The distant homolog, Ascidian trypsin inhibitor, is included in this CD.


Pssm-ID: 238052 [Multi-domain]  Cd Length: 41  Bit Score: 56.12  E-value: 2.00e-10
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1034661683 565 EYEPVCGSDGITYFNPCLAGCVNSgNLSTGIRNYTECTC 603
Cdd:cd00104     4 EYDPVCGSDGKTYSNECHLGCAAC-RSGRSITVAHNGPC 41
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
149-528 7.05e-08

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 55.32  E-value: 7.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 149 LSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPlWLAVGGLLIaFGAALFALPhFISppyqiqeln 228
Cdd:cd17328    18 IAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRK-WILAVGILI-WSAATLLSS-FAP--------- 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 229 asapndglcqggnstatleppacpkdsggnnhwvYVALFICAQILIGMGSTPIYTLGPTYLDDNVKKENSSLYLAIMYVM 308
Cdd:cd17328    86 ----------------------------------NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFA 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 309 GALGPAVGyllgglligfYVDPRNPVHLdqndprfIGNWWSGFLLCAIAMFLVIFPMFTFpkklpprhkkkkkkkfsvda 388
Cdd:cd17328   132 IPLGSGLG----------YVVGGLVAQA-------TGGWRWAFRVTGVLGVLLAILLLLF-------------------- 174
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 389 VSDddvlKEKSNNSEQADKKVSSMGFGKDVRDLpraavriLSNMTFLFVSLSYTAESAIVTAFITFIPKFIESQFGI--- 465
Cdd:cd17328   175 VRE----PPRGAAEGGVMAKSTATSFLADLKAL-------AKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVgdl 243
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034661683 466 PASNASIYTGVIIVPSAGVGIVLGGYIIKKLKlgARESAKLAMICSGVSLLC--FSTLFIVGCES 528
Cdd:cd17328   244 SSADVGLIFGAITCIAGVLGVLLGGILADRLR--RKTPRADPLVCAVGLLAAapFLFLALVLALS 306
MFS_1 pfam07690
Major Facilitator Superfamily;
134-531 3.26e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 52.81  E-value: 3.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 134 MCFLTFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGR-GRRPLWLAvGGLLIAFGAALF 212
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRfGRRRVLLI-GLLLFALGLLLL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 213 ALPHfisppyqiqelnasapndglcqggnstatleppacpkdsggnNHWVYVALFIcaqiLIGMGSTPIYTLGPTYLDDN 292
Cdd:pfam07690  80 LFAS------------------------------------------SLWLLLVLRV----LQGLGAGALFPAALALIADW 113
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 293 VKKENSSLYLAIMYVMGALGPAVGYLLGGLLIGFYvdprnpvhldqndprfigNWWSGFLLCAIAMFLVIFPMFTFpkkl 372
Cdd:pfam07690 114 FPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF------------------GWRAAFLILAILSLLAAVLLLLP---- 171
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 373 pprhkkkkkkkfsvdavsddDVLKEKSNNSEQADKKVSSMGFGKDVRDLPRaavrilsnMTFLFVSLSYtaeSAIVTAFI 452
Cdd:pfam07690 172 --------------------RPPPESKRPKPAEEARLSLIVAWKALLRDPV--------LWLLLALLLF---GFAFFGLL 220
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034661683 453 TFIPKFIEsQFGIPASNASIYTGVIIVpSAGVGIVLGGYIIKKLKLGAResakLAMICSGVSLLCFSTLFIVGCESINL 531
Cdd:pfam07690 221 TYLPLYQE-VLGLSALLAGLLLGLGGL-LGAIGRLLLGRLSDRLGRRRR----LLLALLLLILAALGLLLLSLTLSSLW 293
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
433-554 3.44e-05

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 46.41  E-value: 3.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 433 TFLFVSLSYTAESAIVTAFITFIPKFIESQFGIPASNASIYTGVIIVPSAgVGIVLGGYIIKKLKLGAResAKLAMI--- 509
Cdd:cd17319   180 QVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGA-IGMILGGRLSDRLLRGAR--RLVIIIgll 256
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1034661683 510 CSGVSLLC----FSTLFIVGCESINLGGINIPYTTGPSL--TMPHRNLTGS 554
Cdd:cd17319   257 LAAVGLLLayltTSPVVAVILLSLAGFGIGAASPVFWSLpaDLLPGEAAAT 307
KAZAL_PSTI cd01327
Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the ...
560-603 1.20e-04

Kazal-type pancreatic secretory trypsin inhibitors (PSTI) and related proteins, including the second domain of the ovomucoid turkey inhibitor and the C-terminal domain of the esophagus cancer-related gene-2 protein (ECRG-2), are members of the superfamily of kazal-type proteinase inhibitors and follistatin-like proteins.


Pssm-ID: 238648  Cd Length: 45  Bit Score: 39.96  E-value: 1.20e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1034661683 560 GCKIHeYEPVCGSDGITYFNPCLAgCVNSGNLSTGIRNYTECTC 603
Cdd:cd01327     4 GCPKD-YDPVCGTDGVTYSNECLL-CAENLKRQTNIRIKHDGEC 45
KAZAL smart00280
Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...
565-592 2.22e-04

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.


Pssm-ID: 197624  Cd Length: 46  Bit Score: 39.20  E-value: 2.22e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1034661683  565 EYEPVCGSDGITYFNPC---LAGCVNSGNLS 592
Cdd:smart00280   9 EYDPVCGSDGVTYSNEChlcKAACESGKSIE 39
MFS_1 pfam07690
Major Facilitator Superfamily;
134-315 4.01e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.18  E-value: 4.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 134 MCFLTFIQALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGR-GRRPLWLAVGGLLIAFGAALF 212
Cdd:pfam07690 204 WLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRlGRRRRLLLALLLLILAALGLL 283
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 213 ALPHFISPpyqiqelnasapndglcqggnstatleppacpkdsggnnHWVYVALFicaqiLIGMGSTPIYTLGPTYLDDN 292
Cdd:pfam07690 284 LLSLTLSS---------------------------------------LWLLLALL-----LLGFGFGLVFPALNALVSDL 319
                         170       180
                  ....*....|....*....|...
gi 1034661683 293 VKKENSSLYLAIMYVMGALGPAV 315
Cdd:pfam07690 320 APKEERGTASGLYNTAGSLGGAL 342
Kazal_1 pfam00050
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
565-582 4.29e-04

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides. Alignment also includes a single domain from transporters in the OATP/PGT family.


Pssm-ID: 395004  Cd Length: 49  Bit Score: 38.42  E-value: 4.29e-04
                          10
                  ....*....|....*...
gi 1034661683 565 EYEPVCGSDGITYFNPCL 582
Cdd:pfam00050  12 IYDPVCGTDGKTYSNECL 29
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
414-554 5.94e-04

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 42.56  E-value: 5.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 414 FGKDVRDLPRAAVRILSNMTFLFVSLSYTAESAIVTAFITFIPKFIESQFGIPASNASIYTGVIIvpsagVGIVLGGYII 493
Cdd:cd17320   183 RKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNA-----IALILGSLLN 257
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034661683 494 KKL--KLGARESAKLAMICSGVSLLCFSTLFIVGCESIN---------LGGINIPYTTGPSLTM-PHRNLTGS 554
Cdd:cd17320   258 GRLvrRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWplvaplfliFFGFGLIFPNATSLALePFPHVAGT 330
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
434-522 2.50e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 40.66  E-value: 2.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 434 FLFVSLSYTAESAIVTAFITFIPKFIESQFGIPASNASIYTGVIIVpSAGVGIVLGGYIIKklKLGARESAKLAMICSGV 513
Cdd:cd17316   179 TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISL-GALVGALIAGLLSD--RIGRKKTLVIGLILSGI 255

                  ....*....
gi 1034661683 514 SLLCFSTLF 522
Cdd:cd17316   256 LALPLFYLL 264
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
135-519 3.97e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 39.87  E-value: 3.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 135 CFLTFIqALMVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGR-GRRPLwLAVGGLLIAFGAALFA 213
Cdd:cd17325     2 SLALFL-DMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRfGRKRL-LLLGLLLLAVSTLLFA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 214 LphfisppyqiqelnasAPNdglcqggnstatleppacpkdsggnnhwvyVALFICAQILIGMGSTPIYTLGPTYLDDNV 293
Cdd:cd17325    80 F----------------ATS------------------------------YWQLLLARFLQGLASAAVWPAAMALIADIA 113
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 294 KKENS----SLYLAIMYVMGALGPAVGYllgglligfyvdprnpvhldqndprFIGNWWS---GFLLCAIAMFLVIFPMF 366
Cdd:cd17325   114 PPEERgramGIFSSAIGLGFLIGPLLGG-------------------------LLADALGyraPFLVCAALALLALVLAL 168
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034661683 367 TFpkklpprhkkkkkkkfsvdavsdddvLKEKSNNSEQADKKVSSMGFGKDvrdlpraavRILSNMTFLFVSLSYTAESA 446
Cdd:cd17325   169 LL--------------------------LPEPRPPPNKRAVSAARLRSGLR---------LLLRDRRLLALFLAIFVLAF 213
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034661683 447 IVTAFITFIPKFIESQFGIPASNASIYTGVIIVPSAGVGIVLGGYIIkklKLGARESAKLAMICSGVSLLCFS 519
Cdd:cd17325   214 AFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSD---RIGRKPLILIGLLLSAVALLLLP 283
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
144-214 8.58e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 39.08  E-value: 8.58e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034661683 144 MVSGYLSSVITTIERRYSLKSSESGLLVSCFDIGNLVVVVFVSYFGGRGRRPLWLAVGGLLIAFGAALFAL 214
Cdd:cd17478    10 FYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGF 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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