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Conserved domains on  [gi|1039748504|ref|XP_017172001|]
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sodium channel protein type 8 subunit alpha isoform X1 [Mus musculus]

Protein Classification

sodium channel protein subunit alpha (domain architecture ID 11999299)

sodium channel protein subunit alpha mediates the voltage-dependent sodium ion permeability of excitable membranes

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
504-710 7.18e-95

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


:

Pssm-ID: 403218  Cd Length: 205  Bit Score: 305.22  E-value: 7.18e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504  504 SEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRIGR--KFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGpgRFRDPGSEN 581
Cdd:pfam11933    1 SEGEEKGDDEKVPKSESEDSIRRKGFRFSVDRLAYkkKFSSPNQSLLSIPGSPFSPRRNSRGSIFSFRG--RGRDAGSEN 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504  582 EFADDEHSTVEESEGRRDSLFIPiRARERRssysgYSGYSQCSRSSRIFPSLRRSVKRNSTVDCNGVVSLIG----PGSH 657
Cdd:pfam11933   79 DFADDENSTFEDSESRRGSLFVP-RRHERR-----SSYTSQASRSSRSHPGLPQNGKRHSTVDCNGVVSLVGggpePTSP 152
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039748504  658 IGRLLPEVKIDKAATDSATTEVEIKKKGPGSLLVSMEQLASYGRKDRINSIMS 710
Cdd:pfam11933  153 GGLLLPEVIIDGSDDGTTTTESEIRKKRSGSLQVSMDFLEEPGQRQRAVSAVS 205
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
999-1200 1.18e-68

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


:

Pssm-ID: 399489  Cd Length: 201  Bit Score: 229.94  E-value: 1.18e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504  999 DGEMNNLQISVIRIKKGVAWAKVKVHAFMQAHF--KQREADEVKPLDELYE--KKANCIANHTGVdiHRNGDFQKNGngt 1074
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKRTLRDFCCRLCllEPQKLPEKKPLDESKDasKKTNQIANHTSA--PKELKKAPGG--- 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504 1075 tsgigssveKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSE-SDPEGSKDKL-----DDTSSSEGSTIDIK 1148
Cdd:pfam06512   76 ---------KYGVDEDHMSFITNPNLTVCVPIAEGESDLENEEDEDESSQsSDEEKSKQQEqlqqvDDSSSSEGSTVDLT 146
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039748504 1149 PEVEEVPVEQPEE--YLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCF 1200
Cdd:pfam06512  147 DPEEELEQIPEEAedLKEPEDCFPEGCVRRFPCCAVDITKGPWKIWWNLRKTCY 200
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1205-1481 3.63e-64

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 218.29  E-value: 3.63e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504 1205 HNWFETFIIFMILLSSGALAFEDIYIEQRKTIrTILEYADKVFTYIFILEMLLKWTAYGFVK-FFTNAWCWLDFLIVAVS 1283
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLT-TVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504 1284 LVSLIANalGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYhy 1363
Cdd:pfam00520   80 LISLVLS--SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504 1364 cfnetseirfeidevnnktdceklmegnNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRkpdeqpdye 1443
Cdd:pfam00520  156 ----------------------------KTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK--------- 198
                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1039748504 1444 GNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1481
Cdd:pfam00520  199 GEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1530-1784 1.75e-57

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 199.42  E-value: 1.75e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504 1530 QAFDIVIMMLICLNMVTMMVETDTQSKQ-MENILYWINLVFVIFFTCECVLKMFALR--HYYFTIGWNIFDFVVVILSIV 1606
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGfkKRYFRSPWNILDFVVVLPSLI 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504 1607 GMFLADIiekyfVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYV-- 1684
Cdd:pfam00520   82 SLVLSSV-----GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlk 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504 1685 KHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPdcsldkehpgsgfkgdcgnPSVGIFFFVSYIIISFLI 1764
Cdd:pfam00520  157 TWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-------------------EFWAYIYFVSFIILGGFL 217
                          250       260
                   ....*....|....*....|
gi 1039748504 1765 VVNMYIAIILENFSVATEES 1784
Cdd:pfam00520  218 LLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
760-973 2.19e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 193.25  E-value: 2.19e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504  760 DPFVDLAITICIVLNTLFMAMEHHPMTPQ-FEHVLAVGNLVFTGIFTAEMFLKLIAMDP-YYYFQEGWNIFDGFIVSLSL 837
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504  838 MELGLADVE---GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYkecvc 914
Cdd:pfam00520   81 ISLVLSSVGslsGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----- 155
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504  915 KISQECKLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVFMMVMVIGN 973
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
131-421 9.07e-50

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 177.07  E-value: 9.07e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504  131 HSVFSMIIMCTILTNCVFMTFSNPPE-------WSKNVEYTFTGIYTFESLVKIIARGFCidgFTFLRDPWNWLDFSVIM 203
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQpeeplttVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504  204 MAYVT----EFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRN 279
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504  280 kcvvwpinfnesylengtrgfdweeyinnktnfymvpgmlepllcgnssdagqcpegfqcmkaGRNPNYGYTSFDTFSWA 359
Cdd:pfam00520  158 ---------------------------------------------------------------WENPDNGRTNFDNFPNA 174
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039748504  360 FLALFRLMTQDYWENLYQLTLRAAGKTYM-IFFVLVIFVGSFYLVNLILAVVAMAYEEQNQAT 421
Cdd:pfam00520  175 FLWLFQTMTTEGWGDIMYDTIDGKGEFWAyIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1473-1525 3.16e-31

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


:

Pssm-ID: 240441  Cd Length: 54  Bit Score: 116.90  E-value: 3.16e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039748504 1473 DNFNQQKKKFGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFD 1525
Cdd:cd13433      1 DNFNQLKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
1902-1923 1.43e-03

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


:

Pssm-ID: 197470  Cd Length: 23  Bit Score: 37.69  E-value: 1.43e-03
                            10        20
                    ....*....|....*....|..
gi 1039748504  1902 QEEVSAVVLQRAYRGHLARRGF 1923
Cdd:smart00015    1 RLTRAAIIIQAAWRGYLARKRY 22
GPHH super family cl25190
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1796-1843 4.64e-03

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


The actual alignment was detected with superfamily member pfam16905:

Pssm-ID: 407139  Cd Length: 54  Bit Score: 36.86  E-value: 4.64e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039748504 1796 FYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPK--PNTI---ELIAMDLP 1843
Cdd:pfam16905    2 FVRIWAEYDPAATGRISYQDMYELLRRISPPLGFGKkcPARVaykRLVRMNMP 54
 
Name Accession Description Interval E-value
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
504-710 7.18e-95

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


Pssm-ID: 403218  Cd Length: 205  Bit Score: 305.22  E-value: 7.18e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504  504 SEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRIGR--KFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGpgRFRDPGSEN 581
Cdd:pfam11933    1 SEGEEKGDDEKVPKSESEDSIRRKGFRFSVDRLAYkkKFSSPNQSLLSIPGSPFSPRRNSRGSIFSFRG--RGRDAGSEN 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504  582 EFADDEHSTVEESEGRRDSLFIPiRARERRssysgYSGYSQCSRSSRIFPSLRRSVKRNSTVDCNGVVSLIG----PGSH 657
Cdd:pfam11933   79 DFADDENSTFEDSESRRGSLFVP-RRHERR-----SSYTSQASRSSRSHPGLPQNGKRHSTVDCNGVVSLVGggpePTSP 152
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039748504  658 IGRLLPEVKIDKAATDSATTEVEIKKKGPGSLLVSMEQLASYGRKDRINSIMS 710
Cdd:pfam11933  153 GGLLLPEVIIDGSDDGTTTTESEIRKKRSGSLQVSMDFLEEPGQRQRAVSAVS 205
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
999-1200 1.18e-68

