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Conserved domains on  [gi|1039746333|ref|XP_017171544|]
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fibronectin type-III domain-containing protein 3A isoform X2 [Mus musculus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10045852)

fibronectin type III (FN3) domain-containing protein with an immunoglobulin-like (Ig-like) fold similar to mammalian interleukin-9 and interleukin-21 receptors, and to immunoglobulin I-set domains (antibody intermediate domain-like) such as myomesin, contactin, neural cell adhesion molecule 1, roundabout homologs, and cell adhesion molecules, among others

CATH:  2.60.40.10
Gene Ontology:  GO:0005515
PubMed:  9541533|7833045|8981327|7932691

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
251-597 4.62e-16

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 83.13  E-value: 4.62e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  251 ASDIQARTVLLTWSPPSSFINGEVNETAVPELFNYEVLVSSTGKegkyrSVYIGEETSVTLNDLKPATDYHAKVQAESNS 330
Cdd:COG3401    141 YALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTS-----LTVTSTTLVDGGGDIEPGTTYYYRVAATDTG 215

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  331 IKGIPSEAESFTTLSCEPDPPNAPRIANRTKNSLTLQWKAPSDNGskIQSFILEWDEgKGNGEFCQCYMGSQKQFKITKL 410
Cdd:COG3401    216 GESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSN-SGDGPFTKVATVTTTSYTDTGL 292

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  411 SPAMGCKFRLSAKNDYGV-SDFSEEVLYYTSGCAPSVPASPVLTKAGVTWLSLQWTKPSG-----------TPSDEGISY 478
Cdd:COG3401    293 TNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDadvtgynvyrsTSGGGTYTK 372

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  479 ILEMEEETSgygfkpkydgedlaYTVKNLRRSTKYKFKVIAYNSEG-KSNPSEVVEF---STCPDKPGVPVKPSVKGKIH 554
Cdd:COG3401    373 IAETVTTTS--------------YTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSAttaSAASGESLTASVDAVPLTDV 438

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 1039746333  555 SHGFKITWDPPKDNGGAPINKYVVEMAEGSNGNKWDMIYSGTT 597
Cdd:COG3401    439 AGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATT 481
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
795-1073 4.28e-14

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 76.96  E-value: 4.28e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  795 GLSPATTYYCRVQAMSVVGAGPFS---EVVACVTPPSVPAIVTcLQEISDDDIEyphyspstclaISWKEPYDHGseILA 871
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSnevSVTTPTTPPSAPTGLT-ATADTPGSVT-----------LSWDPVTESD--ATG 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  872 YSI-----DLGDKQPLTVGKMTSYIIDSLQPDTTYRIRIQALNSLG-AGPFSHTIKLKTKPLPPDPPR-LECVAFNHQNL 944
Cdd:COG3401    264 YRVyrsnsGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSgLTATAVGSSSI 343

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  945 KLKWGEGTpktlSTDAVQYHL-QMEDRNGRFVSLYRGPC-HTYKVQRLSESTSYKFCIQACNEAGEGPLSQEYVFTTPKS 1022
Cdd:COG3401    344 TLSWTASS----DADVTGYNVyRSTSGGGTYTKIAETVTtTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTAS 419

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039746333 1023 LPAA--LKAPKIEKINDHICEITWEYLQPmkGDPVIYNLQVMVGKDSEFKQIY 1073
Cdd:COG3401    420 AASGesLTASVDAVPLTDVAGATAAASAA--SNPGVSAAVLADGGDTGNAVPF 470
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 655-731 1.84e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.44  E-value: 1.84e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039746333  655 EIQLRWGPPQvDGGSPISCYAVEMTPADKDEPRDV--YQGSEVECTVGSLLPGKTYSFRLRAANRIGFGPFSEKYDITT 731
Cdd:cd00063     16 SVTLSWTPPE-DDGGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 733-825 7.87e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.51  E-value: 7.87e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  733 PGPPdqcRPPQVTCRSATCAQVNWEIPLSNGTDVTEYRLEWGGV-EGSMQMC--YCGPGLSCELKGLSPATTYYCRVQAM 809
Cdd:cd00063      1 PSPP---TNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKgSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*.
gi 1039746333  810 SVVGAGPFSEVVACVT 825
Cdd:cd00063     78 NGGGESPPSESVTVTT 93
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
251-597 4.62e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 83.13  E-value: 4.62e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  251 ASDIQARTVLLTWSPPSSFINGEVNETAVPELFNYEVLVSSTGKegkyrSVYIGEETSVTLNDLKPATDYHAKVQAESNS 330
Cdd:COG3401    141 YALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTS-----LTVTSTTLVDGGGDIEPGTTYYYRVAATDTG 215

