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Conserved domains on  [gi|1370453688|ref|XP_024303830|]
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rho guanine nucleotide exchange factor 10-like protein isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
WD40_2 pfam19056
WD40 repeated domain; This entry contains an array of WD40 repeats found in RhoGEF proteins.
754-1244 0e+00

WD40 repeated domain; This entry contains an array of WD40 repeats found in RhoGEF proteins.


:

Pssm-ID: 436927  Cd Length: 489  Bit Score: 755.70  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688  754 AFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPLAAPVLCMEYIP 833
Cdd:pfam19056    1 VFMSKQQEFKLECAVHNPEPSALLGFSADSTSLPQGYLWVGSCGTSQMGQIEIFSLNRSSPRVVESFNVESRVLCMEYVP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688  834 ELEEEAESrdESPTVADPSATVH-PTICLGLQDGSILLYSSVDTGTQCLVSC-RSPGLQPVLCLRHSPFHLLAGLQDGTL 911
Cdd:pfam19056   81 EEPEPEEE--EAVRAEREAKKPGvPTICLGLEDGSISVYGSVQTAKKCLLQHfFTPERSPVLCLKHSPQFLFAGLVNGKV 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688  912 AAYPRTSGGvLWDLESPPVClTVGPGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVSVTHMVKAGSGV 991
Cdd:pfam19056  159 AVYARAEDG-LWDPEPPKVV-KLGVLPVRSLLALEDTVWASCGNQVTVISGETLQTEQSFEAHQDEGMSVSHMVVAGVGV 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688  992 WMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGM 1071
Cdd:pfam19056  237 WMAFSSGSSIRLFHTETLEHLQDINIATPVHFMLPGQKRVSVTSLLVCQGLLWVGTNLGVIVALPVPRLEGIPKITGRGM 316
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688 1072 VSLNGHCGPVAFLAVATSILaPDILRSDQEEAE--GPRAEEDKPDGQAHEPMPD-SHVGRELTRKKGILLQYRLRSTAHL 1148
Cdd:pfam19056  317 VSLHAHCGPVKFLVAASSTL-PDLLKRDKEKEEssSASGSEPKPDGEQKESLPGlEASAPSPSRKKGVLLQYRLRSTSQL 395
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688 1149 PGPLLSMREPAPADG-AALEHSEEDGSIYEMADDPDIWVRSRPCARDAHRKEICSVAIISGGQGYRNFGSalgSSGRQAP 1227
Cdd:pfam19056  396 PGDLLSSSGSLTLDSsGSLEHSPEDGSIYELLDDPDVWVRGRPCARDARRADVSSVAVISGGQGHRRLGR---KSKGQQR 472
                          490
                   ....*....|....*..
gi 1370453688 1228 CGETDSTLLIWQVPLML 1244
Cdd:pfam19056  473 PEELESTLMVWQIPLTV 489
PH_19 pfam19057
PH domain; This entry contains a PH domain found in RhoGEF proteins.
491-646 2.54e-62

PH domain; This entry contains a PH domain found in RhoGEF proteins.


:

Pssm-ID: 436928  Cd Length: 154  Bit Score: 209.26  E-value: 2.54e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688  491 LNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQleiSSLVPLGPKYVVKWNTAL 570
Cdd:pfam19057    2 LNKLLSSGQRYLIRQDDVVETVYNERGEVIKTKERRLFLLNDLLVCVTVNSKSGSSFGS---SSLVPTGEKYKLKWSVPL 78
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370453688  571 PQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQ 646
Cdd:pfam19057   79 SDVEVVESGQSPNTSRASSLNAGGSAKRLKSVVNAKPNKVDLGPPHLYQELQDLLHDLEVVGQISKLVGTLKGTYQ 154
RhoGEF cd00160
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous ...
282-466 3.49e-45

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.


:

Pssm-ID: 238091 [Multi-domain]  Cd Length: 181  Bit Score: 160.93  E-value: 3.49e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688  282 RRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEpKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWD-STEKIGD 360
Cdd:cd00160      1 RQEVIKELLQTERNYVRDLKLLVEVFLKPLDKEL-LPLSPEEVELLFGNIEEIYEFHRIFLKSLEERVEEWDkSGPRIGD 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688  361 LFVASFSKsmvLDVYSDYVNNFTSAMSIIKKACLTKPAFLEFLKRRQvCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKN 440
Cdd:cd00160     80 VFLKLAPF---FKIYSEYCSNHPDALELLKKLKKFNKFFQEFLEKAE-SECGRLKLESLLLKPVQRLTKYPLLLKELLKH 155
                          170       180
                   ....*....|....*....|....*.
gi 1370453688  441 TPRGHPDRLSLQLALTELETLAEKLN 466
Cdd:cd00160    156 TPDGHEDREDLKKALEAIKEVASQVN 181
 
Name Accession Description Interval E-value
WD40_2 pfam19056
WD40 repeated domain; This entry contains an array of WD40 repeats found in RhoGEF proteins.
754-1244 0e+00

WD40 repeated domain; This entry contains an array of WD40 repeats found in RhoGEF proteins.


Pssm-ID: 436927  Cd Length: 489  Bit Score: 755.70  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688  754 AFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPLAAPVLCMEYIP 833
Cdd:pfam19056    1 VFMSKQQEFKLECAVHNPEPSALLGFSADSTSLPQGYLWVGSCGTSQMGQIEIFSLNRSSPRVVESFNVESRVLCMEYVP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688  834 ELEEEAESrdESPTVADPSATVH-PTICLGLQDGSILLYSSVDTGTQCLVSC-RSPGLQPVLCLRHSPFHLLAGLQDGTL 911
Cdd:pfam19056   81 EEPEPEEE--EAVRAEREAKKPGvPTICLGLEDGSISVYGSVQTAKKCLLQHfFTPERSPVLCLKHSPQFLFAGLVNGKV 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688  912 AAYPRTSGGvLWDLESPPVClTVGPGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVSVTHMVKAGSGV 991
Cdd:pfam19056  159 AVYARAEDG-LWDPEPPKVV-KLGVLPVRSLLALEDTVWASCGNQVTVISGETLQTEQSFEAHQDEGMSVSHMVVAGVGV 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688  992 WMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGM 1071
Cdd:pfam19056  237 WMAFSSGSSIRLFHTETLEHLQDINIATPVHFMLPGQKRVSVTSLLVCQGLLWVGTNLGVIVALPVPRLEGIPKITGRGM 316
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688 1072 VSLNGHCGPVAFLAVATSILaPDILRSDQEEAE--GPRAEEDKPDGQAHEPMPD-SHVGRELTRKKGILLQYRLRSTAHL 1148
Cdd:pfam19056  317 VSLHAHCGPVKFLVAASSTL-PDLLKRDKEKEEssSASGSEPKPDGEQKESLPGlEASAPSPSRKKGVLLQYRLRSTSQL 395
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688 1149 PGPLLSMREPAPADG-AALEHSEEDGSIYEMADDPDIWVRSRPCARDAHRKEICSVAIISGGQGYRNFGSalgSSGRQAP 1227
Cdd:pfam19056  396 PGDLLSSSGSLTLDSsGSLEHSPEDGSIYELLDDPDVWVRGRPCARDARRADVSSVAVISGGQGHRRLGR---KSKGQQR 472
                          490
                   ....*....|....*..
gi 1370453688 1228 CGETDSTLLIWQVPLML 1244
Cdd:pfam19056  473 PEELESTLMVWQIPLTV 489
PH_19 pfam19057
PH domain; This entry contains a PH domain found in RhoGEF proteins.
491-646 2.54e-62

PH domain; This entry contains a PH domain found in RhoGEF proteins.


Pssm-ID: 436928  Cd Length: 154  Bit Score: 209.26  E-value: 2.54e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688  491 LNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQleiSSLVPLGPKYVVKWNTAL 570
Cdd:pfam19057    2 LNKLLSSGQRYLIRQDDVVETVYNERGEVIKTKERRLFLLNDLLVCVTVNSKSGSSFGS---SSLVPTGEKYKLKWSVPL 78
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370453688  571 PQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQ 646
Cdd:pfam19057   79 SDVEVVESGQSPNTSRASSLNAGGSAKRLKSVVNAKPNKVDLGPPHLYQELQDLLHDLEVVGQISKLVGTLKGTYQ 154
RhoGEF cd00160
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous ...
282-466 3.49e-45

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.


Pssm-ID: 238091 [Multi-domain]  Cd Length: 181  Bit Score: 160.93  E-value: 3.49e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688  282 RRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEpKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWD-STEKIGD 360
Cdd:cd00160      1 RQEVIKELLQTERNYVRDLKLLVEVFLKPLDKEL-LPLSPEEVELLFGNIEEIYEFHRIFLKSLEERVEEWDkSGPRIGD 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688  361 LFVASFSKsmvLDVYSDYVNNFTSAMSIIKKACLTKPAFLEFLKRRQvCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKN 440
Cdd:cd00160     80 VFLKLAPF---FKIYSEYCSNHPDALELLKKLKKFNKFFQEFLEKAE-SECGRLKLESLLLKPVQRLTKYPLLLKELLKH 155
                          170       180
                   ....*....|....*....|....*.
gi 1370453688  441 TPRGHPDRLSLQLALTELETLAEKLN 466
Cdd:cd00160    156 TPDGHEDREDLKKALEAIKEVASQVN 181
RhoGEF smart00325
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Guanine nucleotide exchange ...
285-467 1.56e-44

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains. Improved coverage.


Pssm-ID: 214619 [Multi-domain]  Cd Length: 180  Bit Score: 159.00  E-value: 1.56e-44
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688   285 ILGSIVQSEGSYVESLKRILQDYRNPLMEMEpKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWD-STEKIGDLFV 363
Cdd:smart00325    1 VLKELLQTERNYVRDLKLLVEVFLKPLKKEL-KLLSPNELETLFGNIEEIYEFHRDFLDELEERIEEWDdSVERIGDVFL 79
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688   364 ASfskSMVLDVYSDYVNNFTSAMSIIKKaCLTKPAFLEFLKRRQVCSP-DRVTLYGLMVKPIQRFPQFILLLQDMLKNTP 442
Cdd:smart00325   80 KL---EEFFKIYSEYCSNHPDALELLKK-LKKNPRFQKFLKEIESSPQcRRLTLESLLLKPVQRLTKYPLLLKELLKHTP 155
                           170       180
                    ....*....|....*....|....*
gi 1370453688   443 RGHPDRLSLQLALTELETLAEKLNE 467
Cdd:smart00325  156 EDHEDREDLKKALKAIKELANQVNE 180
RhoGEF pfam00621
RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called ...
289-466 1.30e-43

RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.


Pssm-ID: 425783 [Multi-domain]  Cd Length: 176  Bit Score: 156.30  E-value: 1.30e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688  289 IVQSEGSYVESLKRILQDYRNPlmEMEPKALSARKCQVVFFRVKEILHCHSMFqiALSSRVAEWDSTEKIGDLFVASFSK 368
Cdd:pfam00621    5 LLQTERSYVRDLEILVEVFLPP--NSKPLSESEEEIKTIFSNIEEIYELHRQL--LLEELLKEWISIQRIGDIFLKFAPG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688  369 smvLDVYSDYVNNFTSAMSIIKKACLTKPAFLEFLKRRQVCSP-DRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPD 447
Cdd:pfam00621   81 ---FKVYSTYCSNYPKALELLKKLLKKNPKFRAFLEELEANPEcRGLDLNSFLIKPVQRIPRYPLLLKELLKHTPPDHPD 157
                          170
                   ....*....|....*....
gi 1370453688  448 RLSLQLALTELETLAEKLN 466
Cdd:pfam00621  158 YEDLKKALEAIKEVAKQIN 176
ROM1 COG5422
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ...
273-466 2.52e-05

RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms];


Pssm-ID: 227709 [Multi-domain]  Cd Length: 1175  Bit Score: 48.73  E-value: 2.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688  273 EGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARK--CQVVFFRVKEILHCHSMFQIALSSRVA 350
Cdd:COG5422    476 ESLPKQEIKRQEAIYEVIYTERDFVKDLEYLRDTWIKPLEESNIIPENARRnfIKHVFANINEIYAVNSKLLKALTNRQC 555
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688  351 EWDSTEKIGDLFVASFSKsmvLDVYSDYVNNFTSAMSIIKKACLTKPAFLEFLKRRQVC-SPDRVTLYGLMVKPIQRFPQ 429
Cdd:COG5422    556 LSPIVNGIADIFLDYVPK---FEPFIKYGASQPYAKYEFEREKSVNPNFARFDHEVERLdESRKLELDGYLTKPTTRLAR 632
                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1370453688  430 FILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLN 466
Cdd:COG5422    633 YPLLLEEVLKFTDPDNPDTEDIPKVIDMLREFLSRLN 669
 
Name Accession Description Interval E-value
WD40_2 pfam19056
WD40 repeated domain; This entry contains an array of WD40 repeats found in RhoGEF proteins.
754-1244 0e+00

WD40 repeated domain; This entry contains an array of WD40 repeats found in RhoGEF proteins.


