NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1039765474|ref|XP_017175304|]
View 

tripartite motif-containing protein 2 isoform X9 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 195-468 0e+00

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


:

Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 569.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 195 DLIFRVGTKGRNKGEFTNLQGVAASTSGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIA 274
Cdd:cd14960     1 DLIFRIGTKGRNKGEFTNLQGVAASSSGRLVIADSNNQCVQVFSNDGQFKLRFGVRGRSPGQLQRPTGVAVTLNGDIIIA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 275 DYDNKWVSIFSNDGKFKTKIGSGKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAV 354
Cdd:cd14960    81 DYDNKWVSIFSPDGKFKSKIGAGKLMGPKGVAVDRNGHIIVVDNKACCVFIFQPNGKLVTRFGSRGNGDRQFAGPHFAAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 355 NSNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSYINTSA 434
Cdd:cd14960   161 NNNNEIIVTDFHNHSVKVFNAEGEFLFKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDSSGSFLSYINTSA 240

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1039765474 435 DPLYGPQGLALTSDGHVVVADSGNHCFKVYRYLQ 468
Cdd:cd14960   241 DPLYGPQGLALTSDGHVVVADSGNHCFKVYRYLQ 274
IG_FLMN smart00557
Filamin-type immunoglobulin domains; These form a rod-like structure in the actin-binding ...
 49-145 6.07e-24

Filamin-type immunoglobulin domains; These form a rod-like structure in the actin-binding cytoskeleton protein, filamin. The C-terminal repeats of filamin bind beta1-integrin (CD29).


:

Pssm-ID: 214720 [Multi-domain]  Cd Length: 93  Bit Score: 95.36  E-value: 6.07e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474   49 ASETVATGEGLRQTIIGQPMSVTITTKDKdgelcktGNAYLTAELSTPDGSVADGEILDNKNGTYEFLYTVQKEGDFTLS 128
Cdd:smart00557   1 ASKVKASGPGLEKGVVGEPAEFTVDTRDA-------GGGELEVEVTGPSGKKVPVEVKDNGDGTYTVSYTPTEPGDYTVT 73

                           90
                   ....*....|....*..
gi 1039765474  129 LRLYDQHIRGSPFKLKV 145
Cdd:smart00557  74 VKFGGEHIPGSPFTVKV 90
 
Name Accession Description Interval E-value
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 195-468 0e+00

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 569.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 195 DLIFRVGTKGRNKGEFTNLQGVAASTSGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIA 274
Cdd:cd14960     1 DLIFRIGTKGRNKGEFTNLQGVAASSSGRLVIADSNNQCVQVFSNDGQFKLRFGVRGRSPGQLQRPTGVAVTLNGDIIIA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 275 DYDNKWVSIFSNDGKFKTKIGSGKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAV 354
Cdd:cd14960    81 DYDNKWVSIFSPDGKFKSKIGAGKLMGPKGVAVDRNGHIIVVDNKACCVFIFQPNGKLVTRFGSRGNGDRQFAGPHFAAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 355 NSNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSYINTSA 434
Cdd:cd14960   161 NNNNEIIVTDFHNHSVKVFNAEGEFLFKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDSSGSFLSYINTSA 240

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1039765474 435 DPLYGPQGLALTSDGHVVVADSGNHCFKVYRYLQ 468
Cdd:cd14960   241 DPLYGPQGLALTSDGHVVVADSGNHCFKVYRYLQ 274
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
208-466 5.02e-28

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 112.04  E-value: 5.02e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 208 GEFTNLQGVAASTSGKILIADSNNQCVQIFS-NDGQFKSRfgirgrSPGQLQRPTGVAVHPSGDIIIADY-DNKWVSIFS 285
Cdd:COG4257    14 APGSGPRDVAVDPDGAVWFTDQGGGRIGRLDpATGEFTEY------PLGGGSGPHGIAVDPDGNLWFTDNgNNRIGRIDP 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 286 NDGKFKTKIGSGKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGdrqfAGPHFAAVNSNNEIIITDF 365
Cdd:COG4257    88 KTGEITTFALPGGGSNPHGIAFDPDGNLWFTDQGGNRIGRLDPATGEVTEFPLPTGG----AGPYGIAVDPDGNLWVTDF 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 366 HNHSVKVFNQEGEFMLKFgsngEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFD-GSGSFLSYinTSADPLYGPQGLA 444
Cdd:COG4257   164 GANAIGRIDPDTGTLTEY----ALPTPGAGPRGLAVDPDGNLWVADTGSGRIGRFDpKTGTVTEY--PLPGGGARPYGVA 237

                         250       260
                  ....*....|....*....|..
gi 1039765474 445 LTSDGHVVVADSGNHcfKVYRY 466
Cdd:COG4257   238 VDGDGRVWFAESGAN--RIVRF 257
IG_FLMN smart00557
Filamin-type immunoglobulin domains; These form a rod-like structure in the actin-binding ...
 49-145 6.07e-24

Filamin-type immunoglobulin domains; These form a rod-like structure in the actin-binding cytoskeleton protein, filamin. The C-terminal repeats of filamin bind beta1-integrin (CD29).


Pssm-ID: 214720 [Multi-domain]  Cd Length: 93  Bit Score: 95.36  E-value: 6.07e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474   49 ASETVATGEGLRQTIIGQPMSVTITTKDKdgelcktGNAYLTAELSTPDGSVADGEILDNKNGTYEFLYTVQKEGDFTLS 128
Cdd:smart00557   1 ASKVKASGPGLEKGVVGEPAEFTVDTRDA-------GGGELEVEVTGPSGKKVPVEVKDNGDGTYTVSYTPTEPGDYTVT 73

                           90
                   ....*....|....*..
gi 1039765474  129 LRLYDQHIRGSPFKLKV 145
Cdd:smart00557  74 VKFGGEHIPGSPFTVKV 90
Filamin pfam00630
Filamin/ABP280 repeat;
49-142 6.45e-21

Filamin/ABP280 repeat;


Pssm-ID: 395505  Cd Length: 89  Bit Score: 86.96  E-value: 6.45e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474  49 ASETVATGEGLRQTIIGQPMSVTITTKDKDGELcktgnaylTAELSTPDGSVADGEILDNKNGTYEFLYTVQKEGDFTLS 128
Cdd:pfam00630   4 ASKVKASGPGLEPGVVGKPAEFTVDTRDAGGEG--------EVEVTGPDGSPVPVEVTDNGDGTYTVSYTPTEPGDYTVS 75

                          90
                  ....*....|....
gi 1039765474 129 LRLYDQHIRGSPFK 142
Cdd:pfam00630  76 VKFNGQHIPGSPFK 89
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 393-420 1.52e-07

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 47.40  E-value: 1.52e-07
                          10        20
                  ....*....|....*....|....*...
gi 1039765474 393 FNAPTGVAVDSNGNIIVADWGNSRIQVF 420
Cdd:pfam01436   1 FNRPHGVAVDSNGDIYVADSENHRVQVF 28
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
 235-421 1.04e-04

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 44.84  E-value: 1.04e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474  235 QIFSNDGQFKSRFGIRGRSPGQLQrPTGVAVHPSGD-IIIADYDNKwvSIFSNDgkFKTKiGSGKLMGpkgvsvdrnGHI 313
Cdd:PLN02919   718 RVFSGDGYERNLNGSSGTSTSFAQ-PSGISLSPDLKeLYIADSESS--SIRALD--LKTG-GSRLLAG---------GDP 782

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474  314 IVVDNkaccvfIFQpngkivtrFGSR-GNGDR-QFAGPHFAAVNSNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGN- 390
Cdd:PLN02919   783 TFSDN------LFK--------FGDHdGVGSEvLLQHPLGVLCAKDGQIYVADSYNHKIKKLDPATKRVTTLAGTGKAGf 848

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1039765474  391 -------GQFNAPTGVAVDSNGNIIVADWGNSRIQVFD 421
Cdd:PLN02919   849 kdgkalkAQLSEPAGLALGENGRLFVADTNNSLIRYLD 886
ScyE_fam NF033206
ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin ...
 393-454 1.28e-03

ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin biosynthesis and export, and its paralog ScyD. Some members of the family contain a C-terminal PEP-CTERM domain that predictions anchoring to the outer membrane.


Pssm-ID: 467996 [Multi-domain]  Cd Length: 330  Bit Score: 40.72  E-value: 1.28e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039765474 393 FNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSfLSYI------NTSADPLYGPQGLALTSDGHVVVA 454
Cdd:NF033206  249 FTGLTDLAFDPDGNLYVLELAGGGLLKGDPTGS-LIRIapdgtrTTLLDGLELPTGLAVGPDGTLYVT 315
 
Name Accession Description Interval E-value
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 195-468 0e+00

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 569.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 195 DLIFRVGTKGRNKGEFTNLQGVAASTSGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIA 274
Cdd:cd14960     1 DLIFRIGTKGRNKGEFTNLQGVAASSSGRLVIADSNNQCVQVFSNDGQFKLRFGVRGRSPGQLQRPTGVAVTLNGDIIIA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 275 DYDNKWVSIFSNDGKFKTKIGSGKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAV 354
Cdd:cd14960    81 DYDNKWVSIFSPDGKFKSKIGAGKLMGPKGVAVDRNGHIIVVDNKACCVFIFQPNGKLVTRFGSRGNGDRQFAGPHFAAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 355 NSNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSYINTSA 434
Cdd:cd14960   161 NNNNEIIVTDFHNHSVKVFNAEGEFLFKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDSSGSFLSYINTSA 240

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1039765474 435 DPLYGPQGLALTSDGHVVVADSGNHCFKVYRYLQ 468
Cdd:cd14960   241 DPLYGPQGLALTSDGHVVVADSGNHCFKVYRYLQ 274
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 204-464 2.29e-92

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 281.13  E-value: 2.29e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 204 GRNKGEFTNLQGVAASTSGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIADYDNKWVSI 283
Cdd:cd05819     1 GTGPGELNNPQGIAVDSSGNIYVADTGNNRIQVFDPDGNFITSFGSFGSGDGQFNEPAGVAVDSDGNLYVADTGNHRIQK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 284 FSNDGKFKTKIGS-----GKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAVNSNN 358
Cdd:cd05819    81 FDPDGNFLASFGGsgdgdGEFNGPRGIAVDSSGNIYVADTGNHRIQKFDPDGEFLTTFGSGGSGPGQFNGPTGVAVDSDG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 359 EIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLS---YINTSAD 435
Cdd:cd05819   161 NIYVADTGNHRIQVFDPDGNFLTTFGSTGTGPGQFNYPTGIAVDSDGNIYVADSGNNRVQVFDPDGAGFGgngNFLGSDG 240

                         250       260
                  ....*....|....*....|....*....
gi 1039765474 436 PLYGPQGLALTSDGHVVVADSGNHCFKVY 464
Cdd:cd05819   241 QFNRPSGLAVDSDGNLYVADTGNNRIQVF 269
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 196-464 5.54e-89

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 272.88  E-value: 5.54e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 196 LIFRVGTKGRNKGEFTNLQGVAASTSGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIAD 275
Cdd:cd14954     9 PLLSFGKEGSKDGELCRPWGVAVDKDGRIIVADRSNNRVQVFDPDGKFLRKFGSYGSRDGQFDRPAGVAVNSRGRIIVAD 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 276 YDNKWVSIFSNDGKFKTKIGS-----GKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPH 350
Cdd:cd14954    89 KDNHRIQVFDLNGRFLLKFGErgtknGQFNYPWGVAVDSEGRIYVSDTRNHRVQVFDSDGQFIRKFGFEGAGPGQLDSPR 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 351 FAAVNSNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSYI 430
Cdd:cd14954   169 GVAVNPDGNIVVSDFNNHRLQVFDPDGQFLRFFGSEGSGNGQFKRPRGVAVDDEGNIIVADSGNHRVQVFSPDGEFLCSF 248

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1039765474 431 NT---SADPLYGPQGLALTSDGHVVVADSGNHCFKVY 464
Cdd:cd14954   249 GTegnGEGQFDRPSGVAVTPDGRIVVVDRGNHRIQVF 285
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 201-460 1.15e-76

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 240.94  E-value: 1.15e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 201 GTKGRNKGEFTNLQGVAASTSGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIADYDNKW 280
Cdd:cd14955     6 GSYGSGDGQFNSPSGIAVDSAGNVYVADTGNNRIQKFDSTGTFLTKWGSSGSGDGQFYSPTGIAVDSDGNVYVADTGNHR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 281 VSIFSNDGKFKTKIGS-----GKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAVN 355
Cdd:cd14955    86 IQKFDSTGTFLTKWGSsgsgdGQFNSPSGIAVDSAGNVYVTDSGNNRIQKFDSSGTFITKWGSFGSGDGQFNSPTGIAVD 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 356 SNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLS---YINT 432
Cdd:cd14955   166 SAGNVYVADTGNNRIQKFTSTGTFLTKWGSEGSGDGQFNAPYGIAVDSAGNVYVADTGNNRIQKFDSSGTFITkwgSEGS 245

                         250       260
                  ....*....|....*....|....*...
gi 1039765474 433 SADPLYGPQGLALTSDGHVVVADSGNHC 460
Cdd:cd14955   246 GDGQFNSPSGIAVDSAGNVYVADSGNNR 273
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 194-465 2.05e-67

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 217.13  E-value: 2.05e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 194 DDLIFRVGTKGRNKGEFTNLQGVAASTSGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIII 273
Cdd:cd14957     1 ASFSYAFGSNGSGNGQFNTPRGIAVDSAGNIYVADTGNNRIQVFTSSGVYSYSIGSGGTGSGQFNSPYGIAVDSNGNIYV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 274 ADYDNKWVSIFSNDGKFKTKIGS-----GKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAG 348
Cdd:cd14957    81 ADTDNNRIQVFNSSGVYQYSIGTggsgdGQFNGPYGIAVDSNGNIYVADTGNHRIQVFTSSGTFSYSIGSGGTGPGQFNG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 349 PHFAAVNSNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLS 428
Cdd:cd14957   161 PQGIAVDSDGNIYVADTGNHRIQVFTSSGTFQYTFGSSGSGPGQFSDPYGIAVDSDGNIYVADTGNHRIQVFTSSGAYQY 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1039765474 429 YINTSADPLYG---PQGLALTSDGHVVVADSGNHCFKVYR 465
Cdd:cd14957   241 SIGTSGSGNGQfnyPYGIAVDNDGKIYVADSNNNRIQVFN 280
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 201-459 1.70e-66

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 214.45  E-value: 1.70e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 201 GTKGRNKGEFTNLQGVAASTSGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIADYDNKW 280
Cdd:cd14956     3 GGRGSGPGQFKDPRGIAVDADDNVYVADARNGRIQVFDKDGTFLRRFGTTGDGPGQFGRPRGLAVDKDGWLYVADYWGDR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 281 VSIFSNDGKFKTKIGS-----GKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAVN 355
Cdd:cd14956    83 IQVFTLTGELQTIGGSsgsgpGQFNAPRGVAVDADGNLYVADFGNQRIQKFDPDGSFLRQWGGTGIEPGSFNYPRGVAVD 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 356 SNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSYINTSAD 435
Cdd:cd14956   163 PDGTLYVADTYNDRIQVFDNDGAFLRKWGGRGTGPGQFNYPYGIAIDPDGNVFVADFGNNRIQKFTADGTFLTSWGSPGT 242

                         250       260
                  ....*....|....*....|....*..
gi 1039765474 436 ---PLYGPQGLALTSDGHVVVADSGNH 459
Cdd:cd14956   243 gpgQFKNPWGVVVDADGTVYVADSNNN 269
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 237-459 1.89e-62

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 204.32  E-value: 1.89e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 237 FSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIADYDNKWVSIFSNDGKFKTKIGS-----GKLMGPKGVSVDRNG 311
Cdd:cd14954     3 YRAKGRPLLSFGKEGSKDGELCRPWGVAVDKDGRIIVADRSNNRVQVFDPDGKFLRKFGSygsrdGQFDRPAGVAVNSRG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 312 HIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAVNSNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNG 391
Cdd:cd14954    83 RIIVADKDNHRIQVFDLNGRFLLKFGERGTKNGQFNYPWGVAVDSEGRIYVSDTRNHRVQVFDSDGQFIRKFGFEGAGPG 162

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039765474 392 QFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSYINTSAD---PLYGPQGLALTSDGHVVVADSGNH 459
Cdd:cd14954   163 QLDSPRGVAVNPDGNIVVSDFNNHRLQVFDPDGQFLRFFGSEGSgngQFKRPRGVAVDDEGNIIVADSGNH 233
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 201-465 3.50e-59

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 195.57  E-value: 3.50e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 201 GTKGRNKGEFTNLQGVAASTSGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIADYDNKW 280
Cdd:cd14961     1 GSFGGWPGTLNNPTGVAVTPTGRVVVADDGNKRIQVFDSDGNCLQQFGPKGDAGQDIRYPLDVAVTPDGHIVVTDAGDRS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 281 VSIFSNDGKFKTKIGSGKLMgPKGVSVDRNGHIIVVDNKACCVFIFQPNGKiVTRFGSRGNGDRQFAGPHFAAVNSNNEI 360
Cdd:cd14961    81 VKVFSFDGRLKLFVRKSFSL-PWGVAVNPSGEILVTDSEAGKLFVLTVDFK-LGILKKGQKLCSQLCRPRFVAVSRLGAV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 361 IITD--------FHNHSVKVFNQEGEF---MLKFGsNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSY 429
Cdd:cd14961   159 AVTEhlfangtrSSSTRVKVFSSGGQLlgqIDSFG-LNLVFPSLICASGVAFDSEGNVIVADTGSGAILCLGKPEGFPIL 237

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1039765474 430 INTSADPLYGPQGLALTSDGHVVVADSGNHCFKVYR 465
Cdd:cd14961   238 KPIVTQGLSRPVGLAVTPDGSLVVLDSGNHCVKIYK 273
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 201-421 4.77e-56

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 187.40  E-value: 4.77e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 201 GTKGRNKGEFTNLQGVAASTSGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIADYDNKW 280
Cdd:cd14955    53 GSSGSGDGQFYSPTGIAVDSDGNVYVADTGNHRIQKFDSTGTFLTKWGSSGSGDGQFNSPSGIAVDSAGNVYVTDSGNNR 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 281 VSIFSNDGKFKTKIGS-----GKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAVN 355
Cdd:cd14955   133 IQKFDSSGTFITKWGSfgsgdGQFNSPTGIAVDSAGNVYVADTGNNRIQKFTSTGTFLTKWGSEGSGDGQFNAPYGIAVD 212

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039765474 356 SNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFD 421
Cdd:cd14955   213 SAGNVYVADTGNNRIQKFDSSGTFITKWGSEGSGDGQFNSPSGIAVDSAGNVYVADSGNNRIQKFA 278
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 243-459 1.31e-54

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 183.93  E-value: 1.31e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 243 FKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIADYDNKWVSIFSNDGKFKTKIGS-----GKLMGPKGVSVDRNGHIIVVD 317
Cdd:cd14955     1 FVTQWGSYGSGDGQFNSPSGIAVDSAGNVYVADTGNNRIQKFDSTGTFLTKWGSsgsgdGQFYSPTGIAVDSDGNVYVAD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 318 NKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAVNSNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPT 397
Cdd:cd14955    81 TGNHRIQKFDSTGTFLTKWGSSGSGDGQFNSPSGIAVDSAGNVYVTDSGNNRIQKFDSSGTFITKWGSFGSGDGQFNSPT 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039765474 398 GVAVDSNGNIIVADWGNSRIQVFDGSGSFLSYINTS---ADPLYGPQGLALTSDGHVVVADSGNH 459
Cdd:cd14955   161 GIAVDSAGNVYVADTGNNRIQKFTSTGTFLTKWGSEgsgDGQFNAPYGIAVDSAGNVYVADTGNN 225
NHL_brat_like cd14959
NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; ...
 195-467 7.14e-54

NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; Drosophila brain-tumor (brat) has been identified as a tumor suppressor that negatively regulates cell proliferation during development of the Drosophila larval brain. It appears to be recruited to the 3'-untranslated region of hunchback RNA and regulates its translation by forming a complex with Pumilio (Pum) and Nanos (Nos). The NHL domain of brat appears to be involved by interacting with the RNA-binding Puf repeats of Pumilio, a sequence-specific RNA binding protein. This family also contains the Caenorhabditis elegans homolog NCL-1. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271329 [Multi-domain]  Cd Length: 274  Bit Score: 181.70  E-value: 7.14e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 195 DLIFR--VGTKGRNKGEFTNLQGVAASTSGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAV-HPSGDI 271
Cdd:cd14959     4 KMIIHckFGESGSGEGQFNSPSGFCLGEDEDILVADTNNHRIQVFDKEGEFKFQFGIPGKRDGQLWYPNKVAVcRVTGRY 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 272 IIADYDNK--WVSIFSNDGKFKTKIGSGKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSrgngDRQFAGP 349
Cdd:cd14959    84 VVTDRGNPrhRMQIFTKRGQFVRKFGARYLQHVRGLTVDAAGHIIVVESKVMRVFIFDESGNVLKWFDC----SKYLEEP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 350 HFAAVNsNNEIIITDFHNHSVKVFNQEGEFMLKFGsngeGNGQFNAPTGVAVDSNGNIIVADWGNSR--IQVFDGSGSFL 427
Cdd:cd14959   160 SDVAVN-DNEIYICDNKGHCVVVFNYDGQFLRRIG----GEGITNYPIGVDISSAGDVLVADNHGNHfhVTVFTRDGQLI 234

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1039765474 428 SYINTSADPLYGPQGLALTSDGHVVVADSGNHCFKVYRYL 467
Cdd:cd14959   235 SEFECPRVKHSRCCGLALTSEGSIVTLSKHNHHVLVFNTL 274
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 214-467 8.57e-52

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 176.24  E-value: 8.57e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 214 QGVAASTSGKILIADSNNQCVQIFsnDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIADYDNKWVSIFSNDGKFKTK 293
Cdd:cd14962    15 YGVAADGRGRIYVADTGRGAVFVF--DLPNGKVFVIGNAGPNRFVSPIGVAIDANGNLYVSDAELGKVFVFDRDGKFLRA 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 294 IGSGKLMG-PKGVSVD-RNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAVNSNNEIIITDFHNHSVK 371
Cdd:cd14962    93 IGAGALFKrPTGIAVDpAGKRLYVVDTLAHKVKVFDLDGRLLFDIGKRGSGPGEFNLPTDLAVDRDGNLYVTDTMNFRVQ 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 372 VFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSYI-NTSADP--LYGPQGLALTSD 448
Cdd:cd14962   173 IFDADGKFLRSFGERGDGPGSFARPKGIAVDSEGNIYVVDAAFDNVQIFNPEGELLLTVgGPGSGPgeFYLPSGIAIDKD 252

                         250
                  ....*....|....*....
gi 1039765474 449 GHVVVADSGNHCFKVYRYL 467
Cdd:cd14962   253 DRIYVVDQFNRRIQVFQYL 271
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 215-464 3.04e-51

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 174.40  E-value: 3.04e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 215 GVAAStSGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIADYDNKWVSIFSNDGKFKTKI 294
Cdd:cd14963    14 GVAVS-DGRIYVADTNNHRVQVFDYEGKFKKSFGGPGTGPGEFKYPYGIAVDSDGNIYVADLYNGRIQVFDPDGKFLKYF 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 295 GSGK----LMGPKGVSVDRnGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAVNSNNEIIITDFHNHSV 370
Cdd:cd14963    93 PEKKdrvkLISPAGLAIDD-GKLYVSDVKKHKVIVFDLEGKLLLEFGKPGSEPGELSYPNGIAVDEDGNIYVADSGNGRI 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 371 KVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSYINTSAD---PLYGPQGLALTS 447
Cdd:cd14963   172 QVFDKNGKFIKELNGSPDGKSGFVNPRGIAVDPDGNLYVVDNLSHRVYVFDEQGKELFTFGGRGKddgQFNLPNGLFIDD 251

                         250
                  ....*....|....*..
gi 1039765474 448 DGHVVVADSGNHCFKVY 464
Cdd:cd14963   252 DGRLYVTDRENNRVAVY 268
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 192-420 3.32e-48

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 166.73  E-value: 3.32e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 192 IEDDLIFRVGTKGRNKGEFTNLQGVAASTSGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDI 271
Cdd:cd05819    83 PDGNFLASFGGSGDGDGEFNGPRGIAVDSSGNIYVADTGNHRIQKFDPDGEFLTTFGSGGSGPGQFNGPTGVAVDSDGNI 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 272 IIADYDNkwvsifsndgkfktkigsgklmgpkgvsvdrnghiivvdnkaCCVFIFQPNGKIVTRFGSRGNGDRQFAGPHF 351
Cdd:cd05819   163 YVADTGN------------------------------------------HRIQVFDPDGNFLTTFGSTGTGPGQFNYPTG 200

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039765474 352 AAVNSNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVF 420
Cdd:cd05819   201 IAVDSDGNIYVADSGNNRVQVFDPDGAGFGGNGNFLGSDGQFNRPSGLAVDSDGNLYVADTGNNRIQVF 269
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 197-420 1.97e-44

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 156.68  E-value: 1.97e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 197 IFRVGTKGRNKGEFTNLQGVAASTSGKILIADSNNQCVQIFSNDGQFKSRFGiRGRSPGQLQRPTGVAVHpSGDIIIADY 276
Cdd:cd14963    42 KKSFGGPGTGPGEFKYPYGIAVDSDGNIYVADLYNGRIQVFDPDGKFLKYFP-EKKDRVKLISPAGLAID-DGKLYVSDV 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 277 DNKWVSIFSNDGKFKTKIGS-----GKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHF 351
Cdd:cd14963   120 KKHKVIVFDLEGKLLLEFGKpgsepGELSYPNGIAVDEDGNIYVADSGNGRIQVFDKNGKFIKELNGSPDGKSGFVNPRG 199

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039765474 352 AAVNSNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVF 420
Cdd:cd14963   200 IAVDPDGNLYVVDNLSHRVYVFDEQGKELFTFGGRGKDDGQFNLPNGLFIDDDGRLYVTDRENNRVAVY 268
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 199-420 1.06e-41

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 149.27  E-value: 1.06e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 199 RVGTKGRNKGE-FTNLQGVAASTSGKILIADSNNQCVQIFSNDGQFKSRFGirgrSPGQLQRPTGVAVHPSGD-IIIADY 276
Cdd:cd14962    44 KVFVIGNAGPNrFVSPIGVAIDANGNLYVSDAELGKVFVFDRDGKFLRAIG----AGALFKRPTGIAVDPAGKrLYVVDT 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 277 DNKWVSIFSNDGKFKTKIGS-----GKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHF 351
Cdd:cd14962   120 LAHKVKVFDLDGRLLFDIGKrgsgpGEFNLPTDLAVDRDGNLYVTDTMNFRVQIFDADGKFLRSFGERGDGPGSFARPKG 199

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039765474 352 AAVNSNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVF 420
Cdd:cd14962   200 IAVDSEGNIYVVDAAFDNVQIFNPEGELLLTVGGPGSGPGEFYLPSGIAIDKDDRIYVVDQFNRRIQVF 268
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 332-460 2.00e-36

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 135.40  E-value: 2.00e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 332 IVTRFGSRGNGDRQFAGPHFAAVNSNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVAD 411
Cdd:cd14955     1 FVTQWGSYGSGDGQFNSPSGIAVDSAGNVYVADTGNNRIQKFDSTGTFLTKWGSSGSGDGQFYSPTGIAVDSDGNVYVAD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1039765474 412 WGNSRIQVFDGSGSFLSYINTSAD---PLYGPQGLALTSDGHVVVADSGNHC 460
Cdd:cd14955    81 TGNHRIQKFDSTGTFLTKWGSSGSgdgQFNSPSGIAVDSAGNVYVTDSGNNR 132
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 210-459 2.25e-35

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 133.81  E-value: 2.25e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 210 FTNLQGVAASTSGKILIADSNNQCVQIFSNDGQfKSRF---GIRGRSPG-----QLQRPTGVAVHPSGDIIIADYDNKWV 281
Cdd:cd14953    22 FNSPSGVAVDAAGNLYVADRGNHRIRKITPDGV-VTTVagtGTAGFADGggaaaQFNTPSGVAVDAAGNLYVADTGNHRI 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 282 SIFSNDGKFKTKIGSG-------------KLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVT-----RFGSRGNG- 342
Cdd:cd14953   101 RKITPDGVVSTLAGTGtagfsddggataaQFNYPTGVAVDAAGNLYVADTGNHRIRKITPDGVVTTvagtgGAGYAGDGp 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 343 --DRQFAGPHFAAVNSNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEG--------NGQFNAPTGVAVDSNGNIIVADW 412
Cdd:cd14953   181 atAAQFNNPTGVAVDAAGNLYVADRGNHRIRKITPDGVVTTVAGTGTAGfsgdggatAAQLNNPTGVAVDAAGNLYVADS 260

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1039765474 413 GNSRI----------QVFDGSGSFLSYINTSAD-PLYGPQGLALTSDGHVVVADSGNH 459
Cdd:cd14953   261 GNHRIrkitpagvvtTVAGGGAGFSGDGGPATSaQFNNPTGVAVDAAGNLYVADTGNN 318
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 254-458 5.96e-32

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 123.91  E-value: 5.96e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 254 PGQLQRPTGVAVHPSGDIII-ADYDNKWVS--------------------IFSNDGKFKTKIGSGKLMGPKGVSVDRNGH 312
Cdd:cd14958     9 SLKLGQVSGVAVDSLGNGVVfHRGGRVWDAnsfdanvyvfkgpieedtilVFDPDGGFLRSWGAGLFYMPHGLTIDPDGN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 313 IIVVDNKACCVFIFQPNGKIVTR--FGSR---GNGDRQFAGPHFAAVNSNNEIIITDFH-NHSVKVFNQEGEFMLKFGSN 386
Cdd:cd14958    89 IWVTDVGLHQVFKFDPEGKLLPLltLGERgepGSDQTHFCKPTDVAVAPDGDIFVADGYcNSRIVKFSPDGKLLKSWGEP 168

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039765474 387 GEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLS-YINTSADPLYgpqGLALTSDGHVVVADSGN 458
Cdd:cd14958   169 GSGPGQFNLPHSIALDEDGRVYVADRENGRIQVFDADGKFLTeWTNPELGRPY---ALAIDPDGLLYVVDGPP 238
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
208-466 5.02e-28

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 112.04  E-value: 5.02e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 208 GEFTNLQGVAASTSGKILIADSNNQCVQIFS-NDGQFKSRfgirgrSPGQLQRPTGVAVHPSGDIIIADY-DNKWVSIFS 285
Cdd:COG4257    14 APGSGPRDVAVDPDGAVWFTDQGGGRIGRLDpATGEFTEY------PLGGGSGPHGIAVDPDGNLWFTDNgNNRIGRIDP 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 286 NDGKFKTKIGSGKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGdrqfAGPHFAAVNSNNEIIITDF 365
Cdd:COG4257    88 KTGEITTFALPGGGSNPHGIAFDPDGNLWFTDQGGNRIGRLDPATGEVTEFPLPTGG----AGPYGIAVDPDGNLWVTDF 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 366 HNHSVKVFNQEGEFMLKFgsngEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFD-GSGSFLSYinTSADPLYGPQGLA 444
Cdd:COG4257   164 GANAIGRIDPDTGTLTEY----ALPTPGAGPRGLAVDPDGNLWVADTGSGRIGRFDpKTGTVTEY--PLPGGGARPYGVA 237

                         250       260
                  ....*....|....*....|..
gi 1039765474 445 LTSDGHVVVADSGNHcfKVYRY 466
Cdd:COG4257   238 VDGDGRVWFAESGAN--RIVRF 257
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 340-464 3.95e-26

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 106.99  E-value: 3.95e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 340 GNGDRQFAGPHFAAVnSNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQV 419
Cdd:cd14963     3 GPFGDPLNKPMGVAV-SDGRIYVADTNNHRVQVFDYEGKFKKSFGGPGTGPGEFKYPYGIAVDSDGNIYVADLYNGRIQV 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1039765474 420 FDGSGSFLSYINTSAD--PLYGPQGLALtSDGHVVVADSGNHCFKVY 464
Cdd:cd14963    82 FDPDGKFLKYFPEKKDrvKLISPAGLAI-DDGKLYVSDVKKHKVIVF 127
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
254-466 4.39e-26

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 106.64  E-value: 4.39e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 254 PGQLQRPTGVAVHPSGDIIIADYDNKWVSIFS-NDGKFkTKIGSGKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKI 332
Cdd:COG4257    13 PAPGSGPRDVAVDPDGAVWFTDQGGGRIGRLDpATGEF-TEYPLGGGSGPHGIAVDPDGNLWFTDNGNNRIGRIDPKTGE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 333 VTRFGSRGNGdrqfAGPHFAAVNSNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGqfnaPTGVAVDSNGNIIVADW 412
Cdd:COG4257    92 ITTFALPGGG----SNPHGIAFDPDGNLWFTDQGGNRIGRLDPATGEVTEFPLPTGGAG----PYGIAVDPDGNLWVTDF 163

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1039765474 413 GNSRIQVFDGSGSFLSYINTSAdPLYGPQGLALTSDGHVVVADSGNHcfKVYRY 466
Cdd:COG4257   164 GANAIGRIDPDTGTLTEYALPT-PGAGPRGLAVDPDGNLWVADTGSG--RIGRF 214
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 201-417 1.08e-24

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 104.15  E-value: 1.08e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 201 GTKGRNKG-----EFTNLQGVAASTSGKILIADSNNQCVQIFSNDGQFkSRF---GIRGRSPG------QLQRPTGVAVH 266
Cdd:cd14953    62 GTAGFADGggaaaQFNTPSGVAVDAAGNLYVADTGNHRIRKITPDGVV-STLagtGTAGFSDDggataaQFNYPTGVAVD 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 267 PSGDIIIADYDNKWVSIFSNDGKFKTKIGSG-------------KLMGPKGVSVDRNGHIIVVD---NKACCVFifqPNG 330
Cdd:cd14953   141 AAGNLYVADTGNHRIRKITPDGVVTTVAGTGgagyagdgpataaQFNNPTGVAVDAAGNLYVADrgnHRIRKIT---PDG 217

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 331 KIVTRFGSRGNGDR--------QFAGPHFAAVNSNNEIIITDFHNHSVKVFNQEGEFM----LKFGSNGEGNG----QFN 394
Cdd:cd14953   218 VVTTVAGTGTAGFSgdggataaQLNNPTGVAVDAAGNLYVADSGNHRIRKITPAGVVTtvagGGAGFSGDGGPatsaQFN 297

                         250       260
                  ....*....|....*....|...
gi 1039765474 395 APTGVAVDSNGNIIVADWGNSRI 417
Cdd:cd14953   298 NPTGVAVDAAGNLYVADTGNNRI 320
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 299-464 5.74e-24

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 100.74  E-value: 5.74e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 299 LMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRG-------------------------------NGDRQFA 347
Cdd:cd14962    11 LTRPYGVAADGRGRIYVADTGRGAVFVFDLPNGKVFVIGNAGpnrfvspigvaidangnlyvsdaelgkvfvfDRDGKFL 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 348 G----------PHFAAVNS-NNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSR 416
Cdd:cd14962    91 RaigagalfkrPTGIAVDPaGKRLYVVDTLAHKVKVFDLDGRLLFDIGKRGSGPGEFNLPTDLAVDRDGNLYVTDTMNFR 170

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1039765474 417 IQVFDGSGSFLSYINTSADPlYG----PQGLALTSDGHVVVADSGNHCFKVY 464
Cdd:cd14962   171 VQIFDADGKFLRSFGERGDG-PGsfarPKGIAVDSEGNIYVVDAAFDNVQIF 221
IG_FLMN smart00557
Filamin-type immunoglobulin domains; These form a rod-like structure in the actin-binding ...
 49-145 6.07e-24

Filamin-type immunoglobulin domains; These form a rod-like structure in the actin-binding cytoskeleton protein, filamin. The C-terminal repeats of filamin bind beta1-integrin (CD29).


Pssm-ID: 214720 [Multi-domain]  Cd Length: 93  Bit Score: 95.36  E-value: 6.07e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474   49 ASETVATGEGLRQTIIGQPMSVTITTKDKdgelcktGNAYLTAELSTPDGSVADGEILDNKNGTYEFLYTVQKEGDFTLS 128
Cdd:smart00557   1 ASKVKASGPGLEKGVVGEPAEFTVDTRDA-------GGGELEVEVTGPSGKKVPVEVKDNGDGTYTVSYTPTEPGDYTVT 73

                           90
                   ....*....|....*..
gi 1039765474  129 LRLYDQHIRGSPFKLKV 145
Cdd:smart00557  74 VKFGGEHIPGSPFTVKV 90
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 201-328 7.02e-24

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 100.73  E-value: 7.02e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 201 GTKGRNKGEFTNLQGVAASTSGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIADYDNKW 280
Cdd:cd14955   147 GSFGSGDGQFNSPTGIAVDSAGNVYVADTGNNRIQKFTSTGTFLTKWGSEGSGDGQFNAPYGIAVDSAGNVYVADTGNNR 226

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1039765474 281 VSIFSNDGKFKTKIGS-----GKLMGPKGVSVDRNGHIIVVDNKACCVFIFQP 328
Cdd:cd14955   227 IQKFDSSGTFITKWGSegsgdGQFNSPSGIAVDSAGNVYVADSGNNRIQKFAP 279
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
208-429 1.90e-22

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 96.63  E-value: 1.90e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 208 GEFTNLQGVAASTSGKILIADSNNQCVQIFS-NDGQFKsRFGIrgrsPGQLQRPTGVAVHPSGDIIIADYDNKWVSIFS- 285
Cdd:COG4257    56 GGGSGPHGIAVDPDGNLWFTDNGNNRIGRIDpKTGEIT-TFAL----PGGGSNPHGIAFDPDGNLWFTDQGGNRIGRLDp 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 286 NDGKFKTKIGSGKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFgsrgNGDRQFAGPHFAAVNSNNEIIITDF 365
Cdd:COG4257   131 ATGEVTEFPLPTGGAGPYGIAVDPDGNLWVTDFGANAIGRIDPDTGTLTEY----ALPTPGAGPRGLAVDPDGNLWVADT 206

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039765474 366 HNHSVKVFN----QEGEFMLKFGSNGegngqfnaPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSY 429
Cdd:COG4257   207 GSGRIGRFDpktgTVTEYPLPGGGAR--------PYGVAVDGDGRVWFAESGANRIVRFDPDTELTEY 266
Filamin pfam00630
Filamin/ABP280 repeat;
49-142 6.45e-21

Filamin/ABP280 repeat;


Pssm-ID: 395505  Cd Length: 89  Bit Score: 86.96  E-value: 6.45e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474  49 ASETVATGEGLRQTIIGQPMSVTITTKDKDGELcktgnaylTAELSTPDGSVADGEILDNKNGTYEFLYTVQKEGDFTLS 128
Cdd:pfam00630   4 ASKVKASGPGLEPGVVGKPAEFTVDTRDAGGEG--------EVEVTGPDGSPVPVEVTDNGDGTYTVSYTPTEPGDYTVS 75

                          90
                  ....*....|....
gi 1039765474 129 LRLYDQHIRGSPFK 142
Cdd:pfam00630  76 VKFNGQHIPGSPFK 89
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 210-459 7.13e-20

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 88.80  E-value: 7.13e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 210 FTNL---QGVAASTSGKILIADS-NNQCVQIFSN-DGQFKSRFGirgrspgQLQRPTGVAVHPSGDIIIADYDNKWVSIF 284
Cdd:cd14952     6 FTGLdgpGGVAVDAAGNVYVADSgNNRVLKLAAGsTTQTVLPFT-------GLYQPQGVAVDAAGTVYVTDFGNNRVLKL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 285 SNDGKFKTKIGSGKLMGPKGVSVDRNGHIIVVDNkaccvfifqPNGKIVTRF-GSRGNGDRQFAG---PHFAAVNSNNEI 360
Cdd:cd14952    79 AAGSTTQTVLPFTGLNDPTGVAVDAAGNVYVADT---------GNNRVLKLAaGSNTQTVLPFTGlsnPDGVAVDGAGNV 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 361 IITDFHNHSVkvfnqegeFMLKFGSNGEGNGQF---NAPTGVAVDSNGNIIVADWGNSRIQVFDgSGSflsyiNTSA--- 434
Cdd:cd14952   150 YVTDTGNNRV--------LKLAAGSTTQTVLPFtglNSPSGVAVDTAGNVYVTDHGNNRVLKLA-AGS-----TTPTvlp 215

                         250       260
                  ....*....|....*....|....*.
gi 1039765474 435 -DPLYGPQGLALTSDGHVVVADSGNH 459
Cdd:cd14952   216 fTGLNGPLGVAVDAAGNVYVADRGND 241
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 256-459 1.29e-19

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 89.51  E-value: 1.29e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 256 QLQRPTGVAVHPSGDIIIADYDNKWVSIFSNDGKFKTKIGSG------------KLMGPKGVSVDRNGHIIVVDNKACCV 323
Cdd:cd14953    21 RFNSPSGVAVDAAGNLYVADRGNHRIRKITPDGVVTTVAGTGtagfadgggaaaQFNTPSGVAVDAAGNLYVADTGNHRI 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 324 FIFQPNGKIVTRFGSRGNGDRqfagphfaavnsnneiiitdfhnhsvkvfnqegefmlkfGSNGEGNGQFNAPTGVAVDS 403
Cdd:cd14953   101 RKITPDGVVSTLAGTGTAGFS---------------------------------------DDGGATAAQFNYPTGVAVDA 141

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039765474 404 NGNIIVADWGNSRIQV---------FDGSGSFLSYINTSADP--LYGPQGLALTSDGHVVVADSGNH 459
Cdd:cd14953   142 AGNLYVADTGNHRIRKitpdgvvttVAGTGGAGYAGDGPATAaqFNNPTGVAVDAAGNLYVADRGNH 208
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 304-462 1.40e-19

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 88.86  E-value: 1.40e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 304 GVSVDRNGHIIVV-------DNKACCVFIFQPNGKI----VTRFGSRGN-----GDRQFAGPHFAAVNSNNEIIITDFHN 367
Cdd:cd14958    17 GVAVDSLGNGVVFhrggrvwDANSFDANVYVFKGPIeedtILVFDPDGGflrswGAGLFYMPHGLTIDPDGNIWVTDVGL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 368 HSVKVFNQEGE--FMLKFGSN---GEGNGQFNAPTGVAVDSNGNIIVAD-WGNSRIQVFDGSGSFLSYINTSADPLyG-- 439
Cdd:cd14958    97 HQVFKFDPEGKllPLLTLGERgepGSDQTHFCKPTDVAVAPDGDIFVADgYCNSRIVKFSPDGKLLKSWGEPGSGP-Gqf 175

                         170       180
                  ....*....|....*....|....*...
gi 1039765474 440 --PQGLALTSDGHVVVADSGNH---CFK 462
Cdd:cd14958   176 nlPHSIALDEDGRVYVADRENGriqVFD 203
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 371-459 3.53e-18

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 84.52  E-value: 3.53e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 371 KVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSYINTSADP---LYGPQGLALTS 447
Cdd:cd14954     1 RDYRAKGRPLLSFGKEGSKDGELCRPWGVAVDKDGRIIVADRSNNRVQVFDPDGKFLRKFGSYGSRdgqFDRPAGVAVNS 80

                          90
                  ....*....|..
gi 1039765474 448 DGHVVVADSGNH 459
Cdd:cd14954    81 RGRIIVADKDNH 92
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 382-464 4.46e-18

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 83.87  E-value: 4.46e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 382 KFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSYINT---SADPLYGPQGLALTSDGHVVVADSGN 458
Cdd:cd14956     1 SWGGRGSGPGQFKDPRGIAVDADDNVYVADARNGRIQVFDKDGTFLRRFGTtgdGPGQFGRPRGLAVDKDGWLYVADYWG 80


                  ....*.
gi 1039765474 459 HCFKVY 464
Cdd:cd14956    81 DRIQVF 86
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 234-421 1.14e-17

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 83.47  E-value: 1.14e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 234 VQIFSNDGQFKSRFGirgrsPGQLQRPTGVAVHPSGDIIIADYDNKWVSIFSNDGKFKTKIGSGKLMG----------PK 303
Cdd:cd14958    57 ILVFDPDGGFLRSWG-----AGLFYMPHGLTIDPDGNIWVTDVGLHQVFKFDPEGKLLPLLTLGERGEpgsdqthfckPT 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 304 GVSVDRNGHIIVVD---NKacCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAVNSNNEIIITDFHNHSVKVFNQEGEF- 379
Cdd:cd14958   132 DVAVAPDGDIFVADgycNS--RIVKFSPDGKLLKSWGEPGSGPGQFNLPHSIALDEDGRVYVADRENGRIQVFDADGKFl 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 380 -------------------------------------------MLK------FGSNGEGNGQFNAPTGVAVDSNGNIIVA 410
Cdd:cd14958   210 tewtnpelgrpyalaidpdgllyvvdgpprlnrslpvrgfvirIGKglilgrFGPGGKAPGQFQNPHDIAVDSGGDIYVG 289

                         250
                  ....*....|.
gi 1039765474 411 DWGNSRIQVFD 421
Cdd:cd14958   290 ELGPNRVQKFV 300
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 336-460 2.51e-17

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 82.58  E-value: 2.51e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 336 FGSRGNGDR--QFAGPHFAAVNSNNEIIITDFHNHSVKVFNQEGEfMLKFGSNGE-----GNG---QFNAPTGVAVDSNG 405
Cdd:cd14953    10 AGFSGGGGTaaRFNSPSGVAVDAAGNLYVADRGNHRIRKITPDGV-VTTVAGTGTagfadGGGaaaQFNTPSGVAVDAAG 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039765474 406 NIIVADWGNSRIQVFD-----------GSGSFLSYINTSADPLYGPQGLALTSDGHVVVADSGNHC 460
Cdd:cd14953    89 NLYVADTGNHRIRKITpdgvvstlagtGTAGFSDDGGATAAQFNYPTGVAVDAAGNLYVADTGNHR 154
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 216-373 3.05e-17

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 81.93  E-value: 3.05e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 216 VAASTSGKILIAD--SNNQCVQiFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIADYDNKWVSIFSNDGKFKTK 293
Cdd:cd14958   133 VAVAPDGDIFVADgyCNSRIVK-FSPDGKLLKSWGEPGSGPGQFNLPHSIALDEDGRVYVADRENGRIQVFDADGKFLTE 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 294 IGSGKLMGPKGVSVDRNGHIIVVD-------NKACCVFIFQPN-GKIVTRFGSRGNGDRQFAGPHFAAVNSNNEIIITDF 365
Cdd:cd14958   212 WTNPELGRPYALAIDPDGLLYVVDgpprlnrSLPVRGFVIRIGkGLILGRFGPGGKAPGQFQNPHDIAVDSGGDIYVGEL 291


                  ....*...
gi 1039765474 366 HNHSVKVF 373
Cdd:cd14958   292 GPNRVQKF 299
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 195-284 3.53e-17

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 81.44  E-value: 3.53e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 195 DLIFRVGTKGRNKGEFTNLQGVAASTSGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIIIA 274
Cdd:cd14954   196 QFLRFFGSEGSGNGQFKRPRGVAVDDEGNIIVADSGNHRVQVFSPDGEFLCSFGTEGNGEGQFDRPSGVAVTPDGRIVVV 275

                          90
                  ....*....|
gi 1039765474 275 DYDNKWVSIF 284
Cdd:cd14954   276 DRGNHRIQVF 285
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 191-278 1.17e-14

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 73.86  E-value: 1.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 191 PIEDDLIFRVGTKGRNKGEFTNLQGVAASTSGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGD 270
Cdd:cd14956   181 DNDGAFLRKWGGRGTGPGQFNYPYGIAIDPDGNVFVADFGNNRIQKFTADGTFLTSWGSPGTGPGQFKNPWGVVVDADGT 260


                  ....*...
gi 1039765474 271 IIIADYDN 278
Cdd:cd14956   261 VYVADSNN 268
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 210-417 1.99e-12

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 66.85  E-value: 1.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 210 FTNL---QGVAASTSGKILIADS-NNQCVQIfsndgqfksrfgIRGRSP------GQLQRPTGVAVHPSGDIIIADYDNK 279
Cdd:cd14952    48 FTGLyqpQGVAVDAAGTVYVTDFgNNRVLKL------------AAGSTTqtvlpfTGLNDPTGVAVDAAGNVYVADTGNN 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 280 WVsifsndgkFKTKIGSGK--------LMGPKGVSVDRNGHIIVVDnkaccvfifqPNGKIVTRFGSRGNGDRQ--FAG- 348
Cdd:cd14952   116 RV--------LKLAAGSNTqtvlpftgLSNPDGVAVDGAGNVYVTD----------TGNNRVLKLAAGSTTQTVlpFTGl 177

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039765474 349 --PHFAAVNSNNEIIITDFHNHSVkvfnqegefmLKF--GSNGEGNGQF---NAPTGVAVDSNGNIIVADWGNSRI 417
Cdd:cd14952   178 nsPSGVAVDTAGNVYVTDHGNNRV----------LKLaaGSTTPTVLPFtglNGPLGVAVDAAGNVYVADRGNDRV 243
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
304-459 3.71e-09

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 57.01  E-value: 3.71e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 304 GVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPHFAAVNSNNEIIITDFHNHSVKVFNQEGEFMLKF 383
Cdd:COG3391    26 AALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVAT 105

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039765474 384 GSNGEGngqfnaPTGVAVDSNGN-IIVADWGNSRIQVFDG-SGSFLSYINTSAdplyGPQGLALTSDG-HVVVADSGNH 459
Cdd:COG3391   106 IPVGGG------PRGLAVDPDGGrLYVADSGNGRVSVIDTaTGKVVATIPVGA----GPHGIAVDPDGkRLYVANSGSN 174
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 293-466 7.92e-09

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 56.44  E-value: 7.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 293 KIGSGKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNgdrqfaGPHFAAVNSNNEIIITDfHNHSVKV 372
Cdd:COG3386     1 KLADAGFRLGEGPVWDPDGRLYWVDIPGGRIHRYDPDGGAVEVFAEPSG------RPNGLAFDPDGRLLVAD-HGRGLVR 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 373 FN-QEGEFMLKFGSNGEGNGQFNaptGVAVDSNGNIIVAD----WGNSRIQVFDGSGSflsyINTSADPLYGPQGLALTS 447
Cdd:COG3386    74 FDpADGEVTVLADEYGKPLNRPN---DGVVDPDGRLYFTDmgeyLPTGALYRVDPDGS----LRVLADGLTFPNGIAFSP 146

                         170       180
                  ....*....|....*....|
gi 1039765474 448 DG-HVVVADSGNHcfKVYRY 466
Cdd:COG3386   147 DGrTLYVADTGAG--RIYRF 164
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 388-466 2.87e-08

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 54.90  E-value: 2.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 388 EGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSYINTSADPLYG-PQGLALTSDGHVVVADSGNHcfKVYRY 466
Cdd:cd14962     6 RPKEALTRPYGVAADGRGRIYVADTGRGAVFVFDLPNGKVFVIGNAGPNRFVsPIGVAIDANGNLYVSDAELG--KVFVF 83
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 215-427 4.52e-08

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 54.13  E-value: 4.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 215 GVAASTSGKILIADSNNQCVQIFSNDGQFKSRFgirgRSPGQlqRPTGVAVHPSGDIIIADYDNKWVSIFSNDGKFKTKI 294
Cdd:COG3386    12 GPVWDPDGRLYWVDIPGGRIHRYDPDGGAVEVF----AEPSG--RPNGLAFDPDGRLLVADHGRGLVRFDPADGEVTVLA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 295 GSG--KLMGPKGVSVDRNGHIIVVDnkaccVFIFQPNGKIVtRFGSRGNGDRQFAGPHFA---AVNSNNEI-IITDFHNH 368
Cdd:COG3386    86 DEYgkPLNRPNDGVVDPDGRLYFTD-----MGEYLPTGALY-RVDPDGSLRVLADGLTFPngiAFSPDGRTlYVADTGAG 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039765474 369 SVKVF--NQEGEFMLK--FGSNGEGNGqfnAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFL 427
Cdd:COG3386   160 RIYRFdlDADGTLGNRrvFADLPDGPG---GPDGLAVDADGNLWVALWGGGGVVRFDPDGELL 219
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 393-420 1.52e-07

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 47.40  E-value: 1.52e-07
                          10        20
                  ....*....|....*....|....*...
gi 1039765474 393 FNAPTGVAVDSNGNIIVADWGNSRIQVF 420
Cdd:pfam01436   1 FNRPHGVAVDSNGDIYVADSENHRVQVF 28
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
194-421 2.80e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 51.62  E-value: 2.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 194 DDLIFRVGTKGRNKGEFTNLQGVAASTSGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIII 273
Cdd:COG3391     5 SSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 274 ADYDNKWVSIF-SNDGKFKTKIGSGKlmGPKGVSVDRNG-HIIVVDNKACCVFIF-QPNGKIVTRFGSrgngdrqFAGPH 350
Cdd:COG3391    85 ANSGSGRVSVIdLATGKVVATIPVGG--GPRGLAVDPDGgRLYVADSGNGRVSVIdTATGKVVATIPV-------GAGPH 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 351 FAAVNS-NNEIIITDFHNHSVKVF-----NQEGEFM--LKFGSNgegngqfnaPTGVAVDSNGNIIV--------ADWGN 414
Cdd:COG3391   156 GIAVDPdGKRLYVANSGSNTVSVIvsvidTATGKVVatIPVGGG---------PVGVAVSPDGRRLYvanrgsntSNGGS 226


                  ....*..
gi 1039765474 415 SRIQVFD 421
Cdd:COG3391   227 NTVSVID 233
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 196-284 3.10e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 51.52  E-value: 3.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 196 LIFRVGTKGRNKGEFTNLQGVAASTSGKILIADSNNQCVQIFSNDGQFKSR----------------------------- 246
Cdd:cd14963   133 LLLEFGKPGSEPGELSYPNGIAVDEDGNIYVADSGNGRIQVFDKNGKFIKElngspdgksgfvnprgiavdpdgnlyvvd 212

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039765474 247 ------------------FGIRGRSPGQLQRPTGVAVHPSGDIIIADYDNKWVSIF 284
Cdd:cd14963   213 nlshrvyvfdeqgkelftFGGRGKDDGQFNLPNGLFIDDDGRLYVTDRENNRVAVY 268
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 253-466 3.70e-07

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 51.43  E-value: 3.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 253 SPGQLQRPTGVAVHPSGDIIIADYDNKWVSIFSNDGKFKTKIGSGKlMGPKGVSVDRNGHIIVVDNKACcVFIFQPNGKI 332
Cdd:COG3386     3 ADAGFRLGEGPVWDPDGRLYWVDIPGGRIHRYDPDGGAVEVFAEPS-GRPNGLAFDPDGRLLVADHGRG-LVRFDPADGE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 333 VTRFGSRGngDRQFAGPHFAAVNSNNEIIITDFHNH----SVKVFNQEGEFMLKFGSngegngqFNAPTGVAVDSNGNI- 407
Cdd:COG3386    81 VTVLADEY--GKPLNRPNDGVVDPDGRLYFTDMGEYlptgALYRVDPDGSLRVLADG-------LTFPNGIAFSPDGRTl 151

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039765474 408 IVADWGNSRIQVFD--GSGSfLS----YINTSADPlYGPQGLALTSDGHVVVADSGNHCfkVYRY 466
Cdd:COG3386   152 YVADTGAGRIYRFDldADGT-LGnrrvFADLPDGP-GGPDGLAVDADGNLWVALWGGGG--VVRF 212
DUF5128 pfam17170
6-bladed beta-propeller; This family is a 6-bladed beta-propeller structure of unknown ...
 356-466 2.99e-06

6-bladed beta-propeller; This family is a 6-bladed beta-propeller structure of unknown function. There is a highly conserved FDxxG motif which might be important.


Pssm-ID: 407298 [Multi-domain]  Cd Length: 321  Bit Score: 48.86  E-value: 2.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 356 SNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGNGQFNAPTGVAVD-SNGNIIVADWGNSRIQVFD-GSGSFLSYINTS 433
Cdd:pfam17170  52 VDDRIFVFDSNTNNLFVFDKKGKFVRQIGAQGNGPGEYLQINDFIIDkSNNSIYILDFMQNKILTYDlDGYSFIGEINLD 131

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1039765474 434 ADP-----------LYGPQGLA--LTSDGHVVVADS-GNHCFKVYRY 466
Cdd:pfam17170 132 LLPsdccqldkgklAFDSSGFDdgKRSGFYLVITDElGNIISGFFPA 178
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 437-464 4.03e-06

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 43.16  E-value: 4.03e-06
                          10        20
                  ....*....|....*....|....*...
gi 1039765474 437 LYGPQGLALTSDGHVVVADSGNHCFKVY 464
Cdd:pfam01436   1 FNRPHGVAVDSNGDIYVADSENHRVQVF 28
DUF5128 pfam17170
6-bladed beta-propeller; This family is a 6-bladed beta-propeller structure of unknown ...
 310-438 4.38e-06

6-bladed beta-propeller; This family is a 6-bladed beta-propeller structure of unknown function. There is a highly conserved FDxxG motif which might be important.


Pssm-ID: 407298 [Multi-domain]  Cd Length: 321  Bit Score: 48.48  E-value: 4.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 310 NGHIIVVDNKACCVFIFQPNGKIVTRFGSRGNGDRQFAGPH-FAAVNSNNEIIITDFHNHSVKVFNQEG-EFM------- 380
Cdd:pfam17170  53 DDRIFVFDSNTNNLFVFDKKGKFVRQIGAQGNGPGEYLQINdFIIDKSNNSIYILDFMQNKILTYDLDGySFIgeinldl 132

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 381 ------------LKFGSNGEGNGQFNAPTGVAVDSNGNIIVADWGNSRiqvfdgsgsFLSYINTSADPLY 438
Cdd:pfam17170 133 lpsdccqldkgkLAFDSSGFDDGKRSGFYLVITDELGNIISGFFPAEF---------TLGILFNSSVPFY 193
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 346-373 6.15e-06

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 42.77  E-value: 6.15e-06
                          10        20
                  ....*....|....*....|....*...
gi 1039765474 346 FAGPHFAAVNSNNEIIITDFHNHSVKVF 373
Cdd:pfam01436   1 FNRPHGVAVDSNGDIYVADSENHRVQVF 28
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 205-465 2.08e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.17  E-value: 2.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 205 RNKGEFTNLQGVAASTSGKILIADSNNQCVQIFS-NDGQFKSRFGirgrspGQLQRPTGVAVHPSGDIIIADYDNKWVSI 283
Cdd:cd00200    46 TLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDlETGECVRTLT------GHTSYVSSVAFSPDGRILSSSSRDKTIKV 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 284 FS-NDGKFKTKIgSGKLMGPKGVSVDRNGHIIVVDNKACCVFIFQP-NGKIVTRFGSrgngdrqfagpHFAAVNS----- 356
Cdd:cd00200   120 WDvETGKCLTTL-RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLrTGKCVATLTG-----------HTGEVNSvafsp 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 357 NNEIIITDFHNHSVKVFNQEGEFMLKfgsngEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDG-SGSFLSyintsad 435
Cdd:cd00200   188 DGEKLLSSSSDGTIKLWDLSTGKCLG-----TLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLrTGECVQ------- 255

                         250       260       270
                  ....*....|....*....|....*....|....
gi 1039765474 436 PLYGPQG----LALTSDGHVVVADSGNHCFKVYR 465
Cdd:cd00200   256 TLSGHTNsvtsLAWSPDGKRLASGSADGTIRIWD 289
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
 396-459 2.54e-05

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 46.03  E-value: 2.54e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039765474 396 PTGVAVDSNGNIIVADWGNSRIQVFD----------GSGSFLSYINTSAdpLYGPQGLALTSDGHVVVADSGNH 459
Cdd:cd14951   198 PLGVAALPDGSVYVADTYNHKIKRVDpatgevstlaGTGKAGYKDLEAQ--FSEPSGLVVDGDGRLYVADTNNH 269
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
 353-421 7.21e-05

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 44.88  E-value: 7.21e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039765474 353 AVNSNNEIIITDFHNHSVKVFN---QEGEFMLKFGSNGEGN--GQFNAPTGVAVDSNGNIIVADWGNSRIQVFD 421
Cdd:cd14951   202 AALPDGSVYVADTYNHKIKRVDpatGEVSTLAGTGKAGYKDleAQFSEPSGLVVDGDGRLYVADTNNHRIRRLD 275
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 257-284 7.79e-05

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 39.69  E-value: 7.79e-05
                          10        20
                  ....*....|....*....|....*...
gi 1039765474 257 LQRPTGVAVHPSGDIIIADYDNKWVSIF 284
Cdd:pfam01436   1 FNRPHGVAVDSNGDIYVADSENHRVQVF 28
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
 235-421 1.04e-04

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 44.84  E-value: 1.04e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474  235 QIFSNDGQFKSRFGIRGRSPGQLQrPTGVAVHPSGD-IIIADYDNKwvSIFSNDgkFKTKiGSGKLMGpkgvsvdrnGHI 313
Cdd:PLN02919   718 RVFSGDGYERNLNGSSGTSTSFAQ-PSGISLSPDLKeLYIADSESS--SIRALD--LKTG-GSRLLAG---------GDP 782

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474  314 IVVDNkaccvfIFQpngkivtrFGSR-GNGDR-QFAGPHFAAVNSNNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEGN- 390
Cdd:PLN02919   783 TFSDN------LFK--------FGDHdGVGSEvLLQHPLGVLCAKDGQIYVADSYNHKIKKLDPATKRVTTLAGTGKAGf 848

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1039765474  391 -------GQFNAPTGVAVDSNGNIIVADWGNSRIQVFD 421
Cdd:PLN02919   849 kdgkalkAQLSEPAGLALGENGRLFVADTNNSLIRYLD 886
DUF5128 pfam17170
6-bladed beta-propeller; This family is a 6-bladed beta-propeller structure of unknown ...
 222-404 1.38e-04

6-bladed beta-propeller; This family is a 6-bladed beta-propeller structure of unknown function. There is a highly conserved FDxxG motif which might be important.


Pssm-ID: 407298 [Multi-domain]  Cd Length: 321  Bit Score: 43.85  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 222 GKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTgvavhpsgDIIIADYDNkwvSIFSNDgKFKTKIGSGKLMG 301
Cdd:pfam17170  54 DRIFVFDSNTNNLFVFDKKGKFVRQIGAQGNGPGEYLQIN--------DFIIDKSNN---SIYILD-FMQNKILTYDLDG 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 302 PKGVSVDRnghiivVDNKACCVFIFQPNGKIvtrFGSRGNGDRQFAGPHFAAVNSNNEIIITDFHNhsvkvfnqegEFML 381
Cdd:pfam17170 122 YSFIGEIN------LDLLPSDCCQLDKGKLA---FDSSGFDDGKRSGFYLVITDELGNIISGFFPA----------EFTL 182

                         170       180
                  ....*....|....*....|...
gi 1039765474 382 KFGSNgegngqfNAPTGVAVDSN 404
Cdd:pfam17170 183 GILFN-------SSVPFYEYGDN 198
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
260-463 2.61e-04

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 42.97  E-value: 2.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 260 PTGVAVHPSGDIIIA--DYDNKWVSIFS---NDGKFkTKIGSGKLMG--PKGVSVDRNGHIIVVDN---KACCVFIFQPN 329
Cdd:COG2706    47 PSFLALSPDGRFLYAvnEVDDGGVSAFRidpADGTL-TLLNTVSSGGasPCHLSVDPDGRFLFVANyggGSVSVFPIDAD 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 330 GKI------VTRFGSRGNGDRQ-FAGPHFAAVN-SNNEIIITDFHNHSVKVFN---------QEGEFMLKFGSngegngq 392
Cdd:COG2706   126 GSLgepvqvIQHEGSGPNPERQeGPHAHSVVFDpDGRFLYVPDLGTDRIYVYRldpatgklpEPPEVSLPPGS------- 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 393 fnAPTGVAVDSNGNII-VADWGNSRIQVF-----DGSGSFLSYINTSADPLYG---PQGLALTSDG-HVVVADSGNH--- 459
Cdd:COG2706   199 --GPRHLAFHPNGRFAyVINELDSTVSVYaydaaTGTLTLIQTVSTLPEDFTGenwAADIHISPDGrFLYVSNRGHNsia 276


                  ....
gi 1039765474 460 CFKV 463
Cdd:COG2706   277 VFAI 280
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
 210-467 4.55e-04

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 42.92  E-value: 4.55e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474  210 FTNLQGVAASTSGKIL-IADSNN----------QCVQIFSNDGQFKSRFgiRGRSPGQLQ---RPTGVAVHPSGDII--- 272
Cdd:PLN02919   623 FNRPQGLAYNAKKNLLyVADTENhalreidfvnETVRTLAGNGTKGSDY--QGGKKGTSQvlnSPWDVCFEPVNEKVyia 700

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474  273 ------IADYD--NKWVSIFSNDGKFKTKIGSG----KLMGPKGVSVDRN-GHIIVVDNKACCVfifqpngkivTRFGSR 339
Cdd:PLN02919   701 magqhqIWEYNisDGVTRVFSGDGYERNLNGSSgtstSFAQPSGISLSPDlKELYIADSESSSI----------RALDLK 770

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474  340 GNGDRQFAG--PHFaavnSNNeiiitdfhnhsvkvfnqegefMLKFGSN-GEG-NGQFNAPTGVAVDSNGNIIVADWGNS 415
Cdd:PLN02919   771 TGGSRLLAGgdPTF----SDN---------------------LFKFGDHdGVGsEVLLQHPLGVLCAKDGQIYVADSYNH 825

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039765474  416 RIQVFDGSGSFLSYINTS-----------ADPLYGPQGLALTSDGHVVVADSGNhcfKVYRYL 467
Cdd:PLN02919   826 KIKKLDPATKRVTTLAGTgkagfkdgkalKAQLSEPAGLALGENGRLFVADTNN---SLIRYL 885
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
 257-317 5.27e-04

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 42.18  E-value: 5.27e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039765474 257 LQRPTGVAVHPSGDIIIADYDN----------KWVSIFSNDGKFKTKIGSGKLMGPKGVSVDRNGHIIVVD 317
Cdd:cd14951   195 LQHPLGVAALPDGSVYVADTYNhkikrvdpatGEVSTLAGTGKAGYKDLEAQFSEPSGLVVDGDGRLYVAD 265
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 210-237 6.36e-04

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 37.00  E-value: 6.36e-04
                          10        20
                  ....*....|....*....|....*...
gi 1039765474 210 FTNLQGVAASTSGKILIADSNNQCVQIF 237
Cdd:pfam01436   1 FNRPHGVAVDSNGDIYVADSENHRVQVF 28
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
 357-466 1.09e-03

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 41.76  E-value: 1.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474  357 NNEIIITDFHNHSVKVFNQEGEFMLKFGSNGE--------GNGQFNAPTGVAVDSNGNII-VA----------DWGNSRI 417
Cdd:PLN02919   579 NNRLFISDSNHNRIVVTDLDGNFIVQIGSTGEeglrdgsfEDATFNRPQGLAYNAKKNLLyVAdtenhalreiDFVNETV 658

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039765474  418 QVFDGSGS----FLSYINTSADPLYGPQGLALTS-DGHVVVADSGNHcfKVYRY 466
Cdd:PLN02919   659 RTLAGNGTkgsdYQGGKKGTSQVLNSPWDVCFEPvNEKVYIAMAGQH--QIWEY 710
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 395-424 1.20e-03

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 40.32  E-value: 1.20e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1039765474 395 APTGVAVDSNGNIIVADWGNSRIQVFDGSG 424
Cdd:pfam08450 185 RPDGMAVDAEGNVWVARWGGGKVVRFDPDG 214
ScyE_fam NF033206
ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin ...
 393-454 1.28e-03

ScyD/ScyE family protein; This family includes ScyE, a protein involved in scytomenin biosynthesis and export, and its paralog ScyD. Some members of the family contain a C-terminal PEP-CTERM domain that predictions anchoring to the outer membrane.


Pssm-ID: 467996 [Multi-domain]  Cd Length: 330  Bit Score: 40.72  E-value: 1.28e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039765474 393 FNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSfLSYI------NTSADPLYGPQGLALTSDGHVVVA 454
Cdd:NF033206  249 FTGLTDLAFDPDGNLYVLELAGGGLLKGDPTGS-LIRIapdgtrTTLLDGLELPTGLAVGPDGTLYVT 315
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 193-237 1.57e-03

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 40.22  E-value: 1.57e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1039765474 193 EDDLIFRVGTKGRNKGEFTNLQGVAASTSGKILIADSNNQCVQIF 237
Cdd:cd14954   241 DGEFLCSFGTEGNGEGQFDRPSGVAVTPDGRIVVVDRGNHRIQVF 285
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 299-326 1.91e-03

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 35.46  E-value: 1.91e-03
                          10        20
                  ....*....|....*....|....*...
gi 1039765474 299 LMGPKGVSVDRNGHIIVVDNKACCVFIF 326
Cdd:pfam01436   1 FNRPHGVAVDSNGDIYVADSENHRVQVF 28
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 257-336 8.70e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 37.95  E-value: 8.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039765474 257 LQRPTGVAVHPSGDI-IIADYDNKWVSIF--SNDGK-------FKTKIGSGklmGPKGVSVDRNGHIIVVDNKACCVFIF 326
Cdd:COG3386   136 LTFPNGIAFSPDGRTlYVADTGAGRIYRFdlDADGTlgnrrvfADLPDGPG---GPDGLAVDADGNLWVALWGGGGVVRF 212

                          90
                  ....*....|
gi 1039765474 327 QPNGKIVTRF 336
Cdd:COG3386   213 DPDGELLGRI 222
NHL-2_like cd14951
NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL ...
 440-459 8.76e-03

NHL repeat domain of NHL repeat-containing protein 2 and similar proteins; NHL repeat-containing protein 2 (NHLRC2) and related bacterial proteins; members of this eukaryotic and bacterial family are uncharacterized, the NHL repeat domain is found C-terminally of a thioredoxin domain. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271321 [Multi-domain]  Cd Length: 334  Bit Score: 38.33  E-value: 8.76e-03
                          10        20
                  ....*....|....*....|
gi 1039765474 440 PQGLALTSDGHVVVADSGNH 459
Cdd:cd14951    21 PQGLALLPGNILYVADTENH 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH