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Conserved domains on  [gi|1207179854|ref|XP_017212642|]
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low-density lipoprotein receptor-related protein 4 isoform X1 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1184-1224 1.71e-13

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 66.03  E-value: 1.71e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1207179854 1184 GYMYWTDWGEHAKLERSSMDGSDRVVLINNNLGWPNGLAVD 1224
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 507-547 3.04e-13

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 65.32  E-value: 3.04e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1207179854   507 VVSTGLESPGGLAIDWIHNKLYWTDSGTSRIEVSNLDGTHR 547
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 272-306 5.45e-13

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 64.54  E-value: 5.45e-13
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1207179854  272 CMADQFRCMSGRCVRLSWRCDGEDDCSDGSDEEGC 306
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
72-107 6.82e-13

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 64.19  E-value: 6.82e-13
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1207179854   72 TCSPLDFHCENGKCIRRSWLCDGDNDCEDDSDEQDC 107
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 813-855 3.67e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 62.23  E-value: 3.67e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1207179854   813 EVVVDTSLESPAGLAIDWLTHKLYWTDAGTDRIEVSNTDGSMR 855
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1425-1467 7.79e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.46  E-value: 7.79e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1207179854  1425 ETVISSGLKTTDGLAVDWVARNMYWTDTGRNTIEVAHLDGTSR 1467
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 592-634 2.97e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 2.97e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1207179854   592 KIIADTHLFWPNGLTIDYASHRMYWVDAKHHVIERADLDGKNR 634
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 150-184 3.70e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.14  E-value: 3.70e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1207179854  150 CSDKEFRCTDGSCIAEHWYCDGDSDCKDGTDEENC 184
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 568-609 5.59e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 59.10  E-value: 5.59e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1207179854  568 GKIYWTDWGNMPRIEYANMDGSNRKIIADTHLFWPNGLTIDY 609
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1512-1552 6.43e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.77  E-value: 6.43e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1207179854  1512 KVLINTDLGWPNGLTLDYDTRRIFWVDAHLDRIESSDLNGK 1552
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 111-143 1.10e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


:

Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.03  E-value: 1.10e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1207179854   111 ECEEDEFHCQNGYCIRSLWYCDGDNDCGDNSDE 143
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 233-267 1.22e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 1.22e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1207179854  233 CRSAEFMCSSGMCINAGWRCDGEFDCDDQSDEKNC 267
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1488-1529 1.97e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.55  E-value: 1.97e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1207179854 1488 GFLFWTDWGHIAKIERAFLDGTDRKVLINTDLGWPNGLTLDY 1529
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1123-1163 2.23e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.23  E-value: 2.23e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1207179854  1123 IISTGLMTTDGLAVDSVGRKIYWTDTGTNRIEVANLNGSMR 1163
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1090-1282 2.39e-10

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd05819:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 269  Bit Score: 63.49  E-value: 2.39e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1090 AIGVDPiEGKVYWSDSTLKKISRSNINGTEHEDIISTGLMTTD-----GLAVDSVGRkIYWTDTGTNRIEVANLNGSMRK 1164
Cdd:cd05819     59 GVAVDS-DGNLYVADTGNHRIQKFDPDGNFLASFGGSGDGDGEfngprGIAVDSSGN-IYVADTGNHRIQKFDPDGEFLT 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1165 VL-----VWQNLDSPRAIALYHEmGYMYWTDWGEHaklerssmdgsdRVVLINNN----------------LGWPNGLAV 1223
Cdd:cd05819    137 TFgsggsGPGQFNGPTGVAVDSD-GNIYVADTGNH------------RIQVFDPDgnflttfgstgtgpgqFNYPTGIAV 203

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207179854 1224 DKAGSqLLWADAHTERIEASDLNGS------NRRTLVSPVQHPYGLTVLGS-HMYWTDWQSRSIHR 1282
Cdd:cd05819    204 DSDGN-IYVADSGNNRVQVFDPDGAgfggngNFLGSDGQFNRPSGLAVDSDgNLYVADTGNNRIQV 268
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 901-942 3.26e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.84  E-value: 3.26e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1207179854   901 VIISSNLTWPNGLAIDYSTERLYWADASVKTIEYGNFDGSGR 942
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1011-1048 4.03e-10

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 56.48  E-value: 4.03e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1207179854 1011 CLVNNGGCSHLCLlaPAPKSWSCACPTGINLQADGKTC 1048
Cdd:pfam14670    1 CSVNNGGCSHLCL--NTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 876-917 7.92e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 55.63  E-value: 7.92e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1207179854  876 GFMYWTDWGANPKIERAGMDAWNRTVIISSNLTWPNGLAIDY 917
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 29-68 1.07e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.29  E-value: 1.07e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1207179854   29 CGKNHFTCAVSafgecTCIPAQWQCDGDNDCGDHSDEDGC 68
Cdd:cd00112      1 CPPNEFRCANG-----RCIPSSWVCDGEDDCGDGSDEENC 35
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1318-1353 1.97e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 54.56  E-value: 1.97e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1207179854 1318 CGRRNGGCSHLCLPRLNGTSCACPTGVLLKADGRSC 1353
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 314-345 4.37e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 4.37e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1207179854  314 CAPDQFLCGNGRCIGQRKVCNDVKDCEDGTDE 345
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 360-395 8.53e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 52.63  E-value: 8.53e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1207179854  360 CNVNNGGCSQKCQMSRGLVQCTCHTGYTLTADGKTC 395
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Vgb super family cl26743
Streptogramin lyase [Defense mechanisms];
1336-1608 1.81e-08

Streptogramin lyase [Defense mechanisms];


The actual alignment was detected with superfamily member COG4257:

Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 57.72  E-value: 1.81e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1336 TSCACPTGVLLKADGRscedlpetyLLFSNRVSVRRISLDTHDHTDVFVPVAELQNVISLDYDSvERKLYYTDVSLDVIR 1415
Cdd:COG4257     14 APGSGPRDVAVDPDGA---------VWFTDQGGGRIGRLDPATGEFTEYPLGGGSGPHGIAVDP-DGNLWFTDNGNNRIG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1416 RVNLDGSDMETVISSGLKTTD-GLAVDwvARNMYW-TDTGRNTIevAHLDGTSRKVLVNNSLDE---PRAIAVFPsKGFL 1490
Cdd:COG4257     84 RIDPKTGEITTFALPGGGSNPhGIAFD--PDGNLWfTDQGGNRI--GRLDPATGEVTEFPLPTGgagPYGIAVDP-DGNL 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1491 FWTDWG--HIAKIERAflDGTDRKVLINTDLGWPNGLTLDYDTRrIFWVDA---HLDRIESSDlnGKLRQILIS-PVSHP 1564
Cdd:COG4257    159 WVTDFGanAIGRIDPD--TGTLTEYALPTPGAGPRGLAVDPDGN-LWVADTgsgRIGRFDPKT--GTVTEYPLPgGGARP 233

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 1207179854 1565 FALTqlkpvyspltpfsriSQQERWIYWTDWQTKSIQRVDKHTG 1608
Cdd:COG4257    234 YGVA---------------VDGDGRVWFAESGANRIVRFDPDTE 262
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 705-739 5.07e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 50.32  E-value: 5.07e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1207179854  705 CGSNNGGCSHLCLPSNKTYTCVCPTGFR-KLDQHNC 739
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYElQDDGRTC 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
766-987 9.10e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


:

Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 55.09  E-value: 9.10e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  766 LDAVIPLADVRNAVALDWDSLDSESFIYWTDVTTDSINRALWDGSKQEVVVDTSLESPAGLAIDWLT-----HKLYWTDA 840
Cdd:COG3391      8 LVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADagadgRRLYVANS 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  841 GTDRIEVSNTDgSMRTVLIWENLDRPRDIVVDPIGGFMYWTDWGANpKIerAGMDAWNRTVIISSNL-TWPNGLAIDYST 919
Cdd:COG3391     88 GSGRVSVIDLA-TGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNG-RV--SVIDTATGKVVATIPVgAGPHGIAVDPDG 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  920 ERLYWADASVKTI-----EygnFDGSGRQVL----IGSqlpHPFGLTLHED--RIYWTDWQS-KSIQSADKLTGLDRKTL 987
Cdd:COG3391    164 KRLYVANSGSNTVsvivsV---IDTATGKVVatipVGG---GPVGVAVSPDgrRLYVANRGSnTSNGGSNTVSVIDLATL 237
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 473-690 2.44e-07

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd05819:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 269  Bit Score: 54.25  E-value: 2.44e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  473 IALDFHHSqelVFWSDVTLDRIMRASLNGSNVEEVVSTG-----LESPGGLAIDwIHNKLYWTDSGTSRIEVSNLDGTHR 547
Cdd:cd05819     13 IAVDSSGN---IYVADTGNNRIQVFDPDGNFITSFGSFGsgdgqFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFL 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  548 KVLL-----WQRMEKPRAIALHPiEGKIYWTDWGNMpRIEYANMDGSNRKII-----ADTHLFWPNGLTIDyASHRMYWV 617
Cdd:cd05819     89 ASFGgsgdgDGEFNGPRGIAVDS-SGNIYVADTGNH-RIQKFDPDGEFLTTFgsggsGPGQFNGPTGVAVD-SDGNIYVA 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  618 DAKHHVIERADLDGKNRKAVISQGLP-----HPFAITVFED-SLYWTDWHTKSInsaNKFTGKNQEVIRN--------KL 683
Cdd:cd05819    166 DTGNHRIQVFDPDGNFLTTFGSTGTGpgqfnYPTGIAVDSDgNIYVADSGNNRV---QVFDPDGAGFGGNgnflgsdgQF 242


                   ....*..
gi 1207179854  684 HFPMDIH 690
Cdd:cd05819    243 NRPSGLA 249
EGF_CA smart00179
Calcium-binding EGF-like domain;
397-436 3.27e-06

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 3.27e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1207179854   397 DVDECADDGYCSQG--CTNIEGGFQCWCVQGYElrpDKRSCK 436
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGYT---DGRNCE 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1638-1662 6.94e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.54  E-value: 6.94e-06
                           10        20
                   ....*....|....*....|....*
gi 1207179854 1638 CAANNGGCTHLCLARSNSFICACPD 1662
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPE 25
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1184-1224 1.71e-13

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 66.03  E-value: 1.71e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1207179854 1184 GYMYWTDWGEHAKLERSSMDGSDRVVLINNNLGWPNGLAVD 1224
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 507-547 3.04e-13

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 65.32  E-value: 3.04e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1207179854   507 VVSTGLESPGGLAIDWIHNKLYWTDSGTSRIEVSNLDGTHR 547
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 272-306 5.45e-13

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 64.54  E-value: 5.45e-13
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1207179854  272 CMADQFRCMSGRCVRLSWRCDGEDDCSDGSDEEGC 306
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
72-107 6.82e-13

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 64.19  E-value: 6.82e-13
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1207179854   72 TCSPLDFHCENGKCIRRSWLCDGDNDCEDDSDEQDC 107
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 813-855 3.67e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 62.23  E-value: 3.67e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1207179854   813 EVVVDTSLESPAGLAIDWLTHKLYWTDAGTDRIEVSNTDGSMR 855
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1425-1467 7.79e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.46  E-value: 7.79e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1207179854  1425 ETVISSGLKTTDGLAVDWVARNMYWTDTGRNTIEVAHLDGTSR 1467
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 272-303 1.16e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 60.72  E-value: 1.16e-11
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1207179854   272 CMADQFRCMSGRCVRLSWRCDGEDDCSDGSDE 303
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 73-107 1.24e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.68  E-value: 1.24e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1207179854   73 CSPLDFHCENGKCIRRSWLCDGDNDCEDDSDEQDC 107
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
272-306 1.33e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 60.73  E-value: 1.33e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1207179854  272 CMADQFRCMSGRCVRLSWRCDGEDDCSDGSDEEGC 306
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 592-634 2.97e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 2.97e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1207179854   592 KIIADTHLFWPNGLTIDYASHRMYWVDAKHHVIERADLDGKNR 634
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 150-184 3.70e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.14  E-value: 3.70e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1207179854  150 CSDKEFRCTDGSCIAEHWYCDGDSDCKDGTDEENC 184
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 568-609 5.59e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 59.10  E-value: 5.59e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1207179854  568 GKIYWTDWGNMPRIEYANMDGSNRKIIADTHLFWPNGLTIDY 609
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1512-1552 6.43e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.77  E-value: 6.43e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1207179854  1512 KVLINTDLGWPNGLTLDYDTRRIFWVDAHLDRIESSDLNGK 1552
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
148-184 9.19e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.41  E-value: 9.19e-11
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1207179854  148 RKCSDKEFRCTDGSCIAEHWYCDGDSDCKDGTDEENC 184
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 111-143 1.10e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.03  E-value: 1.10e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1207179854   111 ECEEDEFHCQNGYCIRSLWYCDGDNDCGDNSDE 143
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 233-267 1.22e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 1.22e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1207179854  233 CRSAEFMCSSGMCINAGWRCDGEFDCDDQSDEKNC 267
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 112-144 1.23e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 1.23e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1207179854  112 CEEDEFHCQNGYCIRSLWYCDGDNDCGDNSDEQ 144
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1488-1529 1.97e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.55  E-value: 1.97e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1207179854 1488 GFLFWTDWGHIAKIERAFLDGTDRKVLINTDLGWPNGLTLDY 1529
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1123-1163 2.23e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.23  E-value: 2.23e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1207179854  1123 IISTGLMTTDGLAVDSVGRKIYWTDTGTNRIEVANLNGSMR 1163
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1090-1282 2.39e-10

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 63.49  E-value: 2.39e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1090 AIGVDPiEGKVYWSDSTLKKISRSNINGTEHEDIISTGLMTTD-----GLAVDSVGRkIYWTDTGTNRIEVANLNGSMRK 1164
Cdd:cd05819     59 GVAVDS-DGNLYVADTGNHRIQKFDPDGNFLASFGGSGDGDGEfngprGIAVDSSGN-IYVADTGNHRIQKFDPDGEFLT 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1165 VL-----VWQNLDSPRAIALYHEmGYMYWTDWGEHaklerssmdgsdRVVLINNN----------------LGWPNGLAV 1223
Cdd:cd05819    137 TFgsggsGPGQFNGPTGVAVDSD-GNIYVADTGNH------------RIQVFDPDgnflttfgstgtgpgqFNYPTGIAV 203

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207179854 1224 DKAGSqLLWADAHTERIEASDLNGS------NRRTLVSPVQHPYGLTVLGS-HMYWTDWQSRSIHR 1282
Cdd:cd05819    204 DSDGN-IYVADSGNNRVQVFDPDGAgfggngNFLGSDGQFNRPSGLAVDSDgNLYVADTGNNRIQV 268
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 72-104 2.86e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.87  E-value: 2.86e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1207179854    72 TCSPLDFHCENGKCIRRSWLCDGDNDCEDDSDE 104
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 901-942 3.26e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.84  E-value: 3.26e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1207179854   901 VIISSNLTWPNGLAIDYSTERLYWADASVKTIEYGNFDGSGR 942
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1011-1048 4.03e-10

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 56.48  E-value: 4.03e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1207179854 1011 CLVNNGGCSHLCLlaPAPKSWSCACPTGINLQADGKTC 1048
Cdd:pfam14670    1 CSVNNGGCSHLCL--NTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
232-267 4.22e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.49  E-value: 4.22e-10
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1207179854  232 PCRSAEFMCSSGMCINAGWRCDGEFDCDDQSDEKNC 267
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 876-917 7.92e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 55.63  E-value: 7.92e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1207179854  876 GFMYWTDWGANPKIERAGMDAWNRTVIISSNLTWPNGLAIDY 917
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
112-144 8.21e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 55.72  E-value: 8.21e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1207179854  112 CEEDEFHCQNGYCIRSLWYCDGDNDCGDNSDEQ 144
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 29-68 1.07e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.29  E-value: 1.07e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1207179854   29 CGKNHFTCAVSafgecTCIPAQWQCDGDNDCGDHSDEDGC 68
Cdd:cd00112      1 CPPNEFRCANG-----RCIPSSWVCDGEDDCGDGSDEENC 35
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1384-1543 1.44e-09

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 60.48  E-value: 1.44e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1384 VPVAELQNVISLDYDSVERKLYYTDVSLDVIRRVNLDGSDMETVISSGlKTTDGLAVDWVARNMYWTDTGRNTIEVahLD 1463
Cdd:COG3391     62 LGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSV--ID 138

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1464 GTSRKVLVNNSL-DEPRAIAVFPSKGFLFWTDWGH--IAKIERAFlDGTDRKVLINTDLG-WPNGLTLDYDTRRIFWVDA 1539
Cdd:COG3391    139 TATGKVVATIPVgAGPHGIAVDPDGKRLYVANSGSntVSVIVSVI-DTATGKVVATIPVGgGPVGVAVSPDGRRLYVANR 217


                   ....
gi 1207179854 1540 HLDR 1543
Cdd:COG3391    218 GSNT 221
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1318-1353 1.97e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 54.56  E-value: 1.97e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1207179854 1318 CGRRNGGCSHLCLPRLNGTSCACPTGVLLKADGRSC 1353
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 548-591 2.07e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.53  E-value: 2.07e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1207179854   548 KVLLWQRMEKPRAIALHPIEGKIYWTDWGNmPRIEYANMDGSNR 591
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 149-181 2.30e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.18  E-value: 2.30e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1207179854   149 KCSDKEFRCTDGSCIAEHWYCDGDSDCKDGTDE 181
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 233-264 3.67e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.79  E-value: 3.67e-09
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1207179854   233 CRSAEFMCSSGMCINAGWRCDGEFDCDDQSDE 264
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 314-345 4.37e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 4.37e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1207179854  314 CAPDQFLCGNGRCIGQRKVCNDVKDCEDGTDE 345
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 473-660 5.14e-09

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 59.23  E-value: 5.14e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  473 IALDfhhSQELVFWSDVTLDRIMRASLNG----SNVEEVVSTGLESPGGLAIDwiHNKLYWTDSGTSRIEVSNLDGthRK 548
Cdd:cd14963     61 IAVD---SDGNIYVADLYNGRIQVFDPDGkflkYFPEKKDRVKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEG--KL 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  549 VLLWQRMEK-------PRAIALHPiEGKIYWTDWGNMpRIEYANMDGSNRKIIA-----DTHLFWPNGltIDYASH-RMY 615
Cdd:cd14963    134 LLEFGKPGSepgelsyPNGIAVDE-DGNIYVADSGNG-RIQVFDKNGKFIKELNgspdgKSGFVNPRG--IAVDPDgNLY 209

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1207179854  616 WVDAKHHVIERADLDGKNRKAVISQG-----LPHPFAITVFEDS-LYWTDW 660
Cdd:cd14963    210 VVDNLSHRVYVFDEQGKELFTFGGRGkddgqFNLPNGLFIDDDGrLYVTDR 260
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1468-1511 6.57e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.99  E-value: 6.57e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1207179854  1468 KVLVNNSLDEPRAIAVFPSKGFLFWTDWGHiAKIERAFLDGTDR 1511
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 360-395 8.53e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 52.63  E-value: 8.53e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1207179854  360 CNVNNGGCSQKCQMSRGLVQCTCHTGYTLTADGKTC 395
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1124-1293 1.29e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 57.78  E-value: 1.29e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1124 ISTGLMTTDGLAVDSVGRKIYWTDTGTNRIEVANLNgSMRKVLVWQNLDSPRAIALYHEMGYMYWTDWGEHAKlerSSMD 1203
Cdd:COG3391     63 GAAAVADADGADAGADGRRLYVANSGSGRVSVIDLA-TGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRV---SVID 138

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1204 GSDRVVLINNNLG-WPNGLAVDKAGSQLLWADAHTERIEA--SDLNGSNRRTL--VSPVQHPYGLTVL--GSHMYWTDWQ 1276
Cdd:COG3391    139 TATGKVVATIPVGaGPHGIAVDPDGKRLYVANSGSNTVSVivSVIDTATGKVVatIPVGGGPVGVAVSpdGRRLYVANRG 218

                          170
                   ....*....|....*..
gi 1207179854 1277 SrsiHRADKNTGENAII 1293
Cdd:COG3391    219 S---NTSNGGSNTVSVI 232
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1209-1250 1.56e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.22  E-value: 1.56e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1207179854  1209 VLINNNLGWPNGLAVDKAGSQLLWADAHTERIEASDLNGSNR 1250
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 314-345 1.69e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.87  E-value: 1.69e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1207179854   314 CAPDQFLCGNGRCIGQRKVCNDVKDCEDGTDE 345
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1336-1608 1.81e-08

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 57.72  E-value: 1.81e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1336 TSCACPTGVLLKADGRscedlpetyLLFSNRVSVRRISLDTHDHTDVFVPVAELQNVISLDYDSvERKLYYTDVSLDVIR 1415
Cdd:COG4257     14 APGSGPRDVAVDPDGA---------VWFTDQGGGRIGRLDPATGEFTEYPLGGGSGPHGIAVDP-DGNLWFTDNGNNRIG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1416 RVNLDGSDMETVISSGLKTTD-GLAVDwvARNMYW-TDTGRNTIevAHLDGTSRKVLVNNSLDE---PRAIAVFPsKGFL 1490
Cdd:COG4257     84 RIDPKTGEITTFALPGGGSNPhGIAFD--PDGNLWfTDQGGNRI--GRLDPATGEVTEFPLPTGgagPYGIAVDP-DGNL 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1491 FWTDWG--HIAKIERAflDGTDRKVLINTDLGWPNGLTLDYDTRrIFWVDA---HLDRIESSDlnGKLRQILIS-PVSHP 1564
Cdd:COG4257    159 WVTDFGanAIGRIDPD--TGTLTEYALPTPGAGPRGLAVDPDGN-LWVADTgsgRIGRFDPKT--GTVTEYPLPgGGARP 233

