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Conserved domains on  [gi|1039797943|ref|XP_017174050|]
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WD repeat domain phosphoinositide-interacting protein 4 isoform X3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl43672
WD40 repeat [General function prediction only];
167-239 3.37e-04

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.21  E-value: 3.37e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039797943 167 GSLQLVDLASTKPgtssaPFTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPAT 239
Cdd:COG2319   310 GTVRLWDLATGKL-----LRTLTGHTGAVRSVAFSPDGKTLASGSDDGT-VRLWDLATGELLRTLTGHTGAVT 376
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
167-239 3.37e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.21  E-value: 3.37e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039797943 167 GSLQLVDLASTKPgtssaPFTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPAT 239
Cdd:COG2319   310 GTVRLWDLATGKL-----LRTLTGHTGAVRSVAFSPDGKTLASGSDDGT-VRLWDLATGELLRTLTGHTGAVT 376
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 186-224 1.88e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.63  E-value: 1.88e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1039797943 186 FTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQS 224
Cdd:cd00200   129 TTLRGHTDWVNSVAFSPDGTFVASSSQDGT-IKLWDLRT 166
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
167-239 3.37e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.21  E-value: 3.37e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039797943 167 GSLQLVDLASTKPgtssaPFTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPAT 239
Cdd:COG2319   310 GTVRLWDLATGKL-----LRTLTGHTGAVRSVAFSPDGKTLASGSDDGT-VRLWDLATGELLRTLTGHTGAVT 376
WD40 COG2319
WD40 repeat [General function prediction only];
167-239 4.80e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.82  E-value: 4.80e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039797943 167 GSLQLVDLASTKPGTssapfTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPAT 239
Cdd:COG2319   226 GTVRLWDLATGKLLR-----TLTGHSGSVRSVAFSPDGRLLASGSADGT-VRLWDLATGELLRTLTGHSGGVN 292
WD40 COG2319
WD40 repeat [General function prediction only];
167-260 9.14e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.66  E-value: 9.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039797943 167 GSLQLVDLASTKPgtssaPFTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDP--------- 237
Cdd:COG2319   184 GTVRLWDLATGKL-----LRTLTGHTGAVRSVAFSPDGKLLASGSADGT-VRLWDLATGKLLRTLTGHSGSvrsvafspd 257

                          90       100
                  ....*....|....*....|....*..
gi 1039797943 238 ----ATLYCDkGTVHIFALKDTRLNRR 260
Cdd:COG2319   258 grllASGSAD-GTVRLWDLATGELLRT 283
WD40 COG2319
WD40 repeat [General function prediction only];
167-239 9.22e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.66  E-value: 9.22e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039797943 167 GSLQLVDLASTKPgtssaPFTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPAT 239
Cdd:COG2319   100 GTVRLWDLATGLL-----LRTLTGHTGAVRSVAFSPDGKTLASGSADGT-VRLWDLATGKLLRTLTGHSGAVT 166
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 186-224 1.88e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.63  E-value: 1.88e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1039797943 186 FTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQS 224
Cdd:cd00200   129 TTLRGHTDWVNSVAFSPDGTFVASSSQDGT-IKLWDLRT 166
WD40 COG2319
WD40 repeat [General function prediction only];
167-237 2.43e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.51  E-value: 2.43e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039797943 167 GSLQLVDLASTKPGTssapfTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDP 237
Cdd:COG2319   142 GTVRLWDLATGKLLR-----TLTGHSGAVTSVAFSPDGKLLASGSDDGT-VRLWDLATGKLLRTLTGHTGA 206
WD40 COG2319
WD40 repeat [General function prediction only];
167-239 4.21e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 38.74  E-value: 4.21e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039797943 167 GSLQLVDLASTKPGTssapfTINAHQSDVACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPAT 239
Cdd:COG2319   268 GTVRLWDLATGELLR-----TLTGHSGGVNSVAFSPDGKLLASGSDDGT-VRLWDLATGKLLRTLTGHTGAVR 334
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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