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Conserved domains on  [gi|1039792727|ref|XP_017168770|]
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trophoblast glycoprotein isoform X1 [Mus musculus]

Protein Classification

LRRNT and LRR domain-containing protein( domain architecture ID 12183445)

protein containing domains LRRNT, LRR, and LRRCT

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
94-301 1.66e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.83  E-value: 1.66e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727  94 RNLFLTGNQMTVLPAgAFARqppLADLEALNLSGNHLKEVCAgAFEHLPGLRRLDLSHNPLTNLSAFAFAGSNasvsaps 173
Cdd:COG4886   116 ESLDLSGNQLTDLPE-ELAN---LTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNLTN------- 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727 174 pLEELIL--NHIvppedqrqngsfegmvafegmvaAALRSGLA-LRGLTRLELASNHFLFLPRDLlAQLPSLRYLDLRNN 250
Cdd:COG4886   184 -LKELDLsnNQI-----------------------TDLPEPLGnLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNN 238

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1039792727 251 SLVSLtyASFRNLTHLESLHLEDNALKVLhnSTLAEWHGLAHVKvfLDNNP 301
Cdd:COG4886   239 QLTDL--PELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLD--LSNNQ 283
LRRCT smart00082
Leucine rich repeat C-terminal domain;
300-351 1.03e-11

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 59.37  E-value: 1.03e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039792727  300 NPWVCDCYMADMVAWLKETEVVPDKARLTCAFPEKMRNRgLLDLNSSDLDCD 351
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
LRRNT smart00013
Leucine rich repeat N-terminal domain;
62-95 4.14e-05

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.38  E-value: 4.14e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1039792727   62 CPAACECSeaARTVKCVNRNLLEVPADLPPYVRN 95
Cdd:smart00013   2 CPAPCNCS--GTAVDCSGRGLTEVPLDLPPDTTL 33
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
94-301 1.66e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.83  E-value: 1.66e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727  94 RNLFLTGNQMTVLPAgAFARqppLADLEALNLSGNHLKEVCAgAFEHLPGLRRLDLSHNPLTNLSAFAFAGSNasvsaps 173
Cdd:COG4886   116 ESLDLSGNQLTDLPE-ELAN---LTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNLTN------- 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727 174 pLEELIL--NHIvppedqrqngsfegmvafegmvaAALRSGLA-LRGLTRLELASNHFLFLPRDLlAQLPSLRYLDLRNN 250
Cdd:COG4886   184 -LKELDLsnNQI-----------------------TDLPEPLGnLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNN 238

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1039792727 251 SLVSLtyASFRNLTHLESLHLEDNALKVLhnSTLAEWHGLAHVKvfLDNNP 301
Cdd:COG4886   239 QLTDL--PELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLD--LSNNQ 283
LRRCT smart00082
Leucine rich repeat C-terminal domain;
300-351 1.03e-11

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 59.37  E-value: 1.03e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039792727  300 NPWVCDCYMADMVAWLKETEVVPDKARLTCAFPEKMRNRgLLDLNSSDLDCD 351
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
LRR_8 pfam13855
Leucine rich repeat;
216-276 1.98e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.08  E-value: 1.98e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039792727 216 RGLTRLELASNHFLFLPRDLLAQLPSLRYLDLRNNSLVSLTYASFRNLTHLESLHLEDNAL 276
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 75-304 4.03e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.41  E-value: 4.03e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727  75 VKCVNRNLLEVPA-DLPPYVRNLFLTGNQMTVLPAGAFARQppladLEALNLSGNHLKEVCAgaFEHLPGLRRLDLSHNP 153
Cdd:cd21340     7 LYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIENLEFLTN-----LTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727 154 LTNLSAFafagsnasvSAPSPLEELilnHIvppEDQRqngsfegmvafegmvaaaLRSGLALrgltrlelasnhfLFLPR 233
Cdd:cd21340    80 ISVVEGL---------ENLTNLEEL---HI---ENQR------------------LPPGEKL-------------TFDPR 113

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039792727 234 DLLAQLPSLRYLDLRNNSLVSLTyaSFRNLTHLESLHLEDNALKVLHN--STLAEWHGLAHVKvfLDNNPwVC 304
Cdd:cd21340   114 SLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELD--LTGNP-VC 181
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
79-279 3.10e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 49.70  E-value: 3.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727  79 NRNLLEVPADLPPYVRNLFLTGNQMTVLPAgafarqpPLAD-LEALNLSGNHLKEVCagafEHLP-GLRRLDLSHNPLTN 156
Cdd:PRK15370  208 NNELKSLPENLQGNIKTLYANSNQLTSIPA-------TLPDtIQEMELSINRITELP----ERLPsALQSLDLFHNKISC 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727 157 LsafafagsnasvsaPSPLeelilnhivpPEDQRQNGSFEGMVAfegMVAAALRSglalrGLTRLELASNHFLFLPRDLl 236
Cdd:PRK15370  277 L--------------PENL----------PEELRYLSVYDNSIR---TLPAHLPS-----GITHLNVQSNSLTALPETL- 323

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1039792727 237 aqLPSLRYLDLRNNSLVSLTyASFRnlTHLESLHLEDNALKVL 279
Cdd:PRK15370  324 --PPGLKTLEAGENALTSLP-ASLP--PELQVLDVSKNQITVL 361
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 271-357 1.39e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 47.77  E-value: 1.39e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727  271 LEDNALKVLHNSTLAEWHGLAHVKvfLDNNPWVCDCYMADMVAWLKETEV-VPDKARLTCAFPEKMRNRGLLDLNSSDLD 349
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEID--LSGNPFECDCGLARLPRWAEEKGVkVRQPEAALCAGPGALAGQPLLGIPLLDSG 79

                           90
                   ....*....|..
gi 1039792727  350 CD----AVLPQS 357
Cdd:TIGR00864   80 CDeeyvACLKDN 91
LRRNT smart00013
Leucine rich repeat N-terminal domain;
62-95 4.14e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.38  E-value: 4.14e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1039792727   62 CPAACECSeaARTVKCVNRNLLEVPADLPPYVRN 95
Cdd:smart00013   2 CPAPCNCS--GTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 62-90 5.01e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.22  E-value: 5.01e-04
                          10        20
                  ....*....|....*....|....*....
gi 1039792727  62 CPAACECSeaARTVKCVNRNLLEVPADLP 90
Cdd:pfam01462   2 CPVPCHCS--ATVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
94-301 1.66e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.83  E-value: 1.66e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727  94 RNLFLTGNQMTVLPAgAFARqppLADLEALNLSGNHLKEVCAgAFEHLPGLRRLDLSHNPLTNLSAFAFAGSNasvsaps 173
Cdd:COG4886   116 ESLDLSGNQLTDLPE-ELAN---LTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELGNLTN------- 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727 174 pLEELIL--NHIvppedqrqngsfegmvafegmvaAALRSGLA-LRGLTRLELASNHFLFLPRDLlAQLPSLRYLDLRNN 250
Cdd:COG4886   184 -LKELDLsnNQI-----------------------TDLPEPLGnLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNN 238

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1039792727 251 SLVSLtyASFRNLTHLESLHLEDNALKVLhnSTLAEWHGLAHVKvfLDNNP 301
Cdd:COG4886   239 QLTDL--PELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLD--LSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-290 3.21e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.06  E-value: 3.21e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727  79 NRNLLEVPADLP--PYVRNLFLTGNQMTVLPAgAFARqppLADLEALNLSGNHLKEVCAgAFEHLPGLRRLDLSHNPLTN 156
Cdd:COG4886   122 GNQLTDLPEELAnlTNLKELDLSNNQLTDLPE-PLGN---LTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITD 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727 157 LSafafagsnASVSAPSPLEELIL--NHIvppedqrqngsfegmvafegmvaAALRSGLA-LRGLTRLELASNHFLFLPR 233
Cdd:COG4886   197 LP--------EPLGNLTNLEELDLsgNQL-----------------------TDLPEPLAnLTNLETLDLSNNQLTDLPE 245

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039792727 234 dlLAQLPSLRYLDLRNNSLVSLTyaSFRNLTHLESLHLEDNALKVLHNSTLAEWHGL 290
Cdd:COG4886   246 --LGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGL 298
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
117-300 2.58e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.04  E-value: 2.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727 117 LADLEALNLSGNHLKEVCAgAFEHLPGLRRLDLSHNPLTNLsafafagsnasvsaPSPLEELilnhivppedqrqngsfe 196
Cdd:COG4886   112 LTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL--------------PEPLGNL------------------ 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727 197 gmvafegmvaaalrsglalRGLTRLELASNHFLFLPRDLlAQLPSLRYLDLRNNSLVSLTyASFRNLTHLESLHLEDNAL 276
Cdd:COG4886   159 -------------------TNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQL 217

                         170       180
                  ....*....|....*....|....
gi 1039792727 277 KVLhNSTLAEWHGLAHvkVFLDNN 300
Cdd:COG4886   218 TDL-PEPLANLTNLET--LDLSNN 238
LRRCT smart00082
Leucine rich repeat C-terminal domain;
300-351 1.03e-11

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 59.37  E-value: 1.03e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039792727  300 NPWVCDCYMADMVAWLKETEVVPDKARLTCAFPEKMRNRgLLDLNSSDLDCD 351
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
LRR_8 pfam13855
Leucine rich repeat;
216-276 1.98e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.08  E-value: 1.98e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039792727 216 RGLTRLELASNHFLFLPRDLLAQLPSLRYLDLRNNSLVSLTYASFRNLTHLESLHLEDNAL 276
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
91-154 3.50e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.30  E-value: 3.50e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039792727  91 PYVRNLFLTGNQMTVLPAGAFARqppLADLEALNLSGNHLKEVCAGAFEHLPGLRRLDLSHNPL 154
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKG---LSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 75-304 4.03e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 59.41  E-value: 4.03e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727  75 VKCVNRNLLEVPA-DLPPYVRNLFLTGNQMTVLPAGAFARQppladLEALNLSGNHLKEVCAgaFEHLPGLRRLDLSHNP 153
Cdd:cd21340     7 LYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIENLEFLTN-----LTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNR 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727 154 LTNLSAFafagsnasvSAPSPLEELilnHIvppEDQRqngsfegmvafegmvaaaLRSGLALrgltrlelasnhfLFLPR 233
Cdd:cd21340    80 ISVVEGL---------ENLTNLEEL---HI---ENQR------------------LPPGEKL-------------TFDPR 113

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039792727 234 DLLAQLPSLRYLDLRNNSLVSLTyaSFRNLTHLESLHLEDNALKVLHN--STLAEWHGLAHVKvfLDNNPwVC 304
Cdd:cd21340   114 SLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELD--LTGNP-VC 181
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
79-300 7.43e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.33  E-value: 7.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727  79 NRNLLEVPADLPPYVRNLFLTGNQMTVLPAGAFARQPPLADLEALNLSGNhlkevcaGAFEHLPGLRRLDLSHNPLTNLs 158
Cdd:COG4886    57 LRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL- 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727 159 afafagsnasvsaPSPLEELilnhivppedqrqngsfegmvafegmvaaalrsglalRGLTRLELASNHFLFLPRDLlAQ 238
Cdd:COG4886   129 -------------PEELANL-------------------------------------TNLKELDLSNNQLTDLPEPL-GN 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039792727 239 LPSLRYLDLRNNSLVSLTyASFRNLTHLESLHLEDNALKVLHNStLAEWHGLahVKVFLDNN 300
Cdd:COG4886   158 LTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPEP-LGNLTNL--EELDLSGN 215
LRR_8 pfam13855
Leucine rich repeat;
120-182 6.83e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 6.83e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039792727 120 LEALNLSGNHLKEVCAGAFEHLPGLRRLDLSHNPLTNLSAFAFAGSNAsvsapspLEELILNH 182
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPS-------LRYLDLSG 58
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
94-279 8.77e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.25  E-value: 8.77e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727  94 RNLFLTGNQMTVLPAgAFARqppLADLEALNLSGNHLKEVcAGAFEHLPGLRRLDLSHNPLTNLSAFAfagsnasvsaps 173
Cdd:COG4886   185 KELDLSNNQITDLPE-PLGN---LTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPELG------------ 247

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727 174 pleelilnhivppedqrqngsfegmvafegmvaaalrsglALRGLTRLELASNHFLFLPrdLLAQLPSLRYLDLRNNSLV 253
Cdd:COG4886   248 ----------------------------------------NLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLT 285

                         170       180
                  ....*....|....*....|....*.
gi 1039792727 254 SLTYASFRNLTHLESLHLEDNALKVL 279
Cdd:COG4886   286 DLKLKELELLLGLNSLLLLLLLLNLL 311
LRR_8 pfam13855
Leucine rich repeat;
240-301 3.50e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 3.50e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039792727 240 PSLRYLDLRNNSLVSLTYASFRNLTHLESLHLEDNALKVLHNSTLaewHGLAHVKV-FLDNNP 301
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAF---SGLPSLRYlDLSGNR 60
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
79-279 3.10e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 49.70  E-value: 3.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727  79 NRNLLEVPADLPPYVRNLFLTGNQMTVLPAgafarqpPLAD-LEALNLSGNHLKEVCagafEHLP-GLRRLDLSHNPLTN 156
Cdd:PRK15370  208 NNELKSLPENLQGNIKTLYANSNQLTSIPA-------TLPDtIQEMELSINRITELP----ERLPsALQSLDLFHNKISC 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727 157 LsafafagsnasvsaPSPLeelilnhivpPEDQRQNGSFEGMVAfegMVAAALRSglalrGLTRLELASNHFLFLPRDLl 236
Cdd:PRK15370  277 L--------------PENL----------PEELRYLSVYDNSIR---TLPAHLPS-----GITHLNVQSNSLTALPETL- 323

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1039792727 237 aqLPSLRYLDLRNNSLVSLTyASFRnlTHLESLHLEDNALKVL 279
Cdd:PRK15370  324 --PPGLKTLEAGENALTSLP-ASLP--PELQVLDVSKNQITVL 361
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 119-276 3.88e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.51  E-value: 3.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727 119 DLEALNLSGNHLKE------VCAGAFEHLPGLRRLDLSHNPLTNLSAFAFagsnASVSAPSPLEELILNhivppedqrqN 192
Cdd:cd00116    52 SLKELCLSLNETGRiprglqSLLQGLTKGCGLQELDLSDNALGPDGCGVL----ESLLRSSSLQELKLN----------N 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727 193 GSFEGMVafEGMVAAALRS-GLALRGL----TRLELASNHFLflpRDLLAQLPSLRYLDLRNNSL----VSLTYASFRNL 263
Cdd:cd00116   118 NGLGDRG--LRLLAKGLKDlPPALEKLvlgrNRLEGASCEAL---AKALRANRDLKELNLANNGIgdagIRALAEGLKAN 192

                         170
                  ....*....|...
gi 1039792727 264 THLESLHLEDNAL 276
Cdd:cd00116   193 CNLEVLDLNNNGL 205
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 271-357 1.39e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 47.77  E-value: 1.39e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727  271 LEDNALKVLHNSTLAEWHGLAHVKvfLDNNPWVCDCYMADMVAWLKETEV-VPDKARLTCAFPEKMRNRGLLDLNSSDLD 349
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEID--LSGNPFECDCGLARLPRWAEEKGVkVRQPEAALCAGPGALAGQPLLGIPLLDSG 79

                           90
                   ....*....|..
gi 1039792727  350 CD----AVLPQS 357
Cdd:TIGR00864   80 CDeeyvACLKDN 91
LRRNT smart00013
Leucine rich repeat N-terminal domain;
62-95 4.14e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.38  E-value: 4.14e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1039792727   62 CPAACECSeaARTVKCVNRNLLEVPADLPPYVRN 95
Cdd:smart00013   2 CPAPCNCS--GTAVDCSGRGLTEVPLDLPPDTTL 33
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 122-276 1.01e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727 122 ALNLSGNHLKEVCAGAFEHLPGLRRLDLSHNPLT-----------------NLSAFAFAGSNASVSAPSpLEELIL-NHI 183
Cdd:PLN00113   73 SIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSgpipddifttssslrylNLSNNNFTGSIPRGSIPN-LETLDLsNNM 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727 184 VPPEDQRQNGSFEGMVAFE-GMVAAALRSGLALRGLTRLE---LASNHFLF-LPRDL----------------------- 235
Cdd:PLN00113  152 LSGEIPNDIGSFSSLKVLDlGGNVLVGKIPNSLTNLTSLEfltLASNQLVGqIPRELgqmkslkwiylgynnlsgeipye 231

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1039792727 236 LAQLPSLRYLDLRNNSLVSLTYASFRNLTHLESLHLEDNAL 276
Cdd:PLN00113  232 IGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKL 272
LRR_8 pfam13855
Leucine rich repeat;
142-252 1.72e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727 142 PGLRRLDLSHNPLTNLSAFAFAGsnasvsapspleelilnhivppedqrqngsfegmvafegmvaaalrsglaLRGLTRL 221
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKG--------------------------------------------------LSNLKVL 30

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1039792727 222 ELASNHFLFLPRDLLAQLPSLRYLDLRNNSL 252
Cdd:pfam13855  31 DLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 240-274 3.86e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.00  E-value: 3.86e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1039792727 240 PSLRYLDLRNNSLVSLtyASFRNLTHLESLHLEDN 274
Cdd:pfam12799   1 PNLEVLDLSNNQITDI--PPLAKLPNLETLDLSGN 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 62-90 5.01e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.22  E-value: 5.01e-04
                          10        20
                  ....*....|....*....|....*....
gi 1039792727  62 CPAACECSeaARTVKCVNRNLLEVPADLP 90
Cdd:pfam01462   2 CPVPCHCS--ATVVNCSDRGLTAVPRDLP 28
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 120-161 7.54e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 7.54e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1039792727 120 LEALNLSGNHLKEVcaGAFEHLPGLRRLDLSHN-PLTNLSAFA 161
Cdd:pfam12799   3 LEVLDLSNNQITDI--PPLAKLPNLETLDLSGNnKITDLSDLA 43
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 98-252 1.42e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.42  E-value: 1.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727  98 LTGNQMTVLPAgaFARQPPLADLEALN--LSGNHLKEVCAGAFEHLPGLRRLDLSHNPLTNLSAFAFAGsnaSVSAPSPL 175
Cdd:cd00116    93 LGPDGCGVLES--LLRSSSLQELKLNNngLGDRGLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAK---ALRANRDL 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727 176 EELILnhivppedqRQNGsfegmVAFEGmVAAALRSGLALRGLTRLELASNHF-----LFLPrDLLAQLPSLRYLDLRNN 250
Cdd:cd00116   168 KELNL---------ANNG-----IGDAG-IRALAEGLKANCNLEVLDLNNNGLtdegaSALA-ETLASLKSLEVLNLGDN 231


                  ..
gi 1039792727 251 SL 252
Cdd:cd00116   232 NL 233
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
47-160 2.61e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 40.15  E-value: 2.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727  47 AFLASGSAQPPPAE---------RCPAACECSEAARTVK----CVNRN----------LLEVPADLPPYVRNLFLTGNQM 103
Cdd:PRK15387  155 SFLPATTAPQTPAEydavwsawrRAAPAEESRGRAAVVQkmraCLNNGnavlnvgesgLTTLPDCLPAHITTLVIPDNNL 234

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039792727 104 TVLPAgafarQPPlaDLEALNLSGNHLKEVCAGAfehlPGLRRLDLSHNPLTNLSAF 160
Cdd:PRK15387  235 TSLPA-----LPP--ELRTLEVSGNQLTSLPVLP----PGLLELSIFSNPLTHLPAL 280
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 90-252 5.92e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 38.62  E-value: 5.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727  90 PPYVRNLFLTGNQMTVLPAGAFARQ-PPLADLEALNLSGNHLKevCAGA---FEHLPG---LRRLDLSHNPLTNLSAFAF 162
Cdd:COG5238   207 NTTVTTLWLKRNPIGDEGAEILAEAlKGNKSLTTLDLSNNQIG--DEGVialAEALKNnttVETLYLSGNQIGAEGAIAL 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039792727 163 AgsnASVSAPSPLEELILNHIvppedqrqNGSFEGMVAF----------------------EGMV--AAALRSGlalRGL 218
Cdd:COG5238   285 A---KALQGNTTLTSLDLSVN--------RIGDEGAIALaeglqgnktlhtlnlayngigaQGAIalAKALQEN---TTL 350

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1039792727 219 TRLELASNHFLFLPRDLLAQL----PSLRYLDLRNNSL 252
Cdd:COG5238   351 HSLDLSDNQIGDEGAIALAKYlegnTTLRELNLGKNNI 388
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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