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Conserved domains on  [gi|1370458794|ref|XP_024304123|]
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sestrin-3 isoform X2 [Homo sapiens]

Protein Classification

sestrin( domain architecture ID 10519211)

sestrin functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PA26 pfam04636
PA26 p53-induced protein (sestrin); PA26 is a p53-inducible protein. Its function is unknown. ...
1-412 0e+00

PA26 p53-induced protein (sestrin); PA26 is a p53-inducible protein. Its function is unknown. It has similarity to pfam04636 in its N-terminus.


:

Pssm-ID: 461375  Cd Length: 442  Bit Score: 763.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370458794   1 MSLHTQYLESFLRSQFYMLRMDGPLPLPYRHYIAIMAAARHQCSYLINMHVDEFLKTGGIAEWLNGLEYVPQRLKNLNEI 80
Cdd:pfam04636  42 MGLHPQYLESFLRTQHYLLRMDGPLPLHYRHYIAIMAAARHQCSYLVSLHESEFLQVGGDPEWLKGLDHAPQKLRNLDEL 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370458794  81 NKLLAHRPWLITKEHIQKLVKTGENNWSLPELVHAVVLLAHYHALASFVFGSGINPERDPEISNGFRLISVNNFCVCDla 160
Cdd:pfam04636 122 NKLLAHRPWLITKEHIEALLKGGEDSWSLAELVHAVVLLAHFHSLASFVFGCGINPEVDLEGGHTFQPPSPTSPCNIG-- 199
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370458794 161 NDNNIENASLSGSNFGIVDSLSELEALMERMKRLQEEREDEEASQEEMSTRFEKEKKESLFVVSGDTFHSFPhsdfeddm 240
Cdd:pfam04636 200 NGNSSPPSDLELGRSAASDSEIEVEALMERMKKLQEEQDEEEASQEEMSTRFEKEESESLLVPSSSILESAP-------- 271
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370458794 241 iiTSDVSRYIEDPGFGYEDFARRGEEHLPTFRAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMVYNLTYNTMATHEDVDT 320
Cdd:pfam04636 272 --PSDISRYVEDPDFGYQDFARRGEQDIPTFRAQDYSWEDHGFSLVNRLYPDIGQLLDEKFRVAYNLTYNTMAMHKGVDT 349
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370458794 321 TMLRRALFNYVHCMFGIRYDDYDYGEVNQLLERSLKVYIKTVTCYPERTTKRMYDSYWRQFKHSEKVHVNLLLMEARMQA 400
Cdd:pfam04636 350 SMLRRAIWNYIHCVYGIRYDDYDYGEVNQLLERSLKVYIKTVACYPEKTTTRDYDSFWRQFKHSEKVHVNLLLMEARMQA 429
                         410
                  ....*....|..
gi 1370458794 401 ELLYALRAITRH 412
Cdd:pfam04636 430 ELLYALRAITRY 441
 
Name Accession Description Interval E-value
PA26 pfam04636
PA26 p53-induced protein (sestrin); PA26 is a p53-inducible protein. Its function is unknown. ...
1-412 0e+00

PA26 p53-induced protein (sestrin); PA26 is a p53-inducible protein. Its function is unknown. It has similarity to pfam04636 in its N-terminus.