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  331 IKGIPSEAESFTTLSCEPDPPNAPRIANRTKNSLTLQWKAPSDNGskIQSFILEWDEgKGNGEFCQCYMGSQKQFKITKL 410
Cdd:COG3401    216 GESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSN-SGDGPFTKVATVTTTSYTDTGL 292

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  411 SPAMGCKFRLSAKNDYGV-SDFSEEVLYYTSGCAPSVPASPVLTKAGVTWLSLQWTKPSG-----------TPSDEGISY 478
Cdd:COG3401    293 TNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDadvtgynvyrsTSGGGTYTK 372

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  479 ILEMEEETSgygfkpkydgedlaYTVKNLRRSTKYKFKVIAYNSEG-KSNPSEVVEF---STCPDKPGVPVKPSVKGKIH 554
Cdd:COG3401    373 IAETVTTTS--------------YTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSAttaSAASGESLTASVDAVPLTDV 438

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 1039746333  555 SHGFKITWDPPKDNGGAPINKYVVEMAEGSNGNKWDMIYSGTT 597
Cdd:COG3401    439 AGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATT 481
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 348-439 8.77e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.99  E-value: 8.77e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  348 PDPPNAPRIANRTKNSLTLQWKAPSDNGSKIQSFILEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSAKNDY 426
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYrEKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 1039746333  427 GVSDFSEEVLYYT 439
Cdd:cd00063     81 GESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
795-1073 4.28e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 76.96  E-value: 4.28e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  795 GLSPATTYYCRVQAMSVVGAGPFS---EVVACVTPPSVPAIVTcLQEISDDDIEyphyspstclaISWKEPYDHGseILA 871
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSnevSVTTPTTPPSAPTGLT-ATADTPGSVT-----------LSWDPVTESD--ATG 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  872 YSI-----DLGDKQPLTVGKMTSYIIDSLQPDTTYRIRIQALNSLG-AGPFSHTIKLKTKPLPPDPPR-LECVAFNHQNL 944
Cdd:COG3401    264 YRVyrsnsGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSgLTATAVGSSSI 343

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  945 KLKWGEGTpktlSTDAVQYHL-QMEDRNGRFVSLYRGPC-HTYKVQRLSESTSYKFCIQACNEAGEGPLSQEYVFTTPKS 1022
Cdd:COG3401    344 TLSWTASS----DADVTGYNVyRSTSGGGTYTKIAETVTtTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTAS 419

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039746333 1023 LPAA--LKAPKIEKINDHICEITWEYLQPmkGDPVIYNLQVMVGKDSEFKQIY 1073
Cdd:COG3401    420 AASGesLTASVDAVPLTDVAGATAAASAA--SNPGVSAAVLADGGDTGNAVPF 470
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 852-924 1.66e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.44  E-value: 1.66e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  852 STCLAISWKEPYDHGSEILAYSI---DLGDKQPLTV----GKMTSYIIDSLQPDTTYRIRIQALNSLGAGPFSHTIKLKT 924
Cdd:cd00063     14 STSVTLSWTPPEDDGGPITGYVVeyrEKGSGDWKEVevtpGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 655-731 1.84e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.44  E-value: 1.84e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039746333  655 EIQLRWGPPQvDGGSPISCYAVEMTPADKDEPRDV--YQGSEVECTVGSLLPGKTYSFRLRAANRIGFGPFSEKYDITT 731
Cdd:cd00063     16 SVTLSWTPPE-DDGGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 733-825 7.87e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.51  E-value: 7.87e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  733 PGPPdqcRPPQVTCRSATCAQVNWEIPLSNGTDVTEYRLEWGGV-EGSMQMC--YCGPGLSCELKGLSPATTYYCRVQAM 809
Cdd:cd00063      1 PSPP---TNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKgSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*.
gi 1039746333  810 SVVGAGPFSEVVACVT 825
Cdd:cd00063     78 NGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 348-429 1.85e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.31  E-value: 1.85e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333   348 PDPPNAPRIANRTKNSLTLQWKAPSDNG--SKIQSFILEWDEGKGNGEFCQCyMGSQKQFKITKLSPAMGCKFRLSAKND 425
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 1039746333   426 YGVS 429
Cdd:smart00060   80 AGEG 83
fn3 pfam00041
Fibronectin type III domain;
249-336 2.65e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 2.65e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  249 PVASDIQARTVLLTWSPPSSfINGEVNetavpelfNYEVLVSSTGKEGKYRSVYI-GEETSVTLNDLKPATDYHAKVQAE 327
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPD-GNGPIT--------GYEVEYRPKNSGEPWNEITVpGTTTSVTLTGLKPGTEYEVRVQAV 76


                   ....*....
gi 1039746333  328 SNSIKGIPS 336
Cdd:pfam00041   77 NGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
852-917 3.25e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.73  E-value: 3.25e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039746333  852 STCLAISWKEPYDHGSEILAYSI------DLGDKQPLTVGKMT-SYIIDSLQPDTTYRIRIQALNSLGAGPFS 917
Cdd:pfam00041   13 STSLTVSWTPPPDGNGPITGYEVeyrpknSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 733-815 5.11e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.16  E-value: 5.11e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333   733 PGPPdqcRPPQVTCRSATCAQVNWEIPLSNGTD--VTEYRLEWGGVEGSMQMCYCGPG-LSCELKGLSPATTYYCRVQAM 809
Cdd:smart00060    1 PSPP---SNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEVNVTPSsTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 1039746333   810 SVVGAG 815
Cdd:smart00060   78 NGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
740-818 1.08e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 1.08e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  740 RPPQVTCRSATCAQVNWEIPLSNGTDVTEYRLEW---GGVEGSMQMCYCGPGLSCELKGLSPATTYYCRVQAMSVVGAGP 816
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYrpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGP 83


                   ..
gi 1039746333  817 FS 818
Cdd:pfam00041   84 PS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 639-721 1.43e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.00  E-value: 1.43e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333   639 PGPclPPRLQGRPKAKE-IQLRWGPPQVDGG-SPISCYAVEMTPADKDEPRDVYQGSEVECTVGSLLPGKTYSFRLRAAN 716
Cdd:smart00060    1 PSP--PSNLRVTDVTSTsVTLSWEPPPDDGItGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 1039746333   717 RIGFG 721
Cdd:smart00060   79 GAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 852-914 1.91e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.62  E-value: 1.91e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333   852 STCLAISWKEPYDHG--SEILAYSIDLGDKQPL-----TVGKMTSYIIDSLQPDTTYRIRIQALNSLGAG 914
Cdd:smart00060   14 STSVTLSWEPPPDDGitGYIVGYRVEYREEGSEwkevnVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
655-724 3.66e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 51.65  E-value: 3.66e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039746333  655 EIQLRWGPPQvDGGSPISCYAVEMTPADKDEPRDVYQ--GSEVECTVGSLLPGKTYSFRLRAANRIGFGPFS 724
Cdd:pfam00041   15 SLTVSWTPPP-DGNGPITGYEVEYRPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
 
Name Accession Description Interval E-value
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
251-597 4.62e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 83.13  E-value: 4.62e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  251 ASDIQARTVLLTWSPPSSFINGEVNETAVPELFNYEVLVSSTGKegkyrSVYIGEETSVTLNDLKPATDYHAKVQAESNS 330
Cdd:COG3401    141 YALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTS-----LTVTSTTLVDGGGDIEPGTTYYYRVAATDTG 215

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  331 IKGIPSEAESFTTLSCEPDPPNAPRIANRTKNSLTLQWKAPSDNGskIQSFILEWDEgKGNGEFCQCYMGSQKQFKITKL 410
Cdd:COG3401    216 GESAPSNEVSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESD--ATGYRVYRSN-SGDGPFTKVATVTTTSYTDTGL 292

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  411 SPAMGCKFRLSAKNDYGV-SDFSEEVLYYTSGCAPSVPASPVLTKAGVTWLSLQWTKPSG-----------TPSDEGISY 478
Cdd:COG3401    293 TNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDadvtgynvyrsTSGGGTYTK 372

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  479 ILEMEEETSgygfkpkydgedlaYTVKNLRRSTKYKFKVIAYNSEG-KSNPSEVVEF---STCPDKPGVPVKPSVKGKIH 554
Cdd:COG3401    373 IAETVTTTS--------------YTDTGLTPGTTYYYKVTAVDAAGnESAPSEEVSAttaSAASGESLTASVDAVPLTDV 438

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|...
gi 1039746333  555 SHGFKITWDPPKDNGGAPINKYVVEMAEGSNGNKWDMIYSGTT 597
Cdd:COG3401    439 AGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATT 481
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
421-910 9.05e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 82.36  E-value: 9.05e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  421 SAKNDYGVSDFSEEVLYYTSGCAPSVPASPVLTKAGVTWLSLQWTKPSGTPSDEGISYILEMEEETSGYGFKPKYDGEDL 500
Cdd:COG3401     16 SAAANTAVNALSKAGGSGKTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLT 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  501 AYTVKNLRRSTKYKFKVIAYNsegksnPSEVVEFSTCPDKPGVPVKPSVKGKIHSHGFKITWDPPKDNGGAPINKYVVEM 580
Cdd:COG3401     96 TLTGSGSVGGATNTGLTSSDE------VPSPAVGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVV 169

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  581 AEGSNGNKWDMIYSGTTREH-----LCDRLTPGCYYRLRVYCISDGGQSAVSESLLVQTPAVPPGPclPPRLQGRPK-AK 654
Cdd:COG3401    170 VSPDTSATAAVATTSLTVTSttlvdGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPPSA--PTGLTATADtPG 247

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  655 EIQLRWGPPQVDGgspISCYAVEMTPADKDEPRDVYQGSEVECTVGSLLPGKTYSFRLRAANRIGF-GPFSEKYDITTAP 733
Cdd:COG3401    248 SVTLSWDPVTESD---ATGYRVYRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGNeSAPSNVVSVTTDL 324

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  734 GPPDqcrPPQ-VTCRSATCAQV--NWEipLSNGTDVTEYRLE-WGGVEGSMQ-MCYCGPGLSCELKGLSPATTYYCRVQA 808
Cdd:COG3401    325 TPPA---APSgLTATAVGSSSItlSWT--ASSDADVTGYNVYrSTSGGGTYTkIAETVTTTSYTDTGLTPGTTYYYKVTA 399

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  809 MSVvgAGPFSEVVACVTPPSVPAIVTCLQEISDDDIEYPHYSPSTcLAISWKEPYDHGSEILAYSIDLGDKQPLTVGKMT 888
Cdd:COG3401    400 VDA--AGNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGAT-AAASAASNPGVSAAVLADGGDTGNAVPFTTTSST 476

                          490       500
                   ....*....|....*....|..
gi 1039746333  889 SYIIDSLQPDTTYRIRIQALNS 910
Cdd:COG3401    477 VTATTTDTTTANLSVTTGSLVG 498
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 348-439 8.77e-15

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.99  E-value: 8.77e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  348 PDPPNAPRIANRTKNSLTLQWKAPSDNGSKIQSFILEW-DEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSAKNDY 426
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYrEKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|...
gi 1039746333  427 GVSDFSEEVLYYT 439
Cdd:cd00063     81 GESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
795-1073 4.28e-14

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 76.96  E-value: 4.28e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  795 GLSPATTYYCRVQAMSVVGAGPFS---EVVACVTPPSVPAIVTcLQEISDDDIEyphyspstclaISWKEPYDHGseILA 871
Cdd:COG3401    198 DIEPGTTYYYRVAATDTGGESAPSnevSVTTPTTPPSAPTGLT-ATADTPGSVT-----------LSWDPVTESD--ATG 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  872 YSI-----DLGDKQPLTVGKMTSYIIDSLQPDTTYRIRIQALNSLG-AGPFSHTIKLKTKPLPPDPPR-LECVAFNHQNL 944
Cdd:COG3401    264 YRVyrsnsGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPPAAPSgLTATAVGSSSI 343

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  945 KLKWGEGTpktlSTDAVQYHL-QMEDRNGRFVSLYRGPC-HTYKVQRLSESTSYKFCIQACNEAGEGPLSQEYVFTTPKS 1022
Cdd:COG3401    344 TLSWTASS----DADVTGYNVyRSTSGGGTYTKIAETVTtTSYTDTGLTPGTTYYYKVTAVDAAGNESAPSEEVSATTAS 419

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039746333 1023 LPAA--LKAPKIEKINDHICEITWEYLQPmkGDPVIYNLQVMVGKDSEFKQIY 1073
Cdd:COG3401    420 AASGesLTASVDAVPLTDVAGATAAASAA--SNPGVSAAVLADGGDTGNAVPF 470
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
250-597 1.33e-13

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 75.04  E-value: 1.33e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  250 VASDIQARTVLLTWSPPSSfingevnetavPELFNYEVLVSSTGkEGKYRSVYIGEETSVTLNDLKPATDYHAKVQAE-S 328
Cdd:COG3401    240 TATADTPGSVTLSWDPVTE-----------SDATGYRVYRSNSG-DGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVdA 307

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  329 NSIKGIPSEAESFTTLSCEPDPPNAPRIANRTKNSLTLQWKAPSDNGskIQSFILEWDEGKGnGEFCQ-CYMGSQKQFKI 407
Cdd:COG3401    308 AGNESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWTASSDAD--VTGYNVYRSTSGG-GTYTKiAETVTTTSYTD 384

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  408 TKLSPAMGCKFRLSAKNDYGV-SDFSEEVlyytSGCAPSVPASPVLTKAGVTW---LSLQWTKPSGTPSDEGISYILEME 483
Cdd:COG3401    385 TGLTPGTTYYYKVTAVDAAGNeSAPSEEV----SATTASAASGESLTASVDAVpltDVAGATAAASAASNPGVSAAVLAD 460

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  484 EETSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFSTCPDKPGVPVKPSVKGKIHSHGFKITWD 563
Cdd:COG3401    461 GGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGA 540

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 1039746333  564 PPKD------NGGAPINKYVVEMAEGSNGNKWDMIYSGTT 597
Cdd:COG3401    541 STGDvlitdlVSLTTSASSSVSGAGLGSGNLYLITTLGGS 580
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 444-536 1.74e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 67.14  E-value: 1.74e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  444 PSVPASPVLTKAGVTWLSLQWTKPSGTPSdEGISYILEMEEETSGYGFK-PKYDGEDLAYTVKNLRRSTKYKFKVIAYNS 522
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGG-PITGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                           90
                   ....*....|....
gi 1039746333  523 EGKSNPSEVVEFST 536
Cdd:cd00063     80 GGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 852-924 1.66e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.44  E-value: 1.66e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  852 STCLAISWKEPYDHGSEILAYSI---DLGDKQPLTV----GKMTSYIIDSLQPDTTYRIRIQALNSLGAGPFSHTIKLKT 924
Cdd:cd00063     14 STSVTLSWTPPEDDGGPITGYVVeyrEKGSGDWKEVevtpGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 655-731 1.84e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.44  E-value: 1.84e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039746333  655 EIQLRWGPPQvDGGSPISCYAVEMTPADKDEPRDV--YQGSEVECTVGSLLPGKTYSFRLRAANRIGFGPFSEKYDITT 731
Cdd:cd00063     16 SVTLSWTPPE-DDGGPITGYVVEYREKGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 733-825 7.87e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.51  E-value: 7.87e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  733 PGPPdqcRPPQVTCRSATCAQVNWEIPLSNGTDVTEYRLEWGGV-EGSMQMC--YCGPGLSCELKGLSPATTYYCRVQAM 809
Cdd:cd00063      1 PSPP---TNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKgSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*.
gi 1039746333  810 SVVGAGPFSEVVACVT 825
Cdd:cd00063     78 NGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 541-634 3.23e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.59  E-value: 3.23e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  541 PGVPVKPSVKGkIHSHGFKITWDPPKDNGGaPINKYVVEMAEgSNGNKWDMI--YSGTTREHLCDRLTPGCYYRLRVYCI 618
Cdd:cd00063      1 PSPPTNLRVTD-VTSTSVTLSWTPPEDDGG-PITGYVVEYRE-KGSGDWKEVevTPGSETSYTLTGLKPGTEYEFRVRAV 77

                           90
                   ....*....|....*.
gi 1039746333  619 SDGGQSAVSESLLVQT 634
Cdd:cd00063     78 NGGGESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
849-1131 4.90e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 66.95  E-value: 4.90e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  849 YSPSTCLAISWKEPYDHGSEILAYSIDLGDKQPLTVGKMTSYIIDSLQPDTTYRIRIQALNSLGAGPFSHTIKLKTKPLP 928
Cdd:COG3401    153 ANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTP 232

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  929 PDPP-RLECVAFNHQNLKLKWGEGTpktlSTDAVQYHL-QMEDRNGRFVSLYRGPCHTYKVQRLSESTSYKFCIQACNEA 1006
Cdd:COG3401    233 PSAPtGLTATADTPGSVTLSWDPVT----ESDATGYRVyRSNSGDGPFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAA 308

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333 1007 G-EGPLSQEYVFTTPKSLPAALKAPKIEKINDHICEITWeylQPMKGDPVI-YNLQVMVGKDSEFKQIYKGPD-TSFRYS 1083
Cdd:COG3401    309 GnESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSW---TASSDADVTgYNVYRSTSGGGTYTKIAETVTtTSYTDT 385

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*...
gi 1039746333 1084 SLQLNCEYRFRVCAIrqcqDPTGhqdLVGPYSTTVFFISQRTEPPASS 1131
Cdd:COG3401    386 GLTPGTTYYYKVTAV----DAAG---NESAPSEEVSATTASAASGESL 426
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 244-343 1.54e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.66  E-value: 1.54e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  244 SNIVKPVASDIQARTVLLTWSPPSSfINGEVnetavpelFNYEVLVSSTGKEGKYR-SVYIGEETSVTLNDLKPATDYHA 322
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPED-DGGPI--------TGYVVEYREKGSGDWKEvEVTPGSETSYTLTGLKPGTEYEF 72

                           90       100
                   ....*....|....*....|.
gi 1039746333  323 KVQAESNSIKGIPSEAESFTT 343
Cdd:cd00063     73 RVRAVNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 348-429 1.85e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.31  E-value: 1.85e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333   348 PDPPNAPRIANRTKNSLTLQWKAPSDNG--SKIQSFILEWDEGKGNGEFCQCyMGSQKQFKITKLSPAMGCKFRLSAKND 425
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFRVRAVNG 79


                    ....
gi 1039746333   426 YGVS 429
Cdd:smart00060   80 AGEG 83
fn3 pfam00041
Fibronectin type III domain;
249-336 2.65e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 2.65e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  249 PVASDIQARTVLLTWSPPSSfINGEVNetavpelfNYEVLVSSTGKEGKYRSVYI-GEETSVTLNDLKPATDYHAKVQAE 327
Cdd:pfam00041    6 LTVTDVTSTSLTVSWTPPPD-GNGPIT--------GYEVEYRPKNSGEPWNEITVpGTTTSVTLTGLKPGTEYEVRVQAV 76


                   ....*....
gi 1039746333  328 SNSIKGIPS 336
Cdd:pfam00041   77 NGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
852-917 3.25e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.73  E-value: 3.25e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039746333  852 STCLAISWKEPYDHGSEILAYSI------DLGDKQPLTVGKMT-SYIIDSLQPDTTYRIRIQALNSLGAGPFS 917
Cdd:pfam00041   13 STSLTVSWTPPPDGNGPITGYEVeyrpknSGEPWNEITVPGTTtSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
349-432 3.84e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 54.73  E-value: 3.84e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  349 DPPNAPRIANRTKNSLTLQWKAPSDNGSKIQSFILEWdEGKGNGEFCQCYM--GSQKQFKITKLSPAMGCKFRLSAKNDY 426
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEY-RPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*.
gi 1039746333  427 GVSDFS 432
Cdd:pfam00041   80 GEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 733-815 5.11e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.16  E-value: 5.11e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333   733 PGPPdqcRPPQVTCRSATCAQVNWEIPLSNGTD--VTEYRLEWGGVEGSMQMCYCGPG-LSCELKGLSPATTYYCRVQAM 809
Cdd:smart00060    1 PSPP---SNLRVTDVTSTSVTLSWEPPPDDGITgyIVGYRVEYREEGSEWKEVNVTPSsTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 1039746333   810 SVVGAG 815
Cdd:smart00060   78 NGAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 444-526 8.67e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.39  E-value: 8.67e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333   444 PSVPASPVLTKAGVTWLSLQWTKPsgtPSDEGISYILEMEEETSGYGFKPK---YDGEDLAYTVKNLRRSTKYKFKVIAY 520
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPP---PDDGITGYIVGYRVEYREEGSEWKevnVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                    ....*.
gi 1039746333   521 NSEGKS 526
Cdd:smart00060   78 NGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
740-818 1.08e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.19  E-value: 1.08e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  740 RPPQVTCRSATCAQVNWEIPLSNGTDVTEYRLEW---GGVEGSMQMCYCGPGLSCELKGLSPATTYYCRVQAMSVVGAGP 816
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYrpkNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGP 83


                   ..
gi 1039746333  817 FS 818
Cdd:pfam00041   84 PS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 639-721 1.43e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.00  E-value: 1.43e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333   639 PGPclPPRLQGRPKAKE-IQLRWGPPQVDGG-SPISCYAVEMTPADKDEPRDVYQGSEVECTVGSLLPGKTYSFRLRAAN 716
Cdd:smart00060    1 PSP--PSNLRVTDVTSTsVTLSWEPPPDDGItGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 1039746333   717 RIGFG 721
Cdd:smart00060   79 GAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 852-914 1.91e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.62  E-value: 1.91e-08
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333   852 STCLAISWKEPYDHG--SEILAYSIDLGDKQPL-----TVGKMTSYIIDSLQPDTTYRIRIQALNSLGAG 914
Cdd:smart00060   14 STSVTLSWEPPPDDGitGYIVGYRVEYREEGSEwkevnVTPSSTSYTLTGLKPGTEYEFRVRAVNGAGEG 83
fn3 pfam00041
Fibronectin type III domain;
655-724 3.66e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 51.65  E-value: 3.66e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039746333  655 EIQLRWGPPQvDGGSPISCYAVEMTPADKDEPRDVYQ--GSEVECTVGSLLPGKTYSFRLRAANRIGFGPFS 724
Cdd:pfam00041   15 SLTVSWTPPP-DGNGPITGYEVEYRPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
560-719 1.55e-07

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 55.72  E-value: 1.55e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  560 ITWDPPKDNggapiNKYVVEmAEGSNGNkWDMIYSGTTREHLCDRLTPGCYYrLRVYCISDGGQS----AVSESLLVQTP 635
Cdd:COG4733    556 VSWDAPAGA-----VAYEVE-WRRDDGN-WVSVPRTSGTSFEVPGIYAGDYE-VRVRAINALGVSsawaASSETTVTGKT 627

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  636 AVPPGPclpPRLQGRPKAKEIQLRWGPPqVDGGSP---IScYAVEMTPADKDEPRDVYQGSEVecTVGSLLPGKTYSFRL 712
Cdd:COG4733    628 APPPAP---TGLTATGGLGGITLSWSFP-VDADTLrteIR-YSTTGDWASATVAQALYPGNTY--TLAGLKAGQTYYYRA 700


                   ....*..
gi 1039746333  713 RAANRIG 719
Cdd:COG4733    701 RAVDRSG 707
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 929-1019 2.40e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.80  E-value: 2.40e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  929 PDPPR-LECVAFNHQNLKLKWGEgtPKTLSTDAVQYHLQMEDRNGRFVSLYRGPC---HTYKVQRLSESTSYKFCIQACN 1004
Cdd:cd00063      1 PSPPTnLRVTDVTSTSVTLSWTP--PEDDGGPITGYVVEYREKGSGDWKEVEVTPgseTSYTLTGLKPGTEYEFRVRAVN 78

                           90
                   ....*....|....*
gi 1039746333 1005 EAGEGPLSQEYVFTT 1019
Cdd:cd00063     79 GGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 928-1009 1.53e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 1.53e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333   928 PPDPPRLECVAFNHQNLKLKWGEGTPKTLSTDAVQYHLQMEDRNGRFVSLYRGPCHT-YKVQRLSESTSYKFCIQACNEA 1006
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsYTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 1039746333  1007 GEG 1009
Cdd:smart00060   81 GEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 541-624 1.68e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 47.22  E-value: 1.68e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333   541 PGVPVKPSVKGkIHSHGFKITWDPPK-DNGGAPINKYVVEMAEGSNGNKwDMIYSGTTREHLCDRLTPGCYYRLRVYCIS 619
Cdd:smart00060    1 PSPPSNLRVTD-VTSTSVTLSWEPPPdDGITGYIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 1039746333   620 DGGQS 624
Cdd:smart00060   79 GAGEG 83
fn3 pfam00041
Fibronectin type III domain;
445-529 2.62e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 46.64  E-value: 2.62e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333  445 SVPASPVLTKAGVTWLSLQWTKPSgTPSDEGISYILEMEEETSGYGFKPKYDGEDLA-YTVKNLRRSTKYKFKVIAYNSE 523
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPP-DGNGPITGYEVEYRPKNSGEPWNEITVPGTTTsVTLTGLKPGTEYEVRVQAVNGG 79


                   ....*.
gi 1039746333  524 GKSNPS 529
Cdd:pfam00041   80 GEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 244-329 3.56e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 43.37  E-value: 3.56e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333   244 SNIVKPVASDIQARTVLLTWSPPSSFINGEvnetavpELFNYEVLVSSTGKEGKYRSVyIGEETSVTLNDLKPATDYHAK 323
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITG-------YIVGYRVEYREEGSEWKEVNV-TPSSTSYTLTGLKPGTEYEFR 73


                    ....*.
gi 1039746333   324 VQAESN 329
Cdd:smart00060   74 VRAVNG 79
fn3 pfam00041
Fibronectin type III domain;
555-627 8.70e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 42.40  E-value: 8.70e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039746333  555 SHGFKITWDPPKDNGGaPINKYVVEMAEGSNGNKWDMIY-SGTTREHLCDRLTPGCYYRLRVYCISDGGQSAVS 627
Cdd:pfam00041   13 STSLTVSWTPPPDGNG-PITGYEVEYRPKNSGEPWNEITvPGTTTSVTLTGLKPGTEYEVRVQAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1024-1121 9.00e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 39.79  E-value: 9.00e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039746333 1024 PAALKAPKIEKINDHICEITWEYLQPMKGDPVIYNLQVMVGKDSEFKQIYK--GPDTSFRYSSLQLNCEYRFRVCAIRqc 1101
Cdd:cd00063      1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEFRVRAVN-- 78

                           90       100
                   ....*....|....*....|
gi 1039746333 1102 qdptghQDLVGPYSTTVFFI 1121
Cdd:cd00063     79 ------GGGESPPSESVTVT 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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