|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
12-482 |
0e+00 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 589.86 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 12 GWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAG 91
Cdd:cd17428 1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 92 GLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCL 171
Cdd:cd17428 81 GLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 172 LIVGALALNILACGSLMRplqssdcplpkkiapedlpdkysiynekgknleeninildksysseekcritlangdwkqds 251
Cdd:cd17428 161 LIVGALALNLLACGSLMR-------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 252 llhknptvthtkepetykkkvaeqtyfckqlakrkwqlyknycgetvaLFKNKVFSALFIAILLFDIGGFPPSLLMEDVA 331
Cdd:cd17428 179 ------------------------------------------------LFKNRVFSALFIAILLFDIGAFPPSLLMEDVA 210
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 332 RSSNVKEEEFIMPLISIIGIMTAVGKLLLGILADFKWINTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGILGFLTGN 411
Cdd:cd17428 211 RSENIIEEIALIPLVSIIGITTAIGKLILGVLADFKWVNSLYLYVLTLIGMGAALLAIPFAKSYLTLAVLSAILGFLSGN 290
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034567082 412 WSIFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLAA 482
Cdd:cd17428 291 WSIFPYVTTKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFLLLLAA 361
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
12-481 |
5.27e-128 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 377.91 E-value: 5.27e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 12 GWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAG 91
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 92 GLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCL 171
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 172 LIVGALALNILACGSLMRPLQSSDCPLPKkiapedlpdkysiynekgknleeninildksysseekcritlangdwkqds 251
Cdd:cd17314 161 TILGILAAIVLSVVSLLGFKEPPDNQARL--------------------------------------------------- 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 252 llhknptvthtkepetykkkvaeqtyfckqlakrkwQLYKNYCGETVALFKNKVFSALFIAILLFDIGGFPPSLLMEDVA 331
Cdd:cd17314 190 ------------------------------------HVQKKKTQTMGEIFRDKVFWILFIAIFLVLIGGFLFIANMASLV 233
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 332 RSSNVKEEEFIMPLISIIGIMTAVGKLLLGILADFKwINTLYLYVATLIIMGLALCAIPFAKSY--VTLALLSGILGFLT 409
Cdd:cd17314 234 RSLQLDAPSFVTKLMSIYGLFNAFGRLLWGIVADFF-GGRLSTLSILLTILGLGLCAFLFLLKMtpVGLVLTGSLLGFSY 312
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034567082 410 GNWSIFPYVTTKTV-GIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLA 481
Cdd:cd17314 313 GGLFTVYPATVSTVfGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAILLAV 385
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
12-481 |
5.34e-104 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 315.65 E-value: 5.34e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 12 GWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAG 91
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 92 GLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCL 171
Cdd:cd17352 81 GLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 172 LIVGALALNILACGSLMRplqssdcplpkkiapedlpdkysiynekgknleeninildksysseekcritlangdwkqds 251
Cdd:cd17352 161 LILGGLCLNLCVCGLLLR-------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 252 llhknptvthtkepetykkkvaeqtyfckqlakrkwqlyknycgetvaLFKNKVFSALFIAILLFDIGGFPPSLLMEDVA 331
Cdd:cd17352 179 ------------------------------------------------LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYA 210
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 332 RSSNVkEEEFIMPLISIIGIMTAVGKLLLGILADFKWINTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGILGFLTGN 411
Cdd:cd17352 211 KSLGI-DESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGS 289
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034567082 412 WSIFPYVT-TKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLA 481
Cdd:cd17352 290 YSSLTPVIlADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLL 360
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
12-480 |
3.43e-65 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 215.08 E-value: 3.43e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 12 GWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAG 91
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 92 GLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCL 171
Cdd:cd17429 81 GWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 172 LIVGALALNILACGSLMRplqssdcplpkkiapedlpdkysiynekgknleeninildksysseekcritlangdwkqds 251
Cdd:cd17429 161 FIQGAVSLNLCVCGALMR-------------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 252 llhknptvthtkepetykkkvaeqtyfckqlakrkwqlyknycgetvaLFKNKVFSALFIAILLFDIGGFPPSLLMEDVA 331
Cdd:cd17429 179 ------------------------------------------------LFTNKVFVAFIFWALFAYCSFVIPFIHLPEIV 210
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 332 RSSNVKEEEFIMPLISIIGIMTAVGKLLLGILADFKWINTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGILGFLTGN 411
Cdd:cd17429 211 KLYGLSEQNDKFPLTSIIAIVHIFGKVILGIICDLPCISVWNVFILANFTLGVCILILPLMHTYTGLAIVCALIGFSSGY 290
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034567082 412 WSIFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLL 480
Cdd:cd17429 291 FSLMPVVTEDLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYVCGLLYMVGIICLLL 359
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
7-481 |
3.72e-55 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 191.49 E-value: 3.72e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 7 PDGGWGWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSG 86
Cdd:TIGR00892 12 PDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAGG 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 87 FMVAGGLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYG 166
Cdd:TIGR00892 92 LLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFESFG 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 167 LDGCLLIVGALALNILACGSLMRPLQSSDCPLPKKiapedlpdkysiynekgknleeninildksysseekcritlangd 246
Cdd:TIGR00892 172 WRGSFLILGGLLLHCCVCGALMRPVGPSQRVSKSK--------------------------------------------- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 247 wkqdsllhknptvthTKEpetykkkvaeqtyfCKQLAKRKWQLYKNYCGETV------ALFKNKVFSALFIAILLFDIGG 320
Cdd:TIGR00892 207 ---------------SKE--------------GLPPDGSTKKLSKKSTAEKInrfldfSLFTHRGFLVYLSGNVIMFLGF 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 321 FPPSLLMEDVARSSNVKEEEFIMpLISIIGIMTAVGKLLLGILADFKWINTLYLYVATLIIMGLALCAI--PFAKSYVTL 398
Cdd:TIGR00892 258 FAPIIFLVPYAKDKGVDEYEAAF-LLSIIGFVDIFARPSCGLIAGLKWIRPHVQYLFSFALLFNGLTHLlcALAGDYTGL 336
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 399 ALLSGILGFLTGNWSIFPY-VTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFI 477
Cdd:TIGR00892 337 VIYCIFFGLSFGSVGALLFeVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYASGSIVVSAGLF 416
|
....
