NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1034574855|ref|XP_016873595|]
View 

ribonuclease inhibitor isoform X1 [Homo sapiens]

Protein Classification

ribonuclease inhibitor( domain architecture ID 10061476)

ribonuclease inhibitor inhibits RNASE1, RNASE2 and ANG, and may play a role in redox homeostasis

Gene Ontology:  GO:0008428|GO:0005515
PubMed:  11751054

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 6-325 1.10e-105

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


:

Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 316.60  E-value: 1.10e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855   6 QSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELG--DVGVHCVLQGLQTp 83
Cdd:cd00116     1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTK- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855  84 SCKIQKLSLQNCCLTGAGCGVLSSTLRTlPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLA 163
Cdd:cd00116    80 GCGLQELDLSDNALGPDGCGVLESLLRS-SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855 164 SVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSpCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVG 243
Cdd:cd00116   159 KALRANRDLKELNLANNGIGDAGIRALAEGLKAN-CNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAG 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855 244 MAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSC 323
Cdd:cd00116   238 AAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKDD 317


                  ..
gi 1034574855 324 SF 325
Cdd:cd00116   318 SF 319
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 228-430 5.74e-19

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 88.69  E-value: 5.74e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855 228 SLRELALGSNKLGDVGMAELCPGLLHPSSrLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCEt 307
Cdd:COG5238   181 SVETVYLGCNQIGDEGIEELAEALTQNTT-VTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAE- 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855 308 LLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLgQPGSVLRVLWLADCDVSDSSC 387
Cdd:COG5238   259 ALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGL-QGNKTLHTLNLAYNGIGAQGA 337

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1034574855 388 SSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLE 430
Cdd:COG5238   338 IALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRE 380
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 6-325 1.10e-105

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 316.60  E-value: 1.10e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855   6 QSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELG--DVGVHCVLQGLQTp 83
Cdd:cd00116     1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTK- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855  84 SCKIQKLSLQNCCLTGAGCGVLSSTLRTlPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLA 163
Cdd:cd00116    80 GCGLQELDLSDNALGPDGCGVLESLLRS-SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855 164 SVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSpCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVG 243
Cdd:cd00116   159 KALRANRDLKELNLANNGIGDAGIRALAEGLKAN-CNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAG 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855 244 MAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSC 323
Cdd:cd00116   238 AAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKDD 317


                  ..
gi 1034574855 324 SF 325
Cdd:cd00116   318 SF 319
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 228-430 5.74e-19

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 88.69  E-value: 5.74e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855 228 SLRELALGSNKLGDVGMAELCPGLLHPSSrLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCEt 307
Cdd:COG5238   181 SVETVYLGCNQIGDEGIEELAEALTQNTT-VTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAE- 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855 308 LLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLgQPGSVLRVLWLADCDVSDSSC 387
Cdd:COG5238   259 ALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGL-QGNKTLHTLNLAYNGIGAQGA 337

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1034574855 388 SSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLE 430
Cdd:COG5238   338 IALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRE 380
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 5-261 1.31e-18

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 87.54  E-value: 1.31e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855   5 IQSLDIQCEELSDARWAELLPLLQQCQVVR---LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQ 81
Cdd:COG5238   182 VETVYLGCNQIGDEGIEELAEALTQNTTVTtlwLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALK 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855  82 TPScKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCrLEKLQLEYCSLSAASCEP 161
Cdd:COG5238   262 NNT-TVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKT-LHTLNLAYNGIGAQGAIA 339

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPcqlealklescgvtsdncrdlcgivaskaSLRELALGSNKLGD 241
Cdd:COG5238   340 LAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNT-----------------------------TLRELNLGKNNIGK 390

                         250       260
                  ....*....|....*....|
gi 1034574855 242 VGMAELCPGLLHpsSRLRTL 261
Cdd:COG5238   391 QGAEALIDALQT--NRLHTL 408
LRR_RI_capping pfam18779
Capping Ribonuclease inhibitor Leucine Rich Repeat; Leucine-rich repeats are composed of a ...
 6-35 3.34e-10

Capping Ribonuclease inhibitor Leucine Rich Repeat; Leucine-rich repeats are composed of a beta-alpha unit. This repeat unit is found as capping unit (N- or C- terminal of the repeat region) of Ribonuclease Inhibitors.


