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Conserved domains on  [gi|1034595434|ref|XP_016878993|]
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myocardin-related transcription factor B isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 389-422 2.73e-10

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


:

Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 56.25  E-value: 2.73e-10
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1034595434  389 LDDLKVSELKTELKLRGLPVSGTKPDLIERLKPY 422
Cdd:pfam02037    1 LSKLTVAELKEELRKRGLPTSGKKAELIERLQEY 34
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
128-153 1.45e-05

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


:

Pssm-ID: 128947  Cd Length: 26  Bit Score: 42.46  E-value: 1.45e-05
                            10        20
                    ....*....|....*....|....*.
gi 1034595434   128 DDLNEKIAQRPGPMELVEKNILPVDS 153
Cdd:smart00707    1 DVLNRKLSQRPTREELEERNILKELS 26
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 186-399 7.04e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 7.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595434  186 PDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVPEflkTPPTADQP--PPRPAAPVLPTNTV-SSAKPGP 262
Cdd:PHA03247  2784 TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPL---PPPTSAQPtaPPPPPGPPPPSLPLgGSVAPGG 2860

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595434  263 ALVK----QSHPKNPNDKHRSKKCKDPKPRVKKLKYHQYIPPDQKGEKNEPQmdsnyarLLQQQQLFLQLQILSQQKQHY 338
Cdd:PHA03247  2861 DVRRrppsRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQ-------APPPPQPQPQPPPPPQPQPPP 2933

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034595434  339 NYQTILPAPFKPLNDKNSNSG---------NSALNNATPNTPRQNTSTP---VRKPGPLPSSLDDLKVSELKT 399
Cdd:PHA03247  2934 PPPPRPQPPLAPTTDPAGAGEpsgavpqpwLGALVPGRVAVPRFRVPQPapsREAPASSTPPLTGHSLSRVSS 3006
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 85-108 1.81e-04

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


:

Pssm-ID: 460677  Cd Length: 24  Bit Score: 39.56  E-value: 1.81e-04
                           10        20
                   ....*....|....*....|....
gi 1034595434   85 FLKHKIRSRPDRSELVRMHILEET 108
Cdd:pfam02755    1 SLERKLSHRPTREELVERNILPED 24
DUF2130 super family cl38307
Uncharacterized protein conserved in bacteria (DUF2130); This domain, found in various ...
 557-592 2.29e-04

Uncharacterized protein conserved in bacteria (DUF2130); This domain, found in various hypothetical prokaryotic proteins, has no known function.


The actual alignment was detected with superfamily member pfam09903:

Pssm-ID: 430914 [Multi-domain]  Cd Length: 248  Bit Score: 44.15  E-value: 2.29e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1034595434  557 AEKDRKLQEKEKQIEELKR-KLEQEQKLV-EVLKMQLE 592
Cdd:pfam09903    3 KEKEKQIKDLQEQIEELKRfKAEQSTKLQgEVLEQHCE 40
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
40-65 1.45e-03

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


:

Pssm-ID: 128947  Cd Length: 26  Bit Score: 37.07  E-value: 1.45e-03
                            10        20
                    ....*....|....*....|....*.
gi 1034595434    40 EVLQLRLQQRRTREQLVDQGIMPPLK 65
Cdd:smart00707    1 DVLNRKLSQRPTREELEERNILKELS 26
PRK10263 super family cl35903
DNA translocase FtsK; Provisional
 598-785 4.92e-03

DNA translocase FtsK; Provisional


The actual alignment was detected with superfamily member PRK10263:

Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.22  E-value: 4.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595434  598 QQQRPLEAQPSAPGHSVKSDQKHGSLGSSIKDEASLPDCSSSRQPIPVAShavgQPVSTGGQTLVAKKAVVIKQEVPvgQ 677
Cdd:PRK10263   707 QQQRYSGEQPAGANPFSLDDFEFSPMKALLDDGPHEPLFTPIVEPVQQPQ----QPVAPQQQYQQPQQPVAPQPQYQ--Q 780

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595434  678 AEQQSVVSQFYTSPQAGMQTQPQIATAAQiptaalasglaPTVPQTQDTFPQHVLSQPQQvrkvftnsassntvlpYQRH 757
Cdd:PRK10263   781 PQQPVAPQPQYQQPQQPVAPQPQYQQPQQ-----------PVAPQPQYQQPQQPVAPQPQ----------------YQQP 833

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1034595434  758 PAPAVQQP--------FINKASNSVLQSRNAPLPSL 785
Cdd:PRK10263   834 QQPVAPQPqdtllhplLMRNGDSRPLHKPTTPLPSL 869
 
