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Conserved domains on  [gi|1191843227|ref|XP_020931310|]
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sp110 nuclear body protein isoform X6 [Sus scrofa]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HSR pfam03172
HSR domain; The Sp100 protein is a constituent of nuclear domains, also known as nuclear dots ...
 5-103 2.18e-59

HSR domain; The Sp100 protein is a constituent of nuclear domains, also known as nuclear dots (NDs). An ND-targeting region that coincides with a homodimerization domain was mapped in Sp100. Sequences similar to the Sp100 homodimerization/ND-targeting region occur in several other proteins and constitute a novel protein motif, termed HSR domain (for homogeneously-staining region). The HSR domain has also been named ASS (AIRE, Sp-100 and Sp140). This domain is usually found at the amino terminus of proteins that contain a SAND domain pfam01342.


:

Pssm-ID: 460835  Cd Length: 99  Bit Score: 193.52  E-value: 2.18e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227   5 LEEALFQHFIHQKLEIAYAINKPFPFFEGLRDNNFITDTLYRESLEACRNLVPVSRVVYNILTKLEKTFSLSFLEMLFGH 84
Cdd:pfam03172   1 LEEALFQHFKENKVEIAYAIKKPFPFLEGLRDHSFITEKMYKESLEACRNLVPVQRVVYNVLSELEKTFSLSLLEALFSD 80

                          90
                  ....*....|....*....
gi 1191843227  85 INLYEYPSLMAVFKSFKNV 103
Cdd:pfam03172  81 VNLKEYPDLIEILKSFPNV 99
Bromodomain super family cl02556
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 535-633 4.88e-45

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


The actual alignment was detected with superfamily member cd05501:

Pssm-ID: 445827  Cd Length: 102  Bit Score: 155.28  E-value: 4.88e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 535 PEEQLKCEFLLLKAYCHPQSSFFAETPRNIQDYGEPFKEAMWLDLVKERLTERVY-TVAWFLRDMRLIFRNHQMFYKASD 613
Cdd:cd05501     1 PEELLKCEFLLLKVYCMSKSGFFISKPYYIRDYCQGIKEPMWLNKVKERLNERVYhTVEGFVRDMRLIFHNHKLFYKDDD 80

                          90       100
                  ....*....|....*....|
gi 1191843227 614 FGQIGLDLEAEFEKDLKKMF 633
Cdd:cd05501    81 FGQVGITLEKKFEKNFKEVF 100
SAND pfam01342
SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The ...
 377-453 3.96e-36

SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The conserved KDWK motif is necessary for DNA binding, and it appears to be important for dimerization. This region is also found in the putative transcription factor RegA from the multicellular green alga Volvox cateri. This region of RegA is known as the VARL domain.


:

Pssm-ID: 460167  Cd Length: 76  Bit Score: 130.01  E-value: 3.96e-36
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1191843227 377 DFHSLILPVTCGEAKGILYKEKMKLGSSEKCIQNEeGVWFTPREFEIEGKQKHKKYWKRSVLCGGKTLEHLIKKGLL 453
Cdd:pfam01342   1 DFDSPVLPVTCGAAKGLLHKKKFKQGISGKCIQNE-DSWLTPKEFEIEGGKASSKDWKRSIRCGGKPLRELIEKGLL 76
PHD_SF super family cl22851
PHD finger superfamily; The PHD finger superfamily includes a canonical plant homeodomain (PHD) ...
 470-511 2.62e-11

PHD finger superfamily; The PHD finger superfamily includes a canonical plant homeodomain (PHD) finger typically characterized as Cys4HisCys3, and a non-canonical extended PHD finger, characterized as Cys2HisCys5HisCys2His. Variations include the RAG2 PHD finger characterized by Cys3His2Cys2His and the PHD finger 5 found in nuclear receptor-binding SET domain-containing proteins characterized by Cys4HisCys2His. The PHD finger is also termed LAP (leukemia-associated protein) motif or TTC (trithorax consensus) domain. Single or multiple copies of PHD fingers have been found in a variety of eukaryotic proteins involved in the control of gene transcription and chromatin dynamics. PHD fingers can recognize the unmodified and modified histone H3 tail, and some have been found to interact with non-histone proteins. They also function as epigenome readers controlling gene expression through molecular recruitment of multi-protein complexes of chromatin regulators and transcription factors. The PHD finger domain SF is structurally similar to the RING and FYVE_like superfamilies.


The actual alignment was detected with superfamily member cd15626:

Pssm-ID: 473978  Cd Length: 42  Bit Score: 58.59  E-value: 2.62e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1191843227 470 ECEVCCGGGLLLCCDTCPRAFHENCHIPPAVAKRRPWSCTFC 511
Cdd:cd15626     1 KCEVCGQEGKLFCCCTCSRVFHEDCHIPPVEAQRSPWSCTFC 42
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 120-342 1.03e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.25  E-value: 1.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227  120 APASTAERSSVRPLLPLPACQGPPPSGPSLVPSVSEPAAPVQPSTEilPKPPSPAGLAKTPPGIIQEGRLTPVSSDSLIL 199
Cdd:PHA03247  2721 LPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGP--PAPAPPAAPAAGPPRRLTRPAVASLSESRESL 2798

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227  200 QTEDKEDTPEVPCTPSGSA--PAIKDDSPKPHDPEELQEAPRMPPNKKGKKKKRCIWATP----KRRHKKKCLPREGALP 273
Cdd:PHA03247  2799 PSPWDPADPPAAVLAPAAAlpPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAP 2878

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1191843227  274 DHGIQEKLQ--GVDQETQRKddstgnaevmtTAPKTKPKCARTLKPEETTDDIPEVVEEKRPQEPPSRPTR 342
Cdd:PHA03247  2879 ARPPVRRLArpAVSRSTESF-----------ALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938
 
Name Accession Description Interval E-value
HSR pfam03172
HSR domain; The Sp100 protein is a constituent of nuclear domains, also known as nuclear dots ...
 5-103 2.18e-59

HSR domain; The Sp100 protein is a constituent of nuclear domains, also known as nuclear dots (NDs). An ND-targeting region that coincides with a homodimerization domain was mapped in Sp100. Sequences similar to the Sp100 homodimerization/ND-targeting region occur in several other proteins and constitute a novel protein motif, termed HSR domain (for homogeneously-staining region). The HSR domain has also been named ASS (AIRE, Sp-100 and Sp140). This domain is usually found at the amino terminus of proteins that contain a SAND domain pfam01342.


Pssm-ID: 460835  Cd Length: 99  Bit Score: 193.52  E-value: 2.18e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227   5 LEEALFQHFIHQKLEIAYAINKPFPFFEGLRDNNFITDTLYRESLEACRNLVPVSRVVYNILTKLEKTFSLSFLEMLFGH 84
Cdd:pfam03172   1 LEEALFQHFKENKVEIAYAIKKPFPFLEGLRDHSFITEKMYKESLEACRNLVPVQRVVYNVLSELEKTFSLSLLEALFSD 80

                          90
                  ....*....|....*....
gi 1191843227  85 INLYEYPSLMAVFKSFKNV 103
Cdd:pfam03172  81 VNLKEYPDLIEILKSFPNV 99
Bromo_SP100C_like cd05501
Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major ...
 535-633 4.88e-45

Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin level. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99933  Cd Length: 102  Bit Score: 155.28  E-value: 4.88e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 535 PEEQLKCEFLLLKAYCHPQSSFFAETPRNIQDYGEPFKEAMWLDLVKERLTERVY-TVAWFLRDMRLIFRNHQMFYKASD 613
Cdd:cd05501     1 PEELLKCEFLLLKVYCMSKSGFFISKPYYIRDYCQGIKEPMWLNKVKERLNERVYhTVEGFVRDMRLIFHNHKLFYKDDD 80

                          90       100
                  ....*....|....*....|
gi 1191843227 614 FGQIGLDLEAEFEKDLKKMF 633
Cdd:cd05501    81 FGQVGITLEKKFEKNFKEVF 100
SAND pfam01342
SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The ...
 377-453 3.96e-36

SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The conserved KDWK motif is necessary for DNA binding, and it appears to be important for dimerization. This region is also found in the putative transcription factor RegA from the multicellular green alga Volvox cateri. This region of RegA is known as the VARL domain.


Pssm-ID: 460167  Cd Length: 76  Bit Score: 130.01  E-value: 3.96e-36
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1191843227 377 DFHSLILPVTCGEAKGILYKEKMKLGSSEKCIQNEeGVWFTPREFEIEGKQKHKKYWKRSVLCGGKTLEHLIKKGLL 453
Cdd:pfam01342   1 DFDSPVLPVTCGAAKGLLHKKKFKQGISGKCIQNE-DSWLTPKEFEIEGGKASSKDWKRSIRCGGKPLRELIEKGLL 76
SAND smart00258
SAND domain;
382-453 1.27e-23

SAND domain;


Pssm-ID: 128554  Cd Length: 73  Bit Score: 94.72  E-value: 1.27e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1191843227  382 ILPVTCGEAKGILYKEKMKLGSSEKCIQNEEGvWFTPREFEIEGKQKHKKYWKRSVLCGGKTLEHLIKKGLL 453
Cdd:smart00258   2 ELPVTCGTVKGILYKKKFKCGISVKCIQYEDK-WFTPKEFEIEGGKGKSKDWKRSIRCGGSSLRTLMENGTL 72
BROMO smart00297
bromo domain;
535-632 3.46e-13

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 66.15  E-value: 3.46e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227  535 PEEQLKCEFLLLKAYC----HPQSSFFAE--TPRNIQDYGEPFKEAMWLDLVKERLTERVYTVAW-FLRDMRLIFRNHQM 607
Cdd:smart00297   2 PKLQKKLQELLKAVLDkldsHPLSWPFLKpvSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEeFVADFNLMFSNART 81

                           90       100
                   ....*....|....*....|....*.
gi 1191843227  608 FY-KASDFGQIGLDLEAEFEKDLKKM 632
Cdd:smart00297  82 YNgPDSEVYKDAKKLEKFFEKKLREL 107
PHD_SP110_140 cd15626
PHD finger found in the Sp100/Sp140 family of nuclear body components; The Sp100/Sp140 family ...
 470-511 2.62e-11

PHD finger found in the Sp100/Sp140 family of nuclear body components; The Sp100/Sp140 family includes nuclear body proteins SP100, SP140, and similar proteins. Sp110, also termed interferon-induced protein 41/75, or speckled 110 kDa, or transcriptional coactivator Sp110, is a leukocyte-specific component of the nuclear body. It may function as a nuclear hormone receptor transcriptional coactivator that may play a role in inducing differentiation of myeloid cells. It is also involved in resisting intracellular pathogens and functions as an important drug target for preventing intracellular pathogen diseases, such as tuberculosis, hepatic veno-occlusive disease, and intracellular cancers. Sp110 gene polymorphisms may be associated with susceptibility to tuberculosis in Chinese population. Sp110 contains a Sp100-like domain, a SAND domain, a plant homeodomain (PHD) finger, and a bromodomain (BRD). SP140, also termed lymphoid-restricted homolog of Sp100 (LYSp100), or nuclear autoantigen Sp-140, or speckled 140 kDa, is an interferon inducible nuclear leukocyte-specific protein involved in primary biliary cirrhosis and a risk factor in chronic lymphocytic leukemia. It is also implicated in innate immune response to human immunodeficiency virus type 1 (HIV-1) by binding to the virus's viral infectivity factor (Vif) protein. Sp140 contains a nuclear localization signal, a dimerization domain (HSR or CARD domain), a SAND domain, a PHD finger, and a BRD.


Pssm-ID: 277096  Cd Length: 42  Bit Score: 58.59  E-value: 2.62e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1191843227 470 ECEVCCGGGLLLCCDTCPRAFHENCHIPPAVAKRRPWSCTFC 511
Cdd:cd15626     1 KCEVCGQEGKLFCCCTCSRVFHEDCHIPPVEAQRSPWSCTFC 42
PHA03247 PHA03247
large tegument protein UL36; Provisional
 120-342 1.03e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.25  E-value: 1.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227  120 APASTAERSSVRPLLPLPACQGPPPSGPSLVPSVSEPAAPVQPSTEilPKPPSPAGLAKTPPGIIQEGRLTPVSSDSLIL 199
Cdd:PHA03247  2721 LPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGP--PAPAPPAAPAAGPPRRLTRPAVASLSESRESL 2798

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227  200 QTEDKEDTPEVPCTPSGSA--PAIKDDSPKPHDPEELQEAPRMPPNKKGKKKKRCIWATP----KRRHKKKCLPREGALP 273
Cdd:PHA03247  2799 PSPWDPADPPAAVLAPAAAlpPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAP 2878

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1191843227  274 DHGIQEKLQ--GVDQETQRKddstgnaevmtTAPKTKPKCARTLKPEETTDDIPEVVEEKRPQEPPSRPTR 342
Cdd:PHA03247  2879 ARPPVRRLArpAVSRSTESF-----------ALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 541-611 1.64e-06

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 46.15  E-value: 1.64e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1191843227 541 CEFLLLKAYCHPQSSFFAET--PRNIQDYGEPFKEAMWLDLVKERLTERVY-TVAWFLRDMRLIFRNHQMFYKA 611
Cdd:pfam00439   1 CLEILDKLMEHPIAAPFLEPvdPDEYPDYYSVIKKPMDLSTIKKKLENGEYkSLAEFLADVKLIFSNARTYNGP 74
KLF9_13_N-like cd21975
Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like ...
 111-241 1.41e-03

Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF9, KLF13, KLF14, KLF16, and similar proteins.