Pssm-ID: 436731  Cd Length: 30  Bit Score: 54.81  E-value: 3.34e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 1034574855   6 QSLDIQCEELSDARWAELLPLLQQCQVVRL 35
Cdd:pfam18779   1 MDLDIQCEELSDSRWAELLPSMQQCKVVRL 30
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
397-424 1.50e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 38.54  E-value: 1.50e-04
                           10        20
                   ....*....|....*....|....*...
gi 1034574855  397 NHSLRELDLSNNCLGDAGILQLVESVRQ 424
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
283-308 9.81e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 36.23  E-value: 9.81e-04
                           10        20
                   ....*....|....*....|....*.
gi 1034574855  283 KESLKELSLAGNELGDEGARLLCETL 308
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEAL 26
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 6-325 1.10e-105

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 316.60  E-value: 1.10e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855   6 QSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELG--DVGVHCVLQGLQTp 83
Cdd:cd00116     1 LQLSLKGELLKTERATELLPKLLCLQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGriPRGLQSLLQGLTK- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855  84 SCKIQKLSLQNCCLTGAGCGVLSSTLRTlPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLA 163
Cdd:cd00116    80 GCGLQELDLSDNALGPDGCGVLESLLRS-SSLQELKLNNNGLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855 164 SVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSpCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVG 243
Cdd:cd00116   159 KALRANRDLKELNLANNGIGDAGIRALAEGLKAN-CNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAG 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855 244 MAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSC 323
Cdd:cd00116   238 AAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNELESLWVKDD 317


                  ..
gi 1034574855 324 SF 325
Cdd:cd00116   318 SF 319
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 228-430 5.74e-19

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 88.69  E-value: 5.74e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855 228 SLRELALGSNKLGDVGMAELCPGLLHPSSrLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCEt 307
Cdd:COG5238   181 SVETVYLGCNQIGDEGIEELAEALTQNTT-VTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAE- 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855 308 LLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLgQPGSVLRVLWLADCDVSDSSC 387
Cdd:COG5238   259 ALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGL-QGNKTLHTLNLAYNGIGAQGA 337

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1034574855 388 SSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLE 430
Cdd:COG5238   338 IALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRE 380
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 5-261 1.31e-18

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 87.54  E-value: 1.31e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855   5 IQSLDIQCEELSDARWAELLPLLQQCQVVR---LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQ 81
Cdd:COG5238   182 VETVYLGCNQIGDEGIEELAEALTQNTTVTtlwLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEALK 261

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855  82 TPScKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCrLEKLQLEYCSLSAASCEP 161
Cdd:COG5238   262 NNT-TVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKT-LHTLNLAYNGIGAQGAIA 339

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPcqlealklescgvtsdncrdlcgivaskaSLRELALGSNKLGD 241
Cdd:COG5238   340 LAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNT-----------------------------TLRELNLGKNNIGK 390

                         250       260
                  ....*....|....*....|
gi 1034574855 242 VGMAELCPGLLHpsSRLRTL 261
Cdd:COG5238   391 QGAEALIDALQT--NRLHTL 408
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 114-308 7.70e-17

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 82.53  E-value: 7.70e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855 114 TLQELHLSDNLLGDAGLQLLCEGLLDPQcRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQG 193
Cdd:COG5238   181 SVETVYLGCNQIGDEGIEELAEALTQNT-TVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIALAEA 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855 194 LKdSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHpSSRLRTLWIWECGITAKGC 273
Cdd:COG5238   260 LK-NNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQG-NKTLHTLNLAYNGIGAQGA 337

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1034574855 274 GDLCRVLRAKESLKELSLAGNELGDEGARLLCETL 308
Cdd:COG5238   338 IALAKALQENTTLHSLDLSDNQIGDEGAIALAKYL 372
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 147-450 1.12e-16

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 81.76  E-value: 1.12e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855 147 LQLEYCSLSaasCEPLASVLRAKPDFKELTV--SNNDINEAGVRVLCQGLKDSPcQLEALKLESCGVTSDNCRDLCGIVA 224
Cdd:COG5238   158 LLGLAARLG---LLAAISMAKALQNNSVETVylGCNQIGDEGIEELAEALTQNT-TVTTLWLKRNPIGDEGAEILAEALK 233

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSrLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLL 304
Cdd:COG5238   234 GNKSLTTLDLSNNQIGDEGVIALAEALKNNTT-VETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIAL 312

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855 305 CETLlEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQglgqpgsvlrvlwladcdvsd 384
Cdd:COG5238   313 AEGL-QGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAK--------------------- 370

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034574855 385 sscsslaatLLANH-SLRELDLSNNCLGDAGILQLVESVRqpGCLLEQLVLYDIYWSEEMEDRLQAL 450
Cdd:COG5238   371 ---------YLEGNtTLRELNLGKNNIGKQGAEALIDALQ--TNRLHTLILDGNLIGAEAQQRLEQL 426
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 5-195 3.45e-12

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 67.89  E-value: 3.45e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855   5 IQSLDIQCEELSDARWAELLPLLQ-QCQVVRLDDCG--LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQ 81
Cdd:COG5238   238 LTTLDLSNNQIGDEGVIALAEALKnNTTVETLYLSGnqIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQ 317

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855  82 TPScKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQcRLEKLQLEYCSLSAASCEP 161
Cdd:COG5238   318 GNK-TLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNT-TLRELNLGKNNIGKQGAEA 395

                         170       180       190
                  ....*....|....*....|....*....|....
gi 1034574855 162 LASVLRaKPDFKELTVSNNDINEAGVRVLCQGLK 195
Cdd:COG5238   396 LIDALQ-TNRLHTLILDGNLIGAEAQQRLEQLLE 428
LRR_RI_capping pfam18779
Capping Ribonuclease inhibitor Leucine Rich Repeat; Leucine-rich repeats are composed of a ...
 6-35 3.34e-10

Capping Ribonuclease inhibitor Leucine Rich Repeat; Leucine-rich repeats are composed of a beta-alpha unit. This repeat unit is found as capping unit (N- or C- terminal of the repeat region) of Ribonuclease Inhibitors.


Pssm-ID: 436731  Cd Length: 30  Bit Score: 54.81  E-value: 3.34e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 1034574855   6 QSLDIQCEELSDARWAELLPLLQQCQVVRL 35
Cdd:pfam18779   1 MDLDIQCEELSDSRWAELLPSMQQCKVVRL 30
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-182 6.10e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.31  E-value: 6.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855   4 DIQSLDIQCEELSDarWAELLPLLQQCQVVRLDDCGLTearckDISSALRVNPALAELNLRSNELGDVGVHcvLQGLQtp 83
Cdd:COG4886   114 NLESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLT-----DLPEPLGNLTNLKSLDLSNNQLTDLPEE--LGNLT-- 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034574855  84 scKIQKLSLQNCCLTgagcgVLSSTLRTLPTLQELHLSDNLLGDAGLQLlceglldPQC-RLEKLQLEYCSLSAascepl 162
Cdd:COG4886   183 --NLKELDLSNNQIT-----DLPEPLGNLTNLEELDLSGNQLTDLPEPL-------ANLtNLETLDLSNNQLTD------ 242

                         170       180
                  ....*....|....*....|
gi 1034574855 163 ASVLRAKPDFKELTVSNNDI 182
Cdd:COG4886   243 LPELGNLTNLEELDLSNNQL 262
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
397-424 1.50e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 38.54  E-value: 1.50e-04
                           10        20
                   ....*....|....*....|....*...
gi 1034574855  397 NHSLRELDLSNNCLGDAGILQLVESVRQ 424
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
283-308 9.81e-04

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 36.23  E-value: 9.81e-04
                           10        20
                   ....*....|....*....|....*.
gi 1034574855  283 KESLKELSLAGNELGDEGARLLCETL 308
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEAL 26
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
112-139 1.02e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 36.23  E-value: 1.02e-03
                           10        20
                   ....*....|....*....|....*...
gi 1034574855  112 LPTLQELHLSDNLLGDAGLQLLCEGLLD 139
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
LRR_RI smart00368
Leucine rich repeat, ribonuclease inhibitor type;
340-367 3.92e-03

Leucine rich repeat, ribonuclease inhibitor type;


Pssm-ID: 197686 [Multi-domain]  Cd Length: 28  Bit Score: 34.69  E-value: 3.92e-03
                           10        20
                   ....*....|....*....|....*...
gi 1034574855  340 NRFLLELQISNNRLEDAGVRELCQGLGQ 367
Cdd:smart00368   1 NPSLRELDLSNNKLGDEGARALAEALKD 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH