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Conserved domains on  [gi|1034592371|ref|XP_016878219|]
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GPI mannosyltransferase 3 isoform X3 [Homo sapiens]

Protein Classification

glycosyltransferase family protein( domain architecture ID 229536)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PMT_2 super family cl21590
Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are ...
 7-316 2.75e-89

Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are not captured by pfam02366.


The actual alignment was detected with superfamily member pfam03901:

Pssm-ID: 473917  Cd Length: 414  Bit Score: 276.55  E-value: 2.75e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034592371   7 IWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSM--- 83
Cdd:pfam03901  80 FYAPRLLLGLFSALCDYYLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLEYGNTSVsny 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034592371  84 -NSVKYSSLVALAFIIRPTAVILWTPLLFRHFCQEPRK-LDLILHHFLPVGFVTLSLSL----MIDRIFFGQWTLVQFNF 157
Cdd:pfam03901 160 kYLKAVLLIAALAILGRPTSALLWLPLVLYLLLRLRGKrLKLFLFLAISLGLLVALLVLgaviLIDSYFYGRFVFTPLNF 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034592371 158 LKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLV----YSMLSHKEFRFIYPV 233
Cdd:pfam03901 240 LKYNVLSNGSSFYGTHPWYFYFSNGLPNILGPFLLAFILGPLVLLLRKVSRLSQLLAPILIwlfiYSLQPHKEERFLYPV 319

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034592371 234 LPFCMVFCGYSLTHLK--TWKKPA----LSFLFLSNLFLALYTGLVHQRGTL----DVMSHIQKVC--YNNPNKSSASIF 301
Cdd:pfam03901 320 YPLILLSAAIALTRLSrrSWKVRKklslLFLLLFFNVSLARLFGLVHQYGAPlavyDVMSFLNETPreNRNPAGPPVNVC 399

                         330
                  ....*....|....*
gi 1034592371 302 IMMPCHSTPYYSHVH 316
Cdd:pfam03901 400 IGMECYSTPSSFFLH 414
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 7-316 2.75e-89

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 276.55  E-value: 2.75e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034592371   7 IWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSM--- 83
Cdd:pfam03901  80 FYAPRLLLGLFSALCDYYLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLEYGNTSVsny 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034592371  84 -NSVKYSSLVALAFIIRPTAVILWTPLLFRHFCQEPRK-LDLILHHFLPVGFVTLSLSL----MIDRIFFGQWTLVQFNF 157
Cdd:pfam03901 160 kYLKAVLLIAALAILGRPTSALLWLPLVLYLLLRLRGKrLKLFLFLAISLGLLVALLVLgaviLIDSYFYGRFVFTPLNF 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034592371 158 LKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLV----YSMLSHKEFRFIYPV 233
Cdd:pfam03901 240 LKYNVLSNGSSFYGTHPWYFYFSNGLPNILGPFLLAFILGPLVLLLRKVSRLSQLLAPILIwlfiYSLQPHKEERFLYPV 319

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034592371 234 LPFCMVFCGYSLTHLK--TWKKPA----LSFLFLSNLFLALYTGLVHQRGTL----DVMSHIQKVC--YNNPNKSSASIF 301
Cdd:pfam03901 320 YPLILLSAAIALTRLSrrSWKVRKklslLFLLLFFNVSLARLFGLVHQYGAPlavyDVMSFLNETPreNRNPAGPPVNVC 399

                         330
                  ....*....|....*
gi 1034592371 302 IMMPCHSTPYYSHVH 316
Cdd:pfam03901 400 IGMECYSTPSSFFLH 414
PLN02816 PLN02816
mannosyltransferase
 10-407 1.28e-84

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 268.83  E-value: 1.28e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034592371  10 PRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMN---SV 86
Cdd:PLN02816  121 PRLMQSIFSAIGDLYLYKLSDALYGGNVATWSLFCQMANWFIFFCLNRTFSNCLETVLTIMGLYYWPCIRDSSIDypvNR 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034592371  87 KYS-SLVALAFIIRPTAVILWTPLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQN 165
Cdd:PLN02816  201 KWGlVIAALACAIRPTSAVIWLYVGMLELFLTPNKVKFIILEVIPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFNFLSS 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034592371 166 WGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYlaPKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSL 245
Cdd:PLN02816  281 GGDYYGTHPWHWYFTQGFLVMLFTFTPFSIAGII--KSKNQKLSALILWVLAIYSILGHKEFRFVLPVLPIALIFSGYAF 358

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034592371 246 THLK----------TWKK-----------PALS----FLFLSNLFLALYTGLVHQRGTLDVMSHIQKVCYNNPNKssaSI 300
Cdd:PLN02816  359 AQMEvsgssssssvTKKKqvprqnhtkwsPKLRlsvyFLLATNIPMALYMSLFHQRGTEDAMNYLSDEAYKGRVK---SI 435

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034592371 301 FIMMPCHSTPYYSHVHCPLPMRFLQCPPdlTGKSHYLDEADVFYLNPLNWLHREFHDDASLPTHLITFSILEEEISAFLI 380
Cdd:PLN02816  436 LFLMPCHSTPYYSTLHRNIPMQFLDCTP--SAEKGELDESDQFLVNPLGFASELARNWSEPPSHIVLFASEETKLRDFMI 513

                         410       420
                  ....*....|....*....|....*...
gi 1034592371 381 SSNYKRTAVFFHTHLPEGR-IGSHIYVY 407
Cdd:PLN02816  514 QHSFKEVRRFFHAHFKVDRdLQSSVVVY 541
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 7-316 2.75e-89

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 276.55  E-value: 2.75e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034592371   7 IWIPRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSM--- 83
Cdd:pfam03901  80 FYAPRLLLGLFSALCDYYLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLEYGNTSVsny 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034592371  84 -NSVKYSSLVALAFIIRPTAVILWTPLLFRHFCQEPRK-LDLILHHFLPVGFVTLSLSL----MIDRIFFGQWTLVQFNF 157
Cdd:pfam03901 160 kYLKAVLLIAALAILGRPTSALLWLPLVLYLLLRLRGKrLKLFLFLAISLGLLVALLVLgaviLIDSYFYGRFVFTPLNF 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034592371 158 LKFNVLQNWGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYLAPKRYRILLVTVLWTLLV----YSMLSHKEFRFIYPV 233
Cdd:pfam03901 240 LKYNVLSNGSSFYGTHPWYFYFSNGLPNILGPFLLAFILGPLVLLLRKVSRLSQLLAPILIwlfiYSLQPHKEERFLYPV 319

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034592371 234 LPFCMVFCGYSLTHLK--TWKKPA----LSFLFLSNLFLALYTGLVHQRGTL----DVMSHIQKVC--YNNPNKSSASIF 301
Cdd:pfam03901 320 YPLILLSAAIALTRLSrrSWKVRKklslLFLLLFFNVSLARLFGLVHQYGAPlavyDVMSFLNETPreNRNPAGPPVNVC 399

                         330
                  ....*....|....*
gi 1034592371 302 IMMPCHSTPYYSHVH 316
Cdd:pfam03901 400 IGMECYSTPSSFFLH 414
PLN02816 PLN02816
mannosyltransferase
 10-407 1.28e-84

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 268.83  E-value: 1.28e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034592371  10 PRLAQALLSAVADVRLYSLMKQLENQEVARWVFFCQLCSWFTWYCCTRTLTNTMETVLTIIALFYYPLEGSKSMN---SV 86
Cdd:PLN02816  121 PRLMQSIFSAIGDLYLYKLSDALYGGNVATWSLFCQMANWFIFFCLNRTFSNCLETVLTIMGLYYWPCIRDSSIDypvNR 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034592371  87 KYS-SLVALAFIIRPTAVILWTPLLFRHFCQEPRKLDLILHHFLPVGFVTLSLSLMIDRIFFGQWTLVQFNFLKFNVLQN 165
Cdd:PLN02816  201 KWGlVIAALACAIRPTSAVIWLYVGMLELFLTPNKVKFIILEVIPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFNFLSS 280

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034592371 166 WGTFYGSHPWHWYFSQGFPVILGTHLPFFIHGCYlaPKRYRILLVTVLWTLLVYSMLSHKEFRFIYPVLPFCMVFCGYSL 245
Cdd:PLN02816  281 GGDYYGTHPWHWYFTQGFLVMLFTFTPFSIAGII--KSKNQKLSALILWVLAIYSILGHKEFRFVLPVLPIALIFSGYAF 358

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034592371 246 THLK----------TWKK-----------PALS----FLFLSNLFLALYTGLVHQRGTLDVMSHIQKVCYNNPNKssaSI 300
Cdd:PLN02816  359 AQMEvsgssssssvTKKKqvprqnhtkwsPKLRlsvyFLLATNIPMALYMSLFHQRGTEDAMNYLSDEAYKGRVK---SI 435

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034592371 301 FIMMPCHSTPYYSHVHCPLPMRFLQCPPdlTGKSHYLDEADVFYLNPLNWLHREFHDDASLPTHLITFSILEEEISAFLI 380
Cdd:PLN02816  436 LFLMPCHSTPYYSTLHRNIPMQFLDCTP--SAEKGELDESDQFLVNPLGFASELARNWSEPPSHIVLFASEETKLRDFMI 513

                         410       420
                  ....*....|....*....|....*...
gi 1034592371 381 SSNYKRTAVFFHTHLPEGR-IGSHIYVY 407
Cdd:PLN02816  514 QHSFKEVRRFFHAHFKVDRdLQSSVVVY 541
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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