|
Name |
Accession |
Description |
Interval |
E-value |
| TLE_N |
pfam03920 |
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ... |
18-77 |
8.78e-47 |
|
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.
Pssm-ID: 461094 Cd Length: 117 Bit Score: 161.44 E-value: 8.78e-47
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 18 FKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHK 77
Cdd:pfam03920 1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHK 60
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
437-722 |
1.65e-43 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 162.00 E-value: 1.65e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 437 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDISHPGNKSPVSqldclNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAa 515
Cdd:COG2319 77 HTAAVLSVAFSPDGRLLASASAdGTVRLWDLATGLLLRTLT-----GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA- 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 516 pTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVR 595
Cdd:COG2319 151 -TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVR 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 596 SWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPD-KYQLHLHESCVLSLKFAYCGKWFVSTGKD 673
Cdd:COG2319 230 LWDLATGKLLRTlTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGElLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1034671132 674 NLLNAWRTPYGASIFQSK-ESSSVLSCDISVDDKYIVTGSGDKKATVYEV 722
Cdd:COG2319 310 GTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
437-721 |
7.20e-38 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 142.86 E-value: 7.20e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 437 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDIShpgNKSPVSQLdCLNRDNyIRSCKLLPDGCTLIVGGEASTLSIWDLaa 515
Cdd:cd00200 8 HTGGVTCVAFSPDGKLLATGSGdGTIKVWDLE---TGELLRTL-KGHTGP-VRDVAASADGTYLASGSSDKTIRLWDL-- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 516 PTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVR 595
Cdd:cd00200 81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 596 SWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPD-KYQLHLHESCVLSLKFAYCGKWFVSTGKD 673
Cdd:cd00200 161 LWDLRTGKCVATlTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKcLGTLRGHENGVNSVAFSPDGYLLASGSED 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1034671132 674 NLLNAWRTPYGASIFQ-SKESSSVLSCDISVDDKYIVTGSGDKKATVYE 721
Cdd:cd00200 241 GTIRVWDLRTGECVQTlSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
559-598 |
4.28e-07 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 46.92 E-value: 4.28e-07
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1034671132 559 NQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 598
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
549-720 |
8.07e-07 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 52.40 E-value: 8.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 549 DGNIAVWDLHNQTLVRQFQGHTDGASCIDISN-DGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGY-CPTGEWL 626
Cdd:PLN00181 554 EGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFpSESGRSL 633
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 627 AVGMESSNVEVLHVNKPdkyQLHL-----HESCVLSLKFAYCGKwFVSTGKDNLLNAWRTPYGASIFQSKESSSVLS--- 698
Cdd:PLN00181 634 AFGSADHKVYYYDLRNP---KLPLctmigHSKTVSYVRFVDSST-LVSSSTDNTLKLWDLSMSISGINETPLHSFMGhtn 709
|
170 180
....*....|....*....|....*.
gi 1034671132 699 ----CDISVDDKYIVTGSGDKKATVY 720
Cdd:PLN00181 710 vknfVGLSVSDGYIATGSETNEVFVY 735
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
561-598 |
5.46e-06 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 43.49 E-value: 5.46e-06
10 20 30
....*....|....*....|....*....|....*...
gi 1034671132 561 TLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 598
Cdd:pfam00400 2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
273-430 |
7.60e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 43.00 E-value: 7.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 273 TPTPRSDMPTPGTSATPGLRPGLGKPPA--IDPLVNQAAAGLRTPLAV--PGPYPAPFG-------MVPHAGMNGELTSP 341
Cdd:PHA03247 2707 TPEPAPHALVSATPLPPGPAAARQASPAlpAAPAPPAVPAGPATPGGParPARPPTTAGppapappAAPAAGPPRRLTRP 2786
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 342 GAAYASLHNMSPQMSAAAAAAAVVAYGRSPMV-------GFDPPPHMRVPTIPPNLAGIPGGKPAYSFHVTADGQMQPVP 414
Cdd:PHA03247 2787 AVASLSESRESLPSPWDPADPPAAVLAPAAALppaaspaGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRP 2866
|
170
....*....|....*.
