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Conserved domains on  [gi|1046892405|ref|XP_017449676|]
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WD repeat-containing protein 20 isoform X3 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
282-388 6.97e-21

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 95.36  E-value: 6.97e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046892405 282 STRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 361
Cdd:COG2319   276 ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVR 355

                          90       100
                  ....*....|....*....|....*..
gi 1046892405 362 VWSFLDCRVIARGHGHKSWVSVVAFDP 388
Cdd:COG2319   356 LWDLATGELLRTLTGHTGAVTSVAFSP 382
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 192-364 1.98e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 68.13  E-value: 1.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046892405 192 DVWCWYITPSDvwreWTVSSSYALQIERLID-------------KSRVTCVKWVPGSESLFLVAhSSGSMYLYNVEhtcg 258
Cdd:cd00200   137 WVNSVAFSPDG----TFVASSSQDGTIKLWDlrtgkcvatltghTGEVNSVAFSPDGEKLLSSS-SDGTIKLWDLS---- 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046892405 259 ttaphyqllkqgESFAVHTCKSKstrnpllkwtvgEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGG 338
Cdd:cd00200   208 ------------TGKCLGTLRGH------------ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNS 263

                         170       180
                  ....*....|....*....|....*.
gi 1046892405 339 LLCVCWSPDGKYIVTGGEDDLVTVWS 364
Cdd:cd00200   264 VTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
282-388 6.97e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 95.36  E-value: 6.97e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046892405 282 STRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 361
Cdd:COG2319   276 ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVR 355

                          90       100
                  ....*....|....*....|....*..
gi 1046892405 362 VWSFLDCRVIARGHGHKSWVSVVAFDP 388
Cdd:COG2319   356 LWDLATGELLRTLTGHTGAVTSVAFSP 382
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 223-388 4.69e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.16  E-value: 4.69e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046892405 223 KSRVTCVKWVPGSEsLFLVAHSSGSMYLYNVEHT------CGTTAP--HYQLLKQGESFAV----HTCKSKSTRNPLLKW 290
Cdd:cd00200     9 TGGVTCVAFSPDGK-LLATGSGDGTIKVWDLETGellrtlKGHTGPvrDVAASADGTYLASgssdKTIRLWDLETGECVR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046892405 291 TVG--EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFLDC 368
Cdd:cd00200    88 TLTghTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG 167

                         170       180
                  ....*....|....*....|
gi 1046892405 369 RVIARGHGHKSWVSVVAFDP 388
Cdd:cd00200   168 KCVATLTGHTGEVNSVAFSP 187
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 192-364 1.98e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.13  E-value: 1.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046892405 192 DVWCWYITPSDvwreWTVSSSYALQIERLID-------------KSRVTCVKWVPGSESLFLVAhSSGSMYLYNVEhtcg 258
Cdd:cd00200   137 WVNSVAFSPDG----TFVASSSQDGTIKLWDlrtgkcvatltghTGEVNSVAFSPDGEKLLSSS-SDGTIKLWDLS---- 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046892405 259 ttaphyqllkqgESFAVHTCKSKstrnpllkwtvgEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGG 338
Cdd:cd00200   208 ------------TGKCLGTLRGH------------ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNS 263

                         170       180
                  ....*....|....*....|....*.
gi 1046892405 339 LLCVCWSPDGKYIVTGGEDDLVTVWS 364
Cdd:cd00200   264 VTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 327-364 4.96e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 4.96e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1046892405  327 ELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWS 364
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
327-364 2.90e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 2.90e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1046892405 327 ELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWS 364
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
282-388 6.97e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 95.36  E-value: 6.97e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046892405 282 STRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 361
Cdd:COG2319   276 ATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVR 355

                          90       100
                  ....*....|....*....|....*..
gi 1046892405 362 VWSFLDCRVIARGHGHKSWVSVVAFDP 388
Cdd:COG2319   356 LWDLATGELLRTLTGHTGAVTSVAFSP 382
WD40 COG2319
WD40 repeat [General function prediction only];
282-388 8.76e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.98  E-value: 8.76e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046892405 282 STRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 361
Cdd:COG2319   108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVR 187

                          90       100
                  ....*....|....*....|....*..
gi 1046892405 362 VWSFLDCRVIARGHGHKSWVSVVAFDP 388
Cdd:COG2319   188 LWDLATGKLLRTLTGHTGAVRSVAFSP 214
WD40 COG2319
WD40 repeat [General function prediction only];
282-388 1.27e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.59  E-value: 1.27e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046892405 282 STRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 361
Cdd:COG2319   234 ATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313

                          90       100
                  ....*....|....*....|....*..
gi 1046892405 362 VWSFLDCRVIARGHGHKSWVSVVAFDP 388
Cdd:COG2319   314 LWDLATGKLLRTLTGHTGAVRSVAFSP 340
WD40 COG2319
WD40 repeat [General function prediction only];
282-388 1.33e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.51  E-value: 1.33e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046892405 282 STRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 361
Cdd:COG2319   150 ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVR 229

                          90       100
                  ....*....|....*....|....*..
gi 1046892405 362 VWSFLDCRVIARGHGHKSWVSVVAFDP 388
Cdd:COG2319   230 LWDLATGKLLRTLTGHSGSVRSVAFSP 256
WD40 COG2319
WD40 repeat [General function prediction only];
283-388 3.46e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.36  E-value: 3.46e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046892405 283 TRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTV 362
Cdd:COG2319   193 TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRL 272

                          90       100
                  ....*....|....*....|....*.
gi 1046892405 363 WSFLDCRVIARGHGHKSWVSVVAFDP 388
Cdd:COG2319   273 WDLATGELLRTLTGHSGGVNSVAFSP 298
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 223-388 4.69e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.16  E-value: 4.69e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046892405 223 KSRVTCVKWVPGSEsLFLVAHSSGSMYLYNVEHT------CGTTAP--HYQLLKQGESFAV----HTCKSKSTRNPLLKW 290
Cdd:cd00200     9 TGGVTCVAFSPDGK-LLATGSGDGTIKVWDLETGellrtlKGHTGPvrDVAASADGTYLASgssdKTIRLWDLETGECVR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046892405 291 TVG--EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFLDC 368
Cdd:cd00200    88 TLTghTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG 167

                         170       180
                  ....*....|....*....|
gi 1046892405 369 RVIARGHGHKSWVSVVAFDP 388
Cdd:cd00200   168 KCVATLTGHTGEVNSVAFSP 187
WD40 COG2319
WD40 repeat [General function prediction only];
283-388 8.01e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.96  E-value: 8.01e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046892405 283 TRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTV 362
Cdd:COG2319    67 AGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL 146

                          90       100
                  ....*....|....*....|....*.
gi 1046892405 363 WSFLDCRVIARGHGHKSWVSVVAFDP 388
Cdd:COG2319   147 WDLATGKLLRTLTGHSGAVTSVAFSP 172
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 294-388 1.94e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 74.29  E-value: 1.94e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046892405 294 EGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFLDCRVIAR 373
Cdd:cd00200   135 TDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT 214

                          90
                  ....*....|....*
gi 1046892405 374 GHGHKSWVSVVAFDP 388
Cdd:cd00200   215 LRGHENGVNSVAFSP 229
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 192-388 2.41e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.83  E-value: 2.41e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046892405 192 DVWCWYITPSD----------VWREWTVSSSYALQIERLIDKSrVTCVKWVPGSESLFlVAHSSGSMYLYNVE-HTCGTT 260
Cdd:cd00200    95 YVSSVAFSPDGrilssssrdkTIKVWDVETGKCLTTLRGHTDW-VNSVAFSPDGTFVA-SSSQDGTIKLWDLRtGKCVAT 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046892405 261 aphyqllkqgesFAVHTckskstrnpllkwtvgeGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLL 340
Cdd:cd00200   173 ------------LTGHT-----------------GEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVN 223

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1046892405 341 CVCWSPDGKYIVTGGEDDLVTVWSFLDCRVIARGHGHKSWVSVVAFDP 388
Cdd:cd00200   224 SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP 271
WD40 COG2319
WD40 repeat [General function prediction only];
282-364 3.42e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.87  E-value: 3.42e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046892405 282 STRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 361
Cdd:COG2319   318 ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVR 397


                  ...
gi 1046892405 362 VWS 364
Cdd:COG2319   398 LWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 192-364 1.98e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.13  E-value: 1.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046892405 192 DVWCWYITPSDvwreWTVSSSYALQIERLID-------------KSRVTCVKWVPGSESLFLVAhSSGSMYLYNVEhtcg 258
Cdd:cd00200   137 WVNSVAFSPDG----TFVASSSQDGTIKLWDlrtgkcvatltghTGEVNSVAFSPDGEKLLSSS-SDGTIKLWDLS---- 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046892405 259 ttaphyqllkqgESFAVHTCKSKstrnpllkwtvgEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGG 338
Cdd:cd00200   208 ------------TGKCLGTLRGH------------ENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNS 263

                         170       180
                  ....*....|....*....|....*.
gi 1046892405 339 LLCVCWSPDGKYIVTGGEDDLVTVWS 364
Cdd:cd00200   264 VTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 328-393 9.30e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.12  E-value: 9.30e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1046892405 328 LHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWSFLDCRVIARGHGHKSWVSVVAFDPYTTSV 393
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYL 66
WD40 COG2319
WD40 repeat [General function prediction only];
282-388 1.27e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.07  E-value: 1.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046892405 282 STRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFNFDSVELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVT 361
Cdd:COG2319    24 ALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVR 103

                          90       100
                  ....*....|....*....|....*..
gi 1046892405 362 VWSFLDCRVIARGHGHKSWVSVVAFDP 388
Cdd:COG2319   104 LWDLATGLLLRTLTGHTGAVRSVAFSP 130
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 327-364 4.96e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 4.96e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1046892405  327 ELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWS 364
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 291-362 5.49e-05

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 43.89  E-value: 5.49e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046892405 291 TVGEGALNEFAFSPDGKFLACVSQ-DGFLRVF--NFDSvelhGTMKSYFGGLLCVCWSPDGKYIV----TGGEDDLVTV 362
Cdd:COG0823    71 TFGGGYNASPSWSPDGKRLAFVSRsDGRFDIYvlDLDG----GAPRRLTDGPGSPSWSPDGRRIVfssdRGGRPDLYVV 145
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 222-363 1.60e-04

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 44.14  E-value: 1.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046892405 222 DKSR-VTCVKWV-PGSESLFLVAHSSGSMYLYNVEhtcgttaphyqllkQGESFAVHTCKSKSTRNPLLKWTVGegaLNE 299
Cdd:cd22857    28 DKSKaVQALSIAdRESEPLLAVARKNGTVEVLDPE--------------NGDLLASFSDSEPATKLSEEDHFVG---LHL 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046892405 300 FafspDGKFLACVSQdGFLRVFNFDSVELHG---TMKSYFGGLLCvCW--SPDGKYIVTGGEDDLVTVW 363
Cdd:cd22857    91 F----SGTLLTCTSK-GSLRSTKLPDDSTASsspTAWVCLGGNLL-CMrvDPNENYFAFGGKEVELNVW 153
WD40 pfam00400
WD domain, G-beta repeat;
327-364 2.90e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 2.90e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1046892405 327 ELHGTMKSYFGGLLCVCWSPDGKYIVTGGEDDLVTVWS 364
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 298-352 4.87e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 43.49  E-value: 4.87e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046892405  298 NEFAFSPDGKFLACVSQDGFLRVFNFDSvelhGTMK-----SYFGGLLCVCWSPDGKYIV 352
Cdd:COG4946    392 FNPVWSPDGKKIAFTDNRGRLWVVDLAS----GKVRkvdtdGYGDGISDLAWSPDSKWLA 447
Nsa1_WDR74-like cd22850
Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 ...
 222-371 2.32e-03

Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi and WDR74 (WD repeat-containing protein 74) from mammals and plants, are homologous essential factors for ribosome assembly. In cooperation with the assembly factor Rix7/NVL2, Nsa1/WDR74 participates in an early cleavage of the pre-rRNA processing pathway. Rix7/NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1/WDR74 from nucleolar pre-60S particles. Nsa1/WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7/NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439302 [Multi-domain]  Cd Length: 333  Bit Score: 40.69  E-value: 2.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046892405 222 DKSRVTCVKWVPGSESLFLVAHSSGSMYLYNVEHTCgttaphyqllkqGESFAVHTCKSKSTRNPLLKWTVGegaLNEFa 301
Cdd:cd22850    33 LSNAVQRLSLVDRSDPLLLVARRNGNGEVYVLSPVD------------GELFELLSSIEGLTRSKEEDKFVG---LHLL- 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046892405 302 fsPDGKFLACVSQDGFLRVFNFDSV---ELHGTMKSYFGGLLCVC--WSPDGKYIVTGGEDDLVTVW----SFLDCRVI 371
Cdd:cd22850    97 --RSLGLLTCATKSGLLHIIDLEDSkkdSLEVKAPLTLPGFLSAFrvNPTDEGVFAYGGKENDLKLWdlekDFLKLKQI 173
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 291-362 2.69e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 38.88  E-value: 2.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046892405 291 TVGEGALNEFAFSPDGKFLACVS-QDGFLRVFnfdSVELHGTMKSY--FGGLLCVC--WSPDGKYIV----TGGEDDLVT 361
Cdd:COG0823    27 TNSPGIDTSPAWSPDGRRIAFTSdRGGGPQIY---VVDADGGEPRRltFGGGYNASpsWSPDGKRLAfvsrSDGRFDIYV 103


                  .
gi 1046892405 362 V 362
Cdd:COG0823   104 L 104
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 283-322 7.22e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.60  E-value: 7.22e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1046892405  283 TRNPLLKWTVGEGALNEFAFSPDGKFLACVSQDGFLRVFN 322
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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