NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2468687271|ref|XP_024212587|]
View 

sodium-dependent phosphate transport protein 2A isoform X4 [Pan troglodytes]

Protein Classification

sodium-dependent phosphate transport protein 2( domain architecture ID 11490082)

sodium-dependent phosphate transport protein 2 may be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
2a58 TIGR01013
Phosphate:Na+ Symporter (PNaS) Family; [Transport and binding proteins, Cations and iron ...
108-310 5.71e-75

Phosphate:Na+ Symporter (PNaS) Family; [Transport and binding proteins, Cations and iron carrying compounds]


:

Pssm-ID: 162157 [Multi-domain]  Cd Length: 456  Bit Score: 238.22  E-value: 5.71e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468687271 108 LTFLYLFVCSLDMLSSAFQLAGGKVAGDIFKDNAILSNPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLEVSSAIPI 187
Cdd:TIGR01013   1 LVLLFVFVCSLAVLSAAFILLGAKVGGAIFADILITDNPWASPLLGFLGTVLLQSSSTSRSIVVGMVSAGLLLVLLAIPL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468687271 188 IMGSNIGTSVTNTIVALMQAGDRTDFRRAFAGATVHDCFNWLSVLVLLPLEAATGYLHHITRLVVASFNIHGGRDAPDLL 267
Cdd:TIGR01013  81 IMGANIGSSVTNAIVAIMQSGDRAWFRRAFIGATVADIFNSSLALVLLPLELTTGGIESVTLLVVLVFGANGGGDAPDLL 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 2468687271 268 KIITEPFTKLIIQLDESVITSIAtgdeSLRNHSLIRIWCHPDS 310
Cdd:TIGR01013 161 NSLTAPATALIVQLDNLIIRLIG----SLLILPLIDILASTLS 199
 
Name Accession Description Interval E-value
2a58 TIGR01013
Phosphate:Na+ Symporter (PNaS) Family; [Transport and binding proteins, Cations and iron ...
108-310 5.71e-75

Phosphate:Na+ Symporter (PNaS) Family; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 162157 [Multi-domain]  Cd Length: 456  Bit Score: 238.22  E-value: 5.71e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468687271 108 LTFLYLFVCSLDMLSSAFQLAGGKVAGDIFKDNAILSNPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLEVSSAIPI 187
Cdd:TIGR01013   1 LVLLFVFVCSLAVLSAAFILLGAKVGGAIFADILITDNPWASPLLGFLGTVLLQSSSTSRSIVVGMVSAGLLLVLLAIPL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468687271 188 IMGSNIGTSVTNTIVALMQAGDRTDFRRAFAGATVHDCFNWLSVLVLLPLEAATGYLHHITRLVVASFNIHGGRDAPDLL 267
Cdd:TIGR01013  81 IMGANIGSSVTNAIVAIMQSGDRAWFRRAFIGATVADIFNSSLALVLLPLELTTGGIESVTLLVVLVFGANGGGDAPDLL 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 2468687271 268 KIITEPFTKLIIQLDESVITSIAtgdeSLRNHSLIRIWCHPDS 310
Cdd:TIGR01013 161 NSLTAPATALIVQLDNLIIRLIG----SLLILPLIDILASTLS 199
Na_Pi_cotrans pfam02690
Na+/Pi-cotransporter; This is a family of mainly mammalian type II renal Na+/Pi-cotransporters ...
113-204 2.86e-17

Na+/Pi-cotransporter; This is a family of mainly mammalian type II renal Na+/Pi-cotransporters with other related sequences from lower eukaryotes and bacteria some of which are also Na+/Pi-cotransporters. In the kidney the type II renal Na+/Pi-cotransporters protein allows re-absorption of filtered Pi in the proximal tubule.


Pssm-ID: 426928 [Multi-domain]  Cd Length: 137  Bit Score: 77.06  E-value: 2.86e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468687271 113 LFVCSLDMLSSAFQlaggKVAGDIFKD--NAILSNPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLEVSSAIPIIMG 190
Cdd:pfam02690   1 LFLFGMKLMSDGLQ----KLAGGRLRRilEKLTSNPLKGFLVGLLVTALLQSSSATTVMVVGFVNAGLLTLAQAIGVIMG 76
                          90
                  ....*....|....
gi 2468687271 191 SNIGTSVTNTIVAL 204
Cdd:pfam02690  77 ANIGTTVTAQLIAF 90
NptA COG1283
Na+/phosphate symporter [Inorganic ion transport and metabolism];
106-238 3.16e-14

Na+/phosphate symporter [Inorganic ion transport and metabolism];


Pssm-ID: 224202 [Multi-domain]  Cd Length: 533  Bit Score: 73.44  E-value: 3.16e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468687271 106 LMLTFLYLFVCSLDMLSSAFQLAGGKVAGDIFkdNAILSNPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLEVSSAI 185
Cdd:COG1283     9 NLLGAVALLLFGIKMVGDGVQRAAGDRLRKIL--ARFTSNPILGVLAGIVATALLQSSTATTVLTIGFVAAGLLSLKQAI 86
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2468687271 186 PIIMGSNIGTSVTNTIVALmqaGDRTDFRRAFAGATVHDCFNWLSVLVLLPLE 238
Cdd:COG1283    87 GVILGANIGTTVTAWIVAL---DLSWLSPPLLAIGAILFFFGKSSKLRQLGRV 136
Na_Pi_symport NF037997
Na/Pi symporter; Proteins of this family belong to the Phosphate:Na+ Symporter (PNaS) ...
110-204 6.38e-08

Na/Pi symporter; Proteins of this family belong to the Phosphate:Na+ Symporter (PNaS) superfamily.


Pssm-ID: 411591 [Multi-domain]  Cd Length: 294  Bit Score: 52.99  E-value: 6.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468687271 110 FLYLFVCSLDMLSSA-FQLAGGKVAGDIFKdnaILSNPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLEVSSAIPII 188
Cdd:NF037997    4 YIAIFLLGMTVLRSGlFNLSGHKLKTWLLK---FTDTPLKGFLTGTVITAILQSSSAVMVLTVGLVSAGILTFRQSIGII 80
                          90
                  ....*....|....*.
gi 2468687271 189 MGSNIGTSVTNTIVAL 204
Cdd:NF037997   81 LGTNIGTTFTTEFITF 96
Na_Pi_symport NF037997
Na/Pi symporter; Proteins of this family belong to the Phosphate:Na+ Symporter (PNaS) ...
145-237 6.68e-06

Na/Pi symporter; Proteins of this family belong to the Phosphate:Na+ Symporter (PNaS) superfamily.


Pssm-ID: 411591 [Multi-domain]  Cd Length: 294  Bit Score: 46.82  E-value: 6.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468687271 145 NPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLEVSSAIPIIMGSNIGTSVTNTIVALmqAGDRTDFRRAFAgatvHD 224
Cdd:NF037997  163 SLLLALLIGTVLTAIIQSSSATTGITMSFLNEGILTLPAGIAIMLGANIGTCITALLASI--GSGKEAKLTAYA----HI 236
                          90
                  ....*....|...
gi 2468687271 225 CFNWLSVLVLLPL 237
Cdd:NF037997  237 WLNVLGVLLFLPF 249
 
Name Accession Description Interval E-value
2a58 TIGR01013
Phosphate:Na+ Symporter (PNaS) Family; [Transport and binding proteins, Cations and iron ...
108-310 5.71e-75

Phosphate:Na+ Symporter (PNaS) Family; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 162157 [Multi-domain]  Cd Length: 456  Bit Score: 238.22  E-value: 5.71e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468687271 108 LTFLYLFVCSLDMLSSAFQLAGGKVAGDIFKDNAILSNPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLEVSSAIPI 187
Cdd:TIGR01013   1 LVLLFVFVCSLAVLSAAFILLGAKVGGAIFADILITDNPWASPLLGFLGTVLLQSSSTSRSIVVGMVSAGLLLVLLAIPL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468687271 188 IMGSNIGTSVTNTIVALMQAGDRTDFRRAFAGATVHDCFNWLSVLVLLPLEAATGYLHHITRLVVASFNIHGGRDAPDLL 267
Cdd:TIGR01013  81 IMGANIGSSVTNAIVAIMQSGDRAWFRRAFIGATVADIFNSSLALVLLPLELTTGGIESVTLLVVLVFGANGGGDAPDLL 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 2468687271 268 KIITEPFTKLIIQLDESVITSIAtgdeSLRNHSLIRIWCHPDS 310
Cdd:TIGR01013 161 NSLTAPATALIVQLDNLIIRLIG----SLLILPLIDILASTLS 199
Na_Pi_cotrans pfam02690
Na+/Pi-cotransporter; This is a family of mainly mammalian type II renal Na+/Pi-cotransporters ...
113-204 2.86e-17

Na+/Pi-cotransporter; This is a family of mainly mammalian type II renal Na+/Pi-cotransporters with other related sequences from lower eukaryotes and bacteria some of which are also Na+/Pi-cotransporters. In the kidney the type II renal Na+/Pi-cotransporters protein allows re-absorption of filtered Pi in the proximal tubule.


Pssm-ID: 426928 [Multi-domain]  Cd Length: 137  Bit Score: 77.06  E-value: 2.86e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468687271 113 LFVCSLDMLSSAFQlaggKVAGDIFKD--NAILSNPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLEVSSAIPIIMG 190
Cdd:pfam02690   1 LFLFGMKLMSDGLQ----KLAGGRLRRilEKLTSNPLKGFLVGLLVTALLQSSSATTVMVVGFVNAGLLTLAQAIGVIMG 76
                          90
                  ....*....|....
gi 2468687271 191 SNIGTSVTNTIVAL 204
Cdd:pfam02690  77 ANIGTTVTAQLIAF 90
NptA COG1283
Na+/phosphate symporter [Inorganic ion transport and metabolism];
106-238 3.16e-14

Na+/phosphate symporter [Inorganic ion transport and metabolism];


Pssm-ID: 224202 [Multi-domain]  Cd Length: 533  Bit Score: 73.44  E-value: 3.16e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468687271 106 LMLTFLYLFVCSLDMLSSAFQLAGGKVAGDIFkdNAILSNPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLEVSSAI 185
Cdd:COG1283     9 NLLGAVALLLFGIKMVGDGVQRAAGDRLRKIL--ARFTSNPILGVLAGIVATALLQSSTATTVLTIGFVAAGLLSLKQAI 86
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 2468687271 186 PIIMGSNIGTSVTNTIVALmqaGDRTDFRRAFAGATVHDCFNWLSVLVLLPLE 238
Cdd:COG1283    87 GVILGANIGTTVTAWIVAL---DLSWLSPPLLAIGAILFFFGKSSKLRQLGRV 136
Na_Pi_symport NF037997
Na/Pi symporter; Proteins of this family belong to the Phosphate:Na+ Symporter (PNaS) ...
110-204 6.38e-08

Na/Pi symporter; Proteins of this family belong to the Phosphate:Na+ Symporter (PNaS) superfamily.


Pssm-ID: 411591 [Multi-domain]  Cd Length: 294  Bit Score: 52.99  E-value: 6.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468687271 110 FLYLFVCSLDMLSSA-FQLAGGKVAGDIFKdnaILSNPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLEVSSAIPII 188
Cdd:NF037997    4 YIAIFLLGMTVLRSGlFNLSGHKLKTWLLK---FTDTPLKGFLTGTVITAILQSSSAVMVLTVGLVSAGILTFRQSIGII 80
                          90
                  ....*....|....*.
gi 2468687271 189 MGSNIGTSVTNTIVAL 204
Cdd:NF037997   81 LGTNIGTTFTTEFITF 96
NptA COG1283
Na+/phosphate symporter [Inorganic ion transport and metabolism];
87-286 1.70e-07

Na+/phosphate symporter [Inorganic ion transport and metabolism];


Pssm-ID: 224202 [Multi-domain]  Cd Length: 533  Bit Score: 52.64  E-value: 1.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468687271  87 ESRLVPKLCQAGAMLL---------KVPLMLTFLYLFVCSLDMLSSAFQ-LAGGKVAGDIFKdnAILSNPVAGLVVGILV 156
Cdd:COG1283   107 LSWLSPPLLAIGAILFffgkssklrQLGRVLFGIGLIFLSLELLGQATEpLRQSPAFSDFIA--KLSDDPIVALLIGALL 184
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468687271 157 TVLVQSSSTSTSIIVSMVSSGLLEVSSAIPIIMGSNIGTSVTNTIVALmqAGDRTDFRRAFAgatvHDCFNWLSVLVLLP 236
Cdd:COG1283   185 TALIQSSLAAIGILLSLTSQGLISLEAALALVLGANLGTTITAVLAAL--GASAAARRVALG----NLLFNLIGVLIFLP 258
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2468687271 237 LeaaTGYLHHIT---------RLVVAS--FNIhggrdapdLLKIITEPFTKLIIQLDESVI 286
Cdd:COG1283   259 V---IHLLATFAsklslppaaLIAHAHllFNI--------VLALAALPFTGLLARFVTRLI 308
Na_Pi_symport NF037997
Na/Pi symporter; Proteins of this family belong to the Phosphate:Na+ Symporter (PNaS) ...
145-237 6.68e-06

Na/Pi symporter; Proteins of this family belong to the Phosphate:Na+ Symporter (PNaS) superfamily.


Pssm-ID: 411591 [Multi-domain]  Cd Length: 294  Bit Score: 46.82  E-value: 6.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468687271 145 NPVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLEVSSAIPIIMGSNIGTSVTNTIVALmqAGDRTDFRRAFAgatvHD 224
Cdd:NF037997  163 SLLLALLIGTVLTAIIQSSSATTGITMSFLNEGILTLPAGIAIMLGANIGTCITALLASI--GSGKEAKLTAYA----HI 236
                          90
                  ....*....|...
gi 2468687271 225 CFNWLSVLVLLPL 237
Cdd:NF037997  237 WLNVLGVLLFLPF 249
2a58 TIGR01013
Phosphate:Na+ Symporter (PNaS) Family; [Transport and binding proteins, Cations and iron ...
106-251 1.37e-05

Phosphate:Na+ Symporter (PNaS) Family; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 162157 [Multi-domain]  Cd Length: 456  Bit Score: 46.39  E-value: 1.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2468687271 106 LMLTFLYLFVCSLDMLSSAFQLAGGKVAGDIFK----DNAILSNPVAG---LVVGILVTVLVQSSSTSTSIIVSMVSSGL 178
Cdd:TIGR01013 223 LALPFVRLCARLILVVIPLNSLLDGQVAPVILDvinlDTPVPFLWVTGyeaLLVGDAMTFIIQSSSVFTSALTPLVGKGV 302
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2468687271 179 LEVSSAIPIIMGSNIGTSVTNTIVALmqAGDRTDFRRAFAGATVHDCFNWLSVLVLLPLEAATGYLHHITRLV 251
Cdd:TIGR01013 303 ISLERAYPLVLGSNIGTTLTAVLAAL--LSEDEKRRSALQIAYCHNLFNISGIVLFYPLPCTRKPIAAARGFG 373
NaPi_cotrn_rel TIGR00704
Na/Pi-cotransporter; This model describes essentially the full length of an uncharacterized ...
146-204 8.56e-03

Na/Pi-cotransporter; This model describes essentially the full length of an uncharacterized protein from Bacillus subtilis and correponding lengths of longer proteins from E. coli and Treponema pallidum. PSI-BLAST analysis converges to demonstrate homology to one other group of proteins, type II sodium/phosphate (Na/Pi) cotransporters. A well-conserved repeated domain in this family, approximately 60 residues in length, is also repeated in the Na/Pi cotransporters, although with greater spacing between the repeats. The two families share additional homology in the region after the first repeat, share the properly of having extensive hydrophobic regions, and may be similar in function. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273225 [Multi-domain]  Cd Length: 308  Bit Score: 37.59  E-value: 8.56e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 2468687271 146 PVAGLVVGILVTVLVQSSSTSTSIIVSMVSSGLLEVSSAIPIIMGSNIGTSVTNTIVAL 204
Cdd:TIGR00704  44 KLKAFCAGIGFTAILQSSNAFMMIVIGFVAADLLAFAPAIPIILGADVGSAFMAEFIAF 102
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH