|
Name |
Accession |
Description |
Interval |
E-value |
| TIR |
pfam01582 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
708-858 |
3.47e-28 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 111.30 E-value: 3.47e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 708 YDAYFCFS-SKDFEWAQNALLKHLDahyssRNRLRLCFEERDFIPGENHISNIQAAVWGSRKTVCLVSRHFLKDGWCLEA 786
Cdd:pfam01582 1 YDVFLSFRgSDTREWFVSHLLKELK-----QKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 787 FRYAQSRSLsDLKSILIVVVVGSLSQYQL-------MRHETIRGFLQKQQYLRWPEDL------------QDVGWFLDKL 847
Cdd:pfam01582 76 LVKILECAL-DLGQKVIPIFYEVDPSDVRkqtgsfgKAFKKHKKVLTEEKVLKWRGALnevaniwhsksvSDESKFWKKI 154
|
170
....*....|.
gi 1039729551 848 SGCILKEEKGK 858
Cdd:pfam01582 155 AYDISNKLNGT 165
|
|
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
707-842 |
3.31e-26 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 104.71 E-value: 3.31e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 707 RYDAYFCFSSKDfeWAQNALLKHLdahYSSRNRLRLCFEERDFIPGENHISNIQAAVWGSRKTVCLVSRHFLKDGWCLEA 786
Cdd:smart00255 1 EYDVFISYSGKE--DVRNEFLSHL---LEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1039729551 787 FRYAQSRSLSDLKSILIVVVVGSLSQYQLMRHETIRGFLQKqQYLRWPEDLQDVGW 842
Cdd:smart00255 76 LVAALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKK-NYLKWPEDEKEQFW 130
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
322-596 |
4.62e-17 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 84.60 E-value: 4.62e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 322 LFGTLKDLKMLNLAFNKINKIGENAFYGLDSLQVLNLSYNLLGELYNSNFYGLPRVAYVDLQRNHIGIIQDQTFRLLKTL 401
Cdd:COG4886 19 ELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 402 QTLDLRDNalKAIGFIPSIQMVLLGGNKLVHLPHI--HFTA-NFLELSENRLENLSDlyFLLRVPQLQFLILNQNRLSSC 478
Cdd:COG4886 99 TELDLSGN--EELSNLTNLESLDLSGNQLTDLPEElaNLTNlKELDLSNNQLTDLPE--PLGNLTNLKSLDLSNNQLTDL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 479 KAAhtPSENPSLEQLFLTENMLQ-LAwetglcwDVFQGLSRLQILYLSNNYLNFLPPGIFNdLVALRMLSLSANKLTVLS 557
Cdd:COG4886 175 PEE--LGNLTNLKELDLSNNQITdLP-------EPLGNLTNLEELDLSGNQLTDLPEPLAN-LTNLETLDLSNNQLTDLP 244
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 1039729551 558 P-GSLPaNLEILDISRNQLFS-PDPALFSSLRVLDITHNEF 596
Cdd:COG4886 245 ElGNLT-NLEELDLSNNQLTDlPPLANLTNLKTLDLSNNQL 284
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
397-597 |
3.78e-11 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 67.03 E-value: 3.78e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 397 LLKTLQTLDLRDNALKAI-GFIP-SIQMVLLGGNKLVHLP-HIHFTANFLELSENRLENLSDlyfllRVPQ-LQFLILNQ 472
Cdd:PRK15370 218 LQGNIKTLYANSNQLTSIpATLPdTIQEMELSINRITELPeRLPSALQSLDLFHNKISCLPE-----NLPEeLRYLSVYD 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 473 NRLSSCkAAHTPSenpSLEQLFLTENMLQLAWETglcwdvfqgLS-RLQILYLSNNYLNFLPPGIfndLVALRMLSLSAN 551
Cdd:PRK15370 293 NSIRTL-PAHLPS---GITHLNVQSNSLTALPET---------LPpGLKTLEAGENALTSLPASL---PPELQVLDVSKN 356
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1039729551 552 KLTVLsPGSLPANLEILDISRNQLFSPDPALFSSLRVLDITHNEFV 597
Cdd:PRK15370 357 QITVL-PETLPPTITTLDVSRNALTNLPENLPAALQIMQASRNNLV 401
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
308-363 |
6.95e-11 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 58.30 E-value: 6.95e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1039729551 308 LDLSHGFIFSLNPRLFGTLKDLKMLNLAFNKINKIGENAFYGLDSLQVLNLSYNLL 363
Cdd:pfam13855 6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
99-146 |