Pssm-ID: 409240 [Multi-domain]  Cd Length: 163  Bit Score: 40.06  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 111 SRSAAAPQEAPASTAERSsvrpllplpacqgPPPSGPSLVPSVSEPAAPVQPSTEILPKPPSPAGLAKTPPGIIQEGRLT 190
Cdd:cd21975    11 SISAGAVVHGVRPDPEGA-------------GLAAGLDVRATREVAKGPGPPGPAWKPDGADSPGLVTAAPHLLAANVLA 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1191843227 191 PVSSDSLILQTEDKEDTPEVPCTPSGSAPAikddSPKPHDPEELQEAPRMP 241
Cdd:cd21975    78 PLRGPSVEGSSLESGDADMGSDSDVAPASG----AAASTSPESSSDAASSP 124
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 115-242 1.94e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.29  E-value: 1.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 115 AAPQEAPASTAERSsvrplLPLPACQGPPPSGPSLVPSVSE-PAAPVQP--STEILPKPPSPAGLAKTPPGIIQEGRLTP 191
Cdd:pfam03154 426 PPPAQPPVLTQSQS-----LPPPAASHPPTSGLHQVPSQSPfPQHPFVPggPPPITPPSGPPTSTSSAMPGIQPPSSASV 500

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1191843227 192 VSSDSlilqtedkedtpeVPCTPSGSAPAIK------DDSPKPHDPEELQEAPRMPP 242
Cdd:pfam03154 501 SSSGP-------------VPAAVSCPLPPVQikeealDEAEEPESPPPPPRSPSPEP 544
PHD pfam00628
PHD-finger; PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar ...
 484-514 3.83e-03

PHD-finger; PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar manner to that of the RING and FYVE domains. Several PHD fingers have been identified as binding modules of methylated histone H3.


Pssm-ID: 425785 [Multi-domain]  Cd Length: 51  Bit Score: 35.93  E-value: 3.83e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1191843227 484 DTCPRAFHENCHIPPAVAKRRP---WSCTFCRMR 514
Cdd:pfam00628  18 DGCDDWFHLACLGPPLDPAEIPsgeWLCPECKPK 51
 
Name Accession Description Interval E-value
HSR pfam03172
HSR domain; The Sp100 protein is a constituent of nuclear domains, also known as nuclear dots ...
 5-103 2.18e-59

HSR domain; The Sp100 protein is a constituent of nuclear domains, also known as nuclear dots (NDs). An ND-targeting region that coincides with a homodimerization domain was mapped in Sp100. Sequences similar to the Sp100 homodimerization/ND-targeting region occur in several other proteins and constitute a novel protein motif, termed HSR domain (for homogeneously-staining region). The HSR domain has also been named ASS (AIRE, Sp-100 and Sp140). This domain is usually found at the amino terminus of proteins that contain a SAND domain pfam01342.


Pssm-ID: 460835  Cd Length: 99  Bit Score: 193.52  E-value: 2.18e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227   5 LEEALFQHFIHQKLEIAYAINKPFPFFEGLRDNNFITDTLYRESLEACRNLVPVSRVVYNILTKLEKTFSLSFLEMLFGH 84
Cdd:pfam03172   1 LEEALFQHFKENKVEIAYAIKKPFPFLEGLRDHSFITEKMYKESLEACRNLVPVQRVVYNVLSELEKTFSLSLLEALFSD 80

                          90
                  ....*....|....*....
gi 1191843227  85 INLYEYPSLMAVFKSFKNV 103
Cdd:pfam03172  81 VNLKEYPDLIEILKSFPNV 99
Bromo_SP100C_like cd05501
Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major ...
 535-633 4.88e-45

Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin level. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99933  Cd Length: 102  Bit Score: 155.28  E-value: 4.88e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 535 PEEQLKCEFLLLKAYCHPQSSFFAETPRNIQDYGEPFKEAMWLDLVKERLTERVY-TVAWFLRDMRLIFRNHQMFYKASD 613
Cdd:cd05501     1 PEELLKCEFLLLKVYCMSKSGFFISKPYYIRDYCQGIKEPMWLNKVKERLNERVYhTVEGFVRDMRLIFHNHKLFYKDDD 80

                          90       100
                  ....*....|....*....|
gi 1191843227 614 FGQIGLDLEAEFEKDLKKMF 633
Cdd:cd05501    81 FGQVGITLEKKFEKNFKEVF 100
SAND pfam01342
SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The ...
 377-453 3.96e-36

SAND domain; The DNA binding activity of two proteins has been mapped to the SAND domain. The conserved KDWK motif is necessary for DNA binding, and it appears to be important for dimerization. This region is also found in the putative transcription factor RegA from the multicellular green alga Volvox cateri. This region of RegA is known as the VARL domain.


Pssm-ID: 460167  Cd Length: 76  Bit Score: 130.01  E-value: 3.96e-36
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1191843227 377 DFHSLILPVTCGEAKGILYKEKMKLGSSEKCIQNEeGVWFTPREFEIEGKQKHKKYWKRSVLCGGKTLEHLIKKGLL 453
Cdd:pfam01342   1 DFDSPVLPVTCGAAKGLLHKKKFKQGISGKCIQNE-DSWLTPKEFEIEGGKASSKDWKRSIRCGGKPLRELIEKGLL 76
SAND smart00258
SAND domain;
382-453 1.27e-23

SAND domain;


Pssm-ID: 128554  Cd Length: 73  Bit Score: 94.72  E-value: 1.27e-23
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1191843227  382 ILPVTCGEAKGILYKEKMKLGSSEKCIQNEEGvWFTPREFEIEGKQKHKKYWKRSVLCGGKTLEHLIKKGLL 453
Cdd:smart00258   2 ELPVTCGTVKGILYKKKFKCGISVKCIQYEDK-WFTPKEFEIEGGKGKSKDWKRSIRCGGSSLRTLMENGTL 72
BROMO smart00297
bromo domain;
535-632 3.46e-13

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 66.15  E-value: 3.46e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227  535 PEEQLKCEFLLLKAYC----HPQSSFFAE--TPRNIQDYGEPFKEAMWLDLVKERLTERVYTVAW-FLRDMRLIFRNHQM 607
Cdd:smart00297   2 PKLQKKLQELLKAVLDkldsHPLSWPFLKpvSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEeFVADFNLMFSNART 81

                           90       100
                   ....*....|....*....|....*.
gi 1191843227  608 FY-KASDFGQIGLDLEAEFEKDLKKM 632
Cdd:smart00297  82 YNgPDSEVYKDAKKLEKFFEKKLREL 107
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 535-633 6.67e-13

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 65.39  E-value: 6.67e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 535 PEEQLKCEFLLLKAYCHPQSSFFAE-TPRNIQDYGEPFKEAMWLDLVKERLTERVY----TVAWFLRDMRLIFRNHQMFY 609
Cdd:cd05502     3 PIDQRKCERLLLELYCHELSLPFHEpVSPSVPNYYKIIKTPMDLSLIRKKLQPKSPqhysSPEEFVADVRLMFKNCYKFN 82

                          90       100
                  ....*....|....*....|....*
gi 1191843227 610 K-ASDFGQIGLDLEAEFEKDLKKMF 633
Cdd:cd05502    83 EeDSEVAQAGKELELFFEEQLKEIL 107
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 537-629 2.61e-12

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 63.16  E-value: 2.61e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 537 EQLKCEFLL--LKAYCHPQSSFFAE--TPRNIQDYGEPFKEAMWLDLVKERLTERVYTVAW-FLRDMRLIFRNHQMFYKA 611
Cdd:cd04369     1 LKKKLRSLLdaLKKLKRDLSEPFLEpvDPKEAPDYYEVIKNPMDLSTIKKKLKNGEYKSLEeFEADVRLIFSNAKTYNGP 80

                          90
                  ....*....|....*....
gi 1191843227 612 -SDFGQIGLDLEAEFEKDL 629
Cdd:cd04369    81 gSPIYKDAKKLEKLFEKLL 99
PHD_SP110_140 cd15626
PHD finger found in the Sp100/Sp140 family of nuclear body components; The Sp100/Sp140 family ...
 470-511 2.62e-11

PHD finger found in the Sp100/Sp140 family of nuclear body components; The Sp100/Sp140 family includes nuclear body proteins SP100, SP140, and similar proteins. Sp110, also termed interferon-induced protein 41/75, or speckled 110 kDa, or transcriptional coactivator Sp110, is a leukocyte-specific component of the nuclear body. It may function as a nuclear hormone receptor transcriptional coactivator that may play a role in inducing differentiation of myeloid cells. It is also involved in resisting intracellular pathogens and functions as an important drug target for preventing intracellular pathogen diseases, such as tuberculosis, hepatic veno-occlusive disease, and intracellular cancers. Sp110 gene polymorphisms may be associated with susceptibility to tuberculosis in Chinese population. Sp110 contains a Sp100-like domain, a SAND domain, a plant homeodomain (PHD) finger, and a bromodomain (BRD). SP140, also termed lymphoid-restricted homolog of Sp100 (LYSp100), or nuclear autoantigen Sp-140, or speckled 140 kDa, is an interferon inducible nuclear leukocyte-specific protein involved in primary biliary cirrhosis and a risk factor in chronic lymphocytic leukemia. It is also implicated in innate immune response to human immunodeficiency virus type 1 (HIV-1) by binding to the virus's viral infectivity factor (Vif) protein. Sp140 contains a nuclear localization signal, a dimerization domain (HSR or CARD domain), a SAND domain, a PHD finger, and a BRD.


Pssm-ID: 277096  Cd Length: 42  Bit Score: 58.59  E-value: 2.62e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1191843227 470 ECEVCCGGGLLLCCDTCPRAFHENCHIPPAVAKRRPWSCTFC 511
Cdd:cd15626     1 KCEVCGQEGKLFCCCTCSRVFHEDCHIPPVEAQRSPWSCTFC 42
PHD_TIF1_like cd15541
PHD finger found in the transcriptional intermediary factor 1 (TIF1) family and similar ...
 484-511 1.04e-07

PHD finger found in the transcriptional intermediary factor 1 (TIF1) family and similar proteins; The TIF1 family of transcriptional cofactors includes TIF1alpha (TRIM24), TIF1beta (TRIM28), TIF1gamma (TRIM33), and TIF1delta (TRIM66), which are characterized by an N-terminal RING-finger B-box coiled-coil (RBCC/TRIM) motif and plant homeodomain (PHD) finger followed by a bromodomain in the C-terminal region. TIF1 proteins couple chromatin modifications to transcriptional regulation, signaling, and tumor suppression. They exert a deacetylase-dependent silencing effect when tethered to a promoter region. TIF1alpha, TIF1beta, and TIF1delta can homodimerize and contain a PXVXL motif necessary and sufficient for heterochromatin protein 1(HP1) binding. TIF1alpha and TIF1beta bind nuclear receptors and Kruppel-associated boxes (KRAB) specifically and respectively. In contrast, TIF1delta appears to lack nuclear receptor- and KRAB-binding activity. Moreover, TIF1delta is specifically involved in heterochromatin-mediated gene silencing during postmeiotic phases of spermatogenesis. TIF1gamma is structurally closely related to TIF1alpha and TIF1beta, but has very little functional features in common with them. It does not interact with the KRAB silencing domain of KOX1 or the heterochromatinic proteins HP1alpha, beta, and gamma. It cannot bind to nuclear receptors (NRs). This family also includes Sp100/Sp140 family proteins, the nuclear body SP100 and SP140. Sp110 is a leukocyte-specific component of the nuclear body. It may function as a nuclear hormone receptor transcriptional coactivator that may play a role in inducing differentiation of myeloid cells. It is also involved in resisting intracellular pathogens and functions as an important drug target for preventing intracellular pathogen diseases, such as tuberculosis, hepatic veno-occlusive disease, and intracellular cancers. SP140 is an interferon inducible nuclear leukocyte-specific protein involved in primary biliary cirrhosis and a risk factor in chronic lymphocytic leukemia. It is also implicated in innate immune response to human immunodeficiency virus type 1 (HIV-1) by binding to the virus viral infectivity factor (Vif) protein. Both Sp110 and Sp140 contain a SAND domain, a plant homeodomain (PHD) finger, and a bromodomain (BRD).


Pssm-ID: 277016 [Multi-domain]  Cd Length: 43  Bit Score: 48.49  E-value: 1.04e-07
                          10        20
                  ....*....|....*....|....*....
gi 1191843227 484 DTCPRAFHENCHIPPAVAK-RRPWSCTFC 511
Cdd:cd15541    15 DKCPRVFHLDCHIPPIPEFpSGEWSCSLC 43
PHA03247 PHA03247
large tegument protein UL36; Provisional
 120-342 1.03e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 52.25  E-value: 1.03e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227  120 APASTAERSSVRPLLPLPACQGPPPSGPSLVPSVSEPAAPVQPSTEilPKPPSPAGLAKTPPGIIQEGRLTPVSSDSLIL 199
Cdd:PHA03247  2721 LPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGP--PAPAPPAAPAAGPPRRLTRPAVASLSESRESL 2798

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227  200 QTEDKEDTPEVPCTPSGSA--PAIKDDSPKPHDPEELQEAPRMPPNKKGKKKKRCIWATP----KRRHKKKCLPREGALP 273
Cdd:PHA03247  2799 PSPWDPADPPAAVLAPAAAlpPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPggdvRRRPPSRSPAAKPAAP 2878

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1191843227  274 DHGIQEKLQ--GVDQETQRKddstgnaevmtTAPKTKPKCARTLKPEETTDDIPEVVEEKRPQEPPSRPTR 342
Cdd:PHA03247  2879 ARPPVRRLArpAVSRSTESF-----------ALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 541-611 1.64e-06

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 46.15  E-value: 1.64e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1191843227 541 CEFLLLKAYCHPQSSFFAET--PRNIQDYGEPFKEAMWLDLVKERLTERVY-TVAWFLRDMRLIFRNHQMFYKA 611
Cdd:pfam00439   1 CLEILDKLMEHPIAAPFLEPvdPDEYPDYYSVIKKPMDLSTIKKKLENGEYkSLAEFLADVKLIFSNARTYNGP 74
PHA03247 PHA03247
large tegument protein UL36; Provisional
 114-344 4.22e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 4.22e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227  114 AAAPQEAPASTAERSSVRPLLPLPACQGP----PPSGPSLVPSVSEPAAPVQPSTEILPKPPSPAGLAKTPpgiiqegrl 189
Cdd:PHA03247  2738 APAPPAVPAGPATPGGPARPARPPTTAGPpapaPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPP--------- 2808

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227  190 TPVSSDSLILQTEDKEDTPEVPCT-PSGSAPAIKDDSPKPHDPEELQEAP-----RMPPNKKGKKKKRCIWATPKRRHKK 263
Cdd:PHA03247  2809 AAVLAPAAALPPAASPAGPLPPPTsAQPTAPPPPPGPPPPSLPLGGSVAPggdvrRRPPSRSPAAKPAAPARPPVRRLAR 2888

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227  264 KCLPREG---ALPDHGIQEKLQGVDQETQRKDDSTGNAEVMTTAPKTKPKCARTLKPEETTDDIPEV------------- 327
Cdd:PHA03247  2889 PAVSRSTesfALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPsgavpqpwlgalv 2968

                          250       260
                   ....*....|....*....|
gi 1191843227  328 ---VEEKRPQEPPSRPTRTA 344
Cdd:PHA03247  2969 pgrVAVPRFRVPQPAPSREA 2988
PHA03247 PHA03247
large tegument protein UL36; Provisional
 106-294 1.27e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 1.27e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227  106 SHRGWSRSAAAPQEAPASTAERSSVRPLLPLPACQGP-PPSGPSLVPsvsEPAAPVQP-STEILPKPPSPAGLAKTPPgi 183
Cdd:PHA03247  2863 RRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFAlPPDQPERPP---QPQAPPPPqPQPQPPPPPQPQPPPPPPP-- 2937

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227  184 IQEGRLTPVSSDSLILQTEDKEDTPEVPCTPSGSAPAIKDDSPKPHDPEELqEAPRMPPNKKGKKKKRCIWATPKRRHKK 263
Cdd:PHA03247  2938 RPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREA-PASSTPPLTGHSLSRVSSWASSLALHEE 3016

                          170       180       190
                   ....*....|....*....|....*....|.
gi 1191843227  264 KCLPREGALPDHGIQEKLQGVDQETQRKDDS 294
Cdd:PHA03247  3017 TDPPPVSLKQTLWPPDDTEDSDADSLFDSDS 3047
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 65-231 1.07e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 45.44  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227  65 ILTKLEKTFSLSFLEMlfghiNLYEYPSLMAVfksfKNVVTSHRGWSRSAAAPQEAPASTAERSsvrplLPLPACQGPPP 144
Cdd:PRK14959  342 VLTSLEPAMALELLLL-----NLAMLPRLMPV----ESLRPSGGGASAPSGSAAEGPASGGAAT-----IPTPGTQGPQG 407

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 145 SGP--SLVPSVSEPAAPVQ--------PSTEILPKPPSPAGLAKTPPGIiqeGRLTPVSSdslilqtedkedTPEVPCTP 214
Cdd:PRK14959  408 TAPaaGMTPSSAAPATPAPsaapsprvPWDDAPPAPPRSGIPPRPAPRM---PEASPVPG------------APDSVASA 472

                         170
                  ....*....|....*...
gi 1191843227 215 SGSAPAIKD-DSPKPHDP 231
Cdd:PRK14959  473 SDAPPTLGDpSDTAEHTP 490
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 110-350 2.32e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 44.30  E-value: 2.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 110 WSRSAAAPQEAPASTAERSSVRPLLP--LPACQGPPPSGPSLVPSV--SEPAAPVQPSTEilPKPPSPAGLAKTPPGIIQ 185
Cdd:PTZ00449  679 YLDAAAKSKETKTTVVLDESFESILKetLPETPGTPFTTPRPLPPKlpRDEEFPFEPIGD--PDAEQPDDIEFFTPPEEE 756

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 186 EGRLTPVSSDSLILQ-TEDKEDTPEVPC-TPSGSAPAIKDDSPKPHDPEELQEAPRMPpnkkgkkkkrciwaTPKRRHKK 263
Cdd:PTZ00449  757 RTFFHETPADTPLPDiLAEEFKEEDIHAeTGEPDEAMKRPDSPSEHEDKPPGDHPSLP--------------KKRHRLDG 822

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 264 KCLPREGALPDHGIQEKLQGVDQETQRKDDSTGNAEVMTTAPKTKPKCARTLKPEETTDDIPE-----------VVEEKR 332
Cdd:PTZ00449  823 LALSTTDLESDAGRIAKDASGKIVKLKRSKSFDDLTTVEEAEEMGAEARKIVVDDDGTEADDEdthppeekhksEVRRRR 902

                         250
                  ....*....|....*...
gi 1191843227 333 PQEPPSRPTRTANKGKER 350
Cdd:PTZ00449  903 PPKKPSKPKKPSKPKKPK 920
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 563-629 2.83e-04

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 40.37  E-value: 2.83e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1191843227 563 NIQDYGEPFKEAMWLDLVKERLTERVYT-VAWFLRDMRLIFRNHQMFY-KASDFGQIGLDLEAEFEKDL 629
Cdd:cd05500    35 NIPHYPTIIKKPMDLGTIERKLKSNVYTsVEEFTADFNLMVDNCLTFNgPEHPVSQMGKRLQAAFEKHL 103
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 89-220 4.04e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.55  E-value: 4.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227  89 EYPSL-MAVFK--SFK--NVVTSHRGWSRSAAAPQEAPASTAERSSVRPLLPLPAcqgPPPSGPSLVPSVSEPA---APV 160
Cdd:PRK14951  350 EYAALtMVLLRllAFKpaAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPA---AAPAAAASAPAAPPAAappAPV 426

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 161 QPSTEILPKPPSPAGLAKTPPGIIQEGRLTPVSSdSLILQTEDKEDTPEVPCTPSGSAPA 220
Cdd:PRK14951  427 AAPAAAAPAAAPAAAPAAVALAPAPPAQAAPETV-AIPVRVAPEPAVASAAPAPAAAPAA 485
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 73-243 5.76e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 43.16  E-value: 5.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227  73 FSLSFLEMLFGHINLYEYPSLMAVFKSFKNVVTSHRGWSRSAAA--PQEAPASTAERSSVRpllpLPACQGPPPSGPSLV 150
Cdd:PRK08691  348 FMMTLLRMLAFAPLAAASCDANAVIENTELQSPSAQTAEKETAAkkPQPRPEAETAQTPVQ----TASAAAMPSEGKTAG 423

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 151 PSVSEPAAPVQPSTEILPKPPSPAGLAKTPPGIIQEGR--LTPVSSDSLILQTEDKEDTPEVPCTPSgSAPAIKDDSPKP 228
Cdd:PRK08691  424 PVSNQENNDVPPWEDAPDEAQTAAGTAQTSAKSIQTASeaETPPENQVSKNKAADNETDAPLSEVPS-ENPIQATPNDEA 502

                         170
                  ....*....|....*.
gi 1191843227 229 HDPEEL-QEAPRMPPN 243
Cdd:PRK08691  503 VETETFaHEAPAEPFY 518
PHA03247 PHA03247
large tegument protein UL36; Provisional
 110-242 5.77e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 5.77e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227  110 WSRSAAAPQEAPASTAERSSVRPLLPLPACQGPPPSGPSLVPSVSEPAAP----VQPSTEILPKPPSPAGLAKtpPGIIQ 185
Cdd:PHA03247  2802 WDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPlggsVAPGGDVRRRPPSRSPAAK--PAAPA 2879

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227  186 EGRLTPVSSDSLILQTED---KEDTPEVPCTPSGSAPAIkdDSPKPHDPEELQEAPRMPP 242
Cdd:PHA03247  2880 RPPVRRLARPAVSRSTESfalPPDQPERPPQPQAPPPPQ--PQPQPPPPPQPQPPPPPPP 2937
PRK13729 PRK13729
conjugal transfer pilus assembly protein TraB; Provisional
 115-221 6.18e-04

conjugal transfer pilus assembly protein TraB; Provisional


Pssm-ID: 184281 [Multi-domain]  Cd Length: 475  Bit Score: 42.89  E-value: 6.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 115 AAPQEAPASTAERSSVRPLLPLPAcqgpPPSGPSLVPSVSEPAAPVQPSTEILPKPPSP--AGLAKTPPGIIQ-EGRLTP 191
Cdd:PRK13729  117 AEQVKALGANPVTATGEPVPQMPA----SPPGPEGEPQPGNTPVSFPPQGSVAVPPPTAfyPGNGVTPPPQVTyQSVPVP 192

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1191843227 192 VSSDSLILQTEDKEDTPEVPCTPSGS-APAI 221
Cdd:PRK13729  193 NRIQRKTFTYNEGKKGPSLPYIPSGSfAKAM 223
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
115-344 6.45e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.94  E-value: 6.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 115 AAPqeAPASTAERSSVRPLLPLPACQGPPPSGPSLVPSVSEPAAPVQPSTEILPKPPSPAGLAKTPPGIIQEGRLTPVSs 194
Cdd:PRK12323  372 AGP--ATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAP- 448

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 195 dslilqtedkEDTPEVPCTPSGSAPAIKDDSPKPHDPEELQEAPRMPPNKKGkkkkrciwATPKRRHKKKCLPREGALPD 274
Cdd:PRK12323  449 ----------APAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPA--------PADDDPPPWEELPPEFASPA 510

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 275 HGIQEKLQGVDQETQRKDDSTGNAevmttapktkPKCARTLKPEETTDDIPEVVEEKRPQEPPSRPTRTA 344
Cdd:PRK12323  511 PAQPDAAPAGWVAESIPDPATADP----------DDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASA 570
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 113-241 7.49e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.78  E-value: 7.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 113 SAAAPQEAPASTAerSSVRPLLPLPACQGPPPSGPSLVPSVSEPAAPVQPSTEILPKPPSPAGlakTPPGIIQEGRLTPV 192
Cdd:PRK14951  367 AAAAEAAAPAEKK--TPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVA---APAAAAPAAAPAAA 441

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1191843227 193 SSDSLILQTEDKEDTPEVPCTPSGSAPAIKDDSPKPHDPEELQEAPRMP 241
Cdd:PRK14951  442 PAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTP 490
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
134-289 7.74e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 42.46  E-value: 7.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 134 LPLPACQGPPPSGP--SLVPSVSEPAAPVQPSTEILPKP-PSPAGLAKTPPgiiqegrltpvssdslilqtedkedTPEV 210
Cdd:PRK14971  362 LTQKGDDASGGRGPkqHIKPVFTQPAAAPQPSAAAAASPsPSQSSAAAQPS-------------------------APQS 416

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1191843227 211 PCTPSGSAPAIKDDSPKPhdpeelqeAPRMPPNKKGKKKKRCIWATPKRRHKKKcLPREGALPDHGIQEKLQGVDQETQ 289
Cdd:PRK14971  417 ATQPAGTPPTVSVDPPAA--------VPVNPPSTAPQAVRPAQFKEEKKIPVSK-VSSLGPSTLRPIQEKAEQATGNIK 486
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 112-342 9.02e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 42.37  E-value: 9.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 112 RSAAAPQEAPASTAERSSVRP-LLPLPACQGPP--PSGPSLVPSVSEPAAPVQPSTEILPKPPSPAGLAKTP--PGI--- 183
Cdd:PTZ00449  595 KKPKRPRSAQRPTRPKSPKLPeLLDIPKSPKRPesPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPKPPfdPKFkek 674

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 184 -----------IQEGRLTPVSSDSliLQTEDKEDTPEVPCTPSGSAPAIkddSPK-PHDPEELQEAPRMPPNKKGKKKKR 251
Cdd:PTZ00449  675 fyddyldaaakSKETKTTVVLDES--FESILKETLPETPGTPFTTPRPL---PPKlPRDEEFPFEPIGDPDAEQPDDIEF 749

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 252 CIWATPKRRHKKKClPREGALPDhgiqeklqgvdqetqrkddstgnaeVMTTAPKTKPKCARTLKPEETTD--DIPEVVE 329
Cdd:PTZ00449  750 FTPPEEERTFFHET-PADTPLPD-------------------------ILAEEFKEEDIHAETGEPDEAMKrpDSPSEHE 803

                         250
                  ....*....|...
gi 1191843227 330 EKRPQEPPSRPTR 342
Cdd:PTZ00449  804 DKPPGDHPSLPKK 816
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
108-241 1.01e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.17  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 108 RGWSRSAAAPQEAPASTAERSSVRPLLPLPACQGPPPSGPSLVPSVSEPAAPVQPSTEILPK-PPSPAGLAKTPPGIIQE 186
Cdd:PRK12323  437 RQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPwEELPPEFASPAPAQPDA 516

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1191843227 187 GRLTPVSSDSLILQTEDKEDTPEVPCTPSGSAPAikddsPKPHDPEELQEAPRMP 241
Cdd:PRK12323  517 APAGWVAESIPDPATADPDDAFETLAPAPAAAPA-----PRAAAATEPVVAPRPP 566
KLF9_13_N-like cd21975
Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like ...
 111-241 1.41e-03

Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF9, KLF13, KLF14, KLF16, and similar proteins.


Pssm-ID: 409240 [Multi-domain]  Cd Length: 163  Bit Score: 40.06  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 111 SRSAAAPQEAPASTAERSsvrpllplpacqgPPPSGPSLVPSVSEPAAPVQPSTEILPKPPSPAGLAKTPPGIIQEGRLT 190
Cdd:cd21975    11 SISAGAVVHGVRPDPEGA-------------GLAAGLDVRATREVAKGPGPPGPAWKPDGADSPGLVTAAPHLLAANVLA 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1191843227 191 PVSSDSLILQTEDKEDTPEVPCTPSGSAPAikddSPKPHDPEELQEAPRMP 241
Cdd:cd21975    78 PLRGPSVEGSSLESGDADMGSDSDVAPASG----AAASTSPESSSDAASSP 124
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 541-627 1.53e-03

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 38.12  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 541 CEFLLLKAYCHPQSSFFAE--TPRNIQDYGEPFKEAMWLDLVKERLTERVY-TVAWFLRDMRLIFRNHQMFYK-ASDFGQ 616
Cdd:cd05503     5 CETILDEMEAHEDAWPFLEpvNTKLVPGYRKIIKKPMDFSTIREKLESGQYkTLEEFAEDVRLVFDNCETFNEdDSEVGR 84

                          90
                  ....*....|.
gi 1191843227 617 IGLDLEAEFEK 627
Cdd:cd05503    85 AGHNMRKFFEK 95
PHA03247 PHA03247
large tegument protein UL36; Provisional
 105-228 1.72e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 1.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227  105 TSHRGWSRSAAAPQEAPASTAERSSVRPLLPLPAcqgPPPSGPslvpsvsEPAAPVQPSTEILPKPPSPAGLAKTPPGII 184
Cdd:PHA03247  2667 ARRLGRAAQASSPPQRPRRRAARPTVGSLTSLAD---PPPPPP-------TPEPAPHALVSATPLPPGPAAARQASPALP 2736

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1191843227  185 QEGRLTPVSSDSLILQTEDKEDTPEVPCTPSGSAPAIKDDSPKP 228
Cdd:PHA03247  2737 AAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPP 2780
PHA03247 PHA03247
large tegument protein UL36; Provisional
 112-341 1.78e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 1.78e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227  112 RSAAAPQEAPASTAERSSVRPLLPLPACQGP-PPSGPSLVPSVSEPAAPVQPSTEILPKPPSPAGLAKTPPGIIQEGRLT 190
Cdd:PHA03247  2653 RDDPAPGRVSRPRRARRLGRAAQASSPPQRPrRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQAS 2732

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227  191 PVSSDSLILQTedkedTPEVPCTPSGSAPAIKDDSPK-PHDPeelqEAPRMPPNKKGKKKKRCIWATPKRRHKKKCLPRE 269
Cdd:PHA03247  2733 PALPAAPAPPA-----VPAGPATPGGPARPARPPTTAgPPAP----APPAAPAAGPPRRLTRPAVASLSESRESLPSPWD 2803

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1191843227  270 GALPDHGIQEKLQGVDQETQRKDDSTGNAEVMTTAP-KTKPKCARTLKPEETTDDIPEVVEEKRPQEPPSRPT 341
Cdd:PHA03247  2804 PADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPpPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPA 2876
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 115-242 1.94e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.29  E-value: 1.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 115 AAPQEAPASTAERSsvrplLPLPACQGPPPSGPSLVPSVSE-PAAPVQP--STEILPKPPSPAGLAKTPPGIIQEGRLTP 191
Cdd:pfam03154 426 PPPAQPPVLTQSQS-----LPPPAASHPPTSGLHQVPSQSPfPQHPFVPggPPPITPPSGPPTSTSSAMPGIQPPSSASV 500

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1191843227 192 VSSDSlilqtedkedtpeVPCTPSGSAPAIK------DDSPKPHDPEELQEAPRMPP 242
Cdd:pfam03154 501 SSSGP-------------VPAAVSCPLPPVQikeealDEAEEPESPPPPPRSPSPEP 544
PHA03378 PHA03378
EBNA-3B; Provisional
 110-242 2.71e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.82  E-value: 2.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 110 WSRSAAAPqeAPASTAERSSVRPLLPLPACQGPPPSGPSLVPSVSEPAAPVQ-PSTEILPKPPSPAGLAKTPPGIIQEGR 188
Cdd:PHA03378  666 WTQIGHIP--YQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQrPAAATGRARPPAAAPGRARPPAAAPGR 743

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1191843227 189 LTPVSSDSLILQTEDKEDTPEVPCTPSGSAPAikdDSPKPHDPEELQEAPRMPP 242
Cdd:PHA03378  744 ARPPAAAPGRARPPAAAPGRARPPAAAPGAPT---PQPPPQAPPAPQQRPRGAP 794
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 101-242 2.76e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.91  E-value: 2.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 101 KNVVTSHRGWSRSAAAPQEAPA---STAERSSVRPLLPLPACQGPPPSGPSLVPS--VSEPAAPVQPSTEILPKPPSPag 175
Cdd:pfam03154 135 KDIDQDNRSTSPSIPSPQDNESdsdSSAQQQILQTQPPVLQAQSGAASPPSPPPPgtTQAATAGPTPSAPSVPPQGSP-- 212

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1191843227 176 lAKTPPGIIQEGRLTPVssdSLILQT----EDKEDTPEVPCTPSGSAPAIKDDSPKPHDPEELQEapRMPP 242
Cdd:pfam03154 213 -ATSQPPNQTQSTAAPH---TLIQQTptlhPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHG--QMPP 277
PHA03247 PHA03247
large tegument protein UL36; Provisional
 116-341 2.89e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 2.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227  116 APQEAPASTAERSsvrplLPLPACqGPPPSGPSLVPSVSEPAAPVQPSTeilpkPPSPAGLAKTPPGIIQEGRLTPvssd 195
Cdd:PHA03247  2555 LPPAAPPAAPDRS-----VPPPRP-APRPSEPAVTSRARRPDAPPQSAR-----PRAPVDDRGDPRGPAPPSPLPP---- 2619

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227  196 slilqtedkEDTPEVPCTPSGSAPAIKDD------SPKPHDPEELQEAPRMPPNKKGKKKKRCIWAT-PKRRhkkkclPR 268
Cdd:PHA03247  2620 ---------DTHAPDPPPPSPSPAANEPDphppptVPPPERPRDDPAPGRVSRPRRARRLGRAAQASsPPQR------PR 2684

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1191843227  269 EGALPDHGIQEKLQGVDQETQRKDDSTGNAEVMTTAPKTKPKCARTLKPEETTDDIPEVVEEK-----RPQEPPSRPT 341
Cdd:PHA03247  2685 RRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGpatpgGPARPARPPT 2762
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 113-350 3.36e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 3.36e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227  113 SAAAPQEAPASTAERSSVRPLLPLPACQGPPPSGPSLVPSVSEPAAPVQPSTEILPKPPSPAGLAKTP-PGIIQEGRLTP 191
Cdd:PHA03307   155 AGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPaPGRSAADDAGA 234

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227  192 VSSDSLILQTEDKEDTPEVPCTPSGSAPAIKDDSPKPHDPEELQEAPRMPPNKKGKKKKRCIWATPKRRHKKKCLPRega 271
Cdd:PHA03307   235 SSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSS--- 311

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1191843227  272 lpdHGIQEKLQGVDQETQRKDDSTGNAEvMTTAPKTKPKCARTLKPEETTDDIPEVVEEKRPQEPPSRPTRTANKGKER 350
Cdd:PHA03307   312 ---PRASSSSSSSRESSSSSTSSSSESS-RGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPT 386
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 113-223 3.62e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 40.56  E-value: 3.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 113 SAAAPQEAPASTAERSSVRPllplpacqGPPPSGPSLVPsVSEPAAPVQPSTEILPKPPSPAGLAKTPPGIIQEGrlTPV 192
Cdd:PRK14950  362 PVPAPQPAKPTAAAPSPVRP--------TPAPSTRPKAA-AAANIPPKEPVRETATPPPVPPRPVAPPVPHTPES--APK 430

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1191843227 193 SSDSLILQTEDKEDTPEVPcTPSGSAPAIKD 223
Cdd:PRK14950  431 LTRAAIPVDEKPKYTPPAP-PKEEEKALIAD 460
PHD pfam00628
PHD-finger; PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar ...
 484-514 3.83e-03

PHD-finger; PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar manner to that of the RING and FYVE domains. Several PHD fingers have been identified as binding modules of methylated histone H3.


Pssm-ID: 425785 [Multi-domain]  Cd Length: 51  Bit Score: 35.93  E-value: 3.83e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1191843227 484 DTCPRAFHENCHIPPAVAKRRP---WSCTFCRMR 514
Cdd:pfam00628  18 DGCDDWFHLACLGPPLDPAEIPsgeWLCPECKPK 51
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 111-231 3.97e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 40.18  E-value: 3.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 111 SRSAAAPQEAPASTAERSSVRPLLPLPACQGPPPSGPSLVPSVSEPAAPVQPSTEILPKPPSPAGLAK--TPPGIIQEGR 188
Cdd:PRK14950  375 APSPVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPHTPESAPKLTRAAIPVDEKPkyTPPAPPKEEE 454

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1191843227 189 LTPVSSDSLILQTEdkedtpevpctpsGSAPAIKDDSPkPHDP 231
Cdd:PRK14950  455 KALIADGDVLEQLE-------------AIWKQILRDVP-PRSP 483
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 108-239 4.32e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.35  E-value: 4.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 108 RGWSRSAAAPQEAPASTAERSSVRPLLPLPACQ----GPPPSGPSLVPSVSEPAAPVQPSteiLPKPPSPAGLAKTPPGI 183
Cdd:PRK07764  402 AAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPApapaPAPPSPAGNAPAGGAPSPPPAAA---PSAQPAPAPAAAPEPTA 478

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1191843227 184 IQEGRLTPVSSDSlilqtedkeDTPEVPCTPSGSAPAIKDDSPKPHDPEELQEAPR 239
Cdd:PRK07764  479 APAPAPPAAPAPA---------AAPAAPAAPAAPAGADDAATLRERWPEILAAVPK 525
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 101-231 4.97e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.15  E-value: 4.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227  101 KNVVTSHRGWSRSAAAPQEAPASTAERSSvrPLLPLPACQGPPPSGPSLVPSVSEPAAPVQPSTEILPKPPSPAGLAKTP 180
Cdd:PHA03307    84 SRSTPTWSLSTLAPASPAREGSPTPPGPS--SPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAA 161

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1191843227  181 PGIIQEGRLTPVSSDSLILQTEDKEDTPEVPCTPSGSAPAIKDDSPKPHDP 231
Cdd:PHA03307   162 VASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSP 212
DUF3729 pfam12526
Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins ...
 108-182 6.37e-03

Protein of unknown function (DUF3729); This family of proteins is found in viruses. Proteins in this family are typically between 145 and 1707 amino acids in length. The family is found in association with pfam01443, pfam01661, pfam05417, pfam01660, pfam00978. There is a single completely conserved residue L that may be functionally important.


Pssm-ID: 372164 [Multi-domain]  Cd Length: 115  Bit Score: 36.98  E-value: 6.37e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1191843227 108 RGWSRSAAAPQEAPASTAERSSVRPL-LPLPACQGPPPSGPSLV--PSVSEPAAPVQPSTEILPKPPSPAGLAKTPPG 182
Cdd:pfam12526  18 RTWSTSGFSSCFSPPESAHPDPPPPVgDPRPPVVDTPPPVSAVWvlPPPSEPAAPEPDLVPPVTGPAGPPSPLAPPAP 95
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
112-220 9.31e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 39.06  E-value: 9.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191843227 112 RSAAAPQEAPASTAERSSVRPLLPLPA-CQGPPPSGPSLVPSVSEPAAPVQPSTEILPKPPSPAGLAK--TPPGIIQEGR 188
Cdd:PRK07003  423 AEAPPAAPAPPATADRGDDAADGDAPVpAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFepAPRAAAPSAA 502

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1191843227 189 LTPVSSDSLILQTEDKEDTPEVPCTPSGSAPA 220
Cdd:PRK07003  503 TPAAVPDARAPAAASREDAPAAAAPPAPEARP 534
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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