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Conserved domains on  [gi|1046896005|ref|XP_017450363|]
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dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase isoform X1 [Rattus norvegicus]

Protein Classification

glycosyltransferase family protein( domain architecture ID 229536)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PMT_2 super family cl21590
Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are ...
 17-405 9.28e-29

Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are not captured by pfam02366.


The actual alignment was detected with superfamily member pfam03901:

Pssm-ID: 473917  Cd Length: 414  Bit Score: 117.47  E-value: 9.28e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046896005  17 LLVTVAAIHLVACPYT---KVEESFNLQATHDLLYHQLDIDKYDHHEFPGVVPRTFLgplliAAFSSPVVYVLSLLEVSR 93
Cdd:pfam03901   2 IFLLLLALRLLLALLVqtsDPDEHFQSWEPLHYLIFGYGFLTWEWSPKYGIRSYLYP-----LLFALPYYLLARLFGDSK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046896005  94 FYSQLIVRGVLGLGVIFGLWTLQKAVRQQFGATVAVMFCWISATQFHLMFYCTRTLPNVLALAVVLPALTAWL------- 166
Cdd:pfam03901  77 YLVFYAPRLLLGLFSALCDYYLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLeygntsv 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046896005 167 ---QHRWAVFvWLSAFVIIGFRAELAMLLGIMLLLTLYQRRMSVARLLQHAIPAGILCLGLT----VAVDSYFWRYLVWP 239
Cdd:pfam03901 157 snyKYLKAVL-LIAALAILGRPTSALLWLPLVLYLLLRLRGKRLKLFLFLAISLGLLVALLVlgavILIDSYFYGRFVFT 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046896005 240 EGVVLWYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLGAV------DRRTFALALPSLGFVALYSLLPHKELRF 313
Cdd:pfam03901 236 PLNFLKYNVLSNGSSFYGTHPWYFYFSNGLPNILGPFLLAFILGPLvlllrkVSRLSQLLAPILIWLFIYSLQPHKEERF 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046896005 314 IIYTFPVLNIMAARGCT-YVLNKKSWPYKVRALLVFGHVVVNVASTATSLYVSHFNYPGGVAMQRLHELVPPQTDVL--- 389
Cdd:pfam03901 316 LYPVYPLILLSAAIALTrLSRRSWKVRKKLSLLFLLLFFNVSLARLFGLVHQYGAPLAVYDVMSFLNETPRENRNPAgpp 395

                         410
                  ....*....|....*...
gi 1046896005 390 --VHIDVAAAQTGVSRFL 405
Cdd:pfam03901 396 vnVCIGMECYSTPSSFFL 413
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 17-405 9.28e-29

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 117.47  E-value: 9.28e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046896005  17 LLVTVAAIHLVACPYT---KVEESFNLQATHDLLYHQLDIDKYDHHEFPGVVPRTFLgplliAAFSSPVVYVLSLLEVSR 93
Cdd:pfam03901   2 IFLLLLALRLLLALLVqtsDPDEHFQSWEPLHYLIFGYGFLTWEWSPKYGIRSYLYP-----LLFALPYYLLARLFGDSK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046896005  94 FYSQLIVRGVLGLGVIFGLWTLQKAVRQQFGATVAVMFCWISATQFHLMFYCTRTLPNVLALAVVLPALTAWL------- 166
Cdd:pfam03901  77 YLVFYAPRLLLGLFSALCDYYLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLeygntsv 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046896005 167 ---QHRWAVFvWLSAFVIIGFRAELAMLLGIMLLLTLYQRRMSVARLLQHAIPAGILCLGLT----VAVDSYFWRYLVWP 239
Cdd:pfam03901 157 snyKYLKAVL-LIAALAILGRPTSALLWLPLVLYLLLRLRGKRLKLFLFLAISLGLLVALLVlgavILIDSYFYGRFVFT 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046896005 240 EGVVLWYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLGAV------DRRTFALALPSLGFVALYSLLPHKELRF 313
Cdd:pfam03901 236 PLNFLKYNVLSNGSSFYGTHPWYFYFSNGLPNILGPFLLAFILGPLvlllrkVSRLSQLLAPILIWLFIYSLQPHKEERF 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046896005 314 IIYTFPVLNIMAARGCT-YVLNKKSWPYKVRALLVFGHVVVNVASTATSLYVSHFNYPGGVAMQRLHELVPPQTDVL--- 389
Cdd:pfam03901 316 LYPVYPLILLSAAIALTrLSRRSWKVRKKLSLLFLLLFFNVSLARLFGLVHQYGAPLAVYDVMSFLNETPRENRNPAgpp 395

                         410
                  ....*....|....*...
gi 1046896005 390 --VHIDVAAAQTGVSRFL 405
Cdd:pfam03901 396 vnVCIGMECYSTPSSFFL 413
PLN02816 PLN02816
mannosyltransferase
 67-371 3.77e-06