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 399489  Cd Length: 201  Bit Score: 229.94  E-value: 1.18e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504  999 DGEMNNLQISVIRIKKGVAWAKVKVHAFMQAHF--KQREADEVKPLDELYE--KKANCIANHTGVdiHRNGDFQKNGngt 1074
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKRTLRDFCCRLCllEPQKLPEKKPLDESKDasKKTNQIANHTSA--PKELKKAPGG--- 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504 1075 tsgigssveKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSE-SDPEGSKDKL-----DDTSSSEGSTIDIK 1148
Cdd:pfam06512   76 ---------KYGVDEDHMSFITNPNLTVCVPIAEGESDLENEEDEDESSQsSDEEKSKQQEqlqqvDDSSSSEGSTVDLT 146
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039748504 1149 PEVEEVPVEQPEE--YLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCF 1200
Cdd:pfam06512  147 DPEEELEQIPEEAedLKEPEDCFPEGCVRRFPCCAVDITKGPWKIWWNLRKTCY 200
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1205-1481 3.63e-64

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 218.29  E-value: 3.63e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504 1205 HNWFETFIIFMILLSSGALAFEDIYIEQRKTIrTILEYADKVFTYIFILEMLLKWTAYGFVK-FFTNAWCWLDFLIVAVS 1283
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLT-TVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504 1284 LVSLIANalGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYhy 1363
Cdd:pfam00520   80 LISLVLS--SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504 1364 cfnetseirfeidevnnktdceklmegnNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRkpdeqpdye 1443
Cdd:pfam00520  156 ----------------------------KTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK--------- 198
                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1039748504 1444 GNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1481
Cdd:pfam00520  199 GEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1530-1784 1.75e-57

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 199.42  E-value: 1.75e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504 1530 QAFDIVIMMLICLNMVTMMVETDTQSKQ-MENILYWINLVFVIFFTCECVLKMFALR--HYYFTIGWNIFDFVVVILSIV 1606
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGfkKRYFRSPWNILDFVVVLPSLI 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504 1607 GMFLADIiekyfVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYV-- 1684
Cdd:pfam00520   82 SLVLSSV-----GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlk 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504 1685 KHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPdcsldkehpgsgfkgdcgnPSVGIFFFVSYIIISFLI 1764
Cdd:pfam00520  157 TWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-------------------EFWAYIYFVSFIILGGFL 217
                          250       260
                   ....*....|....*....|
gi 1039748504 1765 VVNMYIAIILENFSVATEES 1784
Cdd:pfam00520  218 LLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
760-973 2.19e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 193.25  E-value: 2.19e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504  760 DPFVDLAITICIVLNTLFMAMEHHPMTPQ-FEHVLAVGNLVFTGIFTAEMFLKLIAMDP-YYYFQEGWNIFDGFIVSLSL 837
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504  838 MELGLADVE---GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYkecvc 914
Cdd:pfam00520   81 ISLVLSSVGslsGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----- 155
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504  915 KISQECKLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVFMMVMVIGN 973
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
131-421 9.07e-50

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 177.07  E-value: 9.07e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504  131 HSVFSMIIMCTILTNCVFMTFSNPPE-------WSKNVEYTFTGIYTFESLVKIIARGFCidgFTFLRDPWNWLDFSVIM 203
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQpeeplttVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504  204 MAYVT----EFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRN 279
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504  280 kcvvwpinfnesylengtrgfdweeyinnktnfymvpgmlepllcgnssdagqcpegfqcmkaGRNPNYGYTSFDTFSWA 359
Cdd:pfam00520  158 ---------------------------------------------------------------WENPDNGRTNFDNFPNA 174
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039748504  360 FLALFRLMTQDYWENLYQLTLRAAGKTYM-IFFVLVIFVGSFYLVNLILAVVAMAYEEQNQAT 421
Cdd:pfam00520  175 FLWLFQTMTTEGWGDIMYDTIDGKGEFWAyIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1473-1525 3.16e-31

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 116.90  E-value: 3.16e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039748504 1473 DNFNQQKKKFGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFD 1525
Cdd:cd13433      1 DNFNQLKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
1902-1923 1.43e-03

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470  Cd Length: 23  Bit Score: 37.69  E-value: 1.43e-03
                            10        20
                    ....*....|....*....|..
gi 1039748504  1902 QEEVSAVVLQRAYRGHLARRGF 1923
Cdd:smart00015    1 RLTRAAIIIQAAWRGYLARKRY 22
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1796-1843 4.64e-03

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 407139  Cd Length: 54  Bit Score: 36.86  E-value: 4.64e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039748504 1796 FYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPK--PNTI---ELIAMDLP 1843
Cdd:pfam16905    2 FVRIWAEYDPAATGRISYQDMYELLRRISPPLGFGKkcPARVaykRLVRMNMP 54
 
Name Accession Description Interval E-value
Na_trans_cytopl pfam11933
Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain ...
504-710 7.18e-95

Cytoplasmic domain of voltage-gated Na+ ion channel; This is a large cytoplasmic domain towards the start of voltage-dependent sodium ion channel proteins in eukaryotes. It is found closely associated with pfam06512 and pfam00520.


Pssm-ID: 403218  Cd Length: 205  Bit Score: 305.22  E-value: 7.18e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504  504 SEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRIGR--KFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGpgRFRDPGSEN 581
Cdd:pfam11933    1 SEGEEKGDDEKVPKSESEDSIRRKGFRFSVDRLAYkkKFSSPNQSLLSIPGSPFSPRRNSRGSIFSFRG--RGRDAGSEN 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504  582 EFADDEHSTVEESEGRRDSLFIPiRARERRssysgYSGYSQCSRSSRIFPSLRRSVKRNSTVDCNGVVSLIG----PGSH 657
Cdd:pfam11933   79 DFADDENSTFEDSESRRGSLFVP-RRHERR-----SSYTSQASRSSRSHPGLPQNGKRHSTVDCNGVVSLVGggpePTSP 152
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039748504  658 IGRLLPEVKIDKAATDSATTEVEIKKKGPGSLLVSMEQLASYGRKDRINSIMS 710
Cdd:pfam11933  153 GGLLLPEVIIDGSDDGTTTTESEIRKKRSGSLQVSMDFLEEPGQRQRAVSAVS 205
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
999-1200 1.18e-68

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 399489  Cd Length: 201  Bit Score: 229.94  E-value: 1.18e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504  999 DGEMNNLQISVIRIKKGVAWAKVKVHAFMQAHF--KQREADEVKPLDELYE--KKANCIANHTGVdiHRNGDFQKNGngt 1074
Cdd:pfam06512    1 DGEMNNLQIALARIQRGIRFVKRTLRDFCCRLCllEPQKLPEKKPLDESKDasKKTNQIANHTSA--PKELKKAPGG--- 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504 1075 tsgigssveKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSE-SDPEGSKDKL-----DDTSSSEGSTIDIK 1148
Cdd:pfam06512   76 ---------KYGVDEDHMSFITNPNLTVCVPIAEGESDLENEEDEDESSQsSDEEKSKQQEqlqqvDDSSSSEGSTVDLT 146
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039748504 1149 PEVEEVPVEQPEE--YLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCF 1200
Cdd:pfam06512  147 DPEEELEQIPEEAedLKEPEDCFPEGCVRRFPCCAVDITKGPWKIWWNLRKTCY 200
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1205-1481 3.63e-64

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 218.29  E-value: 3.63e-64
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504 1205 HNWFETFIIFMILLSSGALAFEDIYIEQRKTIrTILEYADKVFTYIFILEMLLKWTAYGFVK-FFTNAWCWLDFLIVAVS 1283
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLT-TVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504 1284 LVSLIANalGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYhy 1363
Cdd:pfam00520   80 LISLVLS--SVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL-- 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504 1364 cfnetseirfeidevnnktdceklmegnNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRkpdeqpdye 1443
Cdd:pfam00520  156 ----------------------------KTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK--------- 198
                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1039748504 1444 GNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKK 1481
Cdd:pfam00520  199 GEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1530-1784 1.75e-57

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 199.42  E-value: 1.75e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504 1530 QAFDIVIMMLICLNMVTMMVETDTQSKQ-MENILYWINLVFVIFFTCECVLKMFALR--HYYFTIGWNIFDFVVVILSIV 1606
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGfkKRYFRSPWNILDFVVVLPSLI 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504 1607 GMFLADIiekyfVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYV-- 1684
Cdd:pfam00520   82 SLVLSSV-----GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKlk 156
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504 1685 KHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPdcsldkehpgsgfkgdcgnPSVGIFFFVSYIIISFLI 1764
Cdd:pfam00520  157 TWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-------------------EFWAYIYFVSFIILGGFL 217
                          250       260
                   ....*....|....*....|
gi 1039748504 1765 VVNMYIAIILENFSVATEES 1784
Cdd:pfam00520  218 LLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
760-973 2.19e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 193.25  E-value: 2.19e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504  760 DPFVDLAITICIVLNTLFMAMEHHPMTPQ-FEHVLAVGNLVFTGIFTAEMFLKLIAMDP-YYYFQEGWNIFDGFIVSLSL 837
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504  838 MELGLADVE---GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYkecvc 914
Cdd:pfam00520   81 ISLVLSSVGslsGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----- 155
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504  915 KISQECKLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQAMCLIVFMMVMVIGN 973
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
131-421 9.07e-50

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 177.07  E-value: 9.07e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504  131 HSVFSMIIMCTILTNCVFMTFSNPPE-------WSKNVEYTFTGIYTFESLVKIIARGFCidgFTFLRDPWNWLDFSVIM 203
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQpeeplttVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504  204 MAYVT----EFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRN 279
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504  280 kcvvwpinfnesylengtrgfdweeyinnktnfymvpgmlepllcgnssdagqcpegfqcmkaGRNPNYGYTSFDTFSWA 359
Cdd:pfam00520  158 ---------------------------------------------------------------WENPDNGRTNFDNFPNA 174
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039748504  360 FLALFRLMTQDYWENLYQLTLRAAGKTYM-IFFVLVIFVGSFYLVNLILAVVAMAYEEQNQAT 421
Cdd:pfam00520  175 FLWLFQTMTTEGWGDIMYDTIDGKGEFWAyIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1473-1525 3.16e-31

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 116.90  E-value: 3.16e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039748504 1473 DNFNQQKKKFGG-QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFD 1525
Cdd:cd13433      1 DNFNQLKKKYGGgLDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 ...
1548-1778 3.01e-08

Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 proteins.


Pssm-ID: 400395  Cd Length: 424  Bit Score: 58.12  E-value: 3.01e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504 1548 MVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLAdiIEKYFVSPTLFRVI 1627
Cdd:pfam08016  198 LLRYVTNRSLFILLCEIVFVVFFLYFVVEEILKIRKHRPSYLRSVWNLLDLAIVILSVVLIVLN--IYRDFLVDRLIKSV 275
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504 1628 -----------RLARIGRILRLIKG----------------AKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSN 1680
Cdd:pfam08016  276 easpvtfidfdRVAQLDNLYRIILAflvfltwlklfkvlrfNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLL 355
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039748504 1681 FAyvKHEAgiddmfNFETFGNSMICLFQITTSA-GWDGLllpilnrppdcsldkehpgsgfkgDCGNPSVGIFFFVSYII 1759
Cdd:pfam08016  356 FG--TQAP------NFSNFVKSILTLFRTILGDfGYNEI------------------------FSGNRVLGPLLFLTFVF 403
                          250
                   ....*....|....*....
gi 1039748504 1760 ISFLIVVNMYIAIILENFS 1778
Cdd:pfam08016  404 LVIFILLNLFLAIINDSYV 422
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
1902-1923 1.43e-03

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470  Cd Length: 23  Bit Score: 37.69  E-value: 1.43e-03
                            10        20
                    ....*....|....*....|..
gi 1039748504  1902 QEEVSAVVLQRAYRGHLARRGF 1923
Cdd:smart00015    1 RLTRAAIIIQAAWRGYLARKRY 22
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
1796-1843 4.64e-03

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 407139  Cd Length: 54  Bit Score: 36.86  E-value: 4.64e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039748504 1796 FYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPK--PNTI---ELIAMDLP 1843
Cdd:pfam16905    2 FVRIWAEYDPAATGRISYQDMYELLRRISPPLGFGKkcPARVaykRLVRMNMP 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.19
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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