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Conserved domains on  [gi|1039779695|ref|XP_017167738|]
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tetratricopeptide repeat protein 23 isoform X6 [Mus musculus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 12138572)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR_12 pfam13424
Tetratricopeptide repeat;
159-225 2.08e-05

Tetratricopeptide repeat;


:

Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 42.37  E-value: 2.08e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039779695 159 RIKLSFAQLYQGQKRSKEAFPFYQKALEYTEITKDEKSLECVQVLRELAGVEQALGLYAAAISHFSR 225
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLER 70
TPR super family cl33886
Tetratricopeptide (TPR) repeat [General function prediction only];
28-271 4.14e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


The actual alignment was detected with superfamily member COG0457:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.00  E-value: 4.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779695  28 YKLYKYKQAIQELVRCVALTRicygdwhwKLAEAYVNLAQGYLQLKGLSlQAKQHAEKAKEILANSIESpchnktdifkc 107
Cdd:COG0457    19 RRLGRYEEAIEDYEKALELDP--------DDAEALYNLGLAYLRLGRYE-EALADYEQALELDPDDAEA----------- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779695 108 slelFYTLGRALLSLQKFKDASENLIKAERLSKEmlqcgnivkeewieiQSRIKLSFAQLYQGQKRSKEAFPFYQKALEY 187
Cdd:COG0457    79 ----LNNLGLALQALGRYEEALEDYDKALELDPD---------------DAEALYNLGLALLELGRYDEAIEAYERALEL 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779695 188 teitkdekSLECVQVLRELAGVEQALGLYAAAISHFSRKPRQVCAGLHSLLPTASGWKLWTAHITRMTQAHLIILSKDPS 267
Cdd:COG0457   140 --------DPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKL 211


                  ....
gi 1039779695 268 PEEA 271
Cdd:COG0457   212 AILT 215
 
Name Accession Description Interval E-value
TPR_12 pfam13424
Tetratricopeptide repeat;
159-225 2.08e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 42.37  E-value: 2.08e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039779695 159 RIKLSFAQLYQGQKRSKEAFPFYQKALEYTEITKDEKSLECVQVLRELAGVEQALGLYAAAISHFSR 225
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLER 70
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
28-271 4.14e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.00  E-value: 4.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779695  28 YKLYKYKQAIQELVRCVALTRicygdwhwKLAEAYVNLAQGYLQLKGLSlQAKQHAEKAKEILANSIESpchnktdifkc 107
Cdd:COG0457    19 RRLGRYEEAIEDYEKALELDP--------DDAEALYNLGLAYLRLGRYE-EALADYEQALELDPDDAEA----------- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779695 108 slelFYTLGRALLSLQKFKDASENLIKAERLSKEmlqcgnivkeewieiQSRIKLSFAQLYQGQKRSKEAFPFYQKALEY 187
Cdd:COG0457    79 ----LNNLGLALQALGRYEEALEDYDKALELDPD---------------DAEALYNLGLALLELGRYDEAIEAYERALEL 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779695 188 teitkdekSLECVQVLRELAGVEQALGLYAAAISHFSRKPRQVCAGLHSLLPTASGWKLWTAHITRMTQAHLIILSKDPS 267
Cdd:COG0457   140 --------DPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKL 211


                  ....
gi 1039779695 268 PEEA 271
Cdd:COG0457   212 AILT 215
 
Name Accession Description Interval E-value
TPR_12 pfam13424
Tetratricopeptide repeat;
159-225 2.08e-05

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 42.37  E-value: 2.08e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039779695 159 RIKLSFAQLYQGQKRSKEAFPFYQKALEYTEITKDEKSLECVQVLRELAGVEQALGLYAAAISHFSR 225
Cdd:pfam13424   4 TALNNLAAVLRRLGRYDEALELLEKALEIARRLLGPDHPLTATTLLNLGRLYLELGRYEEALELLER 70
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
28-271 4.14e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 45.00  E-value: 4.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779695  28 YKLYKYKQAIQELVRCVALTRicygdwhwKLAEAYVNLAQGYLQLKGLSlQAKQHAEKAKEILANSIESpchnktdifkc 107
Cdd:COG0457    19 RRLGRYEEAIEDYEKALELDP--------DDAEALYNLGLAYLRLGRYE-EALADYEQALELDPDDAEA----------- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779695 108 slelFYTLGRALLSLQKFKDASENLIKAERLSKEmlqcgnivkeewieiQSRIKLSFAQLYQGQKRSKEAFPFYQKALEY 187
Cdd:COG0457    79 ----LNNLGLALQALGRYEEALEDYDKALELDPD---------------DAEALYNLGLALLELGRYDEAIEAYERALEL 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779695 188 teitkdekSLECVQVLRELAGVEQALGLYAAAISHFSRKPRQVCAGLHSLLPTASGWKLWTAHITRMTQAHLIILSKDPS 267
Cdd:COG0457   140 --------DPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKL 211


                  ....
gi 1039779695 268 PEEA 271
Cdd:COG0457   212 AILT 215
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 59-229 7.26e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.33  E-value: 7.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779695  59 AEAYVNLAQGYLQLKglslqakqHAEKAKEILANSIESPCHNktdifkcsLELFYTLGRALLSLQKFKDASENLIKAERL 138
Cdd:COG2956    76 AEALLELAQDYLKAG--------LLDRAEELLEKLLELDPDD--------AEALRLLAEIYEQEGDWEKAIEVLERLLKL 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779695 139 SKEmlqcgnivkeewieiQSRIKLSFAQLYQGQKRSKEAFPFYQKALEYTEitkdekslECVQVLRELAGVEQALGLYAA 218
Cdd:COG2956   140 GPE---------------NAHAYCELAELYLEQGDYDEAIEALEKALKLDP--------DCARALLLLAELYLEQGDYEE 196

                         170
                  ....*....|.
gi 1039779695 219 AISHFSRKPRQ 229
Cdd:COG2956   197 AIAALERALEQ 207
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
57-225 1.56e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.07  E-value: 1.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779695  57 KLAEAYVNLAQGYLQLkGLSLQAKQHAEKAKEILANSIESpchnktdifkcslelFYTLGRALLSLQKFKDASENLIKAE 136
Cdd:COG0457     6 DDAEAYNNLGLAYRRL-GRYEEAIEDYEKALELDPDDAEA---------------LYNLGLAYLRLGRYEEALADYEQAL 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779695 137 RLSKEMLQCgnivkeeWIEIqsriklsfAQLYQGQKRSKEAFPFYQKALEYteitkdekSLECVQVLRELAGVEQALGLY 216
Cdd:COG0457    70 ELDPDDAEA-------LNNL--------GLALQALGRYEEALEDYDKALEL--------DPDDAEALYNLGLALLELGRY 126


                  ....*....
gi 1039779695 217 AAAISHFSR 225
Cdd:COG0457   127 DEAIEAYER 135
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 108-253 1.11e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 38.83  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779695 108 SLELFYTLGRALLSLQKFKDASENLIKAERLSKEmlqcgnivkeewieiQSRIKLSFAQLYQGQKRSKEAFPFYQKALEy 187
Cdd:COG4235    16 DAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPD---------------NADALLDLAEALLAAGDTEEAEELLERALA- 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039779695 188 teitKDEKSlecVQVLRELAGVEQALGLYAAAISHFSRkprqvcagLHSLLPTASGWKLWTAHITR 253
Cdd:COG4235    80 ----LDPDN---PEALYLLGLAAFQQGDYAEAIAAWQK--------LLALLPADAPARLLEASIAE 130
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 112-388 1.63e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.10  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779695 112 FYTLGRALLSLQKFKDASENLIKAERLSKEMLQcgnivkeewieiqsrIKLSFAQLYQGQKRSKEAFPFYQKALEyteit 191
Cdd:COG2956    11 WYFKGLNYLLNGQPDKAIDLLEEALELDPETVE---------------AHLALGNLYRRRGEYDRAIRIHQKLLE----- 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779695 192 KDEKSLecvQVLRELAGVEQALGLYAAAISHFSRkprqvcagLHSLLPTASGWKLWTAHI---TRMTQAHLIILSKdpSP 268
Cdd:COG2956    71 RDPDRA---EALLELAQDYLKAGLLDRAEELLEK--------LLELDPDDAEALRLLAEIyeqEGDWEKAIEVLER--LL 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779695 269 EEAADSAHFIARAAAASGMHDHRDVAEKYFQEsmtSIKDSEGAERAKFLSIQdefcsFLQTTGQKERAAMILRESLEAkv 348
Cdd:COG2956   138 KLGPENAHAYCELAELYLEQGDYDEAIEALEK---ALKLDPDCARALLLLAE-----LYLEQGDYEEAIAALERALEQ-- 207

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1039779695 349 gafgdfSPEVAETYRALGRADLAQGNNSGAYAKLKKCVQI 388
Cdd:COG2956   208 ------DPDYLPALPRLAELYEKLGDPEEALELLRKALEL 241
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 59-186 1.99e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 40.75  E-value: 1.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779695  59 AEAYVNLAQGYLQLkGLSLQAKQHAEKAKEIlansieSPCHnktdifkcsLELFYTLGRALLSLQKFKDASENLIKAERL 138
Cdd:COG3914   112 AEALFNLGNLLLAL-GRLEEALAALRRALAL------NPDF---------AEAYLNLGEALRRLGRLEEAIAALRRALEL 175

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1039779695 139 SKEMlqcgnivkeewIEIQSRIklsfAQLYQGQKRSKEAFPFYQKALE 186
Cdd:COG3914   176 DPDN-----------AEALNNL----GNALQDLGRLEEAIAAYRRALE 208
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 32-220 4.92e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.56  E-value: 4.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779695  32 KYKQAIQELVRCVALTRicygdwhwKLAEAYVNLAQGYLQLKGLSlQAKQHAEKAKEILANSIESpchnktdifkcslel 111
Cdd:COG2956   125 DWEKAIEVLERLLKLGP--------ENAHAYCELAELYLEQGDYD-EAIEALEKALKLDPDCARA--------------- 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779695 112 FYTLGRALLSLQKFKDASENLIKAERLSKEMLQcgnivkeewieiqsrIKLSFAQLYQGQKRSKEAFPFYQKALEytEIT 191
Cdd:COG2956   181 LLLLAELYLEQGDYEEAIAALERALEQDPDYLP---------------ALPRLAELYEKLGDPEEALELLRKALE--LDP 243

                         170       180
                  ....*....|....*....|....*....
gi 1039779695 192 KDEKSLECVQVLRELAGVEQALGLYAAAI 220
Cdd:COG2956   244 SDDLLLALADLLERKEGLEAALALLERQL 272
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 69-225 9.21e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 36.32  E-value: 9.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779695  69 YLQLKGLSLQAKQHAEKAKEILANSIEspchnktdIFKCSLELFYTLGRALLSLQKFKDASENLIKAERLSKEmlqcgni 148
Cdd:COG4783     6 ALYALAQALLLAGDYDEAEALLEKALE--------LDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPD------- 70

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039779695 149 vkeewieiQSRIKLSFAQLYQGQKRSKEAFPFYQKALEYTEitkdekslECVQVLRELAGVEQALGLYAAAISHFSR 225
Cdd:COG4783    71 --------EPEARLNLGLALLKAGDYDEALALLEKALKLDP--------EHPEAYLRLARAYRALGRPDEAIAALEK 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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