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Conserved domains on  [gi|1039756377|ref|XP_017173460|]
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synphilin-1 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
306-448 1.46e-13

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 72.29  E-value: 1.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756377 306 QGTEERTEYLKKVRSILNIVNEGQISLL-----NGQLECVRWMVsetEAIAEL-SCSKDFPSLIHYAGCYGQEKILLWLL 379
Cdd:COG0666    97 NGDLEIVKLLLEAGADVNARDKDGETPLhlaayNGNLEIVKLLL---EAGADVnAQDNDGNTPLHLAAANGNLEIVKLLL 173

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039756377 380 qfmqEQGISLDEVDREGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERHGHTLCSRYL 448
Cdd:COG0666   174 ----EAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLL 238
SNCAIP_SNCA_bd super family cl25051
Synphilin-1 alpha-Synuclein-binding domain; This coiled-coil domain found in Synphilin-1 is ...
 451-494 6.10e-10

Synphilin-1 alpha-Synuclein-binding domain; This coiled-coil domain found in Synphilin-1 is responsible for binding to alpha-Synuclein.


The actual alignment was detected with superfamily member pfam16700:

Pssm-ID: 435527  Cd Length: 45  Bit Score: 55.13  E-value: 6.10e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1039756377 451 VETCMSLASQVVKLTKQLKEQTVERVTLQSQLQQLLEAQKSEGK 494
Cdd:pfam16700   1 VETCMSLASQVVKLTKQLHEQTAARIAIQKHLQLLFDPQDAEGR 44
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
306-448 1.46e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 72.29  E-value: 1.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756377 306 QGTEERTEYLKKVRSILNIVNEGQISLL-----NGQLECVRWMVsetEAIAEL-SCSKDFPSLIHYAGCYGQEKILLWLL 379
Cdd:COG0666    97 NGDLEIVKLLLEAGADVNARDKDGETPLhlaayNGNLEIVKLLL---EAGADVnAQDNDGNTPLHLAAANGNLEIVKLLL 173

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039756377 380 qfmqEQGISLDEVDREGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERHGHTLCSRYL 448
Cdd:COG0666   174 ----EAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLL 238
SNCAIP_SNCA_bd pfam16700
Synphilin-1 alpha-Synuclein-binding domain; This coiled-coil domain found in Synphilin-1 is ...
 451-494 6.10e-10

Synphilin-1 alpha-Synuclein-binding domain; This coiled-coil domain found in Synphilin-1 is responsible for binding to alpha-Synuclein.


Pssm-ID: 435527  Cd Length: 45  Bit Score: 55.13  E-value: 6.10e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1039756377 451 VETCMSLASQVVKLTKQLKEQTVERVTLQSQLQQLLEAQKSEGK 494
Cdd:pfam16700   1 VETCMSLASQVVKLTKQLHEQTAARIAIQKHLQLLFDPQDAEGR 44
Ank_2 pfam12796
Ankyrin repeats (3 copies);
334-426 6.25e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.97  E-value: 6.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756377 334 NGQLECVRWMVSETEAIAELSCSKDFPslIHYAGCYGQEKILLWLLQFMQeqgisLDEVDrEGNSAVHVASQHGYLGCIQ 413
Cdd:pfam12796   7 NGNLELVKLLLENGADANLQDKNGRTA--LHLAAKNGHLEIVKLLLEHAD-----VNLKD-NGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 1039756377 414 TLVEYGANVTMQN 426
Cdd:pfam12796  79 LLLEKGADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 361-449 2.69e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.57  E-value: 2.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756377 361 SLIHYAGCYGQEKILLWLLQFMQEQGISldevDREGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERHG 440
Cdd:PHA02874  126 TFLHYAIKKGDLESIKMLFEYGADVNIE----DDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYG 201


                  ....*....
gi 1039756377 441 HTLCSRYLV 449
Cdd:PHA02874  202 DYACIKLLI 210
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 395-424 3.60e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.64  E-value: 3.60e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1039756377  395 EGNSAVHVASQHGYLGCIQTLVEYGANVTM 424
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
306-448 1.46e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 72.29  E-value: 1.46e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756377 306 QGTEERTEYLKKVRSILNIVNEGQISLL-----NGQLECVRWMVsetEAIAEL-SCSKDFPSLIHYAGCYGQEKILLWLL 379
Cdd:COG0666    97 NGDLEIVKLLLEAGADVNARDKDGETPLhlaayNGNLEIVKLLL---EAGADVnAQDNDGNTPLHLAAANGNLEIVKLLL 173

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039756377 380 qfmqEQGISLDEVDREGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERHGHTLCSRYL 448
Cdd:COG0666   174 ----EAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLL 238
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
247-449 2.64e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 68.44  E-value: 2.64e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756377 247 AYESENHSKDFLNKVFSDPHSRKIEKSGPDCKLRSFHLQSSAAGAKTEEPINGMNWTNTQGTEERTEYLKKVRSILNIVN 326
Cdd:COG0666     5 LLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756377 327 EGQISLL-----NGQLECVRWMVsetEAIAEL-SCSKDFPSLIHYAGCYGQEKILLWLLqfmqEQGISLDEVDREGNSAV 400
Cdd:COG0666    85 DGGNTLLhaaarNGDLEIVKLLL---EAGADVnARDKDGETPLHLAAYNGNLEIVKLLL----EAGADVNAQDNDGNTPL 157

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1039756377 401 HVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERHGHTLCSRYLV 449
Cdd:COG0666   158 HLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLL 206
SNCAIP_SNCA_bd pfam16700
Synphilin-1 alpha-Synuclein-binding domain; This coiled-coil domain found in Synphilin-1 is ...
 451-494 6.10e-10

Synphilin-1 alpha-Synuclein-binding domain; This coiled-coil domain found in Synphilin-1 is responsible for binding to alpha-Synuclein.


Pssm-ID: 435527  Cd Length: 45  Bit Score: 55.13  E-value: 6.10e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1039756377 451 VETCMSLASQVVKLTKQLKEQTVERVTLQSQLQQLLEAQKSEGK 494
Cdd:pfam16700   1 VETCMSLASQVVKLTKQLHEQTAARIAIQKHLQLLFDPQDAEGR 44
Ank_2 pfam12796
Ankyrin repeats (3 copies);
334-426 6.25e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.97  E-value: 6.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756377 334 NGQLECVRWMVSETEAIAELSCSKDFPslIHYAGCYGQEKILLWLLQFMQeqgisLDEVDrEGNSAVHVASQHGYLGCIQ 413
Cdd:pfam12796   7 NGNLELVKLLLENGADANLQDKNGRTA--LHLAAKNGHLEIVKLLLEHAD-----VNLKD-NGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 1039756377 414 TLVEYGANVTMQN 426
Cdd:pfam12796  79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
363-449 4.95e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 48.57  E-value: 4.95e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756377 363 IHYAGCYGQEKILLWLLqfmqEQGISLDEVDREGNSAVHVASQHGYLGCIQTLVEYgANVTMQNHaGEKPSQSAERHGHT 442
Cdd:pfam12796   1 LHLAAKNGNLELVKLLL----ENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHL 74


                  ....*..
gi 1039756377 443 LCSRYLV 449
Cdd:pfam12796  75 EIVKLLL 81
Ank_4 pfam13637
Ankyrin repeats (many copies);
361-416 1.89e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 45.73  E-value: 1.89e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039756377 361 SLIHYAGCYGQEKILLWLLQFmqeqGISLDEVDREGNSAVHVASQHGYLGCIQTLV 416
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEK----GADINAVDGNGETALHFAASNGNVEVLKLLL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
322-448 1.83e-05

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 47.64  E-value: 1.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756377 322 LNIVNEGQISLL-----NGQLECVRWMVsetEAIAEL-SCSKDFPSLIHYAGCYGQEKILLWLLqfmqEQGISLDEVDRE 395
Cdd:COG0666   146 VNAQDNDGNTPLhlaaaNGNLEIVKLLL---EAGADVnARDNDGETPLHLAAENGHLEIVKLLL----EAGADVNAKDND 218

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1039756377 396 GNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERHGHTLCSRYL 448
Cdd:COG0666   219 GKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
Ank_4 pfam13637
Ankyrin repeats (many copies);
396-449 2.34e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.65  E-value: 2.34e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1039756377 396 GNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERHGHTLCSRYLV 449
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 361-449 2.69e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 44.57  E-value: 2.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039756377 361 SLIHYAGCYGQEKILLWLLQFMQEQGISldevDREGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERHG 440
Cdd:PHA02874  126 TFLHYAIKKGDLESIKMLFEYGADVNIE----DDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYG 201


                  ....*....
gi 1039756377 441 HTLCSRYLV 449
Cdd:PHA02874  202 DYACIKLLI 210
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 384-440 3.35e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.04  E-value: 3.35e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039756377 384 EQGISLDEVDREGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERHG 440
Cdd:PTZ00322  103 TGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENG 159
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 395-424 3.60e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.64  E-value: 3.60e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1039756377  395 EGNSAVHVASQHGYLGCIQTLVEYGANVTM 424
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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