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Conserved domains on  [gi|1039796821|ref|XP_017173937|]
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G2/mitotic-specific cyclin-B3 isoform X1 [Mus musculus]

Protein Classification

cyclin family protein( domain architecture ID 1750054)

cyclin family protein may associate with and activate its cognate cyclin-dependent kinase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_SF super family cl40454
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 1123-1261 4.02e-66

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


The actual alignment was detected with superfamily member cd20508:

Pssm-ID: 477360 [Multi-domain]  Cd Length: 142  Bit Score: 219.82  E-value: 4.02e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1123 EKEGQDPLLNTIYAKDVFNYLKEREEKFLVQKYMDGQMELTSDMRAILVDWLVEIQGSFQMTHETLYLAVKIMDLYLMKA 1202
Cdd:cd20508      4 EENSDDPFQVSEYAKDIFDYMKEREEKFVVPDYLEKQTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLYLSKK 83

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039796821 1203 QCKKNHLQLLGSTTYMIAAKFEESYPPSLSEFLFICEDMYEKSDMVSLESSILQTLNFD 1261
Cdd:cd20508     84 VVKKEKLQLLGATAILIASKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLDFD 142
CYCLIN_SF super family cl40454
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 1265-1379 1.92e-51

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


The actual alignment was detected with superfamily member cd20510:

Pssm-ID: 477360  Cd Length: 115  Bit Score: 176.70  E-value: 1.92e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1265 PTAYNFLRRYASCIHASMKTLTLSRFICEMTLQEYEYIEERPSKLAAASFILALYMRNLSNCVPTLEYFTGYKMAELHIL 1344
Cdd:cd20510      1 PLSYRFLRRYAKCARASMETLTLARYILELSLMEYQFVQERASKLAAAALLLALKMKNLGEWTPTLEYYSGYSAEDLLPL 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1039796821 1345 VRKLNHLLNFRSHSILKNVFEKYSEETYFEVAKIP 1379
Cdd:cd20510     81 VRKLNAMLTKPPNKKLKTVRSKYSHKVFFEVAKIP 115
 
Name Accession Description Interval E-value
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 1123-1261 4.02e-66

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 219.82  E-value: 4.02e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1123 EKEGQDPLLNTIYAKDVFNYLKEREEKFLVQKYMDGQMELTSDMRAILVDWLVEIQGSFQMTHETLYLAVKIMDLYLMKA 1202
Cdd:cd20508      4 EENSDDPFQVSEYAKDIFDYMKEREEKFVVPDYLEKQTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLYLSKK 83

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039796821 1203 QCKKNHLQLLGSTTYMIAAKFEESYPPSLSEFLFICEDMYEKSDMVSLESSILQTLNFD 1261
Cdd:cd20508     84 VVKKEKLQLLGATAILIASKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLDFD 142
CYCLIN_CCNB3_rpt2 cd20510
second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 ...
 1265-1379 1.92e-51

second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410214  Cd Length: 115  Bit Score: 176.70  E-value: 1.92e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1265 PTAYNFLRRYASCIHASMKTLTLSRFICEMTLQEYEYIEERPSKLAAASFILALYMRNLSNCVPTLEYFTGYKMAELHIL 1344
Cdd:cd20510      1 PLSYRFLRRYAKCARASMETLTLARYILELSLMEYQFVQERASKLAAAALLLALKMKNLGEWTPTLEYYSGYSAEDLLPL 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1039796821 1345 VRKLNHLLNFRSHSILKNVFEKYSEETYFEVAKIP 1379
Cdd:cd20510     81 VRKLNAMLTKPPNKKLKTVRSKYSHKVFFEVAKIP 115
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 1138-1263 2.29e-42

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 151.13  E-value: 2.29e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1138 DVFNYLKEREEKFLVQK-YMDGQMELTSDMRAILVDWLVEIQGSFQMTHETLYLAVKIMDLYLMKAQCKKNHLQLLGSTT 1216
Cdd:pfam00134    1 DIFQYLRELELKYLPKPdYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1039796821 1217 YMIAAKFEESYPPSLSEFLFICEDMYEKSDMVSLESSILQTLNFDIN 1263
Cdd:pfam00134   81 LFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
1054-1372 6.26e-42

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 160.33  E-value: 6.26e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1054 ENKNSPNMSSNAFESRTDNSSAIMPSS-----KAFNPVENSNPYVSSSKsfkstlgAKETEITIQDDSDSLERIEKEGQ- 1127
Cdd:COG5024    100 PRLSECNLDSILFIQMTLNEDSYEPMIdyilkKDENSLSPYELDENQLA-------LDEKQAESKRESQSWQDLDATDQe 172

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1128 DPLLNTIYAKDVFNYLKEREEKFLVQK-YMDGQMELTSDMRAILVDWLVEIQGSFQMTHETLYLAVKIMDLYLMKAQCKK 1206
Cdd:COG5024    173 DPLMVPEYASDIFEYLLKLELIDLPNPnYLIKQSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSL 252

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1207 NHLQLLGSTTYMIAAKFEESYPPSLSEFLFICEDMYEKSDMVSLESSILQTLNFDINIPTAYNFLRRYASCIHASMKTLT 1286
Cdd:COG5024    253 EKYQLVGISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKASDYDIFSRT 332

