NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1191843223|ref|XP_020931308|]
View 

sp110 nuclear body protein isoform X4 [Sus scrofa]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HSR pfam03172
HSR domain; The Sp100 protein is a constituent of nuclear domains, also known as nuclear dots ...
 15-113 1.31e-59

HSR domain; The Sp100 protein is a constituent of nuclear domains, also known as nuclear dots (NDs). An ND-targeting region that coincides with a homodimerization domain was mapped in Sp100. Sequences similar to the Sp100 homodimerization/ND-targeting region occur in several other proteins and constitute a novel protein motif, termed HSR domain (for homogeneously-staining region). The HSR domain has also been named ASS (AIRE, Sp-100 and Sp140). This domain is usually found at the amino terminus of proteins that contain a SAND domain pfam01342.


:

Pssm-ID: 460835  Cd Length: 99  Bit Score: 193.91  E-value: 1.31e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  15 LEEALFQHFIHQKLEIAYAINKPFPFFEGLRDNNFITDTLYRESLEACRNLVPVSRVVYNILTKLEKTFSLSFLEMLFGH 94
Cdd:pfam03172   1 LEEALFQHFKENKVEIAYAIKKPFPFLEGLRDHSFITEKMYKESLEACRNLVPVQRVVYNVLSELEKTFSLSLLEALFSD 80

                          90
                  ....*....|....*....
gi 1191843223  95 INLYEYPSLMAVFKSFKNV 113
Cdd:pfam03172  81 VNLKEYPDLIEILKSFPNV 99
Bromodomain super family cl02556
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 523-621 2.53e-45

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


The actual alignment was detected with superfamily member cd05501:

Pssm-ID: 445827  Cd Length: 102  Bit Score: 156.05  E-value: 2.53e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 523 PEEQLKCEFLLLKAYCHPQSSFFAETPRNIQDYGEPFKEAMWLDLVKERLTERVY-TVAWFLRDMRLIFRNHQMFYKASD 601
Cdd:cd05501     1 PEELLKCEFLLLKVYCMSKSGFFISKPYYIRDYCQGIKEPMWLNKVKERLNERVYhTVEGFVRDMRLIFHNHKLFYKDDD 80

                          90       100
                  ....*....|....*....|
gi 1191843223 602 FGQIGLDLEAEFEKDLKKMF 621
Cdd:cd05501    81 FGQVGITLEKKFEKNFKEVF 100
SAND pfam01342
SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The ...
 365-441 2.96e-36

SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The conserved KDWK motif is necessary for DNA binding, and it appears to be important for dimerization. This region is also found in the putative transcription factor RegA from the multicellular green alga Volvox cateri. This region of RegA is known as the VARL domain.


:

Pssm-ID: 460167  Cd Length: 76  Bit Score: 130.01  E-value: 2.96e-36
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1191843223 365 DFHSLILPVTCGEAKGILYKEKMKLGSSEKCIQNEeGVWFTPREFEIEGKQKHKKYWKRSVLCGGKTLEHLIKKGLL 441
Cdd:pfam01342   1 DFDSPVLPVTCGAAKGLLHKKKFKQGISGKCIQNE-DSWLTPKEFEIEGGKASSKDWKRSIRCGGKPLRELIEKGLL 76
PHD_SF super family cl22851
PHD finger superfamily; The PHD finger superfamily includes a canonical plant homeodomain (PHD) ...
 458-499 2.62e-11

PHD finger superfamily; The PHD finger superfamily includes a canonical plant homeodomain (PHD) finger typically characterized as Cys4HisCys3, and a non-canonical extended PHD finger, characterized as Cys2HisCys5HisCys2His. Variations include the RAG2 PHD finger characterized by Cys3His2Cys2His and the PHD finger 5 found in nuclear receptor-binding SET domain-containing proteins characterized by Cys4HisCys2His. The PHD finger is also termed LAP (leukemia-associated protein) motif or TTC (trithorax consensus) domain. Single or multiple copies of PHD fingers have been found in a variety of eukaryotic proteins involved in the control of gene transcription and chromatin dynamics. PHD fingers can recognize the unmodified and modified histone H3 tail, and some have been found to interact with non-histone proteins. They also function as epigenome readers controlling gene expression through molecular recruitment of multi-protein complexes of chromatin regulators and transcription factors. The PHD finger domain SF is structurally similar to the RING and FYVE_like superfamilies.


The actual alignment was detected with superfamily member cd15626:

Pssm-ID: 473978  Cd Length: 42  Bit Score: 58.59  E-value: 2.62e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1191843223 458 ECEVCCGGGLLLCCDTCPRAFHENCHIPPAVAKRRPWSCTFC 499
Cdd:cd15626     1 KCEVCGQEGKLFCCCTCSRVFHEDCHIPPVEAQRSPWSCTFC 42
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 130-363 7.76e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 7.76e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  130 APASTAERSSVRPLLPLPACQGPPPSGPSLVPSVSEPAAPVQPSTEilPKPPSPAGLAKTPPGIIQEGRLTPVSSDSLIL 209
Cdd:PHA03247  2721 LPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGP--PAPAPPAAPAAGPPRRLTRPAVASLSESRESL 2798

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  210 QTEDKEDTPEVPCTPSGSA--PAIKDDSPKPHDPEELQEAPRMPPNKKGKKKKRCIWATP----KRRHKKKCLPREGALP 283
Cdd:PHA03247  2799 PSPWDPADPPAAVLAPAAAlpPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAP 2878

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  284 DHGIQEKLQ--GVDQETQRKddstgnaevmtTAPKTKPKCARTLKPEETTDDIPEVVEEKRPQEPPSRPTRTANKEKPKD 361
Cdd:PHA03247  2879 ARPPVRRLArpAVSRSTESF-----------ALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTT 2947


                   ..
gi 1191843223  362 KT 363
Cdd:PHA03247  2948 DP 2949
 
Name Accession Description Interval E-value
HSR pfam03172
HSR domain; The Sp100 protein is a constituent of nuclear domains, also known as nuclear dots ...
 15-113 1.31e-59

HSR domain; The Sp100 protein is a constituent of nuclear domains, also known as nuclear dots (NDs). An ND-targeting region that coincides with a homodimerization domain was mapped in Sp100. Sequences similar to the Sp100 homodimerization/ND-targeting region occur in several other proteins and constitute a novel protein motif, termed HSR domain (for homogeneously-staining region). The HSR domain has also been named ASS (AIRE, Sp-100 and Sp140). This domain is usually found at the amino terminus of proteins that contain a SAND domain pfam01342.


Pssm-ID: 460835  Cd Length: 99  Bit Score: 193.91  E-value: 1.31e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  15 LEEALFQHFIHQKLEIAYAINKPFPFFEGLRDNNFITDTLYRESLEACRNLVPVSRVVYNILTKLEKTFSLSFLEMLFGH 94
Cdd:pfam03172   1 LEEALFQHFKENKVEIAYAIKKPFPFLEGLRDHSFITEKMYKESLEACRNLVPVQRVVYNVLSELEKTFSLSLLEALFSD 80

                          90
                  ....*....|....*....
gi 1191843223  95 INLYEYPSLMAVFKSFKNV 113
Cdd:pfam03172  81 VNLKEYPDLIEILKSFPNV 99
Bromo_SP100C_like cd05501
Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major ...
 523-621 2.53e-45

Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin level. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99933  Cd Length: 102  Bit Score: 156.05  E-value: 2.53e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 523 PEEQLKCEFLLLKAYCHPQSSFFAETPRNIQDYGEPFKEAMWLDLVKERLTERVY-TVAWFLRDMRLIFRNHQMFYKASD 601
Cdd:cd05501     1 PEELLKCEFLLLKVYCMSKSGFFISKPYYIRDYCQGIKEPMWLNKVKERLNERVYhTVEGFVRDMRLIFHNHKLFYKDDD 80

                          90       100
                  ....*....|....*....|
gi 1191843223 602 FGQIGLDLEAEFEKDLKKMF 621
Cdd:cd05501    81 FGQVGITLEKKFEKNFKEVF 100
SAND pfam01342
SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The ...
 365-441 2.96e-36

SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The conserved KDWK motif is necessary for DNA binding, and it appears to be important for dimerization. This region is also found in the putative transcription factor RegA from the multicellular green alga Volvox cateri. This region of RegA is known as the VARL domain.


Pssm-ID: 460167  Cd Length: 76  Bit Score: 130.01  E-value: 2.96e-36
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1191843223 365 DFHSLILPVTCGEAKGILYKEKMKLGSSEKCIQNEeGVWFTPREFEIEGKQKHKKYWKRSVLCGGKTLEHLIKKGLL 441
Cdd:pfam01342   1 DFDSPVLPVTCGAAKGLLHKKKFKQGISGKCIQNE-DSWLTPKEFEIEGGKASSKDWKRSIRCGGKPLRELIEKGLL 76
SAND smart00258
SAND domain;
370-441 1.02e-23

SAND domain;


Pssm-ID: 128554  Cd Length: 73  Bit Score: 94.72  E-value: 1.02e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1191843223  370 ILPVTCGEAKGILYKEKMKLGSSEKCIQNEEGvWFTPREFEIEGKQKHKKYWKRSVLCGGKTLEHLIKKGLL 441
Cdd:smart00258   2 ELPVTCGTVKGILYKKKFKCGISVKCIQYEDK-WFTPKEFEIEGGKGKSKDWKRSIRCGGSSLRTLMENGTL 72
BROMO smart00297
bromo domain;
523-620 2.79e-13

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 66.15  E-value: 2.79e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  523 PEEQLKCEFLLLKAYC----HPQSSFFAE--TPRNIQDYGEPFKEAMWLDLVKERLTERVYTVAW-FLRDMRLIFRNHQM 595
Cdd:smart00297   2 PKLQKKLQELLKAVLDkldsHPLSWPFLKpvSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEeFVADFNLMFSNART 81

                           90       100
                   ....*....|....*....|....*.
gi 1191843223  596 FY-KASDFGQIGLDLEAEFEKDLKKM 620
Cdd:smart00297  82 YNgPDSEVYKDAKKLEKFFEKKLREL 107
PHD_SP110_140 cd15626
PHD finger found in the Sp100/Sp140 family of nuclear body components; The Sp100/Sp140 family ...
 458-499 2.62e-11

PHD finger found in the Sp100/Sp140 family of nuclear body components; The Sp100/Sp140 family includes nuclear body proteins SP100, SP140, and similar proteins. Sp110, also termed interferon-induced protein 41/75, or speckled 110 kDa, or transcriptional coactivator Sp110, is a leukocyte-specific component of the nuclear body. It may function as a nuclear hormone receptor transcriptional coactivator that may play a role in inducing differentiation of myeloid cells. It is also involved in resisting intracellular pathogens and functions as an important drug target for preventing intracellular pathogen diseases, such as tuberculosis, hepatic veno-occlusive disease, and intracellular cancers. Sp110 gene polymorphisms may be associated with susceptibility to tuberculosis in Chinese population. Sp110 contains a Sp100-like domain, a SAND domain, a plant homeodomain (PHD) finger, and a bromodomain (BRD). SP140, also termed lymphoid-restricted homolog of Sp100 (LYSp100), or nuclear autoantigen Sp-140, or speckled 140 kDa, is an interferon inducible nuclear leukocyte-specific protein involved in primary biliary cirrhosis and a risk factor in chronic lymphocytic leukemia. It is also implicated in innate immune response to human immunodeficiency virus type 1 (HIV-1) by binding to the virus's viral infectivity factor (Vif) protein. Sp140 contains a nuclear localization signal, a dimerization domain (HSR or CARD domain), a SAND domain, a PHD finger, and a BRD.


Pssm-ID: 277096  Cd Length: 42  Bit Score: 58.59  E-value: 2.62e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1191843223 458 ECEVCCGGGLLLCCDTCPRAFHENCHIPPAVAKRRPWSCTFC 499
Cdd:cd15626     1 KCEVCGQEGKLFCCCTCSRVFHEDCHIPPVEAQRSPWSCTFC 42
PHA03247 PHA03247
large tegument protein UL36; Provisional
 130-363 7.76e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 7.76e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  130 APASTAERSSVRPLLPLPACQGPPPSGPSLVPSVSEPAAPVQPSTEilPKPPSPAGLAKTPPGIIQEGRLTPVSSDSLIL 209
Cdd:PHA03247  2721 LPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGP--PAPAPPAAPAAGPPRRLTRPAVASLSESRESL 2798

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  210 QTEDKEDTPEVPCTPSGSA--PAIKDDSPKPHDPEELQEAPRMPPNKKGKKKKRCIWATP----KRRHKKKCLPREGALP 283
Cdd:PHA03247  2799 PSPWDPADPPAAVLAPAAAlpPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAP 2878

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  284 DHGIQEKLQ--GVDQETQRKddstgnaevmtTAPKTKPKCARTLKPEETTDDIPEVVEEKRPQEPPSRPTRTANKEKPKD 361
Cdd:PHA03247  2879 ARPPVRRLArpAVSRSTESF-----------ALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTT 2947


                   ..
gi 1191843223  362 KT 363
Cdd:PHA03247  2948 DP 2949
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 529-599 1.40e-06

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 46.54  E-value: 1.40e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1191843223 529 CEFLLLKAYCHPQSSFFAET--PRNIQDYGEPFKEAMWLDLVKERLTERVY-TVAWFLRDMRLIFRNHQMFYKA 599
Cdd:pfam00439   1 CLEILDKLMEHPIAAPFLEPvdPDEYPDYYSVIKKPMDLSTIKKKLENGEYkSLAEFLADVKLIFSNARTYNGP 74
KLF9_13_N-like cd21975
Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like ...
 121-251 1.45e-03

Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF9, KLF13, KLF14, KLF16, and similar proteins.


Pssm-ID: 409240 [Multi-domain]  Cd Length: 163  Bit Score: 39.67  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 121 SRSAAAPQEAPASTAERSsvrpllplpacqgPPPSGPSLVPSVSEPAAPVQPSTEILPKPPSPAGLAKTPPGIIQEGRLT 200
Cdd:cd21975    11 SISAGAVVHGVRPDPEGA-------------GLAAGLDVRATREVAKGPGPPGPAWKPDGADSPGLVTAAPHLLAANVLA 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1191843223 201 PVSSDSLILQTEDKEDTPEVPCTPSGSAPAikddSPKPHDPEELQEAPRMP 251
Cdd:cd21975    78 PLRGPSVEGSSLESGDADMGSDSDVAPASG----AAASTSPESSSDAASSP 124
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 125-252 1.64e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.68  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 125 AAPQEAPASTAERSsvrplLPLPACQGPPPSGPSLVPSVSE-PAAPVQP--STEILPKPPSPAGLAKTPPGIIQEGRLTP 201
Cdd:pfam03154 426 PPPAQPPVLTQSQS-----LPPPAASHPPTSGLHQVPSQSPfPQHPFVPggPPPITPPSGPPTSTSSAMPGIQPPSSASV 500

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1191843223 202 VSSDSlilqtedkedtpeVPCTPSGSAPAIK------DDSPKPHDPEELQEAPRMPP 252
Cdd:pfam03154 501 SSSGP-------------VPAAVSCPLPPVQikeealDEAEEPESPPPPPRSPSPEP 544
PHD pfam00628
PHD-finger; PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar ...
 472-502 3.72e-03

PHD-finger; PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar manner to that of the RING and FYVE domains. Several PHD fingers have been identified as binding modules of methylated histone H3.


Pssm-ID: 425785 [Multi-domain]  Cd Length: 51  Bit Score: 35.93  E-value: 3.72e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1191843223 472 DTCPRAFHENCHIPPAVAKRRP---WSCTFCRMR 502
Cdd:pfam00628  18 DGCDDWFHLACLGPPLDPAEIPsgeWLCPECKPK 51
 
Name Accession Description Interval E-value
HSR pfam03172
HSR domain; The Sp100 protein is a constituent of nuclear domains, also known as nuclear dots ...
 15-113 1.31e-59

HSR domain; The Sp100 protein is a constituent of nuclear domains, also known as nuclear dots (NDs). An ND-targeting region that coincides with a homodimerization domain was mapped in Sp100. Sequences similar to the Sp100 homodimerization/ND-targeting region occur in several other proteins and constitute a novel protein motif, termed HSR domain (for homogeneously-staining region). The HSR domain has also been named ASS (AIRE, Sp-100 and Sp140). This domain is usually found at the amino terminus of proteins that contain a SAND domain pfam01342.


Pssm-ID: 460835  Cd Length: 99  Bit Score: 193.91  E-value: 1.31e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  15 LEEALFQHFIHQKLEIAYAINKPFPFFEGLRDNNFITDTLYRESLEACRNLVPVSRVVYNILTKLEKTFSLSFLEMLFGH 94
Cdd:pfam03172   1 LEEALFQHFKENKVEIAYAIKKPFPFLEGLRDHSFITEKMYKESLEACRNLVPVQRVVYNVLSELEKTFSLSLLEALFSD 80

                          90
                  ....*....|....*....
gi 1191843223  95 INLYEYPSLMAVFKSFKNV 113
Cdd:pfam03172  81 VNLKEYPDLIEILKSFPNV 99
Bromo_SP100C_like cd05501
Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major ...
 523-621 2.53e-45

Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin level. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99933  Cd Length: 102  Bit Score: 156.05  E-value: 2.53e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 523 PEEQLKCEFLLLKAYCHPQSSFFAETPRNIQDYGEPFKEAMWLDLVKERLTERVY-TVAWFLRDMRLIFRNHQMFYKASD 601
Cdd:cd05501     1 PEELLKCEFLLLKVYCMSKSGFFISKPYYIRDYCQGIKEPMWLNKVKERLNERVYhTVEGFVRDMRLIFHNHKLFYKDDD 80

                          90       100
                  ....*....|....*....|
gi 1191843223 602 FGQIGLDLEAEFEKDLKKMF 621
Cdd:cd05501    81 FGQVGITLEKKFEKNFKEVF 100
SAND pfam01342
SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The ...
 365-441 2.96e-36

SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The conserved KDWK motif is necessary for DNA binding, and it appears to be important for dimerization. This region is also found in the putative transcription factor RegA from the multicellular green alga Volvox cateri. This region of RegA is known as the VARL domain.


Pssm-ID: 460167  Cd Length: 76  Bit Score: 130.01  E-value: 2.96e-36
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1191843223 365 DFHSLILPVTCGEAKGILYKEKMKLGSSEKCIQNEeGVWFTPREFEIEGKQKHKKYWKRSVLCGGKTLEHLIKKGLL 441
Cdd:pfam01342   1 DFDSPVLPVTCGAAKGLLHKKKFKQGISGKCIQNE-DSWLTPKEFEIEGGKASSKDWKRSIRCGGKPLRELIEKGLL 76
SAND smart00258
SAND domain;
370-441 1.02e-23

SAND domain;


Pssm-ID: 128554  Cd Length: 73  Bit Score: 94.72  E-value: 1.02e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1191843223  370 ILPVTCGEAKGILYKEKMKLGSSEKCIQNEEGvWFTPREFEIEGKQKHKKYWKRSVLCGGKTLEHLIKKGLL 441
Cdd:smart00258   2 ELPVTCGTVKGILYKKKFKCGISVKCIQYEDK-WFTPKEFEIEGGKGKSKDWKRSIRCGGSSLRTLMENGTL 72
BROMO smart00297
bromo domain;
523-620 2.79e-13

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 66.15  E-value: 2.79e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  523 PEEQLKCEFLLLKAYC----HPQSSFFAE--TPRNIQDYGEPFKEAMWLDLVKERLTERVYTVAW-FLRDMRLIFRNHQM 595
Cdd:smart00297   2 PKLQKKLQELLKAVLDkldsHPLSWPFLKpvSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEeFVADFNLMFSNART 81

                           90       100
                   ....*....|....*....|....*.
gi 1191843223  596 FY-KASDFGQIGLDLEAEFEKDLKKM 620
Cdd:smart00297  82 YNgPDSEVYKDAKKLEKFFEKKLREL 107
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 523-621 5.87e-13

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 65.39  E-value: 5.87e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 523 PEEQLKCEFLLLKAYCHPQSSFFAE-TPRNIQDYGEPFKEAMWLDLVKERLTERVY----TVAWFLRDMRLIFRNHQMFY 597
Cdd:cd05502     3 PIDQRKCERLLLELYCHELSLPFHEpVSPSVPNYYKIIKTPMDLSLIRKKLQPKSPqhysSPEEFVADVRLMFKNCYKFN 82

                          90       100
                  ....*....|....*....|....*
gi 1191843223 598 K-ASDFGQIGLDLEAEFEKDLKKMF 621
Cdd:cd05502    83 EeDSEVAQAGKELELFFEEQLKEIL 107
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 525-617 1.98e-12

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 63.55  E-value: 1.98e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 525 EQLKCEFLL--LKAYCHPQSSFFAE--TPRNIQDYGEPFKEAMWLDLVKERLTERVYTVAW-FLRDMRLIFRNHQMFYKA 599
Cdd:cd04369     1 LKKKLRSLLdaLKKLKRDLSEPFLEpvDPKEAPDYYEVIKNPMDLSTIKKKLKNGEYKSLEeFEADVRLIFSNAKTYNGP 80

                          90
                  ....*....|....*....
gi 1191843223 600 -SDFGQIGLDLEAEFEKDL 617
Cdd:cd04369    81 gSPIYKDAKKLEKLFEKLL 99
PHD_SP110_140 cd15626
PHD finger found in the Sp100/Sp140 family of nuclear body components; The Sp100/Sp140 family ...
 458-499 2.62e-11

PHD finger found in the Sp100/Sp140 family of nuclear body components; The Sp100/Sp140 family includes nuclear body proteins SP100, SP140, and similar proteins. Sp110, also termed interferon-induced protein 41/75, or speckled 110 kDa, or transcriptional coactivator Sp110, is a leukocyte-specific component of the nuclear body. It may function as a nuclear hormone receptor transcriptional coactivator that may play a role in inducing differentiation of myeloid cells. It is also involved in resisting intracellular pathogens and functions as an important drug target for preventing intracellular pathogen diseases, such as tuberculosis, hepatic veno-occlusive disease, and intracellular cancers. Sp110 gene polymorphisms may be associated with susceptibility to tuberculosis in Chinese population. Sp110 contains a Sp100-like domain, a SAND domain, a plant homeodomain (PHD) finger, and a bromodomain (BRD). SP140, also termed lymphoid-restricted homolog of Sp100 (LYSp100), or nuclear autoantigen Sp-140, or speckled 140 kDa, is an interferon inducible nuclear leukocyte-specific protein involved in primary biliary cirrhosis and a risk factor in chronic lymphocytic leukemia. It is also implicated in innate immune response to human immunodeficiency virus type 1 (HIV-1) by binding to the virus's viral infectivity factor (Vif) protein. Sp140 contains a nuclear localization signal, a dimerization domain (HSR or CARD domain), a SAND domain, a PHD finger, and a BRD.


Pssm-ID: 277096  Cd Length: 42  Bit Score: 58.59  E-value: 2.62e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1191843223 458 ECEVCCGGGLLLCCDTCPRAFHENCHIPPAVAKRRPWSCTFC 499
Cdd:cd15626     1 KCEVCGQEGKLFCCCTCSRVFHEDCHIPPVEAQRSPWSCTFC 42
PHD_TIF1_like cd15541
PHD finger found in the transcriptional intermediary factor 1 (TIF1) family and similar ...
 472-499 1.01e-07

PHD finger found in the transcriptional intermediary factor 1 (TIF1) family and similar proteins; The TIF1 family of transcriptional cofactors includes TIF1alpha (TRIM24), TIF1beta (TRIM28), TIF1gamma (TRIM33), and TIF1delta (TRIM66), which are characterized by an N-terminal RING-finger B-box coiled-coil (RBCC/TRIM) motif and plant homeodomain (PHD) finger followed by a bromodomain in the C-terminal region. TIF1 proteins couple chromatin modifications to transcriptional regulation, signaling, and tumor suppression. They exert a deacetylase-dependent silencing effect when tethered to a promoter region. TIF1alpha, TIF1beta, and TIF1delta can homodimerize and contain a PXVXL motif necessary and sufficient for heterochromatin protein 1(HP1) binding. TIF1alpha and TIF1beta bind nuclear receptors and Kruppel-associated boxes (KRAB) specifically and respectively. In contrast, TIF1delta appears to lack nuclear receptor- and KRAB-binding activity. Moreover, TIF1delta is specifically involved in heterochromatin-mediated gene silencing during postmeiotic phases of spermatogenesis. TIF1gamma is structurally closely related to TIF1alpha and TIF1beta, but has very little functional features in common with them. It does not interact with the KRAB silencing domain of KOX1 or the heterochromatinic proteins HP1alpha, beta, and gamma. It cannot bind to nuclear receptors (NRs). This family also includes Sp100/Sp140 family proteins, the nuclear body SP100 and SP140. Sp110 is a leukocyte-specific component of the nuclear body. It may function as a nuclear hormone receptor transcriptional coactivator that may play a role in inducing differentiation of myeloid cells. It is also involved in resisting intracellular pathogens and functions as an important drug target for preventing intracellular pathogen diseases, such as tuberculosis, hepatic veno-occlusive disease, and intracellular cancers. SP140 is an interferon inducible nuclear leukocyte-specific protein involved in primary biliary cirrhosis and a risk factor in chronic lymphocytic leukemia. It is also implicated in innate immune response to human immunodeficiency virus type 1 (HIV-1) by binding to the virus viral infectivity factor (Vif) protein. Both Sp110 and Sp140 contain a SAND domain, a plant homeodomain (PHD) finger, and a bromodomain (BRD).


Pssm-ID: 277016 [Multi-domain]  Cd Length: 43  Bit Score: 48.49  E-value: 1.01e-07
                          10        20
                  ....*....|....*....|....*....
gi 1191843223 472 DTCPRAFHENCHIPPAVAK-RRPWSCTFC 499
Cdd:cd15541    15 DKCPRVFHLDCHIPPIPEFpSGEWSCSLC 43
PHA03247 PHA03247
large tegument protein UL36; Provisional
 130-363 7.76e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.63  E-value: 7.76e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  130 APASTAERSSVRPLLPLPACQGPPPSGPSLVPSVSEPAAPVQPSTEilPKPPSPAGLAKTPPGIIQEGRLTPVSSDSLIL 209
Cdd:PHA03247  2721 LPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGP--PAPAPPAAPAAGPPRRLTRPAVASLSESRESL 2798

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  210 QTEDKEDTPEVPCTPSGSA--PAIKDDSPKPHDPEELQEAPRMPPNKKGKKKKRCIWATP----KRRHKKKCLPREGALP 283
Cdd:PHA03247  2799 PSPWDPADPPAAVLAPAAAlpPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAP 2878

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  284 DHGIQEKLQ--GVDQETQRKddstgnaevmtTAPKTKPKCARTLKPEETTDDIPEVVEEKRPQEPPSRPTRTANKEKPKD 361
Cdd:PHA03247  2879 ARPPVRRLArpAVSRSTESF-----------ALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTT 2947


                   ..
gi 1191843223  362 KT 363
Cdd:PHA03247  2948 DP 2949
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 529-599 1.40e-06

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 46.54  E-value: 1.40e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1191843223 529 CEFLLLKAYCHPQSSFFAET--PRNIQDYGEPFKEAMWLDLVKERLTERVY-TVAWFLRDMRLIFRNHQMFYKA 599
Cdd:pfam00439   1 CLEILDKLMEHPIAAPFLEPvdPDEYPDYYSVIKKPMDLSTIKKKLENGEYkSLAEFLADVKLIFSNARTYNGP 74
PHA03247 PHA03247
large tegument protein UL36; Provisional
 124-372 3.16e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 3.16e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  124 AAAPQEAPASTAERSSVRPLLPLPACQGP----PPSGPSLVPSVSEPAAPVQPSTEILPKPPSPAGLAKTPpgiiqegrl 199
Cdd:PHA03247  2738 APAPPAVPAGPATPGGPARPARPPTTAGPpapaPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPP--------- 2808

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  200 TPVSSDSLILQTEDKEDTPEVPCT-PSGSAPAIKDDSPKPHDPEELQEAP-----RMPPNKKGKKKKRCIWATPKRRHKK 273
Cdd:PHA03247  2809 AAVLAPAAALPPAASPAGPLPPPTsAQPTAPPPPPGPPPPSLPLGGSVAPggdvrRRPPSRSPAAKPAAPARPPVRRLAR 2888

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  274 KCLPREG---ALPDHGIQEKLQGVDQETQRKDDSTGNAEVMTTAPKTKPKCARTLKPEETTDDIPEV------------- 337
Cdd:PHA03247  2889 PAVSRSTesfALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPsgavpqpwlgalv 2968

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1191843223  338 ---VEEKRPQEPPSRPTRtankEKPKDKTLDFHSLILP 372
Cdd:PHA03247  2969 pgrVAVPRFRVPQPAPSR----EAPASSTPPLTGHSLS 3002
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 120-360 1.27e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 48.53  E-value: 1.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 120 WSRSAAAPQEAPASTAERSSVRPLLP--LPACQGPPPSGPSLVPSV--SEPAAPVQPSTEilPKPPSPAGLAKTPPGIIQ 195
Cdd:PTZ00449  679 YLDAAAKSKETKTTVVLDESFESILKetLPETPGTPFTTPRPLPPKlpRDEEFPFEPIGD--PDAEQPDDIEFFTPPEEE 756

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 196 EGRLTPVSSDSLILQTEDKE-DTPEVPC-TPSGSAPAIKDDSPKPHDPEELQEAPRMPpnkkgkkkkrciwaTPKRRHKK 273
Cdd:PTZ00449  757 RTFFHETPADTPLPDILAEEfKEEDIHAeTGEPDEAMKRPDSPSEHEDKPPGDHPSLP--------------KKRHRLDG 822

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 274 KCLPREGALPDHGIQEKLQGVDQETQRKDDSTGNAEVMTTAPKTKPKCARTLKPEETTDDIPE-----------VVEEKR 342
Cdd:PTZ00449  823 LALSTTDLESDAGRIAKDASGKIVKLKRSKSFDDLTTVEEAEEMGAEARKIVVDDDGTEADDEdthppeekhksEVRRRR 902

                         250
                  ....*....|....*...
gi 1191843223 343 PQEPPSRPTRTANKEKPK 360
Cdd:PTZ00449  903 PPKKPSKPKKPSKPKKPK 920
PHA03247 PHA03247
large tegument protein UL36; Provisional
 116-304 1.28e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 1.28e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  116 SHRGWSRSAAAPQEAPASTAERSSVRPLLPLPACQGP-PPSGPSLVPsvsEPAAPVQP-STEILPKPPSPAGLAKTPPgi 193
Cdd:PHA03247  2863 RRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAlPPDQPERPP---QPQAPPPPqPQPQPPPPPQPQPPPPPPP-- 2937

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  194 IQEGRLTPVSSDSLILQTEDKEDTPEVPCTPSGSAPAIKDDSPKPHDPEELqEAPRMPPNKKGKKKKRCIWATPKRRHKK 273
Cdd:PHA03247  2938 RPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREA-PASSTPPLTGHSLSRVSSWASSLALHEE 3016

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1191843223  274 KCLPREGALPDHGIQEKLQGVDQETQRKDDS 304
Cdd:PHA03247  3017 TDPPPVSLKQTLWPPDDTEDSDADSLFDSDS 3047
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 75-241 1.08e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 45.44  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  75 ILTKLEKTFSLSFLEMlfghiNLYEYPSLMAVfksfKNVVTSHRGWSRSAAAPQEAPASTAERSsvrplLPLPACQGPPP 154
Cdd:PRK14959  342 VLTSLEPAMALELLLL-----NLAMLPRLMPV----ESLRPSGGGASAPSGSAAEGPASGGAAT-----IPTPGTQGPQG 407

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 155 SGP--SLVPSVSEPAAPVQ--------PSTEILPKPPSPAGLAKTPPGIiqeGRLTPVSSdslilqtedkedTPEVPCTP 224
Cdd:PRK14959  408 TAPaaGMTPSSAAPATPAPsaapsprvPWDDAPPAPPRSGIPPRPAPRM---PEASPVPG------------APDSVASA 472

                         170
                  ....*....|....*...
gi 1191843223 225 SGSAPAIKD-DSPKPHDP 241
Cdd:PRK14959  473 SDAPPTLGDpSDTAEHTP 490
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
125-374 1.31e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 45.25  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 125 AAPqeAPASTAERSSVRPLLPLPACQGPPPSGPSLVPSVSEPAAPVQPSTEILPKPPSPAGLAKTPPGIIQEGRLTPVSs 204
Cdd:PRK12323  372 AGP--ATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAP- 448

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 205 dslilqtedkEDTPEVPCTPSGSAPAIKDDSPKPHDPEELQEAPRMPPNKKGkkkkrciwATPKRRHKKKCLPREGALPD 284
Cdd:PRK12323  449 ----------APAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPA--------PADDDPPPWEELPPEFASPA 510

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 285 HGIQEKLQGVDQETQRKDDSTGNAevmttapktkPKCARTLKPEETTDDIPEVVEEKRPQEPPsRPTRTANKEKPKDKTL 364
Cdd:PRK12323  511 PAQPDAAPAGWVAESIPDPATADP----------DDAFETLAPAPAAAPAPRAAAATEPVVAP-RPPRASASGLPDMFDG 579

                         250
                  ....*....|..
gi 1191843223 365 DFHSLI--LPVT 374
Cdd:PRK12323  580 DWPALAarLPVR 591
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 551-617 2.77e-04

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 40.37  E-value: 2.77e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1191843223 551 NIQDYGEPFKEAMWLDLVKERLTERVYT-VAWFLRDMRLIFRNHQMFY-KASDFGQIGLDLEAEFEKDL 617
Cdd:cd05500    35 NIPHYPTIIKKPMDLGTIERKLKSNVYTsVEEFTADFNLMVDNCLTFNgPEHPVSQMGKRLQAAFEKHL 103
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 122-368 3.00e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.91  E-value: 3.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 122 RSAAAPQEAPASTAERSSVRP-LLPLPACQGPP--PSGPSLVPSVSEPAAPVQPSTEILPKPPSPAGLAKTP--PGI--- 193
Cdd:PTZ00449  595 KKPKRPRSAQRPTRPKSPKLPeLLDIPKSPKRPesPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPKPPfdPKFkek 674

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 194 -----------IQEGRLTPVSSDSliLQTEDKEDTPEVPCTPSGSAPAIkddSPK-PHDPEELQEAPRMPPNKKGKKKKR 261
Cdd:PTZ00449  675 fyddyldaaakSKETKTTVVLDES--FESILKETLPETPGTPFTTPRPL---PPKlPRDEEFPFEPIGDPDAEQPDDIEF 749

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 262 CIWATPKRRHKKKClPREGALPDhgiqeklqgvdqetqrkddstgnaeVMTTAPKTKPKCARTLKPEETTD--DIPEVVE 339
Cdd:PTZ00449  750 FTPPEEERTFFHET-PADTPLPD-------------------------ILAEEFKEEDIHAETGEPDEAMKrpDSPSEHE 803

                         250       260
                  ....*....|....*....|....*....
gi 1191843223 340 EKRPQEPPSRPTRTANKEKPKDKTLDFHS 368
Cdd:PTZ00449  804 DKPPGDHPSLPKKRHRLDGLALSTTDLES 832
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 99-230 4.33e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.16  E-value: 4.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  99 EYPSL-MAVFK--SFK--NVVTSHRGWSRSAAAPQEAPASTAERSSVRPLLPLPAcqgPPPSGPSLVPSVSEPA---APV 170
Cdd:PRK14951  350 EYAALtMVLLRllAFKpaAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPA---AAPAAAASAPAAPPAAappAPV 426

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 171 QPSTEILPKPPSPAGLAKTPPGIIQEGRLTPVSSdSLILQTEDKEDTPEVPCTPSGSAPA 230
Cdd:PRK14951  427 AAPAAAAPAAAPAAAPAAVALAPAPPAQAAPETV-AIPVRVAPEPAVASAAPAPAAAPAA 485
PHA03247 PHA03247
large tegument protein UL36; Provisional
 123-252 4.55e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 4.55e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  123 SAAAPQEAPASTAERSSVRPLLPLPACQGPPPSGPSLVPSvSEPAAPVQPSTE----ILPKPP----SPAGLAKTPPGII 194
Cdd:PHA03247  2800 SPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAP-PPPPGPPPPSLPlggsVAPGGDvrrrPPSRSPAAKPAAP 2878

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1191843223  195 QEGRLTPVSSDSLILQTED---KEDTPEVPCTPSGSAPAIkdDSPKPHDPEELQEAPRMPP 252
Cdd:PHA03247  2879 ARPPVRRLARPAVSRSTESfalPPDQPERPPQPQAPPPPQ--PQPQPPPPPQPQPPPPPPP 2937
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 83-253 5.62e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 43.16  E-value: 5.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  83 FSLSFLEMLFGHINLYEYPSLMAVFKSFKNVVTSHRGWSRSAAA--PQEAPASTAERSSVRpllpLPACQGPPPSGPSLV 160
Cdd:PRK08691  348 FMMTLLRMLAFAPLAAASCDANAVIENTELQSPSAQTAEKETAAkkPQPRPEAETAQTPVQ----TASAAAMPSEGKTAG 423

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 161 PSVSEPAAPVQPSTEILPKPPSPAGLAKTPPGIIQEGR--LTPVSSDSLILQTEDKEDTPEVPCTPSgSAPAIKDDSPKP 238
Cdd:PRK08691  424 PVSNQENNDVPPWEDAPDEAQTAAGTAQTSAKSIQTASeaETPPENQVSKNKAADNETDAPLSEVPS-ENPIQATPNDEA 502

                         170
                  ....*....|....*.
gi 1191843223 239 HDPEEL-QEAPRMPPN 253
Cdd:PRK08691  503 VETETFaHEAPAEPFY 518
PRK13729 PRK13729
conjugal transfer pilus assembly protein TraB; Provisional
 125-231 6.03e-04

conjugal transfer pilus assembly protein TraB; Provisional


Pssm-ID: 184281 [Multi-domain]  Cd Length: 475  Bit Score: 42.89  E-value: 6.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 125 AAPQEAPASTAERSSVRPLLPLPAcqgpPPSGPSLVPSVSEPAAPVQPSTEILPKPPSP--AGLAKTPPGIIQ-EGRLTP 201
Cdd:PRK13729  117 AEQVKALGANPVTATGEPVPQMPA----SPPGPEGEPQPGNTPVSFPPQGSVAVPPPTAfyPGNGVTPPPQVTyQSVPVP 192

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1191843223 202 VSSDSLILQTEDKEDTPEVPCTPSGS-APAI 231
Cdd:PRK13729  193 NRIQRKTFTYNEGKKGPSLPYIPSGSfAKAM 223
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
144-299 7.75e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 42.46  E-value: 7.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 144 LPLPACQGPPPSGP--SLVPSVSEPAAPVQPSTEILPKP-PSPAGLAKTPPgiiqegrltpvssdslilqtedkedTPEV 220
Cdd:PRK14971  362 LTQKGDDASGGRGPkqHIKPVFTQPAAAPQPSAAAAASPsPSQSSAAAQPS-------------------------APQS 416

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1191843223 221 PCTPSGSAPAIKDDSPKPhdpeelqeAPRMPPNKKGKKKKRCIWATPKRRHKKKcLPREGALPDHGIQEKLQGVDQETQ 299
Cdd:PRK14971  417 ATQPAGTPPTVSVDPPAA--------VPVNPPSTAPQAVRPAQFKEEKKIPVSK-VSSLGPSTLRPIQEKAEQATGNIK 486
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 123-251 8.10e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.39  E-value: 8.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 123 SAAAPQEAPASTAerSSVRPLLPLPACQGPPPSGPSLVPSVSEPAAPVQPSTEILPKPPSPAGlakTPPGIIQEGRLTPV 202
Cdd:PRK14951  367 AAAAEAAAPAEKK--TPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVA---APAAAAPAAAPAAA 441

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1191843223 203 SSDSLILQTEDKEDTPEVPCTPSGSAPAIKDDSPKPHDPEELQEAPRMP 251
Cdd:PRK14951  442 PAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTP 490
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
118-251 1.03e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.17  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 118 RGWSRSAAAPQEAPASTAERSSVRPLLPLPACQGPPPSGPSLVPSVSEPAAPVQPSTEILPK-PPSPAGLAKTPPGIIQE 196
Cdd:PRK12323  437 RQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPwEELPPEFASPAPAQPDA 516

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1191843223 197 GRLTPVSSDSLILQTEDKEDTPEVPCTPSGSAPAikddsPKPHDPEELQEAPRMP 251
Cdd:PRK12323  517 APAGWVAESIPDPATADPDDAFETLAPAPAAAPA-----PRAAAATEPVVAPRPP 566
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 529-615 1.38e-03

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 38.51  E-value: 1.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 529 CEFLLLKAYCHPQSSFFAE--TPRNIQDYGEPFKEAMWLDLVKERLTERVY-TVAWFLRDMRLIFRNHQMFYK-ASDFGQ 604
Cdd:cd05503     5 CETILDEMEAHEDAWPFLEpvNTKLVPGYRKIIKKPMDFSTIREKLESGQYkTLEEFAEDVRLVFDNCETFNEdDSEVGR 84

                          90
                  ....*....|.
gi 1191843223 605 IGLDLEAEFEK 615
Cdd:cd05503    85 AGHNMRKFFEK 95
KLF9_13_N-like cd21975
Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like ...
 121-251 1.45e-03

Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF9, KLF13, KLF14, KLF16, and similar proteins.


Pssm-ID: 409240 [Multi-domain]  Cd Length: 163  Bit Score: 39.67  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 121 SRSAAAPQEAPASTAERSsvrpllplpacqgPPPSGPSLVPSVSEPAAPVQPSTEILPKPPSPAGLAKTPPGIIQEGRLT 200
Cdd:cd21975    11 SISAGAVVHGVRPDPEGA-------------GLAAGLDVRATREVAKGPGPPGPAWKPDGADSPGLVTAAPHLLAANVLA 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1191843223 201 PVSSDSLILQTEDKEDTPEVPCTPSGSAPAikddSPKPHDPEELQEAPRMP 251
Cdd:cd21975    78 PLRGPSVEGSSLESGDADMGSDSDVAPASG----AAASTSPESSSDAASSP 124
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 125-252 1.64e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.68  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 125 AAPQEAPASTAERSsvrplLPLPACQGPPPSGPSLVPSVSE-PAAPVQP--STEILPKPPSPAGLAKTPPGIIQEGRLTP 201
Cdd:pfam03154 426 PPPAQPPVLTQSQS-----LPPPAASHPPTSGLHQVPSQSPfPQHPFVPggPPPITPPSGPPTSTSSAMPGIQPPSSASV 500

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1191843223 202 VSSDSlilqtedkedtpeVPCTPSGSAPAIK------DDSPKPHDPEELQEAPRMPP 252
Cdd:pfam03154 501 SSSGP-------------VPAAVSCPLPPVQikeealDEAEEPESPPPPPRSPSPEP 544
PHA03247 PHA03247
large tegument protein UL36; Provisional
 115-238 1.70e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 1.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  115 TSHRGWSRSAAAPQEAPASTAERSSVRPLLPLPAcqgPPPSGPslvpsvsEPAAPVQPSTEILPKPPSPAGLAKTPPGII 194
Cdd:PHA03247  2667 ARRLGRAAQASSPPQRPRRRAARPTVGSLTSLAD---PPPPPP-------TPEPAPHALVSATPLPPGPAAARQASPALP 2736

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1191843223  195 QEGRLTPVSSDSLILQTEDKEDTPEVPCTPSGSAPAIKDDSPKP 238
Cdd:PHA03247  2737 AAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPP 2780
PHA03247 PHA03247
large tegument protein UL36; Provisional
 122-351 1.73e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 1.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  122 RSAAAPQEAPASTAERSSVRPLLPLPACQGP-PPSGPSLVPSVSEPAAPVQPSTEILPKPPSPAGLAKTPPGIIQEGRLT 200
Cdd:PHA03247  2653 RDDPAPGRVSRPRRARRLGRAAQASSPPQRPrRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQAS 2732

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  201 PVSSDSLILQTedkedTPEVPCTPSGSAPAIKDDSPK-PHDPeelqEAPRMPPNKKGKKKKRCIWATPKRRHKKKCLPRE 279
Cdd:PHA03247  2733 PALPAAPAPPA-----VPAGPATPGGPARPARPPTTAgPPAP----APPAAPAAGPPRRLTRPAVASLSESRESLPSPWD 2803

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1191843223  280 GALPDHGIQEKLQGVDQETQRKDDSTGNAEVMTTAP-KTKPKCARTLKPEETTDDIPEVVEEKRPQEPPSRPT 351
Cdd:PHA03247  2804 PADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPpPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPA 2876
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 111-252 2.32e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.29  E-value: 2.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 111 KNVVTSHRGWSRSAAAPQEAPA---STAERSSVRPLLPLPACQGPPPSGPSLVPS--VSEPAAPVQPSTEILPKPPSPag 185
Cdd:pfam03154 135 KDIDQDNRSTSPSIPSPQDNESdsdSSAQQQILQTQPPVLQAQSGAASPPSPPPPgtTQAATAGPTPSAPSVPPQGSP-- 212

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1191843223 186 lAKTPPGIIQEGRLTPVssdSLILQT----EDKEDTPEVPCTPSGSAPAIKDDSPKPHDPEELQEapRMPP 252
Cdd:pfam03154 213 -ATSQPPNQTQSTAAPH---TLIQQTptlhPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHG--QMPP 277
PHA03247 PHA03247
large tegument protein UL36; Provisional
 126-359 2.36e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 2.36e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  126 APQEAPASTAERSsvrplLPLPACqGPPPSGPSLVPSVSEPAAPVQPSTeilpkPPSPAGLAKTPPGIIQEGRLTPvssd 205
Cdd:PHA03247  2555 LPPAAPPAAPDRS-----VPPPRP-APRPSEPAVTSRARRPDAPPQSAR-----PRAPVDDRGDPRGPAPPSPLPP---- 2619

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  206 slilqtedkEDTPEVPCTPSGSAPAIKDD------SPKPHDPEELQEAPRMPPNKKGKKKKRCIWAT-PKRRhkkkclPR 278
Cdd:PHA03247  2620 ---------DTHAPDPPPPSPSPAANEPDphppptVPPPERPRDDPAPGRVSRPRRARRLGRAAQASsPPQR------PR 2684

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  279 EGALPDHGIQEKLQGVDQETQRKDDSTGNAEVMTTAPKTKPKCARTLKPEETTDDIPEVVEEKR----PQEPPSRPTRTA 354
Cdd:PHA03247  2685 RRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPatpgGPARPARPPTTA 2764


                   ....*
gi 1191843223  355 NKEKP 359
Cdd:PHA03247  2765 GPPAP 2769
PHA03378 PHA03378
EBNA-3B; Provisional
 120-252 2.69e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.82  E-value: 2.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 120 WSRSAAAPqeAPASTAERSSVRPLLPLPACQGPPPSGPSLVPSVSEPAAPVQ-PSTEILPKPPSPAGLAKTPPGIIQEGR 198
Cdd:PHA03378  666 WTQIGHIP--YQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQrPAAATGRARPPAAAPGRARPPAAAPGR 743

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1191843223 199 LTPVSSDSLILQTEDKEDTPEVPCTPSGSAPAikdDSPKPHDPEELQEAPRMPP 252
Cdd:PHA03378  744 ARPPAAAPGRARPPAAAPGRARPPAAAPGAPT---PQPPPQAPPAPQQRPRGAP 794
PHD pfam00628
PHD-finger; PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar ...
 472-502 3.72e-03

PHD-finger; PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar manner to that of the RING and FYVE domains. Several PHD fingers have been identified as binding modules of methylated histone H3.


Pssm-ID: 425785 [Multi-domain]  Cd Length: 51  Bit Score: 35.93  E-value: 3.72e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1191843223 472 DTCPRAFHENCHIPPAVAKRRP---WSCTFCRMR 502
Cdd:pfam00628  18 DGCDDWFHLACLGPPLDPAEIPsgeWLCPECKPK 51
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 123-233 4.22e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 40.18  E-value: 4.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 123 SAAAPQEAPASTAERSSVRPllplpacqGPPPSGPSLVPsVSEPAAPVQPSTEILPKPPSPAGLAKTPPGIIQEGrlTPV 202
Cdd:PRK14950  362 PVPAPQPAKPTAAAPSPVRP--------TPAPSTRPKAA-AAANIPPKEPVRETATPPPVPPRPVAPPVPHTPES--APK 430

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1191843223 203 SSDSLILQTEDKEDTPEVPcTPSGSAPAIKD 233
Cdd:PRK14950  431 LTRAAIPVDEKPKYTPPAP-PKEEEKALIAD 460
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 118-249 4.32e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 4.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 118 RGWSRSAAAPQEAPASTAERSSVRPLLPLPACQ----GPPPSGPSLVPSVSEPAAPVQPSteiLPKPPSPAGLAKTPPGI 193
Cdd:PRK07764  402 AAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPApapaPAPPSPAGNAPAGGAPSPPPAAA---PSAQPAPAPAAAPEPTA 478

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1191843223 194 IQEGRLTPVSSDSlilqtedkeDTPEVPCTPSGSAPAIKDDSPKPHDPEELQEAPR 249
Cdd:PRK07764  479 APAPAPPAAPAPA---------AAPAAPAAPAAPAGADDAATLRERWPEILAAVPK 525
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 121-241 4.53e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 40.18  E-value: 4.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 121 SRSAAAPQEAPASTAERSSVRPLLPLPACQGPPPSGPSLVPSVSEPAAPVQPSTEILPKPPSPAGLAK--TPPGIIQEGR 198
Cdd:PRK14950  375 APSPVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPHTPESAPKLTRAAIPVDEKPkyTPPAPPKEEE 454

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1191843223 199 LTPVSSDSLILQTEdkedtpevpctpsGSAPAIKDDSPkPHDP 241
Cdd:PRK14950  455 KALIADGDVLEQLE-------------AIWKQILRDVP-PRSP 483
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 111-241 4.88e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.15  E-value: 4.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223  111 KNVVTSHRGWSRSAAAPQEAPASTAERSSvrPLLPLPACQGPPPSGPSLVPSVSEPAAPVQPSTEILPKPPSPAGLAKTP 190
Cdd:PHA03307    84 SRSTPTWSLSTLAPASPAREGSPTPPGPS--SPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAA 161

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1191843223  191 PGIIQEGRLTPVSSDSLILQTEDKEDTPEVPCTPSGSAPAIKDDSPKPHDP 241
Cdd:PHA03307   162 VASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSP 212
DUF3729 pfam12526
Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins ...
 118-192 6.30e-03

Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins in this family are typically between 145 and 1707 amino acids in length. The family is found in association with pfam01443, pfam01661, pfam05417, pfam01660, pfam00978. There is a single completely conserved residue L that may be functionally important.


Pssm-ID: 372164 [Multi-domain]  Cd Length: 115  Bit Score: 36.98  E-value: 6.30e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1191843223 118 RGWSRSAAAPQEAPASTAERSSVRPL-LPLPACQGPPPSGPSLV--PSVSEPAAPVQPSTEILPKPPSPAGLAKTPPG 192
Cdd:pfam12526  18 RTWSTSGFSSCFSPPESAHPDPPPPVgDPRPPVVDTPPPVSAVWvlPPPSEPAAPEPDLVPPVTGPAGPPSPLAPPAP 95
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
122-230 9.82e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 39.06  E-value: 9.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843223 122 RSAAAPQEAPASTAERSSVRPLLPLPA-CQGPPPSGPSLVPSVSEPAAPVQPSTEILPKPPSPAGLAK--TPPGIIQEGR 198
Cdd:PRK07003  423 AEAPPAAPAPPATADRGDDAADGDAPVpAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFepAPRAAAPSAA 502

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1191843223 199 LTPVSSDSLILQTEDKEDTPEVPCTPSGSAPA 230
Cdd:PRK07003  503 TPAAVPDARAPAAASREDAPAAAAPPAPEARP 534
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH