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Conserved domains on  [gi|1039743058|ref|XP_017170860|]
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adhesion G-protein coupled receptor V1 isoform X8 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 1369-1518 2.77e-17

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


:

Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 81.66  E-value: 2.77e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1369 PFRNNTIANFTFSAWVMPNANTNGF-LIAKDDSHGSIYYGVKiQTNETHVTLslhYKTFGSNVTYIAKSTVmkylEEGVW 1447
Cdd:pfam13385   10 PDALLPTSDFTVSAWVKPDSLPGWArAIISSSGGGGYSLGLD-GDGRLRFAV---NGGNGGWDTVTSGASV----PLGQW 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039743058 1448 LHVLIILDDGIIEFYLDGKAMPRGikSLKGEAITDGPGILRIGAGMDGGARFTGWMQDVRTYERKLTPEEI 1518
Cdd:pfam13385   82 THVAVTYDGGTLRLYVNGVLVGSS--TLTGGPPPGTGGPLYIGRSPGGDDYFNGLIDEVRIYDRALSAAEI 150
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 4291-4379 7.49e-17

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


:

Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 78.45  E-value: 7.49e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  4291 GRFSFSHEQLHVSEAAQRVNVTVVRSGGSFGRARVLYETGSRTAEAGWDFVPASGELLFEAREKMKSLYIDILDDNLPEG 4370
Cdd:smart00237    2 GSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYEK 81


                    ....*....
gi 1039743058  4371 PEEFVLAIT 4379
Cdd:smart00237   82 DETFYVRLS 90
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 4275-4511 1.66e-14

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 80.99  E-value: 1.66e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 4275 ASVSARITMVASDAPYGRFSFSHEQLHVSEAAQRVNVTVVRSGGSFGR-ARVLYETGSRTAEAGWDFVPASGELLFEARE 4353
Cdd:TIGR00845  384 VSMHEVATDDEENDPVSKIFFEPGHYTCLENCGTVALTVVRRGGDLTNtVYVDYRTEDGTANAGSDYEFTEGTLVFKPGE 463

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 4354 KMKSLYIDILDDNLPEGPEEFVLAITRVDLQgrgydftiQENGLQIDQPPE----IGNISIVRIIIMKNDNAeGIIEFDP 4429
Cdd:TIGR00845  464 TQKEFRIGIIDDDIFEEDEHFYVRLSNLRVG--------SEDGILEANHVSavaqLASPNTATVTILDDDHA-GIFTFEE 534

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 4430 KYTDISveEDAGVITLPVLRLHGTYGHVSADFSSRGFSAVPGG--YVLHGSSVTFQHGQNLSFINVSIIDDNGSEFEKQF 4507
Cdd:TIGR00845  535 DVFHVS--ESIGIMEVKVLRTSGARGTVIVPYRTVEGTARGGGkdFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTF 612


                   ....
gi 1039743058 4508 EILL 4511
Cdd:TIGR00845  613 FIEL 616
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2628-2812 2.15e-14

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 80.61  E-value: 2.15e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2628 SVELVIYRTGGSLGQ-VMVEWRVVGGTATEGLDFMGAGDILTFAEGETKKMAILTILDDSEPEDNESILVRL----VATE 2702
Cdd:TIGR00845  417 TVALTVVRRGGDLTNtVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLsnlrVGSE 496

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2703 GGSRI---------LPSSDTVTVNILANDNvAGIVSFQTASRSVIGHEGEMlQFHVVRTPPGRGNVTVNWKVV---GQNL 2770
Cdd:TIGR00845  497 DGILEanhvsavaqLASPNTATVTILDDDH-AGIFTFEEDVFHVSESIGIM-EVKVLRTSGARGTVIVPYRTVegtARGG 574

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1039743058 2771 EVNFANFTGQLFFSEGTLNKTIFVHLLDDNIPEEKEVYQVVL 2812
Cdd:TIGR00845  575 GKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1752-1974 2.71e-14

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 80.22  E-value: 2.71e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1752 HITVQEEDGEIRLLVIRAQGLLGR-VTVGFRTVSLTAFSPEDYQSTAGTLEFQSGERYKYIFVNITDNSIPELEKSFKVE 1830
Cdd:TIGR00845  408 HYTCLENCGTVALTVVRRGGDLTNtVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVR 487

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1831 LLNLDGGVSDLFRVDGSGSGEadtdfflppvlphASLGVASQILVTIAASDHAhGVFEFSPESLFVSgtepeDGYSTVVL 1910
Cdd:TIGR00845  488 LSNLRVGSEDGILEANHVSAV-------------AQLASPNTATVTILDDDHA-GIFTFEEDVFHVS-----ESIGIMEV 548

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039743058 1911 NVTRTRGALSAVTLQ-WKVDSDLDG---DLAITSGNITFETGQRIASITVEILSDEEPELDKALTVSI 1974
Cdd:TIGR00845  549 KVLRTSGARGTVIVPyRTVEGTARGggkDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1907-2101 4.94e-14

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 79.45  E-value: 4.94e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1907 TVVLNVTRTRGALS-AVTLQWKVDsdlDG------DLAITSGNITFETGQRIASITVEILSDEEPELDKALTVSILNVSS 1979
Cdd:TIGR00845  417 TVALTVVRRGGDLTnTVYVDYRTE---DGtanagsDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRV 493

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1980 GS---------------LGVLTNATLTILaSDDPYGVFIFPNKTrpLSVEEATQNVTLSIIRLKGLMGEVAVSYATIDDM 2044
Cdd:TIGR00845  494 GSedgileanhvsavaqLASPNTATVTIL-DDDHAGIFTFEEDV--FHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGT 570

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1039743058 2045 ekppyfppnlarATQGG-DYISASGLALFRANQTEATITISILDDAEPERSESVFIEL 2101
Cdd:TIGR00845  571 ------------ARGGGkDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2518-2698 1.67e-13

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 77.52  E-value: 1.67e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2518 GQAVAGSDYEPvTRQWAVILEGDEFANLTVSVLPDDAPEMDESFLISLLEVHL-----MNISDSFKNQPTIGHPNTSAVV 2592
Cdd:TIGR00845  442 GTANAGSDYEF-TEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVgsedgILEANHVSAVAQLASPNTATVT 520

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2593 IgLNGDAFGVFiiysvspnTSEDGLcVEVQEQPQTsVELVIYRTGGSLGQVMVEWRVVGGTATEGL-DFMGAGDILTFAE 2671
Cdd:TIGR00845  521 I-LDDDHAGIF--------TFEEDV-FHVSESIGI-MEVKVLRTSGARGTVIVPYRTVEGTARGGGkDFEDTCGELEFEN 589

                          170       180
                   ....*....|....*....|....*..
gi 1039743058 2672 GETKKMAILTILDDSEPEDNESILVRL 2698
Cdd:TIGR00845  590 DETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2898-3098 1.34e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 74.83  E-value: 1.34e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2898 TEGNLAEPESDFIPVVGSLVLEEGETTAAISITVLEDDIPELKEYFLVNLTHV------DLIMAPLTSSPPRLDSEgLTA 2971
Cdd:TIGR00845  439 TEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLrvgsedGILEANHVSAVAQLASP-NTA 517

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2972 QIVIDANDGAqGMIEWQRNRFEVNETDGVVTLVAQRSRAALGQVSLFMYAQNLEAQAGL-DYMCTPQILHFTDGERFKHV 3050
Cdd:TIGR00845  518 TVTILDDDHA-GIFTFEEDVFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTARGGGkDFEDTCGELEFENDETEKTI 596

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1039743058 3051 DVMILDDDMPEGDERFQLLLTNPSPGLELGKNTIALITVLANDDGPGV 3098
Cdd:TIGR00845  597 RVKIVDDEEYEKNDTFFIELGEPRWAKRGIKAALLLNETITDDDQKLT 644
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2151-2346 1.75e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 74.44  E-value: 1.75e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2151 HVAENHVGPIINVTRTGGTFAD-VSVKFKAVPITAAAGEDYSIASSDVVLLEGETTKAVPIYIINDIYPELEETFLVQLL 2229
Cdd:TIGR00845  410 TCLENCGTVALTVVRRGGDLTNtVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLS 489

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2230 N---ETTGGATLGPLREAVITIEA---------SDDPYGLFGFQNTKFIVEEpefNSVRVNVPIIRNSGTLGNVTVQWvA 2297
Cdd:TIGR00845  490 NlrvGSEDGILEANHVSAVAQLASpntatvtilDDDHAGIFTFEEDVFHVSE---SIGIMEVKVLRTSGARGTVIVPY-R 565

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039743058 2298 IINGQfATG---DLRVVSGNVTFAPGETIQTLLLEVLADDVPEIEEVVQVQL 2346
Cdd:TIGR00845  566 TVEGT-ARGggkDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1649-1831 2.58e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 73.67  E-value: 2.58e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1649 DFANASGTITFLPWQRSEVLNLYVLDEDMPELNEYFRVTL--VSAVPGDGKLGSTPISGASIDPEKETTGITVKASDHPy 1726
Cdd:TIGR00845  449 DYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLsnLRVGSEDGILEANHVSAVAQLASPNTATVTILDDDHA- 527

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1727 GLMQFstglppqpEDSmslpassvpHITVQEEDGEIRLLVIRAQGLLGRVTVGFRTVSLTA-FSPEDYQSTAGTLEFQSG 1805
Cdd:TIGR00845  528 GIFTF--------EED---------VFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTArGGGKDFEDTCGELEFEND 590

                          170       180
                   ....*....|....*....|....*.
gi 1039743058 1806 ERYKYIFVNITDNSIPELEKSFKVEL 1831
Cdd:TIGR00845  591 ETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1028-1231 2.57e-11

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 70.59  E-value: 2.57e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1028 NDDP--VYFaEPCVLRVQE--GETANFTVLRNGSVDGACTVQYATVDGKASGEEgDFAPVEKgeTLVFEVGSREQSISVH 1103
Cdd:TIGR00845  396 NDPVskIFF-EPGHYTCLEncGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGS-DYEFTEG--TLVFKPGETQKEFRIG 471

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1104 VKDDGIPETDEPFYIVLFN---STGDTVVYEYG-----------VATVIIeANDDPNGVFSLE-PIDKAVEEGKTNAFWI 1168
Cdd:TIGR00845  472 IIDDDIFEEDEHFYVRLSNlrvGSEDGILEANHvsavaqlaspnTATVTI-LDDDHAGIFTFEeDVFHVSESIGIMEVKV 550

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039743058 1169 LRHRGHFGNVSVAWQLFQNASLQPGQEFYETSGTVNFTDGEETKPVILRAFPDRIPEFNE-FYI 1231
Cdd:TIGR00845  551 LRTSGARGTVIVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDtFFI 614
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 3026-3197 3.94e-10

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 66.74  E-value: 3.94e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 3026 AQAGLDYMCTPQILHFTDGERFKHVDVMILDDDMPEGDERFQLLLTNPSPGLE--------------LGKNTIALITVLa 3091
Cdd:TIGR00845  444 ANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSEdgileanhvsavaqLASPNTATVTIL- 522

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 3092 NDDGPGVLSFNNSghiflreptSLYVQESVAVLVIVREPAQGLFGTVAVQFVVTEVNSSTESKDLSPSKGFIVLEEGVRS 3171
Cdd:TIGR00845  523 DDDHAGIFTFEED---------VFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTARGGGKDFEDTCGELEFENDETE 593

                          170       180
                   ....*....|....*....|....*.
gi 1039743058 3172 KTLRISAILDTEPEMDEHFVCTLFNP 3197
Cdd:TIGR00845  594 KTIRVKIVDDEEYEKNDTFFIELGEP 619
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 3610-3766 7.65e-09

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 62.50  E-value: 7.65e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 3610 SDFIPSLGELIFEPGDKEAIIAVNVLDDTVPEKEESFRVQLKSPRGGAEIGINSSVR--------------VTVLANDGA 3675
Cdd:TIGR00845  448 SDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSEDGILEANHvsavaqlaspntatVTILDDDHA 527

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 3676 yGVVAFAqnslHKQLEELERDSLVTLNVERLRGTHGRI-----TVAWEAAGSVSDVFPTSGVISFTEDQAMSMITLTVLA 3750
Cdd:TIGR00845  528 -GIFTFE----EDVFHVSESIGIMEVKVLRTSGARGTVivpyrTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVD 602

                          170
                   ....*....|....*.
gi 1039743058 3751 DDLPELSEAVVVTLTQ 3766
Cdd:TIGR00845  603 DEEYEKNDTFFIELGE 618
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 79-262 2.04e-07

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 57.49  E-value: 2.04e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058   79 LVIERIGEPANVTAIVSLSGEDT-----GDFFDTYAAAFIPARGTNRTVYIAVCDDDLPEPDETFTFHLT---------- 143
Cdd:TIGR00845  420 LTVVRRGGDLTNTVYVDYRTEDGtanagSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSnlrvgsedgi 499

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  144 LQKPSANVK--LGWPRAASVTILSNDNAfGIISFsTPSSISVIEPRSRnasVPLTLIREKGTYGMVTVTF-DVSGGPNPP 220
Cdd:TIGR00845  500 LEANHVSAVaqLASPNTATVTILDDDHA-GIFTF-EEDVFHVSESIGI---MEVKVLRTSGARGTVIVPYrTVEGTARGG 574

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1039743058  221 EEDLNPVRGNITFPPGRATVIYNVTVLDDEVPENDELFLIQL 262
Cdd:TIGR00845  575 GKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 3818-4030 2.19e-07

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 57.49  E-value: 2.19e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 3818 ENITVVQLHIVRDKGlfgDISIHLIAkpnfllhinNQATED------EDFVLQDSVIIMKENIKETHAEVAILPDEVPEL 3891
Cdd:TIGR00845  413 ENCGTVALTVVRRGG---DLTNTVYV---------DYRTEDgtanagSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEE 480

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 3892 DEGLIVTIAAVNLVNPNFPAEQPRVQR------PRMESAEILieeNDDPRGIFNF-----HVVRDVGgviiahegpppln 3960
Cdd:TIGR00845  481 DEHFYVRLSNLRVGSEDGILEANHVSAvaqlasPNTATVTIL---DDDHAGIFTFeedvfHVSESIG------------- 544

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039743058 3961 VLQVPVVRMAGTFETVNVYWKATPDSA--GLEDFQPSHGMLQFADGQVIAPILVTIIDDSEFELLETFTISL 4030
Cdd:TIGR00845  545 IMEVKVLRTSGARGTVIVPYRTVEGTArgGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 273-515 7.06e-07

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 55.95  E-value: 7.06e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  273 ASRSSVEIIVKKNDSP--VNFMQSVYVVPEDDHVLTIPVLRgkdsDGnliGSDETQVSIRYKvmTWDSTAHAQQNVDFID 350
Cdd:TIGR00845  384 VSMHEVATDDEENDPVskIFFEPGHYTCLENCGTVALTVVR----RG---GDLTNTVYVDYR--TEDGTANAGSDYEFTE 454

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  351 lqpdTTLVFPPFVHESHLKFQIIDDLIPEIAESFHI------------MLLKNTLQGDAVLMGPSTVQVTIKPNDKPyGV 418
Cdd:TIGR00845  455 ----GTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVrlsnlrvgsedgILEANHVSAVAQLASPNTATVTILDDDHA-GI 529

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  419 LSFNSILFERpviidedTASSSRFeEIAVVRNGGTHGNVSVSWVLTRNSSDPSPVtaDITPASGTLQFAQGQMLAPISLV 498
Cdd:TIGR00845  530 FTFEEDVFHV-------SESIGIM-EVKVLRTSGARGTVIVPYRTVEGTARGGGK--DFEDTCGELEFENDETEKTIRVK 599

                          250
                   ....*....|....*..
gi 1039743058  499 VFDDDLPEEAEAYLLTI 515
Cdd:TIGR00845  600 IVDDEEYEKNDTFFIEL 616
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 3419-3460 6.86e-05

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 42.84  E-value: 6.86e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1039743058 3419 FAWHQTLPVRGVLGMALFSRGGSVFLAISQANIRqtSLLFTW 3460
Cdd:pfam03736    2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGD--SVIYRW 41
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 4418-4657 4.50e-04

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 46.71  E-value: 4.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 4418 NDNAEGIIeFDP-KYTdisVEEDAGVITLPVLRLHGTYG-HVSADFSSRGFSAVPGG-YVLHGSSVTFQHGQNLSFINVS 4494
Cdd:TIGR00845  396 NDPVSKIF-FEPgHYT---CLENCGTVALTVVRRGGDLTnTVYVDYRTEDGTANAGSdYEFTEGTLVFKPGETQKEFRIG 471

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 4495 IIDDNGSEFEKQFEILL--------------IGATGGAILGRHLVSKITIAKSDSPfGIIRFlNQSKISLPNPSSTMALH 4560
Cdd:TIGR00845  472 IIDDDIFEEDEHFYVRLsnlrvgsedgileaNHVSAVAQLASPNTATVTILDDDHA-GIFTF-EEDVFHVSESIGIMEVK 549

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 4561 LVleRTGGLLGEIQVSWEVVGPDAEEplppHNGDFADpVSGTVSFGDGEgGVRSIILRVCPHEETEAEETFIVQLKPLRE 4640
Cdd:TIGR00845  550 VL--RTSGARGTVIVPYRTVEGTARG----GGKDFED-TCGELEFENDE-TEKTIRVKIVDDEEYEKNDTFFIELGEPRW 621

                          250       260
                   ....*....|....*....|
gi 1039743058 4641 AKLD---PRAKAVTLTGASK 4657
Cdd:TIGR00845  622 AKRGikaALLLNETITDDDQ 641
caca super family cl36745
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 707-1001 4.61e-04

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00845:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 46.71  E-value: 4.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  707 RDGTDGQATVYWSLRPSGFNSKAVTldDAGPFNGSVVFLSGQNETSINITVKGDDIPELNET--VTLSLDRVSVDSDVLK 784
Cdd:TIGR00845  424 RRGGDLTNTVYVDYRTEDGTANAGS--DYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHfyVRLSNLRVGSEDGILE 501

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  785 SGYTSR----------DLIILEnDDPGGIFEFSYDSRgpYVIKEGDAVELRITRSRGSLVKQFLRFHVE---PRESNE-F 850
Cdd:TIGR00845  502 ANHVSAvaqlaspntaTVTILD-DDHAGIFTFEEDVF--HVSESIGIMEVKVLRTSGARGTVIVPYRTVegtARGGGKdF 578

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  851 YGNMGVLEFTPGEREVVITLLTRLDGTPELDEHFWVILSSHGERESKLGCATLVNITILKNDYPHGIIEFVSDGLSASIK 930
Cdd:TIGR00845  579 EDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKAALLLNETITDDDQKLTSKEEEERRIAEMGK 658

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039743058  931 ESKGEDIyhAVYGVIRTRGNFGAVnVSWMVSpdfTQDVFPVQGTVCFGDQeFFKNITVYSLVDEIPEEMEE 1001
Cdd:TIGR00845  659 PRLGEHT--KLEVIIEESYEFKST-VDKLIK---KTNLALVVGTHSWREQ-FIEAITVSAGDDDDDDEDGE 722
Calx-beta super family cl02522
Calx-beta domain;
1596-1688 1.60e-03

Calx-beta domain;


The actual alignment was detected with superfamily member pfam03160:

Pssm-ID: 413355 [Multi-domain]  Cd Length: 91  Bit Score: 40.70  E-value: 1.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1596 GLFGFTGACIPEMTEEGSTVSCVVeRTRGAL-GYVHV-FYTISQIESEGinylvDDFANASGTITFLPWQRSEVLNLYVL 1673
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVV-RMSGTLrRTVVVpYRTEDGTATAG-----DDYEPVEGELVFGPGETEKCINVTII 75

                           90
                   ....*....|....*
gi 1039743058 1674 DEDMPELNEYFRVTL 1688
Cdd:pfam03160   76 DDDVYEGDENFFVLL 90
Calx-beta super family cl02522
Calx-beta domain;
4057-4148 3.82e-03

Calx-beta domain;


The actual alignment was detected with superfamily member smart00237:

Pssm-ID: 413355 [Multi-domain]  Cd Length: 90  Bit Score: 39.55  E-value: 3.82e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  4057 GIFGFEKKTVMV---DGPllsddpdsyVTLTVVRSPGGKGAVRLHWAIEE---KAKDDLSPLNGTLYFDETESQKSVILH 4130
Cdd:smart00237    2 GSVGFEQPVYTVsesDGE---------VEVCVVRTGGARGPVVVPYSTEDgtaTAGSDYEPVPGELTFPPGETEKEIRIK 72

                            90
                    ....*....|....*...
gi 1039743058  4131 TLKDGMVGEDRRFIIELT 4148
Cdd:smart00237   73 IIDDDIYEKDETFYVRLS 90
 
Name Accession Description Interval E-value
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 1369-1518 2.77e-17

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 81.66  E-value: 2.77e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1369 PFRNNTIANFTFSAWVMPNANTNGF-LIAKDDSHGSIYYGVKiQTNETHVTLslhYKTFGSNVTYIAKSTVmkylEEGVW 1447
Cdd:pfam13385   10 PDALLPTSDFTVSAWVKPDSLPGWArAIISSSGGGGYSLGLD-GDGRLRFAV---NGGNGGWDTVTSGASV----PLGQW 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039743058 1448 LHVLIILDDGIIEFYLDGKAMPRGikSLKGEAITDGPGILRIGAGMDGGARFTGWMQDVRTYERKLTPEEI 1518
Cdd:pfam13385   82 THVAVTYDGGTLRLYVNGVLVGSS--TLTGGPPPGTGGPLYIGRSPGGDDYFNGLIDEVRIYDRALSAAEI 150
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 4291-4379 7.49e-17

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 78.45  E-value: 7.49e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  4291 GRFSFSHEQLHVSEAAQRVNVTVVRSGGSFGRARVLYETGSRTAEAGWDFVPASGELLFEAREKMKSLYIDILDDNLPEG 4370
Cdd:smart00237    2 GSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYEK 81


                    ....*....
gi 1039743058  4371 PEEFVLAIT 4379
Cdd:smart00237   82 DETFYVRLS 90
Calx-beta pfam03160
Calx-beta domain;
4291-4379 4.82e-16

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 76.13  E-value: 4.82e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 4291 GRFSFSHEQLHVSEAAQRVNVTVVRSGGSFGRA-RVLYETGSRTAEAGWDFVPASGELLFEAREKMKSLYIDILDDNLPE 4369
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTLRRTvVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVYE 81

                           90
                   ....*....|
gi 1039743058 4370 GPEEFVLAIT 4379
Cdd:pfam03160   82 GDENFFVLLS 91
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 4275-4511 1.66e-14

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 80.99  E-value: 1.66e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 4275 ASVSARITMVASDAPYGRFSFSHEQLHVSEAAQRVNVTVVRSGGSFGR-ARVLYETGSRTAEAGWDFVPASGELLFEARE 4353
Cdd:TIGR00845  384 VSMHEVATDDEENDPVSKIFFEPGHYTCLENCGTVALTVVRRGGDLTNtVYVDYRTEDGTANAGSDYEFTEGTLVFKPGE 463

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 4354 KMKSLYIDILDDNLPEGPEEFVLAITRVDLQgrgydftiQENGLQIDQPPE----IGNISIVRIIIMKNDNAeGIIEFDP 4429
Cdd:TIGR00845  464 TQKEFRIGIIDDDIFEEDEHFYVRLSNLRVG--------SEDGILEANHVSavaqLASPNTATVTILDDDHA-GIFTFEE 534

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 4430 KYTDISveEDAGVITLPVLRLHGTYGHVSADFSSRGFSAVPGG--YVLHGSSVTFQHGQNLSFINVSIIDDNGSEFEKQF 4507
Cdd:TIGR00845  535 DVFHVS--ESIGIMEVKVLRTSGARGTVIVPYRTVEGTARGGGkdFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTF 612


                   ....
gi 1039743058 4508 EILL 4511
Cdd:TIGR00845  613 FIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2628-2812 2.15e-14

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 80.61  E-value: 2.15e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2628 SVELVIYRTGGSLGQ-VMVEWRVVGGTATEGLDFMGAGDILTFAEGETKKMAILTILDDSEPEDNESILVRL----VATE 2702
Cdd:TIGR00845  417 TVALTVVRRGGDLTNtVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLsnlrVGSE 496

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2703 GGSRI---------LPSSDTVTVNILANDNvAGIVSFQTASRSVIGHEGEMlQFHVVRTPPGRGNVTVNWKVV---GQNL 2770
Cdd:TIGR00845  497 DGILEanhvsavaqLASPNTATVTILDDDH-AGIFTFEEDVFHVSESIGIM-EVKVLRTSGARGTVIVPYRTVegtARGG 574

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1039743058 2771 EVNFANFTGQLFFSEGTLNKTIFVHLLDDNIPEEKEVYQVVL 2812
Cdd:TIGR00845  575 GKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1752-1974 2.71e-14

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 80.22  E-value: 2.71e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1752 HITVQEEDGEIRLLVIRAQGLLGR-VTVGFRTVSLTAFSPEDYQSTAGTLEFQSGERYKYIFVNITDNSIPELEKSFKVE 1830
Cdd:TIGR00845  408 HYTCLENCGTVALTVVRRGGDLTNtVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVR 487

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1831 LLNLDGGVSDLFRVDGSGSGEadtdfflppvlphASLGVASQILVTIAASDHAhGVFEFSPESLFVSgtepeDGYSTVVL 1910
Cdd:TIGR00845  488 LSNLRVGSEDGILEANHVSAV-------------AQLASPNTATVTILDDDHA-GIFTFEEDVFHVS-----ESIGIMEV 548

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039743058 1911 NVTRTRGALSAVTLQ-WKVDSDLDG---DLAITSGNITFETGQRIASITVEILSDEEPELDKALTVSI 1974
Cdd:TIGR00845  549 KVLRTSGARGTVIVPyRTVEGTARGggkDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1907-2101 4.94e-14

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 79.45  E-value: 4.94e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1907 TVVLNVTRTRGALS-AVTLQWKVDsdlDG------DLAITSGNITFETGQRIASITVEILSDEEPELDKALTVSILNVSS 1979
Cdd:TIGR00845  417 TVALTVVRRGGDLTnTVYVDYRTE---DGtanagsDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRV 493

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1980 GS---------------LGVLTNATLTILaSDDPYGVFIFPNKTrpLSVEEATQNVTLSIIRLKGLMGEVAVSYATIDDM 2044
Cdd:TIGR00845  494 GSedgileanhvsavaqLASPNTATVTIL-DDDHAGIFTFEEDV--FHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGT 570

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1039743058 2045 ekppyfppnlarATQGG-DYISASGLALFRANQTEATITISILDDAEPERSESVFIEL 2101
Cdd:TIGR00845  571 ------------ARGGGkDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
Calx-beta pfam03160
Calx-beta domain;
1751-1831 1.01e-13

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 69.59  E-value: 1.01e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1751 PHITVQEEDGEIRLLVIRAQGLLGR-VTVGFRTVSLTAFSPEDYQSTAGTLEFQSGERYKYIFVNITDNSIPELEKSFKV 1829
Cdd:pfam03160    9 PTYQVSENDGVAEVCVVRMSGTLRRtVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVYEGDENFFV 88


                   ..
gi 1039743058 1830 EL 1831
Cdd:pfam03160   89 LL 90
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2518-2698 1.67e-13

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 77.52  E-value: 1.67e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2518 GQAVAGSDYEPvTRQWAVILEGDEFANLTVSVLPDDAPEMDESFLISLLEVHL-----MNISDSFKNQPTIGHPNTSAVV 2592
Cdd:TIGR00845  442 GTANAGSDYEF-TEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVgsedgILEANHVSAVAQLASPNTATVT 520

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2593 IgLNGDAFGVFiiysvspnTSEDGLcVEVQEQPQTsVELVIYRTGGSLGQVMVEWRVVGGTATEGL-DFMGAGDILTFAE 2671
Cdd:TIGR00845  521 I-LDDDHAGIF--------TFEEDV-FHVSESIGI-MEVKVLRTSGARGTVIVPYRTVEGTARGGGkDFEDTCGELEFEN 589

                          170       180
                   ....*....|....*....|....*..
gi 1039743058 2672 GETKKMAILTILDDSEPEDNESILVRL 2698
Cdd:TIGR00845  590 DETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 4224-4378 1.03e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 75.21  E-value: 1.03e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 4224 EFVETSGQLTMLDGQTAATVVIQALNDDIPEEKCHYEFQLTEISEGR---MLHEASVSAR---------ITMVASDAPYG 4291
Cdd:TIGR00845  449 DYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSedgILEANHVSAVaqlaspntaTVTILDDDHAG 528

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 4292 RFSFSHEQLHVSEAAQRVNVTVVRSGGSFGRARVLYETGSRTAEAGW-DFVPASGELLFEAREKMKSLYIDILDDNLPEG 4370
Cdd:TIGR00845  529 IFTFEEDVFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTARGGGkDFEDTCGELEFENDETEKTIRVKIVDDEEYEK 608


                   ....*...
gi 1039743058 4371 PEEFVLAI 4378
Cdd:TIGR00845  609 NDTFFIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2898-3098 1.34e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 74.83  E-value: 1.34e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2898 TEGNLAEPESDFIPVVGSLVLEEGETTAAISITVLEDDIPELKEYFLVNLTHV------DLIMAPLTSSPPRLDSEgLTA 2971
Cdd:TIGR00845  439 TEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLrvgsedGILEANHVSAVAQLASP-NTA 517

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2972 QIVIDANDGAqGMIEWQRNRFEVNETDGVVTLVAQRSRAALGQVSLFMYAQNLEAQAGL-DYMCTPQILHFTDGERFKHV 3050
Cdd:TIGR00845  518 TVTILDDDHA-GIFTFEEDVFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTARGGGkDFEDTCGELEFENDETEKTI 596

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1039743058 3051 DVMILDDDMPEGDERFQLLLTNPSPGLELGKNTIALITVLANDDGPGV 3098
Cdd:TIGR00845  597 RVKIVDDEEYEKNDTFFIELGEPRWAKRGIKAALLLNETITDDDQKLT 644
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1751-1832 1.49e-12

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 66.12  E-value: 1.49e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  1751 PHITVQEEDGEIRLLVIRAQGLLGRVTVGFRTVSLTAFSPEDYQSTAGTLEFQSGERYKYIFVNITDNSIPELEKSFKVE 1830
Cdd:smart00237    9 PVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDETFYVR 88


                    ..
gi 1039743058  1831 LL 1832
Cdd:smart00237   89 LS 90
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2151-2346 1.75e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 74.44  E-value: 1.75e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2151 HVAENHVGPIINVTRTGGTFAD-VSVKFKAVPITAAAGEDYSIASSDVVLLEGETTKAVPIYIINDIYPELEETFLVQLL 2229
Cdd:TIGR00845  410 TCLENCGTVALTVVRRGGDLTNtVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLS 489

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2230 N---ETTGGATLGPLREAVITIEA---------SDDPYGLFGFQNTKFIVEEpefNSVRVNVPIIRNSGTLGNVTVQWvA 2297
Cdd:TIGR00845  490 NlrvGSEDGILEANHVSAVAQLASpntatvtilDDDHAGIFTFEEDVFHVSE---SIGIMEVKVLRTSGARGTVIVPY-R 565

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039743058 2298 IINGQfATG---DLRVVSGNVTFAPGETIQTLLLEVLADDVPEIEEVVQVQL 2346
Cdd:TIGR00845  566 TVEGT-ARGggkDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1649-1831 2.58e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 73.67  E-value: 2.58e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1649 DFANASGTITFLPWQRSEVLNLYVLDEDMPELNEYFRVTL--VSAVPGDGKLGSTPISGASIDPEKETTGITVKASDHPy 1726
Cdd:TIGR00845  449 DYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLsnLRVGSEDGILEANHVSAVAQLASPNTATVTILDDDHA- 527

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1727 GLMQFstglppqpEDSmslpassvpHITVQEEDGEIRLLVIRAQGLLGRVTVGFRTVSLTA-FSPEDYQSTAGTLEFQSG 1805
Cdd:TIGR00845  528 GIFTF--------EED---------VFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTArGGGKDFEDTCGELEFEND 590

                          170       180
                   ....*....|....*....|....*.
gi 1039743058 1806 ERYKYIFVNITDNSIPELEKSFKVEL 1831
Cdd:TIGR00845  591 ETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1028-1231 2.57e-11

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 70.59  E-value: 2.57e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1028 NDDP--VYFaEPCVLRVQE--GETANFTVLRNGSVDGACTVQYATVDGKASGEEgDFAPVEKgeTLVFEVGSREQSISVH 1103
Cdd:TIGR00845  396 NDPVskIFF-EPGHYTCLEncGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGS-DYEFTEG--TLVFKPGETQKEFRIG 471

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1104 VKDDGIPETDEPFYIVLFN---STGDTVVYEYG-----------VATVIIeANDDPNGVFSLE-PIDKAVEEGKTNAFWI 1168
Cdd:TIGR00845  472 IIDDDIFEEDEHFYVRLSNlrvGSEDGILEANHvsavaqlaspnTATVTI-LDDDHAGIFTFEeDVFHVSESIGIMEVKV 550

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039743058 1169 LRHRGHFGNVSVAWQLFQNASLQPGQEFYETSGTVNFTDGEETKPVILRAFPDRIPEFNE-FYI 1231
Cdd:TIGR00845  551 LRTSGARGTVIVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDtFFI 614
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2626-2698 9.46e-11

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 61.12  E-value: 9.46e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039743058  2626 QTSVELVIYRTGGSLGQVMVEWRVVGGTATEGLDFMGAGDILTFAEGETKKMAILTILDDSEPEDNESILVRL 2698
Cdd:smart00237   17 DGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDETFYVRL 89
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2992-3071 1.38e-10

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 60.73  E-value: 1.38e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  2992 FEVNETDGVVTLVAQRSRAALGQVSLFMYAQNLEAQAGLDYMCTPQILHFTDGERFKHVDVMILDDDMPEGDERFQLLLT 3071
Cdd:smart00237   11 YTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDETFYVRLS 90
Calx-beta pfam03160
Calx-beta domain;
2992-3071 2.03e-10

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 59.96  E-value: 2.03e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2992 FEVNETDGVVTLVAQRSRAALGQVSLFMYA-QNLEAQAGLDYMCTPQILHFTDGERFKHVDVMILDDDMPEGDERFQLLL 3070
Cdd:pfam03160   11 YQVSENDGVAEVCVVRMSGTLRRTVVVPYRtEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVYEGDENFFVLL 90


                   .
gi 1039743058 3071 T 3071
Cdd:pfam03160   91 S 91
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 3026-3197 3.94e-10

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 66.74  E-value: 3.94e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 3026 AQAGLDYMCTPQILHFTDGERFKHVDVMILDDDMPEGDERFQLLLTNPSPGLE--------------LGKNTIALITVLa 3091
Cdd:TIGR00845  444 ANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSEdgileanhvsavaqLASPNTATVTIL- 522

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 3092 NDDGPGVLSFNNSghiflreptSLYVQESVAVLVIVREPAQGLFGTVAVQFVVTEVNSSTESKDLSPSKGFIVLEEGVRS 3171
Cdd:TIGR00845  523 DDDHAGIFTFEED---------VFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTARGGGKDFEDTCGELEFENDETE 593

                          170       180
                   ....*....|....*....|....*.
gi 1039743058 3172 KTLRISAILDTEPEMDEHFVCTLFNP 3197
Cdd:TIGR00845  594 KTIRVKIVDDEEYEKNDTFFIELGEP 619
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 3610-3766 7.65e-09

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 62.50  E-value: 7.65e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 3610 SDFIPSLGELIFEPGDKEAIIAVNVLDDTVPEKEESFRVQLKSPRGGAEIGINSSVR--------------VTVLANDGA 3675
Cdd:TIGR00845  448 SDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSEDGILEANHvsavaqlaspntatVTILDDDHA 527

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 3676 yGVVAFAqnslHKQLEELERDSLVTLNVERLRGTHGRI-----TVAWEAAGSVSDVFPTSGVISFTEDQAMSMITLTVLA 3750
Cdd:TIGR00845  528 -GIFTFE----EDVFHVSESIGIMEVKVLRTSGARGTVivpyrTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVD 602

                          170
                   ....*....|....*.
gi 1039743058 3751 DDLPELSEAVVVTLTQ 3766
Cdd:TIGR00845  603 DEEYEKNDTFFIELGE 618
Calx-beta pfam03160
Calx-beta domain;
2627-2698 1.68e-08

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 54.56  E-value: 1.68e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039743058 2627 TSVELVIYRTGGSL-GQVMVEWRVVGGTATEGLDFMGAGDILTFAEGETKKMAILTILDDSEPEDNESILVRL 2698
Cdd:pfam03160   18 GVAEVCVVRMSGTLrRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVYEGDENFFVLL 90
Calx-beta pfam03160
Calx-beta domain;
2012-2101 1.85e-08

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 54.56  E-value: 1.85e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2012 SVEEATQNVTLSIIRLKG-LMGEVAVSYATIDDMekppyfppnlarATQGGDYISASGLALFRANQTEATITISILDDAE 2090
Cdd:pfam03160   12 QVSENDGVAEVCVVRMSGtLRRTVVVPYRTEDGT------------ATAGDDYEPVEGELVFGPGETEKCINVTIIDDDV 79

                           90
                   ....*....|.
gi 1039743058 2091 PERSESVFIEL 2101
Cdd:pfam03160   80 YEGDENFFVLL 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2012-2101 2.74e-08

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 54.18  E-value: 2.74e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  2012 SVEEATQNVTLSIIRLKGLMGEVAVSYATIDDMekppyfppnlarATQGGDYISASGLALFRANQTEATITISILDDAEP 2091
Cdd:smart00237   12 TVSESDGEVEVCVVRTGGARGPVVVPYSTEDGT------------ATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIY 79

                            90
                    ....*....|
gi 1039743058  2092 ERSESVFIEL 2101
Cdd:smart00237   80 EKDETFYVRL 89
Calx-beta pfam03160
Calx-beta domain;
1031-1120 3.17e-08

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 53.79  E-value: 3.17e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1031 PVYFAEPCVLRVQE--GETANFTVLRNGSVDGACTVQYATVDGKASGEEgDFAPVEkgETLVFEVGSREQSISVHVKDDG 1108
Cdd:pfam03160    2 GVIGFEPPTYQVSEndGVAEVCVVRMSGTLRRTVVVPYRTEDGTATAGD-DYEPVE--GELVFGPGETEKCINVTIIDDD 78

                           90
                   ....*....|..
gi 1039743058 1109 IPETDEPFYIVL 1120
Cdd:pfam03160   79 VYEGDENFFVLL 90
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 79-262 2.04e-07

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 57.49  E-value: 2.04e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058   79 LVIERIGEPANVTAIVSLSGEDT-----GDFFDTYAAAFIPARGTNRTVYIAVCDDDLPEPDETFTFHLT---------- 143
Cdd:TIGR00845  420 LTVVRRGGDLTNTVYVDYRTEDGtanagSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSnlrvgsedgi 499

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  144 LQKPSANVK--LGWPRAASVTILSNDNAfGIISFsTPSSISVIEPRSRnasVPLTLIREKGTYGMVTVTF-DVSGGPNPP 220
Cdd:TIGR00845  500 LEANHVSAVaqLASPNTATVTILDDDHA-GIFTF-EEDVFHVSESIGI---MEVKVLRTSGARGTVIVPYrTVEGTARGG 574

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1039743058  221 EEDLNPVRGNITFPPGRATVIYNVTVLDDEVPENDELFLIQL 262
Cdd:TIGR00845  575 GKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 3818-4030 2.19e-07

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 57.49  E-value: 2.19e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 3818 ENITVVQLHIVRDKGlfgDISIHLIAkpnfllhinNQATED------EDFVLQDSVIIMKENIKETHAEVAILPDEVPEL 3891
Cdd:TIGR00845  413 ENCGTVALTVVRRGG---DLTNTVYV---------DYRTEDgtanagSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEE 480

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 3892 DEGLIVTIAAVNLVNPNFPAEQPRVQR------PRMESAEILieeNDDPRGIFNF-----HVVRDVGgviiahegpppln 3960
Cdd:TIGR00845  481 DEHFYVRLSNLRVGSEDGILEANHVSAvaqlasPNTATVTIL---DDDHAGIFTFeedvfHVSESIG------------- 544

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039743058 3961 VLQVPVVRMAGTFETVNVYWKATPDSA--GLEDFQPSHGMLQFADGQVIAPILVTIIDDSEFELLETFTISL 4030
Cdd:TIGR00845  545 IMEVKVLRTSGARGTVIVPYRTVEGTArgGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1032-1120 3.08e-07

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 51.10  E-value: 3.08e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  1032 VYFAEPcVLRVQEGE-TANFTVLRNGSVDGACTVQYATVDGKASGEEgDFAPVEKgeTLVFEVGSREQSISVHVKDDGIP 1110
Cdd:smart00237    4 VGFEQP-VYTVSESDgEVEVCVVRTGGARGPVVVPYSTEDGTATAGS-DYEPVPG--ELTFPPGETEKEIRIKIIDDDIY 79

                            90
                    ....*....|
gi 1039743058  1111 ETDEPFYIVL 1120
Cdd:smart00237   80 EKDETFYVRL 89
LamGL smart00560
LamG-like jellyroll fold domain;
1378-1515 6.32e-07

LamG-like jellyroll fold domain;


Pssm-ID: 214722 [Multi-domain]  Cd Length: 133  Bit Score: 51.65  E-value: 6.32e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  1378 FTFSAWVMPNANTNGFLIAKDdshgsiYYGVKIQTNETHVTLSLHYKTFGSNVTYIaksTVMKYLEEGVWLHVLIILD-- 1455
Cdd:smart00560    3 FTLEAWVKLESAGGSQPIITG------AAVAQPTISEKALTFFLRAKSVQGWQTAR---TGATADWIGVWVHLAGVYDgg 73

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039743058  1456 DGIIEFYLDGkamprgikSLKGEAITDGPGI-------LRIGAGMDGGARFTGWMQDVRTYERKLTP 1515
Cdd:smart00560   74 AGKLSLYVNG--------VEVATSETQPSPSsgnlpqgGRILLGGAGGENFSGRLDEVRVYNRALTA 132
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 3961-4030 6.66e-07

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 49.95  E-value: 6.66e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039743058  3961 VLQVPVVRMAGTFETVNVYWKATPDSA-GLEDFQPSHGMLQFADGQVIAPILVTIIDDSEFELLETFTISL 4030
Cdd:smart00237   19 EVEVCVVRTGGARGPVVVPYSTEDGTAtAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDETFYVRL 89
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 273-515 7.06e-07

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 55.95  E-value: 7.06e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  273 ASRSSVEIIVKKNDSP--VNFMQSVYVVPEDDHVLTIPVLRgkdsDGnliGSDETQVSIRYKvmTWDSTAHAQQNVDFID 350
Cdd:TIGR00845  384 VSMHEVATDDEENDPVskIFFEPGHYTCLENCGTVALTVVR----RG---GDLTNTVYVDYR--TEDGTANAGSDYEFTE 454

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  351 lqpdTTLVFPPFVHESHLKFQIIDDLIPEIAESFHI------------MLLKNTLQGDAVLMGPSTVQVTIKPNDKPyGV 418
Cdd:TIGR00845  455 ----GTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVrlsnlrvgsedgILEANHVSAVAQLASPNTATVTILDDDHA-GI 529

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  419 LSFNSILFERpviidedTASSSRFeEIAVVRNGGTHGNVSVSWVLTRNSSDPSPVtaDITPASGTLQFAQGQMLAPISLV 498
Cdd:TIGR00845  530 FTFEEDVFHV-------SESIGIM-EVKVLRTSGARGTVIVPYRTVEGTARGGGK--DFEDTCGELEFENDETEKTIRVK 599

                          250
                   ....*....|....*..
gi 1039743058  499 VFDDDLPEEAEAYLLTI 515
Cdd:TIGR00845  600 IVDDEEYEKNDTFFIEL 616
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2141-2229 3.05e-06

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 48.40  E-value: 3.05e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  2141 GTVQLSATSVHVAENhVGPI-INVTRTGGTFADVSVKFKAVPITAAAGEDYSIASSDVVLLEGETTKAVPIYIINDIYPE 2219
Cdd:smart00237    2 GSVGFEQPVYTVSES-DGEVeVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYE 80

                            90
                    ....*....|
gi 1039743058  2220 LEETFLVQLL 2229
Cdd:smart00237   81 KDETFYVRLS 90
PTX cd00152
Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their ...
 1377-1521 3.18e-06

Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated in innate immunity. CRP binds to ligands containing phosphocholine, SAP binds to amyloid fibrils, DNA, chromatin, fibronectin, C4-binding proteins and glycosaminoglycans. "Long" pentraxins have N-terminal extensions to the common pentraxin domain; one group, the neuronal pentraxins, may be involved in synapse formation and remodeling, and they may also be able to form heteromultimers.


Pssm-ID: 238086  Cd Length: 201  Bit Score: 51.12  E-value: 3.18e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1377 NFTFSAWVMPNANTNGFLIakddshgsIYYGVKIQTNEthvtLSLHYKTFGSNVTYIAKSTVMKYLEE--GVWLHVLIIL 1454
Cdd:cd00152     32 AFTLCLWVYTDLSTREYSL--------FSYATKGQDNE----LLLYKEKDGGYSLYIGGKEVTFKVPEsdGAWHHICVTW 99

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039743058 1455 D--DGIIEFYLDGKAMPRGIKSlKGEAITDGPGIL------RIGAGMDGGARFTGWMQDVRTYERKLTPEEIYEL 1521
Cdd:cd00152    100 EstSGIAELWVNGKLSVRKSLK-KGYTVGPGGSIIlgqeqdSYGGGFDATQSFVGEISDVNMWDSVLSPEEIKNV 173
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 3609-3650 5.65e-06

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 47.63  E-value: 5.65e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1039743058  3609 QSDFIPSLGELIFEPGDKEAIIAVNVLDDTVPEKEESFRVQL 3650
Cdd:smart00237   48 GSDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDETFYVRL 89
Calx-beta pfam03160
Calx-beta domain;
2141-2228 5.70e-06

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 47.63  E-value: 5.70e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2141 GTVQLSATSVHVAENhVGPI-INVTRTGGTFA-DVSVKFKAVPITAAAGEDYSIASSDVVLLEGETTKAVPIYIINDIYP 2218
Cdd:pfam03160    2 GVIGFEPPTYQVSEN-DGVAeVCVVRMSGTLRrTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVY 80

                           90
                   ....*....|
gi 1039743058 2219 ELEETFLVQL 2228
Cdd:pfam03160   81 EGDENFFVLL 90
Calx-beta pfam03160
Calx-beta domain;
3961-4030 6.11e-06

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 47.24  E-value: 6.11e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039743058 3961 VLQVPVVRMAGTFE-TVNVYWKATPDSA-GLEDFQPSHGMLQFADGQVIAPILVTIIDDSEFELLETFTISL 4030
Cdd:pfam03160   19 VAEVCVVRMSGTLRrTVVVPYRTEDGTAtAGDDYEPVEGELVFGPGETEKCINVTIIDDDVYEGDENFFVLL 90
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 3419-3460 6.86e-05

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 42.84  E-value: 6.86e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1039743058 3419 FAWHQTLPVRGVLGMALFSRGGSVFLAISQANIRqtSLLFTW 3460
Cdd:pfam03736    2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGD--SVIYRW 41
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 289-389 1.46e-04

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 43.40  E-value: 1.46e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058   289 VNFMQSVYVVPEDDHVLTIPVLRGKDSDGNligsdetqVSIRYKvmTWDSTAHAQQnvDFIDLqpDTTLVFPPFVHESHL 368
Cdd:smart00237    4 VGFEQPVYTVSESDGEVEVCVVRTGGARGP--------VVVPYS--TEDGTATAGS--DYEPV--PGELTFPPGETEKEI 69

                            90       100
                    ....*....|....*....|.
gi 1039743058   369 KFQIIDDLIPEIAESFHIMLL 389
Cdd:smart00237   70 RIKIIDDDIYEKDETFYVRLS 90
Calx-beta pfam03160
Calx-beta domain;
3610-3650 1.52e-04

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 43.39  E-value: 1.52e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1039743058 3610 SDFIPSLGELIFEPGDKEAIIAVNVLDDTVPEKEESFRVQL 3650
Cdd:pfam03160   50 DDYEPVEGELVFGPGETEKCINVTIIDDDVYEGDENFFVLL 90
Calx-beta pfam03160
Calx-beta domain;
4423-4511 3.58e-04

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 42.24  E-value: 3.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 4423 GIIEFDPkyTDISVEEDAGVITLPVLRLHGTY-GHVSADFSSRGFSAVPGG-YVLHGSSVTFQHGQNLSFINVSIIDDNG 4500
Cdd:pfam03160    2 GVIGFEP--PTYQVSENDGVAEVCVVRMSGTLrRTVVVPYRTEDGTATAGDdYEPVEGELVFGPGETEKCINVTIIDDDV 79

                           90
                   ....*....|.
gi 1039743058 4501 SEFEKQFEILL 4511
Cdd:pfam03160   80 YEGDENFFVLL 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 4423-4511 3.80e-04

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 42.24  E-value: 3.80e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  4423 GIIEFD-PKYTdisVEEDAGVITLPVLRLHGTYGHVSADFSSRGFSAVPGG-YVLHGSSVTFQHGQNLSFINVSIIDDNG 4500
Cdd:smart00237    2 GSVGFEqPVYT---VSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSdYEPVPGELTFPPGETEKEIRIKIIDDDI 78

                            90
                    ....*....|.
gi 1039743058  4501 SEFEKQFEILL 4511
Cdd:smart00237   79 YEKDETFYVRL 89
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 4418-4657 4.50e-04

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 46.71  E-value: 4.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 4418 NDNAEGIIeFDP-KYTdisVEEDAGVITLPVLRLHGTYG-HVSADFSSRGFSAVPGG-YVLHGSSVTFQHGQNLSFINVS 4494
Cdd:TIGR00845  396 NDPVSKIF-FEPgHYT---CLENCGTVALTVVRRGGDLTnTVYVDYRTEDGTANAGSdYEFTEGTLVFKPGETQKEFRIG 471