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1287 LSRFICEMTLQEYEYIEERPSKLAAASFILALYMRNLSNCVPTLEYFTG-YKMAELHILVRKLNHLLNFRSHSIlKNVFE 1365
Cdd:COG5024    333 PAKFSSEISPVDYKFIQISPSWCAAAAMYLSRKILSQNQWDRTLIHYSGnYTNPDLKPLNESNKENLQNPSVHH-DAIFP 411


                   ....*..
gi 1039796821 1366 KYSEETY 1372
Cdd:COG5024    412 KYPSPTF 418
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 1265-1381 2.93e-32

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 121.96  E-value: 2.93e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1265 PTAYNFLRRYASCIHAS--MKTLTLSRFICEMTLQEYEYIEERPSKLAAASFILALYMRNLSNCVPTLEYFTGYKMAELH 1342
Cdd:pfam02984    1 PTPLSFLRRFSKAADYLhdLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNSPEWTETLEHYTGYSEEDLK 80

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1039796821 1343 ILVRKLNHLLNFRSHSILKNVFEKYSEETYFEVAKIPPL 1381
Cdd:pfam02984   81 PCVKLLLELLLNAPSSKLQAVRRKYSSSKFMKVSTLPPL 119
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 1172-1256 3.80e-12

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 63.38  E-value: 3.80e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821  1172 DWLVEIQGSFQMTHETLYLAVKIMDLYLMKAQCKKNHLQLLGSTTYMIAAKFEESYPPSLSEFLFICEdmYEKSDMVSLE 1251
Cdd:smart00385    1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRME 78


                    ....*
gi 1039796821  1252 SSILQ 1256
Cdd:smart00385   79 RLLLE 83
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 1269-1353 2.04e-09

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 55.68  E-value: 2.04e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821  1269 NFLRRYASCIHASMKTLTLSRFICEMTLQEYEYIEERPSKLAAASFILALYMRNLSNCVPTLEYFTGYKmaELHILVRKL 1348
Cdd:smart00385    1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYF--TEEEILRME 78


                    ....*
gi 1039796821  1349 NHLLN 1353
Cdd:smart00385   79 RLLLE 83
 
Name Accession Description Interval E-value
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 1123-1261 4.02e-66

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 219.82  E-value: 4.02e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1123 EKEGQDPLLNTIYAKDVFNYLKEREEKFLVQKYMDGQMELTSDMRAILVDWLVEIQGSFQMTHETLYLAVKIMDLYLMKA 1202
Cdd:cd20508      4 EENSDDPFQVSEYAKDIFDYMKEREEKFVVPDYLEKQTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLYLSKK 83

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039796821 1203 QCKKNHLQLLGSTTYMIAAKFEESYPPSLSEFLFICEDMYEKSDMVSLESSILQTLNFD 1261
Cdd:cd20508     84 VVKKEKLQLLGATAILIASKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLDFD 142
CYCLIN_CCNB3_rpt2 cd20510
second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 ...
 1265-1379 1.92e-51

second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410214  Cd Length: 115  Bit Score: 176.70  E-value: 1.92e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1265 PTAYNFLRRYASCIHASMKTLTLSRFICEMTLQEYEYIEERPSKLAAASFILALYMRNLSNCVPTLEYFTGYKMAELHIL 1344
Cdd:cd20510      1 PLSYRFLRRYAKCARASMETLTLARYILELSLMEYQFVQERASKLAAAALLLALKMKNLGEWTPTLEYYSGYSAEDLLPL 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1039796821 1345 VRKLNHLLNFRSHSILKNVFEKYSEETYFEVAKIP 1379
Cdd:cd20510     81 VRKLNAMLTKPPNKKLKTVRSKYSHKVFFEVAKIP 115
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 1135-1260 2.52e-47

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 165.40  E-value: 2.52e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1135 YAKDVFNYLKEREEKFLVQK-YMDGQMELTSDMRAILVDWLVEIQGSFQMTHETLYLAVKIMDLYLMKAQCKKNHLQLLG 1213
Cdd:cd20507      4 YVKDIYKYLRQLEKKYAIDPdYLSGQPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKKLQLVG 83

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1039796821 1214 STTYMIAAKFEESYPPSLSEFLFICEDMYEKSDMVSLESSILQTLNF 1260
Cdd:cd20507     84 VTALLIASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLDF 130
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 1138-1263 2.29e-42

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 151.13  E-value: 2.29e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1138 DVFNYLKEREEKFLVQK-YMDGQMELTSDMRAILVDWLVEIQGSFQMTHETLYLAVKIMDLYLMKAQCKKNHLQLLGSTT 1216
Cdd:pfam00134    1 DIFQYLRELELKYLPKPdYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTC 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1039796821 1217 YMIAAKFEESYPPSLSEFLFICEDMYEKSDMVSLESSILQTLNFDIN 1263
Cdd:pfam00134   81 LFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
1054-1372 6.26e-42

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 160.33  E-value: 6.26e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1054 ENKNSPNMSSNAFESRTDNSSAIMPSS-----KAFNPVENSNPYVSSSKsfkstlgAKETEITIQDDSDSLERIEKEGQ- 1127
Cdd:COG5024    100 PRLSECNLDSILFIQMTLNEDSYEPMIdyilkKDENSLSPYELDENQLA-------LDEKQAESKRESQSWQDLDATDQe 172

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1128 DPLLNTIYAKDVFNYLKEREEKFLVQK-YMDGQMELTSDMRAILVDWLVEIQGSFQMTHETLYLAVKIMDLYLMKAQCKK 1206
Cdd:COG5024    173 DPLMVPEYASDIFEYLLKLELIDLPNPnYLIKQSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSL 252

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1207 NHLQLLGSTTYMIAAKFEESYPPSLSEFLFICEDMYEKSDMVSLESSILQTLNFDINIPTAYNFLRRYASCIHASMKTLT 1286
Cdd:COG5024    253 EKYQLVGISALFIASKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKASDYDIFSRT 332

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1287 LSRFICEMTLQEYEYIEERPSKLAAASFILALYMRNLSNCVPTLEYFTG-YKMAELHILVRKLNHLLNFRSHSIlKNVFE 1365
Cdd:COG5024    333 PAKFSSEISPVDYKFIQISPSWCAAAAMYLSRKILSQNQWDRTLIHYSGnYTNPDLKPLNESNKENLQNPSVHH-DAIFP 411


                   ....*..
gi 1039796821 1366 KYSEETY 1372
Cdd:COG5024    412 KYPSPTF 418
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 1135-1260 4.04e-37

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 136.22  E-value: 4.04e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1135 YAKDVFNYLKEREEKFLVQ-KYMDGQMELTSDMRAILVDWLVEIQGSFQMTHETLYLAVKIMDLYLMKAQCKKNHLQLLG 1213
Cdd:cd20504      2 YADDIYEYLRESELKHRPKpDYMRKQPDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSKLQLVG 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1039796821 1214 STTYMIAAKFEESYPPSLSEFLFICEDMYEKSDMVSLESSILQTLNF 1260
Cdd:cd20504     82 TACMFIAAKYEEIYPPEVEEFVYITDDTYTKKQVLRMEHLVLKVLSF 128
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 1128-1260 8.69e-37

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 135.50  E-value: 8.69e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1128 DPLLNTIYAKDVFNYLKEREEKFL-VQKYMDGQMELTSDMRAILVDWLVEIQGSFQMTHETLYLAVKIMDLYLMKAQCKK 1206
Cdd:cd20568      1 DPLMVAEYVPEIFEYLRELELKTLpNPNYMDDQKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRVVSL 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039796821 1207 NHLQLLGSTTYMIAAKFEESYPPSLSEFLFICEDMYEKSDMVSLESSILQTLNF 1260
Cdd:cd20568     81 NKLQLVGISALFIASKYEEVNSPSIKNFAYMTDGAYTVEDILRAERYMLNTLEF 134
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 1135-1261 1.42e-32

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 123.24  E-value: 1.42e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1135 YAKDVFNYLKEREEKFLVQK-YMDGQMELTSDMRAILVDWLVEIQGSFQMTHETLYLAVKIMDLYLMKAQCKKNHLQLLG 1213
Cdd:cd20561      4 YHEDIHTYLREMEVKCKPKVgYMKKQPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVG 83

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1039796821 1214 STTYMIAAKFEESYPPSLSEFLFICEDMYEKSDMVSLESSILQTLNFD 1261
Cdd:cd20561     84 TAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRMEHLVLKVLTFD 131
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 1265-1381 2.93e-32

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 121.96  E-value: 2.93e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1265 PTAYNFLRRYASCIHAS--MKTLTLSRFICEMTLQEYEYIEERPSKLAAASFILALYMRNLSNCVPTLEYFTGYKMAELH 1342
Cdd:pfam02984    1 PTPLSFLRRFSKAADYLhdLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLARKTLNSPEWTETLEHYTGYSEEDLK 80

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1039796821 1343 ILVRKLNHLLNFRSHSILKNVFEKYSEETYFEVAKIPPL 1381
Cdd:pfam02984   81 PCVKLLLELLLNAPSSKLQAVRRKYSSSKFMKVSTLPPL 119
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 1135-1260 7.16e-32

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 121.14  E-value: 7.16e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1135 YAKDVFNYLKEREEKFLV-QKYMDGQmELTSDMRAILVDWLVEIQGSFQMTHETLYLAVKIMDLYLMKAQCKKNHLQLLG 1213
Cdd:cd20565      4 YVKDIYAYLRQLEEEQAVrPKYLEGQ-EVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKMLQLVG 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1039796821 1214 STTYMIAAKFEESYPPSLSEFLFICEDMYEKSDMVSLESSILQTLNF 1260
Cdd:cd20565     83 VTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALDF 129
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 1128-1260 1.33e-30

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 118.22  E-value: 1.33e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1128 DPLLNTIYAKDVFNYLKEREEKFLVQ-KYMDGQMELTSDMRAILVDWLVEIQGSFQMTHETLYLAVKIMDLYLMKAQCKK 1206
Cdd:cd20567     14 NPLAAVEYVEDIYSFYRKVEPESCVPpYYMSQQPDINEKMRAILIDWLIEVHLKFELMPETLYLTVNLIDRFLSVKQVPR 93

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039796821 1207 NHLQLLGSTTYMIAAKFEESYPPSLSEFLFICEDMYEKSDMVSLESSILQTLNF 1260
Cdd:cd20567     94 KELQLVGVTAMLIASKYEEIWAPEVNDFVYISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 1128-1260 1.63e-30

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 117.66  E-value: 1.63e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1128 DPLLNTIYAKDVFNYLKERE-EKFLVQKYMDGQmELTSDMRAILVDWLVEIQGSFQMTHETLYLAVKIMDLYLMKAQCKK 1206
Cdd:cd20566      1 NPQLCSDYVKDIYQYLRQLEvQQSIRPHYLDGK-EINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVSR 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039796821 1207 NHLQLLGSTTYMIAAKFEESYPPSLSEFLFICEDMYEKSDMVSLESSILQTLNF 1260
Cdd:cd20566     80 KKLQLVGVTALLLASKYEEMYSPEIGDFVYITDNAYTKAQIREMEMLILKELNF 133
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 1128-1261 1.03e-29

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 115.20  E-value: 1.03e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1128 DPLLNTIYAKDVFNYLKEREEKFL-VQKYMDG-QMELTSDMRAILVDWLVEIQGSFQMTHETLYLAVKIMDLYLMKAQCK 1205
Cdd:cd20562      1 DPQMCSLYATDIYLNLRVAELKRRpLPDYMEKiQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVN 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039796821 1206 KNHLQLLGSTTYMIAAKFEESYPPSLSEFLFICEDMYEKSDMVSLESSILQTLNFD 1261
Cdd:cd20562     81 RQRLQLLGVSCMLIASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQFE 136
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 1120-1261 1.07e-29

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 116.09  E-value: 1.07e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1120 ERIEKEGQDPLLNTIYAKDVFNYLKEREEKFLVQK-YMDGQMELTSDMRAILVDWLVEIQGSFQMTHETLYLAVKIMDLY 1198
Cdd:cd20560     21 EDDSAADVDVLAVPEYAEDIHQYLREAELKHRPKPgYMRKQPDITTGMRTILVDWLVEVGEEYKLQTETLYLAVNYLDRF 100

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039796821 1199 LMKAQCKKNHLQLLGSTTYMIAAKFEESYPPSLSEFLFICEDMYEKSDMVSLESSILQTLNFD 1261
Cdd:cd20560    101 LSCMSVLRGKLQLVGTAAILLASKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKVLAFD 163
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 1137-1260 3.54e-25

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 102.01  E-value: 3.54e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1137 KDVFNYLKEREEKFLVQKYMDGQM-ELTSDMRAILVDWLVEIQGSFQMTHETLYLAVKIMDLYL-MKAQCKKNHLQLLGS 1214
Cdd:cd20519      6 EEVWDLMLKKEELYKRDRDFLNRHpSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLsTQTNVPKTQLQLIGI 85

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1039796821 1215 TTYMIAAKFEESYPPSLSEFLFICEDMYEKSDMVSLESSILQTLNF 1260
Cdd:cd20519     86 TCLFIAAKLEEIYPPKLSEFAYVTDGACTEDEILTMELIILKALNW 131
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 1166-1258 1.41e-24

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 98.94  E-value: 1.41e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1166 MRAILVDWLVEIQGSFQMTHETLYLAVKIMDLYLMKAQCKKNHLQLLGSTTYMIAAKFEESYPPSLSEFLFICEDMYEKS 1245
Cdd:cd20536      1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTRE 80

                           90
                   ....*....|...
gi 1039796821 1246 DMVSLESSILQTL 1258
Cdd:cd20536     81 QICNLECIILTKL 93
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 1167-1262 2.31e-23

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 95.85  E-value: 2.31e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1167 RAILVDWLVEIQGSFQMTHETLYLAVKIMDLYLMKAQCKKNHLQLLGSTTYMIAAKFEESYPPSLSEFLFICEDMYEKSD 1246
Cdd:cd20542      1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKKQ 80

                           90
                   ....*....|....*.
gi 1039796821 1247 MVSLESSILQTLNFDI 1262
Cdd:cd20542     81 VLRMERRVLRRLRFDL 96
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 1265-1372 1.61e-19

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 85.38  E-value: 1.61e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1265 PTAYNFLRRY---ASCIHASMKTLTLSRFICEMTLQEYEYIEERPSKLAAASFILALYMRNLSNCVPTLEYFTGYKMAEL 1341
Cdd:cd20506      1 PTIKTFLRRFlraAQASVPDLKLEFLANYLAELSLLDYEFLKYLPSLIAASAVFLARHTLNPHPWNPTLEHYTGYKAADL 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1039796821 1342 HILVRKLNHLLNFRSHSILKNVFEKYSEETY 1372
Cdd:cd20506     81 KPCVQALHDLQLNASGSSLQAVREKYKQHKF 111
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 1129-1260 4.25e-19

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 84.93  E-value: 4.25e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1129 PLLNTIYAKDVFNYLKEREEKFLVQK-YMDGQMELTSDMRAILVDWLVEIQGSFQMTHETLYLAVKIMDLYLMKAQ-CKK 1206
Cdd:cd20579      4 PVLGWANRDEVWKNMLNKDKTYLRDKnFLQKHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQEnVVK 83

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039796821 1207 NHLQLLGSTTYMIAAKFEESYPPSLSEFLFICEDMYEKSDMVSLESSILQTLNF 1260
Cdd:cd20579     84 TRLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALKW 137
CYCLIN_CCNB1-like_rpt2 cd20509
second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 1265-1375 7.96e-19

second cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410213  Cd Length: 111  Bit Score: 83.43  E-value: 7.96e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1265 PTAYNFLRRYASCIHASMKTLTLSRFICEMTLQEYEYIEERPSKLAAASFILALYMRNLSNCVPTLEYFTGYKMAELHIL 1344
Cdd:cd20509      1 PLPLHFLRRFSKAGGADAQKHTLAKYLMELTLLDYDMVHYKPSEIAAAALCLSRKILDEPEWTPTLEHYSTYSEEDLLPI 80

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1039796821 1345 VRKLNHLLNFRSHSILKNVFEKYSEETYFEV 1375
Cdd:cd20509     81 VQKMAKLVVKSQTSKYQAVKNKYSSSKFMRI 111
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 1265-1341 7.38e-18

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 79.66  E-value: 7.38e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039796821 1265 PTAYNFLRRYASCIHASMKTLTLSRFICEMTLQEYEYIEERPSKLAAASFILALYMRNLSNCVP-TLEYFTGYKMAEL 1341
Cdd:cd20537      1 PTPLSFLRRYLSLLGLDEKVRHLARYLLELSLLDYEFLKYRPSLIAAAALYLARKILGEPPPSPqLLQLVTGYSENDL 78
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 1129-1260 7.80e-18

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 81.43  E-value: 7.80e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1129 PLLNTIYAKDVFNYLKEREEKFLVQKYMDGQM-ELTSDMRAILVDWLVEIQGSFQMTHETLYLAVKIMDLYLM-KAQCKK 1206
Cdd:cd20580      4 PELSWGNSKDVWLNMLKKESKYVHDKHFLQLHpALQPKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLtQKNINK 83

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039796821 1207 NHLQLLGSTTYMIAAKFEESYPPSLSEFLFICEDMYEKSDMVSLESSILQTLNF 1260
Cdd:cd20580     84 SMLQLIGITSLFIASKLEEIYPPKLHEFAYVTDGACSEDDILDMELIILKALKW 137
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 1170-1261 2.92e-15

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 72.42  E-value: 2.92e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1170 LVDWLVEIQGSFQMTHETLYLAVKIMDLYLMKAQCKKNHLQLLGSTTYMIAAKFEESYP--PSLSEFLFICEDMYEKSDM 1247
Cdd:cd20559      2 LLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESKArvPLLSELSKMCCNSYGEELF 81

                           90
                   ....*....|....
gi 1039796821 1248 VSLESSILQTLNFD 1261
Cdd:cd20559     82 IQMEMHILNTLNWD 95
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 1166-1260 1.74e-13

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 67.63  E-value: 1.74e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1166 MRAILVDWLVEIQGSFQMTHETLYLAVKIMDLYLMKAQCKKNHLQLLGSTTYMIAAKFEESYP--PSLSEFL-FICEDMY 1242
Cdd:cd20528      6 LRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEELDDniPKISDLNrYLCNSVY 85

                           90
                   ....*....|....*...
gi 1039796821 1243 EKSDMVSLESSILQTLNF 1260
Cdd:cd20528     86 SKQEYLQMELLILEFFQW 103
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 1166-1258 2.42e-13

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 66.96  E-value: 2.42e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1166 MRAILVDWLVEIQGSFQMTHETLYLAVKIMDLYLMKAQCKKNHLQLLGSTTYMIAAKFEESYPPSLSEFLFICEDMYEKS 1245
Cdd:cd20521      3 MRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTDNTYKYE 82

                           90
                   ....*....|...
gi 1039796821 1246 DMVSLESSILQTL 1258
Cdd:cd20521     83 DVVRMMGEIVAAL 95
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 1265-1380 2.88e-12

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410215  Cd Length: 117  Bit Score: 64.63  E-value: 2.88e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1265 PTAYNFLRRYASCIHASMKTLTLSRFICEMTLQEYEYIEERPSKLAAASFILAlyMRNLSNC---VPTLEYFTGYKMAEL 1341
Cdd:cd20511      1 PTPYVFLVRFLKAAQSDKKLENLAFFLVELGLVEYEMLKYSPSMLAASAVYTA--RCTLNKTpewTSTLEFHTGYSESQL 78

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1039796821 1342 HILVRKLNHLLNFRSHSILKNVFEKYSEETYFEVAKIPP 1380
Cdd:cd20511     79 MECARLMVRLHSKAGTGKLTAVYKKYSSSKFGAVALLPP 117
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 1172-1256 3.80e-12

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 63.38  E-value: 3.80e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821  1172 DWLVEIQGSFQMTHETLYLAVKIMDLYLMKAQCKKNHLQLLGSTTYMIAAKFEESYPPSLSEFLFICEdmYEKSDMVSLE 1251
Cdd:smart00385    1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRME 78


                    ....*
gi 1039796821  1252 SSILQ 1256
Cdd:smart00385   79 RLLLE 83
CYCLIN_CCNA_rpt2 cd20505
second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 1265-1372 9.39e-12

second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410209 [Multi-domain]  Cd Length: 110  Bit Score: 63.08  E-value: 9.39e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1265 PTAYNFLRRYASCIHASMKTLTLSRFICEMTLQEYE-YIEERPSKLAAASFILALYmrNLSNCV--PTLEYFTGYKMAEL 1341
Cdd:cd20505      1 PTSNWFLERFLKHSNADEKTKSLAMYLCELSLIDADpYLKYLPSVIAAAAVCLANH--TLGNEVwpQKLARSTGYSLEDL 78

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1039796821 1342 HILVRKLNHLLNFRSHSILKNVFEKYSEETY 1372
Cdd:cd20505     79 LPCLRDLHRTFLNAPSSPQQAIREKYKSSKY 109
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 1162-1258 1.08e-10

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 59.88  E-value: 1.08e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1162 LTSDMRAILVDWLVEIQGSFQMTHETLYLAVKIMDLYLMKAQCKKNHLQLLGSTTYMIAAKFEESYPPSLSEFLFICEDM 1241
Cdd:cd20517      1 VTSDNRKILLTWMFLVCESFELDKNVFPLAVSLLDRLLLKKQGTKETLQKTGAACLLIASKIRTVKPITVSKLTYLSCDC 80

                           90
                   ....*....|....*..
gi 1039796821 1242 YEKSDMVSLESSILQTL 1258
Cdd:cd20517     81 FTNLELINQEKDILEAL 97
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 1121-1261 2.83e-10

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 60.00  E-value: 2.83e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1121 RIEKEGQDPLLntIYAKDVFNYLKEREEKFL--VQKYMDGQMELTSDMRAILVDWLVEIQGSFQMTHETLYLAVKIMDLY 1198
Cdd:cd20575     10 RVPRAGPDPRL--LGDQRVLQNLLRLEERYVprVSYFQCVQREIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRY 87

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039796821 1199 LMKAQCKKNHLQLLGSTTYMIAAKFEESYPPSLSEFLFICEDMYEKSDMVSLESSILQTLNFD 1261
Cdd:cd20575     88 LSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDNSISPRQLLDWEILVLGKLKWD 150
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 1170-1238 7.98e-10

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 56.65  E-value: 7.98e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039796821 1170 LVDWLVEIQGSFQMTHETLYLAVKIMDLYLMKAQCKKNHLQLLGSTTYMIAAKFEEsYPPSLSEFLFIC 1238
Cdd:cd00043      2 AVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEE-LPRTLKEIAKVS 69
CYCLIN_CCNA1_rpt2 cd20563
second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily ...
 1265-1380 1.68e-09

second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410266  Cd Length: 123  Bit Score: 57.13  E-value: 1.68e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1265 PTAYNFLRRYASCIHASMKTLTLSRFICEMTLQEYE-YIEERPSKLAAASFILALYMRNLSNCVPTLEYFTGYKMAELHI 1343
Cdd:cd20563      1 PTINQFLLQYLKRHEVCEKTENLAMYVAELSLLEVDpFLKYLPSLTAAAAYCLANYTVNKVFWPETLAAFTGYSLSEIVP 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1039796821 1344 LVRKLNHLLNFRSHSILKNVFEKYSEETYFEVAKIPP 1380
Cdd:cd20563     81 CLSDLHKACLGAPHRPQQAIREKYKGSKYMQVSLLEP 117
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 1269-1353 2.04e-09

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 55.68  E-value: 2.04e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821  1269 NFLRRYASCIHASMKTLTLSRFICEMTLQEYEYIEERPSKLAAASFILALYMRNLSNCVPTLEYFTGYKmaELHILVRKL 1348
Cdd:smart00385    1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGYF--TEEEILRME 78


                    ....*
gi 1039796821  1349 NHLLN 1353
Cdd:smart00385   79 RLLLE 83
CYCLIN_CCNB1_rpt2 cd20569
second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 ...
 1265-1381 7.07e-09

second cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1) and similar proteins; CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410272  Cd Length: 121  Bit Score: 55.28  E-value: 7.07e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1265 PTAYNFLRRYASCIHASMKTLTLSRFICEMTLQEYEYIEERPSKLAAASFILALYMRNLSNCVPTLEYFTGYKMAEL--- 1341
Cdd:cd20569      1 PLPLHFLRRASKIGEVDVEQHTLAKYLMELTMVDYDMVHFPPSQIAAAAFCLALKILDNGEWTPTLQHYMSYTEESLlpv 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1039796821 1342 --HIL--VRKLNHLLNfrSHSILKNvfeKYSEETYFEVAKIPPL 1381
Cdd:cd20569     81 mqHMAknVVKVNQGLT--KHMTVKN---KYASSKQMKISTLPQL 119
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 1159-1261 7.41e-08

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 53.06  E-value: 7.41e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1159 QMELTSDMRAILVDWLVEIQGSFQMTHETLYLAVKIMDLYLMKAQCKKNHLQLLGSTTYMIAAKFEESYPPSLSEFLFIC 1238
Cdd:cd20573     47 QKEILPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKSRLQLLGATCMFLASKMKETIPLTAEKLCIYT 126

                           90       100
                   ....*....|....*....|...
gi 1039796821 1239 EDMYEKSDMVSLESSILQTLNFD 1261
Cdd:cd20573    127 DNSIRPEELLQMELLVLNKLKWD 149
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 1167-1259 9.50e-08

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 51.16  E-value: 9.50e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1167 RAILVDWLVEIQGSFQMTHETLYLAVKIMDLYL--MKAQCKKNH-LQLLGSTTYMIAAKFEESYPPSLSEF-----LFIC 1238
Cdd:cd20543      2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLssYDLPKDKPWmLQLLAVACLSLAAKMEETDVPLLVDLqveepKYVF 81

                           90       100
                   ....*....|....*....|.
gi 1039796821 1239 EdmyEKSDMVsLESSILQTLN 1259
Cdd:cd20543     82 E---AKTIQR-MELLVLSTLE 98
CYCLIN_SDS-like_rpt2 cd20721
second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, ...
 1265-1323 1.12e-07

second cyclin box found in Arabidopsis thaliana cyclin-SDS and similar proteins; Cyclin-SDS, also called protein SOLO DANCERS, is a meiosis-specific cyclin that is required for normal homolog synapsis and recombination in early to mid-prophase 1. It contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410310  Cd Length: 104  Bit Score: 51.36  E-value: 1.12e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039796821 1265 PTAYNFLRRYASCI-------HASMKTLTLSRFICEMTLQEYEYIEERPSKLAAASFILALYMRNL 1323
Cdd:cd20721      1 PTILTFLRMYIERLslesgaaHASRPLERLAMFLAEISLLHYSFLQFRPSTVAAACLVLAEIMHNR 66
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 1139-1228 2.63e-07

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 51.53  E-value: 2.63e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1139 VFNYLKEREEKFLVQ-KYMDG-QMELTSDMRAILVDWLVEIQGSFQMTHETLYLAVKIMDLYLMKAQCKKNHLQLLGSTT 1216
Cdd:cd20515     26 VLQNLLSLEERYLPSaSYFKCvQTEIQPFMRKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRFLSLVPIRKSQLQLLGAVC 105

                           90
                   ....*....|..
gi 1039796821 1217 YMIAAKFEESYP 1228
Cdd:cd20515    106 LFLASKLKETIP 117
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 1128-1261 4.21e-07

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 51.15  E-value: 4.21e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1128 DPllNTIYAKDVFNYLKEREEKFLVQ-KYMDG-QMELTSDMRAILVDWLVEIQGSFQMTHETLYLAVKIMDLYLMKAQCK 1205
Cdd:cd20574     17 DP--NLLYDDRVLQNLLTIEERYLPQcSYFKCvQKDIQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAVVPTR 94

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039796821 1206 KNHLQLLGSTTYMIAAKFEESYPPSLSEFLFICEDMYEKSDMVSLESSILQTLNFD 1261
Cdd:cd20574     95 KCHLQLLGAVCMFLASKLKETIPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKWN 150
CYCLIN_CLBs_yeast_rpt2 cd20512
second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae ...
 1268-1376 4.27e-07

second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410216  Cd Length: 116  Bit Score: 49.92  E-value: 4.27e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1268 YNFLRRYASCIHASMKTLTLSRFICEMTLQEYEYIEERPSKLAAASFILALYMRNLSNCVPTLEYFTGYKMAELHILVRK 1347
Cdd:cd20512      3 MNFLRRISKADDYDIQTRTLAKYLLEITILDHRFLGYPPSLLAAAAMYLARKMLGRGDWNDNLVHYSGYTESQLIPCADI 82

                           90       100
                   ....*....|....*....|....*....
gi 1039796821 1348 LNHLLNfRSHSILKNVFEKYSEETYFEVA 1376
Cdd:cd20512     83 MLEYLV-KPIKHHDAFFKKYSSKKFLKAS 110
CYCLIN_CCNB2_rpt2 cd20570
second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 ...
 1265-1381 2.73e-06

second cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410273  Cd Length: 119  Bit Score: 47.95  E-value: 2.73e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1265 PTAYNFLRRYASCIHASMKTLTLSRFICEMTLQEYEYIEERPSKLAAASFILALYMRNLSNCVPTLEYFTGYKMAELHIL 1344
Cdd:cd20570      1 PLPLHFLRRASKAGSADVEKHTLAKYLMELTLIDYDMVHYHPSEIAAAALCLSQKVLDGGKWSLTQQYYTGYTEDDLKPI 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1039796821 1345 -------VRKLNHllNFRSHSILKNvfeKYSEETYFEVAKIPPL 1381
Cdd:cd20570     81 mqhmaknVVKVNE--GLTKHVAVKN---KYASSKLMKISTIPQL 119
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 1265-1348 1.53e-05

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 45.05  E-value: 1.53e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1265 PTAYNFLRRYASC------------IHASMKTLTL----SRFICEMTLQEYEYIEERPSKLAAASFILALYMRNLSNCVP 1328
Cdd:cd20529      1 PTPAHFLEYYLSQgvlfvddhdglpSELLEKVKEYvrkyADFFLDLSLQDYAFLNYKPSLLAAACIAAARKALGLSPTWP 80

                           90       100
                   ....*....|....*....|.
gi 1039796821 1329 T-LEYFTGYKMAELHILVRKL 1348
Cdd:cd20529     81 EeLEKLTGYSEDELEPCVELL 101
CYCLIN_CCNO_rpt2 cd20722
second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of ...
 1265-1351 3.25e-05

second cyclin box found in cyclin-O (CCNO); CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410311  Cd Length: 97  Bit Score: 43.87  E-value: 3.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1265 PTAYNFLRRYAS---------CIHASMKTLTLSRFICEMTLQEYEYIEERPSKLAAASFILALYMRNLSNcvPTLEYFTG 1335
Cdd:cd20722      1 PTLQFFLEHFSSlrlenrelsCAEEARKARALARYLAELSLADYAFNQYPPSLLAICSLELADRMLQHRS--PITERLSG 78

                           90
                   ....*....|....*.
gi 1039796821 1336 YKMAELHILVRKLNHL 1351
Cdd:cd20722     79 YPQSALEDCVGKLRLL 94
CYCLIN_CCNA2_rpt2 cd20564
second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1 ...
 1265-1372 5.79e-05

second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly overexpressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410267  Cd Length: 110  Bit Score: 43.66  E-value: 5.79e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1265 PTAYNFLRRYASCIHASMKTLTLSRFICEMTLQEYE-YIEERPSKLAAASFILALYMRNLSNCVPTLEYFTGYKMAELHI 1343
Cdd:cd20564      1 PTINQFLTQYFLHQQANCKVESLSMFLGELSLIDADpYLKYLPSVIAAAAFHLALYTVTGQSWPESLVQKTGYTLESLKP 80

                           90       100
                   ....*....|....*....|....*....
gi 1039796821 1344 LVRKLNHLLNFRSHSILKNVFEKYSEETY 1372
Cdd:cd20564     81 CLMDLHQTYLKAPQHAQQSIREKYKNSKY 109
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 1171-1262 2.06e-04

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 41.91  E-value: 2.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1171 VDWLVEIQGSFQMTHETLYLAVKIMD--LYLMKAQCKknHLQLLGSTTYMIAAKF--EESYPPSLSEFLFICEDMYEKSD 1246
Cdd:cd20526      6 VRWLAELNSQFKFYPETFALAVSILDrfLASVKARPK--YLRCIAISCLFLAAKTneEDEVIPSTKDLVRVSKCGCSVAE 83

                           90
                   ....*....|....*.
gi 1039796821 1247 MVSLESSILQTLNFDI 1262
Cdd:cd20526     84 VLRMERIILDKLHWDL 99
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
 1181-1258 4.32e-04

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 40.80  E-value: 4.32e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1181 FQMTHETLYLAVKIMDLYLMKAQCKKNHLQLLGSTTYMIAAKF--EESYPPSLSEFLFICEDMYEKSDMVSLESSILQTL 1258
Cdd:cd20523     15 YGFSPETFALAVNLLDRFLSKVKVKPKHLACITVSCFHIAIKSveEDQNIPSAEDLIRISQCGCTAADLMRMEGIILEKL 94
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 1166-1260 4.37e-04

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 40.96  E-value: 4.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1166 MRAILVDWLVEIQGSFQMTHETLYLAVKIMDLYLMKAQCKKNHLQLLGSTTYMIAAKF--EESYPPSLSEFLFICEDMYE 1243
Cdd:cd20583      1 LRDFEVKDLLSLTQFFGFSTETFSLAVNLLDRFLAKMKVQPKHLGCVGLSCFYLAVKAieEERNVPLATDLIRISQYRFT 80

                           90
                   ....*....|....*..
gi 1039796821 1244 KSDMVSLESSILQTLNF 1260
Cdd:cd20583     81 VSDMMRMEKIILEKLCW 97
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 1266-1347 2.22e-03

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 38.55  E-value: 2.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1266 TAYNFLRRYASCIHASMKTLTLSRFICEMTLQEYEYIEERPSKLAAASFILALYMRNLSNCVPTLEYFTGYKMAELHILV 1345
Cdd:cd00043      1 KAVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPRTLKEIAKVSGVSEKELRKAE 80


                   ..
gi 1039796821 1346 RK 1347
Cdd:cd00043     81 KE 82
CYCLIN_CCNF_rpt2 cd20522
second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, ...
 1287-1390 2.62e-03

second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410226  Cd Length: 112  Bit Score: 39.14  E-value: 2.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1287 LSRFICEMTLQEYEYIEERPSKLAAASFILALYMRNLSNCVPT-LEYFTGYKMAELHILVRKLNH-------LLNFRsHS 1358
Cdd:cd20522      2 LASYICELSLLHTELGRYSPAVIAASCLLLARVLLNQALPWPSqLEEFTGFSLEDLLSCVLHLHKkcfhedsPKDYR-NV 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1039796821 1359 ILKNVFEKYSEETYFEVAKIPPLSKQDLENLL 1390
Cdd:cd20522     81 SLTAVKQRYEDERFLSISKIKVMSYEELCALL 112
CYCLIN_CCNG2 cd20584
cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth ...
 1181-1259 8.18e-03

cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410287  Cd Length: 96  Bit Score: 37.13  E-value: 8.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796821 1181 FQMTHETLYLAVKIMDLYLMKAQCKKNHLQLLGSTTYMIAAKF--EESYPPSLSEFLFICEDMYEKSDMVSLESSILQTL 1258
Cdd:cd20584     16 FGFSTETFVLAVNILDRFLALMKVKPKHLSCIGICCFHLAARVveEECNIPSSHDLIRISQCKCTVSDLKRMEKIISEKL 95


                   .
gi 1039796821 1259 N 1259
Cdd:cd20584     96 H 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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