potassium voltage-gated channel subfamily KQT member 2 isoform X5 [Mus musculus]
Protein Classification
potassium voltage-gated channel subfamily KQT member 2( domain architecture ID 11999099)
potassium voltage-gated channel subfamily KQT member 2 (KCNQ2) associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| KCNQ_channel | pfam03520 | KCNQ voltage-gated potassium channel; This family matches to the C-terminal tail of KCNQ type ... |
454-707 | 2.72e-109 | |||||
KCNQ voltage-gated potassium channel; This family matches to the C-terminal tail of KCNQ type potassium channels. : Pssm-ID: 460954 Cd Length: 190 Bit Score: 334.81 E-value: 2.72e-109
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| KCNQC3-Ank-G_bd | pfam11956 | Ankyrin-G binding motif of KCNQ2-3; Interactions with ankyrin-G are crucial to the ... |
821-921 | 2.72e-56 | |||||
Ankyrin-G binding motif of KCNQ2-3; Interactions with ankyrin-G are crucial to the localization of voltage-gated sodium channels (VGSCs) at the axon initial segment and for neurons to initiate action potentials. This conserved 9-amino acid motif ((V/A)P(I/L)AXXE(S/D)D) is required for ankyrin-G binding and functions to localize sodium channels to a variety of 'excitable' membrane domains both inside and outside of the nervous system. This motif has also been identified in the potassium channel 6TM proteins KCNQ2 and KCNQ3, that correspond to the M channels that exert a crucial influence over neuronal excitability. KCNQ2/KCNQ3 channels are preferentially localized to the surface of axons both at the axonal initial segment and more distally, and this axonal initial segment targeting of surface KCNQ channels is mediated by these ankyrin-G binding motifs of KCNQ2 and KCNQ3. KCNQ3 is a major determinant of M channel localization to the AIS, rather than KCNQ2. Phylogenetic analysis reveals that anchor motifs evolved sequentially in chordates (NaV channel) and jawed vertebrates (KCNQ2/3). : Pssm-ID: 463411 Cd Length: 101 Bit Score: 188.83 E-value: 2.72e-56
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| Ion_trans | pfam00520 | Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ... |
92-324 | 8.72e-41 | |||||
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. : Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 150.11 E-value: 8.72e-41
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| KCNQ2_u3 | pfam16642 | Unstructured region on Potassium channel subunit alpha KvLQT2; KCNQ2_u3 is a region of ... |
721-809 | 7.47e-40 | |||||
Unstructured region on Potassium channel subunit alpha KvLQT2; KCNQ2_u3 is a region of natively unstructured sequence on potassium voltage-gated channel subfamily KQT member 2 proteins from higher eukaryotes. It lies between families KCNQ_channel, pfam03520, and KCNQC3-Ank_bd, pfam11956. The function is not known. : Pssm-ID: 465213 Cd Length: 98 Bit Score: 142.32 E-value: 7.47e-40
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| Name | Accession | Description | Interval | E-value | |||||
| KCNQ_channel | pfam03520 | KCNQ voltage-gated potassium channel; This family matches to the C-terminal tail of KCNQ type ... |
454-707 | 2.72e-109 | |||||
KCNQ voltage-gated potassium channel; This family matches to the C-terminal tail of KCNQ type potassium channels. Pssm-ID: 460954 Cd Length: 190 Bit Score: 334.81 E-value: 2.72e-109
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| KCNQC3-Ank-G_bd | pfam11956 | Ankyrin-G binding motif of KCNQ2-3; Interactions with ankyrin-G are crucial to the ... |
821-921 | 2.72e-56 | |||||
Ankyrin-G binding motif of KCNQ2-3; Interactions with ankyrin-G are crucial to the localization of voltage-gated sodium channels (VGSCs) at the axon initial segment and for neurons to initiate action potentials. This conserved 9-amino acid motif ((V/A)P(I/L)AXXE(S/D)D) is required for ankyrin-G binding and functions to localize sodium channels to a variety of 'excitable' membrane domains both inside and outside of the nervous system. This motif has also been identified in the potassium channel 6TM proteins KCNQ2 and KCNQ3, that correspond to the M channels that exert a crucial influence over neuronal excitability. KCNQ2/KCNQ3 channels are preferentially localized to the surface of axons both at the axonal initial segment and more distally, and this axonal initial segment targeting of surface KCNQ channels is mediated by these ankyrin-G binding motifs of KCNQ2 and KCNQ3. KCNQ3 is a major determinant of M channel localization to the AIS, rather than KCNQ2. Phylogenetic analysis reveals that anchor motifs evolved sequentially in chordates (NaV channel) and jawed vertebrates (KCNQ2/3). Pssm-ID: 463411 Cd Length: 101 Bit Score: 188.83 E-value: 2.72e-56
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| Ion_trans | pfam00520 | Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ... |
92-324 | 8.72e-41 | |||||
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 150.11 E-value: 8.72e-41
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| KCNQ2_u3 | pfam16642 | Unstructured region on Potassium channel subunit alpha KvLQT2; KCNQ2_u3 is a region of ... |
721-809 | 7.47e-40 | |||||
Unstructured region on Potassium channel subunit alpha KvLQT2; KCNQ2_u3 is a region of natively unstructured sequence on potassium voltage-gated channel subfamily KQT member 2 proteins from higher eukaryotes. It lies between families KCNQ_channel, pfam03520, and KCNQC3-Ank_bd, pfam11956. The function is not known. Pssm-ID: 465213 Cd Length: 98 Bit Score: 142.32 E-value: 7.47e-40
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| Name | Accession | Description | Interval | E-value | |||||
| KCNQ_channel | pfam03520 | KCNQ voltage-gated potassium channel; This family matches to the C-terminal tail of KCNQ type ... |
454-707 | 2.72e-109 | |||||
KCNQ voltage-gated potassium channel; This family matches to the C-terminal tail of KCNQ type potassium channels. Pssm-ID: 460954 Cd Length: 190 Bit Score: 334.81 E-value: 2.72e-109
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| KCNQC3-Ank-G_bd | pfam11956 | Ankyrin-G binding motif of KCNQ2-3; Interactions with ankyrin-G are crucial to the ... |
821-921 | 2.72e-56 | |||||
Ankyrin-G binding motif of KCNQ2-3; Interactions with ankyrin-G are crucial to the localization of voltage-gated sodium channels (VGSCs) at the axon initial segment and for neurons to initiate action potentials. This conserved 9-amino acid motif ((V/A)P(I/L)AXXE(S/D)D) is required for ankyrin-G binding and functions to localize sodium channels to a variety of 'excitable' membrane domains both inside and outside of the nervous system. This motif has also been identified in the potassium channel 6TM proteins KCNQ2 and KCNQ3, that correspond to the M channels that exert a crucial influence over neuronal excitability. KCNQ2/KCNQ3 channels are preferentially localized to the surface of axons both at the axonal initial segment and more distally, and this axonal initial segment targeting of surface KCNQ channels is mediated by these ankyrin-G binding motifs of KCNQ2 and KCNQ3. KCNQ3 is a major determinant of M channel localization to the AIS, rather than KCNQ2. Phylogenetic analysis reveals that anchor motifs evolved sequentially in chordates (NaV channel) and jawed vertebrates (KCNQ2/3). Pssm-ID: 463411 Cd Length: 101 Bit Score: 188.83 E-value: 2.72e-56
|
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| Ion_trans | pfam00520 | Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ... |
92-324 | 8.72e-41 | |||||
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane. Pssm-ID: 459842 [Multi-domain] Cd Length: 238 Bit Score: 150.11 E-value: 8.72e-41
|
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| KCNQ2_u3 | pfam16642 | Unstructured region on Potassium channel subunit alpha KvLQT2; KCNQ2_u3 is a region of ... |
721-809 | 7.47e-40 | |||||
Unstructured region on Potassium channel subunit alpha KvLQT2; KCNQ2_u3 is a region of natively unstructured sequence on potassium voltage-gated channel subfamily KQT member 2 proteins from higher eukaryotes. It lies between families KCNQ_channel, pfam03520, and KCNQC3-Ank_bd, pfam11956. The function is not known. Pssm-ID: 465213 Cd Length: 98 Bit Score: 142.32 E-value: 7.47e-40
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| Ion_trans_2 | pfam07885 | Ion channel; This family includes the two membrane helix type ion channels found in bacteria. |
240-314 | 1.47e-14 | |||||
Ion channel; This family includes the two membrane helix type ion channels found in bacteria. Pssm-ID: 462301 [Multi-domain] Cd Length: 78 Bit Score: 69.60 E-value: 1.47e-14
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