1.48e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 49.06 E-value: 1.48e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 1039729551 99 LTIGPGAFRNLPNLRILDLGQSQIEVLNRDAFQGLPHLLELRLFSCGL 146
Cdd:pfam13855 14 TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
98-333 |
1.60e-07 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 54.55 E-value: 1.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 98 NLTIGPGAFRNLPNLRILDLGQSQIEVLNrDAFQGLPHLLELRLFSCGLSSAvlsdGYFRNLYSLARLDLSGNQIHSLrl 177
Cdd:COG4886 193 QITDLPEPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDL----PELGNLTNLEELDLSNNQLTDL-- 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 178 hSSFRELNSLSDVNFAFNQIFTICedelepLQGKTLSFFGLKLTKLFSRVSVGWETCRNPFRGVRLETLDLSENGWTVDI 257
Cdd:COG4886 266 -PPLANLTNLKTLDLSNNQLTDLK------LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLT 338
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039729551 258 TRNFSNIIQGSQISSLILKHHIMGPGFGFQNIRDPDQSTFASLARSSVLQLDLSHGFIFSLNPRLFGTLKDLKMLN 333
Cdd:COG4886 339 TLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
353-595 |
5.48e-07 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 52.36 E-value: 5.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 353 LQVLNLSYNLLGELynsnfyGLPRVAYVdlqrnhigiIQDQtfrllKTLQTLDLRDNALKAIG-FIPSIQMVLLGGNKLV 431
Cdd:cd00116 25 LQVLRLEGNTLGEE------AAKALASA---------LRPQ-----PSLKELCLSLNETGRIPrGLQSLLQGLTKGCGLQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 432 HLPhiHFTANFLELSENRLENlsdlyfLLRVPQLQFLILNQNRLSSCKAAHT----PSENPSLEQLFLTENMLqlawETG 507
Cdd:cd00116 85 ELD--LSDNALGPDGCGVLES------LLRSSSLQELKLNNNGLGDRGLRLLakglKDLPPALEKLVLGRNRL----EGA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 508 LCWD---VFQGLSRLQILYLSNNylNFLPPGI------FNDLVALRMLSLSANKLTVLSPGSL------PANLEILDISR 572
Cdd:cd00116 153 SCEAlakALRANRDLKELNLANN--GIGDAGIralaegLKANCNLEVLDLNNNGLTDEGASALaetlasLKSLEVLNLGD 230
|
250 260 270
....*....|....*....|....*....|.
gi 1039729551 573 NQLFSPD--------PALFSSLRVLDITHNE 595
Cdd:cd00116 231 NNLTDAGaaalasalLSPNISLLTLSLSCND 261
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
569-647 |
3.37e-05 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 47.77 E-value: 3.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 569 DISRNQLFSPDPALFS---SLRVLDITHNEFVCNCELSTFISWLNQTNVTLFgSPADVYCMYPNSLLGGSLYNIS--TED 643
Cdd:TIGR00864 1 DISNNKISTIEEGICAnlcNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVR-QPEAALCAGPGALAGQPLLGIPllDSG 79
|
....
gi 1039729551 644 CDEE 647
Cdd:TIGR00864 80 CDEE 83
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
106-195 |
1.30e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 41.31 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 106 FRNLPNLRILDLGQSQIEVLNrdAFQGLPHLLELRL------------FSCGLSSAVL--------------SDGYFRNL 159
Cdd:cd21340 64 LENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIenqrlppgekltFDPRSLAALSnslrvlnisgnnidSLEPLAPL 141
|
90 100 110
....*....|....*....|....*....|....*..
gi 1039729551 160 YSLARLDLSGNQIHSLR-LHSSFRELNSLSDVNFAFN 195
Cdd:cd21340 142 RNLEQLDASNNQISDLEeLLDLLSSWPSLRELDLTGN 178
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
594-645 |
9.08e-03 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 35.10 E-value: 9.08e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1039729551 594 NEFVCNCELSTFISWLNQTNVtlFGSPADVYCMYPNSLLGGSL-YNISTEDCD 645
Cdd:smart00082 1 NPFICDCELRWLLRWLQANEH--LQDPVDLRCASPSSLRGPLLeLLHSEFKCP 51
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| TIR |
pfam01582 |
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ... |
708-858 |
3.47e-28 |
|
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.
Pssm-ID: 396246 [Multi-domain] Cd Length: 165 Bit Score: 111.30 E-value: 3.47e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 708 YDAYFCFS-SKDFEWAQNALLKHLDahyssRNRLRLCFEERDFIPGENHISNIQAAVWGSRKTVCLVSRHFLKDGWCLEA 786
Cdd:pfam01582 1 YDVFLSFRgSDTREWFVSHLLKELK-----QKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 787 FRYAQSRSLsDLKSILIVVVVGSLSQYQL-------MRHETIRGFLQKQQYLRWPEDL------------QDVGWFLDKL 847
Cdd:pfam01582 76 LVKILECAL-DLGQKVIPIFYEVDPSDVRkqtgsfgKAFKKHKKVLTEEKVLKWRGALnevaniwhsksvSDESKFWKKI 154
|
170
....*....|.
gi 1039729551 848 SGCILKEEKGK 858
Cdd:pfam01582 155 AYDISNKLNGT 165
|
|
| TIR |
smart00255 |
Toll - interleukin 1 - resistance; |
707-842 |
3.31e-26 |
|
Toll - interleukin 1 - resistance;
Pssm-ID: 214587 [Multi-domain] Cd Length: 140 Bit Score: 104.71 E-value: 3.31e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 707 RYDAYFCFSSKDfeWAQNALLKHLdahYSSRNRLRLCFEERDFIPGENHISNIQAAVWGSRKTVCLVSRHFLKDGWCLEA 786
Cdd:smart00255 1 EYDVFISYSGKE--DVRNEFLSHL---LEKLRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDE 75
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1039729551 787 FRYAQSRSLSDLKSILIVVVVGSLSQYQLMRHETIRGFLQKqQYLRWPEDLQDVGW 842
Cdd:smart00255 76 LVAALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKK-NYLKWPEDEKEQFW 130
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
322-596 |
4.62e-17 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 84.60 E-value: 4.62e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 322 LFGTLKDLKMLNLAFNKINKIGENAFYGLDSLQVLNLSYNLLGELYNSNFYGLPRVAYVDLQRNHIGIIQDQTFRLLKTL 401
Cdd:COG4886 19 ELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 402 QTLDLRDNalKAIGFIPSIQMVLLGGNKLVHLPHI--HFTA-NFLELSENRLENLSDlyFLLRVPQLQFLILNQNRLSSC 478
Cdd:COG4886 99 TELDLSGN--EELSNLTNLESLDLSGNQLTDLPEElaNLTNlKELDLSNNQLTDLPE--PLGNLTNLKSLDLSNNQLTDL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 479 KAAhtPSENPSLEQLFLTENMLQ-LAwetglcwDVFQGLSRLQILYLSNNYLNFLPPGIFNdLVALRMLSLSANKLTVLS 557
Cdd:COG4886 175 PEE--LGNLTNLKELDLSNNQITdLP-------EPLGNLTNLEELDLSGNQLTDLPEPLAN-LTNLETLDLSNNQLTDLP 244
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 1039729551 558 P-GSLPaNLEILDISRNQLFS-PDPALFSSLRVLDITHNEF 596
Cdd:COG4886 245 ElGNLT-NLEELDLSNNQLTDlPPLANLTNLKTLDLSNNQL 284
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
319-674 |
3.32e-15 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 78.82 E-value: 3.32e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 319 NPRLFGTLKDLKMLNLAFNKINKIGEnAFYGLDSLQVLNLSYNLLGELyNSNFYGLPRVAYVDLQRNHIGIIqDQTFRLL 398
Cdd:COG4886 105 GNEELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDL-PEELGNL 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 399 KTLQTLDLRDNALKAIGfipsiqmvllggNKLVHLPHIhftaNFLELSENRLENLSDlyFLLRVPQLQFLILNQNRLSSC 478
Cdd:COG4886 182 TNLKELDLSNNQITDLP------------EPLGNLTNL----EELDLSGNQLTDLPE--PLANLTNLETLDLSNNQLTDL 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 479 kaahtpsenPSLEQLfltenmlqlawetglcwdvfqglSRLQILYLSNNYLNFLPPGIfnDLVALRMLSLSANKLTVLSP 558
Cdd:COG4886 244 ---------PELGNL-----------------------TNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKL 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 559 GSLPANLEILDISRNQLFSPDPALFSSLRVLDITHNEFVCNCELSTFISWLNQTNVTLFGSPADVYCMYPNSLLGGSLYN 638
Cdd:COG4886 290 KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTL 369
|
330 340 350
....*....|....*....|....*....|....*.
gi 1039729551 639 ISTEDCDEEEAMRSLKFSLFILCTVTLTLFLVITLV 674
Cdd:COG4886 370 GLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTL 405
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
260-575 |
7.63e-15 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 77.67 E-value: 7.63e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 260 NFSNIIQGSQISSLILKHHIMGPGFGFQNIRDPDQSTFASLARSSVLQLDLSHGFIFSLNPRLFGTLKDLKMLNLAFNKI 339
Cdd:COG4886 5 LLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 340 NKIGENAFYGLDSLQVLNLSYNllgelynSNFYGLPRVAYVDLQRNHIGIIqDQTFRLLKTLQTLDLRDNALKAIGfips 419
Cdd:COG4886 85 LLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLP---- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 420 iqmvllggNKLVHLPHIhftaNFLELSENRLENLSDlyFLLRVPQLQFLILNQNRLSSckAAHTPSENPSLEQLFLTENM 499
Cdd:COG4886 153 --------EPLGNLTNL----KSLDLSNNQLTDLPE--ELGNLTNLKELDLSNNQITD--LPEPLGNLTNLEELDLSGNQ 216
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039729551 500 LQ-LAWEtglcwdvFQGLSRLQILYLSNNYLNFLPpgIFNDLVALRMLSLSANKLTVLSPGSLPANLEILDISRNQL 575
Cdd:COG4886 217 LTdLPEP-------LANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
397-597 |
3.78e-11 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 67.03 E-value: 3.78e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 397 LLKTLQTLDLRDNALKAI-GFIP-SIQMVLLGGNKLVHLP-HIHFTANFLELSENRLENLSDlyfllRVPQ-LQFLILNQ 472
Cdd:PRK15370 218 LQGNIKTLYANSNQLTSIpATLPdTIQEMELSINRITELPeRLPSALQSLDLFHNKISCLPE-----NLPEeLRYLSVYD 292
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 473 NRLSSCkAAHTPSenpSLEQLFLTENMLQLAWETglcwdvfqgLS-RLQILYLSNNYLNFLPPGIfndLVALRMLSLSAN 551
Cdd:PRK15370 293 NSIRTL-PAHLPS---GITHLNVQSNSLTALPET---------LPpGLKTLEAGENALTSLPASL---PPELQVLDVSKN 356
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1039729551 552 KLTVLsPGSLPANLEILDISRNQLFSPDPALFSSLRVLDITHNEFV 597
Cdd:PRK15370 357 QITVL-PETLPPTITTLDVSRNALTNLPENLPAALQIMQASRNNLV 401
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
308-363 |
6.95e-11 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 58.30 E-value: 6.95e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1039729551 308 LDLSHGFIFSLNPRLFGTLKDLKMLNLAFNKINKIGENAFYGLDSLQVLNLSYNLL 363
Cdd:pfam13855 6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
517-575 |
1.39e-10 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 57.53 E-value: 1.39e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039729551 517 SRLQILYLSNNYLNFLPPGIFNDLVALRMLSLSANKLTVLSPGSL--PANLEILDISRNQL 575
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
51-493 |
3.00e-10 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 63.41 E-value: 3.00e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 51 NLTQIPWILNTTTERLLLSFNYISMVVATSFPLLERLQLLELGTQYANLTIGPGAFRNLPNLRILDLGqsqievlNRDAF 130
Cdd:COG4886 37 LLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLS-------GNEEL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 131 QGLPHLLELRLFSCGLSSAvlsDGYFRNLYSLARLDLSGNQIHSLrlHSSFRELNSLSDVNFAFNQIFTIcEDELEPLQG 210
Cdd:COG4886 110 SNLTNLESLDLSGNQLTDL---PEELANLTNLKELDLSNNQLTDL--PEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTN 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 211 -KTLSFFGLKLTKLFSRVSvgweTCRNpfrgvrLETLDLSENgwtvditrnfsniiqgsQISSLilkhhimgpgfgfqni 289
Cdd:COG4886 184 lKELDLSNNQITDLPEPLG----NLTN------LEELDLSGN-----------------QLTDL---------------- 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 290 rdpdqstFASLARSSVLQ-LDLSHGFIFSLnPRLfGTLKDLKMLNLAFNKINKIGENAfyGLDSLQVLNLSYNLLGELYN 368
Cdd:COG4886 221 -------PEPLANLTNLEtLDLSNNQLTDL-PEL-GNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKL 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 369 SNFYGLPRVAyvDLQRNHIGIIQDQTFRLLKTLQTLDLRDNALKAIGFIPSIQMVLLGGNKLVHLPHIHFTANFLELSEN 448
Cdd:COG4886 290 KELELLLGLN--SLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLL 367
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 1039729551 449 RLENLSDLYFLLRVPQLQFLILNQNRLSSCKAAHTPSENPSLEQL 493
Cdd:COG4886 368 TLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVN 412
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
329-387 |
6.92e-10 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 55.61 E-value: 6.92e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1039729551 329 LKMLNLAFNKINKIGENAFYGLDSLQVLNLSYNLLGELYNSNFYGLPRVAYVDLQRNHI 387
Cdd:pfam13855 3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
488-553 |
1.69e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 54.45 E-value: 1.69e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039729551 488 PSLEQLFLTENMLqlaweTGLCWDVFQGLSRLQILYLSNNYLNFLPPGIFNDLVALRMLSLSANKL 553
Cdd:pfam13855 1 PNLRSLDLSNNRL-----TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| TIR_2 |
pfam13676 |
TIR domain; This is a family of Toll-like receptors. |
711-807 |
3.36e-09 |
|
TIR domain; This is a family of Toll-like receptors.
Pssm-ID: 463954 [Multi-domain] Cd Length: 118 Bit Score: 55.40 E-value: 3.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 711 YFCFSSKDFEWAQnALLKHLDAHyssrnRLRLCFEERDFIPGENHISNIQAAVWGSRKTVCLVSRHFLKDGWCLEAFRYA 790
Cdd:pfam13676 2 FISYAGEDRAWAE-WLADALEAA-----GYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAA 75
|
90
....*....|....*..
gi 1039729551 791 QSRSLSDLKsiLIVVVV 807
Cdd:pfam13676 76 LADPEGRKR--LIPVRL 90
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
305-596 |
3.95e-09 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 60.63 E-value: 3.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 305 VLQLDLSHGFIFSLNPRLFGTLKDLKMLNLAFNKINKIGENAFYGLDSLQVLNL-SYNLLGELyNSNFYGLPRVAYVDLQ 383
Cdd:PLN00113 286 LISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLwSNKFSGEI-PKNLGKHNNLTVLDLS 364
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 384 RNHI-GIIQD------QTFRLLktLQTLDLRDNALKAIGFIPSIQMVLLGGNKLVHLPHIHFT----ANFLELSENRLE- 451
Cdd:PLN00113 365 TNNLtGEIPEglcssgNLFKLI--LFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTklplVYFLDISNNNLQg 442
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 452 NLSDLYFllRVPQLQFLILNQNRLSSCKAAHTPSENpsLEQLFLTENMLqlaweTGLCWDVFQGLSRLQILYLSNNYLNF 531
Cdd:PLN00113 443 RINSRKW--DMPSLQMLSLARNKFFGGLPDSFGSKR--LENLDLSRNQF-----SGAVPRKLGSLSELMQLKLSENKLSG 513
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039729551 532 LPPGIFNDLVALRMLSLSANKLTvlspGSLPAN------LEILDISRNQLFSPDPALF---SSLRVLDITHNEF 596
Cdd:PLN00113 514 EIPDELSSCKKLVSLDLSHNQLS----GQIPASfsempvLSQLDLSQNQLSGEIPKNLgnvESLVQVNISHNHL 583
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
403-594 |
4.32e-09 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 60.10 E-value: 4.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 403 TLDLRDNALKAI--GFIPSIQMVLLGGNKLVHLPH-IHFTANFLELSENRLENLSDlyfllRVPQ-LQFLILNQNRLSsC 478
Cdd:PRK15370 203 TLILDNNELKSLpeNLQGNIKTLYANSNQLTSIPAtLPDTIQEMELSINRITELPE-----RLPSaLQSLDLFHNKIS-C 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 479 KAAHTPSEnpsLEQLFLTENMLqlaweTGLCWDVFQGLSRLqilYLSNNYLNFLPPGIfndLVALRMLSLSANKLTVLsP 558
Cdd:PRK15370 277 LPENLPEE---LRYLSVYDNSI-----RTLPAHLPSGITHL---NVQSNSLTALPETL---PPGLKTLEAGENALTSL-P 341
|
170 180 190
....*....|....*....|....*....|....*.
gi 1039729551 559 GSLPANLEILDISRNQLFSPDPALFSSLRVLDITHN 594
Cdd:PRK15370 342 ASLPPELQVLDVSKNQITVLPETLPPTITTLDVSRN 377
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
93-556 |
2.41e-08 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 57.25 E-value: 2.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 93 GTQYANLTIGPGAFRNLPNLRILDLGQSQIEVLNRDAFQGLPHLLELRLFSCGLSSAVLSDGYFRNLYSLARLDLSGNQi 172
Cdd:COG4886 29 LLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE- 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 173 hslrlhsSFRELNSLSDVNFAFNQIFTIcEDELEPLQgktlsffglkltklfsrvsvgwetcrnpfrgvRLETLDLSENg 252
Cdd:COG4886 108 -------ELSNLTNLESLDLSGNQLTDL-PEELANLT--------------------------------NLKELDLSNN- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 253 wtvditrnfsniiqgsQISSLilkhhimgpgfgfqnirdpdqstfaslarssvlqldlshgfifslnPRLFGTLKDLKML 332
Cdd:COG4886 147 ----------------QLTDL----------------------------------------------PEPLGNLTNLKSL 164
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 333 NLAFNKINKIGEnAFYGLDSLQVLNLSYNLLGELyNSNFYGLPRVAYVDLQRNHIGIIqDQTFRLLKTLQTLDLRDNALK 412
Cdd:COG4886 165 DLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLT 241
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 413 AIGFI---PSIQMVLLGGNKLVHLPHIHFTAN--FLELSENRLENLSDLYFLLRVPQLQFLILNQNRLSSCKAAHTPSEN 487
Cdd:COG4886 242 DLPELgnlTNLEELDLSNNQLTDLPPLANLTNlkTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLT 321
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039729551 488 PSLEQLFLTENMLQLAWETGLCWDVFQGLSRLQILYLSNNYLNFLPPGIFNDLVALRMLSLSANKLTVL 556
Cdd:COG4886 322 TLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLL 390
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
99-146 |
1.48e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 49.06 E-value: 1.48e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 1039729551 99 LTIGPGAFRNLPNLRILDLGQSQIEVLNRDAFQGLPHLLELRLFSCGL 146
Cdd:pfam13855 14 TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
98-333 |
1.60e-07 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 54.55 E-value: 1.60e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 98 NLTIGPGAFRNLPNLRILDLGQSQIEVLNrDAFQGLPHLLELRLFSCGLSSAvlsdGYFRNLYSLARLDLSGNQIHSLrl 177
Cdd:COG4886 193 QITDLPEPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDL----PELGNLTNLEELDLSNNQLTDL-- 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 178 hSSFRELNSLSDVNFAFNQIFTICedelepLQGKTLSFFGLKLTKLFSRVSVGWETCRNPFRGVRLETLDLSENGWTVDI 257
Cdd:COG4886 266 -PPLANLTNLKTLDLSNNQLTDLK------LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLT 338
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039729551 258 TRNFSNIIQGSQISSLILKHHIMGPGFGFQNIRDPDQSTFASLARSSVLQLDLSHGFIFSLNPRLFGTLKDLKMLN 333
Cdd:COG4886 339 TLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
512-597 |
4.98e-07 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 53.70 E-value: 4.98e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 512 VFQGLSRLQILYLSNNYLNF-LPPGIFNDLVALRMLSLSANKLTVLSPGSLPANLEILDISRNQLFSPDPA---LFSSLR 587
Cdd:PLN00113 88 AIFRLPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNLETLDLSNNMLSGEIPNdigSFSSLK 167
|
90
....*....|
gi 1039729551 588 VLDITHNEFV 597
Cdd:PLN00113 168 VLDLGGNVLV 177
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
353-595 |
5.48e-07 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 52.36 E-value: 5.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 353 LQVLNLSYNLLGELynsnfyGLPRVAYVdlqrnhigiIQDQtfrllKTLQTLDLRDNALKAIG-FIPSIQMVLLGGNKLV 431
Cdd:cd00116 25 LQVLRLEGNTLGEE------AAKALASA---------LRPQ-----PSLKELCLSLNETGRIPrGLQSLLQGLTKGCGLQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 432 HLPhiHFTANFLELSENRLENlsdlyfLLRVPQLQFLILNQNRLSSCKAAHT----PSENPSLEQLFLTENMLqlawETG 507
Cdd:cd00116 85 ELD--LSDNALGPDGCGVLES------LLRSSSLQELKLNNNGLGDRGLRLLakglKDLPPALEKLVLGRNRL----EGA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 508 LCWD---VFQGLSRLQILYLSNNylNFLPPGI------FNDLVALRMLSLSANKLTVLSPGSL------PANLEILDISR 572
Cdd:cd00116 153 SCEAlakALRANRDLKELNLANN--GIGDAGIralaegLKANCNLEVLDLNNNGLTDEGASALaetlasLKSLEVLNLGD 230
|
250 260 270
....*....|....*....|....*....|.
gi 1039729551 573 NQLFSPD--------PALFSSLRVLDITHNE 595
Cdd:cd00116 231 NNLTDAGaaalasalLSPNISLLTLSLSCND 261
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
416-595 |
5.53e-07 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 53.55 E-value: 5.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 416 FIP-SIQMVLLGGNKLVHLPHiHFTANFLELSENrlENLsdlyfLLRVPQ-----LQFLILNQNRLSSCkAAHTPSenpS 489
Cdd:PRK15370 196 CIPeQITTLILDNNELKSLPE-NLQGNIKTLYAN--SNQ-----LTSIPAtlpdtIQEMELSINRITEL-PERLPS---A 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 490 LEQLFLTENMLqlaweTGLCWDVFQGLsrlQILYLSNNYLNFLPPGIFNDLVALRMLSlsaNKLTVLsPGSLPANLEILD 569
Cdd:PRK15370 264 LQSLDLFHNKI-----SCLPENLPEEL---RYLSVYDNSIRTLPAHLPSGITHLNVQS---NSLTAL-PETLPPGLKTLE 331
|
170 180
....*....|....*....|....*.
gi 1039729551 570 ISRNQLFSPDPALFSSLRVLDITHNE 595
Cdd:PRK15370 332 AGENALTSLPASLPPELQVLDVSKNQ 357
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
505-598 |
1.92e-06 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 51.62 E-value: 1.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 505 ETGLCWDVFqGLSRL------QI--LYLSNNYLNFLPPGIFNDLvalRMLSLSANKLTVLsPGSLPANLEILDISRNQLF 576
Cdd:PRK15370 180 KTELRLKIL-GLTTIpacipeQIttLILDNNELKSLPENLQGNI---KTLYANSNQLTSI-PATLPDTIQEMELSINRIT 254
|
90 100
....*....|....*....|..
gi 1039729551 577 SPDPALFSSLRVLDITHNEFVC 598
Cdd:PRK15370 255 ELPERLPSALQSLDLFHNKISC 276
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
352-411 |
4.86e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 44.44 E-value: 4.86e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 352 SLQVLNLSYNLLGELYNSNFYGLPRVAYVDLQRNHIGIIQDQTFRLLKTLQTLDLRDNAL 411
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
443-596 |
1.31e-05 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 47.09 E-value: 1.31e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 443 LELSENRLENLSDLYFLlrvPQLQFLILNQNRLSSCKAAHTpseNPSLEQLFLTENMLQlawetglCWDVFQGLSRLQIL 522
Cdd:cd21340 7 LYLNDKNITKIDNLSLC---KNLKVLYLYDNKITKIENLEF---LTNLTHLYLQNNQIE-------KIENLENLVNLKKL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 523 YLSNNYLNFLpPGiFNDLVALRMLSLSANKLT-----VLSPGSLPA---NLEILDISRNQLFSPDP-ALFSSLRVLDITH 593
Cdd:cd21340 74 YLGGNRISVV-EG-LENLTNLEELHIENQRLPpgeklTFDPRSLAAlsnSLRVLNISGNNIDSLEPlAPLRNLEQLDASN 151
|
...
gi 1039729551 594 NEF 596
Cdd:cd21340 152 NQI 154
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
569-647 |
3.37e-05 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 47.77 E-value: 3.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 569 DISRNQLFSPDPALFS---SLRVLDITHNEFVCNCELSTFISWLNQTNVTLFgSPADVYCMYPNSLLGGSLYNIS--TED 643
Cdd:TIGR00864 1 DISNNKISTIEEGICAnlcNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVR-QPEAALCAGPGALAGQPLLGIPllDSG 79
|
....
gi 1039729551 644 CDEE 647
Cdd:TIGR00864 80 CDEE 83
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
422-596 |
4.25e-05 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 46.85 E-value: 4.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 422 MVLLGGNKLVHLPHIHFTANFLELSENRLENLSDLYFLLRVPQLQFLILNQNRLSSCKAAHTPSENPSLEQLFLTENMLQ 501
Cdd:COG4886 1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 502 LAWETGLCWDVFQGLSRLQIL-----------------YLSNNYLNFLPPGIFNdLVALRMLSLSANKLTVLSP--GSLP 562
Cdd:COG4886 81 LLSLLLLGLTDLGDLTNLTELdlsgneelsnltnleslDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEplGNLT 159
|
170 180 190
....*....|....*....|....*....|....*.
gi 1039729551 563 aNLEILDISRNQLFSPDPALF--SSLRVLDITHNEF 596
Cdd:COG4886 160 -NLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQI 194
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
375-430 |
2.42e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 39.82 E-value: 2.42e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039729551 375 PRVAYVDLQRNHIGIIQDQTFRLLKTLQTLDLRDNALK-----AIGFIPSIQMVLLGGNKL 430
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTtlspgAFSGLPSLRYLDLSGNRL 61
|
|
| PRK15387 |
PRK15387 |
type III secretion system effector E3 ubiquitin transferase SspH2; |
401-620 |
3.27e-04 |
|
type III secretion system effector E3 ubiquitin transferase SspH2;
Pssm-ID: 185285 [Multi-domain] Cd Length: 788 Bit Score: 44.38 E-value: 3.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 401 LQTLDLRDNALKAIGFIPS-IQMVLLGGNKLVHLPHIHFTANFLELSENRLENLSDLyfllrVPQLQFLILNQNRLSSck 479
Cdd:PRK15387 264 LLELSIFSNPLTHLPALPSgLCKLWIFGNQLTSLPVLPPGLQELSVSDNQLASLPAL-----PSELCKLWAYNNQLTS-- 336
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 480 aahTPSENPSLEQLFLTENmlQLAWETGLCWDVFQglsrlqiLYLSNNYLNFLP--PGifndlvALRMLSLSANKLTVLS 557
Cdd:PRK15387 337 ---LPTLPSGLQELSVSDN--QLASLPTLPSELYK-------LWAYNNRLTSLPalPS------GLKELIVSGNRLTSLP 398
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039729551 558 pgSLPANLEILDISRNQLFSPdPALFSSLRVLDITHNEFVCNCElsTFISWLNQTNVTLFGSP 620
Cdd:PRK15387 399 --VLPSELKELMVSGNRLTSL-PMLPSGLLSLSVYRNQLTRLPE--SLIHLSSETTVNLEGNP 456
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
463-529 |
3.35e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 39.43 E-value: 3.35e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039729551 463 PQLQFLILNQNRLSSCKAaHTPSENPSLEQLFLTENMLqlaweTGLCWDVFQGLSRLQILYLSNNYL 529
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDD-GAFKGLSNLKVLDLSNNLL-----TTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
110-197 |
9.88e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 38.27 E-value: 9.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 110 PNLRILDLGQSQIEVLNRDAFQGLPHLLELrlfscglssavlsdgyfrnlyslarlDLSGNQIHSLRLHsSFRELNSLSD 189
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVL--------------------------DLSNNLLTTLSPG-AFSGLPSLRY 53
|
....*...
gi 1039729551 190 VNFAFNQI 197
Cdd:pfam13855 54 LDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
106-195 |
1.30e-03 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 41.31 E-value: 1.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 106 FRNLPNLRILDLGQSQIEVLNrdAFQGLPHLLELRL------------FSCGLSSAVL--------------SDGYFRNL 159
Cdd:cd21340 64 LENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIenqrlppgekltFDPRSLAALSnslrvlnisgnnidSLEPLAPL 141
|
90 100 110
....*....|....*....|....*....|....*..
gi 1039729551 160 YSLARLDLSGNQIHSLR-LHSSFRELNSLSDVNFAFN 195
Cdd:cd21340 142 RNLEQLDASNNQISDLEeLLDLLSSWPSLRELDLTGN 178
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
457-575 |
3.49e-03 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 40.42 E-value: 3.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039729551 457 YFLLRVPQLQFLILNQNRLS------SCKAAHTPsenPSLEQLFLTENMLQLAWE-TGLCWDVFQGLSRLQILYLSNNYL 529
Cdd:cd00116 17 ELLPKLLCLQVLRLEGNTLGeeaakaLASALRPQ---PSLKELCLSLNETGRIPRgLQSLLQGLTKGCGLQELDLSDNAL 93
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1039729551 530 NFLPPGIFNDL---VALRMLSLSANKLTVL-------SPGSLPANLEILDISRNQL 575
Cdd:cd00116 94 GPDGCGVLESLlrsSSLQELKLNNNGLGDRglrllakGLKDLPPALEKLVLGRNRL 149
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
594-645 |
9.08e-03 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 35.10 E-value: 9.08e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 1039729551 594 NEFVCNCELSTFISWLNQTNVtlFGSPADVYCMYPNSLLGGSL-YNISTEDCD 645
Cdd:smart00082 1 NPFICDCELRWLLRWLQANEH--LQDPVDLRCASPSSLRGPLLeLLHSEFKCP 51
|
|
| |