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 4495 IIDDNGSEFEKQFEILL--------------IGATGGAILGRHLVSKITIAKSDSPfGIIRFlNQSKISLPNPSSTMALH 4560
Cdd:TIGR00845  472 IIDDDIFEEDEHFYVRLsnlrvgsedgileaNHVSAVAQLASPNTATVTILDDDHA-GIFTF-EEDVFHVSESIGIMEVK 549

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 4561 LVleRTGGLLGEIQVSWEVVGPDAEEplppHNGDFADpVSGTVSFGDGEgGVRSIILRVCPHEETEAEETFIVQLKPLRE 4640
Cdd:TIGR00845  550 VL--RTSGARGTVIVPYRTVEGTARG----GGKDFED-TCGELEFENDE-TEKTIRVKIVDDEEYEKNDTFFIELGEPRW 621

                          250       260
                   ....*....|....*....|
gi 1039743058 4641 AKLD---PRAKAVTLTGASK 4657
Cdd:TIGR00845  622 AKRGikaALLLNETITDDDQ 641
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 707-1001 4.61e-04

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 46.71  E-value: 4.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  707 RDGTDGQATVYWSLRPSGFNSKAVTldDAGPFNGSVVFLSGQNETSINITVKGDDIPELNET--VTLSLDRVSVDSDVLK 784
Cdd:TIGR00845  424 RRGGDLTNTVYVDYRTEDGTANAGS--DYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHfyVRLSNLRVGSEDGILE 501

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  785 SGYTSR----------DLIILEnDDPGGIFEFSYDSRgpYVIKEGDAVELRITRSRGSLVKQFLRFHVE---PRESNE-F 850
Cdd:TIGR00845  502 ANHVSAvaqlaspntaTVTILD-DDHAGIFTFEEDVF--HVSESIGIMEVKVLRTSGARGTVIVPYRTVegtARGGGKdF 578

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  851 YGNMGVLEFTPGEREVVITLLTRLDGTPELDEHFWVILSSHGERESKLGCATLVNITILKNDYPHGIIEFVSDGLSASIK 930
Cdd:TIGR00845  579 EDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKAALLLNETITDDDQKLTSKEEEERRIAEMGK 658

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039743058  931 ESKGEDIyhAVYGVIRTRGNFGAVnVSWMVSpdfTQDVFPVQGTVCFGDQeFFKNITVYSLVDEIPEEMEE 1001
Cdd:TIGR00845  659 PRLGEHT--KLEVIIEESYEFKST-VDKLIK---KTNLALVVGTHSWREQ-FIEAITVSAGDDDDDDEDGE 722
Calx-beta pfam03160
Calx-beta domain;
171-262 4.90e-04

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 41.85  E-value: 4.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  171 GIISFStPSSISVIEprsRNASVPLTLIREKGTY-GMVTVTFDVSGGPNPPEEDLNPVRGNITFPPGRATVIYNVTVLDD 249
Cdd:pfam03160    2 GVIGFE-PPTYQVSE---NDGVAEVCVVRMSGTLrRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDD 77

                           90
                   ....*....|...
gi 1039743058  250 EVPENDELFLIQL 262
Cdd:pfam03160   78 DVYEGDENFFVLL 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 171-262 1.58e-03

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 40.70  E-value: 1.58e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058   171 GIISFsTPSSISVIEprsrNA-SVPLTLIREKGTYGMVTVTFDVSGGPNPPEEDLNPVRGNITFPPGRATVIYNVTVLDD 249
Cdd:smart00237    2 GSVGF-EQPVYTVSE----SDgEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDD 76

                            90
                    ....*....|...
gi 1039743058   250 EVPENDELFLIQL 262
Cdd:smart00237   77 DIYEKDETFYVRL 89
Calx-beta pfam03160
Calx-beta domain;
1596-1688 1.60e-03

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 40.70  E-value: 1.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1596 GLFGFTGACIPEMTEEGSTVSCVVeRTRGAL-GYVHV-FYTISQIESEGinylvDDFANASGTITFLPWQRSEVLNLYVL 1673
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVV-RMSGTLrRTVVVpYRTEDGTATAG-----DDYEPVEGELVFGPGETEKCINVTII 75

                           90
                   ....*....|....*
gi 1039743058 1674 DEDMPELNEYFRVTL 1688
Cdd:pfam03160   76 DDDVYEGDENFFVLL 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 4057-4148 3.82e-03

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 39.55  E-value: 3.82e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  4057 GIFGFEKKTVMV---DGPllsddpdsyVTLTVVRSPGGKGAVRLHWAIEE---KAKDDLSPLNGTLYFDETESQKSVILH 4130
Cdd:smart00237    2 GSVGFEQPVYTVsesDGE---------VEVCVVRTGGARGPVVVPYSTEDgtaTAGSDYEPVPGELTFPPGETEKEIRIK 72

                            90
                    ....*....|....*...
gi 1039743058  4131 TLKDGMVGEDRRFIIELT 4148
Cdd:smart00237   73 IIDDDIYEKDETFYVRLS 90
 
Name Accession Description Interval E-value
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 1369-1518 2.77e-17

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 81.66  E-value: 2.77e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1369 PFRNNTIANFTFSAWVMPNANTNGF-LIAKDDSHGSIYYGVKiQTNETHVTLslhYKTFGSNVTYIAKSTVmkylEEGVW 1447
Cdd:pfam13385   10 PDALLPTSDFTVSAWVKPDSLPGWArAIISSSGGGGYSLGLD-GDGRLRFAV---NGGNGGWDTVTSGASV----PLGQW 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039743058 1448 LHVLIILDDGIIEFYLDGKAMPRGikSLKGEAITDGPGILRIGAGMDGGARFTGWMQDVRTYERKLTPEEI 1518
Cdd:pfam13385   82 THVAVTYDGGTLRLYVNGVLVGSS--TLTGGPPPGTGGPLYIGRSPGGDDYFNGLIDEVRIYDRALSAAEI 150
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 4291-4379 7.49e-17

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 78.45  E-value: 7.49e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  4291 GRFSFSHEQLHVSEAAQRVNVTVVRSGGSFGRARVLYETGSRTAEAGWDFVPASGELLFEAREKMKSLYIDILDDNLPEG 4370
Cdd:smart00237    2 GSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYEK 81


                    ....*....
gi 1039743058  4371 PEEFVLAIT 4379
Cdd:smart00237   82 DETFYVRLS 90
Calx-beta pfam03160
Calx-beta domain;
4291-4379 4.82e-16

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 76.13  E-value: 4.82e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 4291 GRFSFSHEQLHVSEAAQRVNVTVVRSGGSFGRA-RVLYETGSRTAEAGWDFVPASGELLFEAREKMKSLYIDILDDNLPE 4369
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVVRMSGTLRRTvVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVYE 81

                           90
                   ....*....|
gi 1039743058 4370 GPEEFVLAIT 4379
Cdd:pfam03160   82 GDENFFVLLS 91
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 4275-4511 1.66e-14

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 80.99  E-value: 1.66e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 4275 ASVSARITMVASDAPYGRFSFSHEQLHVSEAAQRVNVTVVRSGGSFGR-ARVLYETGSRTAEAGWDFVPASGELLFEARE 4353
Cdd:TIGR00845  384 VSMHEVATDDEENDPVSKIFFEPGHYTCLENCGTVALTVVRRGGDLTNtVYVDYRTEDGTANAGSDYEFTEGTLVFKPGE 463

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 4354 KMKSLYIDILDDNLPEGPEEFVLAITRVDLQgrgydftiQENGLQIDQPPE----IGNISIVRIIIMKNDNAeGIIEFDP 4429
Cdd:TIGR00845  464 TQKEFRIGIIDDDIFEEDEHFYVRLSNLRVG--------SEDGILEANHVSavaqLASPNTATVTILDDDHA-GIFTFEE 534

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 4430 KYTDISveEDAGVITLPVLRLHGTYGHVSADFSSRGFSAVPGG--YVLHGSSVTFQHGQNLSFINVSIIDDNGSEFEKQF 4507
Cdd:TIGR00845  535 DVFHVS--ESIGIMEVKVLRTSGARGTVIVPYRTVEGTARGGGkdFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTF 612


                   ....
gi 1039743058 4508 EILL 4511
Cdd:TIGR00845  613 FIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2628-2812 2.15e-14

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 80.61  E-value: 2.15e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2628 SVELVIYRTGGSLGQ-VMVEWRVVGGTATEGLDFMGAGDILTFAEGETKKMAILTILDDSEPEDNESILVRL----VATE 2702
Cdd:TIGR00845  417 TVALTVVRRGGDLTNtVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLsnlrVGSE 496

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2703 GGSRI---------LPSSDTVTVNILANDNvAGIVSFQTASRSVIGHEGEMlQFHVVRTPPGRGNVTVNWKVV---GQNL 2770
Cdd:TIGR00845  497 DGILEanhvsavaqLASPNTATVTILDDDH-AGIFTFEEDVFHVSESIGIM-EVKVLRTSGARGTVIVPYRTVegtARGG 574

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1039743058 2771 EVNFANFTGQLFFSEGTLNKTIFVHLLDDNIPEEKEVYQVVL 2812
Cdd:TIGR00845  575 GKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1752-1974 2.71e-14

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 80.22  E-value: 2.71e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1752 HITVQEEDGEIRLLVIRAQGLLGR-VTVGFRTVSLTAFSPEDYQSTAGTLEFQSGERYKYIFVNITDNSIPELEKSFKVE 1830
Cdd:TIGR00845  408 HYTCLENCGTVALTVVRRGGDLTNtVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVR 487

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1831 LLNLDGGVSDLFRVDGSGSGEadtdfflppvlphASLGVASQILVTIAASDHAhGVFEFSPESLFVSgtepeDGYSTVVL 1910
Cdd:TIGR00845  488 LSNLRVGSEDGILEANHVSAV-------------AQLASPNTATVTILDDDHA-GIFTFEEDVFHVS-----ESIGIMEV 548

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039743058 1911 NVTRTRGALSAVTLQ-WKVDSDLDG---DLAITSGNITFETGQRIASITVEILSDEEPELDKALTVSI 1974
Cdd:TIGR00845  549 KVLRTSGARGTVIVPyRTVEGTARGggkDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1907-2101 4.94e-14

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 79.45  E-value: 4.94e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1907 TVVLNVTRTRGALS-AVTLQWKVDsdlDG------DLAITSGNITFETGQRIASITVEILSDEEPELDKALTVSILNVSS 1979
Cdd:TIGR00845  417 TVALTVVRRGGDLTnTVYVDYRTE---DGtanagsDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRV 493

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1980 GS---------------LGVLTNATLTILaSDDPYGVFIFPNKTrpLSVEEATQNVTLSIIRLKGLMGEVAVSYATIDDM 2044
Cdd:TIGR00845  494 GSedgileanhvsavaqLASPNTATVTIL-DDDHAGIFTFEEDV--FHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGT 570

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1039743058 2045 ekppyfppnlarATQGG-DYISASGLALFRANQTEATITISILDDAEPERSESVFIEL 2101
Cdd:TIGR00845  571 ------------ARGGGkDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
Calx-beta pfam03160
Calx-beta domain;
1751-1831 1.01e-13

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 69.59  E-value: 1.01e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1751 PHITVQEEDGEIRLLVIRAQGLLGR-VTVGFRTVSLTAFSPEDYQSTAGTLEFQSGERYKYIFVNITDNSIPELEKSFKV 1829
Cdd:pfam03160    9 PTYQVSENDGVAEVCVVRMSGTLRRtVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVYEGDENFFV 88


                   ..
gi 1039743058 1830 EL 1831
Cdd:pfam03160   89 LL 90
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2518-2698 1.67e-13

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 77.52  E-value: 1.67e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2518 GQAVAGSDYEPvTRQWAVILEGDEFANLTVSVLPDDAPEMDESFLISLLEVHL-----MNISDSFKNQPTIGHPNTSAVV 2592
Cdd:TIGR00845  442 GTANAGSDYEF-TEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVgsedgILEANHVSAVAQLASPNTATVT 520

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2593 IgLNGDAFGVFiiysvspnTSEDGLcVEVQEQPQTsVELVIYRTGGSLGQVMVEWRVVGGTATEGL-DFMGAGDILTFAE 2671
Cdd:TIGR00845  521 I-LDDDHAGIF--------TFEEDV-FHVSESIGI-MEVKVLRTSGARGTVIVPYRTVEGTARGGGkDFEDTCGELEFEN 589

                          170       180
                   ....*....|....*....|....*..
gi 1039743058 2672 GETKKMAILTILDDSEPEDNESILVRL 2698
Cdd:TIGR00845  590 DETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 4224-4378 1.03e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 75.21  E-value: 1.03e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 4224 EFVETSGQLTMLDGQTAATVVIQALNDDIPEEKCHYEFQLTEISEGR---MLHEASVSAR---------ITMVASDAPYG 4291
Cdd:TIGR00845  449 DYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSedgILEANHVSAVaqlaspntaTVTILDDDHAG 528

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 4292 RFSFSHEQLHVSEAAQRVNVTVVRSGGSFGRARVLYETGSRTAEAGW-DFVPASGELLFEAREKMKSLYIDILDDNLPEG 4370
Cdd:TIGR00845  529 IFTFEEDVFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTARGGGkDFEDTCGELEFENDETEKTIRVKIVDDEEYEK 608


                   ....*...
gi 1039743058 4371 PEEFVLAI 4378
Cdd:TIGR00845  609 NDTFFIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1996-2228 1.11e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 74.83  E-value: 1.11e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1996 DDPYGVFIFPNKtrpLSVEEATQNVTLSIIRLKGLMGE-VAVSYATIDdmekppyfppnlARATQGGDYISASGLALFRA 2074
Cdd:TIGR00845  397 DPVSKIFFEPGH---YTCLENCGTVALTVVRRGGDLTNtVYVDYRTED------------GTANAGSDYEFTEGTLVFKP 461

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2075 NQTEATITISILDDAEPERSESVFIELFNSSLVDKVQNRPIPHSPRLGPKVETVAHLVIVANDDAFGTVQLSATSVHVAE 2154
Cdd:TIGR00845  462 GETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSEDGILEANHVSAVAQLASPNTATVTILDDDHAGIFTFEEDVFHVSE 541

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039743058 2155 NhVGPI-INVTRTGGTFADVSVKFKAVPITAAAG-EDYSIASSDVVLLEGETTKAVPIYIINDIYPELEETFLVQL 2228
Cdd:TIGR00845  542 S-IGIMeVKVLRTSGARGTVIVPYRTVEGTARGGgKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2898-3098 1.34e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 74.83  E-value: 1.34e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2898 TEGNLAEPESDFIPVVGSLVLEEGETTAAISITVLEDDIPELKEYFLVNLTHV------DLIMAPLTSSPPRLDSEgLTA 2971
Cdd:TIGR00845  439 TEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLrvgsedGILEANHVSAVAQLASP-NTA 517

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2972 QIVIDANDGAqGMIEWQRNRFEVNETDGVVTLVAQRSRAALGQVSLFMYAQNLEAQAGL-DYMCTPQILHFTDGERFKHV 3050
Cdd:TIGR00845  518 TVTILDDDHA-GIFTFEEDVFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTARGGGkDFEDTCGELEFENDETEKTI 596

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1039743058 3051 DVMILDDDMPEGDERFQLLLTNPSPGLELGKNTIALITVLANDDGPGV 3098
Cdd:TIGR00845  597 RVKIVDDEEYEKNDTFFIELGEPRWAKRGIKAALLLNETITDDDQKLT 644
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1751-1832 1.49e-12

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 66.12  E-value: 1.49e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  1751 PHITVQEEDGEIRLLVIRAQGLLGRVTVGFRTVSLTAFSPEDYQSTAGTLEFQSGERYKYIFVNITDNSIPELEKSFKVE 1830
Cdd:smart00237    9 PVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDETFYVR 88


                    ..
gi 1039743058  1831 LL 1832
Cdd:smart00237   89 LS 90
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 2151-2346 1.75e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 74.44  E-value: 1.75e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2151 HVAENHVGPIINVTRTGGTFAD-VSVKFKAVPITAAAGEDYSIASSDVVLLEGETTKAVPIYIINDIYPELEETFLVQLL 2229
Cdd:TIGR00845  410 TCLENCGTVALTVVRRGGDLTNtVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLS 489

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2230 N---ETTGGATLGPLREAVITIEA---------SDDPYGLFGFQNTKFIVEEpefNSVRVNVPIIRNSGTLGNVTVQWvA 2297
Cdd:TIGR00845  490 NlrvGSEDGILEANHVSAVAQLASpntatvtilDDDHAGIFTFEEDVFHVSE---SIGIMEVKVLRTSGARGTVIVPY-R 565

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039743058 2298 IINGQfATG---DLRVVSGNVTFAPGETIQTLLLEVLADDVPEIEEVVQVQL 2346
Cdd:TIGR00845  566 TVEGT-ARGggkDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1649-1831 2.58e-12

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 73.67  E-value: 2.58e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1649 DFANASGTITFLPWQRSEVLNLYVLDEDMPELNEYFRVTL--VSAVPGDGKLGSTPISGASIDPEKETTGITVKASDHPy 1726
Cdd:TIGR00845  449 DYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLsnLRVGSEDGILEANHVSAVAQLASPNTATVTILDDDHA- 527

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1727 GLMQFstglppqpEDSmslpassvpHITVQEEDGEIRLLVIRAQGLLGRVTVGFRTVSLTA-FSPEDYQSTAGTLEFQSG 1805
Cdd:TIGR00845  528 GIFTF--------EED---------VFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTArGGGKDFEDTCGELEFEND 590

                          170       180
                   ....*....|....*....|....*.
gi 1039743058 1806 ERYKYIFVNITDNSIPELEKSFKVEL 1831
Cdd:TIGR00845  591 ETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1028-1231 2.57e-11

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 70.59  E-value: 2.57e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1028 NDDP--VYFaEPCVLRVQE--GETANFTVLRNGSVDGACTVQYATVDGKASGEEgDFAPVEKgeTLVFEVGSREQSISVH 1103
Cdd:TIGR00845  396 NDPVskIFF-EPGHYTCLEncGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGS-DYEFTEG--TLVFKPGETQKEFRIG 471

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1104 VKDDGIPETDEPFYIVLFN---STGDTVVYEYG-----------VATVIIeANDDPNGVFSLE-PIDKAVEEGKTNAFWI 1168
Cdd:TIGR00845  472 IIDDDIFEEDEHFYVRLSNlrvGSEDGILEANHvsavaqlaspnTATVTI-LDDDHAGIFTFEeDVFHVSESIGIMEVKV 550

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039743058 1169 LRHRGHFGNVSVAWQLFQNASLQPGQEFYETSGTVNFTDGEETKPVILRAFPDRIPEFNE-FYI 1231
Cdd:TIGR00845  551 LRTSGARGTVIVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDtFFI 614
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2626-2698 9.46e-11

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 61.12  E-value: 9.46e-11
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039743058  2626 QTSVELVIYRTGGSLGQVMVEWRVVGGTATEGLDFMGAGDILTFAEGETKKMAILTILDDSEPEDNESILVRL 2698
Cdd:smart00237   17 DGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDETFYVRL 89
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2992-3071 1.38e-10

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 60.73  E-value: 1.38e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  2992 FEVNETDGVVTLVAQRSRAALGQVSLFMYAQNLEAQAGLDYMCTPQILHFTDGERFKHVDVMILDDDMPEGDERFQLLLT 3071
Cdd:smart00237   11 YTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDETFYVRLS 90
Calx-beta pfam03160
Calx-beta domain;
2992-3071 2.03e-10

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 59.96  E-value: 2.03e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2992 FEVNETDGVVTLVAQRSRAALGQVSLFMYA-QNLEAQAGLDYMCTPQILHFTDGERFKHVDVMILDDDMPEGDERFQLLL 3070
Cdd:pfam03160   11 YQVSENDGVAEVCVVRMSGTLRRTVVVPYRtEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVYEGDENFFVLL 90


                   .
gi 1039743058 3071 T 3071
Cdd:pfam03160   91 S 91
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 3026-3197 3.94e-10

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 66.74  E-value: 3.94e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 3026 AQAGLDYMCTPQILHFTDGERFKHVDVMILDDDMPEGDERFQLLLTNPSPGLE--------------LGKNTIALITVLa 3091
Cdd:TIGR00845  444 ANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSEdgileanhvsavaqLASPNTATVTIL- 522

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 3092 NDDGPGVLSFNNSghiflreptSLYVQESVAVLVIVREPAQGLFGTVAVQFVVTEVNSSTESKDLSPSKGFIVLEEGVRS 3171
Cdd:TIGR00845  523 DDDHAGIFTFEED---------VFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTARGGGKDFEDTCGELEFENDETE 593

                          170       180
                   ....*....|....*....|....*.
gi 1039743058 3172 KTLRISAILDTEPEMDEHFVCTLFNP 3197
Cdd:TIGR00845  594 KTIRVKIVDDEEYEKNDTFFIELGEP 619
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 3610-3766 7.65e-09

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 62.50  E-value: 7.65e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 3610 SDFIPSLGELIFEPGDKEAIIAVNVLDDTVPEKEESFRVQLKSPRGGAEIGINSSVR--------------VTVLANDGA 3675
Cdd:TIGR00845  448 SDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSEDGILEANHvsavaqlaspntatVTILDDDHA 527

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 3676 yGVVAFAqnslHKQLEELERDSLVTLNVERLRGTHGRI-----TVAWEAAGSVSDVFPTSGVISFTEDQAMSMITLTVLA 3750
Cdd:TIGR00845  528 -GIFTFE----EDVFHVSESIGIMEVKVLRTSGARGTVivpyrTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVD 602

                          170
                   ....*....|....*.
gi 1039743058 3751 DDLPELSEAVVVTLTQ 3766
Cdd:TIGR00845  603 DEEYEKNDTFFIELGE 618
Calx-beta pfam03160
Calx-beta domain;
2627-2698 1.68e-08

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 54.56  E-value: 1.68e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039743058 2627 TSVELVIYRTGGSL-GQVMVEWRVVGGTATEGLDFMGAGDILTFAEGETKKMAILTILDDSEPEDNESILVRL 2698
Cdd:pfam03160   18 GVAEVCVVRMSGTLrRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVYEGDENFFVLL 90
Calx-beta pfam03160
Calx-beta domain;
2012-2101 1.85e-08

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 54.56  E-value: 1.85e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2012 SVEEATQNVTLSIIRLKG-LMGEVAVSYATIDDMekppyfppnlarATQGGDYISASGLALFRANQTEATITISILDDAE 2090
Cdd:pfam03160   12 QVSENDGVAEVCVVRMSGtLRRTVVVPYRTEDGT------------ATAGDDYEPVEGELVFGPGETEKCINVTIIDDDV 79

                           90
                   ....*....|.
gi 1039743058 2091 PERSESVFIEL 2101
Cdd:pfam03160   80 YEGDENFFVLL 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2012-2101 2.74e-08

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 54.18  E-value: 2.74e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  2012 SVEEATQNVTLSIIRLKGLMGEVAVSYATIDDMekppyfppnlarATQGGDYISASGLALFRANQTEATITISILDDAEP 2091
Cdd:smart00237   12 TVSESDGEVEVCVVRTGGARGPVVVPYSTEDGT------------ATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIY 79

                            90
                    ....*....|
gi 1039743058  2092 ERSESVFIEL 2101
Cdd:smart00237   80 EKDETFYVRL 89
Calx-beta pfam03160
Calx-beta domain;
1031-1120 3.17e-08

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 53.79  E-value: 3.17e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1031 PVYFAEPCVLRVQE--GETANFTVLRNGSVDGACTVQYATVDGKASGEEgDFAPVEkgETLVFEVGSREQSISVHVKDDG 1108
Cdd:pfam03160    2 GVIGFEPPTYQVSEndGVAEVCVVRMSGTLRRTVVVPYRTEDGTATAGD-DYEPVE--GELVFGPGETEKCINVTIIDDD 78

                           90
                   ....*....|..
gi 1039743058 1109 IPETDEPFYIVL 1120
Cdd:pfam03160   79 VYEGDENFFVLL 90
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 967-1120 5.07e-08

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 59.81  E-value: 5.07e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  967 DVFPVQGTVCFGDQEFFKNITVYSLVDEIPEEMEEFTIILLN--------------ATGGAQTGIRTTASLRILRNDDPV 1032
Cdd:TIGR00845  449 DYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNlrvgsedgileanhVSAVAQLASPNTATVTILDDDHAG 528

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1033 YFA-EPCVLRVQEG-ETANFTVLRNGSVDGACTVQYATVDGKASGEEGDFAPVEkGEtLVFEVGSREQSISVHVKDDGIP 1110
Cdd:TIGR00845  529 IFTfEEDVFHVSESiGIMEVKVLRTSGARGTVIVPYRTVEGTARGGGKDFEDTC-GE-LEFENDETEKTIRVKIVDDEEY 606

                          170
                   ....*....|
gi 1039743058 1111 ETDEPFYIVL 1120
Cdd:TIGR00845  607 EKNDTFFIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 79-262 2.04e-07

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 57.49  E-value: 2.04e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058   79 LVIERIGEPANVTAIVSLSGEDT-----GDFFDTYAAAFIPARGTNRTVYIAVCDDDLPEPDETFTFHLT---------- 143
Cdd:TIGR00845  420 LTVVRRGGDLTNTVYVDYRTEDGtanagSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSnlrvgsedgi 499

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  144 LQKPSANVK--LGWPRAASVTILSNDNAfGIISFsTPSSISVIEPRSRnasVPLTLIREKGTYGMVTVTF-DVSGGPNPP 220
Cdd:TIGR00845  500 LEANHVSAVaqLASPNTATVTILDDDHA-GIFTF-EEDVFHVSESIGI---MEVKVLRTSGARGTVIVPYrTVEGTARGG 574

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1039743058  221 EEDLNPVRGNITFPPGRATVIYNVTVLDDEVPENDELFLIQL 262
Cdd:TIGR00845  575 GKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 3818-4030 2.19e-07

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 57.49  E-value: 2.19e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 3818 ENITVVQLHIVRDKGlfgDISIHLIAkpnfllhinNQATED------EDFVLQDSVIIMKENIKETHAEVAILPDEVPEL 3891
Cdd:TIGR00845  413 ENCGTVALTVVRRGG---DLTNTVYV---------DYRTEDgtanagSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEE 480

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 3892 DEGLIVTIAAVNLVNPNFPAEQPRVQR------PRMESAEILieeNDDPRGIFNF-----HVVRDVGgviiahegpppln 3960
Cdd:TIGR00845  481 DEHFYVRLSNLRVGSEDGILEANHVSAvaqlasPNTATVTIL---DDDHAGIFTFeedvfHVSESIG------------- 544

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039743058 3961 VLQVPVVRMAGTFETVNVYWKATPDSA--GLEDFQPSHGMLQFADGQVIAPILVTIIDDSEFELLETFTISL 4030
Cdd:TIGR00845  545 IMEVKVLRTSGARGTVIVPYRTVEGTArgGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 3911-4147 2.24e-07

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 57.49  E-value: 2.24e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 3911 AEQPRVQRPRMESAEILIEENDDPRGIF----NFHVVRDVGGViiahegppplnvlQVPVVRMAGTF-ETVNVYWKaTPD 3985
Cdd:TIGR00845  376 AADAARKAVSMHEVATDDEENDPVSKIFfepgHYTCLENCGTV-------------ALTVVRRGGDLtNTVYVDYR-TED 441

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 3986 ---SAGlEDFQPSHGMLQFADGQVIAPILVTIIDDSEFELLETFTISLVSVTGG--------------GRLGDDVSVNVV 4048
Cdd:TIGR00845  442 gtaNAG-SDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGsedgileanhvsavAQLASPNTATVT 520

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 4049 IAPNDSPfGIFGFEKKTVMVdgpllsDDPDSYVTLTVVRSPGGKGAVRL-HWAIEEKAK---DDLSPLNGTLYFDETESQ 4124
Cdd:TIGR00845  521 ILDDDHA-GIFTFEEDVFHV------SESIGIMEVKVLRTSGARGTVIVpYRTVEGTARgggKDFEDTCGELEFENDETE 593

                          250       260
                   ....*....|....*....|...
gi 1039743058 4125 KSVILHTLKDGMVGEDRRFIIEL 4147
Cdd:TIGR00845  594 KTIRVKIVDDEEYEKNDTFFIEL 616
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1032-1120 3.08e-07

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 51.10  E-value: 3.08e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  1032 VYFAEPcVLRVQEGE-TANFTVLRNGSVDGACTVQYATVDGKASGEEgDFAPVEKgeTLVFEVGSREQSISVHVKDDGIP 1110
Cdd:smart00237    4 VGFEQP-VYTVSESDgEVEVCVVRTGGARGPVVVPYSTEDGTATAGS-DYEPVPG--ELTFPPGETEKEIRIKIIDDDIY 79

                            90
                    ....*....|
gi 1039743058  1111 ETDEPFYIVL 1120
Cdd:smart00237   80 EKDETFYVRL 89
LamGL smart00560
LamG-like jellyroll fold domain;
1378-1515 6.32e-07

LamG-like jellyroll fold domain;


Pssm-ID: 214722 [Multi-domain]  Cd Length: 133  Bit Score: 51.65  E-value: 6.32e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  1378 FTFSAWVMPNANTNGFLIAKDdshgsiYYGVKIQTNETHVTLSLHYKTFGSNVTYIaksTVMKYLEEGVWLHVLIILD-- 1455
Cdd:smart00560    3 FTLEAWVKLESAGGSQPIITG------AAVAQPTISEKALTFFLRAKSVQGWQTAR---TGATADWIGVWVHLAGVYDgg 73

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039743058  1456 DGIIEFYLDGkamprgikSLKGEAITDGPGI-------LRIGAGMDGGARFTGWMQDVRTYERKLTP 1515
Cdd:smart00560   74 AGKLSLYVNG--------VEVATSETQPSPSsgnlpqgGRILLGGAGGENFSGRLDEVRVYNRALTA 132
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 3961-4030 6.66e-07

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 49.95  E-value: 6.66e-07
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039743058  3961 VLQVPVVRMAGTFETVNVYWKATPDSA-GLEDFQPSHGMLQFADGQVIAPILVTIIDDSEFELLETFTISL 4030
Cdd:smart00237   19 EVEVCVVRTGGARGPVVVPYSTEDGTAtAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDETFYVRL 89
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 273-515 7.06e-07

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 55.95  E-value: 7.06e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  273 ASRSSVEIIVKKNDSP--VNFMQSVYVVPEDDHVLTIPVLRgkdsDGnliGSDETQVSIRYKvmTWDSTAHAQQNVDFID 350
Cdd:TIGR00845  384 VSMHEVATDDEENDPVskIFFEPGHYTCLENCGTVALTVVR----RG---GDLTNTVYVDYR--TEDGTANAGSDYEFTE 454

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  351 lqpdTTLVFPPFVHESHLKFQIIDDLIPEIAESFHI------------MLLKNTLQGDAVLMGPSTVQVTIKPNDKPyGV 418
Cdd:TIGR00845  455 ----GTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVrlsnlrvgsedgILEANHVSAVAQLASPNTATVTILDDDHA-GI 529

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  419 LSFNSILFERpviidedTASSSRFeEIAVVRNGGTHGNVSVSWVLTRNSSDPSPVtaDITPASGTLQFAQGQMLAPISLV 498
Cdd:TIGR00845  530 FTFEEDVFHV-------SESIGIM-EVKVLRTSGARGTVIVPYRTVEGTARGGGK--DFEDTCGELEFENDETEKTIRVK 599

                          250
                   ....*....|....*..
gi 1039743058  499 VFDDDLPEEAEAYLLTI 515
Cdd:TIGR00845  600 IVDDEEYEKNDTFFIEL 616
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2141-2229 3.05e-06

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 48.40  E-value: 3.05e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  2141 GTVQLSATSVHVAENhVGPI-INVTRTGGTFADVSVKFKAVPITAAAGEDYSIASSDVVLLEGETTKAVPIYIINDIYPE 2219
Cdd:smart00237    2 GSVGFEQPVYTVSES-DGEVeVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYE 80

                            90
                    ....*....|
gi 1039743058  2220 LEETFLVQLL 2229
Cdd:smart00237   81 KDETFYVRLS 90
PTX cd00152
Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their ...
 1377-1521 3.18e-06

Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated in innate immunity. CRP binds to ligands containing phosphocholine, SAP binds to amyloid fibrils, DNA, chromatin, fibronectin, C4-binding proteins and glycosaminoglycans. "Long" pentraxins have N-terminal extensions to the common pentraxin domain; one group, the neuronal pentraxins, may be involved in synapse formation and remodeling, and they may also be able to form heteromultimers.


Pssm-ID: 238086  Cd Length: 201  Bit Score: 51.12  E-value: 3.18e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1377 NFTFSAWVMPNANTNGFLIakddshgsIYYGVKIQTNEthvtLSLHYKTFGSNVTYIAKSTVMKYLEE--GVWLHVLIIL 1454
Cdd:cd00152     32 AFTLCLWVYTDLSTREYSL--------FSYATKGQDNE----LLLYKEKDGGYSLYIGGKEVTFKVPEsdGAWHHICVTW 99

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039743058 1455 D--DGIIEFYLDGKAMPRGIKSlKGEAITDGPGIL------RIGAGMDGGARFTGWMQDVRTYERKLTPEEIYEL 1521
Cdd:cd00152    100 EstSGIAELWVNGKLSVRKSLK-KGYTVGPGGSIIlgqeqdSYGGGFDATQSFVGEISDVNMWDSVLSPEEIKNV 173
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 3107-3271 4.96e-06

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 53.26  E-value: 4.96e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 3107 IFLrEPTSLYVQESV-AVLVIVREPAQGLFGTVAVQFVvTEVNSSTESKDLSPSKGFIVLEEGVRSKTLRISAILDTEPE 3185
Cdd:TIGR00845  402 IFF-EPGHYTCLENCgTVALTVVRRGGDLTNTVYVDYR-TEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFE 479

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 3186 MDEHFVCTLFNPTGG--------------ARLGAHVQTLITIFQNQAPlGLFSIsavENSATSidVEESNRSVYLNVSRT 3251
Cdd:TIGR00845  480 EDEHFYVRLSNLRVGsedgileanhvsavAQLASPNTATVTILDDDHA-GIFTF---EEDVFH--VSESIGIMEVKVLRT 553

                          170       180
                   ....*....|....*....|
gi 1039743058 3252 NGLDLTASVQWETVSETAFG 3271
Cdd:TIGR00845  554 SGARGTVIVPYRTVEGTARG 573
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 3609-3650 5.65e-06

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 47.63  E-value: 5.65e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1039743058  3609 QSDFIPSLGELIFEPGDKEAIIAVNVLDDTVPEKEESFRVQL 3650
Cdd:smart00237   48 GSDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDETFYVRL 89
Calx-beta pfam03160
Calx-beta domain;
2141-2228 5.70e-06

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 47.63  E-value: 5.70e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2141 GTVQLSATSVHVAENhVGPI-INVTRTGGTFA-DVSVKFKAVPITAAAGEDYSIASSDVVLLEGETTKAVPIYIINDIYP 2218
Cdd:pfam03160    2 GVIGFEPPTYQVSEN-DGVAeVCVVRMSGTLRrTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVY 80

                           90
                   ....*....|
gi 1039743058 2219 ELEETFLVQL 2228
Cdd:pfam03160   81 EGDENFFVLL 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2256-2346 5.81e-06

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 47.63  E-value: 5.81e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  2256 GLFGFQNTKFIVEEpefNSVRVNVPIIRNSGTLGNVTVQWVAIINGQFATGDLRVVSGNVTFAPGETIQTLLLEVLADDV 2335
Cdd:smart00237    2 GSVGFEQPVYTVSE---SDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDI 78

                            90
                    ....*....|.
gi 1039743058  2336 PEIEEVVQVQL 2346
Cdd:smart00237   79 YEKDETFYVRL 89
Calx-beta pfam03160
Calx-beta domain;
3961-4030 6.11e-06

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 47.24  E-value: 6.11e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039743058 3961 VLQVPVVRMAGTFE-TVNVYWKATPDSA-GLEDFQPSHGMLQFADGQVIAPILVTIIDDSEFELLETFTISL 4030
Cdd:pfam03160   19 VAEVCVVRMSGTLRrTVVVPYRTEDGTAtAGDDYEPVEGELVFGPGETEKCINVTIIDDDVYEGDENFFVLL 90
Calx-beta pfam03160
Calx-beta domain;
2862-2948 1.47e-05

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 46.47  E-value: 1.47e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2862 EANVTIQLFVNREFGSL-GAINVTYATVPGIvslknntegnlAEPESDFIPVVGSLVLEEGETTAAISITVLEDDIPELK 2940
Cdd:pfam03160   15 ENDGVAEVCVVRMSGTLrRTVVVPYRTEDGT-----------ATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVYEGD 83


                   ....*...
gi 1039743058 2941 EYFLVNLT 2948
Cdd:pfam03160   84 ENFFVLLS 91
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 3419-3460 6.86e-05

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 42.84  E-value: 6.86e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1039743058 3419 FAWHQTLPVRGVLGMALFSRGGSVFLAISQANIRqtSLLFTW 3460
Cdd:pfam03736    2 FVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGD--SVIYRW 41
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 289-389 1.46e-04

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 43.40  E-value: 1.46e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058   289 VNFMQSVYVVPEDDHVLTIPVLRGKDSDGNligsdetqVSIRYKvmTWDSTAHAQQnvDFIDLqpDTTLVFPPFVHESHL 368
Cdd:smart00237    4 VGFEQPVYTVSESDGEVEVCVVRTGGARGP--------VVVPYS--TEDGTATAGS--DYEPV--PGELTFPPGETEKEI 69

                            90       100
                    ....*....|....*....|.
gi 1039743058   369 KFQIIDDLIPEIAESFHIMLL 389
Cdd:smart00237   70 RIKIIDDDIYEKDETFYVRLS 90
Calx-beta pfam03160
Calx-beta domain;
3610-3650 1.52e-04

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 43.39  E-value: 1.52e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1039743058 3610 SDFIPSLGELIFEPGDKEAIIAVNVLDDTVPEKEESFRVQL 3650
Cdd:pfam03160   50 DDYEPVEGELVFGPGETEKCINVTIIDDDVYEGDENFFVLL 90
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 165-388 2.07e-04

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 47.86  E-value: 2.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  165 SNDNAFGIisFSTPSSISVIEprsRNASVPLTLIREKGTYGM-VTVTFDVSGGPNPPEEDLNPVRGNITFPPGRATVIYN 243
Cdd:TIGR00845  395 ENDPVSKI--FFEPGHYTCLE---NCGTVALTVVRRGGDLTNtVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFR 469

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  244 VTVLDDEVPENDELFLIQLRSVEGGAEINASRSSVEIIVKKNDSPV---------------NFMQSVYVVPEDDHVLTIP 308
Cdd:TIGR00845  470 IGIIDDDIFEEDEHFYVRLSNLRVGSEDGILEANHVSAVAQLASPNtatvtildddhagifTFEEDVFHVSESIGIMEVK 549

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  309 VLRGKDSDGNLIgsdetqvsIRYKvmTWDSTAHAqQNVDFIDLQPDttLVFPPFVHESHLKFQIIDDLIPEIAESFHIML 388
Cdd:TIGR00845  550 VLRTSGARGTVI--------VPYR--TVEGTARG-GGKDFEDTCGE--LEFENDETEKTIRVKIVDDEEYEKNDTFFIEL 616
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 2868-2948 2.24e-04

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 43.01  E-value: 2.24e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  2868 QLFVNREFGSLGAINVTYATVPGivslkNNTEGnlaepeSDFIPVVGSLVLEEGETTAAISITVLEDDIPELKEYFLVNL 2947
Cdd:smart00237   21 EVCVVRTGGARGPVVVPYSTEDG-----TATAG------SDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDETFYVRL 89


                    .
gi 1039743058  2948 T 2948
Cdd:smart00237   90 S 90
PTX smart00159
Pentraxin / C-reactive protein / pentaxin family; This family form a doscoid pentameric ...
 1377-1521 2.45e-04

Pentraxin / C-reactive protein / pentaxin family; This family form a doscoid pentameric structure. Human serum amyloid P demonstrates calcium-mediated ligand-binding.


Pssm-ID: 128463  Cd Length: 206  Bit Score: 45.72  E-value: 2.45e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  1377 NFTFSAWVMPNANTNGfliakddshGSIY-YGVKIQTNEthvtLSLHYKTFGSNVTYI--AKSTVMKYLEEGVWLHVLII 1453
Cdd:smart00159   32 AFTVCLWFYSDLSPRG---------YSLFsYATKGQDNE----LLLYKEKQGEYSLYIggKKVQFPVPESDGKWHHICTT 98

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039743058  1454 LD--DGIIEFYLDGKAMPRgiKSL-KGEAITDGPGIL------RIGAGMDGGARFTGWMQDVRTYERKLTPEEIYEL 1521
Cdd:smart00159   99 WEssSGIAELWVDGKPGVR--KGLaKGYTVKPGGSIIlgqeqdSYGGGFDATQSFVGEIGDLNMWDSVLSPEEIKSV 173
Calx-beta pfam03160
Calx-beta domain;
4423-4511 3.58e-04

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 42.24  E-value: 3.58e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 4423 GIIEFDPkyTDISVEEDAGVITLPVLRLHGTY-GHVSADFSSRGFSAVPGG-YVLHGSSVTFQHGQNLSFINVSIIDDNG 4500
Cdd:pfam03160    2 GVIGFEP--PTYQVSENDGVAEVCVVRMSGTLrRTVVVPYRTEDGTATAGDdYEPVEGELVFGPGETEKCINVTIIDDDV 79

                           90
                   ....*....|.
gi 1039743058 4501 SEFEKQFEILL 4511
Cdd:pfam03160   80 YEGDENFFVLL 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 4423-4511 3.80e-04

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 42.24  E-value: 3.80e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  4423 GIIEFD-PKYTdisVEEDAGVITLPVLRLHGTYGHVSADFSSRGFSAVPGG-YVLHGSSVTFQHGQNLSFINVSIIDDNG 4500
Cdd:smart00237    2 GSVGFEqPVYT---VSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSdYEPVPGELTFPPGETEKEIRIKIIDDDI 78

                            90
                    ....*....|.
gi 1039743058  4501 SEFEKQFEILL 4511
Cdd:smart00237   79 YEKDETFYVRL 89
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 4418-4657 4.50e-04

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 46.71  E-value: 4.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 4418 NDNAEGIIeFDP-KYTdisVEEDAGVITLPVLRLHGTYG-HVSADFSSRGFSAVPGG-YVLHGSSVTFQHGQNLSFINVS 4494
Cdd:TIGR00845  396 NDPVSKIF-FEPgHYT---CLENCGTVALTVVRRGGDLTnTVYVDYRTEDGTANAGSdYEFTEGTLVFKPGETQKEFRIG 471

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 4495 IIDDNGSEFEKQFEILL--------------IGATGGAILGRHLVSKITIAKSDSPfGIIRFlNQSKISLPNPSSTMALH 4560
Cdd:TIGR00845  472 IIDDDIFEEDEHFYVRLsnlrvgsedgileaNHVSAVAQLASPNTATVTILDDDHA-GIFTF-EEDVFHVSESIGIMEVK 549

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 4561 LVleRTGGLLGEIQVSWEVVGPDAEEplppHNGDFADpVSGTVSFGDGEgGVRSIILRVCPHEETEAEETFIVQLKPLRE 4640
Cdd:TIGR00845  550 VL--RTSGARGTVIVPYRTVEGTARG----GGKDFED-TCGELEFENDE-TEKTIRVKIVDDEEYEKNDTFFIELGEPRW 621

                          250       260
                   ....*....|....*....|
gi 1039743058 4641 AKLD---PRAKAVTLTGASK 4657
Cdd:TIGR00845  622 AKRGikaALLLNETITDDDQ 641
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 707-1001 4.61e-04

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 46.71  E-value: 4.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  707 RDGTDGQATVYWSLRPSGFNSKAVTldDAGPFNGSVVFLSGQNETSINITVKGDDIPELNET--VTLSLDRVSVDSDVLK 784
Cdd:TIGR00845  424 RRGGDLTNTVYVDYRTEDGTANAGS--DYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHfyVRLSNLRVGSEDGILE 501

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  785 SGYTSR----------DLIILEnDDPGGIFEFSYDSRgpYVIKEGDAVELRITRSRGSLVKQFLRFHVE---PRESNE-F 850
Cdd:TIGR00845  502 ANHVSAvaqlaspntaTVTILD-DDHAGIFTFEEDVF--HVSESIGIMEVKVLRTSGARGTVIVPYRTVegtARGGGKdF 578

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  851 YGNMGVLEFTPGEREVVITLLTRLDGTPELDEHFWVILSSHGERESKLGCATLVNITILKNDYPHGIIEFVSDGLSASIK 930
Cdd:TIGR00845  579 EDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKAALLLNETITDDDQKLTSKEEEERRIAEMGK 658

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039743058  931 ESKGEDIyhAVYGVIRTRGNFGAVnVSWMVSpdfTQDVFPVQGTVCFGDQeFFKNITVYSLVDEIPEEMEE 1001
Cdd:TIGR00845  659 PRLGEHT--KLEVIIEESYEFKST-VDKLIK---KTNLALVVGTHSWREQ-FIEAITVSAGDDDDDDEDGE 722
Calx-beta pfam03160
Calx-beta domain;
171-262 4.90e-04

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 41.85  E-value: 4.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  171 GIISFStPSSISVIEprsRNASVPLTLIREKGTY-GMVTVTFDVSGGPNPPEEDLNPVRGNITFPPGRATVIYNVTVLDD 249
Cdd:pfam03160    2 GVIGFE-PPTYQVSE---NDGVAEVCVVRMSGTLrRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDD 77

                           90
                   ....*....|...
gi 1039743058  250 EVPENDELFLIQL 262
Cdd:pfam03160   78 DVYEGDENFFVLL 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 1609-1688 9.53e-04

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 41.09  E-value: 9.53e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  1609 TEEGSTVSCVVERTRGALGYVHV-FYTISQIESEGinylvDDFANASGTITFLPWQRSEVLNLYVLDEDMPELNEYFRVT 1687
Cdd:smart00237   14 SESDGEVEVCVVRTGGARGPVVVpYSTEDGTATAG-----SDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDETFYVR 88


                    .
gi 1039743058  1688 L 1688
Cdd:smart00237   89 L 89
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 171-262 1.58e-03

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 40.70  E-value: 1.58e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058   171 GIISFsTPSSISVIEprsrNA-SVPLTLIREKGTYGMVTVTFDVSGGPNPPEEDLNPVRGNITFPPGRATVIYNVTVLDD 249
Cdd:smart00237    2 GSVGF-EQPVYTVSE----SDgEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDD 76

                            90
                    ....*....|...
gi 1039743058   250 EVPENDELFLIQL 262
Cdd:smart00237   77 DIYEKDETFYVRL 89
Calx-beta pfam03160
Calx-beta domain;
1596-1688 1.60e-03

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 40.70  E-value: 1.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 1596 GLFGFTGACIPEMTEEGSTVSCVVeRTRGAL-GYVHV-FYTISQIESEGinylvDDFANASGTITFLPWQRSEVLNLYVL 1673
Cdd:pfam03160    2 GVIGFEPPTYQVSENDGVAEVCVV-RMSGTLrRTVVVpYRTEDGTATAG-----DDYEPVEGELVFGPGETEKCINVTII 75

                           90
                   ....*....|....*
gi 1039743058 1674 DEDMPELNEYFRVTL 1688
Cdd:pfam03160   76 DDDVYEGDENFFVLL 90
Calx-beta pfam03160
Calx-beta domain;
2256-2347 1.63e-03

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 40.70  E-value: 1.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058 2256 GLFGFQNTKFIVEEpefNSVRVNVPIIRNSGTL-GNVTVQWVAIiNGQfATG--DLRVVSGNVTFAPGETIQTLLLEVLA 2332
Cdd:pfam03160    2 GVIGFEPPTYQVSE---NDGVAEVCVVRMSGTLrRTVVVPYRTE-DGT-ATAgdDYEPVEGELVFGPGETEKCINVTIID 76

                           90
                   ....*....|....*
gi 1039743058 2333 DDVPEIEEVVQVQLA 2347
Cdd:pfam03160   77 DDVYEGDENFFVLLS 91
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 4057-4148 3.82e-03

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 39.55  E-value: 3.82e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058  4057 GIFGFEKKTVMV---DGPllsddpdsyVTLTVVRSPGGKGAVRLHWAIEE---KAKDDLSPLNGTLYFDETESQKSVILH 4130
Cdd:smart00237    2 GSVGFEQPVYTVsesDGE---------VEVCVVRTGGARGPVVVPYSTEDgtaTAGSDYEPVPGELTFPPGETEKEIRIK 72

                            90
                    ....*....|....*...
gi 1039743058  4131 TLKDGMVGEDRRFIIELT 4148
Cdd:smart00237   73 IIDDDIYEKDETFYVRLS 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 63-143 9.20e-03

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 38.39  E-value: 9.20e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039743058    63 GQTEFFVNETSTTViRLVIERIGEpANVTAIVSLSGED-TGdffdTYAAAFIPARG--------TNRTVYIAVCDDDLPE 133
Cdd:smart00237    7 EQPVYTVSESDGEV-EVCVVRTGG-ARGPVVVPYSTEDgTA----TAGSDYEPVPGeltfppgeTEKEIRIKIIDDDIYE 80

                            90
                    ....*....|
gi 1039743058   134 PDETFTFHLT 143
Cdd:smart00237   81 KDETFYVRLS 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 444-516 9.57e-03

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 38.39  E-value: 9.57e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039743058   444 EIAVVRNGGTHGNVSVSWVLtrnssdpSPVTA----DITPASGTLQFAQGQMLAPISLVVFDDDLPEEAEAYLLTIL 516
Cdd:smart00237   21 EVCVVRTGGARGPVVVPYST-------EDGTAtagsDYEPVPGELTFPPGETEKEIRIKIIDDDIYEKDETFYVRLS 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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