Name Accession Description Interval E-value
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 389-422 2.73e-10

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 56.25  E-value: 2.73e-10
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1034595434  389 LDDLKVSELKTELKLRGLPVSGTKPDLIERLKPY 422
Cdd:pfam02037    1 LSKLTVAELKEELRKRGLPTSGKKAELIERLQEY 34
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
389-420 7.22e-09

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 52.10  E-value: 7.22e-09
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1034595434   389 LDDLKVSELKTELKLRGLPVSGTKPDLIERLK 420
Cdd:smart00513    1 LAKLKVSELKDELKKRGLSTSGTKAELVDRLL 32
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
128-153 1.45e-05

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 42.46  E-value: 1.45e-05
                            10        20
                    ....*....|....*....|....*.
gi 1034595434   128 DDLNEKIAQRPGPMELVEKNILPVDS 153
Cdd:smart00707    1 DVLNRKLSQRPTREELEERNILKELS 26
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 129-152 3.41e-05

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 41.49  E-value: 3.41e-05
                           10        20
                   ....*....|....*....|....
gi 1034595434  129 DLNEKIAQRPGPMELVEKNILPVD 152
Cdd:pfam02755    1 SLERKLSHRPTREELVERNILPED 24
PHA03247 PHA03247
large tegument protein UL36; Provisional
 186-399 7.04e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 7.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595434  186 PDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVPEflkTPPTADQP--PPRPAAPVLPTNTV-SSAKPGP 262
Cdd:PHA03247  2784 TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPL---PPPTSAQPtaPPPPPGPPPPSLPLgGSVAPGG 2860

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595434  263 ALVK----QSHPKNPNDKHRSKKCKDPKPRVKKLKYHQYIPPDQKGEKNEPQmdsnyarLLQQQQLFLQLQILSQQKQHY 338
Cdd:PHA03247  2861 DVRRrppsRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQ-------APPPPQPQPQPPPPPQPQPPP 2933

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034595434  339 NYQTILPAPFKPLNDKNSNSG---------NSALNNATPNTPRQNTSTP---VRKPGPLPSSLDDLKVSELKT 399
Cdd:PHA03247  2934 PPPPRPQPPLAPTTDPAGAGEpsgavpqpwLGALVPGRVAVPRFRVPQPapsREAPASSTPPLTGHSLSRVSS 3006
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 85-108 1.81e-04

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 39.56  E-value: 1.81e-04
                           10        20
                   ....*....|....*....|....
gi 1034595434   85 FLKHKIRSRPDRSELVRMHILEET 108
Cdd:pfam02755    1 SLERKLSHRPTREELVERNILPED 24
DUF2130 pfam09903
Uncharacterized protein conserved in bacteria (DUF2130); This domain, found in various ...
 557-592 2.29e-04

Uncharacterized protein conserved in bacteria (DUF2130); This domain, found in various hypothetical prokaryotic proteins, has no known function.


Pssm-ID: 430914 [Multi-domain]  Cd Length: 248  Bit Score: 44.15  E-value: 2.29e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1034595434  557 AEKDRKLQEKEKQIEELKR-KLEQEQKLV-EVLKMQLE 592
Cdd:pfam09903    3 KEKEKQIKDLQEQIEELKRfKAEQSTKLQgEVLEQHCE 40
COG4487 COG4487
Uncharacterized conserved protein, contains DUF2130 domain [Function unknown];
553-592 4.24e-04

Uncharacterized conserved protein, contains DUF2130 domain [Function unknown];


Pssm-ID: 443580 [Multi-domain]  Cd Length: 425  Bit Score: 44.17  E-value: 4.24e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1034595434  553 ELDAAEKDRKLQEKEKQIEELKRKLEQ-EQKLV-EVLKMQLE 592
Cdd:COG4487    167 SLKVAEYEKQLKDMQEQIEELKRKKEQgSTQLQgEVLELEFE 208
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
40-65 1.45e-03

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 37.07  E-value: 1.45e-03
                            10        20
                    ....*....|....*....|....*.
gi 1034595434    40 EVLQLRLQQRRTREQLVDQGIMPPLK 65
Cdd:smart00707    1 DVLNRKLSQRPTREELEERNILKELS 26
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 560-606 2.69e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 41.02  E-value: 2.69e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1034595434  560 DRKLQEKEKQIEELKRK---LEQEQKLVEVLKMQLEvEKRGQQQRPLEAQ 606
Cdd:cd16269    190 DQALTEKEKEIEAERAKaeaAEQERKLLEEQQRELE-QKLEDQERSYEEH 238
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
85-108 3.30e-03

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 35.92  E-value: 3.30e-03
                            10        20
                    ....*....|....*....|....
gi 1034595434    85 FLKHKIRSRPDRSELVRMHILEET 108
Cdd:smart00707    2 VLNRKLSQRPTREELEERNILKEL 25
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 598-785 4.92e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.22  E-value: 4.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595434  598 QQQRPLEAQPSAPGHSVKSDQKHGSLGSSIKDEASLPDCSSSRQPIPVAShavgQPVSTGGQTLVAKKAVVIKQEVPvgQ 677
Cdd:PRK10263   707 QQQRYSGEQPAGANPFSLDDFEFSPMKALLDDGPHEPLFTPIVEPVQQPQ----QPVAPQQQYQQPQQPVAPQPQYQ--Q 780

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595434  678 AEQQSVVSQFYTSPQAGMQTQPQIATAAQiptaalasglaPTVPQTQDTFPQHVLSQPQQvrkvftnsassntvlpYQRH 757
Cdd:PRK10263   781 PQQPVAPQPQYQQPQQPVAPQPQYQQPQQ-----------PVAPQPQYQQPQQPVAPQPQ----------------YQQP 833

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1034595434  758 PAPAVQQP--------FINKASNSVLQSRNAPLPSL 785
Cdd:PRK10263   834 QQPVAPQPqdtllhplLMRNGDSRPLHKPTTPLPSL 869
 
Name Accession Description Interval E-value
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 389-422 2.73e-10

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 56.25  E-value: 2.73e-10
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1034595434  389 LDDLKVSELKTELKLRGLPVSGTKPDLIERLKPY 422
Cdd:pfam02037    1 LSKLTVAELKEELRKRGLPTSGKKAELIERLQEY 34
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
389-420 7.22e-09

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 52.10  E-value: 7.22e-09
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1034595434   389 LDDLKVSELKTELKLRGLPVSGTKPDLIERLK 420
Cdd:smart00513    1 LAKLKVSELKDELKKRGLSTSGTKAELVDRLL 32
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
128-153 1.45e-05

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 42.46  E-value: 1.45e-05
                            10        20
                    ....*....|....*....|....*.
gi 1034595434   128 DDLNEKIAQRPGPMELVEKNILPVDS 153
Cdd:smart00707    1 DVLNRKLSQRPTREELEERNILKELS 26
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 129-152 3.41e-05

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 41.49  E-value: 3.41e-05
                           10        20
                   ....*....|....*....|....
gi 1034595434  129 DLNEKIAQRPGPMELVEKNILPVD 152
Cdd:pfam02755    1 SLERKLSHRPTREELVERNILPED 24
PHA03247 PHA03247
large tegument protein UL36; Provisional
 186-399 7.04e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 7.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595434  186 PDQPASQESQGSAASPSEPKVSESPSPVTTNTPAQFASVSPTVPEflkTPPTADQP--PPRPAAPVLPTNTV-SSAKPGP 262
Cdd:PHA03247  2784 TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPL---PPPTSAQPtaPPPPPGPPPPSLPLgGSVAPGG 2860

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595434  263 ALVK----QSHPKNPNDKHRSKKCKDPKPRVKKLKYHQYIPPDQKGEKNEPQmdsnyarLLQQQQLFLQLQILSQQKQHY 338
Cdd:PHA03247  2861 DVRRrppsRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQ-------APPPPQPQPQPPPPPQPQPPP 2933

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034595434  339 NYQTILPAPFKPLNDKNSNSG---------NSALNNATPNTPRQNTSTP---VRKPGPLPSSLDDLKVSELKT 399
Cdd:PHA03247  2934 PPPPRPQPPLAPTTDPAGAGEpsgavpqpwLGALVPGRVAVPRFRVPQPapsREAPASSTPPLTGHSLSRVSS 3006
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 85-108 1.81e-04

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 39.56  E-value: 1.81e-04
                           10        20
                   ....*....|....*....|....
gi 1034595434   85 FLKHKIRSRPDRSELVRMHILEET 108
Cdd:pfam02755    1 SLERKLSHRPTREELVERNILPED 24
DUF2130 pfam09903
Uncharacterized protein conserved in bacteria (DUF2130); This domain, found in various ...
 557-592 2.29e-04

Uncharacterized protein conserved in bacteria (DUF2130); This domain, found in various hypothetical prokaryotic proteins, has no known function.


Pssm-ID: 430914 [Multi-domain]  Cd Length: 248  Bit Score: 44.15  E-value: 2.29e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1034595434  557 AEKDRKLQEKEKQIEELKR-KLEQEQKLV-EVLKMQLE 592
Cdd:pfam09903    3 KEKEKQIKDLQEQIEELKRfKAEQSTKLQgEVLEQHCE 40
COG4487 COG4487
Uncharacterized conserved protein, contains DUF2130 domain [Function unknown];
553-592 4.24e-04

Uncharacterized conserved protein, contains DUF2130 domain [Function unknown];


Pssm-ID: 443580 [Multi-domain]  Cd Length: 425  Bit Score: 44.17  E-value: 4.24e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1034595434  553 ELDAAEKDRKLQEKEKQIEELKRKLEQ-EQKLV-EVLKMQLE 592
Cdd:COG4487    167 SLKVAEYEKQLKDMQEQIEELKRKKEQgSTQLQgEVLELEFE 208
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
40-65 1.45e-03

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 37.07  E-value: 1.45e-03
                            10        20
                    ....*....|....*....|....*.
gi 1034595434    40 EVLQLRLQQRRTREQLVDQGIMPPLK 65
Cdd:smart00707    1 DVLNRKLSQRPTREELEERNILKELS 26
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
174-312 1.64e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 42.46  E-value: 1.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595434  174 FSFDEDSSDALSPDQPASQESQGSAASPSEP-KVSESPSPVTTNTPAQfASVSPTVPEFLKTPPTADQPPPRPaAPVLPT 252
Cdd:PRK14971   363 TQKGDDASGGRGPKQHIKPVFTQPAAAPQPSaAAAASPSPSQSSAAAQ-PSAPQSATQPAGTPPTVSVDPPAA-VPVNPP 440

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034595434  253 NTVSSAKPGPalVKQSHPKNPNDKHRS-----KKCKDPKPRVKKLKYHQYIPPDQKGEKNEPQMD 312
Cdd:PRK14971   441 STAPQAVRPA--QFKEEKKIPVSKVSSlgpstLRPIQEKAEQATGNIKEAPTGTQKEIFTEEDLQ 503
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 560-606 2.69e-03

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 41.02  E-value: 2.69e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1034595434  560 DRKLQEKEKQIEELKRK---LEQEQKLVEVLKMQLEvEKRGQQQRPLEAQ 606
Cdd:cd16269    190 DQALTEKEKEIEAERAKaeaAEQERKLLEEQQRELE-QKLEDQERSYEEH 238
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
85-108 3.30e-03

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 35.92  E-value: 3.30e-03
                            10        20
                    ....*....|....*....|....
gi 1034595434    85 FLKHKIRSRPDRSELVRMHILEET 108
Cdd:smart00707    2 VLNRKLSQRPTREELEERNILKEL 25
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 598-785 4.92e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.22  E-value: 4.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595434  598 QQQRPLEAQPSAPGHSVKSDQKHGSLGSSIKDEASLPDCSSSRQPIPVAShavgQPVSTGGQTLVAKKAVVIKQEVPvgQ 677
Cdd:PRK10263   707 QQQRYSGEQPAGANPFSLDDFEFSPMKALLDDGPHEPLFTPIVEPVQQPQ----QPVAPQQQYQQPQQPVAPQPQYQ--Q 780

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595434  678 AEQQSVVSQFYTSPQAGMQTQPQIATAAQiptaalasglaPTVPQTQDTFPQHVLSQPQQvrkvftnsassntvlpYQRH 757
Cdd:PRK10263   781 PQQPVAPQPQYQQPQQPVAPQPQYQQPQQ-----------PVAPQPQYQQPQQPVAPQPQ----------------YQQP 833

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1034595434  758 PAPAVQQP--------FINKASNSVLQSRNAPLPSL 785
Cdd:PRK10263   834 QQPVAPQPqdtllhplLMRNGDSRPLHKPTTPLPSL 869
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 182-284 7.22e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.44  E-value: 7.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034595434  182 DALSPDQPASQESQGSAASPSEPKVSESPS-PVTTNTPAqfasvSPTVPEFLKTPPTAdQPPPRPAAPVLPTNTVSSAKP 260
Cdd:PTZ00449   584 DPKHPKDPEEPKKPKRPRSAQRPTRPKSPKlPELLDIPK-----SPKRPESPKSPKRP-PPPQRPSSPERPEGPKIIKSP 657

                           90       100
                   ....*....|....*....|....
gi 1034595434  261 GPAlvkqSHPKNPNDKHRSKKCKD 284
Cdd:PTZ00449   658 KPP----KSPKPPFDPKFKEKFYD 677
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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