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Conserved domains on  [gi|1034607839|ref|XP_016882261|]
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zinc finger protein 568 isoform X2 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
48-102 1.68e-32

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 119.23  E-value: 1.68e-32
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1034607839   48 VTFKDVAVDLTQEEWEQMKPAQRNLYRDVMLENYSNLVTVGCQVTKPDVIFKLEQ 102
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQ 55
KRAB smart00349
krueppel associated box;
137-197 7.77e-31

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 114.61  E-value: 7.77e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034607839  137 LKFKDVVIYFSQKEWECLHSAQKDLYRDVMLENYGNLVLLGLSDTKPNVISLLEQKKEPWM 197
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
278-621 1.40e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 1.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607839 278 LHTGEKSCECRKC---KNAFRYQSCPIQHEIIHNKekepecgecrkifNSGSDLIKHQTLHESKKHSENNKCAFN----- 349
Cdd:COG5048    55 SHTGEKPSQCSYSgcdKSFSRPLELSRHLRTHHNN-------------PSDLNSKSLPLSNSKASSSSLSSSSSNsndnn 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607839 350 HDSGITQPQSINTGEKP----------HKCKECGKAFR----SSSQISQHQRMHLGEKPYKCRECGK------AFPSTAQ 409
Cdd:COG5048   122 LLSSHSLPPSSRDPQLPdllsisnlrnNPLPGNNSSSVntpqSNSLHPPLPANSLSKDPSSNLSLLIssnvstSIPSSSE 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607839 410 LNLHQR---------IHTDEKYYESKACGKAFTRPSHLFRHQR---IHTGEKPHKCKECGKAFRYDTQLSLHQIIHTGER 477
Cdd:COG5048   202 NSPLSSsysipssssDQNLENSSSSLPLTTNSQLSPKSLLSQSpssLSSSDSSSSASESPRSSLPTASSQSSSPNESDSS 281

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607839 478 -------RYECRECGKVYSCASQLSLHQR--IHTGE--KPHECKE--CGKAFISDSHLIRHQSVHTGEKPCKCK--ECGK 542
Cdd:COG5048   282 sekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSS 361

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607839 543 SFRRGSELTRHQRA--HTGEKPYECKECEKAFTCSTELVRHQ-----KVHTGERPH--KCKECGKAFIRRSELTHHERSH 613
Cdd:COG5048   362 KFSPLLNNEPPQSLqqYKDLKNDKKSETLSNSCIRNFKRDSNlslhiITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIH 441


                  ....*...
gi 1034607839 614 TGEKPYEC 621
Cdd:COG5048   442 TNHAPLLC 449
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
48-102 1.68e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 119.23  E-value: 1.68e-32
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1034607839   48 VTFKDVAVDLTQEEWEQMKPAQRNLYRDVMLENYSNLVTVGCQVTKPDVIFKLEQ 102
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQ 55
KRAB smart00349
krueppel associated box;
137-197 7.77e-31

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 114.61  E-value: 7.77e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034607839  137 LKFKDVVIYFSQKEWECLHSAQKDLYRDVMLENYGNLVLLGLSDTKPNVISLLEQKKEPWM 197
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 48-88 2.10e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 92.92  E-value: 2.10e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1034607839  48 VTFKDVAVDLTQEEWEQMKPAQRNLYRDVMLENYSNLVTVG 88
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 139-177 2.93e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.76  E-value: 2.93e-21
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1034607839 139 FKDVVIYFSQKEWECLHSAQKDLYRDVMLENYGNLVLLG 177
Cdd:pfam01352   4 FEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 48-85 7.03e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 82.98  E-value: 7.03e-20
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1034607839  48 VTFKDVAVDLTQEEWEQMKPAQRNLYRDVMLENYSNLV 85
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 137-176 5.16e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.59  E-value: 5.16e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1034607839 137 LKFKDVVIYFSQKEWECLHSAQKDLYRDVMLENYGNLVLL 176
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
278-621 1.40e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 1.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607839 278 LHTGEKSCECRKC---KNAFRYQSCPIQHEIIHNKekepecgecrkifNSGSDLIKHQTLHESKKHSENNKCAFN----- 349
Cdd:COG5048    55 SHTGEKPSQCSYSgcdKSFSRPLELSRHLRTHHNN-------------PSDLNSKSLPLSNSKASSSSLSSSSSNsndnn 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607839 350 HDSGITQPQSINTGEKP----------HKCKECGKAFR----SSSQISQHQRMHLGEKPYKCRECGK------AFPSTAQ 409
Cdd:COG5048   122 LLSSHSLPPSSRDPQLPdllsisnlrnNPLPGNNSSSVntpqSNSLHPPLPANSLSKDPSSNLSLLIssnvstSIPSSSE 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607839 410 LNLHQR---------IHTDEKYYESKACGKAFTRPSHLFRHQR---IHTGEKPHKCKECGKAFRYDTQLSLHQIIHTGER 477
Cdd:COG5048   202 NSPLSSsysipssssDQNLENSSSSLPLTTNSQLSPKSLLSQSpssLSSSDSSSSASESPRSSLPTASSQSSSPNESDSS 281

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607839 478 -------RYECRECGKVYSCASQLSLHQR--IHTGE--KPHECKE--CGKAFISDSHLIRHQSVHTGEKPCKCK--ECGK 542
Cdd:COG5048   282 sekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSS 361

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607839 543 SFRRGSELTRHQRA--HTGEKPYECKECEKAFTCSTELVRHQ-----KVHTGERPH--KCKECGKAFIRRSELTHHERSH 613
Cdd:COG5048   362 KFSPLLNNEPPQSLqqYKDLKNDKKSETLSNSCIRNFKRDSNlslhiITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIH 441


                  ....*...
gi 1034607839 614 TGEKPYEC 621
Cdd:COG5048   442 TNHAPLLC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
437-462 4.40e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 4.40e-05
                          10        20
                  ....*....|....*....|....*.
gi 1034607839 437 HLFRHQRIHTGEKPHKCKECGKAFRY 462
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
48-102 1.68e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 119.23  E-value: 1.68e-32
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1034607839   48 VTFKDVAVDLTQEEWEQMKPAQRNLYRDVMLENYSNLVTVGCQVTKPDVIFKLEQ 102
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQ 55
KRAB smart00349
krueppel associated box;
137-197 7.77e-31

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 114.61  E-value: 7.77e-31
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034607839  137 LKFKDVVIYFSQKEWECLHSAQKDLYRDVMLENYGNLVLLGLSDTKPNVISLLEQKKEPWM 197
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 48-88 2.10e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 92.92  E-value: 2.10e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1034607839  48 VTFKDVAVDLTQEEWEQMKPAQRNLYRDVMLENYSNLVTVG 88
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 139-177 2.93e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.76  E-value: 2.93e-21
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1034607839 139 FKDVVIYFSQKEWECLHSAQKDLYRDVMLENYGNLVLLG 177
Cdd:pfam01352   4 FEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 48-85 7.03e-20

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 82.98  E-value: 7.03e-20
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1034607839  48 VTFKDVAVDLTQEEWEQMKPAQRNLYRDVMLENYSNLV 85
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 137-176 5.16e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.59  E-value: 5.16e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1034607839 137 LKFKDVVIYFSQKEWECLHSAQKDLYRDVMLENYGNLVLL 176
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
278-621 1.40e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 1.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607839 278 LHTGEKSCECRKC---KNAFRYQSCPIQHEIIHNKekepecgecrkifNSGSDLIKHQTLHESKKHSENNKCAFN----- 349
Cdd:COG5048    55 SHTGEKPSQCSYSgcdKSFSRPLELSRHLRTHHNN-------------PSDLNSKSLPLSNSKASSSSLSSSSSNsndnn 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607839 350 HDSGITQPQSINTGEKP----------HKCKECGKAFR----SSSQISQHQRMHLGEKPYKCRECGK------AFPSTAQ 409
Cdd:COG5048   122 LLSSHSLPPSSRDPQLPdllsisnlrnNPLPGNNSSSVntpqSNSLHPPLPANSLSKDPSSNLSLLIssnvstSIPSSSE 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607839 410 LNLHQR---------IHTDEKYYESKACGKAFTRPSHLFRHQR---IHTGEKPHKCKECGKAFRYDTQLSLHQIIHTGER 477
Cdd:COG5048   202 NSPLSSsysipssssDQNLENSSSSLPLTTNSQLSPKSLLSQSpssLSSSDSSSSASESPRSSLPTASSQSSSPNESDSS 281

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607839 478 -------RYECRECGKVYSCASQLSLHQR--IHTGE--KPHECKE--CGKAFISDSHLIRHQSVHTGEKPCKCK--ECGK 542
Cdd:COG5048   282 sekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSS 361

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607839 543 SFRRGSELTRHQRA--HTGEKPYECKECEKAFTCSTELVRHQ-----KVHTGERPH--KCKECGKAFIRRSELTHHERSH 613
Cdd:COG5048   362 KFSPLLNNEPPQSLqqYKDLKNDKKSETLSNSCIRNFKRDSNlslhiITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIH 441


                  ....*...
gi 1034607839 614 TGEKPYEC 621
Cdd:COG5048   442 TNHAPLLC 449
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
319-610 8.91e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 8.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607839 319 RKIFNSGSDLIKHQTLHESKKHSENNKCAFNHDSGITQPQSINTGEKPHKCKEcgkafRSSSQISQHQRMHLGEKPYKCR 398
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQ-----SPSSLSSSDSSSSASESPRSSL 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607839 399 eCGKAFPSTAQLNLHQRIHTDEKY-YESKACGKAFTRPSHLFRHQR--IHTGE--KPHKCKE--CGKAFRYDTQLSLHQI 471
Cdd:COG5048   266 -PTASSQSSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607839 472 IHTGERRYECREC-------GKVYSCASQLSLHQRIHTGEKPHEC--KECGKAFISDSHLIRHQSVHTGEKPCKCKecgk 542
Cdd:COG5048   345 LHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCK---- 420

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034607839 543 sfrrgseltrhqrahtgekpyeCKECEKAFTCSTELVRHQKVHTGERPHKCKECGKAFIRRSELTHHE 610
Cdd:COG5048   421 ----------------------NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
437-462 4.40e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 4.40e-05
                          10        20
                  ....*....|....*....|....*.
gi 1034607839 437 HLFRHQRIHTGEKPHKCKECGKAFRY 462
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
505-565 1.15e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 1.15e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034607839 505 KPHECKECGKAFISDSHLIRHQSVHTGEKPCKC--KECGKSFRRGSELTRHQRAHTGEKPYEC 565
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN 94
zf-H2C2_2 pfam13465
Zinc-finger double domain;
577-602 3.52e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.52e-04
                          10        20
                  ....*....|....*....|....*.
gi 1034607839 577 ELVRHQKVHTGERPHKCKECGKAFIR 602
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
494-518 7.49e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.49e-04
                          10        20
                  ....*....|....*....|....*
gi 1034607839 494 LSLHQRIHTGEKPHECKECGKAFIS 518
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
549-574 1.26e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.26e-03
                          10        20
                  ....*....|....*....|....*.
gi 1034607839 549 ELTRHQRAHTGEKPYECKECEKAFTC 574
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
384-404 3.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.30e-03
                          10        20
                  ....*....|....*....|.
gi 1034607839 384 QHQRMHLGEKPYKCRECGKAF 404
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
428-470 3.94e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 3.94e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1034607839 428 CGKAFTRPSHLFRHQRIHTGEKPHKCKECGKAFRYDTQLSLHQ 470
Cdd:COG5048    39 CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSR 81
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
393-622 4.81e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 4.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607839 393 KPYKCRECGKAFPSTAQLNLHQRIHTDEKYYESKA--CGKAFTRPSHLFRHQRIHTGEKPHKCK---------------- 454
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607839 455 ECGKAFRYDTQLSLH--------QIIHTGERRYECREC---------------------------GKVYSCASQLSLHQR 499
Cdd:COG5048   112 SSSSNSNDNNLLSSHslppssrdPQLPDLLSISNLRNNplpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607839 500 IHTGEKPHECKECGKAFISDSHLI----------------------------RHQSVHTGEKPCKCKECGKSFR--RGSE 549
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSsdqnlensssslplttnsqlspksllsqSPSSLSSSDSSSSASESPRSSLptASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034607839 550 LTRHQRAHTGE-----KPYECKECEKAFTCSTELVRHQ--KVHTGE--RPHKCKE--CGKAFIRRSELTHHERSHTGEKP 618
Cdd:COG5048   272 SSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351


                  ....
gi 1034607839 619 YECK 622
Cdd:COG5048   352 AKEK 355
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 591-613 6.21e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 6.21e-03
                          10        20
                  ....*....|....*....|...
gi 1034607839 591 HKCKECGKAFIRRSELTHHERSH 613
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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