gi 1034567082 478 LLLA 481
Cdd:TIGR00892 417 LAIG 420
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
12-484 |
2.63e-54 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 187.21 E-value: 2.63e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 12 GWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAG 91
Cdd:cd17423 1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 92 GLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCL 171
Cdd:cd17423 81 GFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 172 LIVGALALNILACGSLMRPLqssdcplpkkIAPEDLPDKYSIYnekgknleeninildksysseekcritlangdwkqds 251
Cdd:cd17423 161 LLLSALSLHLVPCGALLRPL----------ALPGDPPAPPRSL------------------------------------- 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 252 llhknptvthtkepetykkkvaeqtYFCKQLakrkwqlyknycgetvALFKNKVFSALFIAILLFDIGGFPPSLLMEDVA 331
Cdd:cd17423 194 -------------------------SAAFGL----------------SLLTHRAFLRYALATTLINTGYFIPYVHLVAHA 232
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 332 RSSNVKEEEFIMpLISIIGIMTAVGKLLLGILADFKWINTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGILGFLTGN 411
Cdd:cd17423 233 RALGLGEYQAAF-VVSVAAVADAVGRLFSGWLADLGPLRLLHLLVLWTALTGLSLLLLPLAKVYGSLLALAVAYGFCAGA 311
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034567082 412 WS-IFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLlaALP 484
Cdd:cd17423 312 LApLVFSVLPELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLLLGSLILL--TLP 383
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
12-480 |
1.21e-45 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 163.38 E-value: 1.21e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 12 GWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAG 91
Cdd:cd17422 1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 92 GLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCL 171
Cdd:cd17422 81 GMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 172 LIVGALALNILACGSLMRPLQssdcplpkkiapedlpdkysiynekgknleeninildksysseekcritlangdwkqds 251
Cdd:cd17422 161 LVVGALQLNIVVCGALLRVLK----------------------------------------------------------- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 252 llhknptvthtkepetykkkvaEQTYFCkqlakrkwqlyknycgetVALFknkvfsALFIAillfdIGGFPPSLLMEDVA 331
Cdd:cd17422 182 ----------------------EPGFIC------------------YALF------GLFAT-----LGFFAPQLYIIPLS 210
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 332 RSSNVkEEEFIMPLISIIGIMTAVGKLLLGILADFKWINTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGILGFLTGN 411
Cdd:cd17422 211 LSLGI-DQDWAAYMLSAMAIAELFGRISAGWVLNKCPIRKIYIELICVILLCVVLLLFPFAYGFWSLLVCSIFYGFMFGT 289
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034567082 412 WS---IFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLL 480
Cdd:cd17422 290 VAgthIPLLAEDDVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGAVFLAL 361
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
12-480 |
2.47e-41 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 152.68 E-value: 2.47e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 12 GWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFG-----EGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSG 86
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLTklgdpEASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 87 FMVAGGLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYG 166
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 167 LDGCLLIVGALALNILACGSLMRPLQSSdcplpkkiaPEDLPDKYSiynekGKNLEENINILDKSYSSeekcritlangd 246
Cdd:cd17420 161 LEGTLRVLSLFMFVLILCSFTYRPLHPS---------PEDPKSKPG-----RRTLHSRINLFLRKIFN------------ 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 247 wkqdsllhknptvthtkepetykkkvaeqtyfckqlakrkwqlyknycgetVALFKNKVFSALFIAILLFDIGGFPPSLL 326
Cdd:cd17420 215 ---------------------------------------------------VEIFKRKRYVIWALGIPLALFGYFVPYVH 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 327 MEDVARSSNVKEEEFIMPLISiIGIMTAVGKLLLGILADF-KWINTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGIL 405
Cdd:cd17420 244 LMKFVKEEFFPGKDVNVPLMC-IGITSGIGRLIFGVIADMpPGVKKMYLQVLSFVSIGLMSMMIPLCNSFGILISVCLVM 322
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034567082 406 GFLTGNW-SIFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLL 480
Cdd:cd17420 323 GLFDGCFiSIMAPIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLAGVPPLIGSSLLFF 398
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
12-483 |
3.79e-38 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 143.42 E-value: 3.79e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 12 GWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAG 91
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 92 GLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGssVGL-FIYAALQRMLVEFYGLDGC 170
Cdd:cd17421 81 GFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSG--MGLtFALAPFTQLLLDEYDWQGA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 171 LLIVGALALNILACGSLMRPLQSSdcplpkkiapedlpdkysiynekgknleeninildksysseekcritlangdwkqd 250
Cdd:cd17421 159 LLIFGGIMLNLVASGMLLRPIDFS-------------------------------------------------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 251 slLHKNPtvthtkepetykkkvaeqtYFCKQlakrKWQLyknycgetvalfknkVFSALFIAILLFDIGGFPPSLLMEDV 330
Cdd:cd17421 183 --LLKDP-------------------FFCIY----TWSF---------------VFSQLAYFIPYFHLVARARTLGIDPM 222
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 331 ARSSnvkeeefimpLISIIGIMTAVGKLLLGILADFKWINTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGILGFLTG 410
Cdd:cd17421 223 DASF----------IISVAGITETVAQLASGWIADQNWIKKYHYHKAYLILCGVTNLLAPLATTYPLLMTYAVFFAIFCG 292
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034567082 411 NW-SIFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLAAL 483
Cdd:cd17421 293 GYlALLLPVLVDLVGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGGCYLLSSVSFFLEPL 366
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
12-481 |
1.03e-37 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 142.17 E-value: 1.03e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 12 GWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAG 91
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLASL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 92 GLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCL 171
Cdd:cd17430 81 GMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 172 LIVGALALNILACGSLMRPLQssdcplpkkiapedlpdkysiynekgknleeninildksysseekcritlangdwkqds 251
Cdd:cd17430 161 LILGGLLLNCCTCGAVMRPLD----------------------------------------------------------- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 252 llhknptvthtkepetykkkvaeqtyfckqlakrkwqlyknycgetVALFKNKVFSALFIAILLFDIGGFPPSLLMEDVA 331
Cdd:cd17430 182 ----------------------------------------------FSVFRDRGFVIYTIAKFIMVLGLFVPPIFVVNYA 215
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 332 RSSNVKEEEFIMpLISIIGIMTAVGKLLLGILADFKWI--NTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGILGFLT 409
Cdd:cd17430 216 KDIGVPDTEAAF-LLSILGFIDIFARPACGVVAGLKWVrpRVVYLFSFAMLFNGLTDLCSATAADYGGLVVFCVFFGISY 294
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034567082 410 GNWSIFPY-VTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLA 481
Cdd:cd17430 295 GMVGALQFeVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVLSALFLALG 367
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
12-482 |
4.49e-34 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 131.86 E-value: 4.49e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 12 GWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAG 91
Cdd:cd17424 1 GWMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLAST 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 92 GLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCL 171
Cdd:cd17424 81 GLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 172 LIVGALALNILACGSLMRPLQSSDcplpkkiapedlpdkysiynekgknleeninildksysseekcritlangdwkqds 251
Cdd:cd17424 161 LILGGFVLNLCVCGALMRFLLMPD-------------------------------------------------------- 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 252 llhknptvthtkepetykkkvaeqtyfckqlakrkwqlyknycgetvalfknkvFSALFIAILLFDIGGFPPSLLMEDVA 331
Cdd:cd17424 185 ------------------------------------------------------FLVLAVSVLFLAYGCSPPFVYLVPYA 210
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 332 RSSNVKEEEFIMpLISIIGIMTAVGKLLLGILADFKWINTlYLYVATLIIMGL-ALCA--IPFAKSYVTLALLSGILGFL 408
Cdd:cd17424 211 LSVGVSHQQAAF-LMSILGVIDIIGNITFGWLTDRRCLKK-YRYFCYLFAVGMdGLCClfLPILKTFPLLVPFSFTFGYF 288
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034567082 409 TGNW-SIFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLAA 482
Cdd:cd17424 289 DGAYvALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIFSSLLLGSAR 363
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
12-478 |
1.13e-28 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 117.20 E-value: 1.13e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 12 GWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFG-----EGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSG 86
Cdd:cd17464 1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFGskddaQMRFKTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 87 FMVAGGLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYG 166
Cdd:cd17464 81 AVGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 167 LDGCLLIVGALALNILACGSLMRPLqssdcpLPKKIAPEDLPDKYsiynekgknleeninildksysseekcritlangd 246
Cdd:cd17464 161 LFNTLRVLCIFMFVLFLAGFTYKPL------VPMKKDKEGKKRKF----------------------------------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 247 wkqdsllhKNPTVthtkepetykKKVAEQTYFcKQLAKRKWQLyknycGETVALFknkvfsalfiaillfdiGGFPPSL- 325
Cdd:cd17464 200 --------KCPPL----------KKIFNFNIW-KSTGYRIWAF-----GIPAALF-----------------GYFVPYVh 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 326 LMEDVARS--SNVKEEEFIMplisIIGIMTAVGKLLLGILADF-KWINTLYLYVATLIIMGLALCAIPFAKSYVTLALLS 402
Cdd:cd17464 239 LMNHVKERfgEDVNKEVLLM----CIGITSGIGRLIFGRVADYiPGVKKVYLQVSSFFFIGLMSMMIPLCHVFGGLIAVC 314
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034567082 403 GILGFLTGNW-SIFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFIL 478
Cdd:cd17464 315 LFMGLFDGCFiSIMAPIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAFYLAGVPPIIGGIIL 391
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
12-481 |
1.41e-28 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 116.41 E-value: 1.41e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 12 GWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAG 91
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 92 GLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCL 171
Cdd:cd17425 81 GMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 172 LIVGALALNILACGSLMRPlqssdcplpkkiapedlpdkysiynekgknleeninildksysseekcritlangdwkqds 251
Cdd:cd17425 161 LVFGGVLLNCCVCGAVMRP------------------------------------------------------------- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 252 llhknptvthtkepetykkkvaeqtyfckqlakrkwqlyknycgetvaLFKNKVFSALFIAILLFDIGGFPPSLLMEDVA 331
Cdd:cd17425 180 ------------------------------------------------FCSNTRYQIYTLGVTWMVLGFVLPLIYLVPYA 211
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 332 RSSNVKEEEFIMpLISIIGIMTAVGKLLLGILADFKWIN--TLYLYVATLIIMGLA--LCAIPFA-KSYVTLALLSGILg 406
Cdd:cd17425 212 TSNGMDESKAAL-LLSILGFINIFMRPLAGLLSGLPVFKgrRIYLFSLALLLNGLSnlICAISASfPVLLVYCLLYSIS- 289
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034567082 407 fLTGNWSIFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLA 481
Cdd:cd17425 290 -MSGIGSLIFQVLMDTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVFYASSIFVVSAALFMGLS 363
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
16-479 |
5.03e-28 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 115.22 E-value: 5.03e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 16 VFVSFLTQFLCYGSplaVGVLYIEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAGGLML 95
Cdd:cd06174 1 LLLGFFLTGLARGL---ISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 96 SSFAPNIYFLFFSYgIVVGLGCGLLYTATVTITCQYFDDR-RGLALGLISTGSSVGLFIYAALQRMLVEF--YGLDGCLL 172
Cdd:cd06174 78 FAFAPSFWLLLLGR-FLLGLGSGLIDPAVLALIADLFPEReRGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 173 IVGALALNILACGSLMRPLQSSdcplpkkiapedlpdkysiynekgknleeninildksysseekcritlangdwkqdsl 252
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPE---------------------------------------------------------- 178
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 253 lhknptvthtkepetykkkvaeqtyfcKQLAKRKWQLYKNYCGETVALFKNKVFSALFIAILLFDIGGFPPSLLMEDVAR 332
Cdd:cd06174 179 ---------------------------SARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLL 231
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 333 SSNVKEEEFIMPLISIIGIMTAVGKLLLGILADfKWINTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGILGFLTGNW 412
Cdd:cd06174 232 DLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSD-RLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGL 310
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034567082 413 SIFPYV-TTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILL 479
Cdd:cd06174 311 LPLSFAlIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
12-480 |
4.13e-26 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 109.58 E-value: 4.13e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 12 GWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAG 91
Cdd:cd17426 1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 92 GLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCL 171
Cdd:cd17426 81 GLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 172 LIVGALALNILACGSLMRPlqssdcplpkkIAPEDLPDkysiynekgknleeninildksysseekcritlangdwkqds 251
Cdd:cd17426 161 LILGGLLLNCCVAGSLMRP-----------IGPKPFLD------------------------------------------ 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 252 llhknptvthtkepetykkkvaeqtyfckqlakrkwqlyknycgetVALFKNKVFSALFIAILLFDIGGFPPSLLMEDVA 331
Cdd:cd17426 188 ----------------------------------------------LTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSNYA 221
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 332 RSSNVKEEEFIMpLISIIGIMTAVGKLLLGILADFKWI--NTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGILGFLT 409
Cdd:cd17426 222 KSKQISNESAAF-LLSILAFVDMVARPSMGIVANTKWVrpRIQYFFAASVLYNGVCHLLAPLSTSYVGFCIYAIFFGFAF 300
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034567082 410 GNWSIFPYVT-TKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLL 480
Cdd:cd17426 301 GWLSSVLFETlMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWACGIVLIISSIYLFI 372
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
13-480 |
3.27e-25 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 107.31 E-value: 3.27e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 13 WVIVFVSFLTQFlCYGSPLAVGVLYIEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAGG 92
Cdd:cd17353 3 WLVLLGAVLMHL-ILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 93 LMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCLL 172
Cdd:cd17353 82 FILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 173 IVGALALNILACGSLMrplqssdcplpkkiapedlpdkysiynekgknleeninildksysseekcrITLANGDWKQDSL 252
Cdd:cd17353 162 ILGIIFLIIIVIGAFL---------------------------------------------------IRDPPKGWVPPGV 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 253 LHKNPTVTHTKEPETYKKkvaeqtyfckqlakrkwqlyknycgetvaLFKNKVFSALFIAILLFDIGGFPPSLLMEDVAR 332
Cdd:cd17353 191 DPLANNAENSPRDYTPRE-----------------------------MLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQ 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 333 SSNVKEEEFIMPLISIIGIMTAVGKLLLGILADFkwINTLYLYVATLIIMGLALCAIPFAKS-YVTLALLSGILGF-LTG 410
Cdd:cd17353 242 EFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDK--IGRKNTLSIAFLIQGVAMFLLPFIGSvAVLFVLGVALIGFcYGG 319
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 411 NWSIFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGwFYDWTQTYDIAFYFSGFCVLLGGFILLL 480
Cdd:cd17353 320 GFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAA-YVLYTGGYNAAFIIAAALSLVALALALL 388
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
12-480 |
1.39e-24 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 104.89 E-value: 1.39e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 12 GWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAG 91
Cdd:cd17427 1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 92 GLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCL 171
Cdd:cd17427 81 GMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 172 LIVGALALNILACGSLMRPLqssdcplpkkiapedlpdkysiynekgknleeninildksysseekcritlangdwkqds 251
Cdd:cd17427 161 LILGGLLLNCCVAGSLMRPL------------------------------------------------------------ 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 252 llhknptvthtkepetykkkvaeqtyfckqlakrkwqlyknycgetVALFKNKVFSALFIAILLFDIGGFPPSLLMEDVA 331
Cdd:cd17427 181 ----------------------------------------------GPLFKHRGFLIYLSGNVIMFLGFFAPIVFLAPYA 214
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 332 RSSNVKEEEFIMpLISIIGIMTAVGKLLLGILADFKWINTLYLYVATLIIMGLALCAI--PFAKSYVTLALLSGILGFLT 409
Cdd:cd17427 215 KHMGIDEYSAAF-LLSILAFVDMFARPSMGLVANSKWIRPRIQYFFSFAVMYNGVCHLlcPLAEDYTGLVIYAVFFGFAF 293
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034567082 410 GNWSIFPYVT-TKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLL 480
Cdd:cd17427 294 GMVSSVLFETlMDLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIVASIWLFI 365
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
12-479 |
1.08e-23 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 102.73 E-value: 1.08e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 12 GWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAG 91
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 92 GLMLSSFAPNIYFLFFSYGIVVGLGCGLLY-TATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGC 170
Cdd:cd17355 81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAaVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 171 LLIVGALALNILACGSLMRPlqssdcPLPKKIAPEDlpdkysiynekgknleeninildksysseekcritlangdwkqd 250
Cdd:cd17355 161 LLVLALLALLVLVPVLLLLR------RRPADLALRA-------------------------------------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 251 sllhknPTVTHTKEPETYKKKVAEQTYFckqlakrkWQLYKNY--CGETValfknkVFSALFIAILLFDIgGFPPSLLME 328
Cdd:cd17355 191 ------YDDASPASPGSTLKEALRSASF--------WLLALAFflCGFAV------VGLIVHLVPYLADR-GISPAAAAV 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 329 dvarssnvkeeefimpLISIIGIMTAVGKLLLGILADFkwINTLYLYVATLIIMGLALCAIPFA-KSYVTLALLSGILGF 407
Cdd:cd17355 250 ----------------ALALIGLFNIVGRLLSGWLGDR--YSPRRLLAASYALRALGLALLLLLpFPPLALLLFAALFGL 311
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034567082 408 LTGNWSIFPYVTTKTV-GIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILL 479
Cdd:cd17355 312 GWGATVPLTAALAARYfGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVL 384
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
13-480 |
4.15e-22 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 98.03 E-value: 4.15e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 13 WVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAGG 92
Cdd:COG2223 4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 93 LMLSSFAPNiYFLFFSYGIVVGLGCGLLYTATVTITCQYF-DDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCL 171
Cdd:COG2223 84 LLLLALAVS-YWLLLLLGLLLGIGGGGSFAVGIALVSKWFpPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 172 LIVGALALNILACGSLMrplqssdcplpkkiapedlpdkysiynekgknleeninildksysseekcritlangdwkqds 251
Cdd:COG2223 163 LILGILLLVVAVLAWLF--------------------------------------------------------------- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 252 llhknptvthTKEPETYKKKVAEQTyfckqlakrkwqlyknyCGETVALFKNKVFSALFIAILLFDIGGFPPSLLMEDVA 331
Cdd:COG2223 180 ----------LRDPPAGAAAAAKAS-----------------LRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYL 232
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 332 RSSNVKEEEFIMPLISIIGIMTAVGKLLLGILADfkWINTLYLYVATLIIMGLALCAIPFA-KSYVTLALLSGILGFLTG 410
Cdd:COG2223 233 VDQFGLSAATAGLLAALFALLGALGRPLGGWLSD--RIGGRRVLLIVFALMALGLLLLALAlGSLWLFLVLFLLLGLALG 310
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034567082 411 NWS-IFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLL 480
Cdd:COG2223 311 GGNgAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLL 381
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
12-479 |
8.37e-19 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 87.93 E-value: 8.37e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 12 GWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFGEGKG-----KTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSG 86
Cdd:cd17465 1 GWVVVFAATWCNGSIFGIQNSFGILYVMLLNEQEDQKDqavqfKTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 87 FMVAGGLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYG 166
Cdd:cd17465 81 AVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGDAIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 167 LDGCLLIVGALALnILACGSLmrplqssdcplpkkiapedlpdkysiynekgknleeninildksysseekcritlangd 246
Cdd:cd17465 161 LAHTFQVLSLFMF-IQIFLSL----------------------------------------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 247 wkqdsllhknptvthtkepeTYKkkvaeqtyfckqlakrkwqlyknycgetvaLFKNKVFSALFIAILLFDIGGFPPSL- 325
Cdd:cd17465 181 --------------------TYK------------------------------VFRRKTYRIWAFGIATAVLGYFVPYVh 210
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 326 LMEDVARSSNVKEEEFIMPLisIIGIMTAVGKLLLGILAD-FKWINTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGI 404
Cdd:cd17465 211 LMKYVEEEFKENKREWVLLV--CIGASSGIGRLMSGKIGDlIPGLKKIYLQVASFLLLGIMSMMIPLCQVFEGVIVVCLF 288
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034567082 405 LGFLTGNW-SIFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILL 479
Cdd:cd17465 289 LGLCDGCFiTIMAPIAFELVGPMQASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSYHVAFYLAGVPPIIGGTVLF 364
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
5-482 |
1.57e-18 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 87.23 E-value: 1.57e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 5 KSPDGGWGWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIF 84
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 85 SGFMVAGGLMLSSFAPNIYFLFFSYgIVVGLGCGLLYTATVTITCQYF-DDRRGLALGLISTGSSVGLFIYAALQRMLVE 163
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLR-FLLGLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 164 FYGLDGCLLIVGALALNILACGSLMrplqssdcplpkkiapedlpdkysiynekgknleeninildksysseekcrITLA 243
Cdd:COG2271 160 AFGWRAAFLILGLPGLLLALLRFWL---------------------------------------------------LALA 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 244 ngdwkqdsllhknptvthtkepetykkkvaeqtYFCkqlakrkwqlykNYCGETVALFknkvfsalFIAILLFDIGGFPP 323
Cdd:COG2271 189 ---------------------------------YFL------------VYFALYGFLT--------WLPTYLVEVRGLSL 215
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 324 SLlmedvarssnvkeeefIMPLISIIGIMTAVGKLLLGILADFKWINTLYLYVATLIIMGLALCAIPFAKSYVTLALLSG 403
Cdd:COG2271 216 AQ----------------AGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLF 279
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 404 ILGFLT-GNWSIFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQtYDIAFYFSGFCVLLGGFILLLAA 482
Cdd:COG2271 280 LAGFGLgGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLLAALALLAALLALLLL 358
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
6-445 |
7.95e-15 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 75.78 E-value: 7.95e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 6 SPDGGWGWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFS 85
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 86 GFMVAGGLMLSSFAPNIYFLFFSyGIVVGLGCGLLYTATVTITCQYFD-DRRGLALGLISTGSSVGLFIYAALQRMLVEF 164
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAA-RFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 165 YGLDGCLLIVGALALniLACGSLMRPLqssdcplpkkiapedlpdkysiynekgknleeninildksysseekcritlan 244
Cdd:COG2814 161 FGWRWVFLVNAVLAL--LALLLLLRLL----------------------------------------------------- 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 245 gdwkqdsllhknptvthtkePETYKKKVAEQTyfckqlakrkwqlyknycGETVALFKNKVFSALFIAILLFDIGGFPPS 324
Cdd:COG2814 186 --------------------PESRPAARARLR------------------GSLRELLRRPRLLLLLLLAFLLGFGFFALF 227
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 325 LLMEDVARSSNVKEEEFIMPLISIIGIMTAVGKLLLGILADfkWINTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGI 404
Cdd:COG2814 228 TYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD--RFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFL 305
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 1034567082 405 LGFltGNWSIFPYVTT---KTVGIEKLAHAYGILMFFAGLGNSL 445
Cdd:COG2814 306 LGF--GFGLLFPLLQAlvaELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
11-488 |
1.15e-13 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 72.60 E-value: 1.15e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 11 WGWVIVFVSFLTQFLCYGSPL-AVGVLYIEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMV 89
Cdd:COG2807 14 AGRWLLLLAIVLVALNLRPAItSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 90 AGGLMLSSFAPNIYFLFFSYgIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDG 169
Cdd:COG2807 94 AAGLLLRSLAPSVALLLAGT-ALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRG 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 170 CLLIVGALALNILACGSLMRPLQSSDCPLPKKIAPEdlpdkysiynekgknleeninildksysseekcritlangdwkq 249
Cdd:COG2807 173 ALAVWALLALLALLLWLPLLRRRPAAAAAAPAAASL-------------------------------------------- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 250 dSLLHKNPTVthtkepetykkkvaeqtyfckqlakrkWQLyknycgeTVALFknkVFSALFIAILlfdigGFPPSLLME- 328
Cdd:COG2807 209 -RSLWRSPLA---------------------------WLL-------TLFFG---LQSLLYYAVV-----AWLPPILRDa 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 329 --DVARSSNvkeeefimpLISIIGIMTAVGKLLLGILADfKWINTLYLYVATLIIMGLALCAIPFAKSYVTLaLLSGILG 406
Cdd:COG2807 246 glSAATAGL---------LLSLFQLAGIPGSLLVPLLAD-RLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPW-LWAVLLG 314
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 407 FLTGnwSIFP----YVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLAA 482
Cdd:COG2807 315 LGQG--GLFPlaltLIGLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLAG 392
|
....*.
gi 1034567082 483 LPSWDT 488
Cdd:COG2807 393 RPYVED 398
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
20-447 |
7.37e-13 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 69.75 E-value: 7.37e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 20 FLTQFLCYGSPLAVGVLYIEWL-DAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAGGLMLSSF 98
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLaEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 99 APNIYFLFFSyGIVVGLGCGLLYTATVTITCQYF-DDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCLLIVGAL 177
Cdd:pfam07690 82 ASSLWLLLVL-RVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 178 ALNILACGSLMRPlqssdcplpkkiapedlpdkysiynekgknleeninildksysseekcritlangdwkqdsllhknp 257
Cdd:pfam07690 161 SLLAAVLLLLPRP------------------------------------------------------------------- 173
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 258 tvthtkEPETYKKKVAEQTYFCKQLAKRkwqlyknycgetvALFKNKVFSaLFIAILLFDIGGFPPSLLMEDVARSSNVK 337
Cdd:pfam07690 174 ------PPESKRPKPAEEARLSLIVAWK-------------ALLRDPVLW-LLLALLLFGFAFFGLLTYLPLYQEVLGLS 233
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 338 EEEFIMpLISIIGIMTAVGKLLLGILAD-FKWINTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGILGFLTG-NWSIF 415
Cdd:pfam07690 234 ALLAGL-LLGLGGLLGAIGRLLLGRLSDrLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGlVFPAL 312
|
410 420 430
....*....|....*....|....*....|..
gi 1034567082 416 PYVTTKTVGIEKLAHAYGILMFFAGLGNSLGP 447
Cdd:pfam07690 313 NALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
16-480 |
2.03e-11 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 65.68 E-value: 2.03e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 16 VFVSFLTQFLCYGSPLAVGVLYIEwldAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAGGLML 95
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAE---SLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 96 SSFAPNIYFLFFSYgIVVGLGCGLLYTATVTITCQYF-DDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCLLIV 174
Cdd:cd17325 78 FAFATSYWQLLLAR-FLQGLASAAVWPAAMALIADIApPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 175 GALALNILACGSLMRPlqssdcplpkkiapEDLPDKYSIYNEKGKNLEENINILdksysseekcritlangdwkqdsllh 254
Cdd:cd17325 157 AALALLALVLALLLLP--------------EPRPPPNKRAVSAARLRSGLRLLL-------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 255 knptvthtkepetykkkvaeqtyfckqlakRKWQLYKNYCGETVALFknkVFSAL--FIAILLFDIGGFPPSLlmedvar 332
Cdd:cd17325 197 ------------------------------RDRRLLALFLAIFVLAF---AFGALepFLPLYAAELGGLSPAQ------- 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 333 ssnvkeeefIMPLISIIGIMTAVGKLLLGILADfkWINTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGILGFLTG-- 410
Cdd:cd17325 237 ---------IGLLFGAQGLASALSQPPAGKLSD--RIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGlv 305
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 411 NWSIFPYVtTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDwTQTYDIAFYFSGFCVLLGGFILLL 480
Cdd:cd17325 306 FPATLALL-ADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD-AFGFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
345-480 |
4.97e-10 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 61.05 E-value: 4.97e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 345 LISIIGIMTAVGKLLLGILAD-FKWINTLYLYVATLIIMGLALCAIPFAKS-YVTLALLSGILGFLTGNWSIFPYVTTKT 422
Cdd:cd17319 220 LAAIPFLAGAIGMILGGRLSDrLLRGARRLVIIIGLLLAAVGLLLAYLTTSpVVAVILLSLAGFGIGAASPVFWSLPADL 299
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1034567082 423 VGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLL 480
Cdd:cd17319 300 LPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
297-484 |
1.27e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 59.60 E-value: 1.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 297 TVALFKNKVFSALFIAILLFDIGGFPPSLLMEDVARSSNVKEEEFIMpLISIIGIMTAVGKLLLGILADfkWINTLYLYV 376
Cdd:COG2814 3 ATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGL-VVTAYLLGAALGAPLAGRLAD--RFGRRRVLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 377 ATLIIMGLALCAIPFAKSYVTLALLSGILGFLTG-NWSIFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYD 455
Cdd:COG2814 80 LGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGaLFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159
|
170 180
....*....|....*....|....*....
gi 1034567082 456 WTqTYDIAFYFSGFCVLLgGFILLLAALP 484
Cdd:COG2814 160 LF-GWRWVFLVNAVLALL-ALLLLLRLLP 186
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
304-483 |
2.87e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 58.73 E-value: 2.87e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 304 KVFSALFIAILLFDIGGFPPSLLMEDVARSSNVKEEEFIMpLISIIGIMTAVGKLLLGILADfkWINTLYLYVATLIIMG 383
Cdd:COG2271 10 RILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGL-LASAFFLGYALGQIPAGLLAD--RFGRRRVLAIGLLLWG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 384 LALCAIPFAKSYVTLALLSGILGFLTG-NWSIFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWF---YDWTQT 459
Cdd:COG2271 87 LATLLFGFATSFWQLLLLRFLLGLGEAgFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLlaaFGWRAA 166
|
170 180
....*....|....*....|....
gi 1034567082 460 YdiaFYFSGFCVLLGGFILLLAAL 483
Cdd:COG2271 167 F---LILGLPGLLLALLRFWLLAL 187
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
306-502 |
5.35e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 57.81 E-value: 5.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 306 FSALFIAILLFDIGGFPPSLLMEDVARSSNVkeeefIMPLISIIGIMTAVGKLLLGILADFkwINTLYLYVATLIIMGLA 385
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAEDLGISPTE-----IGLLLTLFSLGYALAQPLAGRLSDR--FGRRRVLLIGLLLFALG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 386 LCAIPFAKSYVTLALLSGILGFLTG-NWSIFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTqTYDIAF 464
Cdd:pfam07690 76 LLLLLFASSLWLLLVLRVLQGLGAGaLFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF-GWRAAF 154
|
170 180 190
....*....|....*....|....*....|....*...
gi 1034567082 465 YFSGFCVLLGGFILLLAALPSWDTCNKQLPKPAPTTFL 502
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIV 192
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
13-190 |
6.35e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 54.49 E-value: 6.35e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 13 WVIVFVSFLTQFLCYGsPLAVGVLYIEwlDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGAR--PVTIFSGFMVA 90
Cdd:COG2271 183 WLLALAYFLVYFALYG-FLTWLPTYLV--EVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 91 GGLMLSSFAPNIYFLFFSyGIVVGLGCGLLYTATVTITCQYFDDR-RGLALGLISTGSSVGLFIYAALQRMLVEFYGLDG 169
Cdd:COG2271 260 LALLLLALLPSPALAIAL-LFLAGFGLGGAFGLLWALAAELFPKKaRGTASGLVNTFGFLGGALGPLLVGYLLDATGYQA 338
|
170 180
....*....|....*....|.
gi 1034567082 170 CLLIVGALALNILACGSLMRP 190
Cdd:COG2271 339 AFLLLAALALLAALLALLLLR 359
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
13-190 |
6.96e-08 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 54.50 E-value: 6.96e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 13 WVIVFVSFLTQFLCYGSPLAVGVLYIEwldAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAGG 92
Cdd:cd17473 200 LPIYFLAFLAMLLFYVIPIQLPFLLQE---RGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALG 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 93 LMLSSFAPNIYFLFFSyGIVVGLGCGLLYTATVTITCQYFD-DRRGLALGLISTGSSVGLFIYAALQRMLV-EFYGLDGC 170
Cdd:cd17473 277 FLLLALASGLWVVLLG-AILAGLGFGLLLPTLNSWAMSLVPpELRGRAMGIVTSAFFLGQFLSPLVLGPLVnLTGGLSGA 355
|
170 180
....*....|....*....|
gi 1034567082 171 LLIVGALALnILACGSLMRP 190
Cdd:cd17473 356 FLILGVLAL-VLAIVLLLLR 374
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
14-179 |
8.03e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 54.50 E-value: 8.03e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 14 VIVFVSFLTQFLCYGSPLAVGVLYIEwlDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAGGL 93
Cdd:cd17325 202 LALFLAIFVLAFAFGALEPFLPLYAA--ELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 94 MLSSFAPNIYFLFFSYgIVVGLGCGLLYTATVTITCQYFD-DRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCLL 172
Cdd:cd17325 280 LLLPLATSFWLLLLLL-ALLGLGLGLVFPATLALLADIVPpEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFL 358
|
....*..
gi 1034567082 173 IVGALAL 179
Cdd:cd17325 359 AAAALLL 365
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
309-502 |
1.06e-07 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 53.97 E-value: 1.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 309 LFIAILLFDIGGFPPSLLMEDVARSSNVKEEEFIMpLISIIGIMTAVGKLLLGILADfkWINTLYLYVATLIIMGLALCA 388
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGL-LFALFSLGYALLQPLAGLLAD--RFGRRPVLLLGLLLFALGALL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 389 IPFAKSYVTLALLSGILGFLTGN-WSIFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFS 467
Cdd:cd06174 78 FAFAPSFWLLLLGRFLLGLGSGLiDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLI 157
|
170 180 190
....*....|....*....|....*....|....*
gi 1034567082 468 GFCVLLGGFILLLAALPSWDTCNKQLPKPAPTTFL 502
Cdd:cd06174 158 AAALALLAAILLLLVVPDPPESARAKNEEASSKSV 192
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
345-498 |
1.60e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 53.35 E-value: 1.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 345 LISIIGIMTAVGKLLLGILADFkwINTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGILGFLTG-NWSIFPYVTTKTV 423
Cdd:cd17325 36 IVAAYALAQLLFSPPAGRLSDR--FGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAaVWPAAMALIADIA 113
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034567082 424 GIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTqTYDIAFYFSGFCVLLGGFILLLAALPSWDTCNKQLPKPAP 498
Cdd:cd17325 114 PPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL-GYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAAR 187
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
52-483 |
1.87e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 53.32 E-value: 1.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 52 AWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAGGLMLSSFAPNIYFLFFSyGIVVGLGCGLLYTATVTITCQY 131
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLA-RALAGLAHGGFWAIAAAYAADL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 132 F-DDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCLLIVGALALniLACGSLMRPLqssdcPLPKKIAPEDLPDK 210
Cdd:cd17324 116 VpPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLAL--LAALLLWRLL-----PSLPPKKPGSLGLL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 211 YSIYnekgknleeninildksysseekcritlangdwkqdsLLHKNPTVthtkepetykkkvaeqtyfckqlakrkWQLY 290
Cdd:cd17324 189 SSLL-------------------------------------LLLRNPRL---------------------------RLAY 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 291 knycgeTVALFKNKVFSALF--IAILLFDIGGFPPSllmedvarssnvkeeeFIMPLISIIGIMTAVGKLLLGILADFKW 368
Cdd:cd17324 205 ------LITFLLFGGFFALYtyLAPFLTDVPGFSSS----------------AIIGLLLLFGVAGVVGSPLAGRLADRGG 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 369 INTLYLYVATLIIMGLALCAIPFAksyvTLALLSGILGFLTGNWSIFPYVTTKTVGI--EKLAHAYGILMFFAGLGNSLG 446
Cdd:cd17324 263 RRALLIALLLLAAALLLLTLLGPS----PLLLLVGLVLWGLGFFAAHSALQTRVLRLapEARGLASSLYLAAYNLGGALG 338
|
410 420 430
....*....|....*....|....*....|....*..
gi 1034567082 447 PPIVGWFYDWtqtydiafYFSGFCVLLGGFILLLAAL 483
Cdd:cd17324 339 AALGGLVLDH--------GGWAGVGWVGAALLLLALL 367
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
1-179 |
4.14e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 51.74 E-value: 4.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 1 MELKKSPDGGWGWVIVFVSFLTQFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWVGSlasgVGLLASPVCSLCVSS----F 76
Cdd:COG0477 1 MSSTDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVS----AYLLGRAIGLLLFGRlgdrY 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 77 GARPVTIFSGFMVAGGLMLSSFAPNIYFLFFSYgIVVGLGCGLLYTATVTITCQYFDDR-RGLALGLISTGSSVGLFIYA 155
Cdd:COG0477 77 GRKRVLLIGLLLFGLASLLCGLAPSPELLIAAR-ALQGIGAGGLMPGALALIAELFPAReRGRALGLWGAAIGLGLALGP 155
|
170 180
....*....|....*....|....
gi 1034567082 156 ALQRMLVEFYGLDGCLLIVGALAL 179
Cdd:COG0477 156 LLGGLLVAALGWRWIFLINAPLGL 179
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
299-486 |
5.01e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 52.21 E-value: 5.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 299 ALFKNKVFSALFIAILLFDIGGFPPSLLMEDVARSSNVKEEEFIMPLISIIGIMTAVGKLLLGILAdfKWINTLYLYVAT 378
Cdd:COG2211 223 ALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLA--KRFGKKKAFIIG 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 379 LIIMGLALCAIPFAK--SYVTLALLSGILGFLTG-----NWSIF----PYVTTKTvGIEKLAHAYGILMFFAGLGNSLGP 447
Cdd:COG2211 301 LLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGailvlPWAMLadvvDYDEWKT-GRRREGLYFGIFTFAIKLGQALAG 379
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1034567082 448 PIVGWFYDWT-------QTYDIAFYFSGFCVLLGGFILLLAALPSW 486
Cdd:COG2211 380 ALAGLLLALFgyvagaaQSPSALTGIRLLFFLLPAVLLLLAALLLL 425
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
303-479 |
5.25e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 51.78 E-value: 5.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 303 NKVFSALFIAILLFDIGGFPPSLLmedVARSSNVKEEEFIMPLI-SIIGIMTAVGKLLLGILADFkwINTLYLYVATLII 381
Cdd:cd17370 199 PKAFWLYLLAVALFALGNFSFAFL---ILRAQELGLSAALIPLLyALFNLVYALAAYPAGRLSDR--IGRKKLLILGYLS 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 382 MGLALCAIPFAKSYVTLALLSGILGFLTGNW-SIFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQtY 460
Cdd:cd17370 274 LALAYLGFALGSSLWLLLLGFILWGLYMGAQeSIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLIS-P 352
|
170
....*....|....*....
gi 1034567082 461 DIAFYFSGFCVLLGGFILL 479
Cdd:cd17370 353 SAAFLFSAVLALIALLLLL 371
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
345-482 |
5.82e-07 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 51.81 E-value: 5.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 345 LISIIGIMTAVGKLLLGILAdfKWINTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGILGFltGNWSIFPYVTTKTVG 424
Cdd:cd17473 238 ALAIASLAGAIGALLFGRLK--RRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGL--GFGLLLPTLNSWAMS 313
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034567082 425 IEKLAH-----AYGILMFFagLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLAA 482
Cdd:cd17473 314 LVPPELrgramGIVTSAFF--LGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
298-481 |
6.14e-07 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 51.42 E-value: 6.14e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 298 VALFKNKVFSALFIAILLFDIGGFP----PSLLMEDVARSSNVKeeefIMPLISIIGIMTAVGKLLLGILADFKwINTLY 373
Cdd:cd17474 192 KKALRGRGLLTFLVSAFLYFFLYFAfltyLPFLLELLYGISPII----IGLLFAGWSVLLALGSLFVGRLLKKR-FGARR 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 374 LYVATLIIMGLALCAIPFAKSYVTLALLSGILGFLTGNwsIFPYVTT---KTVGIEKLAHAYGILMFFAGLGNSLGPPIV 450
Cdd:cd17474 267 ILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGL--NLPLLTTlvtELAPEEERGTASSLYNFVRFLGQAVGPLLF 344
|
170 180 190
....*....|....*....|....*....|.
gi 1034567082 451 GWFYDWTQTYdiAFYFSGFCVLLGGFILLLA 481
Cdd:cd17474 345 GLLLEIFGLS--APFLVGAAIALAAAVLLAL 373
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
308-485 |
2.60e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 49.47 E-value: 2.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 308 ALFIAILLFDIGGFPPSLLMEDVARSSNVKEEEFIMpLISIIGIMTAVGKLLLGILADFKWINTLYLYVATLIIMGLALC 387
Cdd:cd17324 3 ALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGL-LVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 388 AipFAKSYVTLALLSGILGFLTGN-WSIFPYVTTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTqTYDIAFYF 466
Cdd:cd17324 82 A--LAPSFALLLLARALAGLAHGGfWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLL-GWRAAFLA 158
|
170
....*....|....*....
gi 1034567082 467 SGFCVLLgGFILLLAALPS 485
Cdd:cd17324 159 IAVLALL-AALLLWRLLPS 176
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
11-189 |
5.54e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 48.70 E-value: 5.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 11 WGWVIVFVSFLTQFLCYGSPLAVGVLYIEWL-DAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMV 89
Cdd:COG0738 207 LKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLkDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLA 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 90 AGGLMLSSFAPNIYFLFFSYgIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDG 169
Cdd:COG0738 287 AVGLLLALLAPGPWLALIGL-ALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRA 365
|
170 180
....*....|....*....|
gi 1034567082 170 CLLIVGALALNILACGSLMR 189
Cdd:COG0738 366 AFLVPLVCYLLILLLALALK 385
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
13-168 |
1.67e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.20 E-value: 1.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 13 WVIVFVSFLTQFLCYGSPLAVGVLYIEwlDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFS-GFMVAG 91
Cdd:COG2211 230 FLLLLLAYLLFFLALALVAALLLYYFK--YVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGlLLAALG 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 92 GLMLSSFAPNIYFLFFSYGIVVGLGCGLLYT---ATVTITCQY-----FDDRRGLALGLISTGSSVGLFIYAALQRMLVE 163
Cdd:COG2211 308 LLLLFFLGPGNLWLLLVLAALAGIGLGAILVlpwAMLADVVDYdewktGRRREGLYFGIFTFAIKLGQALAGALAGLLLA 387
|
....*
gi 1034567082 164 FYGLD 168
Cdd:COG2211 388 LFGYV 392
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
345-477 |
1.98e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 46.78 E-value: 1.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 345 LISIIGIMTAVGKLLLGILADfkWINTLYLYVATLIIMGLALCAIPFAKSY-VTLALLSGILGFLTGnwSIFPY---VTT 420
Cdd:cd17477 228 LLAAFVLGGLLLQWPLGWLAD--RFDRRRVLLGCALLGALAALLLPLVPGLpLALLVLLFLWGGAAG--PLYTLalaLAG 303
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1034567082 421 KTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFI 477
Cdd:cd17477 304 DRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
14-481 |
2.38e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 46.77 E-value: 2.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 14 VIVFVSFLTQFLCYGSplaVGVLYIEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAGGL 93
Cdd:COG0738 11 IAIYLLFFLWGFATAL---WGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 94 MLSSFAPNIYFLFFSYgIVVGLGCGLLYTATVTITCQYFDDRRGLALGLI----STGSSVGLFIYAALQRMLVEFYGLDG 169
Cdd:COG0738 88 LLFALAPSYPLLLLAL-FLLGLGLGLLDVAANPYVAALGPETAASRLNLLhaffSLGALLGPLLGGLLILLGLSLSWHLP 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 170 CLLIVGALALNILACgslmrplqssdcplpkkiapedlpdkysiynekgknleeninildksysseekcritlangdwkq 249
Cdd:COG0738 167 YLILAVLLLLLALLF----------------------------------------------------------------- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 250 dsLLHKNPTVTHTKEPETYKKKvaeqtyfckqlakrkwqlyknycgETVALFKNKVFSALFIAILLF-----DIGGFPPS 324
Cdd:COG0738 182 --LRSKLPEIEEEEEEAAGSAA------------------------SLKSLLKNPRLLLGGLAIFLYvgaegAIGDWLPL 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 325 LLMEDVARSsnvkeEEFIMPLISIIGIMTAVGKLLLGILAD-FKWINTLYLYvaTLIIMGLALCAIPFAKSYVTLALLsG 403
Cdd:COG0738 236 YLKDVLGLS-----EATAALGLSLFWGGMTIGRFLGGFLLKrFGPVRLLRLS--ALLAAVGLLLALLAPGPWLALIGL-A 307
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 404 ILGFLTGNwsIFPyvTTKTVGIEKL----AHAYGILMFFAGLGNSLGPPIVGWFYDWTqTYDIAFYFSGFCVLLGGFILL 479
Cdd:COG0738 308 LVGLGLSL--MFP--TIFSLALDGLgkrtAAAVSAVLIMGIVGGAIGPPLIGFLADAF-GLRAAFLVPLVCYLLILLLAL 382
|
..
gi 1034567082 480 LA 481
Cdd:COG0738 383 AL 384
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
13-179 |
4.24e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 45.88 E-value: 4.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 13 WVIVFVSFLTQFLCYGsplAVGVLYIEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAGG 92
Cdd:cd06174 206 WLLLLAIFLVNLAYYS---FSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMAL 282
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 93 LMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDDR-RGLALGLISTGSSVGLFI-YAALQRMLVEFYGLDGC 170
Cdd:cd06174 283 GLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEiRGTAFGLLNTFGFLGGAIgPLLAGFLLAATFGLTGA 362
|
....*....
gi 1034567082 171 LLIVGALAL 179
Cdd:cd06174 363 FLVLAVLLL 371
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
345-483 |
5.04e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 45.26 E-value: 5.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 345 LISIIGIMTAVGKLLLgILADFKWINTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGILGFLTGnwSIFPYVTT---K 421
Cdd:cd17330 215 LLALVGIAGILAQLLL-IPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTG--IVFPALSAllsK 291
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034567082 422 TVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYdwtqtydiAFYFSGFCVLLGGFILLLAAL 483
Cdd:cd17330 292 SVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLY--------SFLGPGVPFLLAAGLLLIALF 345
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
56-183 |
5.90e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 45.28 E-value: 5.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 56 SLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAGGLMLSSFAPNIYFLFFSyGIVVGLGCGLLYTATVTITCQYFD-D 134
Cdd:cd17489 234 TVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLA-AVLYGLGFGLLFPALQALAVDLVPpH 312
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1034567082 135 RRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCLLIVGALALNILA 183
Cdd:cd17489 313 RRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALV 361
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
76-191 |
6.12e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 45.26 E-value: 6.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 76 FGARPVTIFSGFMVAGGLMLSSFAPNIYFLFFSYGIVvGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYA 155
Cdd:cd17330 61 YGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLD-GLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGP 139
|
90 100 110
....*....|....*....|....*....|....*..
gi 1034567082 156 ALQRMLVEFYGLDGCLLIVGALAL-NILACGSLMRPL 191
Cdd:cd17330 140 ALGGFLSTPYGYALPFLVAAALALlNLVLVLFFLPPL 176
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
13-179 |
2.16e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 43.36 E-value: 2.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 13 WVIVFVSFLTQFLCYGSPLAVGVLYIEWLdafGEGKGKTAWVGSLASGVGLLASPVC-SLCVSSFGARPVTIFSGFMVAG 91
Cdd:cd17490 197 LFFSLLAILQQMITFSTTFGFTPLIAKQL---GASSFQLGLLSIIYLLPNALASLLSgTLFYKKLGERNTIIIGFLLLGA 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 92 GLMLSSFAPNIYFLFFSYgIVVGLGCGLLYTATVTITCQYFD-DRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGC 170
Cdd:cd17490 274 YCFLIPFAPNLTLLYLLQ-ALNGFGTGILFPLLMSLSIEGVPaEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTG 352
|
....*....
gi 1034567082 171 LLIVGALAL 179
Cdd:cd17490 353 FFVIGVIAL 361
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
345-479 |
2.42e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 43.36 E-value: 2.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 345 LISIIGIMTAVGKLLLGILADfkWINTLYLYVATLIIMGLALCAIPFA---KSYVTLALLSGILGFLTGNWSIFPYVTTK 421
Cdd:cd17316 218 YLLLISLGALVGALIAGLLSD--RIGRKKTLVIGLILSGILALPLFYLlsgSPTLLLLLLFILSFFVGGVWGALYAYLAE 295
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1034567082 422 TVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILL 479
Cdd:cd17316 296 LFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
345-479 |
2.77e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 43.38 E-value: 2.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 345 LISIIGIMTAVGKLLLGILADFKWI-NTLYLYVATLIIMGLALCAIPFAKS---YVTLALLSGILGFLTGNWSiFPYVT- 419
Cdd:cd17475 239 LLAVAQLGGALGRIGLGRVSDRVFGgRRRPVLVITAAIAAAALLVLSLLSPgtpLWLLVLLLILLGLFAIGWN-GLYLTl 317
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034567082 420 -TKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILL 479
Cdd:cd17475 318 vAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
20-189 |
2.77e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 43.41 E-value: 2.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 20 FLTQFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAGGLMLSSFA 99
Cdd:cd17355 216 ALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLL 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 100 PNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDDRR-GLALGLISTGSSVGLFIYAALQRMLVEFYGlDGCLLIVGALA 178
Cdd:cd17355 296 PFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSyGTLFGLVFAPHQLGSALGPWLGGLLYDRTG-SYTAAWALAVA 374
|
170
....*....|.
gi 1034567082 179 LNILACGSLMR 189
Cdd:cd17355 375 LGLIAALLVLP 385
|
|
| MFS_Mch1p_like |
cd17354 |
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ... |
345-455 |
3.68e-04 |
|
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340912 [Multi-domain] Cd Length: 385 Bit Score: 43.01 E-value: 3.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 345 LISIIGIMTAVGKLLLGILADF-----KWINTLYLyVATLIIMGLALCAIPFAKSYVTLALLSGILGFLTGN-WSIFPYV 418
Cdd:cd17354 235 LVSLFSIFSFLGRLLSGLLSDLfvrkfRLPRPSRM-VLLLLILSLGHLLQAFGLPSGALYVASALIGFGYGGlFSIAPTI 313
|
90 100 110
....*....|....*....|....*....|....*..
gi 1034567082 419 TTKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYD 455
Cdd:cd17354 314 VSELFGLKNFGTNYGFLMLAPAIGSLIFSVIYAGVYY 350
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
13-153 |
4.17e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.41 E-value: 4.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 13 WVIVFVSFLTQFLCYGSPLAVGVLYIEwldAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARP---VTIFSGFMV 89
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQE---VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRrllLALLLLILA 278
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034567082 90 AGGLMLSSFAPNIYFLFFSYgIVVGLGCGLLYTATVTITCQYFD-DRRGLALGLISTGSSVGLFI 153
Cdd:pfam07690 279 ALGLLLLSLTLSSLWLLLAL-LLLGFGFGLVFPALNALVSDLAPkEERGTASGLYNTAGSLGGAL 342
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
13-189 |
8.44e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 41.79 E-value: 8.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 13 WVIVFVSFLTQFLCYGSPLAVGVLyiewldaFGEGKGKTAWVGSLASG--------VGLLASPVCSLCVSSFGARPVTIF 84
Cdd:cd17504 180 LLANITALLAGFGMFMVFQLLPQL-------LQLPTPTGFGLGITEAGllllpgalVMLIAGPLAGRLIARVGPRRVLLI 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 85 SGFMVAGGLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFD-DRRGLALGLIST----GSSVGLFIYAALQR 159
Cdd:cd17504 253 GLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPpDRTGIATGMNTVlrtiGSAIGPAIAGAILT 332
|
170 180 190
....*....|....*....|....*....|....*....
gi 1034567082 160 MLVEFYGLDGC---------LLIVGALALNILACGSLMR 189
Cdd:cd17504 333 TYTVSITSGGVptegayvlaFLIGAALALAALLLSLLIP 371
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
303-481 |
8.92e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.45 E-value: 8.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 303 NKVFSALFIAILLFDIGGFPPSLLMEDVARSSNVKEEEFIMpLISIIGIMTAVGKLLLGILADFKwiNTLYLYVATLIIM 382
Cdd:cd06173 208 PLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGL-LLAAFGVGALLGALLLGRLSKRR--RRGRLLLIGALLL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 383 GLALCAIPFAKSYVTLALLSGILGFLTGNWSIfPYVTT--KTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTqTY 460
Cdd:cd06173 285 GLALLVLGLSPSLWLLLAALFLLGLAGGLFNV-PLNTLlqLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADAL-GL 362
|
170 180
....*....|....*....|.
gi 1034567082 461 DIAFYFSGFCVLLGGFILLLA 481
Cdd:cd06173 363 SAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
347-481 |
9.52e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.43 E-value: 9.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 347 SIIGIMTAVGKLLLGILADFKwiNTLYLYVATLIIMGLALCAIPFAKSyVTLALLSGILgFLTGNWSIFPYVTTKTVGI- 425
Cdd:cd17489 234 TVYAIALLLSRPFSGKLSDRK--GPKTVIIPGLLLLALGLLLLSFAGS-PWMLLLAAVL-YGLGFGLLFPALQALAVDLv 309
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1034567082 426 --EKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQtYDIAFYFSGFCVLLGGFILLLA 481
Cdd:cd17489 310 ppHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG-YRAMFLLAAVVVLLALVLYIFL 366
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
16-157 |
1.06e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 41.39 E-value: 1.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 16 VFVSFLTqFLCYGSPLAVGVLYiewldaFGEGKGKTAWVGSLA----SGVGLLASPVCSLCVSSFGARPVTIFSGFMVAG 91
Cdd:cd17321 174 VLAAFLL-GAALGGLLFLLPLY------LQGVLGYSPLQAGLAllplALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAV 246
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034567082 92 GLMLSSF--APNIYFLFFSYGIVVGLGCGLLYTA-TVTITCQYFDDRRGLALGLIST----GSSVGLFIYAAL 157
Cdd:cd17321 247 GLLLLALlgADSSVWLLLPGLVLLGLGLGLFATPlTNAALSSVPKEKAGAASGILNTarqlGGALGVALLGAL 319
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
76-201 |
1.20e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 41.00 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 76 FGARPVTIFSGFMVAGGLMLSSFAPNIYFLFFSYgIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYA 155
Cdd:cd17478 58 KPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLV-ALAGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGP 136
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1034567082 156 ALQRMLVEFYGLDGcLLIVGALALniLACGSLMRPLQSSDCPLPKK 201
Cdd:cd17478 137 LIAAALVALFGGLG-LLILLIIPG--LAVALLLLRLRPLKKPEAKK 179
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
283-479 |
1.85e-03 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 40.68 E-value: 1.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 283 AKRKWQLYKNYCGETVALFKNKVF--SALFIAILLFDIGG---FPPSLLMEdvARSSNVKEEEFIMPLISIIGIMTAV-G 356
Cdd:cd17328 186 GVMAKSTATSFLADLKALAKNPSFilSTLGFTAVSFVTGAlafWAPTFFLR--AFGVGDLSSADVGLIFGAITCIAGVlG 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 357 KLLLGILADF--KWINTLYLYVATLIIMGLALC---AIPFAKS--YVTLALLSGILGFLTGNWSIFPYVTTKTVGIEKLA 429
Cdd:cd17328 264 VLLGGILADRlrRKTPRADPLVCAVGLLAAAPFlflALVLALSnlLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRS 343
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034567082 430 HAYGILMFFAG-LGNSLGPPIVGWFYDWTQTYDI-----------AFYFSGFCVLLGGFILL 479
Cdd:cd17328 344 TASAIQILLSHlLGDAGSPYLIGLISDLLRQNKDsplaeaaslqyALLLCSFVLVLGGFFFL 405
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
15-189 |
2.13e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 40.27 E-value: 2.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 15 IVFVSFLtQFLCYGSPLAVGVLYIEwldafgEGKGKTAWVG---SLASGVGLLASPVCSLCVSSFGARPVTIFSGFMVAG 91
Cdd:cd17489 1 ILLANFF-FFLSFYLLLPVLPLYAH------DLGGSEAVAGlvvGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFAL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 92 GLMLSSFAPNIyFLFFSYGIVVGLGCGLLYTATVTITCQYFD-DRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGC 170
Cdd:cd17489 74 ATLLYLLATSV-ALLLVLRLIHGIGWGAFTTAAATLVADIIPpSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVL 152
|
170
....*....|....*....
gi 1034567082 171 LLIVGALALNILACGSLMR 189
Cdd:cd17489 153 FIVAAVLALLALLLVFLVK 171
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
9-188 |
2.66e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 39.93 E-value: 2.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 9 GGWGWVIVFVSFLTqFLCYGSPLAVGVLYIEWLDAFGEGKGKTAWVG-SLASGVGLLASpvcSLCVSSFGARPVTIFSGF 87
Cdd:cd17393 198 NRLLLLLGLLALAA-ALAEGAAADWSALYLRDVLGASAALAALGYAVfSLAMTVGRLFG---DRLVDRFGDVAVLRAGAL 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 88 MVAGGLMLSSFAPNIYFLFFSYGIvVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYGL 167
Cdd:cd17393 274 LAALGLLLALLAPSVWVALAGFAL-MGLGLSVVVPLAFSAAGALPGLAAGIAVARVATLGYLGFLVGPPLIGFLADATGL 352
|
170 180
....*....|....*....|.
gi 1034567082 168 DGCLLIVGALALNILACGSLM 188
Cdd:cd17393 353 RTAFLVVALLALLVALLARAV 373
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
64-177 |
2.82e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 39.94 E-value: 2.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 64 LASPVCSLCVSSFGARPVTIFSGFMVAGGLMLSSFAPNIYFLFFsYGIVVGLGCGLLYTATVTITCQYFDDRRGLALGLI 143
Cdd:cd17391 51 IFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLI-LRLLQGVFSGYVPNATALIASQTPKEKSGWALGTL 129
|
90 100 110
....*....|....*....|....*....|....
gi 1034567082 144 STGSSVGLFIYAALQRMLVEFYGLDGCLLIVGAL 177
Cdd:cd17391 130 STGVVAGTLIGPLLGGFLADLFGIRNVFFITGGL 163
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
346-480 |
3.07e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.90 E-value: 3.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 346 ISIIGIMTAVGKLLLGILADFKWINTLYLYVATLI---IMGLALCAIPFAKSYVTLALLSGILGFLTGnwSIFPYVTT-- 420
Cdd:cd17490 232 LGLLSIIYLLPNALASLLSGTLFYKKLGERNTIIIgflLLGAYCFLIPFAPNLTLLYLLQALNGFGTG--ILFPLLMSls 309
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034567082 421 -KTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTqTYDIAFYFSGFCVLLGGFILLL 480
Cdd:cd17490 310 iEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAF-GLQTGFFVIGVIALLAAILSLA 369
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
345-480 |
3.54e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 39.67 E-value: 3.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 345 LISIIGIMTAVGKLLLGILADFKwiNTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGILGFLTG-NWSIFPYVTTKTV 423
Cdd:TIGR00881 35 LLSSFSIAYGISKFVMGSVSDRS--NPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGmGWPPCGRTVTKWF 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034567082 424 GIEKLAHAYGILMFFAGLGNSLGPPIVG----WFYDWTQTydiaFYFSGFCVLLGGFILLL 480
Cdd:TIGR00881 113 SRSERGTWVSFWNCSHNVGGGLLPPLVLfgiaELYSWHWV----FIVPGIIAIIVSLICFL 169
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
345-506 |
3.80e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.50 E-value: 3.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 345 LISIIGIMTAVGKLLLGILAD---FKWIntlylYVATLIIMGLALCAIPFAKSYVTLALLSGILGFltgNWSIFPYVT-- 419
Cdd:cd17489 36 VVGLFTLAALLARPFAGRLLDrfgRKRL-----LLIGLLIFALATLLYLLATSVALLLVLRLIHGI---GWGAFTTAAat 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 420 --TKTVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTQtYDIAFYFSGFCVLLG-GFILLLAALPSWDTCNKQLPKP 496
Cdd:cd17489 108 lvADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG-FAVLFIVAAVLALLAlLLVFLVKDPPPVAAEEAEAGTR 186
|
170
....*....|
gi 1034567082 497 APTTFLYKVA 506
Cdd:cd17489 187 AFRRLVEKKV 196
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
345-480 |
4.75e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 39.02 E-value: 4.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 345 LISIIGIMTAVGKLLLGILADfkWINTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGILGF-LTGNWSIFPYVTTKTV 423
Cdd:COG0477 54 IVSAYLLGRAIGLLLFGRLGD--RYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIgAGGLMPGALALIAELF 131
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 1034567082 424 GIEKLAHAYGILMFFAGLGNSLGPPIVGWFYDWTqTYDIAFYFSGFCVLLGGFILLL 480
Cdd:COG0477 132 PARERGRALGLWGAAIGLGLALGPLLGGLLVAAL-GWRWIFLINAPLGLLALVLRLR 187
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
57-179 |
5.33e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.06 E-value: 5.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 57 LASGVGLLASPVCSLCVSSFGARPVTIF---SGFMVAGGLMLSSFAPNIYFLFFSYGIVVGLGCGLLYTATVTITCqyfD 133
Cdd:cd17370 242 LFNLVYALAAYPAGRLSDRIGRKKLLILgylSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVP---A 318
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1034567082 134 DRRGLALGLISTGSSVGLFIYAALQRMLVEFYGLDGCLLIVGALAL 179
Cdd:cd17370 319 ELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLAL 364
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
11-188 |
6.02e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 39.10 E-value: 6.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 11 WGWVIVFVSFLTQFLCYGSplAVGVLYIEwldAFGEGKGKTAWVGSLASGVGLLASPVCSLCVSSFGARPVTIFS-GFMV 89
Cdd:cd17320 204 LGYALALGLSFAGLFAYLA--AAPFIYIE---QLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGlLLLL 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 90 AGGLMLSSFA---PNIYFLFFSYGIVVGLGCGLLYTATVTITCQYFDDRRGLALGLISTGSSVGLFIYAALQRMLVEFYG 166
Cdd:cd17320 279 AAALVLLLAAllgGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTA 358
|
170 180
....*....|....*....|..
gi 1034567082 167 LdgcLLIVGALALNILACGSLM 188
Cdd:cd17320 359 L---PMGLLILVLGLLALLLLI 377
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
345-500 |
8.77e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 38.31 E-value: 8.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 345 LISIIGIMTAVGKLLLGILADFKwiNTLYLYVATLIIMGLALCAIPFAKSYVTLALLSGILGFltGNwSIF-P--YVTTK 421
Cdd:cd17478 36 LVSVFSITSSLLQPLFGYLADRK--PRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGI--GS-AAFhPegARLAS 110
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034567082 422 TVGIEKLAHAYGILMFFAGLGNSLGPPIVGWFydwtqtYDIAFYFSGFCVLLGGFILLLAALPSWDTCNKQLPKPAPTT 500
Cdd:cd17478 111 QAAGGRRGLAMSIFSVGGNLGFALGPLIAAAL------VALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAK 183
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
351-482 |
9.51e-03 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 38.30 E-value: 9.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034567082 351 IMTAVGKLLLGILADF------------KWINTLylyvaTLIIMGLALCAIPFAKSYVT-LALLSGILGFLTGNWSIFpY 417
Cdd:cd17380 223 LVMFPSSNVAGWLADHlisrgwtvtsvrKLMQSI-----GFLGPALFLLLLSHTDSFSLaLLCMSVALGLSAFSSSGV-L 296
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034567082 418 VTTKTVGIEklaHAyGILMffaGLGNS-------LGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFILLLAA 482
Cdd:cd17380 297 VNHQDIAPN---YA-GIVF---GISNTagtipgiVGVYLTGYILEATGSWSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| |
