NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1207130237|ref|XP_021323057|]
View 

transforming growth factor-beta receptor-associated protein 1-like [Danio rerio]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Vps39_2 super family cl11034
Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein ...
 725-832 2.18e-20

Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. This domain is involved in localization and in mediating the interactions of Vps39 with Vps11.


The actual alignment was detected with superfamily member pfam10367:

Pssm-ID: 402126  Cd Length: 109  Bit Score: 86.92  E-value: 2.18e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207130237 725 VDLLNKNPESFDLSSVLMVLPESWSLKVVLRFLCESLRGTVHDKRMRGLEMSLAKVETLRHRHALMAATHEKIQVDRGCV 804
Cdd:pfam10367   1 LDLLNKHAERIDPAQVLQLLPDEIPLQDLSSFLERALRNSSEAKREAQVVKNLSKAENLQVEEELLKLRSRKVRVTEESV 80

                          90       100
                  ....*....|....*....|....*...
gi 1207130237 805 CHSCQKRLTGAEFLRRPTGELTHITCHN 832
Cdd:pfam10367  81 CAVCHKRLGESVFVVYPNGVVVHYGCFR 108
Vps39_1 super family cl11033
Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein ...
 440-543 1.62e-17

Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. The precise function of this domain has not been characterized.


The actual alignment was detected with superfamily member pfam10366:

Pssm-ID: 371008  Cd Length: 108  Bit Score: 78.82  E-value: 1.62e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207130237 440 IDSALFKLYLEQGENEkLDQLVSTQNNCNLQMCVADLEQHKRFFTLGLLYQSQGQHFNAIQTWIKIVEDESEDPSNTSVF 519
Cdd:pfam10366   1 IDTTLLKCYLYTNPSL-VGPLLRIENACDLEDVEEWLKKHKKYSELIDLYYGKGLHREALQLLTELADETTGDETDSTLK 79

                          90       100
                  ....*....|....*....|....*....
gi 1207130237 520 QH---IVKTLSNL--EHKQIIWKFVDWVL 543
Cdd:pfam10366  80 GPketIIQYLQKLgpSDLDLILEYSDWVL 108
CLH super family cl46917
Clathrin heavy chain repeat homology;
581-687 1.01e-03

Clathrin heavy chain repeat homology;


The actual alignment was detected with superfamily member smart00299:

Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 40.34  E-value: 1.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207130237  581 LTLYLEYLVNEShSKEEKHHTMLItsyvkrilrSLADDHNNESSTEEMRHKlqqllwqSSFYNADQIYDqIASSSLHVEQ 660
Cdd:smart00299  26 LIPYLESALKLN-SENPALQTKLI---------ELYAKYDPQKEIERLDNK-------SNHYDIEKVGK-LCEKAKLYEE 87

                           90       100
                   ....*....|....*....|....*...
gi 1207130237  661 AISL-GKNGKHKKALQVLVNEEKDQQAA 687
Cdd:smart00299  88 AVELyKKDGNFKDAIVTLIEHLGNYEKA 115
 
Name Accession Description Interval E-value
Vps39_2 pfam10367
Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein ...
 725-832 2.18e-20

Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. This domain is involved in localization and in mediating the interactions of Vps39 with Vps11.


Pssm-ID: 402126  Cd Length: 109  Bit Score: 86.92  E-value: 2.18e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207130237 725 VDLLNKNPESFDLSSVLMVLPESWSLKVVLRFLCESLRGTVHDKRMRGLEMSLAKVETLRHRHALMAATHEKIQVDRGCV 804
Cdd:pfam10367   1 LDLLNKHAERIDPAQVLQLLPDEIPLQDLSSFLERALRNSSEAKREAQVVKNLSKAENLQVEEELLKLRSRKVRVTEESV 80

                          90       100
                  ....*....|....*....|....*...
gi 1207130237 805 CHSCQKRLTGAEFLRRPTGELTHITCHN 832
Cdd:pfam10367  81 CAVCHKRLGESVFVVYPNGVVVHYGCFR 108
Vps39_1 pfam10366
Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein ...
 440-543 1.62e-17

Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. The precise function of this domain has not been characterized.


Pssm-ID: 371008  Cd Length: 108  Bit Score: 78.82  E-value: 1.62e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207130237 440 IDSALFKLYLEQGENEkLDQLVSTQNNCNLQMCVADLEQHKRFFTLGLLYQSQGQHFNAIQTWIKIVEDESEDPSNTSVF 519
Cdd:pfam10366   1 IDTTLLKCYLYTNPSL-VGPLLRIENACDLEDVEEWLKKHKKYSELIDLYYGKGLHREALQLLTELADETTGDETDSTLK 79

                          90       100
                  ....*....|....*....|....*....
gi 1207130237 520 QH---IVKTLSNL--EHKQIIWKFVDWVL 543
Cdd:pfam10366  80 GPketIIQYLQKLgpSDLDLILEYSDWVL 108
CLH smart00299
Clathrin heavy chain repeat homology;
581-687 1.01e-03

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 40.34  E-value: 1.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207130237  581 LTLYLEYLVNEShSKEEKHHTMLItsyvkrilrSLADDHNNESSTEEMRHKlqqllwqSSFYNADQIYDqIASSSLHVEQ 660
Cdd:smart00299  26 LIPYLESALKLN-SENPALQTKLI---------ELYAKYDPQKEIERLDNK-------SNHYDIEKVGK-LCEKAKLYEE 87

                           90       100
                   ....*....|....*....|....*...
gi 1207130237  661 AISL-GKNGKHKKALQVLVNEEKDQQAA 687
Cdd:smart00299  88 AVELyKKDGNFKDAIVTLIEHLGNYEKA 115
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 581-690 8.28e-03

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 37.62  E-value: 8.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207130237 581 LTLYLEYLVNESHSKEEKHHTMLITSYVKrilrsladdhnnesstEEMRHKLQQLLWQSSFYNADQIYDQIASSSLHVEQ 660
Cdd:pfam00637  26 LISYLESALKEDSRENPALQTALIELYAK----------------YDDPEELEEFLKKNNNYDLEKVAKLCEKADLYEEA 89

                          90       100       110
                  ....*....|....*....|....*....|
gi 1207130237 661 AISLGKNGKHKKALQVLVNEEKDQQAAECY 690
Cdd:pfam00637  90 VILYKKIGNWKEAISLLKKLGDYKDAIEYA 119
 
Name Accession Description Interval E-value
Vps39_2 pfam10367
Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein ...
 725-832 2.18e-20

Vacuolar sorting protein 39 domain 2; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. This domain is involved in localization and in mediating the interactions of Vps39 with Vps11.


Pssm-ID: 402126  Cd Length: 109  Bit Score: 86.92  E-value: 2.18e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207130237 725 VDLLNKNPESFDLSSVLMVLPESWSLKVVLRFLCESLRGTVHDKRMRGLEMSLAKVETLRHRHALMAATHEKIQVDRGCV 804
Cdd:pfam10367   1 LDLLNKHAERIDPAQVLQLLPDEIPLQDLSSFLERALRNSSEAKREAQVVKNLSKAENLQVEEELLKLRSRKVRVTEESV 80

                          90       100
                  ....*....|....*....|....*...
gi 1207130237 805 CHSCQKRLTGAEFLRRPTGELTHITCHN 832
Cdd:pfam10367  81 CAVCHKRLGESVFVVYPNGVVVHYGCFR 108
Vps39_1 pfam10366
Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein ...
 440-543 1.62e-17

Vacuolar sorting protein 39 domain 1; This domain is found on the vacuolar sorting protein Vps39 which is a component of the C-Vps complex. Vps39 is thought to be required for the fusion of endosomes and other types of transport intermediates with the vacuole. In Saccharomyces cerevisiae, Vps39 has been shown to stimulate nucleotide exchange. The precise function of this domain has not been characterized.


Pssm-ID: 371008  Cd Length: 108  Bit Score: 78.82  E-value: 1.62e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207130237 440 IDSALFKLYLEQGENEkLDQLVSTQNNCNLQMCVADLEQHKRFFTLGLLYQSQGQHFNAIQTWIKIVEDESEDPSNTSVF 519
Cdd:pfam10366   1 IDTTLLKCYLYTNPSL-VGPLLRIENACDLEDVEEWLKKHKKYSELIDLYYGKGLHREALQLLTELADETTGDETDSTLK 79

                          90       100
                  ....*....|....*....|....*....
gi 1207130237 520 QH---IVKTLSNL--EHKQIIWKFVDWVL 543
Cdd:pfam10366  80 GPketIIQYLQKLgpSDLDLILEYSDWVL 108
CLH smart00299
Clathrin heavy chain repeat homology;
581-687 1.01e-03

Clathrin heavy chain repeat homology;


Pssm-ID: 128594 [Multi-domain]  Cd Length: 140  Bit Score: 40.34  E-value: 1.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207130237  581 LTLYLEYLVNEShSKEEKHHTMLItsyvkrilrSLADDHNNESSTEEMRHKlqqllwqSSFYNADQIYDqIASSSLHVEQ 660
Cdd:smart00299  26 LIPYLESALKLN-SENPALQTKLI---------ELYAKYDPQKEIERLDNK-------SNHYDIEKVGK-LCEKAKLYEE 87

                           90       100
                   ....*....|....*....|....*...
gi 1207130237  661 AISL-GKNGKHKKALQVLVNEEKDQQAA 687
Cdd:smart00299  88 AVELyKKDGNFKDAIVTLIEHLGNYEKA 115
Clathrin pfam00637
Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are ...
 581-690 8.28e-03

Region in Clathrin and VPS; Each region is about 140 amino acids long. The regions are composed of multiple alpha helical repeats. They occur in the arm region of the Clathrin heavy chain.


Pssm-ID: 459884 [Multi-domain]  Cd Length: 142  Bit Score: 37.62  E-value: 8.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207130237 581 LTLYLEYLVNESHSKEEKHHTMLITSYVKrilrsladdhnnesstEEMRHKLQQLLWQSSFYNADQIYDQIASSSLHVEQ 660
Cdd:pfam00637  26 LISYLESALKEDSRENPALQTALIELYAK----------------YDDPEELEEFLKKNNNYDLEKVAKLCEKADLYEEA 89

                          90       100       110
                  ....*....|....*....|....*....|
gi 1207130237 661 AISLGKNGKHKKALQVLVNEEKDQQAAECY 690
Cdd:pfam00637  90 VILYKKIGNWKEAISLLKKLGDYKDAIEYA 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH