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Conserved domains on  [gi|1046899980|ref|XP_017451087|]
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leucine-rich repeat-containing protein 2 isoform X1 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
113-360 2.96e-36

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 136.60  E-value: 2.96e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 113 LSGTQWKELPDSLKEQTHLKEWHIHNTLIQIIPTYIELFHSMKILDLPKNQITCLPPEIGRLKNLKELNVSFNHLKSIPP 192
Cdd:COG4886   120 LSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 193 ELGDCENLERLDCSGNlDLMELPFELSNLKQVTFVDISANKFSSVPiCVLRMCRLQWLDISSNDLTDLPqDIDRLEELQG 272
Cdd:COG4886   200 PLGNLTNLEELDLSGN-QLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKT 276

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 273 FLLYKNKLTYlpqamLNLKKLTLLVVSGDDLVELPTALCDASTPLKFVSLLDNPIDKTRCQDTDDTVESEQDRQHFDKEF 352
Cdd:COG4886   277 LDLSNNQLTD-----LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351


                  ....*...
gi 1046899980 353 MKAYIEDL 360
Cdd:COG4886   352 LLLLLNLL 359
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
113-360 2.96e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 136.60  E-value: 2.96e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 113 LSGTQWKELPDSLKEQTHLKEWHIHNTLIQIIPTYIELFHSMKILDLPKNQITCLPPEIGRLKNLKELNVSFNHLKSIPP 192
Cdd:COG4886   120 LSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 193 ELGDCENLERLDCSGNlDLMELPFELSNLKQVTFVDISANKFSSVPiCVLRMCRLQWLDISSNDLTDLPqDIDRLEELQG 272
Cdd:COG4886   200 PLGNLTNLEELDLSGN-QLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKT 276

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 273 FLLYKNKLTYlpqamLNLKKLTLLVVSGDDLVELPTALCDASTPLKFVSLLDNPIDKTRCQDTDDTVESEQDRQHFDKEF 352
Cdd:COG4886   277 LDLSNNQLTD-----LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351


                  ....*...
gi 1046899980 353 MKAYIEDL 360
Cdd:COG4886   352 LLLLLNLL 359
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 138-328 2.08e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 77.97  E-value: 2.08e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 138 NTLIQIIPTYIELFHSMKILDLPKNQITC-LPPEIGRLKNLKELNVSFNHLK-SIPPELGDCENLERLDCSGNLDLMELP 215
Cdd:PLN00113  174 NVLVGKIPNSLTNLTSLEFLTLASNQLVGqIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLTGPIP 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 216 FELSNLKQVTFVDISANKFS-SVPICVLRMCRLQWLDISSNDLT-DLPQDIDRLEELQGFLLYKNKLT-YLPQAMLNLKK 292
Cdd:PLN00113  254 SSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPR 333

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1046899980 293 L------------------------TLLVVSGDDLV-ELPTALCDASTPLKFVsLLDNPID 328
Cdd:PLN00113  334 LqvlqlwsnkfsgeipknlgkhnnlTVLDLSTNNLTgEIPEGLCSSGNLFKLI-LFSNSLE 393
LRR_8 pfam13855
Leucine rich repeat;
153-209 2.83e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 2.83e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1046899980 153 SMKILDLPKNQITCLPPEI-GRLKNLKELNVSFNHLKSIPPE-LGDCENLERLDCSGNL 209
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNR 60
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 125-208 1.82e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.47  E-value: 1.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 125 LKEQTHLKEWHIHNtliQIIP----------TYIELFHSMKILDLPKNQITCLPPeIGRLKNLKELNVSFNHLKSIP--- 191
Cdd:cd21340    86 LENLTNLEELHIEN---QRLPpgekltfdprSLAALSNSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISDLEell 161

                          90
                  ....*....|....*..
gi 1046899980 192 PELGDCENLERLDCSGN 208
Cdd:cd21340   162 DLLSSWPSLRELDLTGN 178
LRR smart00370
Leucine-rich repeats, outliers;
174-197 9.06e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 33.48  E-value: 9.06e-03
                           10        20
                   ....*....|....*....|....
gi 1046899980  174 LKNLKELNVSFNHLKSIPPELGDC 197
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
113-360 2.96e-36

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 136.60  E-value: 2.96e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 113 LSGTQWKELPDSLKEQTHLKEWHIHNTLIQIIPTYIELFHSMKILDLPKNQITCLPPEIGRLKNLKELNVSFNHLKSIPP 192
Cdd:COG4886   120 LSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 193 ELGDCENLERLDCSGNlDLMELPFELSNLKQVTFVDISANKFSSVPiCVLRMCRLQWLDISSNDLTDLPqDIDRLEELQG 272
Cdd:COG4886   200 PLGNLTNLEELDLSGN-QLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKT 276

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 273 FLLYKNKLTYlpqamLNLKKLTLLVVSGDDLVELPTALCDASTPLKFVSLLDNPIDKTRCQDTDDTVESEQDRQHFDKEF 352
Cdd:COG4886   277 LDLSNNQLTD-----LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351


                  ....*...
gi 1046899980 353 MKAYIEDL 360
Cdd:COG4886   352 LLLLLNLL 359
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
122-327 2.18e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 134.29  E-value: 2.18e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 122 PDSLKEQTHLKEWHIHNTLIQIIPTYIELFHSMKILDLPKNQITCLPPEIGRLKNLKELNVSFNHLKSIPPELGDCENLE 201
Cdd:COG4886   106 NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLK 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 202 RLDCSGNlDLMELPFELSNLKQVTFVDISANKFSSVPICVLRMCRLQWLDISSNDLTDLPqDIDRLEELQGFLLYKNKLT 281
Cdd:COG4886   186 ELDLSNN-QITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLT 263

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1046899980 282 YLPQAmLNLKKLTLLVVSGDDLVELPTALCDASTPLKFVSLLDNPI 327
Cdd:COG4886   264 DLPPL-ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
112-328 3.14e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 94.23  E-value: 3.14e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 112 ELSGTQWKELPDSLKEQTHLKEWHIHNTLIQIIPTYIELFHSMKILDLPKNQITCLPPEIGRLKNLKELNVSFNHLKSIp 191
Cdd:COG4886   165 DLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL- 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 192 PELGDCENLERLDCSGNlDLMELPfELSNLKQVTFVDISANKFSSVPICVLrmcrlqWLDISSNDLTDLPQDIDRLEELQ 271
Cdd:COG4886   244 PELGNLTNLEELDLSNN-QLTDLP-PLANLTNLKTLDLSNNQLTDLKLKEL------ELLLGLNSLLLLLLLLNLLELLI 315

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1046899980 272 GFLLYKNKLTYLPQAMLNLKKLTLLVVSGDDLVELPTALCDASTPLKFVSLLDNPID 328
Cdd:COG4886   316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLL 372
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
138-327 8.42e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 8.42e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 138 NTLIQIIPTYIELFHSMKILDLPKNQITCLPPEIGRLKNLKELNVSFNHLKSIPPELGDCENLERLDCSGNLdlmelpfE 217
Cdd:COG4886    36 ALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------E 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 218 LSNLKQVTFVDISANKFSSVPICVLRMCRLQWLDISSNDLTDLPQDIDRLEELQGFLLYKNKLTYLPQAMLNLKKLTLLV 297
Cdd:COG4886   109 LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELD 188

                         170       180       190
                  ....*....|....*....|....*....|
gi 1046899980 298 VSGDDLVELPTALCDASTpLKFVSLLDNPI 327
Cdd:COG4886   189 LSNNQITDLPEPLGNLTN-LEELDLSGNQL 217
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 138-328 2.08e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 77.97  E-value: 2.08e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 138 NTLIQIIPTYIELFHSMKILDLPKNQITC-LPPEIGRLKNLKELNVSFNHLK-SIPPELGDCENLERLDCSGNLDLMELP 215
Cdd:PLN00113  174 NVLVGKIPNSLTNLTSLEFLTLASNQLVGqIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNNLTGPIP 253

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 216 FELSNLKQVTFVDISANKFS-SVPICVLRMCRLQWLDISSNDLT-DLPQDIDRLEELQGFLLYKNKLT-YLPQAMLNLKK 292
Cdd:PLN00113  254 SSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPR 333

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1046899980 293 L------------------------TLLVVSGDDLV-ELPTALCDASTPLKFVsLLDNPID 328
Cdd:PLN00113  334 LqvlqlwsnkfsgeipknlgkhnnlTVLDLSTNNLTgEIPEGLCSSGNLFKLI-LFSNSLE 393
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
144-327 4.14e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 67.80  E-value: 4.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 144 IPTYIELFHSMKILDlpKNQITCLPPEIGrlKNLKELNVSFNHLKSIPPELGDceNLERLDCSGNlDLMELPFELSNLKQ 223
Cdd:PRK15370  193 IPACIPEQITTLILD--NNELKSLPENLQ--GNIKTLYANSNQLTSIPATLPD--TIQEMELSIN-RITELPERLPSALQ 265

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 224 VtfVDISANKFSSVPICVLRmcRLQWLDISSNDLTDLPQDIDrlEELQGFLLYKNKLTYLPQAM-LNLKKLtllvVSGDD 302
Cdd:PRK15370  266 S--LDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPETLpPGLKTL----EAGEN 335

                         170       180
                  ....*....|....*....|....*.
gi 1046899980 303 -LVELPTALCDAstpLKFVSLLDNPI 327
Cdd:PRK15370  336 aLTSLPASLPPE---LQVLDVSKNQI 358
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 113-322 3.25e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.87  E-value: 3.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 113 LSGtqwkELPDSLKEQTHLKEWHI-HNTLIQIIPTYIELFHSMKILDLPKNQITC-LPPEIGRLKNLKELNVSFNHLK-- 188
Cdd:PLN00113  296 LSG----EIPELVIQLQNLEILHLfSNNFTGKIPVALTSLPRLQVLQLWSNKFSGeIPKNLGKHNNLTVLDLSTNNLTge 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 189 -----------------------SIPPELGDCENLERLDCSGNLDLMELPFELSNLKQVTFVDISANKFS-SVPICVLRM 244
Cdd:PLN00113  372 ipeglcssgnlfklilfsnslegEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWDM 451

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 245 CRLQWLDISSNDLT-DLPQDI--DRLEELQgflLYKNKLT-YLPQAMLNLKKLTLLVVSGDDLV-ELPTALcdaSTPLKF 319
Cdd:PLN00113  452 PSLQMLSLARNKFFgGLPDSFgsKRLENLD---LSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDEL---SSCKKL 525


                  ...
gi 1046899980 320 VSL 322
Cdd:PLN00113  526 VSL 528
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 138-307 1.31e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.94  E-value: 1.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 138 NTLIQIIPTYI-ELFHSMKILDLPKNQITCLPPEiGRLKNLKELNVSFNHLK-SIPPELGDCENLERLDCSGNLDLMELP 215
Cdd:PLN00113  103 NQLSGPIPDDIfTTSSSLRYLNLSNNNFTGSIPR-GSIPNLETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVGKIP 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 216 FELSNLKQVTFVDISANKFS-SVPICVLRMCRLQW------------------------LDISSNDLT-DLPQDIDRLEE 269
Cdd:PLN00113  182 NSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWiylgynnlsgeipyeiggltslnhLDLVYNNLTgPIPSSLGNLKN 261

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1046899980 270 LQGFLLYKNKLT-YLPQAMLNLKKLTLLVVSGDDLV-ELP 307
Cdd:PLN00113  262 LQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIP 301
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
162-305 1.39e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 53.63  E-value: 1.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 162 NQITCLPPeigRLKNLKELNVSFNHLKSIPPELGDCENLerldCSGNLDLMELPFELSNLKQVTfvdISANKFSSVPICV 241
Cdd:PRK15387  332 NQLTSLPT---LPSGLQELSVSDNQLASLPTLPSELYKL----WAYNNRLTSLPALPSGLKELI---VSGNRLTSLPVLP 401

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1046899980 242 lrmCRLQWLDISSNDLTDLPQDIDRLEELQgflLYKNKLTYLPQAMLNLKKLTLLVVSGDDLVE 305
Cdd:PRK15387  402 ---SELKELMVSGNRLTSLPMLPSGLLSLS---VYRNQLTRLPESLIHLSSETTVNLEGNPLSE 459
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
110-287 6.74e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.24  E-value: 6.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 110 VFELSGTQWKELPDSLKeqTHLKEWHIHNTLIQIIPTyiELFHSMKILDLPKNQITCLPPEIGrlKNLKELNVSFNHLKS 189
Cdd:PRK15370  245 EMELSINRITELPERLP--SALQSLDLFHNKISCLPE--NLPEELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTA 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 190 IPPELGdcENLERLDCSGNLdLMELPFELSNLKQVtfVDISANKFSSVPICVLRMcrLQWLDISSNDLTDLPQDIDrlEE 269
Cdd:PRK15370  319 LPETLP--PGLKTLEAGENA-LTSLPASLPPELQV--LDVSKNQITVLPETLPPT--ITTLDVSRNALTNLPENLP--AA 389

                         170
                  ....*....|....*...
gi 1046899980 270 LQGFLLYKNKLTYLPQAM 287
Cdd:PRK15370  390 LQIMQASRNNLVRLPESL 407
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 154-257 1.89e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.85  E-value: 1.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 154 MKILDLPKNQIT-CLPPEIGRLKNLKELNVSFNHLKS-IPPELGDCENLERLDCSGNLDLMELPFELSNLKQVTFVDISA 231
Cdd:PLN00113  477 LENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQ 556

                          90       100
                  ....*....|....*....|....*..
gi 1046899980 232 NKFS-SVPICVLRMCRLQWLDISSNDL 257
Cdd:PLN00113  557 NQLSgEIPKNLGNVESLVQVNISHNHL 583
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 113-280 7.57e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.92  E-value: 7.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 113 LSGtqwkELPDSLKEQTHLKEWH-IHNTLIQIIPTYIELFHSMKILDLPKNQIT-CLPPEIGRLKNLKELNVSFNHLKSI 190
Cdd:PLN00113  224 LSG----EIPYEIGGLTSLNHLDlVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSGE 299

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 191 PPEL-GDCENLERLDCSGNLDLMELPFELSNLKQVTFVDISANKFS-SVPICVLRMCRLQWLDISSNDLT-DLPQDIDRL 267
Cdd:PLN00113  300 IPELvIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSS 379

                         170
                  ....*....|...
gi 1046899980 268 EELQGFLLYKNKL 280
Cdd:PLN00113  380 GNLFKLILFSNSL 392
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
139-307 1.11e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 47.46  E-value: 1.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 139 TLIQIIPTYIelfhsmKILDLPKNQIT---CLPPEigrlknLKELNVSFNHLKSIPP------ELGDCEN---------- 199
Cdd:PRK15387  215 TLPDCLPAHI------TTLVIPDNNLTslpALPPE------LRTLEVSGNQLTSLPVlppgllELSIFSNplthlpalps 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 200 -LERLDCSGNlDLMELPFELSNLKQVTfvdISANKFSSVPICVLRMCR-----------------LQWLDISSNDLTDLP 261
Cdd:PRK15387  283 gLCKLWIFGN-QLTSLPVLPPGLQELS---VSDNQLASLPALPSELCKlwaynnqltslptlpsgLQELSVSDNQLASLP 358

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1046899980 262 QdidRLEELQGFLLYKNKLTYLPQAMLNLKKltlLVVSGDDLVELP 307
Cdd:PRK15387  359 T---LPSELYKLWAYNNRLTSLPALPSGLKE---LIVSGNRLTSLP 398
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 120-238 2.50e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.38  E-value: 2.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 120 ELPDSLKEQtHLKEWHI-HNTLIQIIPTYIELFHSMKILDLPKNQIT-CLPPEIGRLKNLKELNVSFNHLK-SIPPELGD 196
Cdd:PLN00113  467 GLPDSFGSK-RLENLDLsRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSE 545

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1046899980 197 CENLERLDCSGNLDLMELPFELSNLKQVTFVDISANKF-SSVP 238
Cdd:PLN00113  546 MPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLhGSLP 588
LRR_8 pfam13855
Leucine rich repeat;
153-209 2.83e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 2.83e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1046899980 153 SMKILDLPKNQITCLPPEI-GRLKNLKELNVSFNHLKSIPPE-LGDCENLERLDCSGNL 209
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
246-303 8.76e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 8.76e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 246 RLQWLDISSNDLTDLPQDI-DRLEELQGFLLYKNKLTYL-PQAMLNLKKLTLLVVSGDDL 303
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 175-216 1.04e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.15  E-value: 1.04e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1046899980 175 KNLKELNVSFNHLKSIPPeLGDCENLERLDCSGNLDLMELPF 216
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP-LAKLPNLETLDLSGNNKITDLSD 41
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 125-208 1.82e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.47  E-value: 1.82e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 125 LKEQTHLKEWHIHNtliQIIP----------TYIELFHSMKILDLPKNQITCLPPeIGRLKNLKELNVSFNHLKSIP--- 191
Cdd:cd21340    86 LENLTNLEELHIEN---QRLPpgekltfdprSLAALSNSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISDLEell 161

                          90
                  ....*....|....*..
gi 1046899980 192 PELGDCENLERLDCSGN 208
Cdd:cd21340   162 DLLSSWPSLRELDLTGN 178
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 125-295 2.51e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.08  E-value: 2.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 125 LKEQTHLkewHIHNTLIQIIPTyIELFHSMKILDLPKNQITCLPPeIGRLKNLKELNVSFNHLKSIPPeLGDCENLERLD 204
Cdd:cd21340     1 LKRITHL---YLNDKNITKIDN-LSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLY 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 205 CSGN-------LD----LMEL----------------PFELSNL-KQVTFVDISANKFSSV-PICVLRmcRLQWLDISSN 255
Cdd:cd21340    75 LGGNrisvvegLEnltnLEELhienqrlppgekltfdPRSLAALsNSLRVLNISGNNIDSLePLAPLR--NLEQLDASNN 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1046899980 256 DLTDlpqdidrLEELQGFLlyknkltylpQAMLNLKKLTL 295
Cdd:cd21340   153 QISD-------LEELLDLL----------SSWPSLRELDL 175
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 112-254 7.40e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 7.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046899980 112 ELSGtqwkELPDSLKEQTHLKEWHI-HNTLIQIIPTYIELFHSMKILDLPKNQITC-LPPEIGRLKNLKELNVSFNHLKS 189
Cdd:PLN00113  510 KLSG----EIPDELSSCKKLVSLDLsHNQLSGQIPASFSEMPVLSQLDLSQNQLSGeIPKNLGNVESLVQVNISHNHLHG 585

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1046899980 190 IPPELGDCENLERLDCSGNLDLmelpfelsnlkqvtfvdISANKFSSVPIC-VLRMCRLQWLDISS 254
Cdd:PLN00113  586 SLPSTGAFLAINASAVAGNIDL-----------------CGGDTTSGLPPCkRVRKTPSWWFYITC 634
LRR_8 pfam13855
Leucine rich repeat;
129-187 2.32e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 2.32e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1046899980 129 THLKEWHIHNTLIQIIPTyiELFHSM---KILDLPKNQITCLPPE-IGRLKNLKELNVSFNHL 187
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDD--GAFKGLsnlKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
LRR smart00370
Leucine-rich repeats, outliers;
174-197 9.06e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 33.48  E-value: 9.06e-03
                           10        20
                   ....*....|....*....|....
gi 1046899980  174 LKNLKELNVSFNHLKSIPPELGDC 197
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
174-197 9.06e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 33.48  E-value: 9.06e-03
                           10        20
                   ....*....|....*....|....
gi 1046899980  174 LKNLKELNVSFNHLKSIPPELGDC 197
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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