gi 1034671132 415 FPPDALIGPGIPRHAR 430
Cdd:PHA03247 2867 PSRSPAAKPAAPARPP 2882
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
146-417 |
3.18e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 40.91 E-value: 3.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 146 RDREPGTSNSllvPDSLRGTDKRRNGPEFSndikkRKVDDKDSSHYDSDGDKSDDNLVVDVSNEDPSSPRASPA-HSPRE 224
Cdd:pfam03154 82 RQREKGASDT---EEPERATAKKSKTQEIS-----RPNSPSEGEGESSDGRSVNDEGSSDPKDIDQDNRSTSPSiPSPQD 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 225 NGIDKNRLLKKDAssspastassasstsLKSKEMSLHEKASTPVLKSSTPTPRSDMPTPG-TSATPGLRPGLGKPPAIDP 303
Cdd:pfam03154 154 NESDSDSSAQQQI---------------LQTQPPVLQAQSGAASPPSPPPPGTTQAATAGpTPSAPSVPPQGSPATSQPP 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 304 LVNQAAAGLRT---------PLAVPGPYPAPFGMVPHAGMNGELTSPGAAyASLHNMSPQMSAAAAAAAVVAYGRSPMVG 374
Cdd:pfam03154 219 NQTQSTAAPHTliqqtptlhPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQ-PSLHGQMPPMPHSLQTGPSHMQHPVPPQP 297
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 1034671132 375 FDPPPHMRVPTIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPP 417
Cdd:pfam03154 298 FPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPP 340
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| TLE_N |
pfam03920 |
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ... |
18-77 |
8.78e-47 |
|
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.
Pssm-ID: 461094 Cd Length: 117 Bit Score: 161.44 E-value: 8.78e-47
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 18 FKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHK 77
Cdd:pfam03920 1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHK 60
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
437-722 |
1.65e-43 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 162.00 E-value: 1.65e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 437 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDISHPGNKSPVSqldclNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAa 515
Cdd:COG2319 77 HTAAVLSVAFSPDGRLLASASAdGTVRLWDLATGLLLRTLT-----GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA- 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 516 pTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVR 595
Cdd:COG2319 151 -TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVR 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 596 SWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPD-KYQLHLHESCVLSLKFAYCGKWFVSTGKD 673
Cdd:COG2319 230 LWDLATGKLLRTlTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGElLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1034671132 674 NLLNAWRTPYGASIFQSK-ESSSVLSCDISVDDKYIVTGSGDKKATVYEV 722
Cdd:COG2319 310 GTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
437-722 |
3.20e-42 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 158.54 E-value: 3.20e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 437 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDIShpgNKSPVSQLDclNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAa 515
Cdd:COG2319 119 HTGAVRSVAFSPDGKTLASGSAdGTVRLWDLA---TGKLLRTLT--GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA- 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 516 pTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVR 595
Cdd:COG2319 193 -TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 596 SWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDK-YQLHLHESCVLSLKFAYCGKWFVSTGKD 673
Cdd:COG2319 272 LWDLATGELLRTlTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKTLASGSDD 351
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1034671132 674 NLLNAWRTPYGASIFQSKE-SSSVLSCDISVDDKYIVTGSGDKKATVYEV 722
Cdd:COG2319 352 GTVRLWDLATGELLRTLTGhTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
437-721 |
7.20e-38 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 142.86 E-value: 7.20e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 437 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDIShpgNKSPVSQLdCLNRDNyIRSCKLLPDGCTLIVGGEASTLSIWDLaa 515
Cdd:cd00200 8 HTGGVTCVAFSPDGKLLATGSGdGTIKVWDLE---TGELLRTL-KGHTGP-VRDVAASADGTYLASGSSDKTIRLWDL-- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 516 PTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVR 595
Cdd:cd00200 81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 596 SWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPD-KYQLHLHESCVLSLKFAYCGKWFVSTGKD 673
Cdd:cd00200 161 LWDLRTGKCVATlTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKcLGTLRGHENGVNSVAFSPDGYLLASGSED 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1034671132 674 NLLNAWRTPYGASIFQ-SKESSSVLSCDISVDDKYIVTGSGDKKATVYE 721
Cdd:cd00200 241 GTIRVWDLRTGECVQTlSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
430-682 |
1.31e-37 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 145.05 E-value: 1.31e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 430 RQINTLN-HGEVVCAVTISNPTRHVYTGGK-GCVKVWDIShpgNKSPVSQLDclNRDNYIRSCKLLPDGCTLIVGGEAST 507
Cdd:COG2319 153 KLLRTLTgHSGAVTSVAFSPDGKLLASGSDdGTVRLWDLA---TGKLLRTLT--GHTGAVRSVAFSPDGKLLASGSADGT 227
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 508 LSIWDLAapTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWT 587
Cdd:COG2319 228 VRLWDLA--TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 588 GGLDNTVRSWDLREGRQLQQHD-FTSQIFSLGYCPTGEWLAVGMESSNVEVLHVN-KPDKYQLHLHESCVLSLKFAYCGK 665
Cdd:COG2319 306 GSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAtGELLRTLTGHTGAVTSVAFSPDGR 385
|
250
....*....|....*..
gi 1034671132 666 WFVSTGKDNLLNAWRTP 682
Cdd:COG2319 386 TLASGSADGTVRLWDLA 402
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
487-722 |
5.54e-30 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 123.10 E-value: 5.54e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 487 IRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPacYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQF 566
Cdd:COG2319 39 VASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV--LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 567 QGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDK 645
Cdd:COG2319 117 TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTlTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL 196
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034671132 646 YQ-LHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSK-ESSSVLSCDISVDDKYIVTGSGDKKATVYEV 722
Cdd:COG2319 197 LRtLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
531-722 |
7.82e-26 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 108.19 E-value: 7.82e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 531 CYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ-HD 609
Cdd:cd00200 12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTlTG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 610 FTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPD-KYQLHLHESCVLSLKFAyCGKWFVSTGK-DNLLNAWRTPYGASI 687
Cdd:cd00200 92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKcLTTLRGHTDWVNSVAFS-PDGTFVASSSqDGTIKLWDLRTGKCV 170
|
170 180 190
....*....|....*....|....*....|....*..
gi 1034671132 688 --FQSkESSSVLSCDISVDDKYIVTGSGDKKATVYEV 722
Cdd:cd00200 171 atLTG-HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL 206
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
562-722 |
7.55e-20 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 90.47 E-value: 7.55e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 562 LVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREG---RQLQQHdfTSQIFSLGYCPTGEWLAVGMESSNVEVL 638
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGellRTLKGH--TGPVRDVAASADGTYLASGSSDKTIRLW 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 639 HVNKPDK-YQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASI--FQSKEsSSVLSCDISVDDKYIVTGSGDK 715
Cdd:cd00200 79 DLETGECvRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLttLRGHT-DWVNSVAFSPDGTFVASSSQDG 157
|
....*..
gi 1034671132 716 KATVYEV 722
Cdd:cd00200 158 TIKLWDL 164
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
505-722 |
3.89e-19 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 90.36 E-value: 3.89e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 505 ASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTK 584
Cdd:COG2319 13 SADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 585 LWTGGLDNTVRSWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDK-YQLHLHESCVLSLKFAY 662
Cdd:COG2319 93 LASASADGTVRLWDLATGLLLRTlTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLlRTLTGHSGAVTSVAFSP 172
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034671132 663 CGKWFVSTGKDNLLNAWRTPYGASIFQ-SKESSSVLSCDISVDDKYIVTGSGDKKATVYEV 722
Cdd:COG2319 173 DGKLLASGSDDGTVRLWDLATGKLLRTlTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
430-559 |
6.20e-12 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 68.01 E-value: 6.20e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 430 RQINTLN-HGEVVCAVTISNPTRHVYTGGKGC-VKVWDIShpgNKSPVSQLDclNRDNYIRSCKLLPDGCTLIVGGEAST 507
Cdd:COG2319 279 ELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGtVRLWDLA---TGKLLRTLT--GHTGAVRSVAFSPDGKTLASGSDDGT 353
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1034671132 508 LSIWDLAapTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHN 559
Cdd:COG2319 354 VRLWDLA--TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
559-598 |
4.28e-07 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 46.92 E-value: 4.28e-07
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1034671132 559 NQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 598
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
549-720 |
8.07e-07 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 52.40 E-value: 8.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 549 DGNIAVWDLHNQTLVRQFQGHTDGASCIDISN-DGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGY-CPTGEWL 626
Cdd:PLN00181 554 EGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFpSESGRSL 633
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 627 AVGMESSNVEVLHVNKPdkyQLHL-----HESCVLSLKFAYCGKwFVSTGKDNLLNAWRTPYGASIFQSKESSSVLS--- 698
Cdd:PLN00181 634 AFGSADHKVYYYDLRNP---KLPLctmigHSKTVSYVRFVDSST-LVSSSTDNTLKLWDLSMSISGINETPLHSFMGhtn 709
|
170 180
....*....|....*....|....*.
gi 1034671132 699 ----CDISVDDKYIVTGSGDKKATVY 720
Cdd:PLN00181 710 vknfVGLSVSDGYIATGSETNEVFVY 735
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
561-598 |
5.46e-06 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 43.49 E-value: 5.46e-06
10 20 30
....*....|....*....|....*....|....*...
gi 1034671132 561 TLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 598
Cdd:pfam00400 2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
273-430 |
7.60e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 43.00 E-value: 7.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 273 TPTPRSDMPTPGTSATPGLRPGLGKPPA--IDPLVNQAAAGLRTPLAV--PGPYPAPFG-------MVPHAGMNGELTSP 341
Cdd:PHA03247 2707 TPEPAPHALVSATPLPPGPAAARQASPAlpAAPAPPAVPAGPATPGGParPARPPTTAGppapappAAPAAGPPRRLTRP 2786
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 342 GAAYASLHNMSPQMSAAAAAAAVVAYGRSPMV-------GFDPPPHMRVPTIPPNLAGIPGGKPAYSFHVTADGQMQPVP 414
Cdd:PHA03247 2787 AVASLSESRESLPSPWDPADPPAAVLAPAAALppaaspaGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRP 2866
|
170
....*....|....*.
gi 1034671132 415 FPPDALIGPGIPRHAR 430
Cdd:PHA03247 2867 PSRSPAAKPAAPARPP 2882
|
|
| NBCH_WD40 |
pfam20426 |
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ... |
522-603 |
9.55e-04 |
|
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.
Pssm-ID: 466575 [Multi-domain] Cd Length: 350 Bit Score: 41.98 E-value: 9.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 522 AELTSSAPACYALAISPDSKVCFSCcsdGNiavWD-------LHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTV 594
Cdd:pfam20426 75 AENVELGAQCFATLQTPSENFLISC---GN---WEnsfqvisLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTV 148
|
....*....
gi 1034671132 595 RSWDLREGR 603
Cdd:pfam20426 149 MVWEVLRGR 157
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
517-556 |
9.94e-04 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 37.29 E-value: 9.94e-04
10 20 30 40
....*....|....*....|....*....|....*....|
gi 1034671132 517 TPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWD 556
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
146-417 |
3.18e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 40.91 E-value: 3.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 146 RDREPGTSNSllvPDSLRGTDKRRNGPEFSndikkRKVDDKDSSHYDSDGDKSDDNLVVDVSNEDPSSPRASPA-HSPRE 224
Cdd:pfam03154 82 RQREKGASDT---EEPERATAKKSKTQEIS-----RPNSPSEGEGESSDGRSVNDEGSSDPKDIDQDNRSTSPSiPSPQD 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 225 NGIDKNRLLKKDAssspastassasstsLKSKEMSLHEKASTPVLKSSTPTPRSDMPTPG-TSATPGLRPGLGKPPAIDP 303
Cdd:pfam03154 154 NESDSDSSAQQQI---------------LQTQPPVLQAQSGAASPPSPPPPGTTQAATAGpTPSAPSVPPQGSPATSQPP 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 304 LVNQAAAGLRT---------PLAVPGPYPAPFGMVPHAGMNGELTSPGAAyASLHNMSPQMSAAAAAAAVVAYGRSPMVG 374
Cdd:pfam03154 219 NQTQSTAAPHTliqqtptlhPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQ-PSLHGQMPPMPHSLQTGPSHMQHPVPPQP 297
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 1034671132 375 FDPPPHMRVPTIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPP 417
Cdd:pfam03154 298 FPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPP 340
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
283-421 |
4.32e-03 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 40.44 E-value: 4.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034671132 283 PGTSATPGLRPGLGKPPAIDPLVNQAAAGLRTPLavPGPYPAPFGMVPHAGMNGELTSPGAAYASLHnmSPQMSAAAAAA 362
Cdd:PHA03378 691 PGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRA--RPPAAAPGRARPPAAAPGRARPPAAAPGRAR--PPAAAPGRARP 766
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1034671132 363 AVVAYGRspmvgfdpPPHMRVPTIPPNLAGIPGGKPAysfhvtadgQMQPVPFPPDALI 421
Cdd:PHA03378 767 PAAAPGA--------PTPQPPPQAPPAPQQRPRGAPT---------PQPPPQAGPTSMQ 808
|
|
|