Pssm-ID: 436927  Cd Length: 489  Bit Score: 755.70  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688  754 AFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPLAAPVLCMEYIP 833
Cdd:pfam19056    1 VFMSKQQEFKLECAVHNPEPSALLGFSADSTSLPQGYLWVGSCGTSQMGQIEIFSLNRSSPRVVESFNVESRVLCMEYVP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688  834 ELEEEAESrdESPTVADPSATVH-PTICLGLQDGSILLYSSVDTGTQCLVSC-RSPGLQPVLCLRHSPFHLLAGLQDGTL 911
Cdd:pfam19056   81 EEPEPEEE--EAVRAEREAKKPGvPTICLGLEDGSISVYGSVQTAKKCLLQHfFTPERSPVLCLKHSPQFLFAGLVNGKV 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688  912 AAYPRTSGGvLWDLESPPVClTVGPGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVSVTHMVKAGSGV 991
Cdd:pfam19056  159 AVYARAEDG-LWDPEPPKVV-KLGVLPVRSLLALEDTVWASCGNQVTVISGETLQTEQSFEAHQDEGMSVSHMVVAGVGV 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688  992 WMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGM 1071
Cdd:pfam19056  237 WMAFSSGSSIRLFHTETLEHLQDINIATPVHFMLPGQKRVSVTSLLVCQGLLWVGTNLGVIVALPVPRLEGIPKITGRGM 316
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688 1072 VSLNGHCGPVAFLAVATSILaPDILRSDQEEAE--GPRAEEDKPDGQAHEPMPD-SHVGRELTRKKGILLQYRLRSTAHL 1148
Cdd:pfam19056  317 VSLHAHCGPVKFLVAASSTL-PDLLKRDKEKEEssSASGSEPKPDGEQKESLPGlEASAPSPSRKKGVLLQYRLRSTSQL 395
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688 1149 PGPLLSMREPAPADG-AALEHSEEDGSIYEMADDPDIWVRSRPCARDAHRKEICSVAIISGGQGYRNFGSalgSSGRQAP 1227
Cdd:pfam19056  396 PGDLLSSSGSLTLDSsGSLEHSPEDGSIYELLDDPDVWVRGRPCARDARRADVSSVAVISGGQGHRRLGR---KSKGQQR 472
                          490
                   ....*....|....*..
gi 1370453688 1228 CGETDSTLLIWQVPLML 1244
Cdd:pfam19056  473 PEELESTLMVWQIPLTV 489
PH_19 pfam19057
PH domain; This entry contains a PH domain found in RhoGEF proteins.
491-646 2.54e-62

PH domain; This entry contains a PH domain found in RhoGEF proteins.


Pssm-ID: 436928  Cd Length: 154  Bit Score: 209.26  E-value: 2.54e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688  491 LNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQleiSSLVPLGPKYVVKWNTAL 570
Cdd:pfam19057    2 LNKLLSSGQRYLIRQDDVVETVYNERGEVIKTKERRLFLLNDLLVCVTVNSKSGSSFGS---SSLVPTGEKYKLKWSVPL 78
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370453688  571 PQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQ 646
Cdd:pfam19057   79 SDVEVVESGQSPNTSRASSLNAGGSAKRLKSVVNAKPNKVDLGPPHLYQELQDLLHDLEVVGQISKLVGTLKGTYQ 154
RhoGEF cd00160
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous ...
282-466 3.49e-45

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.


Pssm-ID: 238091 [Multi-domain]  Cd Length: 181  Bit Score: 160.93  E-value: 3.49e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688  282 RRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEpKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWD-STEKIGD 360
Cdd:cd00160      1 RQEVIKELLQTERNYVRDLKLLVEVFLKPLDKEL-LPLSPEEVELLFGNIEEIYEFHRIFLKSLEERVEEWDkSGPRIGD 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688  361 LFVASFSKsmvLDVYSDYVNNFTSAMSIIKKACLTKPAFLEFLKRRQvCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKN 440
Cdd:cd00160     80 VFLKLAPF---FKIYSEYCSNHPDALELLKKLKKFNKFFQEFLEKAE-SECGRLKLESLLLKPVQRLTKYPLLLKELLKH 155
                          170       180
                   ....*....|....*....|....*.
gi 1370453688  441 TPRGHPDRLSLQLALTELETLAEKLN 466
Cdd:cd00160    156 TPDGHEDREDLKKALEAIKEVASQVN 181
RhoGEF smart00325
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Guanine nucleotide exchange ...
285-467 1.56e-44

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains. Improved coverage.


Pssm-ID: 214619 [Multi-domain]  Cd Length: 180  Bit Score: 159.00  E-value: 1.56e-44
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688   285 ILGSIVQSEGSYVESLKRILQDYRNPLMEMEpKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWD-STEKIGDLFV 363
Cdd:smart00325    1 VLKELLQTERNYVRDLKLLVEVFLKPLKKEL-KLLSPNELETLFGNIEEIYEFHRDFLDELEERIEEWDdSVERIGDVFL 79
                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688   364 ASfskSMVLDVYSDYVNNFTSAMSIIKKaCLTKPAFLEFLKRRQVCSP-DRVTLYGLMVKPIQRFPQFILLLQDMLKNTP 442
Cdd:smart00325   80 KL---EEFFKIYSEYCSNHPDALELLKK-LKKNPRFQKFLKEIESSPQcRRLTLESLLLKPVQRLTKYPLLLKELLKHTP 155
                           170       180
                    ....*....|....*....|....*
gi 1370453688   443 RGHPDRLSLQLALTELETLAEKLNE 467
Cdd:smart00325  156 EDHEDREDLKKALKAIKELANQVNE 180
RhoGEF pfam00621
RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called ...
289-466 1.30e-43

RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.


Pssm-ID: 425783 [Multi-domain]  Cd Length: 176  Bit Score: 156.30  E-value: 1.30e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688  289 IVQSEGSYVESLKRILQDYRNPlmEMEPKALSARKCQVVFFRVKEILHCHSMFqiALSSRVAEWDSTEKIGDLFVASFSK 368
Cdd:pfam00621    5 LLQTERSYVRDLEILVEVFLPP--NSKPLSESEEEIKTIFSNIEEIYELHRQL--LLEELLKEWISIQRIGDIFLKFAPG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688  369 smvLDVYSDYVNNFTSAMSIIKKACLTKPAFLEFLKRRQVCSP-DRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPD 447
Cdd:pfam00621   81 ---FKVYSTYCSNYPKALELLKKLLKKNPKFRAFLEELEANPEcRGLDLNSFLIKPVQRIPRYPLLLKELLKHTPPDHPD 157
                          170
                   ....*....|....*....
gi 1370453688  448 RLSLQLALTELETLAEKLN 466
Cdd:pfam00621  158 YEDLKKALEAIKEVAKQIN 176
ROM1 COG5422
RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction ...
273-466 2.52e-05

RhoGEF, Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases [Signal transduction mechanisms];


Pssm-ID: 227709 [Multi-domain]  Cd Length: 1175  Bit Score: 48.73  E-value: 2.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688  273 EGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARK--CQVVFFRVKEILHCHSMFQIALSSRVA 350
Cdd:COG5422    476 ESLPKQEIKRQEAIYEVIYTERDFVKDLEYLRDTWIKPLEESNIIPENARRnfIKHVFANINEIYAVNSKLLKALTNRQC 555
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370453688  351 EWDSTEKIGDLFVASFSKsmvLDVYSDYVNNFTSAMSIIKKACLTKPAFLEFLKRRQVC-SPDRVTLYGLMVKPIQRFPQ 429
Cdd:COG5422    556 LSPIVNGIADIFLDYVPK---FEPFIKYGASQPYAKYEFEREKSVNPNFARFDHEVERLdESRKLELDGYLTKPTTRLAR 632
                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1370453688  430 FILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLN 466
Cdd:COG5422    633 YPLLLEEVLKFTDPDNPDTEDIPKVIDMLREFLSRLN 669
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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