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 49.26  E-value: 3.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046896005  67 RTFLGPLLIAafsspvvYVLSLLEVSRFYSQLIV----RGVLGLGVIFGLWTLQKAVRQQFGATVAVMFCWISATQFHLM 142
Cdd:PLN02816   91 RSYLHPMLFA-------FLYKLLQVTGLDTPYIMikapRLMQSIFSAIGDLYLYKLSDALYGGNVATWSLFCQMANWFIF 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046896005 143 FYCTRTLPNVLALAVVLPALTAW-----------LQHRWAVFVwlsAFVIIGFRAELAMLLGIMLLLTLYQRRMSVARLL 211
Cdd:PLN02816  164 FCLNRTFSNCLETVLTIMGLYYWpcirdssidypVNRKWGLVI---AALACAIRPTSAVIWLYVGMLELFLTPNKVKFII 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046896005 212 QHAIPAGILCLGLTVAVDSYFWRYLVWPEGVVLWYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLGAVDRRTFA 291
Cdd:PLN02816  241 LEVIPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFNFLSSGGDYYGTHPWHWYFTQGFLVMLFTFTPFSIAGIIKSKNQK 320

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046896005 292 LALPSLGFVALYSLLPHKELRFII-----------YTFPVLNIMAARGCTYVLNKKS--------WPYKVRaLLVFGHVV 352
Cdd:PLN02816  321 LSALILWVLAIYSILGHKEFRFVLpvlpialifsgYAFAQMEVSGSSSSSSVTKKKQvprqnhtkWSPKLR-LSVYFLLA 399

                         330
                  ....*....|....*....
gi 1046896005 353 VNVastATSLYVSHFNYPG 371
Cdd:PLN02816  400 TNI---PMALYMSLFHQRG 415
 
Name Accession Description Interval E-value
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 17-405 9.28e-29

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 117.47  E-value: 9.28e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046896005  17 LLVTVAAIHLVACPYT---KVEESFNLQATHDLLYHQLDIDKYDHHEFPGVVPRTFLgplliAAFSSPVVYVLSLLEVSR 93
Cdd:pfam03901   2 IFLLLLALRLLLALLVqtsDPDEHFQSWEPLHYLIFGYGFLTWEWSPKYGIRSYLYP-----LLFALPYYLLARLFGDSK 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046896005  94 FYSQLIVRGVLGLGVIFGLWTLQKAVRQQFGATVAVMFCWISATQFHLMFYCTRTLPNVLALAVVLPALTAWL------- 166
Cdd:pfam03901  77 YLVFYAPRLLLGLFSALCDYYLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLeygntsv 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046896005 167 ---QHRWAVFvWLSAFVIIGFRAELAMLLGIMLLLTLYQRRMSVARLLQHAIPAGILCLGLT----VAVDSYFWRYLVWP 239
Cdd:pfam03901 157 snyKYLKAVL-LIAALAILGRPTSALLWLPLVLYLLLRLRGKRLKLFLFLAISLGLLVALLVlgavILIDSYFYGRFVFT 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046896005 240 EGVVLWYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLGAV------DRRTFALALPSLGFVALYSLLPHKELRF 313
Cdd:pfam03901 236 PLNFLKYNVLSNGSSFYGTHPWYFYFSNGLPNILGPFLLAFILGPLvlllrkVSRLSQLLAPILIWLFIYSLQPHKEERF 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046896005 314 IIYTFPVLNIMAARGCT-YVLNKKSWPYKVRALLVFGHVVVNVASTATSLYVSHFNYPGGVAMQRLHELVPPQTDVL--- 389
Cdd:pfam03901 316 LYPVYPLILLSAAIALTrLSRRSWKVRKKLSLLFLLLFFNVSLARLFGLVHQYGAPLAVYDVMSFLNETPRENRNPAgpp 395

                         410
                  ....*....|....*...
gi 1046896005 390 --VHIDVAAAQTGVSRFL 405
Cdd:pfam03901 396 vnVCIGMECYSTPSSFFL 413
PLN02816 PLN02816
mannosyltransferase
 67-371 3.77e-06

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 49.26  E-value: 3.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046896005  67 RTFLGPLLIAafsspvvYVLSLLEVSRFYSQLIV----RGVLGLGVIFGLWTLQKAVRQQFGATVAVMFCWISATQFHLM 142
Cdd:PLN02816   91 RSYLHPMLFA-------FLYKLLQVTGLDTPYIMikapRLMQSIFSAIGDLYLYKLSDALYGGNVATWSLFCQMANWFIF 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046896005 143 FYCTRTLPNVLALAVVLPALTAW-----------LQHRWAVFVwlsAFVIIGFRAELAMLLGIMLLLTLYQRRMSVARLL 211
Cdd:PLN02816  164 FCLNRTFSNCLETVLTIMGLYYWpcirdssidypVNRKWGLVI---AALACAIRPTSAVIWLYVGMLELFLTPNKVKFII 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046896005 212 QHAIPAGILCLGLTVAVDSYFWRYLVWPEGVVLWYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLGAVDRRTFA 291
Cdd:PLN02816  241 LEVIPIGSLVLGFTCLLDRLMYGSWVIVPLNFLKFNFLSSGGDYYGTHPWHWYFTQGFLVMLFTFTPFSIAGIIKSKNQK 320

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046896005 292 LALPSLGFVALYSLLPHKELRFII-----------YTFPVLNIMAARGCTYVLNKKS--------WPYKVRaLLVFGHVV 352
Cdd:PLN02816  321 LSALILWVLAIYSILGHKEFRFVLpvlpialifsgYAFAQMEVSGSSSSSSVTKKKQvprqnhtkWSPKLR-LSVYFLLA 399

                         330
                  ....*....|....*....
gi 1046896005 353 VNVastATSLYVSHFNYPG 371
Cdd:PLN02816  400 TNI---PMALYMSLFHQRG 415
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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