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 1207179854 1565 FALTqlkpvyspltpfsriSQQERWIYWTDWQTKSIQRVDKHTG 1608
Cdd:COG4257    234 YGVA---------------VDGDGRVWFAESGANRIVRFDPDTE 262
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1141-1181 3.20e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.01  E-value: 3.20e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1207179854 1141 RKIYWTDTGT-NRIEVANLNGSMRKVLVWQNLDSPRAIALYH 1181
Cdd:pfam00058    1 GRLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 705-739 5.07e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 50.32  E-value: 5.07e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1207179854  705 CGSNNGGCSHLCLPSNKTYTCVCPTGFR-KLDQHNC 739
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYElQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 857-899 5.95e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.29  E-value: 5.95e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1207179854   857 VLIWENLDRPRDIVVDPIGGFMYWTDWGaNPKIERAGMDAWNR 899
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 29-65 7.33e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.94  E-value: 7.33e-08
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1207179854    29 CGKNHFTCAVSafgecTCIPAQWQCDGDNDCGDHSDE 65
Cdd:smart00192    2 CPPGEFQCDNG-----RCIPSSWVCDGVDDCGDGSDE 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
766-987 9.10e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 55.09  E-value: 9.10e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  766 LDAVIPLADVRNAVALDWDSLDSESFIYWTDVTTDSINRALWDGSKQEVVVDTSLESPAGLAIDWLT-----HKLYWTDA 840
Cdd:COG3391      8 LVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADagadgRRLYVANS 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  841 GTDRIEVSNTDgSMRTVLIWENLDRPRDIVVDPIGGFMYWTDWGANpKIerAGMDAWNRTVIISSNL-TWPNGLAIDYST 919
Cdd:COG3391     88 GSGRVSVIDLA-TGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNG-RV--SVIDTATGKVVATIPVgAGPHGIAVDPDG 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  920 ERLYWADASVKTI-----EygnFDGSGRQVL----IGSqlpHPFGLTLHED--RIYWTDWQS-KSIQSADKLTGLDRKTL 987
Cdd:COG3391    164 KRLYVANSGSNTVsvivsV---IDTATGKVVatipVGG---GPVGVAVSPDgrRLYVANRGSnTSNGGSNTVSVIDLATL 237
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
29-68 2.07e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.78  E-value: 2.07e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1207179854   29 CGKNHFTCAVSafgecTCIPAQWQCDGDNDCGDHSDEDGC 68
Cdd:pfam00057    3 CSPNEFQCGSG-----ECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1445-1485 2.34e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.70  E-value: 2.34e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1207179854 1445 RNMYWTDTG-RNTIEVAHLDGTSRKVLVNNSLDEPRAIAVFP 1485
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 473-690 2.44e-07

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 54.25  E-value: 2.44e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  473 IALDFHHSqelVFWSDVTLDRIMRASLNGSNVEEVVSTG-----LESPGGLAIDwIHNKLYWTDSGTSRIEVSNLDGTHR 547
Cdd:cd05819     13 IAVDSSGN---IYVADTGNNRIQVFDPDGNFITSFGSFGsgdgqFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFL 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  548 KVLL-----WQRMEKPRAIALHPiEGKIYWTDWGNMpRIEYANMDGSNRKII-----ADTHLFWPNGLTIDyASHRMYWV 617
Cdd:cd05819     89 ASFGgsgdgDGEFNGPRGIAVDS-SGNIYVADTGNH-RIQKFDPDGEFLTTFgsggsGPGQFNGPTGVAVD-SDGNIYVA 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  618 DAKHHVIERADLDGKNRKAVISQGLP-----HPFAITVFED-SLYWTDWHTKSInsaNKFTGKNQEVIRN--------KL 683
Cdd:cd05819    166 DTGNHRIQVFDPDGNFLTTFGSTGTGpgqfnYPTGIAVDSDgNIYVADSGNNRV---QVFDPDGAGFGGNgnflgsdgQF 242


                   ....*..
gi 1207179854  684 HFPMDIH 690
Cdd:cd05819    243 NRPSGLA 249
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 613-652 2.63e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.70  E-value: 2.63e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1207179854  613 RMYWVDAK-HHVIERADLDGKNRKAVISQGLPHPFAITVFE 652
Cdd:pfam00058    2 RLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 834-873 3.33e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.31  E-value: 3.33e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1207179854  834 KLYWTDAGTD-RIEVSNTDGSMRTVLIWENLDRPRDIVVDP 873
Cdd:pfam00058    2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 785-974 5.95e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 53.06  E-value: 5.95e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  785 SLDSESFIYWTDVTTDSINRALWDGSKQEVVVDTS----LESPAGLAIDwlTHKLYWTDAGTDRIEVSNTDGSMrtVLIW 860
Cdd:cd14963     62 AVDSDGNIYVADLYNGRIQVFDPDGKFLKYFPEKKdrvkLISPAGLAID--DGKLYVSDVKKHKVIVFDLEGKL--LLEF 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  861 -------ENLDRPRDIVVDPiGGFMYWTDWGaNPKI-----ERAGMDAWNRTVIISSNLTWPNGLAIDySTERLYWADAS 928
Cdd:cd14963    138 gkpgsepGELSYPNGIAVDE-DGNIYVADSG-NGRIqvfdkNGKFIKELNGSPDGKSGFVNPRGIAVD-PDGNLYVVDNL 214

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1207179854  929 VKTIEYGNFDG-----SGRQVLIGSQLPHPFGLTLHED-RIYWTDWQSKSIQ 974
Cdd:cd14963    215 SHRVYVFDEQGkelftFGGRGKDDGQFNLPNGLFIDDDgRLYVTDRENNRVA 266
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 525-565 1.09e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.77  E-value: 1.09e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1207179854  525 NKLYWTDSGTS-RIEVSNLDGTHRKVLLWQRMEKPRAIALHP 565
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
313-345 2.07e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.09  E-value: 2.07e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1207179854  313 PCAPDQFLCGNGRCIGQRKVCNDVKDCEDGTDE 345
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
397-436 3.27e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 3.27e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1207179854   397 DVDECADDGYCSQG--CTNIEGGFQCWCVQGYElrpDKRSCK 436
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGYT---DGRNCE 39
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1164-1207 3.58e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 45.29  E-value: 3.58e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1207179854  1164 KVLVWQNLDSPRAIALYHEMGYMYWTDWGeHAKLERSSMDGSDR 1207
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 462-504 3.76e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 45.29  E-value: 3.76e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1207179854   462 YTLLLSNLENAIALDFHHSQELVFWSDVTLDRIMRASLNGSNV 504
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1638-1662 6.94e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.54  E-value: 6.94e-06
                           10        20
                   ....*....|....*....|....*
gi 1207179854 1638 CAANNGGCTHLCLARSNSFICACPD 1662
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPE 25
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1404-1551 7.08e-06

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 49.62  E-value: 7.08e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1404 LYYTDVSLDVIRRVNLDGSDMETVISSGLKTTD-----GLAVD-----WVArnmywtDTGRNTIEVAHLDGTSRKVL--- 1470
Cdd:cd05819     68 LYVADTGNHRIQKFDPDGNFLASFGGSGDGDGEfngprGIAVDssgniYVA------DTGNHRIQKFDPDGEFLTTFgsg 141

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1471 --VNNSLDEPRAIAVFPSkGFLFWTDWGH--IAKI--ERAFLDGTDRKVLINTDLGWPNGLTLDYDTrRIFWVDAHLDRI 1544
Cdd:cd05819    142 gsGPGQFNGPTGVAVDSD-GNIYVADTGNhrIQVFdpDGNFLTTFGSTGTGPGQFNYPTGIAVDSDG-NIYVADSGNNRV 219


                   ....*..
gi 1207179854 1545 ESSDLNG 1551
Cdd:cd05819    220 QVFDPDG 226
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1389-1423 1.16e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 44.13  E-value: 1.16e-05
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1207179854  1389 LQNVISLDYDSVERKLYYTDVSLDVIRRVNLDGSD 1423
Cdd:smart00135    8 LGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 397-429 1.49e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.49e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1207179854  397 DVDECADDGYCSQG--CTNIEGGFQCWCVQGYELR 429
Cdd:cd00054      1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGYTGR 35
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
484-638 1.50e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.54  E-value: 1.50e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  484 VFWSDVTLDRIMRASLNGSNVEEVVSTGlESPGGLAIDWIHNKLYWTDSGTSRIEVsnLDGTHRKVLlwQRM---EKPRA 560
Cdd:COG3391     82 LYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVV--ATIpvgAGPHG 156

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  561 IALHPIEGKIYWTDWGN--MPRIEYAnMDGSNRKIIADTHL-FWPNGLTIDYASHRMYWVDAKHHvieRADLDGkNRKAV 637
Cdd:COG3391    157 IAVDPDGKRLYVANSGSntVSVIVSV-IDTATGKVVATIPVgGGPVGVAVSPDGRRLYVANRGSN---TSNGGS-NTVSV 231


                   .
gi 1207179854  638 I 638
Cdd:COG3391    232 I 232
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 943-984 2.43e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 42.97  E-value: 2.43e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1207179854   943 QVLIGSQLPHPFGLTLH--EDRIYWTDWQSKSIQSADkLTGLDR 984
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDwiEGRLYWTDWGLDVIEVAN-LDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 403-435 2.44e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 43.00  E-value: 2.44e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1207179854  403 DDGYCSQGCTNIEGGFQCWCVQGYELRPDKRSC 435
Cdd:pfam14670    4 NNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 1094-1273 1.36e-04

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 45.72  E-value: 1.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1094 DPIEGKVYWSDSTLKKISRSNINGTEHEDI-----ISTGLMTTDGLAVDSVGRKIYWTDTGTNRIEV-----------AN 1157
Cdd:pfam08450    8 DEEEGALYWVDILGGRIHRLDPATGKETVWdtpgpVGAIAPRDDGGLIVALKDGVALLDLATGELTPladpedddwplNR 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1158 LN------------GSMRKvlvwqNLDSPRAI-ALYHemgymywtdwgehaklerssMDGSDRVVLINNNLGWPNGLAVD 1224
Cdd:pfam08450   88 FNdgkvdpdgrfwfGTMGD-----DEAPGGDPgALYR--------------------LDPDGKLTRVLDGLTISNGLAWS 142

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1207179854 1225 KAGSQLLWADAHTERIEASDLNG-----SNRRTLVSPVQH---PYGLTVLGSHMYWT 1273
Cdd:pfam08450  143 PDGRTLYFADSPARKIWAYDYDLdggliSNRRVFADFKPGlgrPDGMAVDAEGNVWV 199
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1402-1442 2.34e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 40.22  E-value: 2.34e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1207179854 1402 RKLYYTDVSLD-VIRRVNLDGSDMETVISSGLKTTDGLAVDW 1442
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 791-830 7.05e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.07  E-value: 7.05e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1207179854  791 FIYWTDVTTD-SINRALWDGSKQEVVVDTSLESPAGLAIDW 830
Cdd:pfam00058    2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
 498-544 8.03e-04

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 44.46  E-value: 8.03e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1207179854  498 SLNGSNVEEVVSTGLESPGGLAIDWIHNKLYWTDSGTSRIEVSNLDG 544
Cdd:PLN02919   553 SLEKDNDPRLLTSPLKFPGKLAIDLLNNRLFISDSNHNRIVVTDLDG 599
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 482-522 9.66e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 38.68  E-value: 9.66e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1207179854  482 ELVFWSDVTLD-RIMRASLNGSNVEEVVSTGLESPGGLAIDW 522
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
 
Name Accession Description Interval E-value
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1184-1224 1.71e-13

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 66.03  E-value: 1.71e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1207179854 1184 GYMYWTDWGEHAKLERSSMDGSDRVVLINNNLGWPNGLAVD 1224
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 507-547 3.04e-13

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 65.32  E-value: 3.04e-13
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1207179854   507 VVSTGLESPGGLAIDWIHNKLYWTDSGTSRIEVSNLDGTHR 547
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 272-306 5.45e-13

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 64.54  E-value: 5.45e-13
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1207179854  272 CMADQFRCMSGRCVRLSWRCDGEDDCSDGSDEEGC 306
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
72-107 6.82e-13

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 64.19  E-value: 6.82e-13
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1207179854   72 TCSPLDFHCENGKCIRRSWLCDGDNDCEDDSDEQDC 107
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 813-855 3.67e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 62.23  E-value: 3.67e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1207179854   813 EVVVDTSLESPAGLAIDWLTHKLYWTDAGTDRIEVSNTDGSMR 855
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1425-1467 7.79e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 61.46  E-value: 7.79e-12
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1207179854  1425 ETVISSGLKTTDGLAVDWVARNMYWTDTGRNTIEVAHLDGTSR 1467
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 272-303 1.16e-11

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 60.72  E-value: 1.16e-11
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1207179854   272 CMADQFRCMSGRCVRLSWRCDGEDDCSDGSDE 303
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 73-107 1.24e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 60.68  E-value: 1.24e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1207179854   73 CSPLDFHCENGKCIRRSWLCDGDNDCEDDSDEQDC 107
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
272-306 1.33e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 60.73  E-value: 1.33e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1207179854  272 CMADQFRCMSGRCVRLSWRCDGEDDCSDGSDEEGC 306
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 592-634 2.97e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 2.97e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1207179854   592 KIIADTHLFWPNGLTIDYASHRMYWVDAKHHVIERADLDGKNR 634
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 150-184 3.70e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.14  E-value: 3.70e-11
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1207179854  150 CSDKEFRCTDGSCIAEHWYCDGDSDCKDGTDEENC 184
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 568-609 5.59e-11

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 59.10  E-value: 5.59e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1207179854  568 GKIYWTDWGNMPRIEYANMDGSNRKIIADTHLFWPNGLTIDY 609
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1512-1552 6.43e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 58.77  E-value: 6.43e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1207179854  1512 KVLINTDLGWPNGLTLDYDTRRIFWVDAHLDRIESSDLNGK 1552
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
148-184 9.19e-11

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 58.41  E-value: 9.19e-11
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1207179854  148 RKCSDKEFRCTDGSCIAEHWYCDGDSDCKDGTDEENC 184
Cdd:pfam00057    1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 111-143 1.10e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 58.03  E-value: 1.10e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1207179854   111 ECEEDEFHCQNGYCIRSLWYCDGDNDCGDNSDE 143
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 233-267 1.22e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 1.22e-10
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1207179854  233 CRSAEFMCSSGMCINAGWRCDGEFDCDDQSDEKNC 267
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 112-144 1.23e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 57.99  E-value: 1.23e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1207179854  112 CEEDEFHCQNGYCIRSLWYCDGDNDCGDNSDEQ 144
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEE 33
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1488-1529 1.97e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 57.55  E-value: 1.97e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1207179854 1488 GFLFWTDWGHIAKIERAFLDGTDRKVLINTDLGWPNGLTLDY 1529
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1123-1163 2.23e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 57.23  E-value: 2.23e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1207179854  1123 IISTGLMTTDGLAVDSVGRKIYWTDTGTNRIEVANLNGSMR 1163
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1090-1282 2.39e-10

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 63.49  E-value: 2.39e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1090 AIGVDPiEGKVYWSDSTLKKISRSNINGTEHEDIISTGLMTTD-----GLAVDSVGRkIYWTDTGTNRIEVANLNGSMRK 1164
Cdd:cd05819     59 GVAVDS-DGNLYVADTGNHRIQKFDPDGNFLASFGGSGDGDGEfngprGIAVDSSGN-IYVADTGNHRIQKFDPDGEFLT 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1165 VL-----VWQNLDSPRAIALYHEmGYMYWTDWGEHaklerssmdgsdRVVLINNN----------------LGWPNGLAV 1223
Cdd:cd05819    137 TFgsggsGPGQFNGPTGVAVDSD-GNIYVADTGNH------------RIQVFDPDgnflttfgstgtgpgqFNYPTGIAV 203

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207179854 1224 DKAGSqLLWADAHTERIEASDLNGS------NRRTLVSPVQHPYGLTVLGS-HMYWTDWQSRSIHR 1282
Cdd:cd05819    204 DSDGN-IYVADSGNNRVQVFDPDGAgfggngNFLGSDGQFNRPSGLAVDSDgNLYVADTGNNRIQV 268
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 72-104 2.86e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.87  E-value: 2.86e-10
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1207179854    72 TCSPLDFHCENGKCIRRSWLCDGDNDCEDDSDE 104
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 901-942 3.26e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.84  E-value: 3.26e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1207179854   901 VIISSNLTWPNGLAIDYSTERLYWADASVKTIEYGNFDGSGR 942
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1011-1048 4.03e-10

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 56.48  E-value: 4.03e-10
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1207179854 1011 CLVNNGGCSHLCLlaPAPKSWSCACPTGINLQADGKTC 1048
Cdd:pfam14670    1 CSVNNGGCSHLCL--NTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
232-267 4.22e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.49  E-value: 4.22e-10
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1207179854  232 PCRSAEFMCSSGMCINAGWRCDGEFDCDDQSDEKNC 267
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 876-917 7.92e-10

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 55.63  E-value: 7.92e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1207179854  876 GFMYWTDWGANPKIERAGMDAWNRTVIISSNLTWPNGLAIDY 917
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
112-144 8.21e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 55.72  E-value: 8.21e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1207179854  112 CEEDEFHCQNGYCIRSLWYCDGDNDCGDNSDEQ 144
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEE 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 29-68 1.07e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 55.29  E-value: 1.07e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1207179854   29 CGKNHFTCAVSafgecTCIPAQWQCDGDNDCGDHSDEDGC 68
Cdd:cd00112      1 CPPNEFRCANG-----RCIPSSWVCDGEDDCGDGSDEENC 35
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1384-1543 1.44e-09

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 60.48  E-value: 1.44e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1384 VPVAELQNVISLDYDSVERKLYYTDVSLDVIRRVNLDGSDMETVISSGlKTTDGLAVDWVARNMYWTDTGRNTIEVahLD 1463
Cdd:COG3391     62 LGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSV--ID 138

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1464 GTSRKVLVNNSL-DEPRAIAVFPSKGFLFWTDWGH--IAKIERAFlDGTDRKVLINTDLG-WPNGLTLDYDTRRIFWVDA 1539
Cdd:COG3391    139 TATGKVVATIPVgAGPHGIAVDPDGKRLYVANSGSntVSVIVSVI-DTATGKVVATIPVGgGPVGVAVSPDGRRLYVANR 217


                   ....
gi 1207179854 1540 HLDR 1543
Cdd:COG3391    218 GSNT 221
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1318-1353 1.97e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 54.56  E-value: 1.97e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1207179854 1318 CGRRNGGCSHLCLPRLNGTSCACPTGVLLKADGRSC 1353
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 548-591 2.07e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 54.53  E-value: 2.07e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1207179854   548 KVLLWQRMEKPRAIALHPIEGKIYWTDWGNmPRIEYANMDGSNR 591
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 149-181 2.30e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.18  E-value: 2.30e-09
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1207179854   149 KCSDKEFRCTDGSCIAEHWYCDGDSDCKDGTDE 181
Cdd:smart00192    1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 233-264 3.67e-09

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 53.79  E-value: 3.67e-09
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1207179854   233 CRSAEFMCSSGMCINAGWRCDGEFDCDDQSDE 264
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 314-345 4.37e-09

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 53.36  E-value: 4.37e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1207179854  314 CAPDQFLCGNGRCIGQRKVCNDVKDCEDGTDE 345
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 473-660 5.14e-09

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 59.23  E-value: 5.14e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  473 IALDfhhSQELVFWSDVTLDRIMRASLNG----SNVEEVVSTGLESPGGLAIDwiHNKLYWTDSGTSRIEVSNLDGthRK 548
Cdd:cd14963     61 IAVD---SDGNIYVADLYNGRIQVFDPDGkflkYFPEKKDRVKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEG--KL 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  549 VLLWQRMEK-------PRAIALHPiEGKIYWTDWGNMpRIEYANMDGSNRKIIA-----DTHLFWPNGltIDYASH-RMY 615
Cdd:cd14963    134 LLEFGKPGSepgelsyPNGIAVDE-DGNIYVADSGNG-RIQVFDKNGKFIKELNgspdgKSGFVNPRG--IAVDPDgNLY 209

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1207179854  616 WVDAKHHVIERADLDGKNRKAVISQG-----LPHPFAITVFEDS-LYWTDW 660
Cdd:cd14963    210 VVDNLSHRVYVFDEQGKELFTFGGRGkddgqFNLPNGLFIDDDGrLYVTDR 260
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1468-1511 6.57e-09

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.99  E-value: 6.57e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1207179854  1468 KVLVNNSLDEPRAIAVFPSKGFLFWTDWGHiAKIERAFLDGTDR 1511
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGL-DVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 360-395 8.53e-09

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 52.63  E-value: 8.53e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1207179854  360 CNVNNGGCSQKCQMSRGLVQCTCHTGYTLTADGKTC 395
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1124-1293 1.29e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 57.78  E-value: 1.29e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1124 ISTGLMTTDGLAVDSVGRKIYWTDTGTNRIEVANLNgSMRKVLVWQNLDSPRAIALYHEMGYMYWTDWGEHAKlerSSMD 1203
Cdd:COG3391     63 GAAAVADADGADAGADGRRLYVANSGSGRVSVIDLA-TGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRV---SVID 138

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1204 GSDRVVLINNNLG-WPNGLAVDKAGSQLLWADAHTERIEA--SDLNGSNRRTL--VSPVQHPYGLTVL--GSHMYWTDWQ 1276
Cdd:COG3391    139 TATGKVVATIPVGaGPHGIAVDPDGKRLYVANSGSNTVSVivSVIDTATGKVVatIPVGGGPVGVAVSpdGRRLYVANRG 218

                          170
                   ....*....|....*..
gi 1207179854 1277 SrsiHRADKNTGENAII 1293
Cdd:COG3391    219 S---NTSNGGSNTVSVI 232
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1209-1250 1.56e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 52.22  E-value: 1.56e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1207179854  1209 VLINNNLGWPNGLAVDKAGSQLLWADAHTERIEASDLNGSNR 1250
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 314-345 1.69e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 51.87  E-value: 1.69e-08
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1207179854   314 CAPDQFLCGNGRCIGQRKVCNDVKDCEDGTDE 345
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1336-1608 1.81e-08

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 57.72  E-value: 1.81e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1336 TSCACPTGVLLKADGRscedlpetyLLFSNRVSVRRISLDTHDHTDVFVPVAELQNVISLDYDSvERKLYYTDVSLDVIR 1415
Cdd:COG4257     14 APGSGPRDVAVDPDGA---------VWFTDQGGGRIGRLDPATGEFTEYPLGGGSGPHGIAVDP-DGNLWFTDNGNNRIG 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1416 RVNLDGSDMETVISSGLKTTD-GLAVDwvARNMYW-TDTGRNTIevAHLDGTSRKVLVNNSLDE---PRAIAVFPsKGFL 1490
Cdd:COG4257     84 RIDPKTGEITTFALPGGGSNPhGIAFD--PDGNLWfTDQGGNRI--GRLDPATGEVTEFPLPTGgagPYGIAVDP-DGNL 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1491 FWTDWG--HIAKIERAflDGTDRKVLINTDLGWPNGLTLDYDTRrIFWVDA---HLDRIESSDlnGKLRQILIS-PVSHP 1564
Cdd:COG4257    159 WVTDFGanAIGRIDPD--TGTLTEYALPTPGAGPRGLAVDPDGN-LWVADTgsgRIGRFDPKT--GTVTEYPLPgGGARP 233

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 1207179854 1565 FALTqlkpvyspltpfsriSQQERWIYWTDWQTKSIQRVDKHTG 1608
Cdd:COG4257    234 YGVA---------------VDGDGRVWFAESGANRIVRFDPDTE 262
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 786-974 1.97e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 57.71  E-value: 1.97e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  786 LDSESFIYWTDVTTDSINRALWDGSKQEVVV-----DTSLESPAGLAIDwLTHKLYWTDAGTDRIEVSNTDGSMRTVL-- 858
Cdd:cd05819     62 VDSDGNLYVADTGNHRIQKFDPDGNFLASFGgsgdgDGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGEFLTTFgs 140

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  859 ---IWENLDRPRDIVVDPIGGFmYWTDWGANpKIER-----AGMDAWNRTVIISSNLTWPNGLAIDySTERLYWADAS-- 928
Cdd:cd05819    141 ggsGPGQFNGPTGVAVDSDGNI-YVADTGNH-RIQVfdpdgNFLTTFGSTGTGPGQFNYPTGIAVD-SDGNIYVADSGnn 217

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1207179854  929 ---VKTIEYGNFDGSGRQVLIGSQLPHPFGLTLHED-RIYWTDWQSKSIQ 974
Cdd:cd05819    218 rvqVFDPDGAGFGGNGNFLGSDGQFNRPSGLAVDSDgNLYVADTGNNRIQ 267
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 787-974 2.38e-08

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 57.21  E-value: 2.38e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  787 DSESFIYWTDVTTDSINRALWDGSKQEVVVDTSlESPAGLAID-----WLT---HKLYWTDAGTDRIEVSNTDGSMRtvl 858
Cdd:COG3386     16 DPDGRLYWVDIPGGRIHRYDPDGGAVEVFAEPS-GRPNGLAFDpdgrlLVAdhgRGLVRFDPADGEVTVLADEYGKP--- 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  859 iwenLDRPRDIVVDPIGGFmYWTD---WGANPKIERagMDAWNRTVIISSNLTWPNGLAIDYSTERLYWADASVKTIEYG 935
Cdd:COG3386     92 ----LNRPNDGVVDPDGRL-YFTDmgeYLPTGALYR--VDPDGSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRIYRF 164

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1207179854  936 NFDGSG----RQVLIGSQLPHPF--GLTLHED-RIYWTDWQSKSIQ 974
Cdd:COG3386    165 DLDADGtlgnRRVFADLPDGPGGpdGLAVDADgNLWVALWGGGGVV 210
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1043-1239 2.95e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 56.63  E-value: 2.95e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1043 ADGKTCAHAMNSFLVFARRTDIRMISLDIPYFADVVLAVNTSMKNTIAIGVDPIEGK-VYWSDSTLKKISRSNINGTEHE 1121
Cdd:COG3391     24 AVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRrLYVANSGSGRVSVIDLATGKVV 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1122 DIISTGlMTTDGLAVDSVGRKIYWTDTGTNRIEVANLNgSMRKVLVWQNLDSPRAIALYHEMGYMYWTDWGEH--AKLEr 1199
Cdd:COG3391    104 ATIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSVIDTA-TGKVVATIPVGAGPHGIAVDPDGKRLYVANSGSNtvSVIV- 180

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1207179854 1200 SSMDGSDRVVLINNNLG-WPNGLAVDKAGSQLLWADAHTER 1239
Cdd:COG3391    181 SVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYVANRGSNT 221
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1141-1181 3.20e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 51.01  E-value: 3.20e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1207179854 1141 RKIYWTDTGT-NRIEVANLNGSMRKVLVWQNLDSPRAIALYH 1181
Cdd:pfam00058    1 GRLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 473-624 4.41e-08

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 56.56  E-value: 4.41e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  473 IALDfhhSQELVFWSDVTLDRIMRASLNGSNVEEVVSTG-----LESPGGLAIDwIHNKLYWTDSGTSRIEVSNLDGThr 547
Cdd:cd05819    107 IAVD---SSGNIYVADTGNHRIQKFDPDGEFLTTFGSGGsgpgqFNGPTGVAVD-SDGNIYVADTGNHRIQVFDPDGN-- 180

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  548 KVLLW-------QRMEKPRAIALHPiEGKIYWTDWGNMpRIEYANMDGSNR-----KIIADTHLFWPNGLTIDyASHRMY 615
Cdd:cd05819    181 FLTTFgstgtgpGQFNYPTGIAVDS-DGNIYVADSGNN-RVQVFDPDGAGFggngnFLGSDGQFNRPSGLAVD-SDGNLY 257


                   ....*....
gi 1207179854  616 WVDAKHHVI 624
Cdd:cd05819    258 VADTGNNRI 266
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 705-739 5.07e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 50.32  E-value: 5.07e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1207179854  705 CGSNNGGCSHLCLPSNKTYTCVCPTGFR-KLDQHNC 739
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYElQDDGRTC 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 857-899 5.95e-08

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 50.29  E-value: 5.95e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1207179854   857 VLIWENLDRPRDIVVDPIGGFMYWTDWGaNPKIERAGMDAWNR 899
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 29-65 7.33e-08

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 49.94  E-value: 7.33e-08
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1207179854    29 CGKNHFTCAVSafgecTCIPAQWQCDGDNDCGDHSDE 65
Cdd:smart00192    2 CPPGEFQCDNG-----RCIPSSWVCDGVDDCGDGSDE 33
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
766-987 9.10e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 55.09  E-value: 9.10e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  766 LDAVIPLADVRNAVALDWDSLDSESFIYWTDVTTDSINRALWDGSKQEVVVDTSLESPAGLAIDWLT-----HKLYWTDA 840
Cdd:COG3391      8 LVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADagadgRRLYVANS 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  841 GTDRIEVSNTDgSMRTVLIWENLDRPRDIVVDPIGGFMYWTDWGANpKIerAGMDAWNRTVIISSNL-TWPNGLAIDYST 919
Cdd:COG3391     88 GSGRVSVIDLA-TGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNG-RV--SVIDTATGKVVATIPVgAGPHGIAVDPDG 163

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  920 ERLYWADASVKTI-----EygnFDGSGRQVL----IGSqlpHPFGLTLHED--RIYWTDWQS-KSIQSADKLTGLDRKTL 987
Cdd:COG3391    164 KRLYVANSGSNTVsvivsV---IDTATGKVVatipVGG---GPVGVAVSPDgrRLYVANRGSnTSNGGSNTVSVIDLATL 237
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1081-1120 1.80e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 49.14  E-value: 1.80e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1207179854  1081 VNTSMKNTIAIGVDPIEGKVYWSDSTLKKISRSNINGTEH 1120
Cdd:smart00135    4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
29-68 2.07e-07

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.78  E-value: 2.07e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1207179854   29 CGKNHFTCAVSafgecTCIPAQWQCDGDNDCGDHSDEDGC 68
Cdd:pfam00057    3 CSPNEFQCGSG-----ECIPRSWVCDGDPDCGDGSDEENC 37
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1445-1485 2.34e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.70  E-value: 2.34e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1207179854 1445 RNMYWTDTG-RNTIEVAHLDGTSRKVLVNNSLDEPRAIAVFP 1485
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 473-690 2.44e-07

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 54.25  E-value: 2.44e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  473 IALDFHHSqelVFWSDVTLDRIMRASLNGSNVEEVVSTG-----LESPGGLAIDwIHNKLYWTDSGTSRIEVSNLDGTHR 547
Cdd:cd05819     13 IAVDSSGN---IYVADTGNNRIQVFDPDGNFITSFGSFGsgdgqFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFL 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  548 KVLL-----WQRMEKPRAIALHPiEGKIYWTDWGNMpRIEYANMDGSNRKII-----ADTHLFWPNGLTIDyASHRMYWV 617
Cdd:cd05819     89 ASFGgsgdgDGEFNGPRGIAVDS-SGNIYVADTGNH-RIQKFDPDGEFLTTFgsggsGPGQFNGPTGVAVD-SDGNIYVA 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  618 DAKHHVIERADLDGKNRKAVISQGLP-----HPFAITVFED-SLYWTDWHTKSInsaNKFTGKNQEVIRN--------KL 683
Cdd:cd05819    166 DTGNHRIQVFDPDGNFLTTFGSTGTGpgqfnYPTGIAVDSDgNIYVADSGNNRV---QVFDPDGAGFGGNgnflgsdgQF 242


                   ....*..
gi 1207179854  684 HFPMDIH 690
Cdd:cd05819    243 NRPSGLA 249
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 613-652 2.63e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.70  E-value: 2.63e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1207179854  613 RMYWVDAK-HHVIERADLDGKNRKAVISQGLPHPFAITVFE 652
Cdd:pfam00058    2 RLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 834-873 3.33e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 48.31  E-value: 3.33e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1207179854  834 KLYWTDAGTD-RIEVSNTDGSMRTVLIWENLDRPRDIVVDP 873
Cdd:pfam00058    2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 785-974 5.95e-07

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 53.06  E-value: 5.95e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  785 SLDSESFIYWTDVTTDSINRALWDGSKQEVVVDTS----LESPAGLAIDwlTHKLYWTDAGTDRIEVSNTDGSMrtVLIW 860
Cdd:cd14963     62 AVDSDGNIYVADLYNGRIQVFDPDGKFLKYFPEKKdrvkLISPAGLAID--DGKLYVSDVKKHKVIVFDLEGKL--LLEF 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  861 -------ENLDRPRDIVVDPiGGFMYWTDWGaNPKI-----ERAGMDAWNRTVIISSNLTWPNGLAIDySTERLYWADAS 928
Cdd:cd14963    138 gkpgsepGELSYPNGIAVDE-DGNIYVADSG-NGRIqvfdkNGKFIKELNGSPDGKSGFVNPRGIAVD-PDGNLYVVDNL 214

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1207179854  929 VKTIEYGNFDG-----SGRQVLIGSQLPHPFGLTLHED-RIYWTDWQSKSIQ 974
Cdd:cd14963    215 SHRVYVFDEQGkelftFGGRGKDDGQFNLPNGLFIDDDgRLYVTDRENNRVA 266
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 525-565 1.09e-06

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 46.77  E-value: 1.09e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1207179854  525 NKLYWTDSGTS-RIEVSNLDGTHRKVLLWQRMEKPRAIALHP 565
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1092-1253 1.83e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 51.52  E-value: 1.83e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1092 GVDPIEGKVYWSDSTLKKISRSNINGTE-----HEDIISTGLMTTDGLAVDSVGrKIYWTDTGTNRIEVANLNGSMRKVL 1166
Cdd:cd14963     14 GVAVSDGRIYVADTNNHRVQVFDYEGKFkksfgGPGTGPGEFKYPYGIAVDSDG-NIYVADLYNGRIQVFDPDGKFLKYF 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1167 VWQ----NLDSPRAIALYHemGYMYWTDWGEHA--------KLERS-SMDGSDRvvlinNNLGWPNGLAVDKAGsQLLWA 1233
Cdd:cd14963     93 PEKkdrvKLISPAGLAIDD--GKLYVSDVKKHKvivfdlegKLLLEfGKPGSEP-----GELSYPNGIAVDEDG-NIYVA 164

                          170       180
                   ....*....|....*....|
gi 1207179854 1234 DAHTERIEASDLNGSNRRTL 1253
Cdd:cd14963    165 DSGNGRIQVFDKNGKFIKEL 184
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
313-345 2.07e-06

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 46.09  E-value: 2.07e-06
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1207179854  313 PCAPDQFLCGNGRCIGQRKVCNDVKDCEDGTDE 345
Cdd:pfam00057    2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
397-436 3.27e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 3.27e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1207179854   397 DVDECADDGYCSQG--CTNIEGGFQCWCVQGYElrpDKRSCK 436
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGYT---DGRNCE 39
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1164-1207 3.58e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 45.29  E-value: 3.58e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1207179854  1164 KVLVWQNLDSPRAIALYHEMGYMYWTDWGeHAKLERSSMDGSDR 1207
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 462-504 3.76e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 45.29  E-value: 3.76e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1207179854   462 YTLLLSNLENAIALDFHHSQELVFWSDVTLDRIMRASLNGSNV 504
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1077-1160 4.84e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 50.28  E-value: 4.84e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1077 VVLAVNTSMKNTIAIGVDPiEGKVYWSDSTLKKISRSNINGtEHEDIISTGLMTTD--GLAVDSVGRKIYWTDTGTNRIE 1154
Cdd:cd14962     48 IGNAGPNRFVSPIGVAIDA-NGNLYVSDAELGKVFVFDRDG-KFLRAIGAGALFKRptGIAVDPAGKRLYVVDTLAHKVK 125


                   ....*.
gi 1207179854 1155 VANLNG 1160
Cdd:cd14962    126 VFDLDG 131
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 1126-1228 5.53e-06

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 49.90  E-value: 5.53e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1126 TGLMTTDGLAVDSVGrKIYWTDTGTNRIEVANLNGSMRKVLVWQNLDSPRAIALYHEmGYMYWTDWGEH--AKLERSSmd 1203
Cdd:cd14952    133 TGLSNPDGVAVDGAG-NVYVTDTGNNRVLKLAAGSTTQTVLPFTGLNSPSGVAVDTA-GNVYVTDHGNNrvLKLAAGS-- 208

                           90       100
                   ....*....|....*....|....*
gi 1207179854 1204 gSDRVVLINNNLGWPNGLAVDKAGS 1228
Cdd:cd14952    209 -TTPTVLPFTGLNGPLGVAVDAAGN 232
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 820-974 5.76e-06

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 49.97  E-value: 5.76e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  820 LESPAGLAIDwLTHKLYWTDAGTDRIEVSNTDGSMRTvlIWEN-------LDRPRDIVVDPiGGFMYWTDWGaNPKIER- 891
Cdd:cd14956     59 FGRPRGLAVD-KDGWLYVADYWGDRIQVFTLTGELQT--IGGSsgsgpgqFNAPRGVAVDA-DGNLYVADFG-NQRIQKf 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  892 --AG--MDAWNRTVIISSNLTWPNGLAIDySTERLYWADAsvktieYGN----FDGSGRQVL-IGS------QLPHPFGL 956
Cdd:cd14956    134 dpDGsfLRQWGGTGIEPGSFNYPRGVAVD-PDGTLYVADT------YNDriqvFDNDGAFLRkWGGrgtgpgQFNYPYGI 206

                          170
                   ....*....|....*....
gi 1207179854  957 TLHED-RIYWTDWQSKSIQ 974
Cdd:cd14956    207 AIDPDgNVFVADFGNNRIQ 225
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 817-974 6.13e-06

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 50.01  E-value: 6.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  817 DTSLESPAGLAIDwLTHKLYWTDAGTDRIEVSNTDGsmRTVLIW-------ENLDRPRDIVVDPiGGFMYWTDWGANpKI 889
Cdd:cd05819      4 PGELNNPQGIAVD-SSGNIYVADTGNNRIQVFDPDG--NFITSFgsfgsgdGQFNEPAGVAVDS-DGNLYVADTGNH-RI 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  890 ERAGMDAWNRTVIISS-----NLTWPNGLAIDySTERLYWADASVKTIEYgnFDGSGR-QVLIGS------QLPHPFGLT 957
Cdd:cd05819     79 QKFDPDGNFLASFGGSgdgdgEFNGPRGIAVD-SSGNIYVADTGNHRIQK--FDPDGEfLTTFGSggsgpgQFNGPTGVA 155

                          170
                   ....*....|....*...
gi 1207179854  958 LH-EDRIYWTDWQSKSIQ 974
Cdd:cd05819    156 VDsDGNIYVADTGNHRIQ 173
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1091-1212 6.91e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 49.31  E-value: 6.91e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1091 IGVDPIEGKVYWSDSTLKKISRSNINGTEHEDIISTGLMTTdGLAVDSVGRKIYWTDTGTNRI----EVANLNgSMRKVL 1166
Cdd:COG3391    115 LAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGPH-GIAVDPDGKRLYVANSGSNTVsvivSVIDTA-TGKVVA 192

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1207179854 1167 VWQNLDSPRAIALYHEMGYMYWTDWGEHaklerSSMDGSDRVVLIN 1212
Cdd:COG3391    193 TIPVGGGPVGVAVSPDGRRLYVANRGSN-----TSNGGSNTVSVID 233
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1638-1662 6.94e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.54  E-value: 6.94e-06
                           10        20
                   ....*....|....*....|....*
gi 1207179854 1638 CAANNGGCTHLCLARSNSFICACPD 1662
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPE 25
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1404-1551 7.08e-06

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 49.62  E-value: 7.08e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1404 LYYTDVSLDVIRRVNLDGSDMETVISSGLKTTD-----GLAVD-----WVArnmywtDTGRNTIEVAHLDGTSRKVL--- 1470
Cdd:cd05819     68 LYVADTGNHRIQKFDPDGNFLASFGGSGDGDGEfngprGIAVDssgniYVA------DTGNHRIQKFDPDGEFLTTFgsg 141

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1471 --VNNSLDEPRAIAVFPSkGFLFWTDWGH--IAKI--ERAFLDGTDRKVLINTDLGWPNGLTLDYDTrRIFWVDAHLDRI 1544
Cdd:cd05819    142 gsGPGQFNGPTGVAVDSD-GNIYVADTGNhrIQVFdpDGNFLTTFGSTGTGPGQFNYPTGIAVDSDG-NIYVADSGNNRV 219


                   ....*..
gi 1207179854 1545 ESSDLNG 1551
Cdd:cd05819    220 QVFDPDG 226
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1445-1608 8.15e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 49.31  E-value: 8.15e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1445 RNMYWTDTGRNTIEVahLDGTSRKVLVNNSL-DEPRAIAVFPSKGFLFWTDW--GHIAKIeraflDGTDRKVLINTDLG- 1520
Cdd:COG3391     80 RRLYVANSGSGRVSV--IDLATGKVVATIPVgGGPRGLAVDPDGGRLYVADSgnGRVSVI-----DTATGKVVATIPVGa 152

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1521 WPNGLTLDYDTRRIFWVDAHLDRIessdlngklrQILISPVShPFALTQLKPVYSPLTPFS-RISQQERWIY-------W 1592
Cdd:COG3391    153 GPHGIAVDPDGKRLYVANSGSNTV----------SVIVSVID-TATGKVVATIPVGGGPVGvAVSPDGRRLYvanrgsnT 221

                          170
                   ....*....|....*.
gi 1207179854 1593 TDWQTKSIQRVDKHTG 1608
Cdd:COG3391    222 SNGGSNTVSVIDLATL 237
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 1093-1282 1.14e-05

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 49.12  E-value: 1.14e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1093 VDPiEGKVYWSDSTLKKISRSNINGTEHEDIISTGLMTTdGLAVDSVGR--------KIYWTDTGTNRIEV-ANLNGsmr 1163
Cdd:COG3386     15 WDP-DGRLYWVDIPGGRIHRYDPDGGAVEVFAEPSGRPN-GLAFDPDGRllvadhgrGLVRFDPADGEVTVlADEYG--- 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1164 kvlvwQNLDSPRAIALyHEMGYMYWTD---WGEHAKLERssMDGSDRVVLINNNLGWPNGLAVDKAGSQLLWADAHTERI 1240
Cdd:COG3386     90 -----KPLNRPNDGVV-DPDGRLYFTDmgeYLPTGALYR--VDPDGSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRI 161

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1241 EASDLNG----SNRRTLVSPVQH---PYGLTVLGSHMYW-TDWQSRSIHR 1282
Cdd:COG3386    162 YRFDLDAdgtlGNRRVFADLPDGpggPDGLAVDADGNLWvALWGGGGVVR 211
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1389-1423 1.16e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 44.13  E-value: 1.16e-05
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1207179854  1389 LQNVISLDYDSVERKLYYTDVSLDVIRRVNLDGSD 1423
Cdd:smart00135    8 LGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 397-429 1.49e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.49e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1207179854  397 DVDECADDGYCSQG--CTNIEGGFQCWCVQGYELR 429
Cdd:cd00054      1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGYTGR 35
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
484-638 1.50e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 48.54  E-value: 1.50e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  484 VFWSDVTLDRIMRASLNGSNVEEVVSTGlESPGGLAIDWIHNKLYWTDSGTSRIEVsnLDGTHRKVLlwQRM---EKPRA 560
Cdd:COG3391     82 LYVANSGSGRVSVIDLATGKVVATIPVG-GGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVV--ATIpvgAGPHG 156

