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Conserved domains on  [gi|1367159376|ref|XP_024203833|]
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two pore calcium channel protein 1 isoform X1 [Pan troglodytes]

Protein Classification

ion transporter (domain architecture ID 11997982)

ion transporter such as a voltage-gated cation channel, which enables the selective translocation of cations such as sodium, calcium, or potassium, across cell membranes

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
512-763 6.66e-27

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 110.05  E-value: 6.66e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1367159376 512 SKAFQYFMYLVVAVNGVWILVETFMLKGgNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPV-EYLSSGWNLFDFSVTVFA 590
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFQPE-EPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKkRYFRSPWNILDFVVVLPS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1367159376 591 FLGLLALalNMEPFYFIVVLRPLQLLRLFKLKER---YRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGivfp 667
Cdd:pfam00520  80 LISLVLS--SVGSLSGLRVLRLLRLLRLLRLIRRlegLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG---- 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1367159376 668 nccntstvaDAYRWRNHTVGNrtvveegyyylNNFDNILNSFVTLFELTVVNNWYIIMEGVT-SQTSHWSRLYFMTFYIV 746
Cdd:pfam00520 154 ---------KLKTWENPDNGR-----------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIdGKGEFWAYIYFVSFIIL 213
                         250
                  ....*....|....*...
gi 1367159376 747 TMVVMT-IIVAFILEAFV 763
Cdd:pfam00520 214 GGFLLLnLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
214-402 2.87e-17

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 81.93  E-value: 2.87e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1367159376 214 TLELFALMVVVFELCMKLRWLGL-HTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDC-RYCGGVR 291
Cdd:pfam00520  37 ILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSLISLVLSSVGSLSGLRVLRLLRLLRLLRLiRRLEGLR 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1367159376 292 RNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLF--------SPNPSDPYFSTLENSIVSLFVLLTTANFPDVMMPSYS 363
Cdd:pfam00520 117 TLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFggklktweNPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTID 196
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1367159376 364 R--NPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRK 402
Cdd:pfam00520 197 GkgEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
512-763 6.66e-27

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 110.05  E-value: 6.66e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1367159376 512 SKAFQYFMYLVVAVNGVWILVETFMLKGgNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPV-EYLSSGWNLFDFSVTVFA 590
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFQPE-EPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKkRYFRSPWNILDFVVVLPS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1367159376 591 FLGLLALalNMEPFYFIVVLRPLQLLRLFKLKER---YRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGivfp 667
Cdd:pfam00520  80 LISLVLS--SVGSLSGLRVLRLLRLLRLLRLIRRlegLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG---- 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1367159376 668 nccntstvaDAYRWRNHTVGNrtvveegyyylNNFDNILNSFVTLFELTVVNNWYIIMEGVT-SQTSHWSRLYFMTFYIV 746
Cdd:pfam00520 154 ---------KLKTWENPDNGR-----------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIdGKGEFWAYIYFVSFIIL 213
                         250
                  ....*....|....*...
gi 1367159376 747 TMVVMT-IIVAFILEAFV 763
Cdd:pfam00520 214 GGFLLLnLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
214-402 2.87e-17

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 81.93  E-value: 2.87e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1367159376 214 TLELFALMVVVFELCMKLRWLGL-HTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDC-RYCGGVR 291
Cdd:pfam00520  37 ILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSLISLVLSSVGSLSGLRVLRLLRLLRLLRLiRRLEGLR 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1367159376 292 RNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLF--------SPNPSDPYFSTLENSIVSLFVLLTTANFPDVMMPSYS 363
Cdd:pfam00520 117 TLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFggklktweNPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTID 196
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1367159376 364 R--NPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRK 402
Cdd:pfam00520 197 GkgEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
512-763 6.66e-27

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 110.05  E-value: 6.66e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1367159376 512 SKAFQYFMYLVVAVNGVWILVETFMLKGgNFFSKHVPWSYLVFLTIYGVELFLKVAGLGPV-EYLSSGWNLFDFSVTVFA 590
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETYFQPE-EPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKkRYFRSPWNILDFVVVLPS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1367159376 591 FLGLLALalNMEPFYFIVVLRPLQLLRLFKLKER---YRNVLDTMFELLPRMASLGLTLLIFYYSFAIVGMEFFCGivfp 667
Cdd:pfam00520  80 LISLVLS--SVGSLSGLRVLRLLRLLRLLRLIRRlegLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG---- 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1367159376 668 nccntstvaDAYRWRNHTVGNrtvveegyyylNNFDNILNSFVTLFELTVVNNWYIIMEGVT-SQTSHWSRLYFMTFYIV 746
Cdd:pfam00520 154 ---------KLKTWENPDNGR-----------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIdGKGEFWAYIYFVSFIIL 213
                         250
                  ....*....|....*...
gi 1367159376 747 TMVVMT-IIVAFILEAFV 763
Cdd:pfam00520 214 GGFLLLnLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
214-402 2.87e-17

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 395416 [Multi-domain]  Cd Length: 238  Bit Score: 81.93  E-value: 2.87e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1367159376 214 TLELFALMVVVFELCMKLRWLGL-HTFIRHKRTMVKTSVLVVQFVEAIVVLVRQMSHVRVTRALRCIFLVDC-RYCGGVR 291
Cdd:pfam00520  37 ILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSLISLVLSSVGSLSGLRVLRLLRLLRLLRLiRRLEGLR 116
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1367159376 292 RNLRQIFQSLPPFMDILLLLLFFMIIFAILGFYLF--------SPNPSDPYFSTLENSIVSLFVLLTTANFPDVMMPSYS 363
Cdd:pfam00520 117 TLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFggklktweNPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTID 196
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1367159376 364 R--NPWSCVFFIVYLSIELYFIMNLLLAVVFDTFNDIEKRK 402
Cdd:pfam00520 197 GkgEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.19
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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