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Conserved domains on  [gi|1039793076|ref|XP_017168834|]
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sialin isoform X3 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
1-297 2.18e-160

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17381:

Pssm-ID: 452895 [Multi-domain]  Cd Length: 397  Bit Score: 452.70  E-value: 2.18e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076   1 MHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVsdtpethktishy 80
Cdd:cd17381   141 MHAMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV------------- 207
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076  81 ekeyivsslknqlssqkvvpwgsilksLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLC 160
Cdd:cd17381   208 ---------------------------MPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLF 260
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076 161 MILCGQAADYLRVKWNFSTISVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSY 240
Cdd:cd17381   261 MILSGQIADNLREKQNFSTVCVRKIFTLIGMIGPAVFLLAAGFTGCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSY 340
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039793076 241 AGILLGITNTFATIPGMTGPIIAKSLTPDNTIREWQTVFCIAAAINVFGAIFFTLFA 297
Cdd:cd17381   341 AGILLGITNTFATIPGMVGPVIAKSLTHNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
 
Name Accession Description Interval E-value
MFS_SLC17A5 cd17381
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ...
1-297 2.18e-160

Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340939 [Multi-domain]  Cd Length: 397  Bit Score: 452.70  E-value: 2.18e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076   1 MHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVsdtpethktishy 80
Cdd:cd17381   141 MHAMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV------------- 207
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076  81 ekeyivsslknqlssqkvvpwgsilksLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLC 160
Cdd:cd17381   208 ---------------------------MPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLF 260
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076 161 MILCGQAADYLRVKWNFSTISVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSY 240
Cdd:cd17381   261 MILSGQIADNLREKQNFSTVCVRKIFTLIGMIGPAVFLLAAGFTGCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSY 340
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039793076 241 AGILLGITNTFATIPGMTGPIIAKSLTPDNTIREWQTVFCIAAAINVFGAIFFTLFA 297
Cdd:cd17381   341 AGILLGITNTFATIPGMVGPVIAKSLTHNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
2-310 8.47e-86

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 265.07  E-value: 8.47e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076   2 HAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIIC-YYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTISHY 80
Cdd:TIGR00894 153 HKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCeSWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKF 232
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076  81 EKEYIVSSLKNQ-LSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWL 159
Cdd:TIGR00894 233 EKKYINSSLQGQkGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWL 312
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076 160 CMILCGQAADYLRVKWNFSTISVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPS 239
Cdd:TIGR00894 313 CSIFAGYLADFLKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPR 392
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039793076 240 YAGILLGITNTFATIPGMTGPIIAKSLTPDNTIREWQTVFCIAAAINVFGAIFFTLFAKGEVQSWALSDHH 310
Cdd:TIGR00894 393 FLGFIKGITGLPGFIGGLIASTLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKD 463
MFS_1 pfam07690
Major Facilitator Superfamily;
1-260 2.97e-16

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 78.23  E-value: 2.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076   1 MHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILwmWIVSDTPETHKTISHY 80
Cdd:pfam07690 106 ALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVL--LLLPRPPPESKRPKPA 183
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076  81 EKEYIVSslknqlssqkVVPWGSILKSLPLWAIVVAhFSYNWSFYTLLTLLPTYMkEILRFNVQENGFLSALPYFGCWLC 160
Cdd:pfam07690 184 EEARLSL----------IVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGAIG 251
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076 161 MILCGQAADYLRVKwnfstisVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSY 240
Cdd:pfam07690 252 RLLLGRLSDRLGRR-------RRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEE 324
                         250       260
                  ....*....|....*....|
gi 1039793076 241 AGILLGITNTFATIPGMTGP 260
Cdd:pfam07690 325 RGTASGLYNTAGSLGGALGP 344
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
7-300 8.47e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 225180 [Multi-domain]  Cd Length: 448  Bit Score: 49.96  E-value: 8.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076   7 SWAPPLERSKLLTISYAGAQLGTVISLPLS--GIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPET--HKTISHYEK 82
Cdd:COG2271   144 HWFSRKERGTWWSIWNTSHNIGGALAPLVAllAFFAFHGGWRAAFYFPGIIAIIVALILLFLLRDRPQSegLPPIEEYRG 223
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076  83 EYIVSSLKNQLS---SQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWL 159
Cdd:COG2271   224 DPLEIYEEEKENeglTAWQIFVKYVLKNKLIWLLALANVFVYVVRYGINDWGPLYLSEVKGFSLVKANWAISLFEVAGLP 303
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076 160 CMILCGQAADYLrvkwnFStiSVRRIFSLVGMVGPAVFLVAAGF--IGCDYSLAVAFLTISTTLGGFASSgFSINHLDIA 237
Cdd:COG2271   304 GTLLAGWLSDKL-----FK--GRRGPMALIFMLLITASLVLYWLapNGSYLLDAILLFIIGFLIYGPQML-IGLAAAEFV 375
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039793076 238 PSYA-GILLGITNTFATIPGMTGPIIAKSLTPDNTirEWQTVFCIAAAINVFGAIFFTLFAKGE 300
Cdd:COG2271   376 PKKAaGTATGFVGLFAYLIGAALAGLPLGYIADTW--GWDGGFIVLSIAALLAILLLLPVWNAE 437
 
Name Accession Description Interval E-value
MFS_SLC17A5 cd17381
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ...
1-297 2.18e-160

Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340939 [Multi-domain]  Cd Length: 397  Bit Score: 452.70  E-value: 2.18e-160
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076   1 MHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVsdtpethktishy 80
Cdd:cd17381   141 MHAMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV------------- 207
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076  81 ekeyivsslknqlssqkvvpwgsilksLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLC 160
Cdd:cd17381   208 ---------------------------MPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLF 260
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076 161 MILCGQAADYLRVKWNFSTISVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSY 240
Cdd:cd17381   261 MILSGQIADNLREKQNFSTVCVRKIFTLIGMIGPAVFLLAAGFTGCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSY 340
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039793076 241 AGILLGITNTFATIPGMTGPIIAKSLTPDNTIREWQTVFCIAAAINVFGAIFFTLFA 297
Cdd:cd17381   341 AGILLGITNTFATIPGMVGPVIAKSLTHNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
1-297 3.77e-116

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 340.37  E-value: 3.77e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076   1 MHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVsdtpethktishy 80
Cdd:cd17318   132 MHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV------------- 198
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076  81 ekeyivsslknqlssqkvvpwgsilksLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLC 160
Cdd:cd17318   199 ---------------------------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWIC 251
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076 161 MILCGQAADYLRVKWNFSTISVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSY 240
Cdd:cd17318   252 SIVGGYLADWLRSRGILSTTTVRKLFTSIGFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNY 331
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1039793076 241 AGILLGITNTFATIPGMTGPIIAKSLTPDN-TIREWQTVFCIAAAINVFGAIFFTLFA 297
Cdd:cd17318   332 AGTLMGITNTAATIAGIISPLIVGAIVKNDqTIGQWRIVFFISAAIYILGAIFYLIFG 389
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
2-310 8.47e-86

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 265.07  E-value: 8.47e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076   2 HAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIIC-YYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTISHY 80
Cdd:TIGR00894 153 HKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCeSWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKF 232
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076  81 EKEYIVSSLKNQ-LSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWL 159
Cdd:TIGR00894 233 EKKYINSSLQGQkGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWL 312
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076 160 CMILCGQAADYLRVKWNFSTISVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPS 239
Cdd:TIGR00894 313 CSIFAGYLADFLKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPR 392
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039793076 240 YAGILLGITNTFATIPGMTGPIIAKSLTPDNTIREWQTVFCIAAAINVFGAIFFTLFAKGEVQSWALSDHH 310
Cdd:TIGR00894 393 FLGFIKGITGLPGFIGGLIASTLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKD 463
MFS_SLC17A6_7_8_VGluT cd17382
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ...
1-297 9.45e-84

Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340940 [Multi-domain]  Cd Length: 380  Bit Score: 257.27  E-value: 9.45e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076   1 MHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIvsdtpethktishy 80
Cdd:cd17382   125 CHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFWMLV-------------- 190
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076  81 ekeyivsslknqlssqkvvpwgsilkSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLC 160
Cdd:cd17382   191 --------------------------SMPVYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTII 244
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076 161 MILCGQAADYLRVKWNFSTISVRRIFSLVGMVGPAVFLVAAGFIGcDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSY 240
Cdd:cd17382   245 VPIGGQLADYLRSRGILSTTAVRKIFNCGGFGMEATFLLVVAFSH-SPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRY 323
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039793076 241 AGILLGITNTFATIPGMTGPIIAKSLTPDNTIREWQTVFCIAAAINVFGAIFFTLFA 297
Cdd:cd17382   324 ASILMGISNGIGTLSGMVCPVIVGALTKHKTREEWQYVFLIASLVHFFGVIFYAIFA 380
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
1-297 2.99e-66

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 211.64  E-value: 2.99e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076   1 MHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSdtpethktishy 80
Cdd:cd17380   110 MTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYLP------------ 177
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076  81 ekeyivsslknqlssqkvvpwgsilkslPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILrFNVQENGFLSALPYFGCWLC 160
Cdd:cd17380   178 ----------------------------PVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMFPS 228
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076 161 MILCGQAADYLRVKwNFSTISVRRIFSLVGMVGPAVFLVAAGFIgCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSY 240
Cdd:cd17380   229 SNVAGWLADHLISR-GWTVTSVRKLMQSIGFLGPALFLLLLSHT-DSFSLALLCMSVALGLSAFSSSGVLVNHQDIAPNY 306
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039793076 241 AGILLGITNTFATIPGMTGPIIAKSLTpdNTIREWQTVFCIAAAINVFGAIFFTLFA 297
Cdd:cd17380   307 AGIVFGISNTAGTIPGIVGVYLTGYIL--EATGSWSLVFVLAAVVNLVGAVVFLLFG 361
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
6-291 1.30e-24

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 101.88  E-value: 1.30e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076   6 SSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDtpethktishyekeyi 85
Cdd:cd17319   117 AEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ---------------- 180
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076  86 vsslknqlssqkvvpwgsilkslpLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCG 165
Cdd:cd17319   181 ------------------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGG 236
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076 166 QAADYLRVKwnfstisVRRIFSLVGMVGPAVFLVAAGFIGcDYSLAVAFLTISTTLGGFASSGFSINHLDIAP-SYAGIL 244
Cdd:cd17319   237 RLSDRLLRG-------ARRLVIIIGLLLAAVGLLLAYLTT-SPVVAVILLSLAGFGIGAASPVFWSLPADLLPgEAAATA 308
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1039793076 245 LGITNTFATIPGMTGPIIAKSLTpdNTIREWQTVFCIAAAINVFGAI 291
Cdd:cd17319   309 GGLINSGGNLGGFVAPLLIGYLV--DATGSYTAAFLFLAAVALLAAL 353
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
1-293 7.06e-23

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 97.11  E-value: 7.06e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076   1 MHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYY--MNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKtis 78
Cdd:cd06174   105 VLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILLLLVVPDPPESAR--- 181
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076  79 hyekeyivSSLKNQLSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCW 158
Cdd:cd06174   182 --------AKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGA 253
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076 159 LCMILCGQAADYLRvkwnfstisVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAP 238
Cdd:cd06174   254 LGSLLLGLLSDRLI---------GRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPP 324
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1039793076 239 SYAGILLGITNTFATIPGMTGPIIAKSLTPDNTIreWQTVFCIAAAINVFGAIFF 293
Cdd:cd06174   325 EIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFG--LTGAFLVLAVLLLLAAILL 377
MFS_1 pfam07690
Major Facilitator Superfamily;
1-260 2.97e-16

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 78.23  E-value: 2.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076   1 MHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILwmWIVSDTPETHKTISHY 80
Cdd:pfam07690 106 ALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVL--LLLPRPPPESKRPKPA 183
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076  81 EKEYIVSslknqlssqkVVPWGSILKSLPLWAIVVAhFSYNWSFYTLLTLLPTYMkEILRFNVQENGFLSALPYFGCWLC 160
Cdd:pfam07690 184 EEARLSL----------IVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGAIG 251
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076 161 MILCGQAADYLRVKwnfstisVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSY 240
Cdd:pfam07690 252 RLLLGRLSDRLGRR-------RRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEE 324
                         250       260
                  ....*....|....*....|
gi 1039793076 241 AGILLGITNTFATIPGMTGP 260
Cdd:pfam07690 325 RGTASGLYNTAGSLGGALGP 344
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
9-297 1.47e-14

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 73.38  E-value: 1.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076   9 APPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTishyekeyivss 88
Cdd:cd17325   113 APPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNK------------ 180
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076  89 lKNQLSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAA 168
Cdd:cd17325   181 -RAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLS 259
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076 169 DYLRvkwnfstisvRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGIT 248
Cdd:cd17325   260 DRIG----------RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLF 329
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1039793076 249 NTFATIPGMTGPIIAKSLTpdnTIREWQTVFCIAAAINVFGAIFFTLFA 297
Cdd:cd17325   330 NTAFSLGMVLGPLLGGFLY---DAFGFATPFLAAAALLLLAAVLFLLLR 375
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
4-262 4.21e-07

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 50.84  E-value: 4.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076   4 MWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGI-ICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTIS---- 78
Cdd:TIGR00881 107 TVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFgIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPaeem 186
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076  79 -HYEKEYIVSSLKNQLSSQKVVPWgSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGC 157
Cdd:TIGR00881 187 pNEEPDGDAEKKEEELTKKQIFLQ-YVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGG 265
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076 158 WLCMILCGQAADYLrvkwnfstisVRRIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGF----SINH 233
Cdd:TIGR00881 266 LVGTLLAGWLSDKL----------FNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGFLVYGPqmliGVIA 335
                         250       260       270
                  ....*....|....*....|....*....|
gi 1039793076 234 LDIAPSYA-GILLGITNTFATIPGMTGPII 262
Cdd:TIGR00881 336 SELAPKKAaGTAAGFVGFFAYLGGILAGLP 365
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
7-300 8.47e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 225180 [Multi-domain]  Cd Length: 448  Bit Score: 49.96  E-value: 8.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076   7 SWAPPLERSKLLTISYAGAQLGTVISLPLS--GIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPET--HKTISHYEK 82
Cdd:COG2271   144 HWFSRKERGTWWSIWNTSHNIGGALAPLVAllAFFAFHGGWRAAFYFPGIIAIIVALILLFLLRDRPQSegLPPIEEYRG 223
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076  83 EYIVSSLKNQLS---SQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWL 159
Cdd:COG2271   224 DPLEIYEEEKENeglTAWQIFVKYVLKNKLIWLLALANVFVYVVRYGINDWGPLYLSEVKGFSLVKANWAISLFEVAGLP 303
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076 160 CMILCGQAADYLrvkwnFStiSVRRIFSLVGMVGPAVFLVAAGF--IGCDYSLAVAFLTISTTLGGFASSgFSINHLDIA 237
Cdd:COG2271   304 GTLLAGWLSDKL-----FK--GRRGPMALIFMLLITASLVLYWLapNGSYLLDAILLFIIGFLIYGPQML-IGLAAAEFV 375
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039793076 238 PSYA-GILLGITNTFATIPGMTGPIIAKSLTPDNTirEWQTVFCIAAAINVFGAIFFTLFAKGE 300
Cdd:COG2271   376 PKKAaGTATGFVGLFAYLIGAALAGLPLGYIADTW--GWDGGFIVLSIAALLAILLLLPVWNAE 437
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
13-247 1.69e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 49.11  E-value: 1.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076  13 ERSKLLTISYAGAQLGTVISLPLSGIICYyMNWTYVFYLFGiVGIVWFILWMWIVSDTPETHKTISHYEKEyivsslknq 92
Cdd:cd17473   121 ERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYL-LALPVLILVLLFLPEPARKSKSAASPGAA--------- 189
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076  93 lsSQKVVPWGSIlkslplWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSAlpyfgcwlcmilcgqaadylr 172
Cdd:cd17473   190 --TAAALPWKRV------LPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALA--------------------- 240
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039793076 173 vkwnfstisvrrIFSLVGMVGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFAssgfsinhldIAPSYAGILLGI 247
Cdd:cd17473   241 ------------IASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLA----------LASGLWVVLLGA 293
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
13-296 5.89e-06

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 47.18  E-value: 5.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076  13 ERSKLLTISYAGAQLGTVISlPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPEThktishyekeyivsslKNQ 92
Cdd:cd17474   120 ERAKAMGLYEAALGLGIAVG-PLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKEK----------------AKS 182
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076  93 LSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGcwlcmilcGQAADYLR 172
Cdd:cd17474   183 SSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVL--------LALGSLFV 254
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076 173 VKWNFSTISVRRIFsLVGMVGPAVFLVAAGFIGcDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYA-GILLGITNTF 251
Cdd:cd17474   255 GRLLKKRFGARRIL-VIGLLLYALSLLLLGFVP-SLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEErGTASSLYNFV 332
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1039793076 252 ATIPGMTGPIIAKSLTpdnTIREWQTVFCIAAAINVFGAIFFTLF 296
Cdd:cd17474   333 RFLGQAVGPLLFGLLL---EIFGLSAPFLVGAAIALAAAVLLALL 374
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
3-266 1.23e-05

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 46.20  E-value: 1.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076   3 AMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWM--------WIVSDTPETH 74
Cdd:TIGR00895 128 ALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMrflpesidFLVSKRPETV 207
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076  75 KTISHYEKEYIVSSLKNQLSSQKVVP--WGSILK----------SLPLWaivVAHFSYNWSFYTLLTLLPTYMKEiLRFN 142
Cdd:TIGR00895 208 RRIVNAIAPQMQAEAQSALPEQKSTQgtKRSVFKalfqgktariTVLLW---LLYFMLLVGVYFLTNWLPKLMVE-LGFS 283
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076 143 VQENGFLSALPYFGCWLCMILCGQAADYLRVKwnfstisvrriFSLVGMVGPAVFLVAAGFigcDYSLAVAFLTISTTLG 222
Cdd:TIGR00895 284 LSLAATGGALFNFGGVIGSIIFGWLADRLGPR-----------VTALLLLLGAVFAVLVGS---TLFSPTLLLLLGAIAG 349
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1039793076 223 GFASSGFSINHLDIAPSYA--------GILLGITNTFATIpgmtGPIIAKSL 266
Cdd:TIGR00895 350 FFVNGGQSGLYALMALFYPtairatgvGWAIGIGRLGAII----GPILAGYL 397
MFS_1 pfam07690
Major Facilitator Superfamily;
113-296 2.22e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 45.49  E-value: 2.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076 113 IVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAADYLRvkwnfstisvRRIFSLVGMV 192
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFG----------RRRVLLIGLL 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076 193 GPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPIIAKSLTpdnTI 272
Cdd:pfam07690  71 LFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA---SL 147
                         170       180
                  ....*....|....*....|....
gi 1039793076 273 REWQTVFCIAAAINVFGAIFFTLF 296
Cdd:pfam07690 148 FGWRAAFLILAILSLLAAVLLLLP 171
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
9-294 2.95e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 45.23  E-value: 2.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076   9 APPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTishyekeyivss 88
Cdd:cd17324   116 VPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPG------------ 183
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076  89 lknqlSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQAA 168
Cdd:cd17324   184 -----SLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLA 258
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076 169 DylrvkwnfsTISVRRIFSLVGMVgpAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGIT 248
Cdd:cd17324   259 D---------RGGRRALLIALLLL--AAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLY 327
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1039793076 249 NTFATIPGMTGPIIAkSLTPDNTirEWQTVFCIAAAINVFGAIFFT 294
Cdd:cd17324   328 LAAYNLGGALGAALG-GLVLDHG--GWAGVGWVGAALLLLALLLAL 370
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
8-262 1.73e-04

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 42.61  E-value: 1.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076   8 WAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYMNWTYVFYLFGIVGIVWFIL-WMWIvsdtpethktishyeKEYIV 86
Cdd:cd17475   112 WFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLfWLFY---------------REPPA 176
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076  87 SSLKNQLSSQKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCWLCMILCGQ 166
Cdd:cd17475   177 ASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGR 256
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076 167 AADYLRVKwnfstisvRRIFSLVGMVGPAVfLVAAGFIGCDYSLAVAFLTISTTLGGFASSGF-SINHLDIA----PSYA 241
Cdd:cd17475   257 VSDRVFGG--------RRRPVLVITAAIAA-AALLVLSLLSPGTPLWLLVLLLILLGLFAIGWnGLYLTLVAesagPEQA 327
                         250       260
                  ....*....|....*....|.
gi 1039793076 242 GILLGITNTFATIPGMTGPII 262
Cdd:cd17475   328 GTALGLANTINFIGIAIGPPL 348
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
1-265 2.11e-04

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 42.62  E-value: 2.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076   1 MHAMWSSWAPPLERSKLLTISYAGAQLGTVislpLSGII---CYYM-------NWTYVFYLFGIVGIVWFILWMWIVSDT 70
Cdd:cd17327   115 FILYLGMWYKREEQAKRIAFFYAAAGLGSI----FGGLLaygVFKIlgvgglaGWRWLFIIEGLITIIIGLVIFFWLPDN 190
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076  71 PETHKTISHYEKEYIVSSLKNQ---LSSQKVVP--WGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQE 145
Cdd:cd17327   191 PSKAWFLTEEEKELAVERLRANqtgKGDQKFKWkqIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKSLGFYSLQT 270
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076 146 NGFLSALPYFGCwLCMILCGQAADYLRVKWNFSTisvrrIFSLVGMVGPAVflvaagFIGCDYSLAVAFLTISTTLGGFA 225
Cdd:cd17327   271 NLLSVPIGALGA-VSLLIAALLSDRFKKRGLFAI-----FACVLALVGSII------LLAAPNPPGAYFAAYILGGGSYA 338
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1039793076 226 SSGFSINHL-DIAPSYAG--ILLGITNTFATIPGMTGPIIAKS 265
Cdd:cd17327   339 GFPILLSWIsSNCAGYTKraTVLAIMLIFYNVGNIVAPQIFRA 381
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
8-296 3.72e-03

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 38.76  E-value: 3.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076   8 WAPPLERSKLLTISYAGAQLGTVISLPLSGIICYYM---NWTYVFYLFGIVGIVWFILWMWIVSDTPET------HKTIS 78
Cdd:cd17345   123 WFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFgdgWWRGAFIFPAIIAIIVAVIVLFLGKDTPESeglppiEEYKG 202
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076  79 HYEKEYIVSSLKNQLSSQKVVpWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALPYFGCW 158
Cdd:cd17345   203 DYPEEADGEEEEQELSAWEIF-VKYVLKNKLLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAI 281
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039793076 159 LCMILCGQAADYLrvkwnfstISVRRifSLVGMVgpAVFLVAAGFIGCDYSLAVAFLTISTTLGGFASSG----FSINHL 234
Cdd:cd17345   282 PGTLLAGWLSDKL--------FKGRR--APTGII--FMILVIVALIVYWLAPNVLVDLIALIALGFLIYGpvmlIGLQAL 349
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039793076 235 DIAPSYA-GILLGITNTFATIPGMTGPIIAKSLTPDNTirEWQTVFcIAAAINVFGAIFFTLF 296
Cdd:cd17345   350 ELVPKKAaGTAAGLTGLFGYLGGSVLATALIGIIVDHF--GWNGGF-IVLLASCILAIIFLAL 409
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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