Pssm-ID: 461375  Cd Length: 442  Bit Score: 763.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370458794   1 MSLHTQYLESFLRSQFYMLRMDGPLPLPYRHYIAIMAAARHQCSYLINMHVDEFLKTGGIAEWLNGLEYVPQRLKNLNEI 80
Cdd:pfam04636  42 MGLHPQYLESFLRTQHYLLRMDGPLPLHYRHYIAIMAAARHQCSYLVSLHESEFLQVGGDPEWLKGLDHAPQKLRNLDEL 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370458794  81 NKLLAHRPWLITKEHIQKLVKTGENNWSLPELVHAVVLLAHYHALASFVFGSGINPERDPEISNGFRLISVNNFCVCDla 160
Cdd:pfam04636 122 NKLLAHRPWLITKEHIEALLKGGEDSWSLAELVHAVVLLAHFHSLASFVFGCGINPEVDLEGGHTFQPPSPTSPCNIG-- 199
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370458794 161 NDNNIENASLSGSNFGIVDSLSELEALMERMKRLQEEREDEEASQEEMSTRFEKEKKESLFVVSGDTFHSFPhsdfeddm 240
Cdd:pfam04636 200 NGNSSPPSDLELGRSAASDSEIEVEALMERMKKLQEEQDEEEASQEEMSTRFEKEESESLLVPSSSILESAP-------- 271
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370458794 241 iiTSDVSRYIEDPGFGYEDFARRGEEHLPTFRAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMVYNLTYNTMATHEDVDT 320
Cdd:pfam04636 272 --PSDISRYVEDPDFGYQDFARRGEQDIPTFRAQDYSWEDHGFSLVNRLYPDIGQLLDEKFRVAYNLTYNTMAMHKGVDT 349
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370458794 321 TMLRRALFNYVHCMFGIRYDDYDYGEVNQLLERSLKVYIKTVTCYPERTTKRMYDSYWRQFKHSEKVHVNLLLMEARMQA 400
Cdd:pfam04636 350 SMLRRAIWNYIHCVYGIRYDDYDYGEVNQLLERSLKVYIKTVACYPEKTTTRDYDSFWRQFKHSEKVHVNLLLMEARMQA 429
                         410
                  ....*....|..
gi 1370458794 401 ELLYALRAITRH 412
Cdd:pfam04636 430 ELLYALRAITRY 441
 
Name Accession Description Interval E-value
PA26 pfam04636
PA26 p53-induced protein (sestrin); PA26 is a p53-inducible protein. Its function is unknown. ...
1-412 0e+00

PA26 p53-induced protein (sestrin); PA26 is a p53-inducible protein. Its function is unknown. It has similarity to pfam04636 in its N-terminus.


Pssm-ID: 461375  Cd Length: 442  Bit Score: 763.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370458794   1 MSLHTQYLESFLRSQFYMLRMDGPLPLPYRHYIAIMAAARHQCSYLINMHVDEFLKTGGIAEWLNGLEYVPQRLKNLNEI 80
Cdd:pfam04636  42 MGLHPQYLESFLRTQHYLLRMDGPLPLHYRHYIAIMAAARHQCSYLVSLHESEFLQVGGDPEWLKGLDHAPQKLRNLDEL 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370458794  81 NKLLAHRPWLITKEHIQKLVKTGENNWSLPELVHAVVLLAHYHALASFVFGSGINPERDPEISNGFRLISVNNFCVCDla 160
Cdd:pfam04636 122 NKLLAHRPWLITKEHIEALLKGGEDSWSLAELVHAVVLLAHFHSLASFVFGCGINPEVDLEGGHTFQPPSPTSPCNIG-- 199
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370458794 161 NDNNIENASLSGSNFGIVDSLSELEALMERMKRLQEEREDEEASQEEMSTRFEKEKKESLFVVSGDTFHSFPhsdfeddm 240
Cdd:pfam04636 200 NGNSSPPSDLELGRSAASDSEIEVEALMERMKKLQEEQDEEEASQEEMSTRFEKEESESLLVPSSSILESAP-------- 271
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370458794 241 iiTSDVSRYIEDPGFGYEDFARRGEEHLPTFRAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMVYNLTYNTMATHEDVDT 320
Cdd:pfam04636 272 --PSDISRYVEDPDFGYQDFARRGEQDIPTFRAQDYSWEDHGFSLVNRLYPDIGQLLDEKFRVAYNLTYNTMAMHKGVDT 349
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370458794 321 TMLRRALFNYVHCMFGIRYDDYDYGEVNQLLERSLKVYIKTVTCYPERTTKRMYDSYWRQFKHSEKVHVNLLLMEARMQA 400
Cdd:pfam04636 350 SMLRRAIWNYIHCVYGIRYDDYDYGEVNQLLERSLKVYIKTVACYPEKTTTRDYDSFWRQFKHSEKVHVNLLLMEARMQA 429
                         410
                  ....*....|..
gi 1370458794 401 ELLYALRAITRH 412
Cdd:pfam04636 430 ELLYALRAITRY 441
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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