NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1039749232|ref|XP_017172190|]
View 

WD repeat-containing protein 70 isoform X2 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-285 9.04e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 103.18  E-value: 9.04e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232  17 HQIKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMECIKG-------------DQYIV----------------DMANT- 66
Cdd:cd00200    10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGhtgpvrdvaasadGTYLAsgssdktirlwdletgECVRTl 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232  67 KGHTAMLHTGSWHPKikGEFM-TCSNDATVRLWEVENPKKQKsvfkprTMQGKKVIPTTCTYSRDGNLVAAACQNGSIQI 145
Cdd:cd00200    90 TGHTSYVSSVAFSPD--GRILsSSSRDKTIKVWDVETGKCLT------TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232 146 WD-------RNLTVHpkfhykqahdpgTDT-SCVAFSYDGNVLASRGGDDTLKLWDVRQFN--KPLFSASDlptlfPMTD 215
Cdd:cd00200   162 WDlrtgkcvATLTGH------------TGEvNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKclGTLRGHEN-----GVNS 224

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232 216 CCFSPDDKLIVTGTsvqrgcGSGKLVFLERRTFQRVYEIHITDASVVRCLWHPKLNQIMVGTGNGLAKVY 285
Cdd:cd00200   225 VAFSPDGYLLASGS------EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-285 9.04e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.18  E-value: 9.04e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232  17 HQIKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMECIKG-------------DQYIV----------------DMANT- 66
Cdd:cd00200    10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGhtgpvrdvaasadGTYLAsgssdktirlwdletgECVRTl 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232  67 KGHTAMLHTGSWHPKikGEFM-TCSNDATVRLWEVENPKKQKsvfkprTMQGKKVIPTTCTYSRDGNLVAAACQNGSIQI 145
Cdd:cd00200    90 TGHTSYVSSVAFSPD--GRILsSSSRDKTIKVWDVETGKCLT------TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232 146 WD-------RNLTVHpkfhykqahdpgTDT-SCVAFSYDGNVLASRGGDDTLKLWDVRQFN--KPLFSASDlptlfPMTD 215
Cdd:cd00200   162 WDlrtgkcvATLTGH------------TGEvNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKclGTLRGHEN-----GVNS 224

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232 216 CCFSPDDKLIVTGTsvqrgcGSGKLVFLERRTFQRVYEIHITDASVVRCLWHPKLNQIMVGTGNGLAKVY 285
Cdd:cd00200   225 VAFSPDGYLLASGS------EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
19-230 9.19e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 9.19e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232  19 IKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMecikgdqyivdmANTKGHTAMLHTGSWHPKikGEFM-TCSNDATVRL 97
Cdd:COG2319   165 VTSVAFSPDGKLLASGSDDGTVRLWDLATGKLL------------RTLTGHTGAVRSVAFSPD--GKLLaSGSADGTVRL 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232  98 WEVENPKKqksvfkPRTMQGKKVIPTTCTYSRDGNLVAAACQNGSIQIWDRNltvHPKFHYKQAHDPGTDTScVAFSYDG 177
Cdd:COG2319   231 WDLATGKL------LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA---TGELLRTLTGHSGGVNS-VAFSPDG 300

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1039749232 178 NVLASRGGDDTLKLWDVRQfNKPLFSASDLPTlfPMTDCCFSPDDKLIVTGTS 230
Cdd:COG2319   301 KLLASGSDDGTVRLWDLAT-GKLLRTLTGHTG--AVRSVAFSPDGKTLASGSD 350
PTZ00420 PTZ00420
coronin; Provisional
 67-205 3.33e-09

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 58.81  E-value: 3.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232  67 KGHTAMLHTGSWHPKikGEFMTCSN--DATVRLWEVENPKKQKSVFKPRTMQGKKvipttctYSRDGNLVAAACQNGSIQ 144
Cdd:PTZ00420  122 KGHKKKISIIDWNPM--NYYIMCSSgfDSFVNIWDIENEKRAFQINMPKKLSSLK-------WNIKGNLLSGTCVGKHMH 192

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039749232 145 IWD-RNLTVHPKFHykqAHDPGTDTSCV---AFSYDGNVLASRGGDDT----LKLWDVRQFNKPLFSAS 205
Cdd:PTZ00420  193 IIDpRKQEIASSFH---IHDGGKNTKNIwidGLGGDDNYILSTGFSKNnmreMKLWDLKNTTSALVTMS 258
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 169-193 2.87e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 2.87e-03
                           10        20
                   ....*....|....*....|....*
gi 1039749232  169 SCVAFSYDGNVLASRGGDDTLKLWD 193
Cdd:smart00320  16 TSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
169-193 4.77e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 4.77e-03
                          10        20
                  ....*....|....*....|....*
gi 1039749232 169 SCVAFSYDGNVLASRGGDDTLKLWD 193
Cdd:pfam00400  15 TSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-285 9.04e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.18  E-value: 9.04e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232  17 HQIKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMECIKG-------------DQYIV----------------DMANT- 66
Cdd:cd00200    10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGhtgpvrdvaasadGTYLAsgssdktirlwdletgECVRTl 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232  67 KGHTAMLHTGSWHPKikGEFM-TCSNDATVRLWEVENPKKQKsvfkprTMQGKKVIPTTCTYSRDGNLVAAACQNGSIQI 145
Cdd:cd00200    90 TGHTSYVSSVAFSPD--GRILsSSSRDKTIKVWDVETGKCLT------TLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232 146 WD-------RNLTVHpkfhykqahdpgTDT-SCVAFSYDGNVLASRGGDDTLKLWDVRQFN--KPLFSASDlptlfPMTD 215
Cdd:cd00200   162 WDlrtgkcvATLTGH------------TGEvNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKclGTLRGHEN-----GVNS 224

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232 216 CCFSPDDKLIVTGTsvqrgcGSGKLVFLERRTFQRVYEIHITDASVVRCLWHPKLNQIMVGTGNGLAKVY 285
Cdd:cd00200   225 VAFSPDGYLLASGS------EDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
19-230 9.19e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 9.19e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232  19 IKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMecikgdqyivdmANTKGHTAMLHTGSWHPKikGEFM-TCSNDATVRL 97
Cdd:COG2319   165 VTSVAFSPDGKLLASGSDDGTVRLWDLATGKLL------------RTLTGHTGAVRSVAFSPD--GKLLaSGSADGTVRL 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232  98 WEVENPKKqksvfkPRTMQGKKVIPTTCTYSRDGNLVAAACQNGSIQIWDRNltvHPKFHYKQAHDPGTDTScVAFSYDG 177
Cdd:COG2319   231 WDLATGKL------LRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA---TGELLRTLTGHSGGVNS-VAFSPDG 300

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1039749232 178 NVLASRGGDDTLKLWDVRQfNKPLFSASDLPTlfPMTDCCFSPDDKLIVTGTS 230
Cdd:COG2319   301 KLLASGSDDGTVRLWDLAT-GKLLRTLTGHTG--AVRSVAFSPDGKTLASGSD 350
WD40 COG2319
WD40 repeat [General function prediction only];
19-228 1.65e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 95.75  E-value: 1.65e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232  19 IKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMecikgdqyivdmANTKGHTAMLHTGSWHPKikGEFM-TCSNDATVRL 97
Cdd:COG2319   207 VRSVAFSPDGKLLASGSADGTVRLWDLATGKLL------------RTLTGHSGSVRSVAFSPD--GRLLaSGSADGTVRL 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232  98 WEVENPKKqksvfkPRTMQGKKVIPTTCTYSRDGNLVAAACQNGSIQIWDRNLTVHPKFHykQAHDPgtDTSCVAFSYDG 177
Cdd:COG2319   273 WDLATGEL------LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL--TGHTG--AVRSVAFSPDG 342

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1039749232 178 NVLASRGGDDTLKLWDVRqfnkplfSASDLPTLF----PMTDCCFSPDDKLIVTG 228
Cdd:COG2319   343 KTLASGSDDGTVRLWDLA-------TGELLRTLTghtgAVTSVAFSPDGRTLASG 390
WD40 COG2319
WD40 repeat [General function prediction only];
67-285 5.34e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.21  E-value: 5.34e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232  67 KGHTAMLHTGSWHPKikGEFM-TCSNDATVRLWEVENPKKqksvfkPRTMQGKKVIPTTCTYSRDGNLVAAACQNGSIQI 145
Cdd:COG2319   117 TGHTGAVRSVAFSPD--GKTLaSGSADGTVRLWDLATGKL------LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232 146 WD-------RNLTVHPKFHYkqahdpgtdtsCVAFSYDGNVLASRGGDDTLKLWDVRQfNKPLFSASDLPtlFPMTDCCF 218
Cdd:COG2319   189 WDlatgkllRTLTGHTGAVR-----------SVAFSPDGKLLASGSADGTVRLWDLAT-GKLLRTLTGHS--GSVRSVAF 254

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039749232 219 SPDDKLIVTGTsvqrgcGSGKLVFLERRTFQRVYEIHITDASVVRCLWHPKLNQIMVGTGNGLAKVY 285
Cdd:COG2319   255 SPDGRLLASGS------ADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 67-285 3.71e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.09  E-value: 3.71e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232  67 KGHTAMLHTGSWHPKikGEFM-TCSNDATVRLWEVENPKKQksvfkpRTMQGKKVIPTTCTYSRDGNLVAAACQNGSIQI 145
Cdd:cd00200     6 KGHTGGVTCVAFSPD--GKLLaTGSGDGTIKVWDLETGELL------RTLKGHTGPVRDVAASADGTYLASGSSDKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232 146 WD-------RNLTVHPKfhykqahdpgtDTSCVAFSYDGNVLASRGGDDTLKLWDVRQFN--KPLFSASDlptlfPMTDC 216
Cdd:cd00200    78 WDletgecvRTLTGHTS-----------YVSSVAFSPDGRILSSSSRDKTIKVWDVETGKclTTLRGHTD-----WVNSV 141

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232 217 CFSPDDKLIVTGTSVqrgcGSGKLVFLERRTFQRVYEIHItdaSVVRCL-WHPKLNQIMVGTGNGLAKVY 285
Cdd:cd00200   142 AFSPDGTFVASSSQD----GTIKLWDLRTGKCVATLTGHT---GEVNSVaFSPDGEKLLSSSSDGTIKLW 204
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-193 2.85e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.78  E-value: 2.85e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232   4 SFKAFRSLQPCECHQ--IKSLQYSNTGDMILVVSGSSQAKVIDrdgFEVMECIKgdqyivdmaNTKGHTAMLHTGSWHPK 81
Cdd:cd00200   121 DVETGKCLTTLRGHTdwVNSVAFSPDGTFVASSSQDGTIKLWD---LRTGKCVA---------TLTGHTGEVNSVAFSPD 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232  82 iKGEFMTCSNDATVRLWEVENPKKQKsvfkprTMQGKKVIPTTCTYSRDGNLVAAACQNGSIQIWD-RNLTVHPKFhykQ 160
Cdd:cd00200   189 -GEKLLSSSSDGTIKLWDLSTGKCLG------TLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDlRTGECVQTL---S 258

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1039749232 161 AHDPGTdtSCVAFSYDGNVLASRGGDDTLKLWD 193
Cdd:cd00200   259 GHTNSV--TSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
18-195 2.06e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.50  E-value: 2.06e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232  18 QIKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMECIKGdqyivdmantkgHTAMLHTGSWHPKikGEFM-TCSNDATVR 96
Cdd:COG2319   248 SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG------------HSGGVNSVAFSPD--GKLLaSGSDDGTVR 313

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232  97 LWEVENPKKqksvfkPRTMQGKKVIPTTCTYSRDGNLVAAACQNGSIQIWDRNlTVHPKFHYKQAHDPGTDtscVAFSYD 176
Cdd:COG2319   314 LWDLATGKL------LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA-TGELLRTLTGHTGAVTS---VAFSPD 383

                         170
                  ....*....|....*....
gi 1039749232 177 GNVLASRGGDDTLKLWDVR 195
Cdd:COG2319   384 GRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
68-285 8.46e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 84.96  E-value: 8.46e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232  68 GHTAMLHTGSWHPKIKGeFMTCSNDATVRLWEVENPKKqksvfkPRTMQGKKVIPTTCTYSRDGNLVAAACQNGSIQIWD 147
Cdd:COG2319    76 GHTAAVLSVAFSPDGRL-LASASADGTVRLWDLATGLL------LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232 148 -------RNLTVHPKfhykqahdpgtDTSCVAFSYDGNVLASRGGDDTLKLWDVRqfnkplfSASDLPTL----FPMTDC 216
Cdd:COG2319   149 latgkllRTLTGHSG-----------AVTSVAFSPDGKLLASGSDDGTVRLWDLA-------TGKLLRTLtghtGAVRSV 210

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232 217 CFSPDDKLIVTGtsvqrgcGSGKLVFL-ERRTFQRVYEIHITDASVVRCLWHPKLNQIMVGTGNGLAKVY 285
Cdd:COG2319   211 AFSPDGKLLASG-------SADGTVRLwDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 113-285 2.47e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.97  E-value: 2.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232 113 RTMQGKKVIPTTCTYSRDGNLVAAACQNGSIQIWDRNlTVHPKFHYKQAHDPGTDTSCVAfsyDGNVLASRGGDDTLKLW 192
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-TGELLRTLKGHTGPVRDVAASA---DGTYLASGSSDKTIRLW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232 193 DVRQfNKPLFsasdlpTLF----PMTDCCFSPDDKLIVTGTSvqrgcgSGKLVFLERRTFQRVYEIHITDASVVRCLWHP 268
Cdd:cd00200    79 DLET-GECVR------TLTghtsYVSSVAFSPDGRILSSSSR------DKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP 145

                         170
                  ....*....|....*..
gi 1039749232 269 KLNQIMVGTGNGLAKVY 285
Cdd:cd00200   146 DGTFVASSSQDGTIKLW 162
PTZ00420 PTZ00420
coronin; Provisional
 67-205 3.33e-09

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 58.81  E-value: 3.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232  67 KGHTAMLHTGSWHPKikGEFMTCSN--DATVRLWEVENPKKQKSVFKPRTMQGKKvipttctYSRDGNLVAAACQNGSIQ 144
Cdd:PTZ00420  122 KGHKKKISIIDWNPM--NYYIMCSSgfDSFVNIWDIENEKRAFQINMPKKLSSLK-------WNIKGNLLSGTCVGKHMH 192

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039749232 145 IWD-RNLTVHPKFHykqAHDPGTDTSCV---AFSYDGNVLASRGGDDT----LKLWDVRQFNKPLFSAS 205
Cdd:PTZ00420  193 IIDpRKQEIASSFH---IHDGGKNTKNIwidGLGGDDNYILSTGFSKNnmreMKLWDLKNTTSALVTMS 258
WD40 COG2319
WD40 repeat [General function prediction only];
127-230 1.07e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.60  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232 127 YSRDGNLVAAACQNGSIQIWDRNLTVHPKfhykQAHDPGTDTSCVAFSYDGNVLASRGGDDTLKLWDVRQfnkPLFSASD 206
Cdd:COG2319    44 ASPDGARLAAGAGDLTLLLLDAAAGALLA----TLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT---GLLLRTL 116

                          90       100
                  ....*....|....*....|....
gi 1039749232 207 LPTLFPMTDCCFSPDDKLIVTGTS 230
Cdd:COG2319   117 TGHTGAVRSVAFSPDGKTLASGSA 140
CDC55 COG5170
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];
85-229 6.50e-04

Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];


Pssm-ID: 227498 [Multi-domain]  Cd Length: 460  Bit Score: 41.94  E-value: 6.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232  85 EFMTCSNDATVRLWEVENPKKQKSV--FKPRTMQG-KKVIPTTCTYSRDGNLVAAACQNGSIQIWD---RNLTVHPKFHY 158
Cdd:COG5170   185 ETLLSADDLRINLWNLEIIDGSFNIvdIKPHNMEElTEVITSAEFHPEMCNVFMYSSSKGEIKLNDlrqSALCDNSKKLF 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039749232 159 KQAHDPG---------TDTSCVAFSYDGNVLASRGGDdTLKLWDVRQFNKPLFSASDLPTL-------------FPMTDC 216
Cdd:COG5170   265 ELTIDGVdvdffeeivSSISDFKFSDNGRYILSRDYL-TVKIWDVNMAKNPIKTIPMHCDLmdelndvyendaiFDKFEI 343

                         170
                  ....*....|...
gi 1039749232 217 CFSPDDKLIVTGT 229
Cdd:COG5170   344 SFSGDDKHVLSGS 356
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 169-193 2.87e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 2.87e-03
                           10        20
                   ....*....|....*....|....*
gi 1039749232  169 SCVAFSYDGNVLASRGGDDTLKLWD 193
Cdd:smart00320  16 TSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
169-193 4.77e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 4.77e-03
                          10        20
                  ....*....|....*....|....*
gi 1039749232 169 SCVAFSYDGNVLASRGGDDTLKLWD 193
Cdd:pfam00400  15 TSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH