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Conserved domains on  [gi|1039741886|ref|XP_017170682|]
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tetratricopeptide repeat protein 6 isoform X10 [Mus musculus]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
887-957 5.79e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.85  E-value: 5.79e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039741886 887 NLAFVYCRRGAIYRKLGKLQSAMNDLQEAIFQEPFFLNAYWHRHFIYLFQDKVNDALDDLNFITKYNKNHA 957
Cdd:COG0457    74 DDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDA 144
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
887-957 5.79e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.85  E-value: 5.79e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039741886 887 NLAFVYCRRGAIYRKLGKLQSAMNDLQEAIFQEPFFLNAYWHRHFIYLFQDKVNDALDDLNFITKYNKNHA 957
Cdd:COG0457    74 DDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDA 144
TPR_1 pfam00515
Tetratricopeptide repeat;
889-916 9.79e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 37.40  E-value: 9.79e-04
                          10        20
                  ....*....|....*....|....*...
gi 1039741886 889 AFVYCRRGAIYRKLGKLQSAMNDLQEAI 916
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKAL 28
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 889-922 1.70e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.66  E-value: 1.70e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1039741886  889 AFVYCRRGAIYRKLGKLQSAMNDLQEAIFQEPFF 922
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
887-957 5.79e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.85  E-value: 5.79e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039741886 887 NLAFVYCRRGAIYRKLGKLQSAMNDLQEAIFQEPFFLNAYWHRHFIYLFQDKVNDALDDLNFITKYNKNHA 957
Cdd:COG0457    74 DDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDA 144
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
885-957 4.44e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 46.15  E-value: 4.44e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039741886 885 KRNLAFVYCRRGAIYRKLGKLQSAMNDLQEAIFQEPFFLNAYWHRHFIYLFQDKVNDALDDLNFITKYNKNHA 957
Cdd:COG0457    38 DPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDA 110
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
887-947 4.60e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 45.68  E-value: 4.60e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039741886 887 NLAFVYCRRGAIYRKLGKLQSAMNDLQEAIFQEPFFLNAYWHRHFIYLFQDKVNDALDDLN 947
Cdd:COG4785    71 DLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFD 131
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
887-947 4.90e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 46.15  E-value: 4.90e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039741886 887 NLAFVYCRRGAIYRKLGKLQSAMNDLQEAIFQEPFFLNAYWHRHFIYLFQDKVNDALDDLN 947
Cdd:COG0457     6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYE 66
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 873-957 1.04e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 43.26  E-value: 1.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039741886 873 EVEKLTQEIKSEKRNLAFVYCRRGAIYRKLGKLQSAMNDLQEAIFQEPFFLNAYWHRHFIYLFQDKVNDALDDLNFITKY 952
Cdd:COG4783    22 EAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKL 101


                  ....*
gi 1039741886 953 NKNHA 957
Cdd:COG4783   102 DPEHP 106
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
887-947 1.56e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 44.61  E-value: 1.56e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039741886 887 NLAFVYCRRGAIYRKLGKLQSAMNDLQEAIFQEPFFLNAYWHRHFIYLFQDKVNDALDDLN 947
Cdd:COG0457   108 DDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLE 168
TPR_1 pfam00515
Tetratricopeptide repeat;
889-916 9.79e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 37.40  E-value: 9.79e-04
                          10        20
                  ....*....|....*....|....*...
gi 1039741886 889 AFVYCRRGAIYRKLGKLQSAMNDLQEAI 916
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKAL 28
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 889-922 1.70e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.66  E-value: 1.70e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1039741886  889 AFVYCRRGAIYRKLGKLQSAMNDLQEAIFQEPFF 922
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
887-947 4.72e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 39.51  E-value: 4.72e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039741886 887 NLAFVYCRRGAIYRKLGKLQSAMNDLQEAIFQEPFFLNAYWHRHFIYLFQDKVNDALDDLN 947
Cdd:COG4785   105 DLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLE 165
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
887-947 7.17e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 36.69  E-value: 7.17e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039741886 887 NLAFVYCRRGAIYRKLGKLQSAMnDLQEAIFQEPFFLNAYWHRHFIYLFQDKVNDALDDLN 947
Cdd:COG3063    24 DNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYDEALAYLE 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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