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  561 IALHPIEGKIYWTDWGN--MPRIEYAnMDGSNRKIIADTHL-FWPNGLTIDYASHRMYWVDAKHHvieRADLDGkNRKAV 637
Cdd:COG3391    157 IAVDPDGKRLYVANSGSntVSVIVSV-IDTATGKVVATIPVgGGPVGVAVSPDGRRLYVANRGSN---TSNGGS-NTVSV 231


                   .
gi 1207179854  638 I 638
Cdd:COG3391    232 I 232
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 379-400 1.52e-05

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 43.17  E-value: 1.52e-05
                           10        20
                   ....*....|....*....|..
gi 1207179854  379 QCTCHTGYTLTADGKTCRDVDE 400
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 505-659 2.12e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 48.35  E-value: 2.12e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  505 EEVVSTGLESPGGLAIDWiHNKLYWTDSGTSRIEVSNLDGthRKVLLW-----QRMEKPRAIALHPiEGKIYWTDWGNmP 579
Cdd:cd14962      4 EERPKEALTRPYGVAADG-RGRIYVADTGRGAVFVFDLPN--GKVFVIgnagpNRFVSPIGVAIDA-NGNLYVSDAEL-G 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  580 RIEYANMDGSNRKIIADTHLFW-PNGLTIDYASHRMYWVDAKHHVIERADLDGKNRKAVISQG-----LPHPFAITVF-E 652
Cdd:cd14962     79 KVFVFDRDGKFLRAIGAGALFKrPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDIGKRGsgpgeFNLPTDLAVDrD 158


                   ....*..
gi 1207179854  653 DSLYWTD 659
Cdd:cd14962    159 GNLYVTD 165
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 1133-1265 2.35e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 48.08  E-value: 2.35e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1133 GLAVDSVGrKIYWTDTGTNRIEVANLNGsmRKVLVWQ-------NLDSPRAIALyHEMGYMYWTDWGEHAkLERSSMDGS 1205
Cdd:cd05819     12 GIAVDSSG-NIYVADTGNNRIQVFDPDG--NFITSFGsfgsgdgQFNEPAGVAV-DSDGNLYVADTGNHR-IQKFDPDGN 86

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1207179854 1206 DRVVLINN-----NLGWPNGLAVDKAGSqlLW-ADAHTERIEASDLNGSNRRTLVSPV------QHPYGLTV 1265
Cdd:cd05819     87 FLASFGGSgdgdgEFNGPRGIAVDSSGN--IYvADTGNHRIQKFDPDGEFLTTFGSGGsgpgqfNGPTGVAV 156
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 943-984 2.43e-05

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 42.97  E-value: 2.43e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1207179854   943 QVLIGSQLPHPFGLTLH--EDRIYWTDWQSKSIQSADkLTGLDR 984
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDwiEGRLYWTDWGLDVIEVAN-LDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 403-435 2.44e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 43.00  E-value: 2.44e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1207179854  403 DDGYCSQGCTNIEGGFQCWCVQGYELRPDKRSC 435
Cdd:pfam14670    4 NNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 513-632 4.79e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 47.28  E-value: 4.79e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  513 ESPGGLAIDWIHNkLYWTDSGTSRIEVSNLDGTHRKVlLWQR------MEKPRAIALHPiEGKIYWTD-WGNmpRIEYAN 585
Cdd:cd14956     13 KDPRGIAVDADDN-VYVADARNGRIQVFDKDGTFLRR-FGTTgdgpgqFGRPRGLAVDK-DGWLYVADyWGD--RIQVFT 87

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1207179854  586 MDGSNRKII-----ADTHLFWPNGLTIDyASHRMYWVDAKHHVIERADLDGK 632
Cdd:cd14956     88 LTGELQTIGgssgsGPGQFNAPRGVAVD-ADGNLYVADFGNQRIQKFDPDGS 138
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 511-653 4.83e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 47.29  E-value: 4.83e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  511 GLESPGGLAIDWihNKLYWTDSGTSRIEVSNLDGTHRKVLLWQRMEK-----PRAIALHPiEGKIYWTDWGNmPRIEYAN 585
Cdd:cd14963      8 PLNKPMGVAVSD--GRIYVADTNNHRVQVFDYEGKFKKSFGGPGTGPgefkyPYGIAVDS-DGNIYVADLYN-GRIQVFD 83

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207179854  586 MDGSNRKIIADT----HLFWPNGLTIDyaSHRMYWVDAKHHVIERADLDGKNRKAVISQG-----LPHPFAITVFED 653
Cdd:cd14963     84 PDGKFLKYFPEKkdrvKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEGKLLLEFGKPGsepgeLSYPNGIAVDED 158
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1133-1289 5.77e-05

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 46.94  E-value: 5.77e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1133 GLAVDSVGRkIYWTDTGTNRIEVANL-NGSMRKVlVWQNLDSPRAIALYHEmGYMYWTDWGEHA---------KLERSSM 1202
Cdd:COG4257     21 DVAVDPDGA-VWFTDQGGGRIGRLDPaTGEFTEY-PLGGGSGPHGIAVDPD-GNLWFTDNGNNRigridpktgEITTFAL 97

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1203 DGSDRVvlinnnlgwPNGLAVDKAGSqlLW-ADAHTERIEASDLNGSNRRTLVSPVQH--PYGLTV--LGShMYWTDWQS 1277
Cdd:COG4257     98 PGGGSN---------PHGIAFDPDGN--LWfTDQGGNRIGRLDPATGEVTEFPLPTGGagPYGIAVdpDGN-LWVTDFGA 165

                          170
                   ....*....|..
gi 1207179854 1278 RSIHRADKNTGE 1289
Cdd:COG4257    166 NAIGRIDPDTGT 177
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1071-1240 6.85e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 46.90  E-value: 6.85e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1071 IPYFADVVLAVNTSMKNTIAIgvdpIEGKVYWSDSTLKKISRSNINGTEHEDIISTG-----LMTTDGLAVDSVGRkIYW 1145
Cdd:cd14963     89 LKYFPEKKDRVKLISPAGLAI----DDGKLYVSDVKKHKVIVFDLEGKLLLEFGKPGsepgeLSYPNGIAVDEDGN-IYV 163

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1146 TDTGTNRIEVANLNGSMRKVL-----VWQNLDSPRAIAlYHEMGYMYWTDWGEH-------AKLERSSMDGSDrvvLINN 1213
Cdd:cd14963    164 ADSGNGRIQVFDKNGKFIKELngspdGKSGFVNPRGIA-VDPDGNLYVVDNLSHrvyvfdeQGKELFTFGGRG---KDDG 239

                          170       180
                   ....*....|....*....|....*..
gi 1207179854 1214 NLGWPNGLAVDKAGsQLLWADAHTERI 1240
Cdd:cd14963    240 QFNLPNGLFIDDDG-RLYVTDRENNRV 265
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 1126-1228 9.58e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 46.05  E-value: 9.58e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1126 TGLMTTDGLAVDSVGrKIYWTDTGTNRIEVANLNGSMRKVLVWQNLDSPRAIALyHEMGYMYWTDWGEH--AKLERSSmd 1203
Cdd:cd14952     91 TGLNDPTGVAVDAAG-NVYVADTGNNRVLKLAAGSNTQTVLPFTGLSNPDGVAV-DGAGNVYVTDTGNNrvLKLAAGS-- 166

                           90       100
                   ....*....|....*....|....*
gi 1207179854 1204 gSDRVVLINNNLGWPNGLAVDKAGS 1228
Cdd:cd14952    167 -TTQTVLPFTGLNSPSGVAVDTAGN 190
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 635-675 1.19e-04

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 41.05  E-value: 1.19e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1207179854   635 KAVISQGLPHP--FAITVFEDSLYWTDWHTKSINSANkFTGKN 675
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN-LDGTN 42
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 1094-1273 1.36e-04

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 45.72  E-value: 1.36e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1094 DPIEGKVYWSDSTLKKISRSNINGTEHEDI-----ISTGLMTTDGLAVDSVGRKIYWTDTGTNRIEV-----------AN 1157
Cdd:pfam08450    8 DEEEGALYWVDILGGRIHRLDPATGKETVWdtpgpVGAIAPRDDGGLIVALKDGVALLDLATGELTPladpedddwplNR 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1158 LN------------GSMRKvlvwqNLDSPRAI-ALYHemgymywtdwgehaklerssMDGSDRVVLINNNLGWPNGLAVD 1224
Cdd:pfam08450   88 FNdgkvdpdgrfwfGTMGD-----DEAPGGDPgALYR--------------------LDPDGKLTRVLDGLTISNGLAWS 142

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1207179854 1225 KAGSQLLWADAHTERIEASDLNG-----SNRRTLVSPVQH---PYGLTVLGSHMYWT 1273
Cdd:pfam08450  143 PDGRTLYFADSPARKIWAYDYDLdggliSNRRVFADFKPGlgrPDGMAVDAEGNVWV 199
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 360-395 1.64e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 40.66  E-value: 1.64e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1207179854  360 CNVNNGGCSQK--CQMSRGLVQCTCHTGYTLtaDGKTC 395
Cdd:pfam12947    1 CSDNNGGCHPNatCTNTGGSFTCTCNDGYTG--DGVTC 36
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1133-1247 1.65e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 45.66  E-value: 1.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1133 GLAVDSVGRkIYWTDTGTNRIEVANLNGsmRKVLVW-----QNLDSPRAIALyHEMGYMYWTDwGEHAKLERssMDGSDR 1207
Cdd:cd14962     16 GVAADGRGR-IYVADTGRGAVFVFDLPN--GKVFVIgnagpNRFVSPIGVAI-DANGNLYVSD-AELGKVFV--FDRDGK 88

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1207179854 1208 VV-LINNNLGW--PNGLAVDKAGSQLLWADAHTERIEASDLNG 1247
Cdd:cd14962     89 FLrAIGAGALFkrPTGIAVDPAGKRLYVVDTLAHKVKVFDLDG 131
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 1402-1442 2.34e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 40.22  E-value: 2.34e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1207179854 1402 RKLYYTDVSLD-VIRRVNLDGSDMETVISSGLKTTDGLAVDW 1442
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 812-967 6.92e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 43.35  E-value: 6.92e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  812 QEVVVDTSLESPAGLAIDwLTHKLYWTDAGTDRIeVSNTDGSMR-TVLIWENLDRPRDIVVDPIGGfMYWTDWGANPKIE 890
Cdd:cd14952      1 QTVLPFTGLDGPGGVAVD-AAGNVYVADSGNNRV-LKLAAGSTTqTVLPFTGLYQPQGVAVDAAGT-VYVTDFGNNRVLK 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  891 RAGmDAWNRTVIISSNLTWPNGLAIDySTERLYWADasvktieYGN------FDGSGRQ-VLIGSQLPHPFGLTLH-EDR 962
Cdd:cd14952     78 LAA-GSTTQTVLPFTGLNDPTGVAVD-AAGNVYVAD-------TGNnrvlklAAGSNTQtVLPFTGLSNPDGVAVDgAGN 148


                   ....*
gi 1207179854  963 IYWTD 967
Cdd:cd14952    149 VYVTD 153
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 791-830 7.05e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 39.07  E-value: 7.05e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1207179854  791 FIYWTDVTTD-SINRALWDGSKQEVVVDTSLESPAGLAIDW 830
Cdd:pfam00058    2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 961-1001 7.55e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 38.68  E-value: 7.55e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1207179854  961 DRIYWTDWQSKSIQSADKLTGLDRKTL-AENLENLMDIHMFH 1001
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLfTDDLQHPNAIAVDP 42
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
 498-544 8.03e-04

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 44.46  E-value: 8.03e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1207179854  498 SLNGSNVEEVVSTGLESPGGLAIDWIHNKLYWTDSGTSRIEVSNLDG 544
Cdd:PLN02919   553 SLEKDNDPRLLTSPLKFPGKLAIDLLNNRLFISDSNHNRIVVTDLDG 599
EGF_CA pfam07645
Calcium-binding EGF domain;
397-425 9.07e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.37  E-value: 9.07e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1207179854  397 DVDECADDGY-CSQG--CTNIEGGFQCWCVQG 425
Cdd:pfam07645    1 DVDECATGTHnCPANtvCVNTIGSFECRCPDG 32
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 482-522 9.66e-04

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 38.68  E-value: 9.66e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1207179854  482 ELVFWSDVTLD-RIMRASLNGSNVEEVVSTGLESPGGLAIDW 522
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 1133-1248 1.27e-03

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 42.92  E-value: 1.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1133 GLAVDSVGRkIYWTDTGTNRIEVANLNGS-MRKVLV----WQNLDSPRAIALYHEmGYMYWTDWGEHaklerssmdgsdR 1207
Cdd:cd14954    122 GVAVDSEGR-IYVSDTRNHRVQVFDSDGQfIRKFGFegagPGQLDSPRGVAVNPD-GNIVVSDFNNH------------R 187

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1207179854 1208 VVLINNN------LG----------WPNGLAVDKAGSQLLwADAHTERIEASDLNGS 1248
Cdd:cd14954    188 LQVFDPDgqflrfFGsegsgngqfkRPRGVAVDDEGNIIV-ADSGNHRVQVFSPDGE 243
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 1250-1289 1.44e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.97  E-value: 1.44e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1207179854  1250 RRTLVSPVQHPYGLTV--LGSHMYWTDWQSRSIHRADKNTGE 1289
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVANLDGTN 42
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 477-630 1.66e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 42.57  E-value: 1.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  477 FHHSQELvFWSDVTLDRIMRASLNGSNVEEVVSTGlESPGGLAIDWiHNKLYWTDSGtSRIEVSNLDGTHRKVLLWQ--- 553
Cdd:COG3386     15 WDPDGRL-YWVDIPGGRIHRYDPDGGAVEVFAEPS-GRPNGLAFDP-DGRLLVADHG-RGLVRFDPADGEVTVLADEygk 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  554 RMEKPRAIALHPiEGKIYWTDwgnmPRIEYAN-----MDGSNRKIIADTHLFWPNGLTIDYASHRMYWVDAKHHVIERAD 628
Cdd:COG3386     91 PLNRPNDGVVDP-DGRLYFTD----MGEYLPTgalyrVDPDGSLRVLADGLTFPNGIAFSPDGRTLYVADTGAGRIYRFD 165


                   ..
gi 1207179854  629 LD 630
Cdd:COG3386    166 LD 167
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 768-945 1.98e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 42.19  E-value: 1.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  768 AVIPLADVRNAVALdwdSLDSESFIYWTDVTTdsiNR--ALWDGSKQEVVVD-TSLESPAGLAIDwlTH-KLYWTDAGTD 843
Cdd:cd14952     86 TVLPFTGLNDPTGV---AVDAAGNVYVADTGN---NRvlKLAAGSNTQTVLPfTGLSNPDGVAVD--GAgNVYVTDTGNN 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  844 RIEVSNTDGSMRTVLIWENLDRPRDIVVDPIGGfMYWTDWGANPKIE-RAGMDAwnRTVIISSNLTWPNGLAIDysterl 922
Cdd:cd14952    158 RVLKLAAGSTTQTVLPFTGLNSPSGVAVDTAGN-VYVTDHGNNRVLKlAAGSTT--PTVLPFTGLNGPLGVAVD------ 228

                          170       180
                   ....*....|....*....|...
gi 1207179854  923 ywADASVKTIEYGNfdgsgRQVL 945
Cdd:cd14952    229 --AAGNVYVADRGN-----DRVV 244
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 1126-1274 2.29e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 41.81  E-value: 2.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1126 TGLMTTDGLAVDSVGrKIYWTDTGTNRIeVANLNGSMR-KVLVWQNLDSPRAIALYHEmGYMYWTDWGEHAKLERSSmDG 1204
Cdd:cd14952      7 TGLDGPGGVAVDAAG-NVYVADSGNNRV-LKLAAGSTTqTVLPFTGLYQPQGVAVDAA-GTVYVTDFGNNRVLKLAA-GS 82

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1207179854 1205 SDRVVLINNNLGWPNGLAVDKAGSqLLWADAHTERIEASDlNGSNRRTLV--SPVQHPYGLTVLGSHM-YWTD 1274
Cdd:cd14952     83 TTQTVLPFTGLNDPTGVAVDAAGN-VYVADTGNNRVLKLA-AGSNTQTVLpfTGLSNPDGVAVDGAGNvYVTD 153
SGL pfam08450
SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in ...
 793-932 2.46e-03

SMP-30/Gluconolactonase/LRE-like region; This family describes a region that is found in proteins expressed by a variety of eukaryotic and prokaryotic species. These proteins include various enzymes, such as senescence marker protein 30 (SMP-30), gluconolactonase and luciferin-regenerating enzyme (LRE). SMP-30 is known to hydrolyse diisopropyl phosphorofluoridate in the liver, and has been noted as having sequence similarity, in the region described in this family, with PON1 and LRE.


Pssm-ID: 462480 [Multi-domain]  Cd Length: 246  Bit Score: 41.86  E-value: 2.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  793 YWTDVTTDSINRaLWDGSKQEVVVDTSleSPAGLAIDWLTHKLYWTDAgtDRIEVSNTDGSMRTVLIWENLD-----RPR 867
Cdd:pfam08450   15 YWVDILGGRIHR-LDPATGKETVWDTP--GPVGAIAPRDDGGLIVALK--DGVALLDLATGELTPLADPEDDdwplnRFN 89

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207179854  868 DIVVDPIGGFmyWT---DWGANPKIERAGM---DAWNRTVIISSNLTWPNGLAIDYSTERLYWADASVKTI 932
Cdd:pfam08450   90 DGKVDPDGRF--WFgtmGDDEAPGGDPGALyrlDPDGKLTRVLDGLTISNGLAWSPDGRTLYFADSPARKI 158
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 799-916 2.55e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 41.81  E-value: 2.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  799 TDSINRALW----DGSKQEVVVDTSLESPAGLAIDwLTHKLYWTDAGTDRIEVSNTDGSMRTVLIWENLDRPRDIVVDPI 874
Cdd:cd14952     68 TDFGNNRVLklaaGSTTQTVLPFTGLNDPTGVAVD-AAGNVYVADTGNNRVLKLAAGSNTQTVLPFTGLSNPDGVAVDGA 146

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1207179854  875 GGFmYWTDWGANpKIERAGMDAWNRTVIISSNLTWPNGLAID 916
Cdd:cd14952    147 GNV-YVTDTGNN-RVLKLAAGSTTQTVLPFTGLNSPSGVAVD 186
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 777-810 2.67e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 37.20  E-value: 2.67e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1207179854   777 NAVALDWDsldsESFIYWTDVTTDSINRALWDGS 810
Cdd:smart00135   12 NGLAVDWI----EGRLYWTDWGLDVIEVANLDGT 41
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 1404-1496 5.61e-03

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 40.65  E-value: 5.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1404 LYYTDVSLDviRRVNLD-GSDMETVIS-SGLKTTDGLAVDwVARNMYWTDTGRNTIEVAHLDGTSRKVLVNNSLDEPRAI 1481
Cdd:cd14952     23 VYVADSGNN--RVLKLAaGSTTQTVLPfTGLYQPQGVAVD-AAGTVYVTDFGNNRVLKLAAGSTTQTVLPFTGLNDPTGV 99

                           90
                   ....*....|....*
gi 1207179854 1482 AVFPSkGFLFWTDWG 1496
Cdd:cd14952    100 AVDAA-GNVYVADTG 113
EGF smart00181
Epidermal growth factor-like domain;
400-431 5.85e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 36.34  E-value: 5.85e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1207179854   400 ECADDGYCSQG-CTNIEGGFQCWCVQGYELRPD 431
Cdd:smart00181    1 ECASGGPCSNGtCINTPGSYTCSCPPGYTGDKR 33
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 787-967 6.69e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 40.65  E-value: 6.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  787 DSESFIYWTDVTTDSInrALWDGSKQEVVV-----DTSLESPAGLAIDwLTHKLYWTDAGTDRIEVSNTDGS-MRTVLIW 860
Cdd:cd14962     20 DGRGRIYVADTGRGAV--FVFDLPNGKVFVignagPNRFVSPIGVAID-ANGNLYVSDAELGKVFVFDRDGKfLRAIGAG 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  861 ENLDRPRDIVVDPIGGFMYWTDWGA------------------------------NPKIERAG----MDAWNRTVII--- 903
Cdd:cd14962     97 ALFKRPTGIAVDPAGKRLYVVDTLAhkvkvfdldgrllfdigkrgsgpgefnlptDLAVDRDGnlyvTDTMNFRVQIfda 176

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854  904 --------------SSNLTWPNGLAIDySTERLYWADASvktieYGN---FDGSGRQVL-IGSQLPHPFGLTL------- 958
Cdd:cd14962    177 dgkflrsfgergdgPGSFARPKGIAVD-SEGNIYVVDAA-----FDNvqiFNPEGELLLtVGGPGSGPGEFYLpsgiaid 250


                   ....*....
gi 1207179854  959 HEDRIYWTD 967
Cdd:cd14962    251 KDDRIYVVD 259
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 1437-1553 9.70e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 39.88  E-value: 9.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207179854 1437 GLAVDWVARnMYWTDTGRNTIEVAHLDGTSRKVLVN---NSLDEPRAIAVFPsKGFLFWTDwghiAKIERAFLDGTDRKV 1513
Cdd:cd14962     16 GVAADGRGR-IYVADTGRGAVFVFDLPNGKVFVIGNagpNRFVSPIGVAIDA-NGNLYVSD----AELGKVFVFDRDGKF 89

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1207179854 1514 L--INTDLGW--PNGLTLDYDTRRIFWVDAHLDRIESSDLNGKL 1553
Cdd:cd14962     90 LraIGAGALFkrPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRL 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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